| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0000244 | BP | spliceosomal tri-snRNP complex assembly | The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. |
PRPF3, SRSF10, CD2BP2, SART3, PRPF31, DDX20, PRPF19 |
GO:0000245 | BP | spliceosomal complex assembly | The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. |
GCFC2, RBM5, SNRPD1, SNRPD2, SNRPD3, SRPK2, SART3, GEMIN6, SCAF11, CRNKL1, PRPF19, LSM4 |
GO:0000246 | MF | delta24(24-1) sterol reductase activity | Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH. |
DHCR24 |
GO:0000247 | MF | C-8 sterol isomerase activity | Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. |
EBP |
GO:0000248 | MF | C-5 sterol desaturase activity | Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. |
FADS1, SC5D |
GO:0000250 | MF | lanosterol synthase activity | Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. |
LSS |
GO:0000252 | MF | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity | Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H. |
NSDHL |
GO:0000253 | MF | 3-keto sterol reductase activity | Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+). |
HSD17B7, DHRS4 |
GO:0000254 | MF | C-4 methylsterol oxidase activity | Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O. |
CH25H, MSMO1 |
GO:0000255 | BP | allantoin metabolic process | The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism. |
GHR, STAT5A, STAT5B |
GO:0000266 | BP | mitochondrial fission | The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. |
PARK2, OPA1, MTFR1, MTFR2, MFF |
GO:0000271 | BP | polysaccharide biosynthetic process | The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. |
NDST1, GLT8D1 |
GO:0000272 | BP | polysaccharide catabolic process | The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. |
CHIT1 |
GO:0000274 | CC | mitochondrial proton-transporting ATP synthase, stator stalk | One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. |
ATP5H |
GO:0000275 | CC | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) | The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. |
ATP5D, ATP5C1, ATP5E |
GO:0000276 | CC | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. |
ATP5L, ATP5J, ATP5G3, ATP5I, ATP5G2 |
GO:0000278 | BP | mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
RRM1, CDC25B, CENPF, NEK4, CDH13, CENPE, CENPC, PAK2, FAM175B, CENPW, KIF18B, CDC5L, AZI2, NUDT15, STK24 |
GO:0000281 | BP | mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
KIF20A, KIF4A, STAMBP, STMN1, SON, RASA1, APC, CENPA, PLK1, SPTBN1, KIF23, ANK3, CUL7, CEP55, SNX33, MITD1, CKAP2, SNX18, NUSAP1, RACGAP1, CHMP4B, ANLN, SPAST, SNX9 |
GO:0000285 | MF | 1-phosphatidylinositol-3-phosphate 5-kinase activity | Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). |
PIP5K1B, PIKFYVE |
GO:0000287 | MF | magnesium ion binding | Interacting selectively and non-covalently with magnesium (Mg) ions. |
CIB4, ILVBL, GTPBP10, EYA2, PDXK, MAP2K7, MAST4, MAP3K7, ATP8B1, IDH3B, OPA1, ATP9A, ERN1, RPS6KA5, PPM1B, IDH1, DXO, FARS2, TDP2, LATS1, NUDT3, ENO1, ENO2, NUDT7, TOP2A, PRPS2, ENO3, MTHFD2, PKM, NME1, COMT, S100P, IMPA1, WEE1, ADSS, DUT, PCK1, HMGCL, PGM1, SNCA, FEN1, MAP3K8, ABL2, MSH2, GCLC, IDH2, INPP1, PAPOLA, MSH6, ADPRH, GEM, SIK1, PTEN, PRPS1, NCS1, GNAI1, SRPK2, ARF1, STK4, ITPK1, STK38, RPS6KA2, RPS6KA1, STK11, CDC42BPA, MAST2, ENOSF1, CLYBL, ADSSL1, XXYLT1, ATP8B4, DYRK2, NUDT16, PGM2, SRPK1, MAP3K5, TREX2, PINK1, SIK2, PPA2, WNK1, MTG2, PIF1, DCTPP1, RRAGC, NEK6, PRTFDC1, AASDHPPT, MTPAP, SPHK1, ZAK, MARK1, NLK, NUDT5, ATP11B, STK38L, SIK3, FAN1, CDC42BPB, IRAK3 |
GO:0000288 | BP | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. |
POLR2D, CNOT3, ZFP36, ZFP36L2, ZFP36L1 |
GO:0000289 | BP | nuclear-transcribed mRNA poly(A) tail shortening | Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. |
CNOT1, CNOT3, PARN, CNOT4, EIF4E, EIF4B, ZFP36, MLH1, EIF4A1, EIF4A2, PAN3, SAMD4B, PAIP1, CNOT7, CNOT6, SAMD4A |
GO:0000290 | BP | deadenylation-dependent decapping of nuclear-transcribed mRNA | Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length. |
PAN3, DCP2, CNOT7, NOCT |
