| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0007140 | BP | male meiosis | A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. |
TEX14, TDRD9, KIF18A, TEX15, AGO4, CYP26B1, MLH3 |
GO:0007141 | BP | male meiosis I | A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. |
MEIOC, RAD51C, BRCA2, CCNA1, TRIP13 |
GO:0007143 | BP | female meiotic division | A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. |
EREG, PRKAR1A, PPP2R1A, HSF1, KIAA0430 |
GO:0007144 | BP | female meiosis I | The cell cycle process in which the first meiotic division occurs in the female germline. |
MEIOC, CDC25B, TRIP13, MLH3 |
GO:0007147 | BP | female meiosis II | The cell cycle process in which the second meiotic division occurs in the female germline. |
MASTL |
GO:0007154 | BP | cell communication | Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. |
OIP5, ANG, NRG1, TRIP10, FRAS1, KREMEN1, ENPP5 |
GO:0007155 | BP | cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
SSPO, CHL1, CYR61, ISLR, NCAN, TOR1A, CASK, PDZD2, ADAM12, TGFB1I1, MTSS1, EDIL3, NUAK1, NRP2, PLXNC1, SORBS3, LPXN, CTNND1, ADAM23, WISP2, SORBS2, FARP2, CLSTN1, WISP1, BMP10, FN1, AMBP, BGLAP, VTN, VWF, ATP1B1, APP, ITGB3, ITGB2, ICAM1, ITGAV, LAMB1, THBS1, ITGA5, RPSA, SPP1, PTPRF, HAPLN1, LAMC1, ITGAM, COL6A1, COL6A2, COL6A3, GP1BB, CCL4, CCL2, NCAM1, VCAN, SELL, CD99, B4GALT1, ITGB4, PECAM1, ATP2A2, CD36, PRKCA, ITGA2, CDH2, CD58, VCAM1, CD33, ITGAX, COL5A1, MAG, S1PR1, KITLG, CD9, TNXB, NME2, ANOS1, IL32, LAMA2, TNC, APC, FPR2, AZGP1, ITGB8, CTGF, EPHA3, CTNNA1, CTNNB1, ACTN2, SPAM1, ITGAE, COL15A1, COL18A1, ABL2, MCAM, CXCL12, CD151, CD97, COMP, BCAM, PRKX, EFNB2, EPHB4, EPHA4, EMP2, CDH6, CDH11, CDH15, RHOB, RAC1, SIRPA, OLR1, ADAM17, TNFAIP6, MYBPC1, COL4A3, APBA1, DSC2, DST, CD164, TYRO3, COL16A1, DDR1, MFGE8, CD47, TROAP, CNTN1, CDH17, ARHGAP5, MMRN1, PTK7, ITGB3BP, ADAM9, LSAMP, SEMA5A, ALCAM, ITGA9, COL4A6, NID2, DSG2, DGCR6, SCARF1, SELPLG, ADGRE1, GAS6, HES1, NEDD9, FAT1, SSPN, GPNMB, POSTN, NECTIN1, PTPRK, TGFBI, ZYX, IGFBP7, LAMA4, CYP1B1, LAMA3, AOC3, IGSF11, THEMIS2, RGMB, OLFM4, MAEA, AGGF1, CHST4, STAB2, CNTNAP5, TNR, SYMPK, LPP, BCAN, MAGI1, SIGLEC11, CSF3R, FEZ1, COL12A1, CIB1, OMD, FERMT1, SPON2, EMILIN2, PRKD2, TINAGL1, PCDHAC1, PNN, SPON1, TMEM8A, CASS4, STAB1, AATF, FLRT1, CNTN3, CTNNAL1, CFDP1, ITGA11, PCDHA7, PCDHA6, PCDHA4, GNE, SIGLEC7, SSX2IP, LOXL2, PCDHB3, PCDHA8, PCDHA5, PCDHA3, PCDHA2, PCDHA11, PCDHA10, PCDHA1, PCDHAC2, ADGRG1, LAMC3 |
GO:0007156 | BP | homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
PCDH17, PLXNB2, MPZL2, CLSTN1, ITGB1, PVR, CDH2, PTPRM, CDH5, CD200, PIK3CB, CDH6, CDH11, CDH12, CDH13, CDH15, PKD1, DSC2, PCDH1, SMAGP, CDH17, DSG2, FAT1, NECTIN1, SDK2, SDK1, PCDH19, FAT3, CADM1, CDHR2, PCDH11Y, PCDHAC1, CLSTN2, PCDH9, ROBO2, PCDH18, NECTIN3, CELSR3, TENM3, PCDH10, CDH22, PCDHGC3, PCDHA7, PCDHA6, PCDHA4, PCDHA12, IGSF9B, PCDHB9, PCDHB3, PCDHB14, PCDHA9, PCDHA8, PCDHA5, PCDHA3, PCDHA2, PCDHA13, PCDHA11, PCDHA10, PCDHA1, PCDHAC2 |
GO:0007157 | BP | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. |
ICAM1, ITGA5, PVR, SELE, CDH2, VCAM1, CBLN1, PTPRD, CD6, CD200, LGALS7, CXADR, CD164, SMAGP, ALCAM, NECTIN1, TENM4, NLGN1, CADM1, CD209, NECTIN3, TENM3 |
GO:0007158 | BP | neuron cell-cell adhesion | The attachment of a neuron to another cell via adhesion molecules. |
NCAM2, CNTN4, NLGN4X, NLGN1, TNR, NRXN1 |
GO:0007159 | BP | leukocyte cell-cell adhesion | The attachment of a leukocyte to another cell via adhesion molecules. |
ITGB2, ICAM1, ITGB1, ITGA5, CCL5, EZR, SELE, VCAM1, NT5E, CD40LG, SYK, CD209 |
GO:0007160 | BP | cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules. |
