GO:0005815

CC

microtubule organizing center

An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

NUDT21, SPAG9, BUB1B, RAB11FIP3, TACC1, DAB1, FLOT1, TACC2, LATS1, NR3C1, KRT18, G6PD, PSKH1, ATF4, MAPK1, SLC1A4, PPP4C, CDC42, RPS7, RELB, PTK2, RAD51, LRMP, MLLT11, RBM39, CASP8, SLMAP, DLGAP5, RAB11B, CSPP1, FAM110C, KLHL12, LRIF1, ERCC6L2, FRY, PPP4R3A, CCDC141, CEP128, CENPU, HAUS6, RBBP6, PXK, HOOK3, C2CD5, MCPH1, KIF18A, FAM110B, NEK7, PDCD6IP, NUDCD2, SPDL1, IFT43, AJUBA, BOD1, SCYL1, MARK4, RPP25, KIFC1, UBXN6, TRIOBP, TAF1D, NEK6, LATS2, RASSF1, CLIC5, FNIP2, LRWD1, AKAP11, MTUS1, NDRG2, EXOC7, RUVBL1, TLN1, LAS1L, ARFGEF2

GO:0005816

CC

spindle pole body

The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.

MAP2K1

GO:0005819

CC

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

AURKA, MID1, BIRC5, PRC1, ZNF207, HAUS5, KIF20A, NR3C1, HSPB1, RB1, ERCC2, CDC27, AKT1, TTK, MYH9, CSNK1D, CENPF, ANXA11, KIF11, PLK1, TERF1, DYNLT1, CBX1, KIF23, MZT1, NSUN2, CDC20, MAP2K5, CBX3, SEPT6, NEDD9, SEPT2, RPS6KA2, MAPRE1, SEPT7, CSPP1, MAP7D1, CEP170, RIF1, MZT2A, PSRC1, MAEA, HAUS6, SIRT2, SHCBP1, GSG2, ARHGEF2, PTP4A1, TUBGCP3, AURKB, CHAMP1, HAUS7, VRK1, DIDO1, KIFC1, NUP85, NDEL1, HAUS4, ACOT13, CYLD, KIF15, FMN2, KLHL42, SPAST, FBXO5, MTUS1, TPX2, PRPF19, PIN4, INVS, FAM96B, SPIN1, MAD1L1

GO:0005826

CC

actomyosin contractile ring

A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis.

MYH9, MAEA, ANLN, MYH2

GO:0005827

CC

polar microtubule

Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart.

TUBG1, CUL3, TUBGCP3

GO:0005828

CC

kinetochore microtubule

Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.

