Search Geneontologies

Geneontologies

GO ID Ontology GO Term Term Definition Proteins

GO:0005638

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lamin filament

Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.

LMNA, LMNB1, LMNB2

GO:0005639

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integral component of nuclear inner membrane

The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

P2RX4, TMEM43, SUN2, LEMD3

GO:0005640

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nuclear outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.

SNCA, LRPPRC, PSEN1, EMD, NUTF2, GUCY2D, DMPK, ITPR3, SYNE2, SIGMAR1, DHCR7

GO:0005641

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nuclear envelope lumen

The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.

PTGES, APP, TUBB, ALOX5, IGF2R, SORL1, CACYBP

GO:0005642

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annulate lamellae

Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.

XPO1, NUP62, EIF5A

GO:0005643

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nuclear pore

Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.

MYO1C, IPO5, KPNA3, KPNA4, KPNA5, NUPL2, TNKS, TPR, NUP62, RANGAP1, NUP153, RANBP2, KPNA2, KPNA1, AGFG1, NUP107, EIF5A, RAE1, NUP160, MAD2L1, KPNB1, NUP93, NUP210, IPO4, AHCTF1, NUP205, NUP88, PIK3R4, NDC1, NUP58, XPO4, EIF5A2, ENY2, PARP11, NXF1, NXT1, NUP50, NPIPA1, MAD1L1

GO:0005652

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nuclear lamina

The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.

CASK, NUP35

GO:0005654

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nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

PTPDC1, STRA13, DDX39A, ACOT7, MYO1C, SNAP23, EYA2, AIP, APBB1, PSMD11, PSMD12, SUPT5H, DFFA, CDC7, ARNTL, IPO5, SAP18, RTCA, GOLIM4, ELL2, NR5A2, KPNA3, VWA5A, NOP56, KPNA4, UBE2C, PDXK, ARID1A, COPE, CTDSP2, UTY, AP3D1, CHD2, ENC1, CHEK1, TFEC, AURKA, PPP1R12A, HNRNPDL, XPO1, BTAF1, U2SURP, ANKRD28, SMAD7, SCAMP1, SCAMP2, KPNA5, MDM4, POLR1C, SMAD9, FANCG, OGT, SIVA1, POLR3G, PPM1G, SOX12, HDAC3, BIRC5, CD3EAP, NUPL2, POLR2D, MAFG, KDM6A, ADAM12, PSMD3, RBFOX2, SIAH2, AP5Z1, PAX4, HOXA2, HOXA3, HNRNPR, PRPF3, PPIH, KLF4, OIP5, RAD51C, MED7, FOXO3, SPRY1, PLRG1, PRC1, BUB1, BUB3, ENSA, NUDT21, ORC5, RAD21, DHX16, PPP1R12B, MED14, SMARCA5, NUAK1, OPA1, KDM1A, HBP1, SYNCRIP, CCNT1, CCNT2, RAD1, REV3L, JAK2, UGDH, CDC14B, HIST1H2BK, PQBP1, DKC1, BRD4, TBL1X, NBN, MITF, FAM20B, ZC3H11A, RAB11FIP3, SIN3B, DNAJB6, NDUFS2, ZPR1, ZNF217, NCOR1, PRPF40A, POLQ, PSIP1, SUPT3H, SRSF10, GMNN, HSBP1, ECI2, KHDRBS3, TADA3, BANF1, SKAP2, PRKRA, CRCP, RPS6KA5, MED6, USP2, TRMU, UTP20, WDHD1, RAD51D, RNASEH2A, POP7, RPP40, PSMD10, STAM2, TNFSF13, ATP5H, CLPX, RNF8, USP1, TOX4, UBXN7, NFAT5, KDM4B, CEP152, HEXIM1, CCNB2, UBR5, FSBP, SCAF4, NDUFB6, NDUFB4, ZRANB2, LUC7L3, KIF20A, KIF4A, MBD4, SMC2, GDF11, CD2BP2, PSMG1, ETHE1, POLR1A, YEATS4, STAMBP, NFATC1, POP4, LSM8, ZMYM6, CBX7, MBD3, TOMM40, ACTL6A, CCNE2, WHSC1, DHFR, FOS, MYC, CRYAB, LMNA, ESR1, ANXA1, NR3C1, TP53, TYMS, GNAI2, ISG15, JUN, PRKCB, KRT8, UROD, RB1, PGR, PTMA, CDK1, GPI, NPM1, APRT, HSP90AA1, HNRNPC, ERCC1, NGFR, HSP90AB1, RPS17, RPSA, SNRPA, SNRPC, HMGB1, RBP1, CNP, DLD, HNRNPA1, SNRPA1, PARP1, POLA1, UCHL1, UBC, HSPA1A, HSPA1B, GLI2, GLI3, MYBL2, AR, NR2F1, TXN, THRA, IRF1, PDHB, TOP1, TOP2A, VDR, ESRRA, CDK4, PCNA, TPR, PTHLH, SKI, SKIL, XRCC5, UNG, RNH1, GTF2F2, HSD17B1, MIF, FDPS, CCNB1, SNRPB, IDE, POU2F1, HNRNPL, ETS1, ETS2, AKR1B1, FOSL2, HPGD, RPS2, RAG1, TCF3, NQO2, H2AFX, CREB1, GCFC2, ZNF12, ZNF22, HMGA1, PRKCA, JUNB, UBTF, ATF7, PRKACA, CEBPB, PTPN2, DDX5, XBP1, PSMC3, ERCC2, EGR1, SON, RCC1, ATF1, ATF3, ATF4, ATF6, LIG1, POLR2E, ELK1, NFKB1, CCNA2, NR1D1, MSH3, PSMB1, LMNB1, BCL3, FGFR2, SDHB, OSBP, RPS4Y1, SCP2, HNRNPA2B1, UQCRC2, NR4A1, XPA, SFPQ, SP100, RRM1, GADD45A, POLR2A, CDK2, APC, PTAFR, MCM3, NFYB, DNAJB1, PSMA1, PSMA2, PSMA3, PSMA4, DNMT1, CHML, HMGB2, PTBP1, MAPK3, ARNT, CAD, PSMB8, PSMB9, PSMB4, PSMB5, POLD1, MAPK1, RXRB, RBL1, LAP3, MPG, KDM5A, TKT, BLVRB, CDC27, CCND2, CCND3, WEE1, CDC25A, CDC25B, CDC25C, SRI, ALDH1B1, POLR2B, RRM2, TIA1, HIVEP2, AKT1, AKT2, HNRNPH3, HNRNPH1, GTF2H1, DUT, HIST1H2BB, MCM4, MCM5, MCM7, HSPA1L, CTNNB1, PHB, RPA3, RFC4, RFC2, GTF2F1, HRH1, RORA, FUS, DDIT3, DEK, SOX6, AHR, PSMC2, POLR2I, SREBF1, PPARG, ZEB1, RBMX, BRCA1, COIL, CDKN1A, ANP32A, FEN1, CAPG, PSMB10, PBX1, MLH1, STAT3, MDH2, RFC5, RFC3, ID1, ETV5, BCL6, UBA7, ELK3, STAT5A, SKIV2L2, RPS27, NCAPD3, LRPPRC, CDKN2B, HTT, MATR3, MSH2, NR4A2, NAMPT, PSMC4, GATA4, NKX2-1, CBX5, MAPK8, MAPK9, RECQL, CDKN1B, NOTCH1, BRCC3, RPS9, RPS5, RPS10, YAP1, SOX9, NRIP1, CSNK1D, MAPKAPK2, NASP, CDK8, CDC34, CENPA, CENPF, PRIM1, PRIM2, CSNK1E, PSMB3, MCM2, RBM25, CLK2, NUP153, RGS3, MRE11A, HNMT, ERF, CDK7, CCT8, ANXA11, PAPOLA, DAP3, DUSP3, DNA2, SMARCA2, SMARCA4, BRCA2, PSMD7, STAT5B, AFF3, NR0B1, HDGF, CCNG1, UBE2E1, HNRNPA3, HNRNPM, KPNA2, KPNA1, POLR2J, MAP2K6, STAT2, GTF2A1, GTF2A2, MSH6, RBM5, HMGA2, PLK1, CEBPG, POLR2K, SMTN, BLM, RARS, HIRA, ATXN3, ATXN1, ATN1, TERF1, PRKAG1, PRKAA2, RAD23B, NR1H2, CSE1L, VCP, MLLT10, CASP6, SEC13, SNU13, HNRNPH2, SUMO3, EIF3B, NDUFV3, ARPP19, POLE2, HDAC4, EIF6, PEX3, GEMIN4, NUP107, YBEY, TIRAP, HIST1H2BD, PTEN, PPP4C, ACTB, RPS20, CKS1B, UBE2D3, RPS3A, PSME3, STXBP1, SUMO2, DCAF7, NUTF2, RPS7, PPP1CA, PPP1CB, CALM2, PSMC1, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, SNRPF, LSM3, LSM6, SNRPD1, SNRPD2, SNRPD3, PSMC6, POLR2G, RPS6, HIST1H4A, HIST1H2BC, RPS25, RPS26, POLR2L, RBX1, RPS27A, UBA52, GRB2, TRA2B, YWHAZ, UBE2B, SKP1, RPS21, UBE2I, YBX1, HIST1H3D, CXADR, RPP30, GTF2I, PIP4K2B, SRPK2, OLR1, CCNA1, PRKDC, NTHL1, ADARB1, SARNP, CBX1, SMAD3, H3F3A, XIAP, FOXO4, RBM3, GTF2B, CDK6, CDK5, HSF1, HNRNPU, IRF9, MDM2, E2F1, INSM1, SET, SRSF2, RUNX1, RELB, FABP5, HMGCS1, SATB1, XPC, POU5F1, MEF2A, DHODH, KIF23, ALDH6A1, ID2, SP3, ID3, FKBP4, PPARD, CENPC, RELA, NOTCH2, TLE1, TLE3, REL, SRSF11, PRKCD, EXOSC9, MEF2C, GABPA, RING1, RAD51, PAX8, FMR1, SOX4, KHDRBS1, MCL1, POLE, PPARA, SRSF1, FOXM1, PPP3CA, PPID, SSRP1, NSUN2, RBBP4, NCBP1, EP300, SMAGP, FAAP100, CPSF1, TMEM94, SREBF2, ARHGEF5, FOXO1, TBL3, CDC20, SF3A3, ILF2, ILF3, FOXC1, TAF10, BNIP3, CSTF3, STRN3, COASY, ZBTB17, CHAF1B, NR1H3, TARDBP, MAPK7, PAK2, CBLB, PSMD2, GPS2, SRSF9, SRSF5, SRSF6, TRIM28, NMI, SKP2, MTA1, ITGB3BP, PPIL2, PPP2R5C, ORC1, ILK, XRCC4, PPIG, GOLGA4, FKBP5, NFATC2, SMAD4, BIRC3, SQSTM1, PRPF4B, EIF4EBP1, HDAC1, CAMK2D, TDG, DGKZ, CUL2, CUL3, CUL4A, CUL4B, TP53BP2, EXOSC2, KLF9, GTF2H2, C1D, CUX1, RUNX2, NFYC, CDK13, CIRBP, HNRNPD, DAG1, VEZF1, BOP1, MORC3, SPIDR, GIT2, POLA2, TFDP1, SIM2, ZMYM3, NPAT, E2F2, TRIM25, FAM50A, HES1, SLBP, RBM39, MCM6, ITPR3, MDC1, SMC1A, GINS1, LPIN1, PPP2R5D, CASP8, MEF2D, CHD4, ARID5B, MTF1, ZNF638, KPNB1, NR1D2, CUL7, NAA25, KIAA0101, WTAP, MORF4L2, SART3, NCAPD2, SUZ12, EXOSC7, POLD3, ACOX1, TCEAL1, PTGES3, NONO, PPP2R4, RNPS1, RBBP5, ERBB4, ZMYND11, ANKRD1, RPS6KA2, PCBP1, TCEB1, TCEB2, PUM3, RPS6KA1, NR0B2, RGN, TAF5, TAF11, TEAD4, TEAD2, TAF1C, TAF1A, NCOA2, TRIP10, JMJD1C, ELAVL1, TAB1, NCOA1, SMAD2, SMAD1, UBE2V2, STK11, ADIRF, USF2, EZH2, ZFHX3, ZIC1, ADRM1, UAP1, PKN1, PKN2, TAF12, SNAPC1, MAPK14, SNRNP35, HIF1A, IFI16, ZSCAN26, DUSP5, DECR1, KYNU, HIST2H2BE, DUSP6, DUSP7, HADH, PFKFB3, FAM110C, PDS5A, ERCC6L, TSR1, QRICH1, CHD9, TIMM50, GLYR1, ZBED5, LARP7, ARID4B, FLYWCH1, LIN52, FAM98B, PDCD4, C11orf73, IFI44L, CDCA8, SMUG1, TAF1B, SGOL2, ESCO2, ZNF326, CMPK2, CENPW, SGOL1, BCORL1, HABP4, EXOSC6, RBM48, ZC3H13, ARMC4, UBR4, PHF19, ACBD5, CPSF3L, DEPDC1, RSPH4A, RIF1, FAM208B, ICE2, SEL1L3, MSL1, INTS3, CDCA2, THOC7, JADE1, NIPBL, PWWP2B, JMJD6, FAAP20, PTRF, MIS18BP1, TATDN1, C16orf46, NFRKB, RFWD3, PPIP5K1, SHQ1, CCDC174, ZC3H14, LARP1, ATAD2, AGTRAP, SMARCD3, ANKRD12, ANKRD11, AFTPH, FIP1L1, CRTC3, ATF7IP, RAD9B, NSMF, CYHR1, KDM7A, RNF111, USP45, CENPU, RPS27L, ASXL2, CENPQ, MCM10, COPS6, EPM2AIP1, RAB11FIP2, CXXC5, ZNF367, PID1, SETX, HAUS6, EMSY, WAPL, SPRED1, CCDC91, RBBP6, HUWE1, CENPV, ZBTB33, SYVN1, PABPN1, PBRM1, USP48, CASZ1, ALYREF, CAND1, SPATA24, SLC26A11, CHD1L, GPBP1, RPS19BP1, CARM1, NCAPG2, CEP57, KMT5C, PPARGC1B, GATAD2A, DCP2, CREBRF, NAV2, MGA, ZBTB8OS, SUGP2, CCAR1, BAP18, KLHL7, SMC5, DHX37, YAF2, EFCAB13, SRRM1, FANCM, TRIM22, THNSL1, PM20D2, ZBED8, KMT2E, MAML2, CMTM8, CENPL, EID3, CCAR2, INTS1, APITD1, ASCC3, MPP5, FNBP4, TAB3, NKAP, COMMD1, EID2, KIAA1958, ABTB2, JMY, BANP, EIF1AD, ATG16L2, FANCB, HJURP, ZBTB34, RNF169, TNRC6A, PHC3, SETD9, ABCF1, GLIS3, DUSP18, MCPH1, VPS37A, KMT2C, ZMIZ2, BOD1L1, ARID1B, NUP37, NUP35, DBF4B, CMAS, CASC5, NEK11, CEP70, MFSD8, THOC2, WDR36, MPLKIP, SMARCC2, ZNF420, NEIL3, ZCRB1, TRPM4, HELQ, NEK7, MORC4, DCAF11, SH3RF2, UTP15, GEMIN5, SMCR8, PNISR, SETD7, FAM222B, PPIL4, GTF3C2, PPP1R13L, HDAC7, GATAD1, CHTF18, SNRNP27, TSEN15, ZFPM2, SLC44A1, PRPF31, SREK1, GEMIN6, ATRIP, PSPC1, SYNE2, BBX, KAT6B, AHCTF1, KCTD13, RFFL, TOPBP1, BAP1, NR4A3, HSPH1, NUP205, ANKS1A, DYRK2, GTF3A, RAD54L, ESR2, TNR, GTF2H4, HDAC2, CREBBP, KAT6A, SYMPK, EZH1, TAF15, KAT2B, DDX17, RAD50, ERCC4, UFD1L, GATA6, SMARCC1, KHSRP, SNAPC3, EMG1, ATP6V0A1, RBPMS, MED12, HIST1H2BH, POP5, FBXO32, L3MBTL2, ITFG2, PMEPA1, UTP4, TP53INP1, FUBP1, NABP1, CLUAP1, ACD, EME1, ISG20, RAD51AP1, EXOSC8, TADA1, SYTL4, OPTN, NUDT16, ANAPC16, SNRNP40, MBD6, ZBTB10, ELP4, DAZAP1, MVB12A, NRBF2, CDCA5, DPH3, AURKB, MASTL, LIN37, CENPN, TONSL, SENP5, CDKN2AIPNL, MED30, INTS4, THOC3, EAF1, MAML3, CHAMP1, FEM1C, EHMT2, ZFR, PRMT6, C9orf72, RNPC3, HS6ST2, NOL4L, ZNF641, SPATA13, TOX2, RPRD1A, UHRF2, NEDD4L, FAM193B, TRNT1, KIF20B, PPP1R10, PHF12, MAGI1, SPAG5, SNX18, NR1H4, MED15, USP28, TRIB3, TP53RK, CCNL2, SMC6, DCLRE1C, VWA9, SECISBP2, RSF1, RBM15, SPEN, SETDB2, FAM129B, YME1L1, CDC5L, NUP88, SCAF11, TEAD3, TIMM17A, DNAJC7, COPS8, RAD9A, PKMYT1, MGLL, SMAD5, BARD1, HNRNPAB, LITAF, CDC6, NPAS2, EPAS1, CIB1, ARID3A, PRMT1, PKP2, VRK1, MAPKAP1, NABP2, ELAC2, MYBBP1A, PYGO2, GINS4, GINS3, CENPK, RHNO1, POLR3GL, WAC, DCTN5, IER2, CENPO, MKNK1, POLR3C, HNRNPUL1, RPP25, MENT, HTATIP2, DDX23, SNRNP25, DSCC1, MLST8, PHF20, GNL3, TIPIN, RBM4, SF3B5, CDCA7, PAPOLG, SORBS1, TM2D1, CLEC7A, OSBPL1A, FANCD2, HDAC8, POLDIP3, DUSP16, NIFK, HELZ2, MRPS26, WHSC1L1, ASPSCR1, TBL1XR1, PRKD2, TRIM8, LRRCC1, XPO4, ZNF436, WDR12, SENP6, POLR1E, PEG3, CTDSP1, ZNF350, RNF38, RACGAP1, CCDC113, DDX47, DNTTIP1, BCL11A, ANAPC1, POLR3F, ASCC2, UPF3A, CDT1, EPC1, TSPYL2, BLZF1, IKZF4, HIPK2, PNN, FOXP1, KCTD10, CENPH, SENP3, SMARCAD1, PCIF1, C11orf1, SUV39H2, TAF1D, FAM96A, OBFC1, SOX17, ESRP2, EGLN3, SMYD3, WDR26, METTL17, SUDS3, PHAX, UBE2Z, NOL11, MED20, AKIRIN1, COPS7B, MEAF6, SAP30L, PLEKHA5, SMURF2, CACYBP, FANCE, RC3H2, PATZ1, MKNK2, VEZT, TAF9B, ETNK1, ZBTB20, NEK6, METTL14, CWC22, CHD8, TCF7L1, POLD4, SRA1, RANGRF, EXOSC4, UBE2T, NOP10, BRD7, MED4, TIMMDC1, AKIP1, HEYL, ANO2, TCF7L2, KMT5A, EXOSC3, ANLN, ACSS2, ASH1L, MBNL1, SLC2A4RG, INIP, GLRX2, RAD18, CENPM, BMP2K, PDS5B, SMC4, POT1, DCAF13, MED17, INTS7, FANCI, ASF1B, INTS10, RLIM, HAUS2, POLR3B, RBM22, ARGLU1, SLTM, PARPBP, PAK1IP1, AURKAIP1, GID8, HYPK, SYBU, ZDHHC7, ING3, CDKN2AIP, NSMCE4A, GAR1, DACT1, BCLAF1, MIS18A, CDK12, RRN3, GTSE1, EHF, GRHL1, DTL, LMCD1, CWC15, CCDC59, NDUFA13, H2AFY2, HMG20B, ZNRD1, FNIP2, KLHL8, CPSF2, MYEF2, KANSL3, STARD9, NFKBIL1, DNMT3B, ORC3, SAE1, NLK, PPARGC1A, ASH2L, POLK, DBF4, MORF4L1, NXF1, TJP2, DNAJB4, ADD3, EPHA6, ZRANB1, PRKAG3, KDM5B, PARP2, TCF20, TRPS1, IP6K2, DDX20, BAIAP2L1, SAP30BP, PUF60, ZNF639, MUTYH, BAZ1B, CNOT7, SERPINB13, ZMYM5, MCM8, TRMT6, TUBD1, CDC23, ANAPC5, ANAPC4, GGA1, NOCT, LSM7, FEM1B, MRTO4, TNIK, PITPNC1, NXT1, GTF3C4, FBXO5, HDAC9, AGO2, NUP50, ZHX1, INTS6, BLOC1S6, ZMIZ1, TPX2, NOB1, MAFF, PADI4, FZR1, ANAPC10, MYO6, PLAGL1, KMT2B, NFU1, PRPF19, SUFU, NENF, NDRG2, POLI, STUB1, CDC14A, PPIE, DIMT1, TIMELESS, WDR3, NSFL1C, PLA2G4C, SCAF8, TRIM33, SRRM2, PA2G4, EXO1, SMC3, HDAC5, ZNF148, RUVBL2, CDYL, AKT3, POMP, GINS2, HPSE, RNF6, POLH, PRELID1, RUVBL1, ASF1A, BTRC, KDM2A, DIS3, FAN1, HIF3A, RCL1, DDX52, POLR1D, THRAP3, MED16, POLR3K, FCF1, LSM2, RRP7A, SBDS, SF3B6, FAM96B, HDGFRP3, RTCB, NOC2L, SAMHD1, L3MBTL1, ZNF175, MTF2, TRRAP, LOXL2, WIPI2, LAS1L, LSM5, LSM4, SUPT16H, UTP18, HEY1, ORC6, RBM8A, HCFC2, NCOR2, MRPS18B, EID1, STK24, CABIN1, NCOA3, DDX49, DUSP10, IVNS1ABP

