| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0004728 | MF | receptor signaling protein tyrosine phosphatase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
MAP2K1 |
GO:0004731 | MF | purine-nucleoside phosphorylase activity | Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. |
PNP |
GO:0004735 | MF | pyrroline-5-carboxylate reductase activity | Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. |
PYCRL |
GO:0004736 | MF | pyruvate carboxylase activity | Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate. |
PC |
GO:0004738 | MF | pyruvate dehydrogenase activity | Catalysis of the oxidative decarboxylation of pyruvate. |
PDHA1, PDHB |
GO:0004739 | MF | pyruvate dehydrogenase (acetyl-transferring) activity | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. |
PDHA1, PDHB |
GO:0004740 | MF | pyruvate dehydrogenase (acetyl-transferring) kinase activity | Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. |
PDK1, PDK4 |
GO:0004741 | MF | [pyruvate dehydrogenase (lipoamide)] phosphatase activity | Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate. |
PDP1 |
GO:0004742 | MF | dihydrolipoyllysine-residue acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. |
DLAT |
GO:0004743 | MF | pyruvate kinase activity | Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. |
PKM |
GO:0004745 | MF | retinol dehydrogenase activity | Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. |
HSD17B6, DHRS3, BMP2, ADH7, AKR1C3, RDH10, RDH11, DHRS9 |
GO:0004748 | MF | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. |
RRM1, RRM2 |
GO:0004749 | MF | ribose phosphate diphosphokinase activity | Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). |
PRPS2, PRPS1 |
GO:0004756 | MF | selenide, water dikinase activity | Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate. |
SEPHS1 |
GO:0004758 | MF | serine C-palmitoyltransferase activity | Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA. |
SPTLC2, SPTSSB |
GO:0004760 | MF | serine-pyruvate transaminase activity | Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. |
AGXT |
GO:0004766 | MF | spermidine synthase activity | Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. |
SRM |
GO:0004767 | MF | sphingomyelin phosphodiesterase activity | Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). |
SMPD4 |
GO:0004768 | MF | stearoyl-CoA 9-desaturase activity | Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O. |
SCD, FADS2, SCD5 |
GO:0004769 | MF | steroid delta-isomerase activity | Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. |
HSD3B1, HSD3B2, EBP |
GO:0004771 | MF | sterol esterase activity | Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. |
LIPA |
GO:0004772 | MF | sterol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester. |
SOAT1 |
GO:0004773 | MF | steryl-sulfatase activity | Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. |
STS |
GO:0004775 | MF | succinate-CoA ligase (ADP-forming) activity | Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. |
SUCLG1, SUCLA2 |
GO:0004776 | MF | succinate-CoA ligase (GDP-forming) activity | Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. |
SUCLG1 |
GO:0004778 | MF | succinyl-CoA hydrolase activity | Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate. |
ACOT4 |
GO:0004781 | MF | sulfate adenylyltransferase (ATP) activity | Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. |
PAPSS2 |
GO:0004782 | MF | sulfinoalanine decarboxylase activity | Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. |
CSAD |
GO:0004784 | MF | superoxide dismutase activity | Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. |
CCS, SOD2, SOD3, NQO1 |
GO:0004788 | MF | thiamine diphosphokinase activity | Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. |
TPK1 |
GO:0004791 | MF | thioredoxin-disulfide reductase activity | Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide. |
TXNRD1 |
GO:0004792 | MF | thiosulfate sulfurtransferase activity | Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate. |
MPST |
GO:0004797 | MF | thymidine kinase activity | Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. |
TK2, TK1 |
GO:0004798 | MF | thymidylate kinase activity | Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. |
DTYMK, CMPK2 |
GO:0004799 | MF | thymidylate synthase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. |
TYMS |
GO:0004800 | MF | thyroxine 5'-deiodinase activity | Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. |
DIO2 |
GO:0004801 | MF | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity | Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. |
TALDO1 |
GO:0004802 | MF | transketolase activity | Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. |
TKT |
GO:0004803 | MF | transposase activity | Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. |
ZBED1 |
GO:0004806 | MF | triglyceride lipase activity | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. |
LPL, AADAC, LIPE, PNPLA5, PNPLA2, PNPLA3 |
GO:0004807 | MF | triose-phosphate isomerase activity | Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. |
TPI1 |
GO:0004810 | MF | tRNA adenylyltransferase activity | Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1). |
TRNT1 |
GO:0004814 | MF | arginine-tRNA ligase activity | Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). |
RARS |
GO:0004815 | MF | aspartate-tRNA ligase activity | Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). |