ITGB1BP1, BCL2L11, TECTA, ITGA10, ECM2, COL3A1, FGA, FGB, FGG, VTN, ITGB3, ITGB2, ITGB1, ITGAV, NID1, CD44, ITGB4, ITGA2, ITGB5, VCAM1, ITGA6, COL5A3, ITGA3, CTGF, CTNNB1, BCAM, EMP2, ADAMTS12, RAC1, PKD1, CDK5, TIAM1, ILK, ADAM9, NID2, ZYX, COL13A1, MUC4, SORBS1, JAM3, SIGLEC1, ITGA11, MKLN1, EPDR1, COL17A1, HPSE, TIMM10B, LYVE1 |
GO:0007161 | BP | calcium-independent cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction. |
FN1, ITGB1, PKD1 |
GO:0007162 | BP | negative regulation of cell adhesion | Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. |
ADAM10, PLXNB2, LPXN, DAB1, KNG1, RASA1, ERBB3, FBLN1, TNC, ARHGDIA, ARHGDIB, CDH13, JAM2, CD164, PDE3B, SEMA5A, ANGPT1, TGFBI, CBLL1 |
GO:0007163 | BP | establishment or maintenance of cell polarity | Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. |
SPINT2, CCL4, CTNNA1, CDC42, ACTR3, ACTR2, CRB1, DLG1, MAP7, FAT1, SFRP5, NPHP3, PARD3, SYNE2, PARD6B, PARVA, CDC42BPB |
GO:0007165 | BP | signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
ARHGAP42, GPR89A, AIP, APBB1, CLIC1, TNFRSF11B, PIK3CD, CHL1, CLDN4, IRS4, PTGES, MAP2K7, NRP1, TNFRSF10C, MGST3, RGS12, PPP1R12A, FYB, NPC1, ANGPT2, NPHP1, OGT, INPP4B, TLR3, CAPN5, CLDN3, RIPK2, AKAP10, TYROBP, PPP1R12B, SH3BP5, ADCY3, LY75, ADCY9, CREBL2, GREM1, TLR2, PDE8A, JAK2, LPXN, TRIM13, ZPR1, ZNF217, FLNB, ULK1, SKAP2, BCAR3, TNFSF13, RASSF9, PDE5A, WISP2, PDE9A, FGF18, PLEKHG5, NFAT5, FAM13A, IKBKAP, PDE8B, WISP1, CXCL14, CLIC3, GUCA1C, PEX11B, ACTL6A, EGFR, PLAU, C3, GNRH1, POMC, PENK, CGA, FSHB, LHB, GCG, IL1B, CD4, FGA, FGB, FGG, ESR1, OPN1SW, RAF1, ANXA1, NR3C1, CD74, ERBB2, GNAI2, IGF1, INHA, PRKCB, CCK, PGR, S100A9, S100A6, NPM1, CSF1R, HSP90AA1, LYN, IGF1R, MET, ANXA5, IGFBP1, NMB, FGF2, CXCL1, LGALS1, SPARC, ANXA4, PDGFRB, GPR89B, CXCL8, AR, NR2F1, TXN, KIT, IAPP, CHRNB1, RALA, RALB, BCR, VDR, IGF2R, CDK4, FCGR1A, CCL4, CCL2, HLA-DOB, JUP, RAC2, IFNGR1, HIVEP1, CREB1, PECAM1, IL7R, STMN1, GJA1, IGFBP2, ATF6, EPOR, CD53, FST, CD33, CHRM3, TRH, CAPN3, RASA1, FPR1, KITLG, C5AR1, MDK, FGF7, ERBB3, IGFBP4, NR4A1, EVI2A, MRC1, TNFSF4, ITPKA, IL4R, NR2F2, IGFBP6, IGFBP5, CXCR2, EDNRA, FAS, MAPK1, GRN, PTPRM, TNFRSF8, IMPA1, LTK, CASP1, EEF1D, GNA11, PDIA3, CCND3, CHRNA5, TSPO, ADORA1, SRI, NTS, GDI1, FGF9, SDC4, HIVEP2, GABRA5, AKT1, AKT2, SFN, S100A11, FCGR2B, STX2, LSP1, PHB, ADM, ADRA1A, IRS1, TIE1, ADRBK2, DEK, CHKA, CHRNA7, ACVR1B, TGFBR1, GNL1, LTBR, PPARG, COL15A1, STAT3, ELK3, ARHGAP25, PIK3CB, ABL2, IL12RB1, CXCL5, NR4A2, RANBP1, NAMPT, RANGAP1, IQGAP1, OR3A3, CXCL12, SOX9, NMU, CSNK1A1, CSNK1D, INPP1, CSNK1E, PGF, VEGFC, HINT1, GDI2, TNFSF10, BCAM, IRAK1, CLCN6, HDGF, MAP2K6, RCAN1, YARS, PRKAG1, PRKAA2, GEM, TPTE, SOX8, RAP2B, FGF12, GNG11, RAP1A, GNB1, YWHAZ, GNG5, IGBP1, GTF2I, DLG4, CCL20, HLA-DRB3, CCL8, CXCL6, TNFAIP6, VLDLR, ATP2C1, MPP1, NDP, IL9R, CD83, IL5RA, IL1RL1, OCRL, MAP2K1, TEK, CREM, PLAUR, KRT17, TLE1, TLE3, CD164, PRKCD, TYRO3, KHDRBS1, SOS1, IL10RB, PDE4C, PLCXD2, EPS8, ANK3, STK4, TRAF1, MAP2K5, MAPK7, PAK2, CBLB, PTK7, MTA1, ITGB3BP, PPP2R5C, PDE3B, PDCL, PDAP1, IL18R1, NAE1, ITPK1, IQGAP2, TP53BP2, ACVR2B, ALCAM, RAPGEF1, PDE7A, CAMK1, ARHGEF7, SCARF1, GAS6, GRB14, NEDD9, SPARCL1, ITPR2, ITPR1, RASA3, PPP2R5D, ARHGAP19, EBP, PRKD1, PPP2R5A, PTGES3, NECTIN1, PTPRK, RASA2, ERBB4, RALBP1, RPS6KA2, RHEB, TLR1, RPS6KA1, SHB, MAPRE2, TRADD, TRIP10, SMAD1, ZYX, EXT1, PKN1, PKN2, MAPK14, DPYSL2, CARTPT, HIF1A, AMHR2, TXNRD1, HIVEP3, SFRP5, ARHGAP21, GKAP1, PLCXD3, SIGIRR, OR52E8, TENM4, RGMB, ARHGAP11A, SARM1, DTHD1, RASSF6, SYDE1, RAPH1, RASGRP2, CXXC5, PLPPR4, ZFYVE16, MAVS, ARHGAP22, NET1, SRGAP1, TMED4, RASSF3, PDPN, ZDHHC17, NOSTRIN, SLC44A2, RTKN2, UNC5B, TAGAP, ARHGAP24, PLPP5, APPL2, GPRC5A, LILRB1, RASSF8, RIN3, C18orf32, RHPN1, DLG5, MICAL1, SLC20A1, SECTM1, ARAP3, ARAP2, STARD8, SPOCK2, NSMAF, SORL1, ESR2, TFG, STAM, CREBBP, INPP5D, TANK, KIFAP3, CDS1, FGF13, FGF11, FGF14, RIT1, TNFRSF25, EXT2, MR1, ARRDC3, OPTN, PLPPR2, CDKN2AIPNL, ARAP1, INPP4A, DLC1, NR1H4, CSF3R, HBEGF, STAC, P2RX4, DOK1, SMAD5, LITAF, EPAS1, SH3GL2, GDF15, SPOCK3, NDFIP1, SALL3, CD244, TOLLIP, WWP1, BCL11A, RASSF4, SMOC2, SP110, NEK6, PDE7B, PLCB1, KIF13B, DLL4, CDC42SE1, SNX15, KCNIP2, GPR27, NDFIP2, PAG1, SPHK1, FAM13B, VAPA, ARHGAP23, TENM3, PAK7, ARHGAP20, PI4KB, RNF14, LIMD1, ASIC3, LNPEP, CNOT7, PITPNC1, CDC42EP3, PILRA, AMFR, INTS6, MKLN1, CORO1C, APLN, PYCARD, HPCAL4, SUFU, NDRG2, ARHGAP26, SMC3, AKT3, PLAA, RASD1, TNFSF13B, BTRC, PKIG, GOLT1B, STARD13, HBS1L, IRS2, DTNA, CDC42BPB, WIF1, LYVE1, STK24, CSNK1G3, TNFRSF11A |
