| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0006412 | BP | translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
IGF2BP3, MRPS12, SLC25A17, MRPS14, SLC25A12, GATB, SLC25A14, EGFR, SLC25A5, RPLP1, RPLP2, RPLP0, RPS17, RPSA, HARS, SLC25A4, DARS, RPS2, SLC25A16, RPL35A, RPL7, RPL17, RPS4Y1, UCP1, RPL13, TARS, RPL10, RPL12, AKT1, RPL22, RPL4, RPL13A, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, RPL29, RPL34, DHPS, HARS2, SARS, RPL14, SLC25A1, UCP2, UCP3, RPS20, RPS3A, RPL26, RPL15, RPL27, RPL37A, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS25, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, RPL38, RPS21, MRPS5, MRPS36, MRPS21, RPL24, RPL36A, RPL19, SLC25A3, RPL18A, RPL18, EIF4EBP2, GTF2H2, MRPL23, CPEB4, MRPL51, SLC25A30, SLC25A26, RPS27L, CPEB2, MRPL55, MRPL52, MRPL41, GUF1, CPEB3, ABCF1, SLC25A43, GCN1, RPL36AL, SLC25A36, RPL39L, SLC25A44, MRPL34, SLC25A23, MRPL32, MRPL4, MRPL1, MRPL37, SLC25A39, SLC25A18, METTL17, SLC25A19, MRPS18A, SLC25A37, MRPL35, MRPL36, RRBP1, SLC25A10, SLC25A13, AGO2, MRPS2, RPL36, HBS1L, SLC25A15, MRPS18B, MRPL42 |
GO:0006413 | BP | translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
EIF4G3, EIF4E2, EIF1B, EIF5B, EIF3J, EIF2S1, RPLP1, RPLP2, RPLP0, EIF4E, RPS17, RPSA, RPS2, RPL35A, RPL7, RPL17, RPS4Y1, EIF4B, RPL13, RPL10, RPL12, RPL22, RPL4, RPL13A, EIF2S3, EIF1, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, EIF1AX, RPL29, RPL34, RPL14, EIF5, EIF3B, EIF6, EIF4A1, RPS20, ABCE1, RPS3A, RPL26, RPL15, RPL27, RPL37A, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS25, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, UBA52, RPL38, RPS21, RPL24, RPL36A, RPL19, RPL18A, RPL18, EIF2B5, EIF3A, EIF2B1, EIF4A2, LARP1, DHX29, EIF1AD, MTFMT, PAIP1, EIF2B3, EIF3K, EIF2B4, AGO2, RPL36 |
GO:0006414 | BP | translational elongation | The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. |
EEF1E1, RPLP1, RPLP2, EEF2, EEF1B2, EEF1D, TSFM, EEF1A1, EEF1A2, HBS1L |
GO:0006415 | BP | translational termination | The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). |
ABCE1, N6AMT1 |
GO:0006417 | BP | regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. |
MIF4GD, FOXO3, CDC123, TYMS, APP, S100A9, EIF4E, AKT1, AKT2, RGS2, MTPN, RPS14, RPL38, SARNP, RBM3, PUM3, PIWIL4, LSM14A, NGDN, GCN1, PTCD3, DNAJC1, RBM4B, LARP6, TACO1, MKNK1, MKNK2, EIF2B4, PA2G4, RBM8A, ZNF706 |
GO:0006418 | BP | tRNA aminoacylation for protein translation | The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. |
EEF1E1, FARS2, EPRS, HARS, DARS, TARS, HARS2, SARS, RARS, YARS, LARS2, KARS, PPA2, FARSA |
GO:0006420 | BP | arginyl-tRNA aminoacylation | The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
RARS |
GO:0006422 | BP | aspartyl-tRNA aminoacylation | The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
DARS |
GO:0006424 | BP | glutamyl-tRNA aminoacylation | The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. |
EPRS, EARS2 |
GO:0006427 | BP | histidyl-tRNA aminoacylation | The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
HARS, HARS2 |
GO:0006429 | BP | leucyl-tRNA aminoacylation | The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
LARS2 |
GO:0006430 | BP | lysyl-tRNA aminoacylation | The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
KARS |
GO:0006432 | BP | phenylalanyl-tRNA aminoacylation | The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
FARS2, FARSA |
GO:0006433 | BP | prolyl-tRNA aminoacylation | The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