KNTC1, RAB11A, KIF18A

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

UBA6, CNOT1, FABP12, WIPF3, UNC119B, WASH1, BBIP1, ACOT7, MYO1C, AIP, RHOD, LGALS8, PSMD11, PSMD12, ATOX1, DFFA, PIK3CD, DCTN6, WASL, EML1, IGF2BP3, PIK3C2A, PLK4, EXOC5, KPNA3, SDCBP, KPNA4, TRIM38, PPP6C, FBP2, UBE2C, ACACB, PDXK, SOCS2, DPYSL4, SOCS3, ARHGAP33, DYNC1I1, COPE, CCS, GOSR2, IRS4, ITGB1BP1, RIOK3, MAP2K7, PDCD5, CHEK1, NDC80, NRP1, OPLAH, BACH1, IRF6, TAX1BP3, CASK, AURKA, RAB29, PPP1R12A, AZIN1, XPO1, PIP5K1B, ARHGEF10, SYNJ2, PFAS, ANKRD28, SMAD7, FYB, KPNA5, ARPC2, ARPC3, POLR1C, PLSCR1, AXIN1, SMAD9, GSTA4, KMO, NPHP1, MAPK13, OGT, PMM2, POLR3G, INPP4B, MID1, HDAC3, BIRC5, GYG2, NUPL2, CFLAR, SOCS1, PHGDH, ARHGAP6, IRAK2, DYNC1LI2, PSMD3, SIAH2, MAP3K7, EEF1E1, RIPK2, RASA4, SYNJ1, EIF4G3, AKR7A2, BCL2L11, FOXO3, SMAD6, AKAP10, SPRY2, SPRY1, CHMP2A, PRC1, RGS10, BUB1, BUB3, GSTZ1, CYTH3, STX6, SGTA, SSNA1, NRDC, AHCYL1, PDE6D, RAD21, PPP1R12B, BNIP3L, PLIN1, PARK2, SPAG9, PIP5K1C, SNX3, MGEA5, SORBS3, GMDS, NMT2, BUB1B, EIF4E2, EXOC3, PDE8A, JAK2, PRMT3, UGDH, CTNND1, PFKFB2, EIF5B, DIAPH2, DNAJA2, NBN, NOL3, WDR1, ROCK2, ATG13, RAB11FIP3, CNOT3, DNAJB6, HMMR, ATP6V1G1, VPS4B, FLNB, ULK1, VPS26A, PSIP1, SRSF10, GMNN, CLN5, BANF1, DAB1, SKAP2, PRKRA, CRCP, LYPLA1, OFD1, PPM1B, PPP1R15A, EIF3J, PSMD10, TRAPPC6A, IDH1, STAM2, TNFSF13, ALDH1L1, RASSF9, PAK3, PDE5A, PDE9A, BEST1, SRP72, DDAH1, ALDH1A2, ATG12, PLEKHG5, MYO1D, SEC24D, FARP2, GLS, HAUS5, RHOBTB3, TRIM37, AP2A2, SEC31A, CEP152, FAM13A, UPP2, CCNB2, MFN2, OAZ2, ZWINT, KIF4A, PDE8B, TNKS, PGLS, PAPSS2, SMC2, PARN, PCNT, DUS4L, CNOT4, NFATC1, ATP6V1G2, BAG2, CRYZL1, AIFM1, LATS1, DDAH2, NUDT3, CH25H, PTTG1, BCL10, CCNE2, ADH1B, LDHA, ALDH1A1, DHFR, GSR, PNP, PGK1, AK1, ADA, CA2, ASS1, A2M, FOS, MYC, KRAS, IL1A, IL1B, CRYAB, LMNA, APOA1, APOA2, RBP4, GC, FTL, FTH1, MT2A, RAF1, ALDOA, APOB, TK1, TUBB4A, GAPDH, TP53, HSPB1, TYMS, GNAI2, APP, S100A8, ISG15, PCCA, EIF2S1, RPLP1, RPLP2, RPLP0, JUN, FABP3, PRKCB, UROD, FYN, CDK1, S100A9, S100A6, EIF4E, ENO1, GPI, NPM1, TPM3, SERPINE2, TH, LDHB, GPX1, ANXA2, CA3, PFN1, BPGM, APRT, EPRS, HSP90AA1, GALT, HNRNPC, LYN, TPM2, FH, NGFR, HSP90AB1, ASNS, GSTA1, VIM, RPS17, RPSA, ENO2, GSTP1, QDPR, RBP1, FBP1, GSTM1, TPM1, CLTA, HMOX1, CTSH, FGR, ALOX5, UCHL1, ALDOC, UBC, TRAPPC2, SULT1A3, HSPA1A, HSPA1B, GLI2, GLI3, RAP2A, CCL3, AR, BCL2, TXN, MAPT, PRKAR1A, CD28, HSPD1, THRA, CLU, IRF1, PNMT, SLC2A1, UMPS, PYGM, BCR, LAMP1, FGFR1, G6PD, PC, DMD, MTHFD1, CDK4, ODC1, HARS, CKB, ACTN1, MYL4, XRCC5, CFTR, EEF2, ALAD, LCP1, TNNT1, GYS1, PRKAR2A, ENO3, HSD17B1, FDPS, PKM, HSP90B1, CCNB1, MYL6B, SLC2A4, SNRPB, TYR, IDE, DARS, JUP, FABP4, AKR1B1, RAC2, GSPT1, EZR, FOSL1, HPGD, VAV1, NME1, NQO1, RPS2, CHN1, ALOX15, PFKFB1, CBR1, GNB3, PLCG2, FAH, STMN1, HSPA6, RHOQ, HMGA1, PRKCA, GJA1, SYN1, PRKACA, DES, AMD1, CTPS1, PFKL, PSMC3, TCP1, RPL35A, ARF4, RPL7, RPL17, PGAM1, MYL12A, HK1, POLR2E, TNNI3, SRM, NFKB1, NCF2, TYMP, RAB3B, RAB5A, PSMB1, CAPN3, CAST, RASA1, PDC, PTMS, GSTM3, ATP6V1B2, ATP6V1C1, FLNA, TNFAIP3, SAT1, COMT, TGM2, OSBP, PCMT1, RPS4Y1, GART, PAICS, UBA1, NME2, CALB2, TUBG1, JAK1, AHCY, EIF4B, ITPKA, DTYMK, RRM1, IL32, CHM, EEF1B2, MYL9, CDK2, APC, MPST, FAS, DNAJB1, DNAJB2, MT3, PSMA1, PSMA2, PSMA3, PSMA4, CTNNA2, RPL13, CHML, TARS, ZFP36, MAPK3, RPL10, DCK, CAD, CALR, PIK3R1, PSMB8, PSMB9, PSMB4, PSMB5, GSTM2, ABCD3, TMOD1, MAPK1, TPP2, IMPA1, CTGF, EPHB2, TKT, CASP1, NOS3, LMOD1, EEF1D, PRDX6, BLVRB, RPL12, CMPK1, PEBP1, PPP2R1A, CDC27, CCND2, CDC25A, CDC25B, CDC25C, ADSS, ADSL, CLIP1, SRI, GSTT1, CORO1A, GDI1, S100A7, MAT2A, PRKAR2B, RRM2, DNAJA1, AKT1, AKT2, YWHAB, SFN, PRDX2, GK, DCTD, GBP1, GBP2, CTH, MCM7, SHMT1, HSPA1L, HSPA4, CTNNA1, CTNNB1, RPL22, CBS, PCK1, IRS1, AGL, MYH9, ACTN2, DDIT3, MYH11, GLRX, CHKA, PSMC2, MAP2K2, RPL4, NUDT1, PGM1, PPP1CC, SREBF1, GMPR, GPX4, SRP14, TGFBR2, PPARG, TALDO1, SNCA, CDKN1A, CCT6A, NNMT, PSMB10, ADH7, RPL13A, STAT3, MDH1, EIF2S3, RGS2, UBA7, CSK, MAP3K8, PRKCI, ACTR1B, STAT5A, AKR1C3, ARHGAP25, PIK3CA, PIK3CB, EPS15, RPS27, ABL2, RPL35, CDKN2B, CDKN2C, HTT, MTHFR, SYK, NAMPT, PSMC4, MAPK8, MAPK9, PHKA2, PHKA1, RANGAP1, CRKL, NSF, CDKN1B, NOTCH1, IER3, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, MAP1B, GNPDA1, YAP1, IQGAP1, PLA2G4A, CAPZB, EIF1AX, ALDH1A3, RPL29, ZFP36L2, XDH, LIMS1, ARCN1, GCLC, GCLM, CD151, TRAPPC10, CSNK1A1, CSNK1D, IDH2, PIK3CG, MAPKAPK2, ALDH9A1, RPL34, FASN, DHPS, CCT3, ALDH7A1, INPP1, CENPA, CENPF, SRP9, UBE2A, PCYT1A, SARS, PPM1F, CSNK1E, STAR, PSMB3, FHIT, RANBP2, RGS3, RGS4, RGS7, TSC2, GSK3B, MTHFS, GMPS, MRE11A, HNMT, GDI2, SERPINB9, ERF, METAP2, KNTC1, PPT1, RPL14, CCT8, RAB7A, RAB9A, FABP6, PLCD1, DUSP3, BCAP31, TPMT, IRAK1, PSMD7, STAT5B, NEK2, UBE2E1, PGD, KPNA2, KPNA1, RAP1GDS1, JAK3, MAP2K6, ARHGDIA, ARHGDIB, STAT2, KIF11, HRSP12, CAPZA1, PLK1, ARFIP1, MVD, COPA, AP2S1, POLR2K, PLA2G16, IST1, RARS, ATXN3, CACNB3, OAZ1, YARS, PRKAG1, PRKAA2, BCAT1, EPHB4, EPHB1, GYS2, EMP2, EIF5, CSE1L, VCP, CASP9, CASP6, SEC13, NPEPPS, SH3BGR, EIF3B, BID, AP1S2, HDAC4, EIF6, PEX3, MAP3K7CL, GEMIN4, PCBP4, NUP107, SNX16, SESN2, MTPN, TIRAP, NLRP5, ARPC4, SEC61G, TPI1, PTEN, GABARAPL2, MYL6, ACTB, RAC3, EIF4A1, RPS20, SNAP25, PRPS1, CDC42, SRP54, UBE2D3, UBE2M, ACTR3, ACTR2, RAP2B, RPS3A, RPL26, PSME3, RPL15, RPL27, RPL37A, RHOA, NCALD, SEC61A1, STXBP1, COPZ1, RPL37, AP1S1, NUTF2, RPS7, PPP1CA, PPP1CB, CALM2, NCS1, PSMC1, RPS8, RPS15A, RPS16, YWHAE, RPS14, RPS18, RPS13, RPS11, SNRPF, LSM3, LSM6, SNRPD1, SNRPD2, SNRPD3, PSMC6, RPL7A, RAB11A, PPP2CB, ACTA2, RHOB, RPL23A, RPS6, RAB1A, RAP1A, RPS25, RPS26, GNB1, POLR2L, RBX1, GNB2, RPL30, RPL31, RPL10A, RPL32, RPL11, PPIA, RPL41, RPS27A, UBA52, GRB2, RAC1, AP2B1, VAMP2, YWHAZ, DYNLL1, RPL38, SKP1, RPS21, EIF5A, RACK1, ACTG1, ACTG2, UBE2I, TPM4, ACTC1, EEF1A1, TUBA4A, TUBB4B, PAFAH1B2, HBB, HBG1, HBA1, IGBP1, PIP4K2B, CCT2, CCNA1, GSTO1, PRKDC, BLOC1S1, BTG2, CRADD, NUCB2, TMF1, RPL24, RPL36A, SMAD3, ARF1, RPL19, SERF2, GNAS, SHC2, XIAP, FOXO4, CYCS, TFAM, CDK6, CDK5, HSF1, SORD, MYBPC1, IRF9, MDM2, PLIN5, SPTBN1, SET, RELB, AMPD3, MYL7, FABP5, ANK2, HMGCS1, SLC7A5, POU5F1, OCRL, MYL5, CENPE, KIF23, ID2, APBA1, RPL18A, MAP2K1, FKBP4, DST, GSTM4, CENPC, MVK, RELA, GBE1, TLE1, PRKCQ, GLO1, AKR1C1, REL, YWHAH, ICA1, PTK2, LIPE, ZBTB16, PRKCD, CALD1, RNASEL, PTPN11, PPAT, GFPT1, EXOSC9, AOX1, SULT2A1, PRDX1, RPL18, C1QBP, TJP1, ZFP36L1, KHDRBS1, BAX, MCL1, SOS1, SOS2, PPP3CA, CRYZ, PDE4C, PDE4D, DMPK, NCBP1, KCNA1, AHNAK, HSPA14, AP1B1, NUP160, SREBF2, FOXO1, AKAP13, CDC20, STX4, DPYD, HYAL2, TRIM26, ANK3, DLG1, RALGDS, ABR, TIAM1, ARHGAP5, STK4, TRAF1, CHAF1B, MTAP, EIF2B5, FADD, PRDX4, MAP2K5, MAPK7, PAK2, CBLB, PSMD2, DNAJC3, SELENBP1, MAD2L1, G3BP1, SKP2, GRB10, ITGB3BP, PPP2R5C, PDE3B, PDCL, UBE2V1, DYNC1I2, ORC1, ILK, XRCC4, UNC119, GOLGA4, MYO9B, NFATC2, GAB1, SMAD4, BIRC3, MTM1, SQSTM1, EIF4EBP1, RIPK1, HDAC1, CAMK2D, DCTN2, NAE1, ITPK1, IQGAP2, SNX1, MTMR1, MTMR2, CUL2, CUL3, CUL4B, FHL1, PMAIP1, BLMH, EXOSC2, RAPGEF1, IDI1, PDE7A, CUX1, CKAP5, HNRNPD, IL18, DAG1, EIF3A, ARHGEF7, DPYSL3, DCTN1, DYNC1H1, EIF2B1, EIF4A2, TRIM25, FLNC, GALE, PDE3A, CAPRIN1, GRB14, SLBP, NBR1, RASA3, KCNJ11, PUM1, ESPL1, SMC1A, RRP1B, LPIN1, PPP2R5D, COG2, CASP8, KIF22, NFATC4, KPNB1, PSME4, CUL7, ARHGAP19, NCAPH, NCAPD2, EXOSC7, ARL6IP1, KARS, KIF14, EEA1, NCF4, PAFAH1B3, PEA15, PRKD1, PCM1, PPP2R5B, PTGES3, QPRT, RASA2, RNPS1, ERBB4, RALBP1, ANKRD1, RPS6KA2, TCEB1, TCEB2, RHEB, DHCR24, RPS6KA1, SEC23A, SHB, STIL, RGN, TESK1, DIXDC1, TRADD, TSN, TRIP10, MAPRE1, ELAVL1, MYLK, TAB1, SMAD2, SMAD1, ITSN1, STK11, STXBP2, VAMP3, NEDD8, HSPB2, SEPT7, UAP1, PKN1, PKN2, MAPK14, CDC37, DPYSL2, FXN, NTRK2, FSCN1, HIF1A, IFI16, KYNU, GUK1, HAGH, DUSP6, DUSP7, UPP1, UGP2, DGUOK, ATP6V1F, PFKFB3, PFKFB4, CDO1, TXNRD1, LONRF1, PDS5A, ARHGAP31, ERCC6L, TSR1, HKDC1, LRRFIP1, TKFC, CCDC88A, COX19, PREPL, AMOT, MIDN, ARHGAP29, PDCD4, C11orf73, KLHL12, PYCRL, CDCA8, SGOL2, PAN3, ODF2, PDZD11, CMPK2, SGOL1, HERC4, WDR44, DOCK11, CEP78, HABP4, GNAS, WIPI1, EXOSC6, LDLRAP1, THEM4, BCL2L15, HECTD2, ARHGEF16, DENND4C, LRRC16A, FBXO31, CEP135, WWC2, XAF1, NADSYN1, JADE1, DENND5A, JMJD6, PTRF, ARHGAP11A, PPIP5K1, PSRC1, BORA, SHQ1, PAPD4, CPLX2, BLOC1S3, RICTOR, SARM1, AFTPH, RANBP10, DSTYK, RNF19B, PHLPP2, SYDE1, VPS13C, USP34, CENPU, TUBA1A, RHOU, ASRGL1, CENPQ, CYFIP1, RASGRP2, MON2, RNF144B, NPHP3, HAUS6, ARHGAP22, WAPL, NET1, SPRED1, SRGAP1, RBBP6, ARHGAP30, FGD2, RABEPK, PNPLA5, HUWE1, SDCCAG8, TTC7B, NOXA1, NT5DC3, AACS, ALYREF, IQGAP3, TAX1BP1, HOOK3, OSTM1, PKHD1L1, NLRC5, TRIM69, CARM1, CEP57, GPSM1, MIB1, DCP2, MINA, SIAH1, TRAPPC5, TPH2, UBR1, BBS7, WWC1, TP53INP2, SIRT2, MSRB3, FAM126B, AMOTL1, SRRM1, TRIM22, XRN1, ABI1, CENPL, TAGAP, ADSSL1, AHI1, CA13, ARHGEF28, ARHGAP24, APITD1, ARHGAP18, SFRP1, MINK1, TAB3, ARFGAP2, ENAH, HSD17B11, SPC24, SMG8, TNRC6A, ABCF1, PIK3C3, TRPV1, ATP6V1C2, DOCK8, NUP43, NUP37, ENGASE, BBS1, NUDT10, CMAS, CASC5, CEP70, KIF18A, TTC8, OSR1, GSDMB, TBC1D16, NT5C, DYNC2LI1, RHPN1, NEK9, TRPM4, RB1CC1, GEMIN5, FBF1, RAPGEF6, PARD3, ABHD5, PDCD6IP, FBLIM1, CHAC2, DEPDC1B, PHLDA1, BLNK, SNX33, SKA2, DNAJA4, GLMP, CYGB, ARAP3, EDARADD, GEMIN6, MYLIP, AHCTF1, RSPH1, TTN, ARAP2, RFFL, RAPGEF4, STARD8, GBF1, ELMO1, NDRG1, HSPH1, DOCK2, TBC1D5, NSMAF, AKAP1, TFG, USP6NL, HTRA1, STAM, GOLGA1, GGH, INPP5D, BCL2L2, TANK, KIFAP3, UFD1L, BAD, KHSRP, ARHGEF2, CUL5, TNFRSF25, HGD, RFK, ITFG2, PPP1R14A, TP53INP1, RERG, EXOC4, PNPLA2, PBXIP1, MIB2, EXOSC8, SKA1, SGK3, UPRT, MOAP1, HAUS1, OPTN, AP2M1, TUBGCP3, ANAPC16, SPDL1, HOOK2, SEH1L, MOCOS, MVB12A, CYFIP2, EDC3, PELI1, CDCA5, S100A16, DPH3, BICD1, PGM2, NUDT11, AURKB, CENPN, PDLIM5, DOCK6, SCLY, AJUBA, ZBED3, ABHD14B, NSL1, ITCH, SEC16B, DNAJC1, EXOC2, MARK4, PRMT6, CARD19, FGD4, PACRG, AK8, AGBL1, KCTD7, PRICKLE1, ANKRD27, ARAP1, IPO9, INPP4A, NEDD4L, SYNGAP1, FMNL2, SMG1, ALS2, GSDMA, DLC1, RAB3IP, VPS35, MCCC1, TRIB3, TP53RK, RANBP9, CEP89, NMNAT3, FAM129B, SEC62, STAC, PLIN2, NUP88, PIK3R4, TSC22D3, S100A13, DNAJC7, CDCA3, PKMYT1, CHP1, KIF2C, MAP3K5, MGLL, DOK1, MTR, SMAD5, CDC6, NPAS2, EPAS1, CCT7, HAUS7, PRMT1, DUSP9, SH3GL2, CITED1, VRK1, NCAPG, MAPKAP1, FERMT1, CORO1B, AIFM2, CENPK, INPP5K, POLR3GL, DCTN5, CENPO, DOHH, MKNK1, POLR3C, PDCD10, BDH2, CHAC1, ADI1, RNF126, MLST8, TRIM62, PHF20, DUSP23, NUP85, CDK19, SORBS1, BBS2, NPL, PINK1, IDI2, PACSIN1, HDAC8, POLDIP3, DUSP16, PARD6B, TRIM34, WNK3, PANK2, NUF2, ASPSCR1, OSBPL6, DPH1, TRIM8, UCK2, TRIM6, STRADB, NDEL1, MAP1LC3B, EIF5A2, UBA5, PAIP1, TOLLIP, RACGAP1, WWP1, AP5M1, GABARAPL1, ATG10, RBM38, ANAPC1, POLR3F, UPF3A, CDT1, SPTBN4, ALDH8A1, TNKS2, DPH5, DHX36, TXNIP, MUC13, CENPH, TPK1, DSN1, CHMP4B, MAP1LC3A, WNK1, RHOJ, EPB41L1, RGCC, GSTO2, HAUS4, EGLN3, DCTPP1, SYNC, PLEKHG2, PHAX, MOB1A, AKTIP, ECT2, ZWILCH, PSTPIP2, SEC61A2, LIN28A, UCK1, PELI2, PLEKHA5, SMURF2, UPF2, SCPEP1, RRAGC, AS3MT, SPC25, ETNK1, APOBEC3G, CENPJ, CAPN10, NEK6, MCCC2, TNRC6C, AGO4, TRIM39, SEPSECS, MYO10, PDE7B, ARFGAP3, VTA1, MID1IP1, PARD6A, EXOSC4, ISYNA1, MKKS, ACOT13, PLCB1, CYLD, RRAGD, PFDN4, EXOSC3, KIF13B, ACSS2, EIF2B3, ARHGEF4, ARHGEF3, PDGFC, EIF4ENIF1, SH2B1, CTPS2, PRTFDC1, LATS2, AASDHPPT, UBQLN4, INPP5E, SNX15, RAB6B, PHPT1, KIF15, HOMER3, SAMSN1, CENPM, DIAPH3, NRBP2, PDS5B, SMC4, ECHDC1, RNF146, ABHD10, TXLNG, NUDT15, RNF19A, EXOC1, PARVA, FGFR1OP2, RLIM, HAUS2, POLR3B, RNF216, UCKL1, GEMIN8, DDIT4, MKS1, PGPEP1, NDE1, SPHK1, MTMR4, ABI2, DACT1, FAM13B, BET1L, PLK2, GTSE1, ERAP1, FMN2, GLTP, IL37, RGL1, MAT2B, EHD3, AKAP7, ARHGAP23, ARHGAP20, CC2D2A, TBC1D14, ANKFY1, ATXN10, NFKBIL1, SAE1, NLK, PI4KB, HDAC6, VPS29, EIF3K, GRHPR, CTNNAL1, NXF1, ZMYM2, TJP2, DNAJB4, VTI1B, ADD3, PRKAG3, SEC63, KLHL3, TBK1, DDX20, BAIAP2L1, EVL, EIF2B4, ATP6V1H, LCMT1, SCOC, LNPEP, CNOT7, ERRFI1, CDC23, ANAPC5, ANAPC4, LSM7, CDC42EP3, NXT1, NUDT5, PCTP, FBXO5, AGO2, VAV3, MYH2, BAG5, BLOC1S6, MKLN1, WWC3, KIDINS220, ASAP1, CNOT6, NDRG4, TPX2, NOB1, PYCARD, PADI4, FZR1, ANAPC10, MYO6, NFU1, SUFU, NDRG2, G3BP2, ARHGAP26, STUB1, SNX6, ANGEL1, FAF1, NSFL1C, PLA2G4C, B9D1, PPP6R1, TNRC6B, SMG5, EXOC7, AGTPBP1, DICER1, SMC3, MAPK8IP1, SH2B3, GNE, POMP, CHKB, FARSA, BTRC, BTBD3, NISCH, PIKFYVE, DIS3, HIF3A, POLR1D, CRYL1, CARHSP1, GIT1, POLR3K, SUGT1, DERA, LSM2, CAB39, TPRKB, HDGFRP3, STARD13, RABGAP1, RPL36, C2CD2, WDR45, TLN1, KIF3A, DAAM1, FARP1, IRS2, MYO5A, WIPI2, ARIH1, LSM5, LSM4, RNF114, CEP83, YTHDF2, PAXBP1, UCHL5, ATP6V1D, N6AMT1, TRAPPC1, RBM8A, SNX5, PSAT1, COPG1, SAR1B, ARFGEF2, MAD1L1, STK24, SNCAIP, IGF2BP2, SESN1, WASF2