GO:0007166 | BP | cell surface receptor signaling pathway | A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
TSPAN4, TSPAN6, TSPAN2, ADAP1, ADGRL2, TDP2, TSPAN13, TSPAN12, EGFR, F2, AGT, PRL, CD4, ANXA1, ERBB2, INHA, EDN1, ADRB2, INHBA, CD14, PTPRC, MET, CD28, IFITM1, GP1BB, CCL2, MIF, IL1R1, PRLR, CD36, NPPB, IL7R, LAG3, TSPAN8, CD53, EDN2, CD9, CXCR2, NPY1R, KLRC1, CD27, OXTR, SSTR1, CCKBR, BSG, NUP62, IFNGR2, ADCYAP1R1, TSPAN7, LIFR, MTNR1A, LEPR, CD151, IFNAR2, CSNK1A1, CD97, NPY2R, PTH2R, MTNR1B, AGTR2, TNFSF10, GEM, TIRAP, CD81, PIP4K2B, IRF9, COL4A3, KHDRBS1, TNK2, MERTK, TSPAN31, FADD, BIRC3, ADGRE1, CASP8, NPY5R, MAPK14, LY6E, CTF1, GPR157, JMJD6, ADGRD1, GPR126, ADGRA3, TRPV1, GPR98, TNFRSF25, MAGI1, TSPAN18, DOK1, PRMT1, SEMA6A, ADGRL3, MKNK2, CLCF1, EVL, ADGRG1, CABIN1 |
GO:0007167 | BP | enzyme linked receptor protein signaling pathway | Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription. |
JAK2, CD4, ERBB2, JAK3, GAS6, CNPY2 |
GO:0007168 | BP | receptor guanylyl cyclase signaling pathway | A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription. |
NPPB, NPR2, GUCY2D, GUCA1B |
GO:0007169 | BP | transmembrane receptor protein tyrosine kinase signaling pathway | A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. |
MUSK, CD3EAP, MTSS1, MPZL1, ANGPTL1, NGF, CD4, ERBB2, FYN, CSF1R, LYN, FGR, ERBB3, JAK1, PTPRG, LTK, FLT4, CSK, PIK3CB, ABL2, SYK, SHC2, ROR1, TEK, TNK2, RAPGEF1, ERBB4, STYK1, CSPG4, ABI1, AHI1, BLNK, DOK1, PAG1, DOK5, PILRB, PILRA |
GO:0007171 | BP | activation of transmembrane receptor protein tyrosine kinase activity | Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. |
GREM1, ADRB2, PRLR, EFNA5, NRG1, ANGPT1, PDGFC, PILRB |
GO:0007172 | BP | signal complex assembly | The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. |
PTK2, MAPK8IP2 |
GO:0007173 | BP | epidermal growth factor receptor signaling pathway | A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
PIK3C2A, EREG, SOCS5, RPS6KA5, EGFR, NRAS, KRAS, TGFB1, AREG, ARF4, PIK3R1, BTC, CSK, PIK3CA, EPS15, IQGAP1, SOX9, GRB2, ADAM17, PTK2, PTPN11, SOS1, EFEMP1, EPS8, CBLB, GAB1, REPS2, HBEGF, GAREM1, PAG1 |
GO:0007174 | BP | epidermal growth factor catabolic process | The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor. |
RAB7A |
GO:0007175 | BP | negative regulation of epidermal growth factor-activated receptor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity. |
SOCS5, PSEN1, CBLB, GPRC5A, ERRFI1, SNX6 |
GO:0007176 | BP | regulation of epidermal growth factor-activated receptor activity | Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. |
APP |
GO:0007178 | BP | transmembrane receptor protein serine/threonine kinase signaling pathway | A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. |
ACVR2A, ACVR1B, IRAK1, ACVR2B, BMPR2, LTBP1, MAPK14, AKAP2 |
GO:0007179 | BP | transforming growth factor beta receptor signaling pathway | A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
MSTN, SMAD7, SMAD9, MAP3K7, SMAD6, GDF9, FOS, PDGFB, TGFB1, FSHB, COL3A1, JUN, COL1A2, PARP1, FURIN, UBC, SKI, SKIL, CCL2, HPGD, CREB1, ITGB5, CDH5, BMPR1A, TGFBR1, TGFBR2, ID1, GDF5, UBE2M, RHOA, TGFB2, RPS27A, UBA52, SMAD3, TGFBR3, ACVR1, PTK2, KLF10, BAMBI, ADAM9, SMAD4, PTPRK, TAB1, SMAD2, SMAD1, NEDD8, ZYX, AMHR2, GCNT2, PARD3, SMAD5, CITED1, GDF15, FUT8, HIPK2, PARD6A, DUSP22, MTMR4, NLK, USP15, F11R |