EPRS, PARS2 |
GO:0006434 | BP | seryl-tRNA aminoacylation | The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
SARS |
GO:0006435 | BP | threonyl-tRNA aminoacylation | The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
TARS |
GO:0006437 | BP | tyrosyl-tRNA aminoacylation | The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
YARS |
GO:0006438 | BP | valyl-tRNA aminoacylation | The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
YARS |
GO:0006446 | BP | regulation of translational initiation | Any process that modulates the frequency, rate or extent of translational initiation. |
CTIF, EIF4G3, EIF1B, EIF5B, EIF3J, HSPB1, EIF4B, EIF1, EIF5, EIF3B, EIF4A1, NCBP1, EIF3A, EIF2B1, EIF4A2, EIF2AK4, EIF3K |
GO:0006449 | BP | regulation of translational termination | Any process that modulates the frequency, rate or extent of translational termination. |
HRSP12 |
GO:0006450 | BP | regulation of translational fidelity | Any process that modulates the ability of the translational apparatus to interpret the genetic code. |
GATC, RPS5, LARS2, DTD2 |
GO:0006452 | BP | translational frameshifting | A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. |
EIF5A, EIF5A2 |
GO:0006457 | BP | protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
CLGN, PFDN6, PPIH, DNAJB6, MPDU1, RP2, CLPX, BAG2, CRYAB, APCS, GNAI2, HSP90AB1, GNAI3, TXN, PDIA4, PRKCSH, GNB3, TCP1, ATF6, DNAJB2, CALR, CANX, ERP29, PDIA3, PPIF, NKTR, LRPAP1, DNAJA1, CCT6A, PPIC, CCT3, RANBP2, RGS7, CCT8, HSPE1, GNB1, GNB2, PPIA, GNAI1, CCT2, FKBP4, PPID, PPIL2, PDCL, PPIG, FKBP5, NFYC, MLEC, PDIA5, GANAB, PDIA6, CDC37, DNAJC21, TXNDC11, CWC27, QSOX2, ERO1B, PPIL4, NUDCD2, DNAJC19, ERO1A, DNAJC1, PFDN5, TTC1, DNAJC7, TXN2, CCT7, ERP44, TBCD, LMAN2L, TMX4, PDCL3, GRPEL1, DNAJC4, MKKS, PFDN4, SPHK1, DNAJB4, BAG5, PPIE, RUVBL2 |
GO:0006458 | BP | de novo' protein folding | The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. |
HSPD1 |
GO:0006461 | BP | protein complex assembly | The aggregation, arrangement and bonding together of a set of components to form a protein complex. |
WASL, KPNA3, TSPAN4, CLGN, MDM4, PPIH, NUPR1, LPXN, MITF, PEX14, GMNN, SKAP2, IKBKAP, FGA, CD74, TP53, CDK1, EPRS, LAMC1, SLC2A1, CCNB1, DARS, HMGA1, CAPN3, APC, FAS, MAPK3, PPP2R1A, PPP2R1B, OTX2, CAPG, SOX9, KNTC1, CAPZA1, SH3BGR, VAMP2, DLG4, SLC7A9, MDM2, APBA1, PPID, TRAF1, CHAF1A, CHAF1B, PICALM, HES1, TCEB2, VAMP3, OCLN, HFE, REPS2, DLG5, GEMIN5, PARD3, SLC7A6, CREBBP, KIFAP3, MAGI1, RANBP9, CARD10, SSBP3, NIFK, PARD6B, IL1RAP, MDN1, MPP6, PPARGC1A, SLC7A7, ZNF148 |
GO:0006463 | BP | steroid hormone receptor complex assembly | The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor. |
FKBP4 |
GO:0006464 | BP | cellular protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
WWP2, PLOD2, MAN2B1, ICMT, PLAT, CPE, CHRM3, LOX, AKT1, AKT2, USP6, GGCX, UBA7, ABL2, PHKA2, CDC34, SEPHS1, MMP15, RABGGTB, ADPRH, UBE2D3, UBE2M, UBA52, UBE2I, SLC35A1, PRKDC, PLOD1, ST3GAL1, PIGH, STK38, NEDD8, UBE2S, QPCT, ST3GAL2, TTLL9, ERO1B, FBXO22, TTL, ST8SIA4, BAP1, ERO1A, USP25, LCMT1, NAGPA, FBXL2, RIMKLB, PADI4, LIPT1, ST3GAL6, LOXL2, CSNK1G3 |
GO:0006465 | BP | signal peptide processing | The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. |
CLN5, F2, BGLAP, FURIN, GAS6, SPCS2, SPPL3, SPPL2A, HM13, PCSK5, SEC11C |
GO:0006468 | BP | protein phosphorylation | The process of introducing a phosphate group on to a protein. |