GO:0005655

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nucleolar ribonuclease P complex

A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.

POP7, RPP40, POP4, RPP30, POP5

GO:0005656

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nuclear pre-replicative complex

A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.

ORC3

GO:0005657

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replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

CHEK1, RAD51C, NBN, RAD51D, TP53, PCNA, H2AFX, DNMT1, BCL6, UBE2B, UHRF1, PIF1, RAD18

GO:0005658

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alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

POLA1, MCM3, POLA2

GO:0005662

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DNA replication factor A complex

A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.

PLRG1, XPA, RPA3, PURA, TONSL, PURB, CDC5L, PRPF19

GO:0005663

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DNA replication factor C complex

A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.

PCNA, RFC4, RFC2, RFC5, RFC3

GO:0005664

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nuclear origin of replication recognition complex

A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.

ORC5, MCM2, ORC1, REPIN1, ORC3, LRWD1, ORC6

GO:0005665

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DNA-directed RNA polymerase II, core complex

RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

POLR2D, URI1, POLR2E, POLR2A, POLR2B, POLR2I, POLR2J, POLR2K, POLR2G, POLR2L, POLR2J2, PPARGC1A

GO:0005666

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DNA-directed RNA polymerase III complex

RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

POLR1C, POLR3G, CRCP, POLR2E, POLR2K, POLR2L, POLR3GL, POLR3C, POLR3F, POLR3B, POLR1D, POLR3K

GO:0005667

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transcription factor complex

A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

E2F8, PDLIM1, HAX1, ARNTL, MEIS1, SMAD7, SMAD9, MED7, SMAD6, LDB2, KDM1A, CREG1, FOS, JUN, PARP1, CDK4, SKI, SKIL, HCLS1, ETS1, TCF4, TCF3, HMGA1, JUNB, JUND, TAL1, CDK2, YY1, LMO2, RBL1, HOXA10, CTNNB1, AHR, ZEB1, PBX1, PBX2, NKX2-1, YAP1, SUB1, LMO4, PRKDC, SMAD3, MEF2A, POU3F1, CREM, RELA, REL, EP300, SMAD4, RUNX2, TFDP1, E2F2, NFATC4, ANKRD1, TEAD2, SMAD2, SMAD1, ZFHX3, HIF1A, ATF7IP, MINA, ARNTL2, NR4A3, GATA6, HES6, AJUBA, PITX2, SMAD5, NPAS2, EPAS1, NAA15, SOX17, BEX1, TCF7L1, MED17, RCOR3, LIMD1, TRPS1, DACH1, HDAC9, MAFB, IVNS1ABP

GO:0005668

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RNA polymerase transcription factor SL1 complex

A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.

TAF1B, TAF1D

GO:0005669

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transcription factor TFIID complex

A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

EDF1, TP53, ERCC1, TAF10, TAF5, TAF11, TAF12, ERCC4, TAF9B

GO:0005671

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Ada2/Gcn5/Ada3 transcription activator complex

A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues.

MAP3K7, TADA3, DR1, KAT2B, SGF29, CSRP2BP, POLE4, POLE3, YEATS2

GO:0005672

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transcription factor TFIIA complex

A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).

GTF2A1, GTF2A2, GTF2A1L

GO:0005674

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transcription factor TFIIF complex

A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation.

GTF2F2, GTF2F1

GO:0005675

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holo TFIIH complex

A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.

ERCC2, GTF2H1, CDK7, GTF2H2, GTF2H4

GO:0005677

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chromatin silencing complex

Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.

SMARCA5, SIRT2

GO:0005680

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anaphase-promoting complex

A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.

UBE2C, BUB1B, CDC27, CDC20, CUL7, UBE2S, CACUL1, ANAPC16, ANAPC1, CDC23, ANAPC5, ANAPC4, FZR1, ANAPC10

GO:0005681

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spliceosomal complex

Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

DDX39A, HNRNPR, PRPF3, PPIH, DHX16, LSM8, HNRNPC, SNRPA, HNRNPA1, SNRPA1, SNRPB, LGALS3, HNRNPA2B1, HNRNPH3, BUD31, RBM25, HNRNPM, RBM5, SNRPF, LSM6, SNRPD2, SNRPD3, SNRPN, SRSF2, SF3A3, RHEB, ZNF326, DHX32, CCAR2, SREK1, RBM17, PRPF18, WAC, CRNKL1, CWC22, CWC15, PTBP2, TTF2, SCAF8, LSM5, LSM4, IVNS1ABP

GO:0005682

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U5 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U5.

CD2BP2, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPN, SNRNP40, PRPF18, DDX23

GO:0005683

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U7 snRNP

A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs.

SNRPB, SNRPF, SNRPD3

GO:0005684

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U2-type spliceosomal complex

Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends.

PRPF31, SF3B6

GO:0005685

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U1 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U1.

PRPF40A, LUC7L3, SNRPA, SNRPC, SNRPB, SNRPF, SNRPD1, SNRPD2, SNRPD3, SNRPN, PRPF39, LUC7L, LUC7L2

GO:0005686

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U2 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U2.

SNRPA1, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPN, SF3B5, RBMX2, SF3B6

GO:0005687

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U4 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U4.

SNRPB, SNRPF, SNRPD1, SNRPD2, SNRPD3, SNRPN, PRPF31

GO:0005688

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U6 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U6.

LSM3, LSM6, LSM7, LSM2, LSM5, LSM4

GO:0005689

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U12-type spliceosomal complex

Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site.

DHX15, SNRPB, SNRPF, SNRPD1, SNRPD2, SNRPD3, YBX1, SNRNP35, ZCRB1, RNPC3, SNRNP25, SF3B5, LSM7, SF3B6

GO:0005690

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U4atac snRNP

A ribonucleoprotein complex that contains small nuclear RNA U4atac.

PRPF31

GO:0005691

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U6atac snRNP

A ribonucleoprotein complex that contains small nuclear RNA U6atac.

SART3

GO:0005694

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chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

GTPBP10, HMGB3, CD3EAP, RAD21, RAD1, POLQ, TADA2A, RECQL4, KIF4A, IL33, WHSC1, CENPB, BRCA1, RECQL, CENPE, FMR1, SSRP1, LRMP, PRPF4B, MDC1, SMC1A, ZMYND11, PUM3, PPP1R7, PDS5A, CDCA2, FAAP20, WAPL, RBBP6, SIRT2, TOP6BL, ZBTB38, BOD1L1, GSG2, SETD7, TOPBP1, UTP4, CDCA5, DDX27, ZFR, SETDB2, LLPH, RHNO1, NUSAP1, WHSC1L1, KMT5A, ASH1L, PDS5B, INTS7, DTL, HMG20B, ZBTB4, NSFL1C, SMC3, LOXL2, SUPT16H

GO:0005697

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telomerase holoenzyme complex

Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.

DKC1, HNRNPC, SNRPB, SNRPD3, HNRNPU, PTGES3, TEP1, NOP10, GNL3L, GAR1, SMG5

GO:0005712

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chiasma

A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over.

MLH1, PMS1, MLH3

GO:0005719

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nuclear euchromatin

The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.

KLF4, JUN, H2AFZ, CREB1, HIST1H1C, CTNNB1, RBMX, HIST1H1A, CBX3, TRIM28, ALKBH1, NSMF, NR1H4, PPARGC1A, ASH2L, RUVBL2

GO:0005720

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nuclear heterochromatin

A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.

H2AFZ, HIST1H1E, TCP1, CBX5, ATRX, CBX1, SATB1, FOXC1, CBX3, TRIM28, KMT5C, SIRT2, EME1, UHRF2, UHRF1, MPHOSPH8

GO:0005721

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pericentric heterochromatin

Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.

H2AFY, DNMT1, CBX5, ATRX, CBX1, CENPC, KMT5C, HELLS, LRWD1, BAZ1B

GO:0005726

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perichromatin fibrils

Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts.