GO:0005832

CC

chaperonin-containing T-complex

A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.

TCP1, CCT6A, CCT3, CCT8, CCT2, CCT7

GO:0005833

CC

hemoglobin complex

An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.

CYB5R3, HBB, HBG1, HBA1

GO:0005834

CC

heterotrimeric G-protein complex

Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein.

GNG7, GNAI2, GNAI3, RGS7, GNG4, GNG11, GNB1, GNAI1, GNG5, GNA12

GO:0005838

CC

proteasome regulatory particle

A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.

PSMD12, PSMD10, PSMD7, PSMD2

GO:0005839

CC

proteasome core complex

A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.

PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMB10, PSMB3

GO:0005840

CC

ribosome

An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.

PRMT3, EIF2S1, RPS17, MT3, CANX, SNCA, RPS27, RPS9, RPS10, RPL15, RPL27, RPS7, RPS18, RPS13, RPS11, RPS25, UBA52, MRPS25, MRPS10, MRPS34, RPL36A, HSPA14, DNAJC21, MRPL54, MRPL14, MRPL50, ABCF1, GCN1, MRPL38, METTL17, MRPL44, RRBP1

GO:0005844

CC

polysome

A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.

EIF2S1, RPS4Y1, EIF4B, PSMA1, CALR, FUS, FXR1, RPS6, FMR1, NAA30, GCN1, MSI2, UNK, EIF2AK4, IMPACT, AGO2, DRG1

GO:0005845

CC

mRNA cap binding complex

Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.

EIF4E2, EIF4E, FMR1, NCBP1, CYFIP1, AGO2

GO:0005846

CC

nuclear cap binding complex

A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.

NCBP1

GO:0005847

CC

mRNA cleavage and polyadenylation specificity factor complex

A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.

CSNK1A1, CPSF1, FIP1L1, ZC3H3, SSU72, CPSF2

GO:0005849

CC

mRNA cleavage factor complex

Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.

NUDT21

GO:0005850

CC

eukaryotic translation initiation factor 2 complex

Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.

EIF2S1

GO:0005851

CC

eukaryotic translation initiation factor 2B complex

A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.

EIF2S1, EIF2B5, EIF2B1, EIF2B3, EIF2B4

GO:0005852

CC

eukaryotic translation initiation factor 3 complex

A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.

DDX3X, EIF3J, EIF3B, ABCE1, EIF3A, EIF3K

GO:0005853

CC

eukaryotic translation elongation factor 1 complex

A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.

EEF1B2, EEF1D, EEF1A1, EEF1A2

GO:0005856

CC

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

FRMD3, PDLIM1, HIP1, SDCBP, TOR1A, ENC1, ITGB1BP1, RAB29, SYNJ2, NPHP1, TGFB1I1, RIPK2, SPRY2, PDE6D, LZTS3, PPL, MPZL2, SORBS3, JAK2, LDB3, HSBP1, ARL6IP5, FARP2, PNP, KRT1, HSPB1, S100A8, S100A9, TPM3, TUBB, PFN1, VIM, KRT16, TPM1, FGR, ALDOC, DMD, JUP, KITLG, JAK1, STOM, MAPK3, MAPK1, PTPN4, NOS3, NF2, ACTN2, LRPPRC, CAPZB, CCT3, HINT1, CNN1, JAK3, MAP2K6, ARHGDIA, ARHGDIB, CAPZA1, SMTN, GYS2, EPPK1, ACTB, RHOA, ACTG1, TPM4, TUBB4B, CDK5, ANK2, PTK2, CALD1, NEXN, MYO1E, CALCOCO2, SNTA1, SHROOM2, SNTB1, COTL1, DAG1, CTTN, FLNC, CASP8, FRMPD4, DHCR24, TRADD, TRIP10, TRIP11, TRIP6, CCDC6, SGCB, FSCN1, PTPN21, LRRFIP1, PREPL, WIPI1, TBCEL, FNBP1L, ARHGAP21, KAZN, TWF2, SLC30A9, DNMBP, FGD6, RAPH1, SSH2, MAEA, FGD2, NEK8, NOSTRIN, ABI1, ARHGAP24, ENAH, JMY, BICD2, SSH3, RNF128, PARD3, SHROOM3, ARAP3, TRIB2, DOCK2, SGCD, SYMPK, INPP5D, ARHGEF2, BICD1, TCTN2, SGCZ, FRMD6, KLHL5, RAB3IP, FNBP1, PKP4, DNAJC7, MARVELD1, OSBPL10, PINK1, UACA, TRIM9, KLHL4, ACTR6, EPB41L4B, DEF6, EPB41L1, PSTPIP2, TNS1, EPB41L4A, SPAG4, CASS4, GPHN, CDC42SE2, CDC42SE1, PARVA, ABI2, DNAH9, PLEK2, MARK1, CC2D2A, FRMD4A, UXT, CTNNAL1, ADD3, KLHL3, DDX20, EVL, DNAI1, TNIK, TAOK2, PLEKHH1, ARHGAP26, MACF1, SLC7A11, EPB41L3, FRMD4B, FARP1, FAM65B, CDC42BPB, IGF2BP2, PCLO

GO:0005858

CC

axonemal dynein complex

A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.

