| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0006579 | BP | amino-acid betaine catabolic process | The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid. |
DMGDH |
GO:0006580 | BP | ethanolamine metabolic process | The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). |
CHKA |
GO:0006582 | BP | melanin metabolic process | The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. |
BCL2 |
GO:0006583 | BP | melanin biosynthetic process from tyrosine | The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine. |
TYR |
GO:0006584 | BP | catecholamine metabolic process | The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. |
AOC2, SULT1A3, MTPN |
GO:0006585 | BP | dopamine biosynthetic process from tyrosine | The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine. |
TH |
GO:0006590 | BP | thyroid hormone generation | The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. |
DIO2, SLC5A5, DUOX2, DUOX1, CPQ |
GO:0006592 | BP | ornithine biosynthetic process | The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. |
ALDH18A1 |
GO:0006595 | BP | polyamine metabolic process | The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. |
OAZ2, ODC1, AMD1, SRM |
GO:0006596 | BP | polyamine biosynthetic process | The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. |
OAZ2, SAT1, OAZ1 |
GO:0006597 | BP | spermine biosynthetic process | The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. |
AMD1 |
GO:0006600 | BP | creatine metabolic process | The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. |
GHR, CKB, CKMT1A, CKMT2, STAT5A, SLC6A8, GATM, STAT5B |
GO:0006601 | BP | creatine biosynthetic process | The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle. |
GATM |
GO:0006605 | BP | protein targeting | The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. |
MYO1C, RHOD, TRAK2, RASSF9, YWHAB, RAB27A, SYNJ2BP, YWHAE, RPL11, YWHAZ, AKAP6, OS9, CDC37, PAN3, NLGN1, SORL1, KATNB1, HPS4, KIF13B, HOMER3, TRAK1 |
GO:0006606 | BP | protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
NUP155, PDIA3, FGF9, NUP62, STAT3, RANBP1, NUP153, TSC2, PTTG1IP, CSE1L, NUP107, NUTF2, RAE1, PPP3CA, KPNB1, C11orf73, NUP93, TMCO6, PRICKLE1, IPO9, PPP1R10, NUP88, NUP58, NUP85, NUP62CL, TXNIP, NUP50 |
GO:0006607 | BP | NLS-bearing protein import into nucleus | The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. |
IPO5, KPNA3, KPNA4, TNPO2, FYB, KPNA5, RANBP6, RANBP2, KPNA2, KPNA1, CBLB, DAG1, KPNB1, NUP35, IPO4, RERE, TRPS1 |
GO:0006610 | BP | ribosomal protein import into nucleus | The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. |
IPO5, TNPO2, RANBP6, KPNB1, IPO4 |
GO:0006611 | BP | protein export from nucleus | The directed movement of a protein from the nucleus into the cytoplasm. |
XPO1, NUPL2, AHCYL1, TGFB1, EGR2, CALR, GSK3B, CSE1L, NUTF2, EIF5A, CRB1, PKD1, NUP88, CHP1, XPO4, STRADB, NXT1 |
GO:0006612 | BP | protein targeting to membrane | The process of directing proteins towards a membrane, usually using signals contained within the protein. |
MYO1C, SDCBP, ICMT, CHM, ADORA1, PRKCI, PARD3, RAB3IP, SEC63, RABGEF1, TAOK2 |
GO:0006613 | BP | cotranslational protein targeting to membrane | The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria. |
SRP14, SSR1, TRAM2, ARL6IP1, SEC62 |
GO:0006614 | BP | SRP-dependent cotranslational protein targeting to membrane | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
SRP72, RPLP1, RPLP2, RPLP0, RPS17, RPSA, RPS2, RPL35A, RPL7, RPL17, RPS4Y1, RPL13, RPL10, RPL12, RPL22, RPL4, SRP14, RPL13A, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, RPL29, RPL34, SRP9, RPL14, RPS20, SRP54, RPS3A, RPL26, RPL15, RPL27, RPL37A, SEC61A1, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS25, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, UBA52, RPL38, RPS21, RPL24, RPL36A, RPL19, RPL18A, RPL18, SEC63, SSR3, RPL36, SRPRB |
GO:0006616 | BP | SRP-dependent cotranslational protein targeting to membrane, translocation | The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen. |
SRP9, SRP54, ZFAND2B |
GO:0006617 | BP | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition | The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting. |
SRP54 |