GO:0007181 | BP | transforming growth factor beta receptor complex assembly | The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex. |
TGFBR3, FMOD, EID2 |
GO:0007182 | BP | common-partner SMAD protein phosphorylation | The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus. |
TGFB1, BMP4, TGFBR2, SPTBN1, SMAD2 |
GO:0007183 | BP | SMAD protein complex assembly | The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. |
TGFB1, SMAD3, SMAD4, SMAD2, SMAD1, EID2 |
GO:0007184 | BP | SMAD protein import into nucleus | The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
TGFB1, JUN, GDF5, TGFB2, SPTBN1 |
GO:0007185 | BP | transmembrane receptor protein tyrosine phosphatase signaling pathway | A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription. |
PTPRF, PTPRD, FRS2 |
GO:0007186 | BP | G-protein coupled receptor signaling pathway | A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). |
GPR37, GNG7, FZD6, JAK2, RAMP1, FZD7, TULP3, GPR32, LGR5, GABBR2, ABCA1, ADGRL2, AGT, C3, PTH, GCG, INS, APOA1, APOE, APOC3, PPBP, PF4, OPN1SW, GNAI2, EDN1, INSR, CHRM2, CXCL1, PDGFRB, CXCL8, CCL3, IGF2R, CCL4, CCL2, CCL5, RAC2, VAV1, AREG, GNB3, ADRA2B, CXCL2, CHRM3, PDC, S1PR1, FPR1, LHCGR, FSHR, FPR2, ADRA1D, EDNRA, PTAFR, F2R, ADORA2B, AGTR1, OXTR, GNRHR, AKT1, GPR183, SSTR5, ADRA1A, HRH1, ADRA1B, PPARG, ADCYAP1R1, HTR2B, AKR1C3, PIK3CB, CXCL5, PTGFR, PTGER3, PTGER2, OR3A3, CXCL12, NPBWR1, NMU, PIK3CG, CD97, PTH2R, RGS7, AGTR2, GNG4, AKR1C2, F2RL1, CXCR4, GNG11, CALM2, GNB2, RAC1, GNAI1, GNG5, CCL20, CCL8, CXCL6, GPSM2, MC2R, GNA12, APLP2, AKAP13, PTGDR, ENPP2, ADGRE1, GPR176, ITPR3, P2RY14, NPY5R, CARTPT, SFRP5, GPR158, GPR157, ATRNL1, SFRP4, OR52E8, RGS7BP, ADGRD1, PREX2, GPR126, ADIPOR2, TPRA1, ADGRA3, SFRP1, GPRC5A, NPB, OR5A2, OR5L2, OR14C36, FRS2, GPR98, RAPGEF4, GHSR, KISS1R, ADIPOR1, GPR146, OR2A5, S1PR3, GPER1, INPP5K, TM2D1, LGR4, GPR63, OPN3, OR51E2, FZD8, ADGRL3, LGR6, ACKR4, GPRC5C, GPR27, CELSR3, GPRC5B, GHRL, GPR160, FZD4, GPR34, RASD1, ADGRG1 |
GO:0007187 | BP | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. |
ANXA1, CHRM2, CCL2, ADRB3, CNR1, LHCGR, NPY1R, SSTR1, HTR7, SSTR5, MTNR1A, NPBWR1, MTNR1B, MC2R, HRH3 |
GO:0007188 | BP | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). |
GCG, ADRB2, CHRM2, ADRB3, FPR1, CNR1, ADRA1D, AVPR2, MC4R, GRK5, ADRA1B, PTGER4, GNAI1, GNA12, WASF2 |
GO:0007189 | BP | adenylate cyclase-activating G-protein coupled receptor signaling pathway | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). |
ADCY3, ADCY9, PTH, GHRH, PTHLH, LHCGR, FSHR, ADORA2B, PTGER4, PTGFR, PTGER2, GNAQ, ADCY7, GNAS, GNAS |
GO:0007190 | BP | activation of adenylate cyclase activity | Any process that initiates the activity of the inactive enzyme adenylate cyclase. |
ADCY3, ADCY9, RAF1, ADRB2, ADRB1, ADRB3, PRKCA, LHCGR, FSHR, EDNRA, ADORA2B, AVPR2, ADCY7, CALM2 |
GO:0007191 | BP | adenylate cyclase-activating dopamine receptor signaling pathway | The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). |
GNB1, GNAS, GNAS |
GO:0007192 | BP | adenylate cyclase-activating serotonin receptor signaling pathway | The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). |
HTR7 |
GO:0007193 | BP | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
GPR37, ADCY3, ADCY9, GNAI2, PSAP, GNAI3, NPR3, S1PR1, NPY1R, HTR2C, ADORA1, OPRL1, HTR2B, NPY2R, ADCY7, GNAI1, S1PR3, GABBR1 |
GO:0007194 | BP | negative regulation of adenylate cyclase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity. |
GABBR2, GNAI2, GNAI3, DRD2, PRKCA, GRM3, GABBR1 |
GO:0007195 | BP | adenylate cyclase-inhibiting dopamine receptor signaling pathway | The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
DRD2, FLNA |