DNALI1, DYNC2LI1, DNAH1

GO:0005859

CC

muscle myosin complex

A filament of myosin found in a muscle cell of any type.

MYL6B, MYL9, MYH11, MYL5, TTN, MYH2, MYH4

GO:0005861

CC

troponin complex

A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.

TNNT1, TNNI3

GO:0005862

CC

muscle thin filament tropomyosin

A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments.

TPM3, TPM2, TPM1, TPM4

GO:0005865

CC

striated muscle thin filament

Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.

TMOD1, LMOD1

GO:0005868

CC

cytoplasmic dynein complex

Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.

DYNC1I1, DYNC1LI2, BCL2L11, SNX4, TPR, DYNLL1, DYNLT1, DYNC1I2, DYNC1H1

GO:0005869

CC

dynactin complex

A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.

DCTN6, ACTR1B, DCTN2, DCTN1

GO:0005871

CC

kinesin complex

Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.

KIF1C, KIF5C, KIF1B, KIF20A, KIF4A, KIF11, YWHAE, CENPE, KIF23, KIF22, KIF14, KLC3, KIF18B, KIF18A, KIF20B, KIF2C, KIFC1, NDEL1, KIF13B, NDE1, STARD9

GO:0005873

CC

plus-end kinesin complex

Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule.

LOH12CR1, KIF15

GO:0005874

CC

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

EML1, KRIT1, DYNC1I1, MID1, BIRC5, DYNC1LI2, SYNJ1, SPRY2, ZNF207, KIF1C, KIF5C, KIF1B, TPPP, HAUS5, WDR47, KIF20A, PCNT, EML2, TTLL1, DNAL4, TUBB4A, TUBB, MAPT, MAP2, STMN1, TCP1, MT3, CLIP1, MAP2K2, CCT6A, LRPPRC, MAP1B, IQGAP1, CCT3, EMD, CCT8, NEK2, KIF11, DYNLL1, TUBA1B, TUBA4A, TUBB4B, IGBP1, CCT2, MAP1A, CENPE, KIF23, FKBP4, GOLGA2, CAMSAP2, DNAH14, DLG1, TIAM1, MTA1, DYNC1I2, SNTB2, TUBB3, DCTN2, TUBA3C, SHROOM2, TUBB2A, EIF3A, DCTN1, DYNC1H1, MAP7, KIF22, KIF14, MAPRE1, DPYSL2, CSPP1, FAM110C, TTLL9, ODF2, CEP170, CAMSAP1, REEP3, KLC3, SARM1, DNAH12, TUBA1A, HAUS6, HOOK3, RASSF3, GAS2L3, CEP57, LRRC49, DNAH10, CCDC50, SIRT2, NAV1, MDM1, NEK7, DNAH5, SHROOM3, RASSF5, NDRG1, HSPH1, APPBP2, FGF13, ARHGEF2, TEKT1, PBXIP1, HAUS1, RMDN1, DNAH11, HOOK2, RMDN2, KIF20B, FEZ1, CCT7, HAUS7, TBCD, TUBB6, KATNB1, TUBB2B, KIFC1, KATNAL1, NDEL1, MAP1LC3B, RACGAP1, GABARAPL1, MAP1LC3A, TUBB1, HAUS4, EML4, CENPJ, NEK6, MID1IP1, KIF13B, RASSF1, KIF15, TCP11L1, STAU2, SYBU, NDE1, DNAH9, CAMSAP3, DNAH1, HDAC6, SPAST, DNAI1, TEKT2, TUBE1, TUBD1, MTUS1, TPX2, MACF1, INVS, FAM179B

GO:0005875

CC

microtubule associated complex

Any multimeric complex connected to a microtubule.

EML1, MID1, KIF1B, STAU1, EML2, MAPT, MAP2, MAP1B, RANBP2, MAP1A, MAP7, PEA15, APPBP2, RANBP9, DNAAF2, HDAC6, CLIP2, RABGAP1

GO:0005876

CC

spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

AURKA, HDAC3, PRC1, TBL1X, NCOR1, KIF4A, CDK1, CDC27, CSNK1D, KIF11, PLK1, CALM2, PSRC1, SKA3, SKA2, KIFAP3, SKA1, AURKB, SPAG5, NUSAP1, TBL1XR1, HAUS2, KIF3A

GO:0005879

CC

axonemal microtubule

A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.

ARFGEF2

GO:0005881

CC

cytoplasmic microtubule

Any microtubule in the cytoplasm of a cell.

AXIN1, MID1, BCL10, SAA1, CYP2A6, TUBG1, APC, CLIP1, DYNLT1, TUBA1B, MAPRE1, TUBA1A, DCXR, HID1, DYNC2LI1, CKAP2, BICD1, GRAMD3, KIF2C, VIMP, ENKD1, TRPV4, CYLD, GTSE1, HDAC6, CLIP2, SRPRB

GO:0005882

CC

intermediate filament

A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.

KRT18, KRT8, VIM, KRT19, KRT7, KRT16, KRT3, JUP, NME1, DSP, GJA1, DES, NME2, CLIP1, KRT9, SLC1A4, NES, DST, KRT17, IFFO1, MNS1, MICAL1, PKP2, KRT23, PNN, SYNC, MYO5A

GO:0005883

CC

neurofilament

A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter.

NRP1, NEFH, LDLRAP1

GO:0005884

CC

actin filament

A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.

WIPF3, ARHGAP6, DAPK3, WDR1, COBL, FYN, ACTN1, LCP1, RAC2, EZR, RHOQ, TMOD1, LMOD1, CORO1A, ACTN2, IQGAP1, CAPZB, RAC1, ACTC1, TEK, AKAP13, MYO9B, CTTN, PLS1, AMOT, PALLD, PAWR, AIF1L, CORO1B, MYO5A

GO:0005885

CC

Arp2/3 protein complex

A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.