GO:0006620 | BP | posttranslational protein targeting to membrane | The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. |
SEC61A1, SEC62, CHMP4B, SEC63 |
GO:0006621 | BP | protein retention in ER lumen | The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. |
KDELR3, KDELR1, PDIA3, OS9 |
GO:0006622 | BP | protein targeting to lysosome | The process of directing proteins towards the lysosome using signals contained within the protein. |
RAB7A, SNX16, NCOA4, ZFYVE16, SORL1, NAGPA, AP3M1 |
GO:0006623 | BP | protein targeting to vacuole | The process of directing proteins towards the vacuole, usually using signals contained within the protein. |
GOSR2, VPS13C, PIK3R4, VTI1B |
GO:0006625 | BP | protein targeting to peroxisome | The process of directing proteins towards the peroxisome, usually using signals contained within the protein. |
PEX12, ZFAND6, LONP2 |
GO:0006626 | BP | protein targeting to mitochondrion | The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. |
AIP, TIMM23, TIMM17B, MFN2, TOMM40, TSPO, BID, TOMM20, TOMM5, MGARP, DNAJC19, TRNT1, TIMM17A, MFF, TOMM22, TOMM7, TIMM10B |
GO:0006627 | BP | protein processing involved in protein targeting to mitochondrion | The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments. |
PMPCA, MIPEP |
GO:0006629 | BP | lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
PLPP1, PLPP3, TPP1, MGST3, PLIN1, ACSL4, SC5D, CH25H, LDLR, APOC1, APOD, CYP3A4, CLU, G6PD, PC, CD36, IL1RN, PTGS1, NR2F2, AOAH, CHKA, HMGCL, SREBF1, PPARG, LEP, ALDH3B2, PITPNB, FABP6, UCP3, PAFAH1B2, LRP2, PITPNA, FABP5, HMGCS1, OCRL, PPARD, PPARA, SREBF2, PDE3A, STARD3, ACOX1, PAFAH1B3, PLCL1, PLA1A, TECRL, SLC27A4, BTN2A1, NPHP3, LRP10, JAZF1, TPRA1, CNEP1R1, TRPV1, ABHD4, OMA1, FAR2, MGLL, HSD17B10, APOL2, ACAT2, OSBPL10, MID1IP1, GDE1, PEMT, PLCL2, LIPT1, LIPG, CEPT1 |
GO:0006631 | BP | fatty acid metabolic process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
NDUFS6, LYPLA1, LYPLA2, C3, FABP3, TH, GHR, PRKAR2B, SNCA, STAT5A, ACADSB, FASN, STAT5B, UCP3, CREM, PPARA, MSMO1, AASDH, THEM4, FA2H, GPAT4, AACS, ABHD5, ALKBH7, MECR, GPAM, PNPLA8, CROT, CRYL1 |
GO:0006633 | BP | fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
HACD1, ACACB, NDUFAB1, SC5D, CH25H, LPL, XBP1, ABCD3, BRCA1, FASN, PRKAG1, PRKAA2, MSMO1, ACSM3, HSD17B12, FA2H, MGLL, MECR, ELOVL4, PRKAG3 |
GO:0006635 | BP | fatty acid beta-oxidation | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
SLC27A2, SLC25A17, ECI2, ABCD3, ECHS1, LEP, ECI1, ACADVL, CPT1A, HSD17B4, HADHB, SESN2, PPARD, ECH1, AUH, ADIPOQ, DECR1, HADH, HIBCH, ECHDC2, CPT1B, BDH2, ACAT2, CROT |
GO:0006636 | BP | unsaturated fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. |
ELOVL7, SCD, FADS1, FADS2, SCD5, ELOVL1, ELOVL4, ELOVL6, ELOVL5 |
GO:0006637 | BP | acyl-CoA metabolic process | The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. |
ACOT8, HMGCL, GPAT4, ACOT4, GPAM, ACSL6, ACOT9 |
GO:0006638 | BP | neutral lipid metabolic process | The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. |
SNCA |
GO:0006641 | BP | triglyceride metabolic process | The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. |
INSIG1, ACSL4, APOE, APOA2, APOC1, APOC3, APOH, CYP2E1, LPL, GPX1, GK, ACSL1, G6PC, CPT1A, CAV1, PTPN11, APOBR, APOA5, PCSK9, LMF1, SEL1L |
GO:0006642 | BP | triglyceride mobilization | The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism. |
APOB, LPIN1 |
GO:0006643 | BP | membrane lipid metabolic process | The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. |
B4GALT4 |
GO:0006644 | BP | phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
PLPP1, PLPP3, APOA1, LPL, PLA2G2A, GPX4, SNCA, PLA2G5, NKX2-1, PLA2G4A, PLCD1, PLA2G16, PLPPR4, PCSK9, PLPP5, ABHD4, GATA6, PLPPR2, ACP6, LGALS13, PLA2G4C, PLAA |
GO:0006646 | BP | phosphatidylethanolamine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
ALOX15, CHKA, LPIN1, SLC27A1, PCYT2, EPT1, ETNK1, CHKB, CEPT1 |
GO:0006650 | BP | glycerophospholipid metabolic process | The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. |
GNPAT, PEMT |
GO:0006651 | BP | diacylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. |
ANG |
GO:0006654 | BP | phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