TARDBP, NUFIP1

GO:0005730

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nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

GTPBP10, MIF4GD, AGPS, MYO1C, IPO5, PLK4, BTN3A3, ZNF593, NOP56, NFIB, BHLHE40, CHD2, ENC1, CASK, XPO1, SMAD7, PLSCR1, CETN3, UBD, FANCG, CD3EAP, DHX15, PLRG1, ZNF207, ASNA1, SMARCA5, NUAK1, REV3L, CDC14B, DKC1, EDF1, DIAPH2, NBN, NOL3, N4BP1, ZPR1, H2AFY, PEX14, TULP3, DAB1, NPM3, UTP20, RSL1D1, FGF18, SRP72, IKBKAP, SNAPIN, SMC2, TACC2, PARN, NSA2, TDP2, POLR1A, MYC, ANG, CSTB, TP53, TYMS, KRT18, NPM1, CTSB, NFIC, SNRPA, HMOX1, PARP1, POLA1, MAP2, TOP1, TOP2A, ESRRA, CDK4, XRCC5, EZR, GCFC2, UBTF, DDX5, RPL7, ATF3, WT1, NCF2, FLNA, OSBP, DNAJB1, HMGB2, PTBP1, KDM5A, EEF1D, RPL12, CCND2, WEE1, NF2, RPL4, PPP1CC, POLR2I, COIL, CDKN1A, FEN1, CAPG, RPL13A, RGS2, SKIV2L2, PIK3CB, RPL35, CBX5, MKI67, NOP2, RPL5, RPL21, RPS9, RPS10, NRIP1, RPL34, CDK8, ARL4D, ACADVL, NUP153, MXI1, FXR1, NOVA1, SMARCA4, NEK2, HNRNPM, PLK1, TTC3, SUB1, BLM, TERF1, SNU13, EIF6, GEMIN4, NLRP5, SRP54, YPEL3, RPS3A, RPS7, PPP1CA, PPP1CB, RPS14, RPS13, RPS11, LSM6, RPL7A, RPL23A, RPS6, RPS25, RPS26, RPL10A, RPL11, RPS27A, GRB2, EEF1A1, PAFAH1B2, SRPK2, RAE1, PRKDC, ADARB1, RPL19, ZBED6, DAB2, RBM3, SLC25A3, GTF2B, MDM2, SPTBN1, XPC, EWSR1, TLE1, ZBTB16, EXOSC9, RAD51, FMR1, RPL18, C1QBP, PPID, SSRP1, NSUN2, TBL3, ILF2, ILF3, CHAF1A, SELENBP1, SRSF9, SRSF5, SKP2, SLC14A1, ORC1, TCOF1, TRA2A, PWP1, CUL2, EXOSC2, C1D, CIRBP, VEZF1, BOP1, EIF3A, RCN2, ITPR3, ITPR1, RRP1B, MORF4L2, SEPT2, SUZ12, EXOSC7, RRS1, ACOX1, NONO, RBBP5, ANKRD1, PUM3, ZFHX3, SEPT7, SNAPC1, MRPL23, IFI16, KNOP1, TSR1, CERKL, MIDN, CDCA8, SMUG1, NOM1, CENPW, RRP12, ZNF506, DNTTIP2, EXOSC6, RSPH4A, ATF7IP2, ARL6IP4, SPTY2D1, JMJD6, INO80C, ZC3H14, WDR74, C6orf89, KDM7A, RNF111, NOL8, ZNF771, MCM10, SETX, RBBP6, PCGF5, ZBTB33, MTDH, JAZF1, SPATA24, RPS19BP1, MINA, DHX40, KLHL7, DHX37, ZCCHC7, NIN, ZCCHC9, OXR1, AOPEP, ZNF655, KRI1, SPC24, INO80E, HJURP, PAPD5, NGDN, NEK11, WDR36, DDX54, HELQ, STK35, UTP15, SETD7, ZC3H15, PHLDA1, TRIM41, UBLCP1, TSEN15, PSPC1, PPM1E, ARNTL2, H1FX, RTF1, MRPS31, ANP32B, P3H4, KAT6A, DDX17, FGF13, EMG1, MED12, UTP4, EME1, ISG20, EXOSC8, CHCHD1, NUDT16, MBD6, S100A16, ZNF274, VMP1, CDCA7L, DDX27, SENP5, CDKN2AIPNL, ABHD14B, KIF20B, YPEL2, ERGIC2, USP28, FAM129B, CDC5L, MPHOSPH8, SCAF11, TXN2, EBNA1BP2, ARID3A, HAUS7, VRK1, RBM4B, MYBBP1A, LLPH, UTP23, FAM64A, DDX23, THUMPD3, GNL3, HIRIP3, ACAT2, RBM4, HINT2, NUSAP1, FANCD2, NIFK, MRO, INO80B, WDR12, DDX24, POLR1E, KATNBL1, USP44, DDX47, THAP2, DNTTIP1, TSPYL2, SENP3, OBFC1, NOL11, DDX31, AKTIP, ELP3, LIN28A, MEAF6, SAP30L, SP110, MKNK2, MYO10, EXOSC4, NOX4, MRPL40, EXOSC3, SNX15, BRWD1, MDN1, STAU2, DDX28, SPATS2L, DCAF13, GNL3L, SDAD1, THAP1, GPATCH2, PAK1IP1, LYAR, ZDHHC7, ING3, CDKN2AIP, GAR1, AATF, BCLAF1, CDK12, RRN3, FMN2, GPRC5B, IL37, DTL, GLTSCR2, THYN1, CRIPT, USP36, CHD7, KANSL3, DNAJB9, PARP2, NOL12, NUFIP1, HN1, MRTO4, PNMA3, PNMA2, TAOK2, PYCARD, PHTF1, NOL7, DIMT1, TIMELESS, WDR3, PA2G4, NIP7, PIN4, KDM2A, RCL1, DDX52, CRYL1, POLR3K, FCF1, SBDS, REXO2, ZNF330, NOC2L, RPL36, LAS1L, UTP18, SPIN1, STK24

GO:0005732

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small nucleolar ribonucleoprotein complex

A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type.

NOP56, SNRPF, LSM6, SNRNP40, NAF1, NOP10, LSM7

GO:0005736

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DNA-directed RNA polymerase I complex

RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

POLR1C, CD3EAP, POLR1A, POLR2E, POLR2K, POLR2L, POLR1E, ZNRD1, POLR1D

GO:0005737

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cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