ARPC2, ARPC3, ARPC4, ACTR3, ACTR2

GO:0005886

CC

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TBC1D3D, TBC1D3E, KIAA0922, TBC1D3F, MYO1G, MYO1C, SNAP23, FXYD1, AIP, KCNK1, TLR4, RHOD, APBB1, GRM8, CLIC1, TNFRSF11B, PIK3CD, WASL, PIK3C2A, BTN3A3, KRIT1, CHL1, SDCBP, CLDN4, PLPP1, PLPP3, ARHGAP33, KCNK3, IRS4, ADAM10, ITGB1BP1, NRP1, TNFSF11, TNFRSF10C, TSPAN4, TAX1BP3, PCDH17, RGS12, CASK, RAB29, SYNJ2, SMAD7, FYB, ANGPT2, PLSCR1, ZNF185, SLC22A1, FANCG, OGT, GRM6, GPR37, HDAC3, NCAM2, STX7, SLC16A3, SLC31A1, ABCC4, ABCC5, RGS5, ASAP2, FLRT2, ADAM12, IRAK2, SPINT2, AQP9, MAP3K7, DHH, RASA4, MGAM, CACNA1G, ATP8B1, CA12, AKAP10, SPRY2, SPRY1, PRC1, RGS10, ITM2A, CYTH3, STX6, SSNA1, C21orf2, TYROBP, PPP1R12B, GNG7, ADCY3, TRAK2, FZD6, PPL, NRP2, PLXNC1, ADCY9, NMT2, TLR5, TLR2, SLC16A7, LPXN, CTNND1, SLC19A2, RAMP1, RAMP3, FCGR3B, PLXNA2, SDC3, ADAM23, FZD7, AOC2, ATP9A, ROCK2, MFAP3L, COBL, PHACTR2, LRP5, SEMA7A, HMMR, ATP6V1G1, ENTPD6, ENTPD3, FLNB, TULP3, GPR32, TECTA, LGR5, GPC4, TNFRSF21, STX11, SKAP2, CRCP, ITGA10, LRP6, ADAP1, RP2, SLC22A3, GABBR2, PAK3, ARL6IP5, FLOT1, SLC22A5, BEST1, SRP72, DXO, STK17B, AQP8, SLIT2, PLEKHG5, LRIG2, ERLIN2, DKK1, ABCA8, SLCO2B1, AP2A2, UNC5C, SNX4, ABCA1, VNN1, SLC2A10, STAMBP, DIRAS3, SNAP29, STAU1, RECK, BCL10, DNAL4, ACTL6A, F8, GOT2, EGFR, AK1, F2, PLG, PLAU, CFB, ADA, CA2, SERPINC1, C3, KNG1, NRAS, KRAS, LDLR, TGFA, TGFB1, PENK, GCG, IGF2, TNF, CD4, HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, APOA1, APOE, FGA, FGB, FGG, GYPA, AMBP, TFRC, ESR1, RAF1, ANXA1, APOB, PRNP, CD74, KRT1, GAPDH, ERBB2, NTRK1, HSPB1, CYBB, GNAI2, SLC4A2, GYPC, IGF1, ATP1B1, APP, ITGB3, ITGB2, S100A8, SERPINE1, ALPL, ICAM1, ITGB1, PRKCB, INSR, FYN, S100A9, ENO1, GPI, ITGAV, LPL, CSF1R, ANXA2, ADRB2, HSP90AA1, LYN, IGF1R, NGFR, CHRM2, CD55, SLC3A2, MMP2, MME, CD14, PTPRC, MET, ADRB1, ITGA5, VIM, KRT19, GNAI3, STS, RPSA, IL6R, ENO2, GSTP1, CD48, HMGB1, CLTA, ANXA4, CNP, WNT2, PDGFRB, FGR, LCT, UCHL1, FURIN, C4A, C4B, TBC1D3H, UBC, RAP2A, AR, RRAS, PTPRF, MAPT, TFPI, KIT, CD28, HSPD1, GHR, HSPA5, SLC2A1, SLC2A3, ITGAM, RALA, RALB, LAMP1, FGFR1, PSKH1, F5, FCGR1A, FCGR2A, ANXA3, ACTN1, ACE, XRCC5, IFITM1, GP1BB, TDGF1, LAMP2, CFTR, NCAM1, EEF2, HLA-E, HLA-DRB4, LCP1, PRKAR2A, ENO3, ADRB3, SELL, CD99, CPM, DRD2, PLA2G2A, PKM, HSP90B1, SLC2A4, IDE, IL1R1, JUP, ETS2, PVR, RAC2, IFNGR1, B4GALT1, ACPP, EZR, FOLR1, VAV1, CD46, CD1D, DSP, ALOX15, CD44, ITGB4, PDGFRA, PECAM1, EPCAM, PRLR, GNB3, SELE, CD36, CPE, IL7R, PLCG2, RHOQ, IFNAR1, PRKCA, ITGA2, GJA1, NPR3, GAP43, HLA-G, PTPN2, CR1, LGALS3, ITGB5, ADRA2B, IL1RN, SDC1, PAM, CDH2, CD58, VCAM1, CD53, ATP2B1, HLA-DPA1, CD33, CHRM3, TNFRSF1B, RAB3B, RAB5A, TRH, NPR2, ITGAX, CAPN3, EFNA1, MAG, ATP6V1B2, ATP6V1C1, FLNA, S1PR1, FPR1, CNR1, SYT1, KITLG, NT5E, C5AR1, ZP3, FGFR2, ERBB3, SDHB, CD9, COMT, ENPP1, SLC2A5, CA4, LHCGR, MRC1, ITGA6, ANOS1, PTPRD, TNFSF4, ATP2B4, FSHR, CXCR2, APC, FPR2, ADRA1D, EDNRA, PTAFR, F2R, AZGP1, FAS, MT3, NPY1R, ITGA3, ITGB8, KLRC1, CD27, ACVR2A, DPP4, IL1R2, PIK3R1, SSFA2, HTR2C, ADORA2B, CTGF, EPHA3, EPHB2, LTK, NOS3, CD40LG, MARCKS, CNGA1, GNA11, BLVRB, CCND3, MIP, HLA-A, HLA-F, AVPR2, ADSS, SLC6A1, CHRNA5, LRPAP1, ADORA1, AGTR1, OXTR, SSTR1, GNRHR, CORO1A, PRKAR2B, SDC4, SLC6A6, GABRA5, AKT1, AKT2, FCGR2B, CCKBR, MC4R, GPR183, GBP1, STX2, ACSL1, CDH5, LSP1, ABCC1, SDC2, CD68, GRK5, HTR7, GPC1, BTC, USP6, CTNNA1, CTNNB1, PHB, NF2, RDX, SSTR5, ADRA1A, HRH1, ADRA1B, PTGER4, IRS1, MYH9, ACTN2, BSG, ADRBK2, FLT4, GJC1, CHRNA7, NUDT1, BMPR1A, ACVR1B, TGFBR1, LTBR, SCNN1A, TGFBR2, SNCA, BRCA1, IFNGR2, SPAM1, ITGAE, FEN1, PLA2G5, IL6ST, STAT3, MDH2, PMEL, OPRL1, ETV5, AQP2, CD200, RGS2, WNT5A, CSK, SLC19A1, ADCYAP1R1, HTR2B, PRKCI, PIK3CA, PIK3CB, EPS15, DPP6, IL12RB1, LIFR, SLC1A3, SLC1A2, SLC1A4, GDF5, PTGFR, PTGER3, PTGER2, MCAM, GRK6, SYK, KIR3DL2, PHKA2, PHKA1, NSF, NOTCH1, MAP1B, IQGAP1, OR3A3, SLC6A8, MTNR1A, ATP5O, GRIA4, LIMS1, GLIPR1, NPBWR1, GLRB, LEPR, CD151, IFNAR2, SLC1A6, CSNK1D, PIK3CG, CD97, TRPC1, NPY2R, PTH2R, SLC11A1, SLC11A2, MTNR1B, FASN, CCT3, PCYT1A, ARL4D, TMED10, NUMB, PSEN1, HINT1, RGS3, RGS4, RGS7, PSEN2, GSK3B, SEPHS1, AGTR2, GNAQ, GNG4, MMP14, SLC26A2, METAP2, KNTC1, LRBA, RNF144A, BCAM, ATP1A2, RAB5C, RAB9A, RAB28, SCNN1G, PLCD1, MMP15, MMP16, IRAK1, CAV2, CLCN3, CLCNKA, CLCNKB, PLXNA3, VAMP7, ADCY7, SLC7A2, STAT2, MSH6, EFNA4, EFNB2, EFNA5, DAPK1, SUCLG1, RABGGTB, AP2S1, CACNB3, CACNA2D1, ATP12A, ATP1B3, EPHA5, EPHB4, EPHB1, EPHA4, GAS1, EMP1, EMP2, EMP3, EIF5, SLC12A2, RRAD, MFAP3, F2RL1, CDH6, CDH11, CDH12, CDH13, CDH15, NPEPPS, TMEM50B, WNT3, PRSS12, HSD17B7, JAM2, ANTXR2, TIRAP, FXYD4, CD81, PLP1, PTEN, PPP4C, ACTB, RAC3, ZP1, SNAP25, CDC42, RAB4B, RAB5B, CXCR4, UBE2D3, RAP2B, RHOA, STXBP1, B2M, GNG11, RRAS2, TSPAN5, PPP1CA, CALM2, NCS1, RAB11A, RHOB, RAP1A, GNB1, GNB2, RPS27A, UBA52, GRB2, RAC1, AP2B1, VAMP2, GNAI1, UBE2B, DYNLL1, GNG5, ACTG1, PAFAH1B2, CXADR, SIRPA, ADAM8, DLG4, PIP4K2B, OLR1, BTN3A2, JAG1, ADAM17, HLA-DRB3, NUCB2, SLC7A9, SMAD3, ARF1, ARF5, GNAS, SHC2, DAB2, VLDLR, HSPG2, PKD1, LRP2, HDLBP, CDK5, CDK16, MDM2, CD83, IL5RA, PMP22, ANK2, HMGCS1, IFITM3, IL1RL1, SLC7A5, MC2R, XPC, EWSR1, OCRL, ROR1, SP3, DSC2, MAP2K1, TEK, GNA12, CAV1, PLAUR, NOTCH2, PRKCQ, CD164, YWHAH, PTK2, ZBTB16, PRKCD, CALD1, SLC18A2, APLP2, C1QBP, TJP1, POLE, SOS1, TNK2, PCDH1, IL10RB, DDR1, SLC20A2, CD47, DMPK, KCNA1, AHNAK, FCHO2, SMAGP, APOBR, BST2, ARHGEF5, KCNMA1, ASPH, KCNH2, RAB40B, STX4, CNTN1, CDH17, MERTK, GRIN2A, HYAL2, PTPRJ, ANK3, DLG1, PTP4A2, ABR, TIAM1, MALL, STRN3, BAMBI, FADD, PAK2, CBLB, PTGDR, STX3, G3BP1, CLN3, GRB10, IFIT5, SLC14A1, PPIL2, ORC1, ILK, SLC39A6, LSAMP, NFATC2, IL18R1, TCIRG1, GPM6B, MTM1, TRPC3, SERINC3, CAMK2D, PKD2, NAE1, TDG, DGKZ, SEMA5A, MTMR1, PTCH1, FHL1, ACVR2B, SHROOM2, ITGA9, ENPP2, BMPR2, KLF9, CACNA1C, CEACAM7, KCNC3, RAB33A, DAG1, DSG2, ARHGEF7, SCARF1, EIF2B1, SELPLG, CTTN, FLNC, GPR176, GRB14, KCNJ12, FAT1, ITPR2, ITPR3, INPP5A, ITPR1, KCNJ11, KANK1, MELK, RFTN1, GRM3, GPNMB, CLCA4, MORF4L2, JOSD1, SLC39A14, KARS, KIF14, ACOX1, PDIA6, PLCL1, PRKD1, NECTIN1, ERBB4, ANGPT1, MTFR1, P2RY14, TLR1, SHB, TGFBI, TRADD, TRIP6, SLC1A5, NPY5R, MSMO1, ITSN1, STXBP2, VAMP3, CACNA1E, RAB11B, ZYX, SEPT7, ADRM1, UAP1, SLC15A2, PKN1, PKN2, ASIC2, OCLN, DBN1, PTPRO, CYP51A1, AOC3, DUOXA1, MICB, MICA, PDS5A, ERCC6L, RALGAPA2, SLC4A8, HLA-DRB5, HFE, LRRFIP1, CHD9, PIGY, CCDC88A, ANO6, NKAIN1, ATP13A5, RFTN2, CYBRD1, SDK2, TMEM97, IGSF11, BCORL1, ALG10B, RALGPS1, TJAP1, GNAS, DGKK, COLEC12, MUC21, FNBP1L, THEM4, ABCC10, STXBP5, GPR158, WLS, COL13A1, ANKRD20A1, CROCC, GPR157, RIF1, NKAIN2, CHIC1, DENND4C, LRRC16A, ZDHHC20, TNS2, TMEM198, STEAP4, LAIR1, LAMTOR1, JADE1, OR52E8, TBC1D3C, STYK1, RGS7BP, TENM4, MFSD5, RGMB, JMJD6, MAST2, ERAP2, SLC27A4, SLC39A4, LRRC8B, SLC27A1, PPIP5K1, TMEM65, CNST, ADGRD1, AGTRAP, ANKRD11, PARM1, C6orf89, OLFM4, SEZ6L2, LRIG3, GLDN, BNC2, SLCO4C1, QSOX2, RAPH1, PREX2, SV2A, RHOU, SV2B, RAB11FIP2, ARC, RASGRP2, SLC16A14, SLC16A9, PLPPR4, SLC36A1, DCXR, SDK1, NET1, SPRED1, RABEPK, PXK, PHLDB2, GPR126, ZBTB33, TTC7B, MAGI2, SLC51A, CD163, SERINC5, P2RY8, SGMS1, SLC26A11, RASSF3, CHD1L, TRIM69, RALGPS2, LSR, DGKH, TMEM219, FRAS1, COL23A1, PDPN, GPSM1, C2CD5, MIB1, TMPRSS6, CRLF3, SIAH1, RELL1, PLEKHH2, NOSTRIN, VSTM4, SERPINA12, SLC44A2, ITPRIP, LRRC8A, SLC30A8, SULF2, SULF1, CNTN4, SIRT2, KLHL7, PALM2, FAM126B, TMEFF1, ANKRD13A, KIAA0319L, KMT2E, XRN1, UNC5B, CPAMD8, TBC1D3, NLGN4X, SPG20, GPC2, CRIPAK, ARHGEF28, LYPD1, ABHD12, NLGN1, MUC15, MPP5, SFRP1, SLC44A3, ARHGEF39, AFAP1L2, TAB3, ARRDC1, ARFGAP2, AOPEP, CD177, NIPA2, ENAH, MFSD2A, PCSK9, SERBP1, DAGLB, SLC44A5, ARRDC4, LRRC16B, RGS22, BVES, PLPP5, TRPV1, FLCN, NUP35, GPRC5A, DNER, STXBP6, SEMA6D, TSPAN14, OR5A2, OR5L2, OR14C36, SVIP, LILRB1, SGMS2, TPCN2, INADL, PCDH19, KCNG3, CYP2W1, GSDMB, SPATA20, SLC35G2, ENOX1, KIAA1524, MARCH1, SPPL3, SPPL2A, HM13, MRAP, BICD2, TRPM4, DLG5, KCNV2, LRRC8C, SYTL5, FAT3, IGDCC4, RAPGEF6, PARD3, PAQR8, SH3TC2, ATP8B4, SLC16A10, SCARB1, FRS2, RAB2B, CEMIP, SLC20A1, SLC38A5, BLNK, SECTM1, APH1B, SLC44A1, ARAP3, IPCEF1, STAB2, SLC5A11, LIPH, PALLD, GPR98, CLEC4D, CACNG8, DNAJC9, MYLIP, RFFL, RAPGEF4, CLEC2B, AQP3, PIEZO1, SLC7A6, ELMO1, SLC9A6, NDRG1, SGCD, FCGR1B, RYR2, USP6NL, HTRA1, SYMPK, DIO2, NRCAM, INPP5D, GHSR, GLG1, SLC5A5, FGF13, RAB8B, SLCO2A1, RIT1, TNFRSF25, ATP6V0A1, LPP, MR1, KISS1R, PMEPA1, ADIPOR1, EXOC4, PNPLA2, TTC17, ARRDC3, SLC22A18, APH1A, SYTL4, GPR146, TLCD1, AP2M1, RASD2, REPS1, RAB39B, C11orf24, CDCA5, SLC47A1, CPNE2, S100A16, PERP, MRAP2, VMP1, SLC41A3, AJUBA, PAWR, ITCH, SLC41A2, DNAJC1, FAM84B, EXOC2, FCRL1, APOLD1, KCTD7, FRMD6, C8orf37, PTCHD1, SLC46A1, ANKRD27, CLIC6, ARAP1, ERMAP, NEDD4L, PLIN4, GSDMA, TRPM7, MAGI1, OR2A5, PANX2, PANX1, FNBP1, TRIB3, RANBP9, RASL10B, MYADM, SRPK1, CEP89, KCNK17, FAM129B, CSF3R, HBEGF, S1PR3, NEU1, GPER1, PLIN2, MPHOSPH8, MPHOSPH9, PKP4, P2RX4, OSMR, CHP1, MGLL, FEZ1, HSD17B10, LITAF, MGST2, SLC29A1, CIB1, HAUS7, PRRT1, PKP2, SH3GL2, MAPKAP1, VIMP, TMEM47, HEPH, CORO1B, CPPED1, SDF4, ESYT1, MARVELD1, INPP5K, UPK3B, SYT11, NDC1, PDCD10, ABHD6, ADI1, KATNB1, TAPBPL, SORBS1, JAM3, TRPM6, LGR4, CLEC7A, TMEM59, CACNG6, SLC46A2, PACSIN1, HDAC8, CADM1, PARD6B, NLN, PCDH11Y, ASPSCR1, OSBPL6, GPR63, PRKD2, ULBP3, FAM129A, CD244, SIGLEC1, TRIM4, INO80B, SLC39A8, WWP1, CCDC8, SDCBP2, CYSTM1, TRPV6, UPF3A, WNT5B, ABCG8, EHD4, SPTBN4, OR51E2, CXCL16, SLC26A1, TSPYL2, SLC38A1, TAOK3, RAB3GAP2, PNN, RHBG, TTYH1, SEMA4A, PIGU, RHOJ, DEF6, EPB41L1, FNDC4, GAREM1, DOCK5, C10orf54, AKTIP, HN1L, LIN7B, SLC28A3, SMURF2, PLEKHA2, NTN4, TRPV4, IFT122, VEZT, ETNK1, LGR6, PCDH9, SLC24A3, CAPN10, GBA2, SYTL2, MAGEE1, ANKH, PCDH18, GPAM, TMEM8A, SRA1, GOPC, RANGRF, MYO10, CD209, ABCB6, SLC40A1, TNFRSF12A, TREM1, MMP25, PARD6A, ACKR4, NRN1, CD320, ADAP2, IL1RAP, CD93, SLC52A3, ANO2, RTN4, NECTIN3, GPHN, CD163L1, DLL4, PDGFC, DUOX2, DUOX1, IL17RB, PLSCR4, CDC42SE2, INPP5E, CDC42SE1, SERINC1, AGPAT3, RASSF1, KCNIP2, GPR27, TNFRSF19, TM7SF3, HOMER3, LMBRD1, LIN7C, TDP1, EXOC1, PARVA, PAG1, PAK1IP1, PAQR5, STAB1, VNN3, SPHK1, CELSR3, ERAP1, FMN2, FAM120A, GDE1, GPRC5B, FLRT3, FLRT1, CRIM1, MPP6, VAPA, MARK1, CNTN3, STIM2, FNIP2, PCDH10, ATXN10, CTSZ, GABBR1, CTNNAL1, SLC9A2, TJP2, DNAJB4, KL, ADD3, EPHA6, SLC23A2, TES, SLC2A6, LIMA1, ASIC3, PCYOX1, SLC7A8, BAIAP2L1, ATP6V1H, SLCO3A1, ZDHHC2, LNPEP, PLXNA1, KCNG1, GPR160, CDH22, ENPP5, LAMP5, CDC42EP3, ADAM21, ACSL6, VAV3, ITGA11, PRND, RAB22A, NRXN1, RAB23, MTUS1, FZD4, SLC7A7, MYO6, COL17A1, PCDHGC3, PCDHA12, SLC6A14, RPH3AL, STUB1, PROCR, NSFL1C, FLVCR2, MACF1, EXOC7, SLC7A11, THSD7A, ERVW-1, LAMP3, TRPC6, COLQ, AKT3, KCNK6, RASD1, TNFSF13B, SIGLEC7, ITM2B, ATP11B, NISCH, EPB41L3, STXBP5L, SLC27A6, CRYL1, SAMHD1, PKP3, L3MBTL1, TLN1, TCAF1, DAAM1, PLXND1, IRS2, GPSM3, PCDHB9, PCDHB14, PCDHA9, PCDHA13, PCDHA1, HRH3, TRPV2, CDC42BPB, SNX9, LYVE1, HCFC2, F11R, GPC6, WNT6, MRPL42, XRCC6BP1, SLC30A1, TNFRSF11A, SLC4A4, ENPP4, LOC440434