GNPAT, PLA2G2A, PLA2G5, PLA2G4A, PLD1, GPAT3, SLC27A1, LCLAT1, GPAT4, ABHD5, PLA2G12A, GPAM, AGPAT4, AGPAT3 |
GO:0006655 | BP | phosphatidylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. |
CDS2, PGS1, SLC27A1, CDS1 |
GO:0006656 | BP | phosphatidylcholine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
APOA1, APOA2, CHKA, PCYT1A, FABP5, LPIN1, SLC27A1, GPAT4, SLC44A2, SLC44A3, SLC44A5, SLC44A1, PEMT, CHKB, PCYT1B, CEPT1 |
GO:0006657 | BP | CDP-choline pathway | The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. |
CHKA, PCYT1A, CDS1, CHKB, PCYT1B, CEPT1 |
GO:0006658 | BP | phosphatidylserine metabolic process | The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. |
SERINC3, PLA1A, SERINC5, SERINC2, SERINC1 |
GO:0006659 | BP | phosphatidylserine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. |
PLSCR1, PTDSS1, SLC27A1 |
GO:0006660 | BP | phosphatidylserine catabolic process | The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. |
ABHD12 |
GO:0006661 | BP | phosphatidylinositol biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
PIK3CD, PIK3C2A, PIP5K1B, SYNJ2, INPP4B, SYNJ1, PIP5K1C, FGF2, PLCG2, PIK3R1, IMPA1, PIK3CA, PIK3CB, PIK3CG, PTEN, PIP4K2B, ARF1, OCRL, MTM1, MTMR1, MTMR2, SLC27A1, PIK3C3, INPP5D, CDS1, SH3YL1, INPP4A, PIK3R4, INPP5K, INPP5E, MTMR4, PI4KB, PIKFYVE |
GO:0006662 | BP | glycerol ether metabolic process | The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. |
TXN, TXN2 |
GO:0006663 | BP | platelet activating factor biosynthetic process | The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. |
PLA2G5, PLA2G4A, LPCAT2 |
GO:0006664 | BP | glycolipid metabolic process | The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent. |
KDELC1, KDELC2, ST6GALNAC4, ST3GAL6 |
GO:0006665 | BP | sphingolipid metabolic process | The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
TH, SERINC3, SERINC5, SERINC2, SERINC1 |
GO:0006670 | BP | sphingosine metabolic process | The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. |
SGPP2, SPHK1 |
GO:0006672 | BP | ceramide metabolic process | The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. |
PPP2R1A, CLN3, ASAH1, ORMDL2, NSMAF |
GO:0006678 | BP | glucosylceramide metabolic process | The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative. |
CLN3 |
GO:0006679 | BP | glucosylceramide biosynthetic process | The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. |
UGCG |
GO:0006680 | BP | glucosylceramide catabolic process | The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. |
GBA2 |
GO:0006681 | BP | galactosylceramide metabolic process | The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. |
CLN3 |
GO:0006683 | BP | galactosylceramide catabolic process | The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. |
GALC |
GO:0006684 | BP | sphingomyelin metabolic process | The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. |
CLN3 |
GO:0006685 | BP | sphingomyelin catabolic process | The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. |
SMPD4 |
GO:0006686 | BP | sphingomyelin biosynthetic process | The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. |
SPTLC2, SGMS1, SGMS2 |
GO:0006687 | BP | glycosphingolipid metabolic process | The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. |
HEXA, PSAP, STS, KIT, ARSA, ARSB, GM2A, ARSD, GALC, CREM, BAX, ASAH1, UGCG, ARSK, SUMF1, NEU1, GBA2, SMPD4, GLTP |
GO:0006688 | BP | glycosphingolipid biosynthetic process | The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. |
LARGE, UGCG, ST6GALNAC5 |
GO:0006689 | BP | ganglioside catabolic process | The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues. |
GM2A, NEU1 |
GO:0006690 | BP | icosanoid metabolic process | The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. |
PLA2G4A, PTGIS |
GO:0006691 | BP | leukotriene metabolic process | The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. |
TLR2, ALOX5, ALOX15, ABCC1, MAPKAPK2, PTGR1 |
GO:0006693 | BP | prostaglandin metabolic process | The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. |
PTGES, HPGD, PTGS2, AKR1C3, AKR1C2, PTGR1, ACOX1, PDPN |
GO:0006694 | BP | steroid biosynthetic process | The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. |