GO:0000291 | BP | nuclear-transcribed mRNA catabolic process, exonucleolytic | The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. |
POLR2G |
GO:0000293 | MF | ferric-chelate reductase activity | Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+). |
CYBRD1 |
GO:0000295 | MF | adenine nucleotide transmembrane transporter activity | Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other. |
SLC25A17 |
GO:0000298 | MF | endopolyphosphatase activity | Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. |
NUDT3, NUDT10, NUDT11 |
GO:0000301 | BP | retrograde transport, vesicle recycling within Golgi | The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. |
CUX1 |
GO:0000302 | BP | response to reactive oxygen species | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. |
CCS, GSR, APOE, SOD2, CYBB, APOD, GPX1, P4HB, SOD3, GSTP1, TXN, GPX3, PRDX6, S100A7, PRDX2, CYCS, PRDX1, HYAL2, TXNRD1, GPX8, ERO1A, NOX5, GPX7, TXN2, NOX4, PPARGC1A |
GO:0000303 | BP | response to superoxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. |
SOD2, UCP2, UCP3 |
GO:0000307 | CC | cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
CDK4, CDK2, CCND2, CCND3, CKS2, CDKN1A, CKS1B, CDK6, CCNL2, CCNL1 |
GO:0000309 | MF | nicotinamide-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. |
NMNAT3 |
GO:0000320 | BP | re-entry into mitotic cell cycle | The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state. |
CCNF, GSK3B |
GO:0000322 | CC | storage vacuole | A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules. |
CDC42, STX4, ARHGEF7 |
GO:0000338 | BP | protein deneddylation | The removal of a ubiquitin-like protein of the NEDD8 type from a protein. |
TOR1A |
GO:0000339 | MF | RNA cap binding | Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
EIF4G3, EIF4E2, EIF4E, EIF4A1, NCBP1, LARP1 |
GO:0000340 | MF | RNA 7-methylguanosine cap binding | Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
NCBP3, AGO2 |
GO:0000346 | CC | transcription export complex | The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. |
ZC3H11A, SARNP, THOC7, ALYREF, THOC2, THOC3, POLDIP3, NXF1 |
GO:0000347 | CC | THO complex | The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits. |
THOC7, THOC2 |
GO:0000350 | BP | generation of catalytic spliceosome for second transesterification step | Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. |
PRPF18 |
GO:0000354 | BP | cis assembly of pre-catalytic spliceosome | Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner. |
DDX23 |
GO:0000375 | BP | RNA splicing, via transesterification reactions | Splicing of RNA via a series of two transesterification reactions. |
PRPF3, SRSF10, TRA2B, SF3A3, SRRM1, KHSRP, SNRNP40, SCAF11, DDX23 |
GO:0000380 | BP | alternative mRNA splicing, via spliceosome | The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. |
KDM1A, PQBP1, SFPQ, PTBP1, HNRNPM, SRSF1, SRSF6, CDK13, RBM17, RSRC1, ESRP2 |
GO:0000381 | BP | regulation of alternative mRNA splicing, via spliceosome | Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. |
SAP18, RBFOX2, HNRNPL, DDX5, PTBP1, RBMX, RBM25, RBM5, TRA2B, SRSF2, FMR1, SRSF6, WTAP, RNPS1, MBNL2, UHMK1, SREK1, RBM4, RBFOX1, THRAP3, RBM8A |
GO:0000384 | MF | first spliceosomal transesterification activity | Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon. |
RBMX2 |
GO:0000386 | MF | second spliceosomal transesterification activity | Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. |
PRPF18 |
GO:0000387 | BP | spliceosomal snRNP assembly | The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. |
SNRPC, SNRPB, GEMIN4, SNRPF, SNRPD1, SNRPD2, SNRPD3, SART3, GEMIN5, GEMIN6, RBM22, GEMIN8, DDX20, LSM4 |
GO:0000389 | BP | mRNA 3'-splice site recognition | Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome. |
SF3A3 |
GO:0000395 | BP | mRNA 5'-splice site recognition | Recognition of the intron 5'-splice site by components of the assembling spliceosome. |
PSIP1, SNRPC, SRSF1, PRPF39 |
GO:0000398 | BP | mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
