| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0005112 | MF | Notch binding | Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. |
NOTCH1, JAG1, ADAM17, AAK1, DNER, CHAC1, DLL4, NCOR2 |
GO:0005113 | MF | patched binding | Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins. |
DHH, CCNB1, CAV1, PTCH1, BBS1 |
GO:0005114 | MF | type II transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type II transforming growth factor beta receptor. |
TGFB1, TGFBR1, TGFB2, TGFBR3, BAMBI |
GO:0005115 | MF | receptor tyrosine kinase-like orphan receptor binding | Interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror). |
WNT5A |
GO:0005119 | MF | smoothened binding | Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals. |
PTCH1, BBS1 |
GO:0005123 | MF | death receptor binding | Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). |
CFLAR, NOL3, BID, FADD, RIPK1, CASP8, TMBIM1, FEM1B |
GO:0005125 | MF | cytokine activity | Functions to control the survival, growth, differentiation and effector function of tissues and cells. |
TNFRSF11B, TNFSF11, MSTN, GDF9, GREM1, TNFSF13, GDF11, BMP10, IL33, BMP15, TIMP1, TGFB1, TNF, IFNA1 , IL1A, IL1B, IFNA16, INHA, IL6, EDN1, GPI, INHBA, FGF2, HMGB1, INHBB, WNT2, SPP1, BMP2, BMP4, BMP3, CCL4, BMP1, SCG2, MIF, LIF, AREG, VEGFA, IL1RN, IL11, KITLG, BMP6, IL10, SP100, TNFSF4, IL32, GRN, IL12A, CD40LG, BMP8B, WNT5A, GDF5, NAMPT, TNFSF10, INHBC, TGFB2, NDP, NRG1, IL18, ADIPOQ, CTF1, IL34, BMP8A, IFNE, THNSL2, CMTM8, SECTM1, FAM3C, CMTM3, GDF15, GREM2, IL37, CLCF1, TNFSF13B |
GO:0005126 | MF | cytokine receptor binding | Interacting selectively and non-covalently with a cytokine receptor. |
MIF |
GO:0005127 | MF | ciliary neurotrophic factor receptor binding | Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor. |
IL6ST, LIFR, CLCF1 |
GO:0005131 | MF | growth hormone receptor binding | Interacting selectively and non-covalently with the growth hormone receptor. |
SOCS2, JAK2, GH1, JAK1 |
GO:0005132 | MF | type I interferon receptor binding | Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). |
IFNA1 , IFNA16, IFNE |
GO:0005134 | MF | interleukin-2 receptor binding | Interacting selectively and non-covalently with the interleukin-2 receptor. |
TIMM50 |
GO:0005136 | MF | interleukin-4 receptor binding | Interacting selectively and non-covalently with the interleukin-4 receptor. |
PIBF1 |
GO:0005137 | MF | interleukin-5 receptor binding | Interacting selectively and non-covalently with the interleukin-5 receptor. |
SDCBP |
GO:0005138 | MF | interleukin-6 receptor binding | Interacting selectively and non-covalently with the interleukin-6 receptor. |
IL6, IL6R, IL6ST, ADAM17, ERAP1, PYCARD |
GO:0005141 | MF | interleukin-10 receptor binding | Interacting selectively and non-covalently with the interleukin-10 receptor. |
IL10 |
GO:0005142 | MF | interleukin-11 receptor binding | Interacting selectively and non-covalently with the interleukin-11 receptor. |
IL11 |
GO:0005143 | MF | interleukin-12 receptor binding | Interacting selectively and non-covalently with the interleukin-12 receptor. |
JAK2, IL12A, IL12RB1 |
GO:0005146 | MF | leukemia inhibitory factor receptor binding | Interacting selectively and non-covalently with the leukemia inhibitory factor receptor. |
LIF, CTF1 |
GO:0005148 | MF | prolactin receptor binding | Interacting selectively and non-covalently with the prolactin receptor. |
PRL, GH1 |
GO:0005149 | MF | interleukin-1 receptor binding | Interacting selectively and non-covalently with the interleukin-1 receptor. |