GO:0005887

CC

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

ESYT2, SLC22A23, TMEM150B, TMEM150C, FXYD1, KCNK1, TLR4, GRM8, TNFRSF11B, SLC33A1, CLDN4, PLPP1, PLPP3, ENPP3, KCNK3, PRRG1, TNFSF11, TNFRSF10C, TSPAN4, EREG, PLXNB2, DCLK1, NPC1, MUSK, PLSCR1, SLC22A1, GRM6, GPR37, SLC16A6, SLC16A3, SLC31A1, SLC31A2, ABCC5, TLR3, CLDN3, FLRT2, AQP9, ATP8B1, TSPAN6, TYROBP, HS6ST1, ADCY3, FZD6, LY75, GPR137B, PLXNC1, ADCY9, TLR5, TLR2, TSPAN2, SLC16A7, SLC19A2, RAMP1, RAMP3, PLXNA2, ADAM23, GPR32, LGR5, GPC4, TNFRSF21, SLC22A3, CEACAM4, GABBR2, TM7SF2, SLC22A5, BEST1, AQP8, SLCO2B1, CSPG5, SLC25A14, MPZL1, ABCA1, SLC2A10, ECEL1, CLDN1, TSPAN13, TSPAN12, FADS2, CLPTM1, LDLR, TGFA, TNF, HLA-DRA, HLA-DQA2, HLA-DQA1, TFRC, OPN1SW, NTRK1, CYBB, SLC4A2, GYPC, APP, ITGB3, SLC25A5, ICAM1, INSR, ITGAV, CSF1R, ADRB2, IGF1R, NGFR, CHRM2, CD55, MME, PTPRC, MET, MFI2, ADRB1, CD48, LCT, PTPRF, CD28, GHR, SLC2A1, SLC2A3, CHRNB1, LAMP1, FGFR1, IGF2R, SLC25A4, GP1BB, ADRB3, SELL, CD99, DRD2, SLC2A4, IL1R1, PVR, IFNGR1, FOLR1, CD46, CD1D, MUC1, CD44, PDGFRA, EPCAM, ATP2A2, CD36, TMEM11, IFNAR1, GJA1, NPR3, CR1, ADRA2B, SDC1, TSPAN8, EPOR, CD58, CD53, FUT1, ATP2B1, HLA-DPA1, CD33, CHRM3, TNFRSF1B, NPR2, EFNA1, MAL, FPR1, CNR1, C5AR1, FGFR2, ERBB3, CD9, ENPP1, SLC2A5, LHCGR, MRC1, PTPRB, PTPRD, PTPRG, TNFSF4, ATP2B4, FSHR, IL4R, CXCR2, FPR2, ADRA1D, EDNRA, PTAFR, F2R, FAS, NPY1R, KLRC1, CD27, ACVR2A, STOM, HTR2C, PTPRM, TNFRSF8, ADORA2B, EPHA3, EPHB2, LTK, CD40LG, CNGA1, CD6, MIP, TM4SF1, AVPR2, SLC6A1, ADORA1, AGTR1, OXTR, SSTR1, GNRHR, SDC4, SLC6A6, GABRA5, CCKBR, GPR183, ABCC1, EVI2B, HTR7, GPC1, PHB, SSTR5, ADRA1A, HRH1, ADRA1B, PTGER4, TIE1, BSG, FLT4, GJA5, ACVR1B, LTBR, SCNN1A, IFNGR2, PMEL, OPRL1, AQP2, CD200, SLC19A1, ADCYAP1R1, HTR2B, TSPAN7, LIFR, SLC1A4, PTGFR, PTGER3, PTGER2, KIR3DL2, SLC6A8, MTNR1A, NPBWR1, GLRB, CD151, IFNAR2, SLC1A6, CD97, TRPC1, NPY2R, PTH2R, SLC11A1, SLC11A2, MTNR1B, PSEN1, PSEN2, AGTR2, MMP14, SLC26A2, TNFSF10, BCAM, SCNN1G, MMP15, MMP16, BCAP31, CAV2, CLCN4, CLCN5, CLCNKA, CLCNKB, PLXNA3, HNRNPM, SLC7A2, EFNA4, EFNB2, EPHA5, EPHB4, EPHB1, EPHA4, SLC12A2, F2RL1, JAM2, FXYD4, CD81, TSPAN5, VAMP2, CXADR, ADAM8, OLR1, SLC35A1, JAG1, ADAM17, HLA-DRB3, SLC7A9, PKD1, ATP2C1, MPP1, SLC25A3, IL9R, CD83, SLC7A5, MC2R, ROR1, NRG1, TEK, GUCY2D, CAV1, TGFBR3, PLAUR, NOTCH2, ACVR1, CD164, SLC18A2, TYRO3, PCDH1, DDR1, SLC20A2, CD47, KCNA1, SMAGP, BST2, MERTK, GRIN2A, LRMP, PTPRJ, TSPAN31, PTGDR, PTK7, SLC14A1, SLC39A6, TCIRG1, TRPC3, PKD2, LAPTM5, ACVR2B, ALCAM, ENPP2, BMPR2, SELPLG, ADGRE1, GPR176, CAPRIN1, KCNJ12, FAT1, ITPR3, KCNJ11, SSPN, GRM3, GPNMB, SLMAP, CLCA4, SLC39A14, EBP, PRKD1, NECTIN1, PTPRK, P2RY14, TLR1, MMD, SLC1A5, NPY5R, SCN9A, ZYX, ADRM1, SLC15A2, ASIC2, LY6E, SGCB, NKG7, NTRK2, AMHR2, PTPRO, MICA, SLC4A8, HFE, ATP13A5, FAM26F, STEAP4, TENM4, SLC18B1, SLC39A4, CSPG4, KIAA1324, SLCO4C1, SLC16A12, BTN2A1, MAEA, PLPPR4, TMEM150A, SLCO6A1, KTN1, TRABD2A, CD163, SGMS1, SLC26A11, PDPN, APCDD1, NLGN4X, BEST3, NLGN1, MFSD2A, GOLM1, PLPP5, TRPV1, GPRC5A, SEMA6D, TSPAN14, SGMS2, SLC35G2, LRRC8C, SLC16A10, SCARB1, FRS2, SLC20A1, SLC38A5, APH1B, STAB2, SLC5A11, CLEC2B, AQP3, SLC7A6, SORL1, HAS2, NRCAM, HPS1, SLC5A5, SLCO2A1, TNFRSF25, KISS1R, APH1A, PERP, PLPPR2, VSIG2, DCBLD2, HHIP, TSPAN18, KCNK17, CSF3R, HBEGF, MUC4, S1PR3, GPER1, P2RX4, SIGMAR1, TM9SF2, SLC29A1, SYT11, TM2D1, LGR4, C1QTNF1, CADM1, SLC39A8, PCDHAC1, TRPV6, OPN3, SLC26A1, SEMA6A, SLC38A1, RHBG, TMEM245, SEMA6B, ATP13A3, CALHM2, ADGRL3, SLC28A3, KCNK12, TRPV4, PLGRKT, LGR6, SLC24A3, ANKH, TMEM8A, SLC40A1, ACKR4, IL1RAP, ATP13A2, SLC52A3, GPRC5C, NECTIN3, IL17RB, PAG1, STAB1, FLRT3, FLRT1, TENM3, GABBR1, KL, EPHA6, SLC23A2, SLC2A6, ASIC3, SLC7A8, SLCO3A1, ZDHHC2, LNPEP, PLXNA1, SLC25A13, NAGPA, PILRB, PILRA, NRXN1, SLC39A10, FZD4, SLC7A7, COL17A1, PCDHA7, PCDHA6, PCDHA4, SLC6A14, PROCR, TFR2, GPR34, SLC7A11, TRPC6, RCE1, SIGLEC7, CNPY2, PLXND1, PCDHB3, PCDHA8, PCDHA5, PCDHA3, PCDHA2, PCDHA11, PCDHA10, PCDHA1, PCDHAC2, HRH3, MMP24, TRPV2, LYVE1, GPC6, ADGRG1, HS3ST3B1, TNFRSF11A, SLC4A4