GO:0007196 | BP | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway | The series of molecular signals generated as a consequence of a G-protein coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
GRM8, GRM6, GRM3 |
GO:0007197 | BP | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway | The series of molecular signals generated as a consequence of a G-protein coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
CHRM2, CHRM3, HRH3 |
GO:0007199 | BP | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP). |
AGT, AGTR2 |
GO:0007200 | BP | phospholipase C-activating G-protein coupled receptor signaling pathway | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
GPR32, AGT, ESR1, NPR3, FPR1, C5AR1, LHCGR, CXCR2, FPR2, ADRA1D, F2R, HTR2C, AGTR1, CCKBR, ADRA1A, HRH1, ADRA1B, HTR2B, PTGER3, GNB1, KISS1R |
GO:0007202 | BP | activation of phospholipase C activity | The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. |
EGFR, AGT, ANG, SELE, C5AR1, EDNRA, ADRA1A, ADCYAP1R1, HTR2B, GNAQ, PRKCD |
GO:0007204 | BP | positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
JAK2, GPR32, LRP6, AGT, KNG1, ESR1, EDN1, CD55, NMB, HMGB1, SAA1, PDGFRA, CD36, GJA1, EDN2, FPR1, C5AR1, CXCR2, CD24, FPR2, ADRA1D, EDNRA, F2R, AGTR1, OXTR, CCKBR, ADM, ADRA1A, ADRA1B, PTGER4, OPRL1, ABL2, PTGFR, PTGER3, PTGER2, PIK3CG, NPY2R, BCAP31, F2RL1, CXCR4, GNB1, DLG4, PKD1, PTGDR, CACNA1C, ITPR3, SPPL3, TRPM4, S1PR3, GPER1, C1QTNF1, TRPV4, GHRL, TRPC6 |
GO:0007205 | BP | protein kinase C-activating G-protein coupled receptor signaling pathway | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). |
PLPP1, EDN1, CCK, GAP43, F2R, HTR2B, DGKZ, DGKK, DGKH, PARD3 |
GO:0007206 | BP | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway | The series of molecular signals generated as a consequence of a G-protein coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
HOMER1 |
GO:0007207 | BP | phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway | The series of molecular signals generated as a consequence of a G-protein coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
CHRM2, CHRM3, HRH3 |
GO:0007208 | BP | phospholipase C-activating serotonin receptor signaling pathway | The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
HTR2C |
GO:0007210 | BP | serotonin receptor signaling pathway | The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. |
HTR2C, HTR2B |
GO:0007212 | BP | dopamine receptor signaling pathway | The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. |
GNAI3, NSG1, GSK3B |
GO:0007213 | BP | G-protein coupled acetylcholine receptor signaling pathway | Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription. |
RGS10, GNAI2, CHRM2, CHRM3, GNA11, GNAQ, GNB1, PLCB1 |
GO:0007214 | BP | gamma-aminobutyric acid signaling pathway | The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor. |
GABBR2, GNAI2, ATF4, GABRA5, SLC12A2, PLCL1, GABBR1, PLCL2 |
GO:0007215 | BP | glutamate receptor signaling pathway | A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
SSTR1, GRIA4, GNAQ, FMR1, GRIN2A, PLCB1 |
GO:0007216 | BP | G-protein coupled glutamate receptor signaling pathway | A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. |
GRM6, HOMER3 |
GO:0007217 | BP | tachykinin receptor signaling pathway | The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor. |
GRK5 |
GO:0007218 | BP | neuropeptide signaling pathway | The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. |
AGRP, CRCP, NXPH3, ECEL1, POMC, PENK, SCG5, NMB, CPE, GAL, NPY1R, SSTR1, OPRL1, NPBWR1, GLRB, NMU, NPY2R, MC2R, NPY5R, CARTPT, NPB, KISS1R |
GO:0007219 | BP | Notch signaling pathway | A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