DDX39A, POLR2D, DHX15, HNRNPR, PRPF3, PPIH, PLRG1, NUDT21, DHX16, SYNCRIP, PRPF40A, SRSF10, CD2BP2, LSM8, HNRNPC, SNRPA, SNRPC, HNRNPA1, SNRPA1, GTF2F2, SNRPB, HNRNPL, DDX5, POLR2E, HNRNPA2B1, POLR2A, PTBP1, POLR2B, HNRNPH3, HNRNPH1, GTF2F1, FUS, POLR2I, RBMX, BUD31, SKIV2L2, PAPOLA, NOVA1, HNRNPA3, HNRNPM, POLR2J, RBM5, POLR2K, SNU13, HNRNPH2, SNRPF, LSM3, LSM6, SNRPD1, SNRPD2, SNRPD3, POLR2G, POLR2L, TRA2B, SNRPN, YBX1, HNRNPU, SRSF2, SRSF11, SRSF1, NCBP1, CPSF1, SF3A3, CSTF3, SRSF9, SRSF5, SRSF6, PRPF4B, TRA2A, HNRNPD, SART3, NONO, RNPS1, PCBP1, ELAVL1, SNRNP35, FIP1L1, CWC27, DDX46, DHX32, PABPN1, ALYREF, CCAR1, SRRM1, ZCRB1, GEMIN5, SNRNP27, PRPF31, GEMIN6, PSPC1, RBPMS, SNRNP40, RSRC1, RNPC3, ZMAT2, RBM15, SPEN, CDC5L, BUD13, HNRNPUL1, DDX23, SNRNP25, SF3B5, CRNKL1, PNN, DHX35, METTL14, CWC22, RAVER2, RBM22, CWC15, CPSF2, LSM7, PRPF19, PPIE, NOVA2, SRRM2, LSM2, RBMX2, SF3B6, LSM5, LSM4, RBM8A |
GO:0000400 | MF | four-way junction DNA binding | Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. |
HMGB3, RAD51C, RAD51D, HMGB1, YY1, HMGB2, MSH2, MSH6, RAD51 |
GO:0000403 | MF | Y-form DNA binding | Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. |
MSH2, RAD18 |
GO:0000404 | MF | heteroduplex DNA loop binding | Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. |
MSH2, XPC |
GO:0000405 | MF | bubble DNA binding | Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. |
RECQL4, HMGB1, BLM, XPC, NEIL3 |
GO:0000406 | MF | double-strand/single-strand DNA junction binding | Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA. |
MSH2 |
GO:0000407 | CC | pre-autophagosomal structure | A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes. |
ATG13, SQSTM1, NBR1, WIPI1, ATG2B, VMP1, ZFYVE1, WIPI2 |
GO:0000408 | CC | EKC/KEOPS complex | A protein complex involved in t6A tRNA modification; originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p. |
TP53RK |
GO:0000413 | BP | protein peptidyl-prolyl isomerization | The modification of a protein by cis-trans isomerization of a proline residue. |
PPIH, PPIB, FKBP2, PPIF, NKTR, PPIC, RANBP2, PPIA, FKBP3, FKBP4, PPID, PPIL2, PPIG, FKBP5, PPP2R4, CWC27, PPIL4, FKBP10, FKBP14, FKBP11, PPIE, PIN4, FKBP7 |
GO:0000421 | CC | autophagosome membrane | The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. |
SNAP29, RAB7A, GABARAPL2, CALCOCO2, WIPI1, TECPR1, ATG16L2, VMP1, MAP1LC3B, GABARAPL1, MAP1LC3A, SH3GLB1 |
GO:0000422 | BP | mitophagy | The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions. |
PARK2, ATG12, GABARAPL2, BNIP3, SQSTM1, WIPI1, CISD2, RB1CC1, ATG2B, FUNDC2, PINK1, GABARAPL1, MAP1LC3A, PPARGC1A, WDR45, WIPI2 |
GO:0000430 | BP | regulation of transcription from RNA polymerase II promoter by glucose | Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
USF2 |
GO:0000432 | BP | positive regulation of transcription from RNA polymerase II promoter by glucose | Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter. |
USF2 |
GO:0000435 | BP | positive regulation of transcription from RNA polymerase II promoter by galactose | Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter. |
NCOA1 |
GO:0000439 | CC | core TFIIH complex | The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD. |
ERCC2, GTF2H1, GTF2H2, GTF2H2C_2, GTF2H4 |
GO:0000444 | CC | MIS12/MIND type complex | A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1. |
NSL1, DSN1 |
GO:0000445 | CC | THO complex part of transcription export complex | The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits. |
THOC7, THOC2, THOC3 |
GO:0000446 | CC | nucleoplasmic THO complex | The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits. |
THOC7 |
GO:0000447 | BP | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
UTP20, RPSA, RPS21, RRS1, RCL1, FCF1 |
GO:0000448 | BP | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
BOP1 |
GO:0000453 | BP | enzyme-directed rRNA 2'-O-methylation | The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA. |
MRM1 |
GO:0000454 | BP | snoRNA guided rRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation. |
NOP10, GAR1 |
GO:0000460 | BP | maturation of 5.8S rRNA | Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. |
NSA2, SKIV2L2, EIF6, C1D, EXOSC4, WDR37, LAS1L |
GO:0000461 | BP | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. |
RPSA, RPS21 |
GO:0000462 | BP | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