PIK3CD, PLK4, ADAM10, RIOK3, CASK, AURKA, DCLK1, FYB, SMAD9, BIRC5, IRAK2, MAP3K13, DAPK3, BUB1, NUAK1, CCNT1, BUB1B, CCNT2, JAK2, ROCK2, ULK1, ERN1, PRKRA, RPS6KA5, STK17B, IKBKAP, MAP4K4, LATS1, PDGFB, TGFB1, RAF1, ERBB2, NTRK1, APP, PRKCB, FYN, LYN, FGR, BCR, FGFR1, PSKH1, CDK4, BMP2, CCL2, CREB1, PRKCA, PRKACA, IGFBP3, ERCC2, NPR2, MAK, CDK11B, JAK1, ITPKA, MAPK3, PIK3R1, MAPK1, LTK, CDC25B, AKT1, ADRBK2, BMPR1A, ACVR1B, TGFBR1, TGFBR2, CSK, MAP3K8, PRKCI, PIK3CA, GRK6, SYK, MAPK8, MAPK9, PHKA2, PHKA1, CSNK1A1, CSNK1D, PIK3CG, MAPKAPK2, CDK8, CSNK1E, CLK2, GSK3B, CDK7, IRAK1, NEK2, NEK3, NEK4, JAK3, PLK1, DAPK1, LIMK2, PRKAG1, PRKAA2, SIK1, TGFB2, SRPK2, CCL8, CDK3, CDK6, CDK16, HSF1, GUCY2D, ACVR1, LIPE, PRKCD, RNASEL, DMPK, ST3GAL1, AKAP13, MERTK, ILF3, STK4, PAK2, PTK7, ILK, SQSTM1, PRPF4B, CAMK2D, RUNX3, GTF2H2, CAMK1, MORC3, FASTK, GAS6, PDK1, CDK10, PRKD1, STK38, RPS6KA1, MMD, MYLK, STK11, PKN1, PKN2, PDK4, DGUOK, AAK1, SBK1, PAN3, MLK4, CDC42BPA, MAST2, PNCK, AATK, NEK10, NEK8, CAMK1D, MAP4K3, TEX14, FAM20C, SCYL3, MINK1, STKLD1, PIK3C3, ANKK1, NEK11, NEK9, STK35, NEK7, GSG2, DYRK2, TBRG4, SGK3, ULK4, AURKB, RSRC1, PBK, MARK4, NEK1, ALPK1, PASK, TRIB3, TP53RK, SRPK1, PIK3R4, PKMYT1, MAP3K5, SMAD5, VRK1, MKNK1, CDK19, TRPM6, PINK1, WNK3, PRKD2, SIK2, TAOK3, HIPK2, WNK1, MKNK2, NEK6, LATS2, SNX15, NRBP2, BMP2K, ZAK, PLK2, MARK1, FNIP2, EIF2AK4, NLK, PRKAG3, TNIK, TLK1, CDK11A, AKT3, STK38L, SIK3, MAP4K5, CDC42BPB, IRAK3, STK24, XRCC6BP1 |
GO:0006469 | BP | negative regulation of protein kinase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. |
SOCS2, SOCS3, SOCS6, ITGB1BP1, SOCS1, FLRT2, GADD45B, LRP6, HSPB1, IL6, RB1, DCN, PTPRC, GSTP1, FABP4, BGN, GADD45A, AKT1, SFN, NF2, PPM1F, TSC2, GNAQ, PAK2, DNAJC3, ILK, PPP1R1A, SHB, RGN, PKN1, PODN, CAMK2N1, RTN4RL1, LRRTM4, CRIPAK, DEPTOR, UBASH3B, DUSP19, PPM1E, TRIB2, TRIB3, TRIB1, CHP1, DBNDD2, INPP5K, TAOK3, LRRC19, SMYD3, FLRT3, FLRT1 |
GO:0006470 | BP | protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
PP2D1, PPP6C, PLPP1, PLPP3, CTDSP2, PPP1R12A, CTDSPL, PPM1G, CDC14B, DUSP11, PPM1B, SBF1, CTDNEP1, PPP1R3D, PTPRC, BCL2, PTPRB, PTPRD, PTPRM, PTPN4, PPP2R1A, PPP1CC, PTPN9, TPTE, PTEN, PPP4C, PPP1CA, PPP1CB, PPP2CB, CYCS, DUSP2, PPP2R3A, PPP3CA, DLG1, MTM1, MTMR2, PPP2R5D, PTPRK, DLGAP5, TAB1, DUSP5, PTPN21, PTPRO, TIMM50, PPM1J, TNS2, PHLPP2, SSH2, PPP1R3B, PPM1K, PPTC7, UBLCP1, DUSP9, CPPED1, DUSP26, CTDSP1, PPA2, DUSP22, PHPT1, MTMR4, CTTNBP2NL, DUSP13, PPM1H, BTRC, PTPN22, DUSP10 |
GO:0006471 | BP | protein ADP-ribosylation | The transfer, from NAD, of ADP-ribose to protein amino acids. |
TNKS, PARP1, ARF4, SIRT2, TNKS2, PARP2 |
GO:0006473 | BP | protein acetylation | The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. |
NUPR1, EP300, FOXO1, CREBBP, KAT6A, KAT2B |
GO:0006474 | BP | N-terminal protein amino acid acetylation | The acetylation of the N-terminal amino acid of proteins. |
NAT9, NAA15, NAA50 |
GO:0006475 | BP | internal protein amino acid acetylation | The addition of an acetyl group to a non-terminal amino acid in a protein. |
PCK1, MDH2, EP300 |
GO:0006476 | BP | protein deacetylation | The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. |
HDAC3, HDAC1, SIRT2, HDAC6, HDAC5 |
GO:0006477 | BP | protein sulfation | The addition of a sulfate group as an ester to a protein amino acid. |
NDST1, CHST4, CHST5 |
GO:0006478 | BP | peptidyl-tyrosine sulfation | The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine. |