UBA6, SH3PXD2B, FRMD3, PTPDC1, MEIOC, KIAA0922, TMEM189, CNOT1, CCDC42B, ASB14, GOLGA8A, C4orf47, BBIP1, MIF4GD, AHRR, FAM195B, NACA, DDX39A, PDLIM1, ACOT7, MYO1C, SNAP23, AIP, TLR4, APBB1, PSMD12, DFFA, HIP1, CLIC1, WWP2, CDC7, IPO5, SAP18, IGF2BP3, PIK3C2A, IFRD1, EXOC5, ELL2, BTN3A3, NR5A2, BIN1, KRIT1, SDCBP, NOP56, DDX3X, UBE2C, PDXK, SOCS2, SOCS3, SOCS6, ARHGAP33, DYNC1I1, CCS, ABLIM1, DNALI1, CHD1, ADAM10, ENC1, ITGB1BP1, MAP2K7, PDCD5, TNPO2, TNFSF11, MSTN, BACH1, IRF6, TAX1BP3, RGS12, CASK, TFEC, RAB29, PPP1R12A, AZIN1, HNRNPDL, XPO1, PDZD2, MAST4, PFAS, NACAD, SMAD7, KPNA5, ARPC2, AXIN1, SMAD9, UBD, PFDN6, ZNF185, FANCG, SIVA1, INPP4B, HMGB3, PPM1G, HDAC3, BIRC5, CD3EAP, TLR3, P4HA2, MAGEB4, CAPN5, NUPL2, CFLAR, SOCS1, CYP27B1, PER1, RGS5, DHX15, FLRT2, ARHGAP6, IRAK2, PSMD3, RBFOX2, SIAH2, SPINT2, DAPK3, TGFB1I1, AP5Z1, CTIF, MTSS1, MAP3K7, EEF1E1, RIPK2, PRPF3, PPIH, KLF4, OIP5, CACNA1G, RAD51C, FOXO3, SMAD6, AKAP10, SPRY1, SNAI2, PRC1, ZNF207, ASNA1, BUB1, ACTN4, SGTA, ENSA, C21orf2, AHCYL1, CD5L, ORC5, DHX16, SH3BP5, SOX15, PARK2, ADCY3, KIAA0513, SPAG9, KIF5C, NUAK1, TRAK2, LZTS3, OPA1, TBC1D4, NUPR1, GDF9, BRINP1, ACSL4, SNX3, RANBP6, GMDS, NMT2, BUB1B, TLR2, JAK2, PRMT3, SRPX2, LPXN, CTNND1, CDC14B, HIST1H2BK, PQBP1, DKC1, EIF5B, GAS7, EDF1, BRD4, PPP1R11, WDR1, AOC2, MFAP3L, OBSL1, TSC22D2, SOCS5, SIN3B, GADD45B, ZPR1, PDCD6, VPS4B, FLNB, ULK1, TULP3, PRPF40A, TACC1, MAF, ERN1, SRSF10, GMNN, BANF1, SKAP2, PRKRA, RPS6KA5, LYPLA1, ADAP1, UTP20, RP2, WDHD1, RAD51D, RNASEH2A, CDC123, PPP1R15A, CAPN15, POP7, PSMD10, IDH1, STAM2, TNFSF13, ALDH1L1, GABBR2, PAK3, ATP5H, SASH3, CLPX, SEC14L2, RNF8, ZFAND5, SRP72, DXO, RECQL4, URI1, ALDH1A2, TPPP, SLIT2, PLEKHG5, FARP2, LRIG2, PROSC, ERLIN2, NFAT5, ABLIM3, KDM4B, WDR47, TRIM37, SEC31A, HEXIM1, UBR5, FSBP, UBE4B, IKBKAP, OAZ2, SNX4, ZWINT, KIF4A, GADD45G, VAPB, CELF2, SMC2, TACC2, LYPLA2, WISP1, BMP10, CD2BP2, PARN, PSMG1, CTDNEP1, SLC2A10, TDP2, ETHE1, POLR1A, PCNT, STAMBP, NFATC1, EYA4, APBB3, SNAP29, ZMYM6, STAU1, MAP4K4, CLIC3, EML2, DDAH2, C6orf47, TTLL1, CBX7, BMP15, MBD3, NUDT3, PTTG1, BCL10, ZBED1, TOMM40, DNAL4, WHSC1, CYB5A, ALDH1A1, CYB5R3, PNP, EGFR, AK1, PLAT, ADA, CA2, ASS1, AGT, CSTA, KRAS, PDGFB, TGFB1, POMC, FSHB, CRYAB, LMNA, APOE, PMP2, TTR, FTL, FTH1, MT2A, BGLAP, ESR1, RAF1, FUCA1, CSTB, ANXA1, APOB, NR3C1, PRNP, S100B, GAPDH, ERBB2, TP53, MT1E, MT1F, HSPB1, TYMS, GNAI2, APP, INHA, HMGN2, IL6, EDN1, RPLP1, RPLP0, CLEC3B, ITGB1, PRKCB, KRT18, KRT8, UROD, PTMA, CDK1, S100A6, EIF4E, ENO1, GPI, NPM1, TH, LDHB, GPX1, DCN, PSAP, PFN1, APRT, EPRS, HSP90AA1, LYN, FH, ERCC1, SLC3A2, HSP90AB1, SOD3, MME, VIM, CYP3A4, KRT7, GNAI3, ANXA5, RPSA, SNRPA, GSTP1, LGALS1, QDPR, RBP1, FBP1, SPARC, GSTM1, ANXA4, CNP, WNT2, PDGFRB, HNRNPA1, POLA1, UCHL1, GSTT2, TMSB15A, HSPA1A, HSPA1B, GLI3, CCL3, TROVE2, AR, BCL2, TXN, PRKAR1A, HSPD1, CLU, IRF1, MAP2, EGR2, UMPS, PYGB, PYGM, LAMP1, G6PD, PC, ODC1, PCNA, NEFH, HARS, TPR, PTHLH, CKB, ANXA3, SKI, ACTN1, RNH1, CCL5, CFTR, NCAM1, EEF2, MT1G, TPT1, LCP1, PRKAR2A, ENO3, HSD17B1, MIF, CD99, HCLS1, FDPS, PKM, CCNB1, TYR, IDE, HNRNPL, DARS, ETS1, JUP, LIF, ETS2, FABP4, AKR1B1, PVR, EZR, UCHL3, HPGD, NME1, NQO1, VEGFA, CD1D, RPS2, CHN1, TCF3, DSP, CD44, NQO2, PDGFRA, STMN1, HSPA6, PRKCA, ATF7, CEBPB, GAP43, XBP1, LGALS3, ERCC2, RPL7, EGR1, IL1RN, PGAM1, RCC1, SDC1, ATF4, CDH2, TFEB, WT1, NFKB1, NCF2, CCNA2, BTF3, RAB3B, RAB5A, NR1D1, BCL3, MAK, CAPN3, IL11, CAST, HNF1A, MAG, RASA1, PDC, CDK11B, GSTM3, FLNA, TNFAIP3, KITLG, NT5E, MDK, ZP3, FGFR2, BGN, BMP6, OSBP, PCMT1, PAICS, IL10, SCP2, UBA1, NME2, HNRNPA2B1, CALB2, NR4A1, XPA, PTGS1, SFPQ, TUBG1, JAK1, SP100, AHCY, CFL1, BDNF, RRM1, GADD45A, EEF1B2, CDK2, APC, BRD2, FAS, YY1, DNAJB1, MT3, PSMA3, PSMA4, S100P, CTNNA2, CHML, HMGB2, TARS, ZFP36, ACVR2A, STOM, ARNT, CALR, IL1R2, PIK3R1, PSMB9, GSTM2, SSFA2, POLD1, MAPK1, DUSP1, PTPRM, LAP3, TNFRSF8, PTPN4, TPP2, IMPA1, KDM5A, IL12A, NOS3, SERPINB3, LMOD1, EEF1D, GNA11, PBLD, PRDX6, BLVRB, DDT, CMPK1, CDC27, CCND3, WEE1, CDC25B, ADSS, TSPO, CLIP1, SRI, SERPINB1, SSTR1, CORO1A, GDI1, S100A7, HOXA10, PRKAR2B, RRM2, FGF9, TIA1, AKT1, HNRNPH1, YWHAB, SFN, S100A11, PRDX2, CTH, HIST1H2BB, MAN1A1, TTK, MCM7, SHMT1, GRK5, USP6, CA8, CTNNB1, PHB, NF2, RPL22, ADM, SPRR2B, PTGS2, HRH1, CBS, PCK1, IRS1, AGL, MYH9, AHR, FLT4, PSMC2, CHI3L1, MAP2K2, CPOX, RPL4, NUDT1, PGM1, PPP1CC, SERPINB5, SREBF1, GMPR, SRP14, NUP62, ZEB1, TALDO1, SNCA, BRCA1, ANP32A, CAPG, CCT6A, PBX1, RPL13A, STAT3, MDH1, EIF2S3, LEP, MNDA, RGS2, CSK, MAP3K8, EIF1, HTR2B, PRKCI, ACTR1B, STAT5A, AKR1C3, EPS15, RPL35, CDKN2B, CDKN2C, NSG1, HTT, PTGFR, NR4A2, PTPN9, SYK, RANBP1, PSMC4, PPIC, MKI67, RANGAP1, RECQL, NSF, CDKN1B, BRCC3, RPL5, RPL21, RPL28, RPS9, MAP1B, GNPDA1, YAP1, IQGAP1, PLA2G4A, ALDH1A3, ID4, LGALS7, ZFP36L2, PREP, GLRB, RFX2, ARCN1, SERPINB4, PRRC2A, NES, PIK3CG, MAPKAPK2, ALDH9A1, RPL34, TGM4, SLC11A2, NASP, FASN, DHPS, CCT3, ALDH7A1, CDC34, INPP1, CENPF, UBE2A, SARS, CSNK1E, ARL4D, PSMB3, MCM2, ACADVL, RBM25, HINT1, FHIT, NUP153, RGS3, RGS4, TSC2, GSK3B, SEPHS1, MTHFS, GMPS, CDKN1C, MRE11A, HNMT, GNAQ, MEOX1, MMP14, GDI2, SERPINB9, MXI1, METAP2, CDK7, KNTC1, RPL14, CCT8, ATP1A2, ANXA11, PAPOLA, FXR1, RAB28, FABP6, PLCD1, DUSP3, BRCA2, IRAK1, STAT5B, USP11, VAMP7, PRKX, AFF3, NR0B1, HDGF, NEK2, NEK3, NEK4, HNRNPA3, KPNA2, KPNA1, MAP2K6, ARHGDIB, STAT2, GTF2A1, MSH6, KIF11, HRSP12, STC1, AKR1C2, PLK1, DAPK1, SUCLG1, COPA, LIMK2, PTTG1IP, TTC3, RCAN1, SMTN, BLM, RARS, ATXN3, ATXN1, ATN1, TERF1, OAZ1, YARS, PRKAA2, RAD23B, EPHA4, GYS2, EMP2, ALDH18A1, EIF5, NR1H2, CSE1L, VCP, MLLT10, CASP6, CDH11, CDH13, TPD52, GFER, HNRNPH2, SUMO3, EIF3B, DLX5, ARPP19, HDAC4, EIF6, SIK1, SOX8, GEMIN4, EVC, SESN2, SESN3, EPPK1, TIRAP, HIST1H2BD, PTEN, PPP4C, GABARAPL2, ACTB, EIF4A1, RPS20, SNAP25, CDC42, SRP54, CXCR4, UBE2M, ACTR2, ABCE1, RPS3A, PSME3, STXBP1, B2M, PKIA, UFM1, DCAF7, RPS7, PPP1CA, CALM2, NCS1, PSMC1, RPS8, RPS15A, UBE2H, RPS14, RPS11, SNRPD3, BTG1, TMSB4X, RPL7A, ACTA2, RPL23A, RPS6, HIST1H2BC, RAP1A, RPS25, RPS26, RPL30, RPL10A, RPL11, RPS27A, GRB2, RAC1, GNAI1, YWHAZ, UBE2B, SNRPN, DYNLL1, SKP1, RPS21, EIF5A, RACK1, ACTG2, UBE2I, TMSB10, YBX1, ACTC1, EEF1A1, PAFAH1B2, CXADR, IGBP1, ADAM8, GTF2I, DLG4, SRPK2, CCT2, RAE1, IRX3, GSTO1, ADAM17, ELF3, MAP1A, CRADD, ADARB1, GPLD1, MT1H, MT1X, GPSM2, SSBP2, RPL24, SMAD3, RPL19, MUC5AC, PKD1, XIAP, FOXO4, RBM3, PITPNA, HDLBP, CDK6, CDK5, CDK16, PURA, HSF1, IRF9, MDM2, PLIN5, SPTBN1, SET, RUNX1, RELB, GALK2, FABP5, HMGCS1, SLC7A5, MC2R, XPC, EWSR1, POU5F1, BNC1, OCRL, ROR1, TAGLN, MEF2A, DHODH, CENPE, NRG1, ID2, SP3, ID3, MAP2K1, TEK, FKBP4, DST, GSTM4, HHEX, CREM, TGFBR3, CENPC, RELA, KRT17, TLE1, GLO1, YWHAH, ICA1, PTK2, EEF1A2, PRKCD, PTPN11, EXOSC9, AOX1, MEF2C, SULT2A1, RING1, RAD51, FMR1, PRDX1, SOX4, RPL18, C1QBP, TJP1, ZFP36L1, BAX, MCL1, TNK2, SRSF1, FOXM1, PPP3CA, CRYZ, PPID, SSRP1, CAMSAP2, NSUN2, NCBP1, EP300, AHNAK, DNAH14, FAAP100, BST2, SREBF2, ARHGEF5, FOXO1, TWF1, AKAP13, TROAP, CDC20, GRSF1, MERTK, DPYD, HYAL2, ILF2, ILF3, FOXC1, DLG1, TAF10, MYO1E, PTP4A2, BNIP3, HSPB3, MLLT11, ARHGAP5, AKAP6, STK4, COASY, TRAF1, PLA2G7, CHAF1B, MTAP, CALCOCO2, EIF2B5, BAMBI, TARDBP, FADD, MAP2K5, MAPK7, PAK2, CBLB, DUSP8, DNAJC3, SRSF5, G3BP1, CLN3, NMI, SKP2, GRB10, MTA1, ITGB3BP, PPIL2, PDCL, MAPK8IP2, UBE2V1, DYNC1I2, ORC1, ILK, IKZF1, SNTA1, SNTB2, PPIG, TCOF1, GOLGA4, MYO9B, NFATC2, SMAD4, BIRC3, MTM1, SQSTM1, TUBB3, PPP1R1A, EIF4EBP1, EIF4EBP2, RIPK1, HDAC1, CAMK2D, DCTN2, PKD2, NAE1, DGKZ, IQGAP2, SNX1, MTMR1, MTMR2, CUL4B, TP53BP2, FHL1, ACVR2B, TUBA3C, RUNX3, NACA, BLMH, EXOSC2, BMPR2, SNTB1, TUBB2A, KLF9, C1D, CACNA1C, RUNX2, CDK13, CIRBP, CAMK1, COTL1, COX17, TOB2, DAG1, BOP1, EIF3A, POLA2, ZMYM3, DCTN1, NPAT, EIF2B1, MAP7, CTTN, TRIM25, FLNC, GAS6, CAPRIN1, GRB14, HES1, SLBP, NFE2L1, NEDD9, ITPR3, ZNF268, RASA3, PLS1, ESPL1, KANK1, SMC1A, GINS1, LPIN1, RFTN1, CASP8, NAA30, KIF22, MEF2D, CHD4, STARD3, PTGR1, NFATC4, ZNF638, KPNB1, CUL7, NAA25, KIAA0101, EMC2, FAM175B, SEPT2, SART3, NCAPD2, HERC3, JOSD1, KARS, EEA1, PAFAH1B3, PLCL1, PRKD1, PCM1, PPP2R5A, PPP2R5B, PTGES3, STK38, PPP2R4, QPRT, RASA2, RNPS1, ANKRD1, RPS6KA2, PCBP1, UBE3C, MTFR1, DLGAP5, CNN3, RPS6KA1, PPP1R7, NR0B2, STIL, RGN, SPA17, MAPRE2, NCOA2, DIXDC1, TRADD, TRIP10, TRIP6, MAPRE1, TSC22D1, ELAVL1, KISS1, MYLK, TAB1, NPY5R, NCOA1, SMAD2, SMAD1, UBE2V2, STK11, CCDC85B, ADIRF, EZH2, ZFHX3, ZIC1, ZYX, HSPB2, SEPT7, ADRM1, CCDC6, UAP1, PDCD2, PKN1, PKN2, MAPK14, CDC37, SGCB, CCNG2, NREP, DBN1, FSCN1, HIF1A, IFI16, CDKN3, ZSCAN26, DECR1, KYNU, UBE2S, HIST2H2BE, PTPN21, DUSP6, HADH, AOC3, TPD52L1, CPEB4, CSPP1, FAM110C, MICA, AAK1, KIZ, ERCC6L, RALGAPA2, QRICH1, LRRFIP1, FAM161A, NBPF1, MAP7D1, CHD9, WDR72, TTLL9, RABL6, GLYR1, ZBED5, COX19, LARP7, FILIP1L, ARID4B, FLYWCH1, C4orf46, RFTN2, FAM98B, ARHGAP29, SBK1, PDCD4, NCBP3, IFI44L, PHLDA2, PLEKHO1, C1QTNF9B-AS1, DCAF6, SGOL1, HERC4, BCORL1, TECRL, MDH1B, METTL10, RALGPS1, HABP4, DGKK, WIPI1, SAMD4B, TBCEL, CEP170, FNBP1L, HIVEP3, ARMC4, UBR4, STXBP5, KIAA1217, CAMSAP1, KANK4, CPSF3L, DCAF8, RSPH4A, THEMIS2, STPG1, FAM72A, CROCC, MEX3C, HECTD2, ATF7IP2, RIF1, STRIP1, CDC42BPA, CFAP126, PDE4DIP, IRAK1BP1, FAM208B, ZCCHC6, MBNL2, LRRC16A, KANK2, KAZN, KCTD11, CDCA2, IQSEC1, SFRP4, ZFAND6, OTUD7B, RALGAPA1, THOC7, NADSYN1, TWF2, DESI1, JADE1, PPP4R3A, SPOPL, NAPEPLD, FAM72D, RGS7BP, TENM4, PTRF, MAST2, PNCK, C16orf46, KLC3, LRRC8B, CNKSR3, RFWD3, PPIP5K1, PSRC1, SHQ1, KLHDC10, FBXO38, BRAT1, ZC3H14, LARP1, AGTRAP, SARM1, NHS, KLHL24, ANKRD12, ANKRD11, AFTPH, CRTC3, PARM1, C6orf89, DRAM2, ATF7IP, MPRIP, RAB11FIP1, NSMF, DSTYK, RNF19B, BNC2, CCDC81, RNF111, CCDC141, DNAH12, FAM83H, RBPMS2, FAM65A, GK5, RNF165, UBR3, FAM101A, CEP128, FGD6, PHLPP2, SYDE1, NEK10, VPS13C, RAPH1, USP45, NOL8, SSH2, RUFY3, SV2A, BZW1, ASRGL1, DHX30, MCM10, COPS6, MAEA, EPM2AIP1, DHX32, SH3BP5L, ARC, CXXC5, PID1, NRK, SETX, NOTCH2NL, ZFYVE16, PIWIL4, TMC6, NUFIP2, RNF144B, COMMD6, HAUS6, WAPL, PODN, IRF2BP2, CPEB2, BCDIN3D, KCTD20, SPRED1, SRGAP1, NECAB2, FGD2, PNPLA5, HUWE1, PXK, CENPV, S100A7A, NEK8, PHLDB2, ZBTB33, NBPF11, PEG10, PRUNE, PABPN1, MTDH, MAGI2, RTN4RL1, USP48, CASZ1, VASH2, LRRTM4, CAND1, HOOK3, JAZF1, SPATA24, OSTM1, RASSF3, NLRC5, CHD1L, GPBP1, TRIM69, RPS19BP1, RALGPS2, CARM1, FAM72B, COMMD2, METTL23, C19orf68, GAS2L3, DGKH, CEP57, RNF130, SPATS2, DNAAF5, KIF18B, PDSS2, THNSL2, TDRP, C2CD5, MIB1, CAMK1D, ERC1, MINA, RBM45, ZDHHC17, CRLF3, SIAH1, CREBRF, AEBP1, LRRC49, HID1, PLEKHH2, DNAH10, MAP4K3, CCDC50, CCDC103, TEX14, FAM114A1, MGA, UBR1, CHERP, WWC1, DHX40, SKA3, SIRT2, BAP18, KLHL7, DDIAS, CMIP, DHX37, YAF2, AMOTL1, EFCAB13, CKAP2L, TRIM22, THNSL1, C6orf165, CMTR2, CFAP46, ANKRD13A, ZBED8, PHACTR4, KMT2E, SCYL3, XRN1, ASPM, CMTM8, RDH10, SPG20, CNTROB, EID3, ADSSL1, CCAR2, CRIPAK, CFAP52, AGGF1, MT1M, ARHGAP18, ASCC3, FAM19A2, MPP5, ZCCHC7, MINK1, AFAP1L2, TAB3, NKAP, FAM101B, NBPF15, COMMD1, DRAM1, RNF182, ARFGAP2, AOPEP, ZNF655, KLHDC1, C7orf31, KIAA1958, ENAH, ABTB2, CNEP1R1, JMY, MFSD2A, PCSK9, HSD17B11, SERBP1, HJURP, NFATC2IP, BBOF1, LRRC16B, LSM14A, PAPD5, RCBTB1, RGS22, CPEB3, ABCF1, PLPP5, GSTCD, DUSP18, NGDN, MCPH1, SHCBP1, APPL2, NAV1, VPS37A, ZNF397, USP32, ARID1B, FLCN, REPS2, NUDT10, DBF4B, SEMA6D, CASC5, LILRB1, CEP70, CTCFL, KIF18A, RP9, PPP1R14C, RHEBL1, MPLKIP, PUM2, SETD6, TBC1D15, SPATA18, FAM110B, IFI44, NT5C, KIAA1524, PNPT1, URGCP, BICD2, NEK9, DLG5, STK35, LRRC8C, NEK7, RB1CC1, MICAL1, DNAH5, SSH3, UTP15, GEMIN5, IPO4, PNISR, FNIP1, UBASH3B, SHROOM3, GSG2, ABHD5, ZC3H15, PPIL4, PPP1R13L, HDAC7, CEMIP, PDCD6IP, PRUNE2, BLNK, TRIM41, CHTF18, N6AMT2, NUDCD2, TNFAIP8L1, ZFPM2, CKAP2, ATXN2L, ARAP3, IPCEF1, STAB2, RASSF5, PALLD, METTL21A, GEMIN6, PSPC1, GPR98, SYNE2, DNAJC9, BBX, NANOS1, ARNTL2, RIN2, RFFL, AQP3, SEC14L1, TRIB2, SNX19, TOPBP1, ELMO1, BAP1, NDRG1, HSPH1, LPGAT1, GCN1, NUP205, APPBP2, ANKS1A, SGCD, DYRK2, NSMAF, ANP32B, TFG, TNR, HDAC2, PROX1, CREBBP, SYMPK, TAF15, HAS2, TANK, APBB2, HPS1, FGF13, ARHGEF2, EMG1, GLMN, ATP6V0A1, LPP, RBPMS, HIST1H2BH, PTP4A1, PRKCDBP, RFK, FBXO32, UBE2E3, FBXW5, TEKT1, FAM162A, TP53INP1, EXOC4, KIAA1191, PNPLA2, TTC17, NABP1, ACD, MIB2, EME1, ISG20, UBE2W, DACT3, EXOSC8, SLC22A18, ARL8A, TADA1, CHCHD1, MOAP1, FAM136A, ARMC5, SYTL4, PPP1R14B, CTHRC1, HAUS1, OPTN, TUBGCP3, GPRASP2, TMCO6, NUDT16, ANAPC16, MSI2, SNRNP40, DNAH11, ELP4, MALSU1, DAZAP1, WDR34, MVB12A, CYFIP2, SAT2, NRBF2, CDCA5, CPNE2, DTD2, S100A16, IFT43, OTUB1, DPH3, CFAP36, NUDT11, RMND5B, ZNF274, CDCA7L, C5orf30, TCTN2, MASTL, MYO19, TONSL, PRR11, DOCK6, NAF1, FBXL20, BOD1, ABHD14B, PAWR, RSRC1, ITCH, VCPIP1, CHAMP1, FEM1C, ZFYVE19, RITA1, SCYL1, FAM84B, ZFR, SGCZ, C9orf72, RMDN2, FGD4, DRC1, PCMTD1, GLT1D1, CMTM3, NOL4L, VSTM2L, ZNF578, ZNF641, SPATA13, FRMD6, C8orf37, ASB16, SLC46A1, ANKRD27, CLIC6, IPO9, NECAB3, INPP4A, ERMAP, KLHL5, NEDD4L, QKI, SYNGAP1, FAM193B, NEK1, PLIN4, BTBD9, SMG1, KIF20B, DLC1, MTMR9, ALPK1, HHIP, MAGI1, SPAG5, PANX2, PASK, CITED4, MED15, ERGIC2, NUDCD1, USP28, TRIB1, RANBP9, SRPK1, STRBP, ATOH8, CEP89, OSBPL9, FAM129B, TCF12, MYCBP, CDC5L, PFDN5, GPER1, MPHOSPH8, MPHOSPH9, PKP4, TSC22D3, S100A13, TTC1, DNAJC7, C12orf57, PHB2, COPS8, RAD9A, CHP1, FEZ1, PITX2, LYST, DOK1, MTR, HSD17B10, SMAD5, BARD1, HNRNPAB, LITAF, NAP1L4, CDC6, MDFI, CIB1, CCT7, ARID3A, HAUS7, PRMT1, DUSP9, CITED1, TEP1, VRK1, GDF15, NCAPG, HOPX, PAIP2, MAPKAP1, NABP2, MYBBP1A, AIF1L, SLF1, DBNDD2, CORO1B, CPPED1, SDF4, PDCD2L, AIFM2, LARP6, GINS4, PELO, FAM213A, LXN, FAM64A, MARVELD1, FEM1A, CCM2, INPP5K, DIDO1, IER2, LRRC1, TBCD, NDC1, MKNK1, TUBB6, PDCD10, MENT, HTATIP2, BDH2, FAM195A, THUMPD3, DUSP26, ADI1, RNF126, SNRNP25, KATNB1, TUBB2B, MLST8, TRIM62, PHF20, DUSP23, TIPIN, KATNAL1, ACAT2, RBM4, CDCA7, PAPOLG, CARD10, RBM24, SORBS1, OSBPL10, NAA15, PINK1, CLEC7A, NUSAP1, TEX15, OSBPL1A, FANCD2, BEX2, PACSIN1, SCAPER, HDAC8, POLDIP3, DUSP16, FUT8, SPRR2G, NIFK, PARD6B, TRIM34, YTHDF1, WNK3, BACH2, PANK2, UACA, WDR11, CRNKL1, PRKD2, FAM129A, TRIM8, FOXP3, UBXN6, SPRY4, TRIM9, TRIM6, TRIM4, TRIM2, INO80B, LRRCC1, UNK, ZCCHC2, XPO4, CEP44, ZNF436, KLHL4, STRADB, ACTR6, SENP6, NIF3L1, NAA50, UBA5, PAIP1, NBPF3, IQCG, COMMD4, TOLLIP, RNF38, RACGAP1, CCDC113, SIK2, WWP1, CCDC8, BCL11A, SDCBP2, NUCKS1, UPF3A, SPTBN4, SH3BGRL3, TRIOBP, TSPYL2, BLZF1, PDCL3, TNKS2, TAOK3, RAB3GAP2, DHX36, HIPK2, EPB41L4B, PABPC3, KCTD10, TXNIP, DSN1, CHMP4B, FBXL15, WNK1, TUBB1, FAM83D, SENP3, PLEKHA4, RGCC, GSTO2, DUSP21, FAM96A, DHX35, BICC1, ARMC7, AZI2, EGLN3, LRRC19, ASB8, SMYD3, DOCK5, WDR26, SUDS3, AUNIP, METTL8, UBE2Z, RMND5A, CSRP2BP, METTL7A, ZNF395, AKTIP, ECT2, REEP1, HN1L, PANK3, CHODL, COPS7B, ELP3, LIN28A, MEAF6, PLEKHA5, SMURF2, UPF2, PLEKHA2, CACYBP, RRAGC, RC3H2, IFT122, BEX1, MKNK2, AS3MT, TNS1, VEZT, ETNK1, APOBEC3G, EML4, NEK6, EPG5, ARHGEF10L, CWC22, SYTL2, RAVER2, AGO4, CSNK1G1, EPB41L4A, CD248, SRA1, GOPC, SEPSECS, RANGRF, MYO10, CD209, SLC40A1, ARFGAP3, SSU72, PARD6A, EXOSC4, UBE2T, SPAG4, ADAP2, ACP6, BRD7, PLCB1, CASS4, HEYL, TCF7L2, IFT46, HINT3, HPS4, RRAGD, PFDN4, KMT5A, EXOSC3, KIF13B, GPHN, PDLIM7, ACSS2, ASH1L, EIF2B3, MBNL1, CYP26B1, SLC2A4RG, PDGFC, EIF4ENIF1, TULP4, STRN4, IL17RB, LATS2, CDC42SE2, UBQLN4, CDC42SE1, SNX15, DUSP22, RASSF1, KCNIP2, RPRM, RAD18, HOMER3, BRWD1, PNPLA3, NRBP2, SMC4, MDN1, MBNL3, DDX28, LIN7C, SPATS2L, UFSP2, TDP1, DCAF13, RNF19A, EXOC1, NDFIP2, FANCI, ARL8B, GNL3L, DNAAF2, TBCCD1, ARMC1, RLIM, HAUS2, KBTBD4, RBM22, RBFOX1, PARPBP, HCFC1R1, GEMIN8, TRNAU1AP, DDIT4, HYPK, MKS1, ING3, AATF, SPHK1, ABI2, DNAH9, DACT1, BCLAF1, ZAK, MIS18A, NKIRAS1, PLEK2, PLK2, STMN3, FAM120A, IL37, GRHL1, DTL, ITSN2, EHD3, FLRT3, FLRT1, LMCD1, DSPP, THYN1, CRIPT, HACD3, NDUFA13, MARK1, SH3BP4, SPATA7, CAMSAP3, SLAIN2, FNIP2, PAK7, CTTNBP2NL, DNAH1, MYEF2, KLHL42, WDR35, HECW2, STARD9, FRMD4A, IMPACT, ATXN10, DNMT3B, SPRR3, PI4KB, HECA, UXT, ARPP21, HDAC6, SPAST, VPS29, EIF3K, GRHPR, DNAJB9, GABBR1, RNF14, ZMYM2, TJP2, DNAJB4, VTI1B, ADD3, PLEKHB1, LRWD1, MIOX, SLC23A2, ZRANB1, TES, KDM5B, DMBT1, PARP2, LIMD1, MLX, LIMA1, ASIC3, TBK1, DCDC2, SLC7A8, DDX20, ADAMTS1, SHPK, USP25, BAIAP2L1, EVL, EIF2B4, DACH1, DNAI1, TEKT2, SERPINB13, PLXNA1, ZMYM5, MOSPD1, ERRFI1, TUBD1, FBXL7, NOCT, FEM1B, FBXO10, FBXO9, FBXL2, TNIK, PITPNC1, CDC42EP3, NXT1, FBXO5, HDAC9, AGO2, ELF5, NUP50, BLOC1S6, TAOK2, RAB23, INTU, RIMKLB, ZMIZ1, NDRG4, PPM1H, CORO1C, TP53TG3, PYCARD, MYO6, NFU1, PRPF19, PHTF1, SUFU, BOK, SYNRG, NDRG2, G3BP2, RPH3AL, STUB1, CDC14A, SNX6, GTF2A1L, DIMT1, TTF2, NSFL1C, MACF1, PPP6R1, AGAP1, TRIM35, PLCL2, SMG5, MAPK8IP3, TRAK1, AGTPBP1, DICER1, MAPRE3, PA2G4, EXO1, CDK11A, SMC3, MAPK8IP1, HDAC5, TRPC6, NIP7, GNE, RUVBL2, AKT3, POMP, LZTS1, RNF6, POLH, RUVBL1, TNFSF13B, INVS, FARSA, DRG1, PKIG, STK38L, EPB41L3, SIK3, FRMD4B, FAN1, PTPN22, CRYL1, GIT1, SH3GLB1, ZDHHC9, RRP7A, SBDS, TPRKB, FAM96B, RTCB, TSC22D4, NOC2L, RPL36, KNSTRN, ZNF175, MTF2, TLN1, NFE2L3, DAAM1, WDR7, USP15, FARP1, FAM65B, GPSM3, MYO5A, DTNA, MAP4K5, WIPI2, LAS1L, ARIH1, CSDC2, ASB3, YTHDF2, HEY1, PCYT1B, TNPO3, SRPRB, GMPPB, CDC42BPB, RBM8A, ZNF706, SNX9, HEBP2, HCFC2, FHOD1, IRAK3, PSAT1, CPQ, TACC3, EID1, MAD1L1, STK24, BZW2, COMMD10, SNCAIP, CABIN1, IGF2BP2, CSNK1G3, SLC30A1, SESN1, STON1, NCOA3, MAP3K4, DUSP10, IVNS1ABP, CAMTA1, LOC440434