UTP20, RPS8, RPS16, RPS14, TBL3, TSR1, NGDN, EMG1, UTP23, DCAF13, CCDC59, WDR3, FCF1, UTP18 |
GO:0000463 | BP | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
RPL7, RPL35, BOP1, WDR12 |
GO:0000466 | BP | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
WDR12 |
GO:0000467 | BP | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. |
ERI2, ERI3, EXOSC9, EXOSC2, EXOSC7, EXOSC8, EXOSC3 |
GO:0000469 | BP | cleavage involved in rRNA processing | Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. |
NOB1 |
GO:0000470 | BP | maturation of LSU-rRNA | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. |
RSL1D1, NSA2, NOP2, SNU13, EIF6, RPL7A, RPL10A, MRPL1, WDR37, LAS1L |
GO:0000472 | BP | endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. |
UTP20 |
GO:0000478 | BP | endonucleolytic cleavage involved in rRNA processing | Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA. |
LAS1L |
GO:0000479 | BP | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae. |
TSR1 |
GO:0000480 | BP | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. |
UTP20, UTP23, RCL1, FCF1 |
GO:0000492 | BP | box C/D snoRNP assembly | The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex. |
NUFIP1, RUVBL2, RUVBL1 |
GO:0000495 | BP | box H/ACA snoRNA 3'-end processing | Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule. |
DKC1 |
GO:0000502 | CC | proteasome complex | A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. |
PSMD11, PSMD12, PSMD3, PSMD10, HSPB1, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, RAD23A, RAD23B, VCP, SHFM1, PSME3, PSMC1, PSMC6, PSMD2, UBE3C, ADRM1, UBR1, PAAF1, PSMG3 |
GO:0000506 | CC | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex | An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast. |
PIGA, PIGH, PIGY, PIGC |
GO:0000578 | BP | embryonic axis specification | The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. |
COBL, CTNNB1, STIL, CITED1 |
GO:0000701 | MF | purine-specific mismatch base pair DNA N-glycosylase activity | Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. |
PCNA |
GO:0000703 | MF | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. |
NTHL1, SMUG1 |
GO:0000707 | BP | meiotic DNA recombinase assembly | During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA. |
RAD51D |
GO:0000710 | BP | meiotic mismatch repair | A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. |
ERCC1, MSH3, MSH2, MSH6 |
GO:0000712 | BP | resolution of meiotic recombination intermediates | The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged. |
EME2, STRA13, TOP2A, MLH1, FANCM, APITD1, ERCC4, EME1 |
GO:0000715 | BP | nucleotide-excision repair, DNA damage recognition | The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. |
PARP1, UBC, XPA, RAD23B, RBX1, RPS27A, UBA52, XPC, CUL4A, CUL4B, COPS6, COPS8, COPS7B |
GO:0000717 | BP | nucleotide-excision repair, DNA duplex unwinding | The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. |
PARP1, UBC, ERCC2, XPA, GTF2H1, RAD23B, RBX1, RPS27A, UBA52, XPC, CUL4A, CUL4B, GTF2H2, CHD1L, GTF2H4 |
GO:0000720 | BP | pyrimidine dimer repair by nucleotide-excision repair | The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. |
ERCC1 |
GO:0000722 | BP | telomere maintenance via recombination | Any recombinational process that contributes to the maintenance of proper telomeric length. |
RAD51C, POLA1, PCNA, LIG1, POLD1, RPA3, RFC4, RFC2, FEN1, RFC5, RFC3, PRIM1, PRIM2, DNA2, BRCA2, POLE2, RAD51, POLE, POLA2, POLD3, SMC5, RAD50, SMC6, TEP1, POLD4 |
GO:0000723 | BP | telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
NBN, RAD51D, PCNA, XRCC5, SP100, POLD1, DNA2, TERF1, POLD3, PTGES3, RAD50, ERCC4, ACD, SMG1, PIF1, OBFC1, POLD4 |
GO:0000724 | BP | double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
AP5Z1, RAD51C, NBN, POLQ, RAD51D, FSBP, PARP1, H2AFX, SFPQ, YY1, RPA3, BRCA1, FEN1, RECQL, MRE11A, BRCA2, BLM, SHFM1, RAD51, SPIDR, SWI5, SMC5, FBXO18, WDR48, HELQ, RAD54L, RAD50, ERCC4, NABP1, RAD51AP1, TONSL, SMC6, NABP2, NUCKS1, MORF4L1, MCM8, FAN1, RAD54B |
GO:0000725 | BP | recombinational repair | A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. |
RHNO1 |