TPST1, TPST2 |
GO:0006479 | BP | protein methylation | The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. |
SNRPB, GSPT1, PCMT1, SNRPD3, BTG1, BTG2, METTL21A, PCMTD1, PRMT1, LCMT1, N6AMT1 |
GO:0006481 | BP | C-terminal protein methylation | The methylation of the C-terminal amino acid of a protein. |
ICMT, LCMT1 |
GO:0006482 | BP | protein demethylation | The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. |
KDM1A, PPME1 |
GO:0006486 | BP | protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
NPC1, PMM2, B3GALT2, B4GALT4, LARGE, B3GALT4, FUT1, FUT4, DDOST, PSEN1, DAD1, LRP2, GOLGA2, FUT2, TRIP11, EXT1, ALG10B, B3GNT9, GCNT2, ST8SIA4, EXT2, SDF2, B3GNT5, ALG9, B4GALT6, NAGPA |
GO:0006487 | BP | protein N-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. |
B4GALT1, FUT4, DDOST, MGAT2, ST3GAL1, MGAT5B, ALG8, FUT8, TMEM165, MAN1C1, ALG6 |
GO:0006488 | BP | dolichol-linked oligosaccharide biosynthetic process | The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. |
MPDU1, ALG10B, PQLC3, ALG8, ALG9, ALG13, ALG6 |
GO:0006489 | BP | dolichyl diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative. |
MVD |
GO:0006490 | BP | oligosaccharide-lipid intermediate biosynthetic process | The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. |
ALG8, ALG6 |
GO:0006491 | BP | N-glycan processing | The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. |
PRKCSH, MAN1A1, MAN2A2, ENGASE, ST8SIA4, EDEM1, FUT8, EDEM3, MAN1C1, MAN1B1, MGAT4A, MGAT4B |
GO:0006493 | BP | protein O-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. |
OGT, TRAK2, LARGE, VEGFB, ST8SIA6, GALNT2, GALNT1, DAG1, GALNT7, GALNT10, POMGNT2, TRAK1, POMT1 |
GO:0006497 | BP | protein lipidation | The covalent attachment of lipid groups to an amino acid in a protein. |
ABCA1, WIPI1, PIK3C3, ATG10, WDR45, WIPI2 |
GO:0006499 | BP | N-terminal protein myristoylation | The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein. |
PPM1B |
GO:0006501 | BP | C-terminal protein lipidation | The covalent attachment of a lipid group to the carboxy terminus of a protein. |
ATG12 |
GO:0006505 | BP | GPI anchor metabolic process | The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. |
PIGW, PGAP3 |
GO:0006506 | BP | GPI anchor biosynthetic process | The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. |
PIGA, PIGF, PIGH, PIGY, PIGG, PIGC, PGAP3, PIGU, CWH43, DPM3 |
GO:0006507 | BP | GPI anchor release | The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane. |
GPLD1 |
GO:0006508 | BP | proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
MASP2, TPP1, UBD, CAPN5, CFLAR, ADAM12, KLK10, DHH, NRDC, TBL1X, ADAM23, PDCD6, CAPN15, PRSS23, PAPLN, ECEL1, F8, F2, C1R, PLG, PLAU, PLAT, CFB, C3, C1QA, MMP1, CFI, KLK3, CTSD, PRSS1, CTSL, CTSB, CELA2A, CELA2B, MMP2, MME, MMP10, DLD, CTSH, C1S, C4A, C4B, MBL2, F5, BMP1, IDE, MMP9, KLK2, CAPN3, MMP8, MMP11, CTSS, MST1, DPP4, PSMB5, LAP3, PCSK1, TPP2, CASP1, PDIA3, SRI, PRSS3, DPP6, CTSK, PSMC4, PREP, CASP4, MMP14, MMP15, MMP16, THOP1, CTSC, CASP9, CASP6, NPEPPS, YBEY, ADAMTS20, SHFM1, ADAM8, OLR1, ADAM17, HTRA3, PMPCA, CBLB, PAPPA, BLMH, FGL2, WFDC2, ESPL1, CASP8, CUL7, CLCA4, PCOLCE, FCN2, NEDD8, LONRF1, LONRF2, MST1L, MMEL1, LONRF3, PREPL, PITRM1, CPZ, CTRB2, DESI1, RHBDD2, ERAP2, ADAMTSL4, THSD4, ASRGL1, ERMP1, TRABD2A, TMPRSS6, PM20D2, SFRP1, MPND, AOPEP, ADAMTS17, ADAMTS15, ADAMTS18, PIGK, HTRA1, GGH, TANK, NUDT16, STAMBPL1, CPB2, AGBL1, MMP19, TMEM59, NLN, NDEL1, ADAMTS10, CAPN10, ALG13, MMP25, NRIP3, MMP26, UFSP2, PGPEP1, C1RL, ADAMTS9, CTSZ, CTSF, ADAMTS1, USP25, LNPEP, GGT7, FBXL2, ADAM21, ADAMTS6, SUFU, ADAMTS5, ADAMTS8, AGTPBP1, RCE1, MYRF, MMP24, CPQ, XRCC6BP1, LOC440434 |