CYP17A1, CYP21A2, CYP19A1, HSD3B1, HSD17B1, PRLR, SRD5A1, HSD3B2, TSPO, SRD5A2, HSD17B2, FDFT1, PBX1, LSS, STAR, NR0B1, CYP51A1, HSD17B12, HSD17B11, HINT2, ACBD3 |
GO:0006695 | BP | cholesterol biosynthetic process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
INSIG1, TM7SF2, CYB5R3, APOA1, HMGCR, G6PD, CFTR, FDPS, FDFT1, LSS, MVD, PRKAA2, HSD17B7, HMGCS1, MVK, IDI1, SQLE, EBP, DHCR24, NSDHL, MSMO1, CYP51A1, APOA5, IDI2, DHCR7 |
GO:0006696 | BP | ergosterol biosynthetic process | The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. |
FDFT1, C14orf1 |
GO:0006699 | BP | bile acid biosynthetic process | The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. |
ACOT8, SLC27A2, CH25H, SCP2, STAR, HSD17B4, ACOX2, HSD3B7, CYP8B1 |
GO:0006700 | BP | C21-steroid hormone biosynthetic process | The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. |
CYP11A1, FDX1, AKR1B1, CYP11B1, CYP11B2, STAR, FDX1L |
GO:0006701 | BP | progesterone biosynthetic process | The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. |
FSHB, LHB, ADM, STARD3 |
GO:0006702 | BP | androgen biosynthetic process | The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. |
HSD17B6, CYP17A1, HSD3B1, SRD5A1, HSD3B2, SRD5A2, SCARB1 |
GO:0006703 | BP | estrogen biosynthetic process | The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. |
CYP19A1, HSD3B1, HSD17B1, STAR, HSD17B7, HSD17B12, HSD17B11 |
GO:0006704 | BP | glucocorticoid biosynthetic process | The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
CYP17A1, CYP11A1, CYP21A2, HSD3B1, CYP11B1, HSD3B2, HSD11B1, HSD11B2 |
GO:0006705 | BP | mineralocorticoid biosynthetic process | The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
CYP21A2, HSD3B1, CYP11B2, HSD3B2 |
GO:0006706 | BP | steroid catabolic process | The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
CYP3A4, STS, SRD5A2 |
GO:0006707 | BP | cholesterol catabolic process | The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
APOE, MT3, SCARF1, SCARB1 |
GO:0006710 | BP | androgen catabolic process | The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. |
HSD17B6, HSD17B11 |
GO:0006711 | BP | estrogen catabolic process | The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. |
UGT2B4 |
GO:0006713 | BP | glucocorticoid catabolic process | The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
YWHAH |
GO:0006725 | BP | cellular aromatic compound metabolic process | The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. |
SQLE, CYP1B1 |
GO:0006726 | BP | eye pigment biosynthetic process | The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. |
AP3D1, TYR |
GO:0006729 | BP | tetrahydrobiopterin biosynthetic process | The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. |
DHFR, QDPR |
GO:0006730 | BP | one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
CA12, AHCYL1, ALDH1L1, DHFR, CA2, CA3, MTHFD1, MTHFD2, CA4, AHCY, MAT2A, CA8, ALDH1L2, MTHFD1L, CA13, MTHFD2L, MAT2B |
GO:0006734 | BP | NADH metabolic process | The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
IDH3B, MDH1, MDH2, VCP, OGDH, MDH1B |
GO:0006738 | BP | nicotinamide riboside catabolic process | The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. |
PNP |
GO:0006739 | BP | NADP metabolic process | The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. |
G6PD, DCXR, FMO2 |
GO:0006740 | BP | NADPH regeneration | A metabolic process that generates a pool of NADPH by the reduction of NADP+. |
IDH1, G6PD |
GO:0006741 | BP | NADP biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH. |
NADK2 |
GO:0006743 | BP | ubiquinone metabolic process | The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. |
HMGCR |
GO:0006744 | BP | ubiquinone biosynthetic process | The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. |
PDSS1, PDSS2, COQ2, COQ3, COQ4 |
GO:0006749 | BP | glutathione metabolic process | The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. |
OPLAH, GSTA4, EEF1E1, GSTZ1, IDH1, ETHE1, GSR, GPX1, GSTA1, GSTP1, GSTM1, GSTT2, MGST1, G6PD, GSTM3, GSTM2, GSTT1, GSTO1, GSTM4, GLO1, GSTO2, GLRX2, GGT7, GSTK1 |
GO:0006750 | BP | glutathione biosynthetic process | The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. |
OPLAH, GCLC, GCLM, HAGH, CHAC2, MGST2, CHAC1, GGT7 |