GO:0005739

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mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

VWA8, GTPBP10, NUDT19, AGPS, ACOT7, HAX1, EYA2, NDUFS8, CLIC1, NDUFA4, NME4, ACACB, ACOT8, TPP1, TIMM23, UQCRQ, RAB29, SLC27A2, GNPAT, NDUFA1, ACOX3, SPTLC2, FANCG, OGT, CD3EAP, CYP27B1, NDUFS4, ADAM12, AKR7A2, RAD51C, BCL2L11, FOXO3, AKAP10, GSTZ1, TRIAP1, GATC, SLC25A17, C21orf2, IDH3B, BNIP3L, SH3BP5, PARK2, TRAK2, OPA1, KIF1B, FADS1, PPL, MRPS14, DIAPH2, NOL3, PTCD1, ATG13, LRP5, NDUFS2, MPDU1, NME6, ERN1, ECI2, LYPLA1, TRMU, SLC25A12, PPP1R15A, IDH1, GATB, ALDH1L1, TUSC2, ATP5H, ATP5L, CLPX, DDAH1, URI1, PROSC, GLS, NDUFB6, MFN2, NDUFB4, NDUFA7, ZNF205, LETM1, SLC25A14, FARS2, ETHE1, AIFM1, DDAH2, TOMM40, CYB5R3, GOT2, KRAS, GNRH1, CRYAB, SOD2, TP53, CYP1A1, TYMS, CYBB, CYP17A1, CYP11A1, SLC25A5, MPO, CYP2E1, FYN, CDK1, TH, LDHB, GPX1, PSAP, CTSB, UQCRH, FH, ANXA6, HSP90AB1, MMP2, PDHA1, CYC1, GSTP1, QDPR, DLD, COX6C, PARP1, ALDOC, PET100, HSPA1A, HSPA1B, FDX1, BCL2, DLAT, TXN, COX5B, MGST1, CYP2D6, HSPD1, CLU, HSPA5, PDHB, DBT, PC, MTHFD1, NEFH, HARS, SLC25A4, CKB, CKMT1A, BCKDHA, P4HA1, MTHFD2, HCLS1, PKM, IDE, COX6B1, CYP11B1, HIVEP1, ARSB, COX7C, PRKCA, GJA1, CKMT2, NDUFB7, PRKACA, GM2A, RPL35A, LIG1, ATP5J, CYP11B2, HK1, NDUFV2, ELK1, NFKB1, MAOA, SDHB, BCKDHB, COMT, TGM2, SCP2, UBA1, UQCRC2, ME2, GCSH, DTYMK, COX7B, MPST, UCP1, PLN, STOM, AK4, MAOB, MAPK3, G0S2, NDUFS1, MAPK1, LAP3, CASP1, ATP5D, ECHS1, PPP2R1A, TSPO, ADSL, SRI, ALDH1B1, SDHA, DNAJA1, AKT1, UQCRC1, YWHAB, SFN, GK, ACSL1, DUT, SHMT1, PHB, BSG, GLRX, HMGCL, MAP2K2, ATP5C1, CPOX, NUDT1, PPP1CC, GPX4, SNCA, MPV17, FEN1, IFI27, MDH1, MDH2, RGS2, ELK3, ECI1, LRPPRC, CRAT, TSFM, VDAC2, ACADSB, MAPK8, MAPK9, UQCRFS1, ATP5O, IDH2, RPL34, FASN, ALDH7A1, GLUD2, HARS2, CASP4, STAR, PSMB3, ACADVL, PSEN1, FHIT, RANBP2, GSK3B, CPT1A, CDK7, DAP3, BCAP31, HSD17B4, RAP1GDS1, HRSP12, MRPL12, SUCLG1, HCCS, POLG, RARS, BCAT1, ALDH18A1, HADHB, CASP9, GFER, OXCT1, UCP3, BID, NDUFV3, CMC4, MTCP1, ATP5I, SYNJ2BP, SESN2, YBEY, NLRP5, PTEN, ROMO1, ABCE1, HSPE1, STXBP1, RPS15A, YWHAE, RPS14, RAB11A, YWHAZ, DYNLL1, GNG5, RACK1, NTHL1, ABAT, MRPS25, MRPS10, MRPS5, MRPS36, MRPS34, CYCS, TFAM, SLC25A3, PLIN5, E2F1, DHODH, OGDH, ALDH6A1, MAP2K1, FKBP4, SSBP1, YWHAH, PTPN11, RAD51, PRDX1, SOX4, C1QBP, BAX, MCL1, PPP3CA, NCBP1, PMPCA, FOXO1, GRSF1, ILF3, BNIP3, ECH1, PRDX4, CLN3, TCIRG1, RIPK1, TP53BP2, RAB32, ALKBH1, PMAIP1, AUH, COX17, TFDP1, ICT1, NBR1, KCNJ11, CASP8, STARD3, EMC2, LARS2, KARS, POLD3, ACOX1, PDK1, ERBB4, TOMM20, MTFR1, STK11, RAB11B, CRY1, MAPK14, MRPL23, DPYSL2, FXN, PDK4, CYP1B1, DECR1, KYNU, CLPP, ME3, PCK2, HADH, DGUOK, TXNRD1, SPHKAP, PGS1, ALDH1L2, TIMM50, NADK2, CCDC58, HS1BP3, CMPK2, EARS2, PITRM1, COX20, SLC25A30, THEM4, ERCC6L2, ATPAF1, FAM72A, MARC1, KANK2, TTC19, XAF1, MRM1, HIBCH, PTRF, RPUSD3, MRPL14, MTFR2, TMEM65, SARM1, MTHFD1L, OLFM4, APOOL, HSDL2, SLC25A26, DHX30, PARS2, ENOSF1, DHX32, MAVS, DHX29, HDDC2, MAATS1, CMC1, USP48, NT5DC3, NDUFA11, ECHDC2, PPARGC1B, TMTC1, ADHFE1, MSRB3, MRPL41, SUPV3L1, THNSL1, MICU2, CLYBL, NDUFAF2, ARMC10, PPM1K, TCAIM, PRSS35, GTPBP8, GUF1, PNKD, TOMM5, ZADH2, OXR1, ATAD1, UXS1, ZMIZ2, ABHD11, PPTC7, GADD45GIP1, NUBPL, TBC1D15, FAM110B, MRPL30, NT5C, PNPT1, MGARP, RHBDD1, COX7B2, PTPMT1, NUDT8, DCAKD, SLC44A1, PALLD, SYNE2, BRI3BP, PPM1E, CHCHD10, CPT1B, GBF1, MRPS31, AKAP1, ESR2, RAB8B, BAD, RFK, GTPBP3, TBRG4, FAM162A, CHCHD1, MOAP1, MIEF2, RPUSD4, SLC25A36, AP2M1, DNAJC19, RMDN1, ECHDC3, MTFMT, STARD4, LGALS12, MALSU1, PTCD3, PERP, C7orf55, COX14, APOPT1, DCAF5, PACRG, DGAT2, TRNT1, TEFM, GFM1, MCCC1, SECISBP2, NMNAT3, YME1L1, MYCBP, ACOX2, MTERF1, TIMM17A, PHB2, SDHC, FEZ1, HSD17B10, TXN2, MIPEP, ACO2, CCT7, NIPSNAP1, ELAC2, MACROD1, MGME1, AIFM2, UQCC2, FAM213A, AGMAT, TACO1, DHRS4, APOO, ABHD6, DUSP26, MECR, NUDT9, ACAT2, FUNDC2, SFXN3, HINT2, BBC3, PINK1, MRPL1, MRPS26, PANK2, MRPL37, UACA, MAP1LC3B, SLIRP, CCDC90B, NIF3L1, QRSL1, GABARAPL1, RAB1B, MTIF3, C12orf65, ACBD3, PIF1, ACSS3, METTL17, MTHFD2L, SFXN1, GRPEL1, AS3MT, PLGRKT, CAPN10, MCCC2, TRIM39, MRS2, MRPL47, ABCB6, NGB, ACP6, NOX4, ACOT13, TIMMDC1, MRPL40, XPNPEP3, PFDN4, STARD7, CTPS2, GLRX2, TOMM22, DEPP, LYRM2, ABHD10, DDX28, NDFIP2, ATAD3A, GNL3L, ARMC1, MTPAP, ATP5SL, ARGLU1, C14orf119, AURKAIP1, DDIT4, NDUFB11, OCIAD1, SYBU, HAO2, CISD1, MRPL35, COQ3, MAT2B, DNAJC27, MRPL15, NDUFAF4, HACD3, NDUFA13, TOMM7, PAK7, SUCLA2, AASS, MUTYH, AK3, ANXA10, CRLS1, SLC25A13, CROT, SARDH, BAG5, MTUS1, NDRG4, MAFF, PYCARD, NFU1, BOK, NOL7, TRAK1, AGTPBP1, PRELID1, BCS1L, VDAC3, HIF3A, MRPS28, COA3, POLDIP2, ACOT9, MRPS2, COQ4, REXO2, BOLA1, FAM65B, SAMM50, GMPPB, HEBP2, MRPS18B, MRPL42, CHCHD2, COX11

GO:0005740

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mitochondrial envelope

The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.