GO:0006509 | BP | membrane protein ectodomain proteolysis | The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). |
ADAM10, MYH9, RBMX, PSEN1, PSEN2, ADAM17, PRKCQ, ADAM9, DAG1, SPPL2A, APH1A, ADAM19, ERAP1 |
GO:0006511 | BP | ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
UBA6, USP27X, PSMD11, UBE2C, UBD, PSMD3, SIAH2, USP12, USP2, RNF8, USP1, UBR5, UCHL3, XBP1, USP6, PSMC2, RANBP1, UBE2A, USP11, UBE2E1, TTC3, ATXN3, UBE2D3, USP46, UBE2H, PSMC6, UBE2B, UBE2I, SQSTM1, CUL7, NEDD8, UBR3, USP34, USP31, USP51, USP45, USP48, SIAH1, TP53INP2, FBXO22, USP32, FBXO25, RFFL, BAP1, UFD1L, USP13, FBXO32, ITCH, USP28, PINK1, USP42, SMURF2, CYLD, FBXO8, RLIM, DTL, USP36, USP35, USP25, FBXL7, CDC23, AMFR, STUB1, USP22, RNF6, BTRC, USP20, USP15, ARIH1, NUB1, UCHL5 |
GO:0006513 | BP | protein monoubiquitination | Addition of a single ubiquitin group to a protein. |
PEX12, PARK2, UBE4B, UBE2D3, RBX1, UBE2B, CUL3, TRIM25, KLHL12, HUWE1, UBE2W, NEDD4L, RNF126, UBE2T, RAD18, DTL, FBXL2 |
GO:0006515 | BP | misfolded or incompletely synthesized protein catabolic process | The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. |
ATXN3, LONP2, UBE2W, OMA1, YME1L1, HDAC6, STUB1 |
GO:0006516 | BP | glycoprotein catabolic process | The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. |
MGEA5, STT3B, ADAMTS9 |
GO:0006517 | BP | protein deglycosylation | The removal of sugar residues from a glycosylated protein. |
MAN2B1, MGEA5, MAN2A2, ENGASE, MAN2B2 |
GO:0006518 | BP | peptide metabolic process | The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
MME, CPM, CPN1, THOP1, CPZ, AEBP1, MIPEP, NLN |
GO:0006520 | BP | cellular amino acid metabolic process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. |
QDPR, ATF4, SLC6A6, MTHFR, GLUD2, SLC7A2, SLC7A5, CLN3, SLC7A6, SCLY, SLC7A8, SLC7A7, SLC6A14, SLC25A15 |
GO:0006521 | BP | regulation of cellular amino acid metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. |
PSMD11, PSMD12, AZIN1, PSMD3, PSMD10, OAZ2, INS, ODC1, NQO1, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, OAZ1, PSME3, PSMC1, PSMC6, PSMD2, PSME4 |
GO:0006526 | BP | arginine biosynthetic process | The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. |
ASS1, CAD |
GO:0006527 | BP | arginine catabolic process | The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. |
DDAH1, DDAH2, FAH, NOS3 |
GO:0006529 | BP | asparagine biosynthetic process | The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. |
ASNS |
GO:0006531 | BP | aspartate metabolic process | The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. |
GOT2, ASS1, ADSS, ADSSL1 |
GO:0006532 | BP | aspartate biosynthetic process | The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. |
GOT2, BCAT1 |
GO:0006533 | BP | aspartate catabolic process | The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. |
GOT2 |
GO:0006534 | BP | cysteine metabolic process | The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. |
CTH, GCLC, GCLM, CDO1 |
GO:0006535 | BP | cysteine biosynthetic process from serine | The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. |
CBS |
GO:0006536 | BP | glutamate metabolic process | The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. |