GO:0005889

CC

hydrogen:potassium-exchanging ATPase complex

A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present.

GM2A, ATP12A

GO:0005890

CC

sodium:potassium-exchanging ATPase complex

Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.

FXYD1, ATP1B1, ATP1A2, ATP1B3

GO:0005891

CC

voltage-gated calcium channel complex

A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.

CACNA1G, CACNB3, CACNA2D1, PDE4D, CACNA1C, CACNA1E, CACNG8, CACNG6

GO:0005892

CC

acetylcholine-gated channel complex

A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.

CHRNB1, CHRNA5, CHRNA7, STXBP5

GO:0005895

CC

interleukin-5 receptor complex

A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3.

SDCBP

GO:0005896

CC

interleukin-6 receptor complex

A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130.

IL6, IL6R, IL6ST

GO:0005899

CC

insulin receptor complex

A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.

INSR, IRS1, SORBS1

GO:0005900

CC

oncostatin-M receptor complex

A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta.

IL6ST, OSMR

GO:0005901

CC

caveola

A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.

JAK2, LRP6, FLOT1, ATP1B1, INSR, HMOX1, SLC2A1, SELE, ATP2B4, F2R, MAPK3, MAPK1, NOS3, PTGS2, IRS1, BMPR1A, TGFBR2, ADCYAP1R1, ATP1A2, CAV2, EFNA5, ATP1B3, CDH13, CDH15, CAV1, LIPE, KCNMA1, AKAP6, CLN3, PTCH1, BMPR2, PTGIS, PTRF, SPRED1, BVES, KIF18A, SCARB1, PRKCDBP, DLC1, RANGRF, HDAC6

GO:0005902

CC

microvillus

Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.

MYO1G, MYO1C, CA2, TGFB1, PDGFA, CNP, EZR, VCAM1, ATP6V1B2, OXTR, RDX, CRB1, TEK, HYAL2, IQGAP2, ANGPT1, FSCN1, AOC3, SLC27A4, DCXR, CD302, EXOC4, BBS2, KIF13B, FMN2, MYO6

GO:0005903

CC

brush border

The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

MYO1C, CLIC1, ACTN4, FLNB, DAB1, MYO1D, MME, ACTN1, EZR, MYH9, MYL6, ACTR3, EPS8, MYO1E, RALGDS, ITPR3, PLS1, DCXR, CDHR2, ADD3, LIMA1

GO:0005905

CC

clathrin-coated pit

A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.

LDLR, TFRC, TF, APP, HSPD1, SLC2A4, SELE, EPS15, AP1S2, AP1S1, DAB2, VLDLR, LRP2, OCRL, TNK2, FCHO2, PICALM, CTTN, ITSN1, AAK1, LRP10, CEMIP, REPS1, FNBP1, SH3BP4, MYO6, AP4S1

GO:0005911

CC

cell-cell junction

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

SNAP23, KRIT1, CASK, PDZD2, NPHP1, FLRT2, ACTN4, CTNND1, WDR1, FLOT1, PLEKHG5, APP, KRT8, ANXA2, ITGA5, KIT, SLC2A1, ACTN1, JUP, VAV1, CDH2, CD53, FLNA, PIK3R1, PTPRM, CORO1A, AKT1, CDH5, CTNNA1, CTNNB1, MAP2K2, CSK, LIMS1, CDC42, ACTR3, PPP1CA, GRB2, CXADR, ADAM17, TEK, PRKCD, PCDH1, TWF1, PTPRJ, DLG1, MYO1E, TIAM1, STX3, PTK7, ILK, PKD2, BMPR2, DSG2, FAT1, PRKD1, PTPRK, OCLN, FSCN1, PDZD11, COL13A1, CDC42BPA, SV2A, SDCCAG8, IQGAP3, AHI1, PARD3, FRS2, AQP3, AJUBA, MAGI1, MYADM, PKP4, CDCA3, PKP2, TMEM47, CADM1, PNN, C10orf54, ECT2, LIN7B, ADGRL3, PDLIM7, LIN7C, FLRT3, FLRT1, ADD3, LIMD1, MYH2, HEG1, FZD4, COL17A1, PIKFYVE, EPB41L3, PKP3, TLN1, CDC42BPB, F11R

GO:0005912

CC

adherens junction

A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.

SDCBP, PLPP3, NPHP1, CTNNA2, CDH5, CTNNB1, NF2, NOTCH1, EFNA5, CXADR, JAG1, TNK2, MYO1E, NECTIN1, PTPRK, PIANP, AHI1, SHROOM3, AJUBA, MAGI1, FAM129B, PKP2, TMEM47, TBCD, WNK3, SPTBN4, TRPV4, VEZT, LIMD1

GO:0005913

CC

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

ESYT2, PDLIM1, CLIC1, SDCBP, NOP56, DDX3X, CCS, SMAD7, PPL, EXOC3, CTNND1, FLNB, IDH1, FLOT1, RSL1D1, CCNB2, VAPB, LYPLA2, LDHA, EGFR, ALDOA, ANXA1, ITGB1, KRT18, ENO1, ANXA2, PFN1, LYN, SLC3A2, HSP90AB1, HSPA1A, HSPA1B, HSPA5, EEF2, PKM, JUP, PVR, EZR, RPS2, CDH2, CAST, FLNA, PCMT1, PAICS, ITGA6, APC, DNAJB1, S100P, CTNNA2, PTPRM, EEF1D, PRDX6, OXTR, YWHAB, SFN, S100A11, CTNNA1, CTNNB1, RDX, MYH9, BSG, TAGLN2, CAPG, EIF2S3, CD200, TMPO, TMPO, EPS15, RANBP1, RANGAP1, CRKL, IQGAP1, CAPZB, RPL29, CSNK1D, RPL34, FASN, NUMB, MRE11A, EMD, RPL14, CCT8, CAPZA1, ARFIP1, IST1, RARS, EIF5, RPL15, YWHAE, RPL7A, RPL23A, RAB1A, RPS26, YWHAZ, RACK1, HIST1H3D, RPL24, HDLBP, SPTBN1, DSC2, CALD1, PRDX1, TJP1, GOLGA2, AHNAK, SMAGP, TWF1, DLG1, PAK2, PICALM, SNX1, SHROOM2, CKAP5, DAG1, CTTN, TRIM25, SEPT2, STK38, NECTIN1, PCBP1, CNN3, MAPRE1, RAB11B, ZYX, SEPT7, PKN2, DBN1, FSCN1, LRRFIP1, COBLL1, FNBP1L, ARHGEF16, TWF2, LARP1, MPRIP, GIGYF2, BZW1, DHX29, PHLDB2, KTN1, ERC1, ABI1, ARHGAP18, SERBP1, GPRC5A, STXBP6, KIAA1524, DLG5, ZC3H15, PPP1R13L, ATXN2L, H1FX, NDRG1, GCN1, EFHD2, PDLIM5, SCYL1, FMNL2, FAM129B, PKP2, CORO1B, SORBS1, CADM1, EHD4, CHMP4B, EPB41L1, RTN4, NECTIN3, ANLN, DIAPH3, PARVA, ARGLU1, VAPA, TJP2, TES, LIMA1, BAIAP2L1, PUF60, ASAP1, MKL2, MYO6, MACF1, RUVBL1, SSX2IP, SH3GLB1, PKP3, TLN1, PPME1, SNX9, SNX5, F11R, STK24, BZW2, WASF2

GO:0005915

CC

zonula adherens

A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.

CTNND1, JUP, CTNNA1, SORBS1, CAMSAP3

GO:0005916

CC

fascia adherens

A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.

ACTN1, JUP, DSP, GJA1, DES, CDH2, CTNNB1

GO:0005921

CC

gap junction

A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.

GJA1, CALB2, MIP, GJA5, GJC1, TJP1, DBN1, PANX2, PANX1

GO:0005922

CC

connexin complex

An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.

GJA1, GJA5, GJC1

GO:0005923

CC

bicellular tight junction

An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.