NEURL1B, ADAM10, ITGB1BP1, SNAI2, GMDS, MYC, TGFB1, APP, KRT19, ANXA4, UBC, BMP2, AGXT, MDK, PLN, TGFBR2, CDKN1B, NOTCH1, SOX9, PSEN1, PSEN2, ASCL1, CDH6, RPS27A, UBA52, JAG1, ADAM17, CDK6, HHEX, NOTCH2, EP300, CNTN1, FOXC1, HES1, NR0B2, ZNF423, NOTCH2NL, MIB1, MAML2, NKAP, DNER, APH1B, CREBBP, KAT2B, MIB2, APH1A, PERP, ITCH, MAML3, RITA1, IFT74, NR1H4, SPEN, S1PR3, CHAC1, WDR12, HEYL, DLL4, SEL1L, HEY1 |
GO:0007220 | BP | Notch receptor processing | The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. |
ADAM10, PSEN1, PSEN2, JAG1, ADAM17, DNER, APH1B, APH1A, DLL4 |
GO:0007221 | BP | positive regulation of transcription of Notch receptor target | The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain. |
NOTCH1, MAML2, MAML3, RBM15 |
GO:0007223 | BP | Wnt signaling pathway, calcium modulating pathway | The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). |
MAP3K7, FZD6, NFATC1, CTNNB1, WNT5A, CALM2, GNB1, PPP3CA, TNRC6A, TNRC6C, AGO4, PLCB1, TCF7L2, NLK, AGO2, FZD4, TNRC6B |
GO:0007224 | BP | smoothened signaling pathway | A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. |
C21orf2, GLI2, GLI3, TROVE2, BMP4, TGFBR2, NDST1, EVC, PTCH1, HES1, SEPT2, STIL, NSDHL, TCTN3, BBS7, GPC2, IQUB, DYRK2, DISP1, TCTN2, PTCHD1, HHIP, IFT27, HIPK2, CENPJ, IFT46, CC2D2A, B9D1, HSPB11 |
GO:0007225 | BP | patched ligand maturation | The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups. |
DISP1 |
GO:0007227 | BP | signal transduction downstream of smoothened | The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway. |
IFT122 |
GO:0007229 | BP | integrin-mediated signaling pathway | A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
ADAM10, ITGB1BP1, TYROBP, SEMA7A, ITGA10, COL3A1, APOA1, ITGB3, ITGB2, ITGB1, ITGAV, ITGA5, FGR, ITGAM, VAV1, ITGB4, ITGA2, ITGB5, ITGAX, NME2, ITGA6, ITGA3, ITGB8, CTGF, MYH9, ITGAE, SYK, PLP1, DST, PTK2, PTPN11, COL16A1, CD47, CDH17, ILK, ADAM9, CUL3, ITGA9, NEDD9, PRKD1, ZYX, CCM2, FUT8, ADAMTS1, VAV3, ITGA11 |
GO:0007231 | BP | osmosensory signaling pathway | The series of molecular signals initiated in response to osmotic change. |
OSR1, TRPV4 |
GO:0007249 | BP | I-kappaB kinase/NF-kappaB signaling | The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
TLR4, TLR3, IRAK2, MAP3K7, RIPK2, ROCK2, BCL10, TNF, CD14, UBC, NFKB1, BCL3, AVPR2, RPS27A, UBA52, RELB, REL, BIRC3, RIPK1, TRADD, TAB1, IRAK1BP1, TAB3, ZNF675, TANK, AZI2, NKIRAS1, HACD3, NFKBIL1, TBK1 |
GO:0007250 | BP | activation of NF-kappaB-inducing kinase activity | The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. |
TLR3, MAP3K7, CHI3L1, IRAK1, TIRAP, ZFP91, COPS8, CARD10 |
GO:0007252 | BP | I-kappaB phosphorylation | The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
TLR4, TLR3, MAP3K7, TLR2, PRDX4, ERC1 |
GO:0007253 | BP | cytoplasmic sequestering of NF-kappaB | The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. |
PSMD10, IL10, G3BP2, FAF1 |
GO:0007254 | BP | JNK cascade | An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
MAP2K7, IRAK2, MAP3K13, MAP3K7, RIPK2, TNF, UBC, ADORA2B, PTGER4, MAPK8, MAPK9, CRKL, IRAK1, RPS27A, UBA52, GPS2, MAPK8IP2, TAB1, MAP4K3, MINK1, TAB3, TRIB1, MAP3K5, DUSP9, TNFRSF19, DUSP10 |
GO:0007256 | BP | activation of JNKK activity | The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress. |
NRK, TNIK |
GO:0007257 | BP | activation of JUN kinase activity | The initiation of the activity of the inactive enzyme JUN kinase (JNK). |
MAP2K7, TNFSF11, AXIN1, SPAG9, ERN1, CD40LG, WNT5A, SYK, GAB1, RIPK1, PKN1, MLK4, MAP3K5, MDFI, ZAK, HACD3, MAPK8IP3, MAP4K5 |
GO:0007258 | BP | JUN phosphorylation | The process of introducing a phosphate group into a JUN protein. |
MAPK8, MAPK9, MAPK8IP1 |
GO:0007259 | BP | JAK-STAT cascade | Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. |
SOCS2, SOCS3, SOCS6, SOCS1, JAK2, SOCS5, STAMBP, GH1, GHR, CCL2, IFNAR1, STAT3, STAT5A, IFNAR2, STAT5B, STAT2, PKD1, NMI, PKD2, CLCF1 |