GOT2, GCLC, GCLM, GLUD2, MTHFS, ALDH18A1 |
GO:0006537 | BP | glutamate biosynthetic process | The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. |
GLS, SLC1A3, GLUD2 |
GO:0006538 | BP | glutamate catabolic process | The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid. |
GLUD2 |
GO:0006541 | BP | glutamine metabolic process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. |
PFAS, PHGDH, ASNS, CTPS1, CAD, GMPS, GFPT1, ADSSL1, GGH, CTPS2 |
GO:0006543 | BP | glutamine catabolic process | The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid. |
GLS, PPAT |
GO:0006544 | BP | glycine metabolic process | The chemical reactions and pathways involving glycine, aminoethanoic acid. |
PHGDH, GART, SHMT1, DMGDH |
GO:0006545 | BP | glycine biosynthetic process | The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. |
DHFR |
GO:0006546 | BP | glycine catabolic process | The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. |
GCSH |
GO:0006548 | BP | histidine catabolic process | The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
HNMT |
GO:0006549 | BP | isoleucine metabolic process | The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. |
GHR, STAT5A, STAT5B |
GO:0006552 | BP | leucine catabolic process | The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid. |
HMGCL, AUH, MCCC1, MCCC2 |
GO:0006554 | BP | lysine catabolic process | The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. |
DLD, DLST, ALDH7A1, OGDH, PHYKPL, PIPOX, AASS |
GO:0006555 | BP | methionine metabolic process | The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. |
MTHFD1, MTHFR |
GO:0006556 | BP | S-adenosylmethionine biosynthetic process | The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. |
MAT2A, MAT2B |
GO:0006557 | BP | S-adenosylmethioninamine biosynthetic process | The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt. |
AMD1 |
GO:0006559 | BP | L-phenylalanine catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. |
GSTZ1, QDPR, FAH, ASRGL1, HGD |
GO:0006560 | BP | proline metabolic process | The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. |
PRODH |
GO:0006561 | BP | proline biosynthetic process | The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. |
ALDH18A1 |
GO:0006562 | BP | proline catabolic process | The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. |
PRODH |
GO:0006563 | BP | L-serine metabolic process | The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. |
SHMT1, CBS |
GO:0006564 | BP | L-serine biosynthetic process | The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. |
PHGDH, PSAT1 |
GO:0006565 | BP | L-serine catabolic process | The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. |
SHMT1, CBS |
GO:0006566 | BP | threonine metabolic process | The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. |
PHGDH |
GO:0006569 | BP | tryptophan catabolic process | The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. |
KMO, KYNU |
GO:0006572 | BP | tyrosine catabolic process | The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. |
GSTZ1, FAH, HGD |
GO:0006573 | BP | valine metabolic process | The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. |
GHR, STAT5A, STAT5B, ALDH6A1 |
GO:0006574 | BP | valine catabolic process | The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid. |
HIBADH, ALDH6A1, HIBCH |
GO:0006576 | BP | cellular biogenic amine metabolic process | The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. |
MAOA |