TLR5, IL1A, IL1B, TRIP6, IL37 |
GO:0005150 | MF | interleukin-1, Type I receptor binding | Interacting selectively and non-covalently with a Type I interleukin-1 receptor. |
IL1RN, TOLLIP |
GO:0005151 | MF | interleukin-1, Type II receptor binding | Interacting selectively and non-covalently with a Type II interleukin-1 receptor. |
IL1RN, ERAP1 |
GO:0005152 | MF | interleukin-1 receptor antagonist activity | Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. |
IL1RN |
GO:0005153 | MF | interleukin-8 receptor binding | Interacting selectively and non-covalently with the interleukin-8 receptor. |
CXCL8, YARS |
GO:0005154 | MF | epidermal growth factor receptor binding | Interacting selectively and non-covalently with the epidermal growth factor receptor. |
EREG, PLSCR1, SOCS5, SNX4, TGFA, ITGA5, AREG, ARF4, BTC, GRB2, TNK2, EFEMP1, SNX1, ERBB4, HBEGF, RNF126, VAV3 |
GO:0005157 | MF | macrophage colony-stimulating factor receptor binding | Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor. |
IL34 |
GO:0005158 | MF | insulin receptor binding | Interacting selectively and non-covalently with the insulin receptor. |
IRS4, SNX4, INS, IGF2, IGF1, IGF1R, ENPP1, PIK3R1, IRS1, INSL3, PTPN11, GRB10, SNX1, FRS2, PHIP, DOK1, SORBS1, LMBRD1, DOK5, IRS2 |
GO:0005159 | MF | insulin-like growth factor receptor binding | Interacting selectively and non-covalently with the insulin-like growth factor receptor. |
SOCS2, SOCS1, INS, IGF2, IGF1, INSR, PIK3R1, IRS1, GNAS, YWHAH, GNAS |
GO:0005160 | MF | transforming growth factor beta receptor binding | Interacting selectively and non-covalently with the transforming growth factor beta receptor. |
MSTN, GDF9, GDF11, BMP10, BMP15, TGFB1, LRG1, AMH, INHA, INHBA, INHBB, BMP2, BMP4, BMP3, BMP1, BMP6, BMP8B, GDF5, INHBC, TGFB2, SMAD3, TGFBR3, SMAD2, BMP8A, GDF15, RASL11B, SMURF2, USP15 |
GO:0005161 | MF | platelet-derived growth factor receptor binding | Interacting selectively and non-covalently with the platelet-derived growth factor receptor. |
ERN1, PDGFB, PDGFA, ITGB3, LYN, ITGA5, PDGFRB, IL1R1, VEGFA, PDGFRA, PTEN, PTPRJ, PDGFD, PDGFC |
GO:0005163 | MF | nerve growth factor receptor binding | Interacting selectively and non-covalently with the nerve growth factor receptor. |
NGF |
GO:0005164 | MF | tumor necrosis factor receptor binding | Interacting selectively and non-covalently with the tumor necrosis factor receptor. |
TNFSF11, TNFSF13, TRIM37, TNF, TNFSF4, CD40LG, TNFSF10, TRAF1, FADD, CASP8, TRADD, TNFSF13B |
GO:0005166 | MF | neurotrophin p75 receptor binding | Interacting selectively and non-covalently with the neurotrophin p75 receptor. |
NTRK1, ZNF274 |
GO:0005168 | MF | neurotrophin TRKA receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKA receptor. |
PIK3R1, EFNA5, GRB2, FRS2 |
GO:0005169 | MF | neurotrophin TRKB receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKB receptor. |
BDNF, EFNA5 |
GO:0005170 | MF | neurotrophin TRKC receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKC receptor. |
EFNA5 |
GO:0005171 | MF | hepatocyte growth factor receptor binding | Interacting selectively and non-covalently with the hepatocyte growth factor receptor. |
GLMN, ESM1 |
GO:0005172 | MF | vascular endothelial growth factor receptor binding | Interacting selectively and non-covalently with any vascular endothelial growth factor receptor. |
VEGFA, PGF |
GO:0005173 | MF | stem cell factor receptor binding | Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. |
KITLG, SPRED1 |