MAOB, HADHB, ABCB6, ADAP2, ABCF2

GO:0005741

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mitochondrial outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

HAX1, DDX3X, ACACB, KMO, CYP27B1, CYB5B, BCL2L11, BNIP3L, OPA1, ACSL4, PPP1R15A, MFN2, TOMM40, CYB5A, CYB5R3, ASS1, RAF1, PGR, CNP, BCL2, MGST1, NME1, GJA1, HK1, MAOA, MT3, MAOB, TSPO, GK, ACSL1, PPP1CC, IFI27, VDAC2, ATP5G3, SLC11A2, CPT1A, EPHA4, HADHB, BID, ATP5G2, BAX, MCL1, BNIP3, COASY, RAB32, PMAIP1, LPIN1, CASP8, TOMM20, MARC1, LETMD1, VPS13C, MAVS, SPG20, TOMM5, CISD2, FAM73A, SPATA18, SLC44A1, RTN4IP1, BRI3BP, CPT1B, AKAP1, BCL2L2, BAD, MOAP1, MIEF2, MYO19, PHB2, AIFM2, PINK1, MFF, GPAM, ABCB6, TOMM22, CISD1, TOMM7, PI4KB, ACSL6, BOK, VDAC3, SH3GLB1, SAMM50

GO:0005742

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mitochondrial outer membrane translocase complex

A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments.

TOMM40, TOMM20, TOMM5, PINK1, TOMM22, TOMM7

GO:0005743

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mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

UQCRHL, NDUFA4, NME4, NDUFAB1, TIMM23, UQCRQ, UQCR11, KMO, MRPS12, NDUFA1, NDUFS4, PRODH, NDUFA2, OPA1, MRPS14, TIMM17B, NDUFS6, MRPL33, SLC25A12, ATP5H, ATP5L, CLPX, ABCA8, NDUFB6, NDUFB4, NDUFB8, NDUFA7, LETM1, SLC25A14, NDUFA10, CDS2, AIFM1, NDUFB10, CYB5R3, GOT2, TYMS, CYP11A1, SLC25A5, UQCRH, CYC1, CNP, COX6C, FGR, COX5B, MGST1, HSPD1, COX6A1, SLC25A4, CKMT1A, HSD3B1, COX6B1, UQCRB, CYP11B1, COX7C, SLC25A16, CKMT2, NDUFB7, LGALS3, ATP5J, CYP11B2, NDUFV2, COX5A, SDHB, UQCRC2, COX7B, UCP1, HSD3B2, MAOB, ABCD3, ATP5D, SDHA, PRKAR2B, UQCRC1, PHB, HMGCL, ATP5C1, CPOX, MPV17, STAT3, MDH2, ECI1, CRAT, GPD2, VDAC2, PLA2G4A, UQCRFS1, ATP5O, IDH2, MRPL19, ACADVL, PSEN1, CPT1A, GATM, DAP3, ALDH3A2, MRPL12, SLC25A1, SUCLG1, HCCS, ALDH18A1, HADHB, UCP2, UCP3, NDUFV3, ATP5I, ROMO1, MRPS25, MRPS10, MRPS5, MRPS36, MRPS21, MRPS34, CYCS, SLC25A3, DHODH, PMPCA, ICT1, MRPL23, PDK4, NDUFA5, HADH, LETM2, PGS1, NDUFAF6, TIMM50, MRPL51, OCIAD2, SLC25A30, THEM4, ATAD3B, NDUFAF5, MARC1, TTC19, MRPL54, MRPL14, LETMD1, SFXN4, SLC25A26, MRPL21, MRPL55, MRPL52, NDUFA11, MRPL41, MICU2, NDUFAF2, GUF1, MRPL50, RDH13, DUSP18, MRPL30, PTPMT1, SLC25A43, MRPS31, CHCHD1, SLC25A36, DNAJC19, MRPL38, OMA1, PTCD3, MRPL48, SLC25A44, COQ2, DHRS1, MCCC1, YME1L1, TIMM17A, PHB2, SDHC, NIPSNAP1, MRPL34, UQCC2, MTG1, NDUFAF3, SLC25A23, PINK1, MRPL32, MRPL4, MRPL1, MRPS26, MRPL37, SLC25A39, SLC25A18, GHITM, MTG2, MTHFD2L, SFXN1, MRPL44, SLC25A19, GPAM, MRS2, MRPL47, ABCB6, TIMMDC1, MRPL40, ABCB10, MRPL17, TOMM22, ATAD3A, MRPS18A, AURKAIP1, NDUFB11, MRPL16, SLC25A37, MRPL35, COQ3, MRPL15, NDUFAF4, NDUFA13, MRPL36, SLC25A10, UQCR10, CRLS1, SLC25A13, BOK, HIGD1A, EXOG, GSTK1, MRPS28, COQ4, SAMM50, TIMM10B, DNAJC15, SLC25A15, MRPS18B, MRPL42, COX11

GO:0005744

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mitochondrial inner membrane presequence translocase complex

The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.

TIMM23, TIMM17B, TIMM50, TIMM17A, TIMM21

GO:0005746

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mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

UQCRH, UQCRB, COX7B, UQCRC1, COX7B2, NDUFA13

GO:0005747

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mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

NDUFS8, NDUFA4, NDUFAB1, NDUFA1, NDUFS4, NDUFA2, NDUFS2, NDUFS6, NDUFB6, NDUFB4, NDUFB8, NDUFA7, NDUFA10, NDUFB10, NDUFB7, NDUFV2, NDUFS1, SNCA, NDUFV3, NDUFA5, NDUFA11, NDUFB11, NDUFA13

GO:0005749

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mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.

SDHB, SDHA, SDHC

GO:0005750

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mitochondrial respiratory chain complex III

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.

PMPCB, UQCRB, UQCRC2, UQCRC1, UQCRFS1, UQCC3, UQCR10, BCS1L

GO:0005751

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mitochondrial respiratory chain complex IV

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).

NDUFA4, COX5B, COX6A1, COX5A, NMES1

GO:0005753

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mitochondrial proton-transporting ATP synthase complex

A proton-transporting ATP synthase complex found in the mitochondrial membrane.

ATP5H, ATP5L, ATP5J, ATP5D, PPIF, ATP5C1, ATP5O, ATP5G3, ATP5E, ATP5I, ATP5G2

GO:0005757

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mitochondrial permeability transition pore complex

A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).

BAX

GO:0005758

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mitochondrial intermembrane space

The region between the inner and outer lipid bilayers of the mitochondrial envelope.

HAX1, NME4, TIMM23, TRIAP1, OPA1, AIFM1, LYN, FGR, HSD3B1, COX6B1, NDUFB7, DTYMK, HSD3B2, NDUFS1, CPOX, STAR, GATM, SUOX, THOP1, GFER, CMC4, BLOC1S1, CYCS, COX17, COX19, THEM4, MICU2, PNPT1, CHCHD10, CEP89, UQCC2, CHCHD5, CHCHD7, PINK1, NLN, PANK2, TXNIP, SDHAF3, COA4, PRELID1, REXO2, TIMM10B, CHCHD2

GO:0005759

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mitochondrial matrix

The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

TK2, NDUFS8, NME4, NDUFAB1, KIAA0391, PRODH, IDH3B, PTCD1, NDUFS2, PMPCB, CLPX, GLS, NDUFA10, FARS2, ETHE1, GSR, GOT2, NR3C1, SOD2, TP53, TYMS, ALDH2, CYP11A1, PCCA, GPX1, FH, PDHA1, DLD, FDX1, DLAT, HSPD1, PDHB, DBT, PC, BCKDHA, MTHFD2, CREB1, AGXT, BCKDHB, ME2, GCSH, DTYMK, AK4, NDUFS1, ATP5D, ECHS1, PPIF, ALDH1B1, HIBADH, HSPA1L, HMGCL, ATP5C1, NUDT1, DLST, MDH2, ECI1, TSFM, ACADSB, IDH2, ALDH7A1, HARS2, ACADVL, MTHFS, SUOX, SUCLG1, ATXN3, OXCT1, ATP5E, ABCE1, HSPE1, BLOC1S1, ABAT, TFAM, OGDH, ALDH6A1, SSBP1, RNASEL, RAD51, C1QBP, MCL1, PMPCA, COASY, AUH, ICT1, FASTK, LARS2, KARS, PDK1, ERBB4, ETFDH, FXN, PDK4, DECR1, CLPP, HAGH, ME3, PCK2, HADH, DGUOK, TRMT5, ALDH1L2, ACSM3, LACTB2, EARS2, PITRM1, THEM4, PDSS1, IBA57, SDHAF4, HIBCH, FDX1L, MTHFD1L, PARS2, PDSS2, PHYKPL, MMAA, CARKD, ADHFE1, ETFBKMT, SUPV3L1, CCAR2, PPM1K, GUF1, GADD45GIP1, NUBPL, GPT2, MALSU1, MMAB, PRIMPOL, MCEE, TRNT1, TEFM, GFM1, MCCC1, PEO1, MTERF1, HSD17B10, TXN2, MIPEP, ACO2, ELAC2, UQCC2, MTG1, ALKBH7, ISCA1, NUDT9, PPA2, MTG2, DUSP21, MTHFD2L, GRPEL1, MCCC2, SDHAF3, GLRX2, ACSS1, ABHD10, COQ3, PDP1, SUCLA2, AASS, DMGDH, AK3, SARDH, DIMT1, LIPT1, PIN4, GSTK1, ACOT9, REXO2, PAM16

GO:0005760

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gamma DNA polymerase complex

A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA.

DNA2, POLG

GO:0005761

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mitochondrial ribosome

A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.

MRPS12, MRPS14, NDUFA7, MRPL51, GADD45GIP1, CHCHD1, MRPL48, MRPL34, MRPL57, MTG1, MRPL32, MRPL37, MTG2, MRPL40, MRPL35

GO:0005762

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mitochondrial large ribosomal subunit

The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).

MRPL33, MRPL19, MRPL12, ICT1, MRPL23, MRPL51, MRPL21, MRPL55, MRPL52, MRPL41, MRPL32, C12orf65, MRPL47, MRPL17, MRPL16, MRPL15, MRPL36

GO:0005763

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mitochondrial small ribosomal subunit

The smaller of the two subunits of a mitochondrial ribosome.

MRPS12, MRPS14, DAP3, MRPS5, MRPS36, MRPS21, MRPS31, MRPS26, MRPS18A, MRPS28, MRPS2, MRPS18B, MRPL42

GO:0005764

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lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

TMEM150B, RNASET2, TPP1, NPC1, STX7, RAMP3, VAMP4, CLN5, BCL10, ADA, ASS1, CST3, LDLR, IL1B, HLA-DRA, MPO, CTSD, ADRB2, PSAP, CTSL, CTSB, STS, CTSH, RNASE2, GAA, LAMP1, ACE, LAMP2, HLA-DOB, TYR, ARSA, ARSB, IFNAR1, GJA1, TNFAIP3, CTSS, PRDX6, USP6, SNCA, LIPA, CTSK, SLC11A1, TSC2, LRBA, PPT1, RAB7A, RAB9A, RAB27A, SGSH, ARSD, CTSC, NAGLU, GALC, SNX16, CXCR4, NPC2, LRP2, CTBS, CD164, HYAL2, ANK3, CHIT1, CLN3, LAPTM5, NBR1, TRIP10, TMEM97, MARCH8, LAMTOR1, RAB12, DRAM2, KIAA1324, TMEM150A, DRAM1, RNF152, PCSK9, SLC38A9, FLCN, ENGASE, TPCN2, WDR48, MARCH1, GLMP, ABCA5, GGH, HPS1, ARRDC3, C9orf72, CCDC115, ANKRD27, FNBP1, NEU1, SYT11, BBC3, TMEM59, AP5M1, RRAGC, ATP13A2, HPS4, RRAGD, TMEM9, CTSZ, CTSF, PCYOX1, EPDR1, PPT2, HPSE, AP3M1, MYO5A, CPQ

GO:0005765

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lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

TMEM150C, AP3D1, ABCD4, NPC1, STX7, TLR3, GPR137B, ATP6V1G1, CLN5, FLOT1, TMEM63A, SNAPIN, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, ANXA2, PSAP, ANXA6, HSP90AB1, GNAI3, GAA, LAMP1, IGF2R, COL6A1, LAMP2, CFTR, HLA-DRB4, HLA-DOB, ACPP, CD1D, HLA-DPA1, ATP6V1B2, ATP6V1C1, UBA1, ENPP1, DPP4, HLA-DMB, GNA11, CD68, TRIM23, ECE1, NSF, SLC11A2, PSEN1, GNAQ, RAB5C, RAB7A, CLCN5, CLCN6, CLCN7, VAMP7, AP1S2, RAB2A, ATP6V0D1, AP1S1, GNB1, GNB2, UBA52, GNAI1, BLOC1S1, HLA-DRB3, GPLD1, DAB2, LRP2, IFITM3, CD164, AHNAK, AP1B1, CLN3, PLD1, TCIRG1, LAPTM5, STARD3, RHEB, MMD, HLA-DRB5, MARCH8, ABCC10, HGSNAT, LAMTOR1, RAB12, TLDC1, DRAM2, KIAA1324, SLC36A1, TECPR1, SLC26A11, OSTM1, SLC44A2, DRAM1, SLC15A4, RNF152, SLC38A9, DAGLB, ATP6V1C2, MFSD8, TPCN2, MARCH1, SPPL3, SPPL2A, HM13, SCARB1, GLMP, ABCA5, TMBIM1, BORCS7, ARL8A, AP2M1, BORCS6, VPS35, NEU1, P2RX4, LITAF, TMEM59, OSBPL1A, WDR11, TM6SF1, AP5M1, TMEM165, TMEM8A, GOPC, ATP13A2, TMEM106B, LMBRD1, ARL8B, TMEM9, ANKFY1, VTI1B, LAMTOR3, ATP6V1H, LNPEP, MYO6, LAMP3, HPSE, LAMTOR2, AP3M1, ATP6V1D

GO:0005768

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endosome

A vacuole to which materials ingested by endocytosis are delivered.

DSCR3, ARPC2, LEPROT, STX7, RAB11FIP3, PDCD6, VPS4B, VAMP4, VPS26A, RASSF9, PAK3, FLOT1, MYO1D, EGFR, NGF, TFRC, ANXA1, NTRK1, APP, FYN, ANXA2, ADRB2, NGFR, STS, HMGB1, IGF2R, ACE, EZR, FOLR1, RAB5A, MAL, S1PR1, LHCGR, CDK2, AVPR2, CLIP1, GPC1, TGFBR1, ADCYAP1R1, PRKCI, NSG1, ECE1, CRKL, CDKN1B, ATP1A2, CLCN5, RAB5B, RHOA, TGFB2, GRB2, LRP2, CAV1, CD164, TNK2, STX4, PLD1, RAPGEF1, KCNJ11, RFTN1, RABEP1, PKN1, WDR72, OCIAD2, TJAP1, MARCH8, STEAP4, RAB11FIP2, ARC, RABEPK, DGKH, ARRDC4, EXPH5, MARCH1, FRS2, SNX33, SORL1, ARRDC3, SYTL4, C9orf72, CCDC115, VPS35, SNX18, TM9SF2, ZFYVE21, PACSIN1, CHMP4B, ABCB6, OCIAD1, BET1L, PI4KB, SPAST, VPS29, SCOC, RAB21, BLOC1S6, ANKRD50, SNX9

GO:0005769

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early endosome

A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.