GO:0007260 | BP | tyrosine phosphorylation of STAT protein | The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. |
JAK2, F2R, LEP, JAK3 |
GO:0007262 | BP | STAT protein import into nucleus | The directed movement of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases. |
JAK2, F2R, JAK3, HES1 |
GO:0007263 | BP | nitric oxide mediated signal transduction | Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. |
DDAH1, DDAH2, AGT, APOE, CD36, FPR1, NOS3, NPY2R, AGTR2, MT1X, NDNF, RASD1 |
GO:0007264 | BP | small GTPase mediated signal transduction | Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. |
RAB27B, KRIT1, ARHGAP33, RAB29, SIAH2, DAB1, BCAR3, RHOBTB3, DIRAS3, HMOX1, RAC2, VAV1, RHOQ, ARF4, RAB3B, RAB5A, CHM, CHML, TRIM23, ARL4D, GDI2, RAB5C, RAB7A, RAB9A, RAB28, RAB27A, RAP1GDS1, GEM, RRAD, RAC3, CDC42, RAB4B, RAB2A, RAB5B, RAB11A, RAB1A, RAC1, ARF1, ARF5, SOS2, TNK2, ARL16, RAB40B, ABR, PLD1, RAB31, RAB32, RAB33A, RALBP1, RHEB, ITSN1, RAB11B, ARHGAP31, RABL6, RALGPS1, DOCK11, RAB12, KNDC1, ARHGAP30, RALGPS2, ARL17A, RASEF, ARHGAP18, ARL14, DOCK8, RHEBL1, RAB2B, RIN2, RAPGEF4, DOCK2, RAB8B, RERG, ARL8A, DOCK10, RASD2, RAB39B, DOCK6, ARL5B, DOCK7, RASL10B, CHP1, RASL11B, IFT27, RAB34, RAB1B, DOCK5, RRAGC, RAB6B, ARL8B, NKIRAS1, RGL1, DNAJC27, HACD3, VAV3, RAB21, RAB22A, RAB23, AGAP1, RASD1, MFHAS1, SRPRB, ARL5A |
GO:0007265 | BP | Ras protein signal transduction | A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
SDCBP, NRAS, KRAS, TP53, IGF1, JUN, RB1, FGF2, RRAS, RALA, RALB, CCNA2, CDK2, DNMT1, CDKN1A, CRKL, MAPKAPK2, RRAS2, GNB1, GRB2, SHC2, SOS1, RALGDS, TRIM28, G3BP1, PLD1, PRKD1, DHCR24, MAPK14, RASGRP2, IQGAP3, RAPGEF6, RIT1, SYNGAP1, USP28, DOK1, RASSF1, PLK2, G3BP2 |
GO:0007266 | BP | Rho protein signal transduction | A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. |
RHOD, TAX1BP3, ARHGAP6, ROCK2, PTH, COL1A2, CFL1, AGTR1, BCL6, CDH13, SYNJ2BP, RHOA, RHOB, GNA12, ARHGAP5, MYO9B, ARHGAP29, PHACTR4, RHOJ, ARHGEF3, HACD3, CTNNAL1, CDC42EP3, ADGRG1 |
GO:0007267 | BP | cell-cell signaling | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
CYR61, ADAM10, NRP1, EREG, DHH, FADS1, GREM1, TUSC2, WISP2, FGF18, MPZL1, WISP1, CXCL14, NUDT3, AGT, NGF, GNRH1, POMC, CGA, LHB, PTH, GHRH, INS, IL1B, C1QA, AMH, PDGFA, ITGB2, INHA, EDN1, PGR, S100A9, ADRB2, INHBA, ADRB1, NMB, WNT2, CCL3, AR, TXN, IAPP, PTHLH, BMP2, BMP3, CCL4, CCL5, ADRB3, AREG, GJA1, ADRA2B, CD33, TRH, IL11, EFNA1, FGFR2, IL10, BDNF, ADRA1D, PCSK1, CTGF, ADORA1, SSTR1, SRD5A2, FGF9, ADM, ADRA1A, ADRA1B, CXCL5, GDF5, NAMPT, GATA4, CD97, PGF, TNFSF10, INSL3, EFNA4, EFNB2, FGF12, TGFB2, GRB2, CCL20, CCL8, CXCL6, CRB1, TNFAIP6, NDP, TEK, PCDH1, BST2, MERTK, KLF10, SEMA3B, SEMA5A, IL18, FAT1, ZYX, CARTPT, CTF1, FJX1, CHST4, ESR2, PCSK5, FGF13, FGF11, FGF14, PANX1, PKP4, GDF15, TOLLIP, ASH1L, STAB1, LNPEP, GUCA1B, ADGRG1, TNFRSF11A |
GO:0007268 | BP | chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
SDCBP, DLGAP1, KCNK3, GRM6, CACNA1G, LRP6, GABBR2, GLS, PENK, CNP, PTPRF, SYN1, SYT1, CBLN1, PTPRD, HTR2C, MAPK1, SLC6A1, CHRNA5, SSTR1, GABRA5, HTR7, CTNNB1, SSTR5, GJC1, OPRL1, HTR2B, SLC1A3, SLC1A2, NPTX2, GRIA4, NPBWR1, GLRB, SLC1A6, NPY2R, MTNR1B, PPT1, NOVA1, ATXN3, CACNB3, PLP1, SNAP25, FGF12, DLG4, CDK5, PMP22, APBA1, SLC18A2, KCNA1, GRIN2A, DLG1, UNC119, GPR176, GRM3, NPY5R, CACNA1E, ASIC2, CARTPT, HOMER1, MINK1, SYN2, CEP89, PDE7B, KCNIP2, NRXN1, MYO5A, DTNA, PCDHB9, PCDHB3, PCDHB14 |
GO:0007269 | BP | neurotransmitter secretion | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission. |
CASK, SNAPIN, SYN1, SYT1, PPT1, SNAP25, STXBP1, VAMP2, APBA1, SLC18A2, PDZD11, SYN2, LIN7B, LIN7C, NRXN1, HRH3 |
GO:0007270 | BP | neuron-neuron synaptic transmission | The process of communication from a neuron to another neuron across a synapse. |
KIF1B, DRD2, PTEN |