GO:0005174 | MF | CD40 receptor binding | Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes. |
CD40LG |
GO:0005175 | MF | CD27 receptor binding | Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells. |
SIVA1 |
GO:0005176 | MF | ErbB-2 class receptor binding | Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2. |
CDK5, NRG1, MUC4 |
GO:0005178 | MF | integrin binding | Interacting selectively and non-covalently with an integrin. |
CYR61, PLPP3, ADAM10, ITGB1BP1, TSPAN4, ACTN4, EDIL3, ADAM23, SEMA7A, WISP2, ECM2, WISP1, EGFR, COL3A1, FN1, VTN, VWF, IGF1, ICAM1, ITGB1, P4HB, LYN, THBS1, ITGA5, ACTN1, TIMP2, ITGA2, PTPN2, TSPAN8, VCAM1, COL5A1, CD9, TNXB, ITGA6, ITGA3, CALR, CTGF, THBS4, FBN1, ACTN2, SYK, CD151, MMP14, EMP2, CXADR, ADAM17, COL4A3, NRG1, DST, COL16A1, MFGE8, CDH17, ILK, ADAM9, GPNMB, TGFBI, S1PR3, JAM3, ESM1, ADAMTS5, ADAMTS8, NISCH, TLN1 |
GO:0005179 | MF | hormone activity | The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. |
STC2, BMP10, AGT, GNRH1, POMC, CGA, FSHB, LHB, PRL, GH1, PTH, GCG, INS, IGF2, TTR, AMH, IGF1, CHGB, INHA, EDN1, CCK, INHBA, NMB, INHBB, SCT, CGB5, CGB7, IAPP, PTHLH, NPPB, EDN2, ADM, FBN1, LEP, INSL3, STC1, COPA, INHBC, HAMP, ADIPOQ, RETN, KL, APLN |
GO:0005183 | MF | gonadotropin hormone-releasing hormone activity | The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. |
GNRH1 |
GO:0005184 | MF | neuropeptide hormone activity | The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. |
AGRP, POMC, PENK, CCK, TRH, GAL, NTS, CARTPT, SPX |
GO:0005198 | MF | structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. |
PSMD11, CLDN4, COPE, NPHP1, CLDN3, ROCK2, MPZL1, CLDN1, CSTA, LMNA, FGA, FGB, FGG, BGLAP, ANXA1, KRT1, KRT18, KRT8, TUBB, LAMB1, KRT7, CLTA, MAP2, KRT3, NEFH, KRT13, JUP, DSP, LMNB1, LAMA2, CTNNA1, SPRR2B, GNL1, COL18A1, MATR3, MAP1B, NES, COPA, PLP1, TUBA1B, JAG1, MAP1A, COL4A3, CAV1, LMNB2, IFFO1, ASPH, MAPK8IP2, SNTA1, SNTB2, SNTB1, EIF3A, MAP7, SEPT7, LAMA3, MAP7D1, ODF2, CROCC, KRT80, TUBA1A, BVES, TUBGCP3, ISCA1, SPRR2G, KRT23, PNN, SYNC, SPAG4, CDC42SE2, CDC42SE1, SPRR3, KLHL3, COPG1, LAMC3 |
GO:0005199 | MF | structural constituent of cell wall | The action of a molecule that contributes to the structural integrity of a cell wall. |
JUP |
GO:0005200 | MF | structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
FRMD3, HIP1, NDC80, ARPC2, ARPC3, PPL, SORBS3, SORBS2, YEATS4, TUBB4A, TUBB, VIM, KRT19, KRT16, TPM1, MAPT, DMD, NEFH, DSP, DES, TUBG1, CTNNA2, KRT9, ARPC4, ACTB, ACTR3, ACTR2, ACTG1, TUBA1B, TUBA4A, TUBB4B, SPTBN1, ANK2, KRT17, ANK3, TUBB3, TUBA3C, TUBB2A, PLS1, CCDC6, TUBA1A, TUBGCP3, BICD1, FRMD6, TUBB6, TUBB2B, SPTBN4, EPB41L4B, TUBB1, EPB41L1, EPB41L4A, ADD3, TUBE1, TUBD1, EPB41L3, TLN1 |
GO:0005201 | MF | extracellular matrix structural constituent | The action of a molecule that contributes to the structural integrity of the extracellular matrix. |
NCAN, TECTA, EFEMP2, CD4, COL1A1, COL3A1, COL5A2, LAMB1, COL1A2, MGP, COL4A2, HAPLN1, LAMC1, COL11A1, VCAN, COL5A1, BGN, FBLN1, ANOS1, COL8A2, COL5A3, FBN1, FBN2, CHI3L1, COL15A1, TFPI2, COMP, LUM, MUC5AC, FBLN2, COL4A3, MUC3A, COL14A1, MFAP5, COL4A6, LAMA4, FBN3, BCAN, TINAGL1, DSPP |
GO:0005212 | MF | structural constituent of eye lens | The action of a molecule that contributes to the structural integrity of the lens of an eye. |
CRYAB, VIM, MIP, CPOX |
GO:0005215 | MF | transporter activity | Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. |