WASH1, NEURL1B, RHOD, NRP1, RAB29, STX7, TLR3, SIAH2, STX6, TRAK2, SNX3, DIAPH2, ATP9A, VPS26A, LRP6, FLOT1, STAMBP, LDLR, CD4, APOA1, APOE, APOA2, APOC3, TF, APOB, NTRK1, ANXA2, ADRB2, ADRB1, HSPD1, IGF2R, CFTR, GJA1, VCAM1, RAB5A, F2R, MAPK3, MAPK1, EPHA3, CORO1A, AKT2, PHB, NF2, MAP2K2, SLC11A2, NUMB, RAB5C, CLCN3, F2RL1, SNX16, RAB5B, CXCR4, ATP6V0D1, RHOB, RAB1A, RAP1A, OCRL, MAP2K1, NUCB1, PTP4A2, CLN3, RAB31, RAB32, RAPGEF1, EEA1, RABEP1, AOC3, HFE, CCDC93, RABGAP1L, LDLRAP1, WLS, PARM1, ZFYVE16, SIAH1, VPS8, COMMD1, NIPA2, PCSK9, ARRDC4, DNER, RIN3, TBC1D16, SORL1, PTP4A1, MIB2, ARRDC3, SGK3, ANKRD27, ALS2, VPS35, GPER1, KIFC1, DERL2, ACKR4, ANKFY1, VPS29, RABGEF1, RAB22A, SNX12, TRAK1, LAMP3, ATP11B, NISCH, CCDC53, MYO5A, LIPG, WASF2

GO:0005770

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late endosome

A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.

WASH1, STX7, SLC31A1, SLC31A2, LDLR, TF, NTRK1, LAMP1, IGF2R, LAMP2, IFNAR1, F2R, MAPK3, MAPK1, DDIT3, MAP2K2, HTT, SLC11A1, RAB7A, RAB9A, RAB27A, CLCN3, SNX16, CXCR4, RAP1A, ARF1, MAP2K1, CLN3, MTM1, SQSTM1, NBR1, PARM1, KIAA1324, MAGI2, ANKRD13A, PCSK9, SLC38A9, PIK3C3, WDR48, SPPL2A, RNF128, ABCA5, SLC9A6, ANKRD27, VPS35, PIK3R4, SDF4, TMEM59, OSBPL1A, DERL2, AP5M1, MAP1LC3A, ATP13A2, TMEM9, VPS29, RAB22A, KIDINS220, LAMTOR2, MYO5A

GO:0005771

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multivesicular body

A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.

CST3, CD74, LAMP1, TPT1, SLC2A4, GJA1, ZP3, RAB11A, BST2, SLC40A1, ATP13A2, HDAC6

GO:0005773

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vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

CD74, SLC11A2, STX4, NPRL3, STX3, GLB1L2, GGH

GO:0005774

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vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

RAB7A, NAPB, TMEM138, PCYOX1

GO:0005776

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autophagosome

A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.

WASH1, TBC1D12, ULK1, IL1B, RALB, HTT, GABARAPL2, PIP4K2B, CALCOCO2, CLN3, SQSTM1, NBR1, RAB12, TP53INP2, TBC1D5, TP53INP1, OPTN, NRBF2, C9orf72, PIK3R4, MAP1LC3B, PEG3, GABARAPL1, MAP1LC3A, ZFYVE1, ATP13A2, UBQLN4, TBC1D14, RAB23

GO:0005777

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peroxisome

A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

AGPS, PEX12, ABCD4, GNPAT, ACOX3, SLC25A17, PEX14, IDH1, TRIM37, PEX11B, VIM, NUDT7, IDE, AGXT, SCP2, ABCD3, TKT, HMGCL, MPV17, CRAT, XDH, IDH2, HSD17B4, HRSP12, PEX3, ECH1, IDI1, ACOX1, ACBD5, HSDL2, TMEM135, LONP2, ZADH2, ACOT4, GBF1, FAR2, ACOX2, DHRS4, IDI2, MFF, PNPLA8, HAO2, PIPOX, AKAP11, CROT, GSTK1, KIAA0430, MYO5A

GO:0005778

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peroxisomal membrane

The lipid bilayer surrounding a peroxisome.

AGPS, PEX12, ABCD4, SLC27A2, GNPAT, SLC25A17, ACSL4, PEX14, PEX11B, HMGCR, MGST1, ABCD3, ACSL1, MAP2K2, ALDH3A2, HSD17B4, PEX3, ARF1, ACOX1, TMEM35, ACBD5, MAVS, ATAD1, RAB8B, FAR2, TTC1, DHRS4, PNPLA8, ACSL6

GO:0005779

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integral component of peroxisomal membrane

The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

PEX12, SLC27A2, SLC25A17, PEX11B, PEX3

GO:0005782

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peroxisomal matrix

The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.

NUDT19, AGPS, ACOT8, GNPAT, ACOX3, ECI2, IDH1, NUDT7, HSPD1, IDE, AGXT, SCP2, ABCD3, CRAT, HSD17B4, ACOX1, LONP2, ACOT4, FAR2, ACOX2, HAO2, PIPOX, GRHPR, CROT

GO:0005783

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endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

TMEM129, ELOVL7, KIAA0922, HAX1, RNF103, PLOD2, SCD, TOR1A, HSD17B6, MGST3, CLGN, PDZD2, NPC1, GPR37, P4HA2, INSIG1, HNRNPR, ATP8B1, SLC37A4, CALU, KIF1C, BNIP3L, PLIN1, PARK2, BRINP1, SYNCRIP, TPST2, ICMT, LRP5, PDCD6, MPDU1, ERN1, CLN5, LRP6, CRTAP, PPP1R15A, TRAPPC6A, ARL6IP5, STC2, TM7SF2, PDE9A, SRP72, ERLIN2, SEC31A, NDUFB8, VAPB, PSMG1, STAU1, TMEM50A, CYB5R3, ASS1, SERPINA1, CST3, FOS, HLA-B, APOE, APOC1, ALB, HMGCR, PRNP, VWF, TP53, APOD, CYP17A1, DBI, P4HB, THBS1, ITGA5, STS, HMOX1, FURIN, TRAPPC2, BCL2, MGST1, CYP2D6, TFPI, CLU, HSPA5, CYP19A1, P4HA1, PRKCSH, PLA2G2A, HSP90B1, POU2F1, IFNGR1, ATP2A2, PRKCA, PTPN2, XBP1, ATF6, VCAM1, CAST, MAL, ZP3, TGM2, PPIB, EEF1B2, HSD3B2, PLN, FKBP2, STOM, RPL10, CALR, CANX, PCSK6, EEF1D, ERP29, PDIA3, MIP, HLA-A, HLA-F, AVPR2, LRPAP1, ADORA1, S100A7, MAN1A1, PTGS2, THBS4, SOAT1, CHI3L1, MAP2K2, FDFT1, IFNGR2, DDOST, ANP32A, HTT, CRAT, SSR1, CASP4, TMED10, PSEN1, PSEN2, EMD, SERPINH1, LRBA, BCAP31, RAP1GDS1, PLA2G16, EPHA4, VCP, HADHB, TPD52, TMEM50B, PEX3, NPC2, RRAS2, DLG4, SLC35A2, NUCB2, TMF1, LRP2, SET, COL4A3, MAP2K1, CAV1, PRKCD, BAX, KCNA1, SREBF2, ASPH, GRIN2A, HYAL2, ANK3, DLG1, BNIP3, ARHGAP5, SEMA3B, DNAJC3, CLN3, PDE3B, SLC39A6, SQSTM1, PKD2, RAB32, MLEC, RCN2, PIGH, ITPR3, ITPR1, KCNJ11, EMC2, SLC39A14, RRS1, PDIA6, EBP, RCN1, TMED2, DHCR24, PUM3, SEC23A, NSDHL, MSMO1, ADIPOQ, EXT1, PTGIS, CYP51A1, AOC3, CPEB4, TMEM132A, PGS1, CCDC88A, CERKL, GPAT3, ORMDL2, HS1BP3, MEST, PIGG, CDKAL1, HACD4, ATL3, MCTP1, PTRF, SLC27A1, TXNDC11, CBLN3, CRELD2, HACD2, CERS6, IKBIP, PGAP1, SV2A, FA2H, LPCAT2, EPM2AIP1, SLC36A1, TMC6, GRINA, SYVN1, MTDH, GPAT4, KTN1, SGMS1, SLC26A11, ERO1B, TRAPPC5, P3H2, SULF2, SULF1, SGPP2, DNAJC10, MSRB3, HACE1, ZDHHC14, ABI1, GPC2, CRIPAK, UBE2J2, PHTF2, CERS5, CISD2, POMGNT2, SUMF1, PCSK9, SLC38A9, ATL2, KCNG3, FIBIN, STT3B, HM13, MRAP, AGR3, TRPM4, RNF128, RHBDD1, CEMIP, ZFAND2B, APH1B, SELM, PIEZO1, EDEM1, SORL1, KIFAP3, CDS1, EXT2, PTP4A1, MR1, TMEM203, CCDC47, CREB3L1, APH1A, FAF2, YIPF6, MRAP2, VMP1, ERO1A, VCPIP1, DNAJC1, DHRS1, DGAT2, SMIM14, PANX1, SRPK1, GPX7, SEC62, GPER1, PLIN2, PKMYT1, CHP1, SIGMAR1, MGST2, OLFM1, CIB1, VIMP, CCDC3, INPP5K, ELOVL1, EBPL, SCAPER, PLA2G12A, EDEM3, DERL2, ELOVL4, GABARAPL1, TMX4, EHD4, TOR3A, ELOVL6, FNDC4, ZDHHC6, YTHDC2, ALG9, METTL7A, PLEKHF2, REEP1, CERS4, ZFYVE1, APMAP, ABCB6, CD320, RTN4, MAN1C1, AGPAT3, STAU2, UFSP2, NDFIP2, TMEM30A, CLN6, SMPD4, ELOVL5, UGGT1, ERAP1, HACD3, VAPA, STIM2, RRBP1, ADAMTS9, DPM3, DHCR7, SPAST, CTSZ, DNAJB9, SEL1L, SEC63, USP25, ZDHHC2, MAN1B1, DSE, NRXN1, PYCARD, TMCO1, PHTF1, BOK, STUB1, ANGEL1, MINPP1, POMP, CNPY2, ATP11B, ZDHHC9, GOLT1B, TMED3, MYO5A, HYOU1, TBL2, PCDHA2, PCDHA1, TRAPPC1, IER3IP1, CPQ, POMT1, SLC30A1

GO:0005784

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Sec61 translocon complex

A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events.

SSR4, BCAP31, ARL6IP1

GO:0005785

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signal recognition particle receptor complex

A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex.

SRP9, RP9, SRPRB

GO:0005786

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signal recognition particle, endoplasmic reticulum targeting

A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.

SRP72, SRP14, SRP9, SRP54

GO:0005787

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signal peptidase complex

A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space.

SPCS2

GO:0005788

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endoplasmic reticulum lumen

The volume enclosed by the membranes of the endoplasmic reticulum.

RNASET2, TOR1A, SLC27A2, P4HA2, SELENOF, CRTAP, H6PD, F8, F2, SERPINA1, PDGFB, GCG, INS, CD4, COL1A1, COL3A1, APOA1, APOA2, BGLAP, PDGFA, APOB, COL5A2, P4HB, THBS1, COL1A2, COL4A2, STS, HSPA5, COL11A1, COL6A1, COL6A2, COL6A3, F5, PDIA4, P4HA1, COL11A2, PRKCSH, HSP90B1, ARSA, ARSB, COL9A1, COL5A1, PPIB, COL8A2, COL5A3, CALR, CANX, CFP, ERP29, PDIA3, PTGS2, COL15A1, COL18A1, WNT5A, SERPINH1, ARSD, CTSC, WNT3, B2M, COL4A3, PLAUR, COL10A1, COL14A1, COL16A1, DNAJC3, OS9, COL4A6, RCN2, GAS6, PDIA5, GANAB, PDIA6, RCN1, TOR2A, COL13A1, ERAP2, KDELC1, CES3, ARSK, ADAMTSL4, KDELC2, COL23A1, P3H2, DNAJC10, TOR2A, SUMF1, CYP2W1, GPX8, GBF1, MYDGF, FKBP10, ERO1A, COL21A1, GPX7, COL12A1, ERP44, CNPY3, TMEM43, EDEM3, PDGFD, WNT5B, TOR3A, SPON1, PDGFC, FKBP14, CLN6, UGGT1, ERAP1, CTSZ, DNAJB9, GHRL, ADAMTS7, COL17A1, ADAMTS5, MINPP1, HYOU1, FKBP7, WNT6

GO:0005789

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endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

TMEM129, ELOVL7, TMEM189, HACD1, RNF103, WRB, SLC33A1, PLOD2, SDCBP, SCD, COPE, GOSR2, ABCD4, PTGES, MGST3, CLGN, SLC27A2, SURF4, SPTLC2, GRM6, GPR37, TLR3, INSIG1, FLRT2, CYP26A1, ASNA1, KDELR3, SLC37A4, CALU, AHCYL1, FADS1, ACSL4, ICMT, TRIM13, PDCD6, MPDU1, SEC22B, ERN1, PPP1R15A, SC5D, DHRS3, ARL6IP5, TM7SF2, SEC24D, TMCC1, ERLIN2, SEC31A, CLSTN1, CSPG5, VAPB, CTDNEP1, ABCA1, CDS2, FADS2, CH25H, CYB5A, CYB5R3, EGFR, TGFA, CD4, HMGCR, APOB, CYP1A1, CYBB, CYP17A1, CYP2E1, UGT2B4, EPHX1, CYP3A4, CYP21A2, STS, HMOX1, UCHL1, BCL2, MGST1, CYP2D6, HSPA5, CYP2A6, CYP19A1, SFTPC, CYP2C9, PSKH1, HSD3B1, PLA2G2A, HSP90B1, FOLR1, AREG, CD1D, ATP2A2, GJA1, XBP1, SRD5A1, ATF6, CYP2B6, CYP3A5, OSBP, AADAC, PTGS1, KDELR1, CYP3A7, HSD3B2, FKBP2, CANX, HSD11B1, SRI, SRD5A2, FMO4, ACSL1, PTGS2, G6PC, SOAT1, GJC1, SREBF1, HSD17B2, FDFT1, PIGA, GGCX, IFNGR2, DDOST, PMEL, PTGDS, TMPO, TMPO, SSR1, NOTCH1, STT3A, PLA2G4A, ARCN1, LSS, PTDSS1, PITPNB, PCYT1A, CASP4, TMED10, PSEN1, PSEN2, RAB9A, BCAP31, ALDH3A2, VAMP7, COPA, ATXN3, VCP, SEC13, HSD17B7, ANTXR2, SEC61G, CDC42, RAB2A, RHOA, DAD1, COPZ1, RAB1A, RAC1, EIF5A, PIP4K2B, HSD11B2, FKBP3, FKBP4, PLOD1, DST, CAV1, PLAUR, NOTCH2, TYRO3, PIGF, BAX, DMPK, GALNT2, GALNT1, SREBF2, ASPH, LRMP, DLG1, PLD1, OS9, FKBP5, PKD2, MLEC, PIGH, NFE2L1, SQLE, PDIA5, ITPR2, ITPR3, ITPR1, LPIN1, SPCS2, ARL6IP1, RAB3GAP1, PDIA6, EBP, TMED2, RHEB, DHCR24, SEC23A, NSDHL, MSMO1, EXT1, PTGIS, CYP1B1, CYP51A1, DUOXA1, DUOXA2, TMEM132A, PIGY, TMEM259, GPAT3, HSD17B12, TTMP, MEST, PIGG, ALG10B, WLS, CDKAL1, ATL3, REEP3, ERAP2, LPCAT3, SLC27A4, LRRC8B, TXNDC11, AGTRAP, MOXD1, SHISA2, LCLAT1, SEZ6L2, CYP2R1, HACD2, CERS6, CYP4V2, MBOAT2, IKBIP, ILDR2, PGAP1, FA2H, LPCAT2, ERMP1, TMC6, CYP2U1, PIGW, TMED4, SCD5, SYVN1, MTDH, GPAT4, KTN1, SLC51A, ANKLE2, ERO1B, GPSM1, SGPP2, RDH10, ARMC10, UBE2J2, CERS5, CISD2, MFSD2A, POMGNT2, TMEM178A, SVIP, ATL2, MCFD2, CYP2W1, ABHD4, PIGX, DNAJB14, RDH11, MARCH1, HM13, MRAP, LRRC8C, RHBDD1, NUP210, RAB2B, TMEM170A, PIEZO1, PIGC, SLC9A6, LPGAT1, PIGK, CDS1, EXT2, MR1, YIPF5, PIGT, TMEM203, NCLN, ERGIC1, PNPLA2, FKBP10, CREB3L1, APH1A, RHBDF1, MRAP2, ERO1A, SEC22A, SEC16B, FAR2, DNAJC1, CARD19, MBOAT7, NECAB3, DGAT2, NOX5, SMIM14, PANX1, ERGIC2, LMF1, SEC62, PCYT2, SDF2, FMO2, GPER1, PKMYT1, MGLL, SIGMAR1, MGST2, DHRS9, VKORC1, APOL2, ERP44, DHRS4, G6PC3, APOO, ALG8, TMEM106C, ELOVL1, TAPBPL, EBPL, SEC11C, OSBPL8, OSBPL6, EPT1, LNP, DERL2, EIF5A2, RAB1B, LMAN2L, XYLT2, HSD3B7, RAB3GAP2, PIGU, CLSTN2, ELOVL6, ZDHHC6, ALG9, RNF121, SEC61A2, CERS4, SLC28A3, CYP3A43, GBA2, ABCB6, ALG13, PNPLA8, NOX4, RTN4, CYP26B1, UBQLN4, SERINC1, AGPAT4, AGPAT3, PNPLA3, SLC35D1, FKBP14, CLN6, SMPD4, FKBP11, ELOVL5, ERAP1, FMN2, FLRT3, FLRT1, SEPN1, JKAMP, VAPA, STIM2, DPM3, PEMT, DHCR7, SPAST, DNAJB9, SEL1L, VTI1B, SEC63, MAN1B1, C14orf1, ACSL6, AMFR, RAB21, NDRG4, BOK, SSR3, CYP8B1, PLA2G4C, MAPK8IP1, RCE1, ERGIC3, MYRF, ZDHHC9, TMED5, RTCB, TMED3, PCYT1B, SRPRB, IER3IP1, ALG6, COPG1, FKBP7, POMT1, SAR1B, CEPT1

GO:0005790

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smooth endoplasmic reticulum

The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.