CCDC85C, CLDN4, NPHP1, CLDN3, CLDN1, CDK4, EPCAM, APC, CDH5, CTNNB1, TGFBR1, ADCYAP1R1, PRKCI, JAM2, RAP2B, CXADR, PMP22, TJP1, ANK3, DLG1, SHROOM2, OCLN, AMOT, TJAP1, NHS, MTDH, MAGI2, AMOTL1, MPP5, BVES, INADL, PARD3, SYMPK, ARHGEF2, MARVELD3, MAGI1, TBCD, JAM3, PARD6B, WNK3, EPB41L4B, ECT2, LIN7B, PARD6A, ASH1L, LIN7C, VAPA, FRMD4A, TJP2, F11R

GO:0005924

CC

cell-substrate adherens junction

An adherens junction which connects a cell to the extracellular matrix.

SORBS1

GO:0005925

CC

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

PDLIM1, SNAP23, SDCBP, ADAM10, NRP1, TSPAN4, CASK, PPP1R12A, ARPC2, ARPC3, ZNF185, CAPN5, FLRT2, TGFB1I1, ACTN4, PIP5K1C, SORBS3, LPXN, FLNB, FLOT1, SORBS2, MPZL1, EGFR, PLAU, KRAS, ANXA1, HSPB1, SLC4A2, ITGB3, ICAM1, RPLP1, RPLP2, RPLP0, ITGB1, NPM1, ITGAV, P4HB, PFN1, ANXA6, MME, PTPRC, ITGA5, VIM, RPS17, ANXA5, PDGFRB, HSPA1A, HSPA1B, RRAS, HSPA5, RALA, IGF2R, ACTN1, LCP1, PRKAR2A, CD99, HSP90B1, JUP, PVR, RAC2, EZR, CD46, RPS2, CD44, HMGA1, ITGA2, GJA1, ITGB5, RPL7, SDC1, CDH2, CSRP1, FLNA, CD9, TGM2, ITGA6, PPIB, JAK1, CFL1, TNC, ITGA3, MAPK3, DPP4, CALR, MAPK1, LAP3, MARCKS, RPL12, PDIA3, CCND3, S100A7, SDC4, YWHAB, GRK5, CTNNA1, CTNNB1, RDX, RPL22, MYH9, ACTN2, BSG, MAP2K2, RPL4, PPP1CC, RPL13A, MCAM, RPL5, RPS9, RPS5, RPS10, IQGAP1, LIMS1, CD151, CD97, NUMB, MMP14, GDI2, CAV2, CNN1, EFNB2, CDH13, CD81, ACTB, CDC42, ACTR3, ACTR2, RPS3A, RPL27, RPL37A, RHOA, B2M, RRAS2, RPS7, PPP1CB, RPS8, RPS16, YWHAE, RPS14, RPS18, RPS13, RPS11, RPL7A, RHOB, GNB2, RPL30, RPL31, RPL10A, PPIA, RAC1, YWHAZ, RPL38, ACTG1, TPM4, ACTC1, ADAM17, ARF1, RPL19, DAB2, HSPG2, KIF23, MAP2K1, TEK, DST, GNA12, CAV1, PLAUR, PTK2, RPL18, AHNAK, NEXN, TWF1, G3BP1, PTK7, ILK, SNTB2, ADAM9, FHL1, ALCAM, SNTB1, DAG1, ARHGEF7, GIT2, CTTN, FLNC, NEDD9, FAT1, MDC1, KIF22, CNN3, DIXDC1, TRIP6, ZYX, CSRP2, ARHGAP31, DCAF6, TNS2, NHS, CSPG4, MPRIP, RHOU, CYFIP1, ARHGAP22, PHLDB2, PRUNE, ARHGAP24, ENAH, PDCD6IP, FBLIM1, PALLD, SYNE2, STARD8, ARHGEF2, LPP, TADA1, AJUBA, PDLIM2, DOCK7, DLC1, CHP1, ZFYVE21, AIF1L, FERMT1, CORO1B, SORBS1, SPRY4, TRIOBP, TRPV4, TNS1, NOX4, CASS4, PDLIM7, PARVA, AATF, EHD3, FLRT3, FLRT1, HACD3, TES, LIMD1, LAMTOR3, LIMA1, EVL, ITGA11, RAB21, CORO1C, SYNPO2, ARHGAP26, PROCR, GIT1, REXO2, TLN1, HYOU1

GO:0005929

CC

cilium

A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.

SNTN, AURKA, ADCY3, CEP104, TULP3, OFD1, DNAL4, TUBB4A, DLD, GLI3, PKM, CCT8, NEK4, EVC, PKD1, CAV1, DNAH14, PKD2, TTLL9, CFAP157, DNAH12, BBS12, NPHP3, NEK8, PKHD1L1, DNAH10, AHI1, BBS10, TTC8, TEKT1, CLUAP1, IFT43, TMEM80, IFT74, IFT27, TRPV4, IFT122, TMEM138, IFT46, TULP4, WDR35, DNAI1, INVS, ATP6V1D

GO:0005930

CC

axoneme

The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.

DNALI1, TULP3, GLI2, GLI3, MAPT, MAK, CENPF, SEPT2, SEPT7, ARMC4, RSPH4A, CCDC103, BBS7, CFAP46, PIK3C3, MNS1, BBS1, DYNC2LI1, DNAH5, KIFAP3, WDR34, AK8, DRC1, PIK3R4, MAP1LC3B, INPP5E, DNAH9, SPATA7, WDR35, DCDC2

GO:0005938

CC

cell cortex

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

AXIN1, COBL, FLNB, USP2, FGA, FGB, FGG, ANXA2, PFN1, FGFR2, CTGF, MARCKS, AKT2, CTNNB1, SNCA, PSEN2, GYS2, RHOA, GPSM2, DST, CAV1, COL10A1, PTK2, AKAP13, EPS8, MYO9B, ARHGEF7, CTTN, NEDD9, ITPR2, MELK, SEPT2, PRKD1, TRIP10, DBN1, FAM110C, FNBP1L, FRY, AGTRAP, C2CD5, CD302, PARD3, FBLIM1, FNBP1, NDFIP1, PARD6B, TLE6, MYO10, PARD6A, FMN2, CLIC5, BIN2, ADD3, MKLN1, MYO6, PLA2G4C

GO:0005940

CC

septin ring

A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.

SEPT6

GO:0005942

CC

phosphatidylinositol 3-kinase complex

A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.

PIK3CD, PIK3C2A, PIK3R1, PIK3CA, PIK3CB, PIK3C3

GO:0005943

CC

phosphatidylinositol 3-kinase complex, class IA

A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.

PIK3R1, PIK3CA

GO:0005944

CC

phosphatidylinositol 3-kinase complex, class IB

A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.

PIK3CG

GO:0005945

CC

6-phosphofructokinase complex

A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known.

PFKL

GO:0005947

CC

mitochondrial alpha-ketoglutarate dehydrogenase complex

Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity.

DBT, BCKDHA, BCKDHB

GO:0005952

CC

cAMP-dependent protein kinase complex

An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.

PRKAR1A, PRKAR2A, PRKACA, PRKAR2B

GO:0005953

CC

CAAX-protein geranylgeranyltransferase complex

A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.

PGGT1B

GO:0005955

CC

calcineurin complex

A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.

PPP3CA, ITPR1

GO:0005958

CC

DNA-dependent protein kinase-DNA ligase 4 complex

A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV.

PRKDC, XRCC4, XRCC6BP1

GO:0005960

CC

glycine cleavage complex

A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.

GCSH

GO:0005964

CC

phosphorylase kinase complex

An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.

PHKA2, PHKA1

GO:0005967

CC

mitochondrial pyruvate dehydrogenase complex

Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.

DLAT, PDK1

GO:0005968

CC

Rab-protein geranylgeranyltransferase complex

A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.

CHM, CHML, RABGGTB

GO:0005969

CC

serine-pyruvate aminotransferase complex

An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate.

EEA1

GO:0005971

CC

ribonucleoside-diphosphate reductase complex

An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.

RRM1, RRM2

GO:0005975

BP

carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.

AKR7A2, UGDH, PGLS, ALDH2, INSR, GPI, HEXA, LDHB, BPGM, SLC3A2, LCT, SLC2A3, ADRB3, SLC2A4, AKR1B1, FUT1, AMY2B, FUT4, SLC2A5, ALDH1B1, CHI3L1, TALDO1, SPAM1, PHKA2, IDH2, GALC, SLC35A1, GALK2, GLO1, GFPT1, FUT2, HYAL2, CHIT1, MLEC, GANAB, ATHL1, MDH1B, CHST3, GALNT7, GLB1L2, GALNT4, HHIP, NPL, CHST5, CHST6, DPM3, KL, SHPK, CNOT7, NAGPA, HPSE, CHST2, POMT1

GO:0005976

BP

polysaccharide metabolic process

The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.

CHST7

GO:0005977

BP

glycogen metabolic process

The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.

PPP1R3D, PYGM, G6PC, PPP1CC, IL6ST, PPP1R2, PHKA1, GSK3B, PPP1CA, PPP1CB, GBE1, PPP1R1A, PPP1R3A, PPP1R3B

GO:0005978

BP

glycogen biosynthetic process

The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.

GYG2, UBC, GYS1, NR1D1, AKT1, AKT2, AGL, PGM1, GYS2, RPS27A, UBA52, GBE1, UGP2, PGM2, PRKAG3

GO:0005979

BP

regulation of glycogen biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.

PPP1R3D, AKT1, PPP1CA, PPP1CB, PPP1R3F, PPP1R3B, INPP5K

GO:0005980

BP

glycogen catabolic process

The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.

GYG2, GAA, PYGB, PYGM, AGL, G6PC, PGM1, PHKA2, PHKA1, CALM2, PGM2

GO:0005981

BP

regulation of glycogen catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.

PPP1R3D, PPP1CA, PPP1CB, PPP1R3B

GO:0005983

BP

starch catabolic process

The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants.

MGAM

GO:0005985

BP

sucrose metabolic process

The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside.

GAA

GO:0005986

BP

sucrose biosynthetic process

The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside.

FBP2, FBP1

GO:0005989

BP

lactose biosynthetic process

The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose.

SLC2A1, B4GALT1

GO:0005997

BP

xylulose metabolic process

The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose.

DCXR

GO:0005999

BP

xylulose biosynthetic process

The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose.

TKT, TALDO1

GO:0006000

BP

fructose metabolic process

The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.

FBP2, PFKFB2, ALDOA, FBP1, ALDOC, PFKFB1, PFKFB3, PFKFB4

GO:0006001

BP

fructose catabolic process

The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose.

FBP2, FBP1

GO:0006002

BP

fructose 6-phosphate metabolic process

The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.

FBP2, FBP1, PFKL, TALDO1, GFPT1