FABP12, AP3D1, GOSR2, XPO1, ATP6V0E1, ASNA1, SLC37A4, NUP155, RASSF9, SEC14L2, KIF20A, PMP2, RBP1, IGF2R, FABP4, SYN1, ATP5J, ATP6V1C1, ATP5D, MIP, GABRA5, ABCC1, PTGDS, ATP5O, ATP5G3, FABP6, AP2S1, UCP3, LCN2, FABP5, ATP5G2, AP1B1, CDH17, TCOF1, TCIRG1, MFSD14B, SYPL2, SLC23A3, SLC51A, SLC16A10, SCARB1, AQP3, AP2M1, SEC22A, MFSD14A, NUP88, CHP1, TTPAL, TMEM245, STARD7, ABCB10, ABCF2, SLC25A13, VPS9D1, AP4S1 |
GO:0005216 | MF | ion channel activity | Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). |
KCNK3, GJC1, SCNN1G, TRPV2 |
GO:0005219 | MF | ryanodine-sensitive calcium-release channel activity | Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. |
RYR3, RYR2 |
GO:0005220 | MF | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts. |
ITPR2, ITPR3, ITPR1 |
GO:0005222 | MF | intracellular cAMP activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. |
CNGA1 |
GO:0005223 | MF | intracellular cGMP activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. |
CNGA1 |
GO:0005224 | MF | ATP-binding and phosphorylation-dependent chloride channel activity | Enables the transmembrane transfer of a chloride ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. |
CFTR |
GO:0005225 | MF | volume-sensitive anion channel activity | Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. |
LRRC8A, LRRC8C |
GO:0005227 | MF | calcium activated cation channel activity | Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
ANO6, TRPM4 |
GO:0005229 | MF | intracellular calcium activated chloride channel activity | Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
BEST1, CLCA4, ANO6, ANO2 |
GO:0005230 | MF | extracellular ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. |
GABRA5, CHRNA7, CHRFAM7A, TRPV1 |
GO:0005231 | MF | excitatory extracellular ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels. |
GRIA4, TRPV1 |
GO:0005234 | MF | extracellular-glutamate-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
GRIA4, GRIN2A |
GO:0005242 | MF | inward rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. |
KCNK1, KCNH2, KCNJ12, KCNK6 |
GO:0005243 | MF | gap junction channel activity | A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. |
GJA1, MIP, GJC1 |
GO:0005244 | MF | voltage-gated ion channel activity | Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
GPR89A, CLIC1, CLIC3, CYBB, GPR89B, PKD2, ANO6, TMEM37, CLIC6, KCNK17, KCNK12, CLIC5 |
GO:0005245 | MF | voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
ITGAV, CACNB3, CACNA2D1, NCS1, PKD2, CACNA1C, GAS6, CACNA1E, TPCN2, CACNG8, CACNG6 |
GO:0005246 | MF | calcium channel regulator activity | Modulates the activity of a calcium channel. |
TSPAN13, PRKCB, PLN, SRI, NPY2R, GNB2, GRM3, SGK3, STIM2, NRXN1, HPCAL4 |
GO:0005247 | MF | voltage-gated chloride channel activity | Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
CLCN3, CLCN4, CLCN5, CLCN6, CLCN7, CLCNKA, CLCNKB, ANO6 |
GO:0005248 | MF | voltage-gated sodium channel activity | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
PKD2, SCN9A |
GO:0005249 | MF | voltage-gated potassium channel activity | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
CNGA1, KCNA1, KCNMA1, KCNH2, KCNC3, KCNJ11, KCNE4 |
GO:0005250 | MF | A-type (transient outward) potassium channel activity | Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential. |
KCNIP2 |
GO:0005251 | MF | delayed rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. |
KCNA1, KCNH2, KCNC3, KCNG3, KCNV2, KCNG1 |
GO:0005252 | MF | open rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration. |
KCNK3 |