MYO1D, APP, TH, HSPA5, PPIB, CALR, CANX, ERP29, SRI, PSEN1, PRDX4, DNAJC3, SLMAP, RYR3, SYVN1, RYR2, GBA2, MAPK8IP3, HYOU1

GO:0005791

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rough endoplasmic reticulum

The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.

STAU1, BGLAP, CYBB, APP, HSPD1, CCL2, ARSB, CA4, MT3, CANX, SNCA, PTGDS, ADCYAP1R1, PSEN1, EPHA5, SEC61A1, NUCB1, TRAM2, TMEM97, CDKAL1, PCSK9, SPPL3, HM13, CCDC47, SEC62, FKRP, LIN28A, RANGRF, SLC7A11

GO:0005793

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endoplasmic reticulum-Golgi intermediate compartment

A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.

SURF4, SEC22B, STK17B, FN1, P4HB, HMGB1, HSPA5, PTPN2, CA4, KDELR1, MAN1A1, TMED10, SERPINH1, IST1, NUCB2, NUCB1, PDIA6, TMED2, RGMB, GBF1, MYDGF, ERGIC1, SCYL1, CCDC115, CHP1, ERP44, LMAN2L, SLC35C2, RAB6B, UGGT1, DICER1, TMED5, TMED3

GO:0005794

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Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

GOLGA8A, HIP1, IPO5, PIK3C2A, GOLIM4, BTN3A3, PLPP3, BHLHE40, COPE, AP3D1, GOSR2, ADAM10, RAB29, NPC1, SCAMP2, ARPC2, PLSCR1, LEPROT, HDAC3, AKR7A2, B4GAT1, ATP8B1, SPRY1, ITM2A, STX6, CALU, KIF1C, PARK2, ADCY3, TPST1, NMT2, TLR2, TPST2, DIAPH2, FAM20B, OBSL1, VAMP4, CLN5, STX11, LRP6, RP2, SCRG1, PPP1R15A, AP1G2, STC2, PDE9A, ZFPL1, CSPG5, KIF20A, TNKS, VAPB, SNAPIN, PSMG1, LARGE, ABCA1, CXCL14, SERPINA1, NRAS, LDLR, HLA-B, COL1A1, CRYAB, APOE, ALB, ESR1, RAF1, APOB, PRNP, CYBB, APP, DBI, GALT, LYN, CD14, ITGA5, GNAI3, STS, SRGN, HSPD1, CLU, PSKH1, PTHLH, BMP1, B4GALT1, ARSB, CD44, CD36, CPE, GJA1, SYN1, TCP1, ARF4, ATF6, LIG1, VCAM1, FUT1, CCNA2, SYT1, ZP3, FGF7, FGFR2, OSBP, FUT4, GAL, CA4, XPA, PTGS1, IGFBP6, F2R, MAPK3, CALR, MAPK1, CTGF, HLA-A, AVPR2, GDI1, STIP1, MAN1A1, CTNNA1, MAP2K2, PPARG, SNCA, PLA2G5, PMEL, ID1, AQP2, PTGDS, HTT, PLA2G4A, ARCN1, SLC1A6, CSNK1D, TGM4, FASN, PSMB3, TMED10, PSEN1, PSEN2, TSC2, GDI2, ERF, LRBA, RNF144A, PPT1, RAB7A, RAB27A, CAV2, CLCN3, MSH6, AP3M2, EPHA4, EMP2, F2RL1, AP1S2, AP3S2, GABARAPL2, ZP1, B2M, AP1S1, NCS1, RAB11A, RAB1A, GRB2, DYNLT1, SLC35A2, SLC35A1, NUCB2, TMF1, ARF5, LRP2, ATP2C1, APBA1, SP3, MAP2K1, NUCB1, ICA1, GOLGA2, MGAT2, GALNT2, GALNT1, BST2, FUT2, ANK3, DLG1, STRN3, CLN3, PDE3B, PLD1, GOLGA4, PICALM, SNX1, PWP1, PTCH1, CUX1, CDK13, CTTN, NEDD9, GANAB, CUL7, NAA25, RAB3GAP1, SLC39A14, PRKD1, TMED2, TLR1, TAF11, MMD, TRIP11, MAPRE1, SLC1A5, EXT1, AOC3, TMEM132A, GNPTAB, CCDC88A, GLYR1, CERKL, LARP7, PREPL, ESCO2, WDR44, RABGAP1L, MANEA, ARHGAP21, WLS, GKAP1, PDE4DIP, GLT8D1, LAMTOR1, AFTPH, CBLN3, PARM1, DRAM2, CRELD2, FGD6, BEND5, TMC6, GRINA, CCDC91, FGD2, SERINC5, CAND1, HOOK3, SLC26A11, CEP57, ZDHHC17, HID1, P3H2, ARL17A, SULF1, FAM20C, SCYL3, XRN1, MAML2, VPS52, NLGN1, ASCC3, GALNT4, MINK1, ARFGAP2, GOLM1, PCSK9, TNRC6A, GLIS3, USP32, SGMS2, FIBIN, MPLKIP, SLC35G2, BICD2, TRPM4, PXYLP1, RNF128, ATP8B4, SECTM1, SELM, SEC14L1, FAM3C, GBF1, TOPBP1, SORL1, KAT6A, GOLGA1, PCSK5, RPGR, KIFAP3, GLG1, ARHGEF2, ATP6V0A1, EXT2, TMBIM1, JAKMIP2, APH1A, OPTN, RAB39B, C11orf24, PERP, BICD1, SCYL1, FGD4, ARAP1, PASK, ERGIC2, LMF1, OSBPL9, GPER1, MPHOSPH9, PKMYT1, FEZ1, LITAF, CDC6, CIB1, ARID3A, MAPKAP1, SOST, SDF4, TMEM43, PDCD10, DUSP26, TIPIN, JAM3, OSBPL11, FUT8, RAB34, PRKD2, PLA2G12A, SPRY4, CHST5, CHST6, ADAM19, GABARAPL1, RAB1B, LMAN2L, ACBD3, FZD8, DDX31, AKTIP, FKRP, TMEM165, CWC22, GOPC, ABCB6, ARFGAP3, SLC35C2, ASH1L, RAB6B, NDFIP2, TMEM30A, HAUS2, SMPD4, ZDHHC7, AATF, BET1L, STMN3, CLIC5, EHF, GRHL1, TBC1D14, STARD9, VTI1B, ZDHHC2, GNPTG, GGA2, GGA1, MAN1B1, MYH2, DSE, MTUS1, MYO6, PLAGL1, BOK, SYNRG, NDRG2, MACF1, HDAC5, ZNF148, AKT3, RUVBL1, ERGIC3, ITM2B, SLC35A3, ATP11B, CRYL1, AP3M1, ZDHHC9, TMED5, TMED3, TRRAP, MYO5A, CEP83, IER3IP1, LIPG, CPQ, COPG1, SLC30A1, DUSP10

GO:0005795

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Golgi stack

The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.

RAB27B, NSF, OCRL, MGAT2, GALNT2, CLN3, COG2, DNMBP, LPCAT2, SULF2, SULF1, GBF1, VCPIP1, VRK1, RAB34, ZFYVE1, NSFL1C

GO:0005796

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Golgi lumen

The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.

AGRP, GOLIM4, NCAN, HS3ST1, SDC3, GPC4, CSPG5, F2, TGFB1, NGF, CGA, LHB, INS, BGLAP, VTN, DCN, SOD3, FURIN, DEFA4, VCAN, MUC1, SDC1, OGN, BGN, MMP11, PCSK6, SDC4, SDC2, GPC1, WNT5A, MMP14, MMP16, LUM, WNT3, MUC5AC, HSPG2, MUC3A, FMOD, PPIL2, GAS6, MUC21, CSPG4, GPC2, MUC20, MUC15, PCSK5, MUCL1, BCAN, MUC4, OMD, SDF4, WNT5B, BLZF1, MUC13, GPC6, WNT6

GO:0005797

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Golgi medial cisterna

The middle Golgi cisterna (or cisternae).

HID1, TMEM59

GO:0005798

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Golgi-associated vesicle

Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.

ADAM10, AP1G2, GNRH1, TYR, OCRL, NUCB1

GO:0005801

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cis-Golgi network

The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.

GOLIM4, RAB29, KDELR1, PIK3R1, CTGF, TMED10, LIMK2, NUCB1, GOLGA2, TRIP11, HOOK3, GBF1, YIPF6, SCYL1, SLC35C2, PHTF1, ANGEL1, TMED5

GO:0005802

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trans-Golgi network

The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

GSAP, RAB29, SCAMP1, STX6, ATP9A, SOD3, FURIN, IGF2R, PAM, CA4, LAP3, VAMP7, SNAP25, RAB11A, RAC1, AP2B1, VAMP2, ARF1, ATP2C1, OCRL, NUCB1, STX4, CLN3, GOLGA4, RAB32, POSTN, PRKD1, TGFBI, TRIP10, TJAP1, WIPI1, FNBP1L, WLS, DENND5A, CNST, KIAA1324, CHST4, PIFO, GBF1, SORL1, GOLGA1, OPTN, YIPF6, BICD1, ARAP1, FNBP1, GPER1, INPP5K, CHAC1, RBFOX1, SMPD4, SCOC, GGA2, RAB21, CHST2, SNX9, ARFGEF2

GO:0005811

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lipid particle

An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

PLIN1, ACSL4, CYB5R3, GAPDH, ANXA2, FABP4, ALOX15, G0S2, ALDH3B2, LSS, RAB5C, RAB7A, BCAP31, IRAK1, VCP, PLIN5, CAV1, LIPE, RAB3GAP1, NSDHL, LPCAT2, PNPLA5, SPG20, HSD17B11, ABHD4, ABHD5, GBF1, PNPLA2, ATG2B, FAF2, DGAT2, PLIN4, PLIN2, SIGMAR1, AIFM2, REPIN1, METTL7A, PNPLA3, SPAST, PRPF19, STARD13, HILPDA

GO:0005813

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centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

C4orf47, DCTN6, PLK4, ELL2, CHEK1, AURKA, PPP1R12A, ARHGEF10, SMAD7, CETN3, DYNC1LI2, WDR62, SSNA1, NUDT21, ROCK2, OBSL1, RAB11FIP3, VPS4B, USP2, OFD1, RAD51D, HAUS5, CEP152, CCNB2, PCNT, SNAP29, DDAH2, GNAI2, CDK1, NPM1, GNAI3, G6PD, PCNA, SKI, PRKAR2A, CCNB1, NME1, ZNF12, PRKACA, TCP1, MAK, TUBG1, CDK2, APC, MCM3, PSMA1, PSMB5, MARCKS, CDC27, CDC25B, CLIP1, PRKAR2B, CTNNB1, MDH1, ID1, ACTR1B, SLC1A4, RANBP1, CSNK1A1, CSNK1D, MAPKAPK2, CENPF, PSEN1, PSEN2, GSK3B, CCT8, BRCA2, NEK2, NEK3, PLK1, IST1, NUP107, ATP6V0D1, CALM2, RAB11A, GNAI1, DYNLL1, SKP1, CDK6, KIF23, ID2, PDE4D, CAMSAP2, MZT1, CCDC15, CDC20, DYNC1I2, XRCC4, UNC119, DCTN2, CKAP5, DCTN1, DYNC1H1, ESPL1, CHD4, CUL7, FAM175B, PCM1, STIL, MAPRE1, CCDC85B, PKN2, CSPP1, KIZ, ERCC6L, FAM161A, CCDC14, CEP55, ODF2, SGOL1, CEP78, CEP170, UBR4, CROCC, PDE4DIP, CEP135, TTC19, MZT2A, CCDC81, NEK10, HAUS6, PCGF5, SDCCAG8, HOOK3, CEP57, MIB1, BBS7, SIRT2, CKAP2L, CNTROB, AHI1, NIN, C7orf31, CEP120, POC1A, VPS37A, BBS1, CEP70, TTC8, MPLKIP, MDM1, POC1B, NEK9, FBF1, GSG2, CKAP2, PIBF1, IFT81, TOPBP1, NDRG1, RPGR, KIFAP3, MED12, CLUAP1, SYTL4, HAUS1, TUBGCP3, TBC1D31, HOOK2, MVB12A, ZNF274, MASTL, ZFYVE19, RITA1, MARK4, IFT74, CEP19, FOPNL, NEK1, ALS2, KIF20B, CEP89, MPHOSPH9, FEZ1, CIB1, HAUS7, NCAPG, SLF1, CCDC77, DCTN5, KATNB1, IFT27, SORBS1, LRRCC1, CEP44, NDEL1, SPATC1L, CCDC8, TSPYL2, IKZF4, RGCC, HAUS4, AUNIP, PHAX, TTC12, MEAF6, CENPJ, MKKS, CYLD, IFT46, MBNL1, KIF15, RAD18, DCAF13, RNF19A, HAUS2, MKS1, NDE1, AATF, PLK2, DTL, ITSN2, CAMSAP3, SLAIN2, WDR35, WRAP73, UXT, SPAST, FBXL7, NDRG2, CDC14A, PROCR, B9D1, USP20, RABGAP1, KIF3A, HSPB11, NME7, ATP6V1D, MAD1L1

GO:0005814

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centriole

A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.

WASH1, PLK4, AURKA, CETN3, WDR62, CEP104, OFD1, RP2, CEP152, PCNT, HSPA1A, HSPA1B, TOP2A, HSPA6, TUBG1, CAPG, CCNF, HTT, PCM1, STIL, CEP55, ODF2, CEP170, CROCC, CEP135, CEP128, SDCCAG8, SIRT2, CNTROB, AHI1, NIN, CEP120, POC1A, MDM1, POC1B, FBF1, TUBGCP3, WDR34, CEP19, CEP89, MPHOSPH9, LRRCC1, CENPJ, MKS1, PLK2, STARD9, WRAP73, TUBD1, TSKS, CEP83

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