GO:0007271 | BP | synaptic transmission, cholinergic | The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine. |
APOE, CHRM2, CHRNB1, NQO1, CHRM3, CHRNA5, CHRNA7, LYPD1, HRH3 |
GO:0007274 | BP | neuromuscular synaptic transmission | The process of communication from a neuron to a muscle, across a synapse. |
KIF1B, FCHSD2, CHRNB1, CHRNA5, ETV5, STXBP1, EGR3, DTNA |
GO:0007275 | BP | multicellular organism development | The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). |
CNOT1, WIPF3, HACD1, ENC1, TNFRSF10C, MUSK, HMGB3, EDIL3, EDF1, DIAPH2, MITF, GADD45B, CREG1, RECQL4, WDR47, GADD45G, ZBTB7A, EYA4, ZMYM6, CLPTM1, F2, GNRH1, IGF2, TP53, CSF1R, ZFY, PAEP, BMP1, VCAN, LIF, HIVEP1, ZFX, TNFRSF1B, MAK, RPS4Y1, MMP11, ADRA1D, LMO2, TNFRSF8, GNRHR, HOXA10, HIVEP2, ADRA1B, LTBR, SERPINF1, GPX4, LEPR, HOXA1, MEOX1, PLXNA3, ARHGDIB, AGFG1, HMGA2, EMP1, KLF3, TPI1, DCAF7, ELF3, DAB2, CENPE, ID2, ID3, CREM, NOTCH2, TLE1, CD164, MXD1, MCL1, AES, MN1, BST2, CUX1, CDK13, ZMYM3, DIP2A, PSME4, PCOLCE, ELAVL1, CSRP2, HLF, QRICH1, ODF2, HIVEP3, SFRP5, TMEM198, SFRP4, DPY19L2, SHISA2, LCLAT1, SLCO4C1, TSHZ1, NOTCH2NL, PIWIL4, SPRED1, ZSCAN2, SPATA24, C19orf68, ERC1, TMEFF1, GCNT2, MTURN, MINK1, BANP, TRIML1, LSM14A, TDRD9, PHC3, SPATA20, SLC2A14, FAT3, PAQR8, CHURC1, EDARADD, FAM3C, TNFRSF25, PTP4A1, PBXIP1, CREB3L1, KAZALD1, GMCL1, ST6GAL2, ZFR, STRBP, MNT, APOL2, SPATA9, SPRY4, PDGFD, PDLIM7, TSHZ2, OLFML3, DUSP22, HELLS, MBNL3, ASF1B, PAQR5, DONSON, FMN2, EHF, GRHL1, DSPP, ADAMTS9, THEG, DKK2, ZMYM2, CFDP1, PLEKHB1, DMBT1, LIMD1, DACH1, PLXNA1, ZMYM5, TUBD1, OSGIN1, TCFL5, SUFU, PRELID1, INVS, DRG1, CHST2, RNF114, WIF1, SPIN1, POMT1 |
GO:0007276 | BP | gamete generation | The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. |
CTDNEP1, WNT3, SMAD1, SPIN4, FANCD2, ZNF148, SPIN1 |
GO:0007281 | BP | germ cell development | The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. |
ANGPT2, BMP4, WT1, AKT1, MSH2, ACVR1, BAX, SMAD5, LIN28A |
GO:0007283 | BP | spermatogenesis | The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis. |
MEIOC, WIPF3, ARNTL, RAD51C, BCL2L11, SPAG9, KHDRBS3, CRTAP, SBF1, PTTG1, APOB, SLC4A2, SERPINA5, ERCC1, AR, KIT, IGF2R, SKIL, ACE, CCNB1, H2AFX, MAK, CNR1, ATP2B4, FSHR, BRD2, YY1, ACVR2A, CALR, KDM5A, CDC25C, SSTR1, HOXA10, DNAJA1, KRT9, NUP62, MLH1, BCL6, RGS2, ADCYAP1R1, ATRX, NOTCH1, SOX9, INSL3, BCAP31, BRCA2, NR0B1, LIMK2, PRKAG1, RAD23B, SOX8, BTG1, UBE2B, PAFAH1B2, CCNA1, CDK16, HSF1, E2F1, HIST1H1A, CREM, TYRO3, MERTK, PRDX4, SMAD4, BIRC3, CCNI, FAM50A, WFDC2, PUM1, ACOX1, PAFAH1B3, RGN, SPA17, TESK1, TRIP13, ARID4B, MORN2, HERC4, ALKBH5, SLCO4C1, SETX, PIWIL4, ZSCAN2, SPATA24, TDRP, SIAH1, ASPM, TDRD9, MNS1, WDR48, SPATA20, KIAA1524, SLC2A14, IFT81, BCL2L2, BAD, TMEM203, RPL39L, DAZAP1, GMCL1, MYCBP, PAIP2, HERPUD2, NDC1, KIFC1, SPATA9, LGR4, TEX15, CADM1, EIF5A2, RACGAP1, SOX17, USP42, PATZ1, SPAG4, PARP11, CYP26B1, DIAPH3, ASF1B, DNAH9, THEG, DUSP13, TUBD1, TCFL5, CDYL, RUVBL1, RNF114, PCYT1B |
GO:0007286 | BP | spermatid development | The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. |
FANCG, DHH, RNF8, KIT, RFX2, SMARCA2, H3F3A, NSUN2, TRIP13, STK11, ODF2, DPY19L2, CEP57, RSPH1, PACRG, QKI, STRBP, CIB1, JAM3, PANK2, SLIRP, IQCG, MKKS, NECTIN3, AFF4 |
GO:0007288 | BP | sperm axoneme assembly | The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement. |
UBE2B, BBS2, IQCG |
GO:0007289 | BP | spermatid nucleus differentiation | The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. |
HMGB2, AGFG1, TMF1, PYGO2, GOPC |
GO:0007292 | BP | female gamete generation | Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. |
GDF9, DIAPH2, PARN, BMP15, FSHB, FSHR, DYNLL1, TOB2, MCM8 |
GO:0007296 | BP | vitellogenesis | The production of yolk. Yolk is a mixture of materials used for embryonic nutrition. |
FOSL1, SOS1, ZMIZ1 |