GO:0005253 | MF | anion channel activity | Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. |
LRRC8A |
GO:0005254 | MF | chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
FXYD1, CLIC1, BEST1, CLIC3, CFTR, GABRA5, SLC1A4, SLC26A2, CLCN3, CLCN4, CLCN5, CLCN7, CLCA4, SLC26A11, BEST3, CLIC6, SLC26A1, TTYH1, CLIC5 |
GO:0005260 | MF | channel-conductance-controlling ATPase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. |
CFTR |
GO:0005261 | MF | cation channel activity | Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
TRPC1, FAM26F, PIEZO1, CALHM2, TRPV4, GAR1, ASIC3, TRPV2 |
GO:0005262 | MF | calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
TRPC1, PSEN1, CACNB3, PKD1, GRIN2A, TRPC3, CACNA1E, DENND5A, DENND5B, TRPV1, TRPM4, TMEM37, RYR2, CUL5, TRPM7, PANX1, TRPM6, TRPV6, TRPV4, SLC24A3, TMCO1, TRPC6, TRPV2 |
GO:0005267 | MF | potassium channel activity | Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
KCNK1, KCNK3, FXYD4, KCNA1, PKD2, KCNK17, TMEM38B, KCNG1, KCNK6 |
GO:0005272 | MF | sodium channel activity | Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
KCNK1, SCNN1G, TRPM4, ASIC3 |
GO:0005275 | MF | amine transmembrane transporter activity | Enables the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. |
AQP9 |
GO:0005277 | MF | acetylcholine transmembrane transporter activity | Enables the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. |
SLC22A1 |
GO:0005280 | MF | hydrogen:amino acid symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). |
SLC36A1 |
GO:0005283 | MF | sodium:amino acid symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). |
SLC38A1 |
GO:0005289 | MF | high-affinity arginine transmembrane transporter activity | Catalysis of the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
SLC7A2 |
GO:0005290 | MF | L-histidine transmembrane transporter activity | Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
SLC38A1 |
GO:0005292 | MF | high-affinity lysine transmembrane transporter activity | Catalysis of the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
SLC7A2 |
GO:0005308 | MF | creatine transmembrane transporter activity | Enables the directed movement of creatine across a membrane. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. |
SLC6A8, SLC16A12 |
GO:0005309 | MF | creatine:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). |
SLC6A8 |
GO:0005310 | MF | dicarboxylic acid transmembrane transporter activity | Enables the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. |
SLC25A10 |
GO:0005313 | MF | L-glutamate transmembrane transporter activity | Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. |
SLC25A12, SLC1A3, SLC1A2, SLC25A13 |
GO:0005314 | MF | high-affinity glutamate transmembrane transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
SLC1A3, SLC1A2, SLC1A6 |
GO:0005315 | MF | inorganic phosphate transmembrane transporter activity | Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
SLC20A2, SLC20A1, ANKH |
GO:0005316 | MF | high-affinity inorganic phosphate:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
SLC20A1 |
GO:0005319 | MF | lipid transporter activity | Enables the directed movement of lipids into, out of or within a cell, or between cells. |
APOE, APOA2, APOD, GM2A, SLCO2A1 |
GO:0005324 | MF | long-chain fatty acid transporter activity | Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
FABP3, ABCD3 |
GO:0005328 | MF | neurotransmitter:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). |
SLC6A1, SLC6A6, SLC6A8, SLC6A14 |