DARS |
GO:0004818 | MF | glutamate-tRNA ligase activity | Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). |
EPRS, EARS2 |
GO:0004821 | MF | histidine-tRNA ligase activity | Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). |
HARS, HARS2 |
GO:0004823 | MF | leucine-tRNA ligase activity | Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu). |
LARS2 |
GO:0004824 | MF | lysine-tRNA ligase activity | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
KARS |
GO:0004826 | MF | phenylalanine-tRNA ligase activity | Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
FARS2, FARSA |
GO:0004827 | MF | proline-tRNA ligase activity | Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). |
EPRS, PARS2 |
GO:0004828 | MF | serine-tRNA ligase activity | Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). |
SARS |
GO:0004829 | MF | threonine-tRNA ligase activity | Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). |
TARS |
GO:0004831 | MF | tyrosine-tRNA ligase activity | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). |
YARS |
GO:0004832 | MF | valine-tRNA ligase activity | Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). |
YARS |
GO:0004835 | MF | tubulin-tyrosine ligase activity | Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. |
TTL |
GO:0004839 | MF | ubiquitin activating enzyme activity | Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. |
UBA6, UBA1, UBA7, SAE1 |
GO:0004842 | MF | ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
ASB14, RNF103, WWP2, PEX12, UBE2C, BACH1, BIRC5, SIAH2, PARK2, TRIM13, FBXO24, RNF8, TRIM37, UBR5, CNOT4, RAG1, TNFAIP3, UBA1, TRIM23, BRCA1, UBA7, CDC34, UBE2A, UBE2E1, TTC3, UBE2D3, UBE2M, UBE2H, RBX1, UBE2B, SKP1, XIAP, MDM2, CBLB, TRIM28, SKP2, BIRC3, CUL3, TRIM25, SHPRH, HERC3, TCEB1, UBE3C, UBE2S, LONRF1, KLHL12, HERC4, MARCH8, UBR4, HECTD2, FBXO31, RFWD3, KLHL24, CYHR1, PDZRN4, RNF19B, UBR3, CBLL1, MAEA, RNF144B, RBBP6, HUWE1, TRIM69, RNF130, MIB1, SIAH1, KLHL7, KBTBD2, KLHDC8A, HACE1, KLHL36, RNF182, RNF152, KLHL23, FBXO22, FBXO25, MARCH1, RNF141, MYLIP, KCTD13, CUL5, FBXO32, UBE2E3, MIB2, UBE2W, KLHDC7B, RMND5B, ITCH, ZFP91, UBE2E2, KLHL15, KLHL32, ASB16, KLHL5, UHRF2, NEDD4L, UHRF1, MPHOSPH8, BARD1, FEM1A, TRIM62, BACH2, TRIM9, TRIM2, KLHL4, RNF38, WWP1, KCTD10, FBXL15, RMND5A, SMURF2, RC3H2, UBE2T, RNF146, RNF19A, RLIM, RNF216, KLHL28, DTL, RNF181, KLHL8, KLHL9, KLHL42, KLHL13, HECW2, KLHL3, MKRN1, FBXL7, CDC23, ANAPC4, FEM1B, FBXO10, FBXO9, FBXL2, AMFR, STUB1, TRIM33, PDZRN3, RNF6, BTRC, UBE2D4, ARIH1, RNF114, ASB3 |
GO:0004843 | MF | thiol-dependent ubiquitin-specific protease activity | Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. |
USP27X, USP12, USP2, USP1, STAMBP, UCHL1, UCHL3, TNFAIP3, USP6, BRCC3, USP11, ATXN3, USP46, JOSD1, OTUD1, OTUD7B, USP34, USP31, USP51, USP45, USP48, USP32, BAP1, TANK, UFD1L, USP13, OTUB2, OTUB1, VCPIP1, USP28, USP44, USP42, CYLD, USP36, USP35, ZRANB1, USP25, USP22, USP20, USP15, UCHL5 |
GO:0004844 | MF | uracil DNA N-glycosylase activity | Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. |
UNG, TDG, SMUG1 |
GO:0004849 | MF | uridine kinase activity | Catalysis of the reaction: ATP + uridine = ADP + UMP. |
CMPK1, UPRT, UCK2, UCK1, UCKL1 |
GO:0004850 | MF | uridine phosphorylase activity | Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. |
UPP2, UPP1 |
GO:0004853 | MF | uroporphyrinogen decarboxylase activity | Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. |
UROD |
GO:0004854 | MF | xanthine dehydrogenase activity | Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. |
XDH, AOX1 |
GO:0004855 | MF | xanthine oxidase activity | Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide. |
XDH |
GO:0004857 | MF | enzyme inhibitor activity | Binds to and stops, prevents or reduces the activity of an enzyme. |
PPP1R12A, SCG5, PLN, NOTCH1, FRY, CCAR2, TXNIP |
GO:0004859 | MF | phospholipase inhibitor activity | Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. |
APOC1, ANXA5, ANXA4, PDC |
GO:0004860 | MF | protein kinase inhibitor activity | Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. |
SOCS2, SOCS3, SOCS6, SOCS1, FLRT2, SH3BP5, SOCS5, NPM1, DCN, BGN, DNAJC3, SH3BP5L, PODN, RTN4RL1, LRRTM4, DUSP19, TRIB2, TRIB3, TRIB1, CHP1, TAOK3, LRRC19, FLRT3, FLRT1, MAPK8IP1 |
GO:0004861 | MF | cyclin-dependent protein serine/threonine kinase inhibitor activity | Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. |
HEXIM1, CDKN1A, CDKN2B, CDKN2C, CDKN1B, CDKN1C, KAT2B |
GO:0004862 | MF | cAMP-dependent protein kinase inhibitor activity | Stops, prevents or reduces the activity of a cAMP-dependent protein kinase. |
PRKAR1A, PRKAR2A, PRKAR2B, PKIA, PKIG |
GO:0004864 | MF | protein phosphatase inhibitor activity | Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. |
ENSA, PHACTR2, URI1, ARPP19, SET, PPP1R35, SH3RF2, PPP1R10, PPME1, CABIN1 |
GO:0004865 | MF | protein serine/threonine phosphatase inhibitor activity | Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. |
PPP1R11, PPP1R2, PPP1R1A, PPP1R14C, PPP1R14A, PPP1R14B |
GO:0004866 | MF | endopeptidase inhibitor activity | Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
SPINT2, RECK, SPINK1, C3, CST3, AHSG, SLPI, CSTB, C4A, C4B, TFPI, CAST, SPP2, WFDC2, PROL1, UCHL5 |
GO:0004867 | MF | serine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
SPINT2, PAPLN, RECK, SPINK1, SERPINC1, SERPINA1, SERPINA3, AGT, A2M, AMBP, SLPI, APP, SERPINE1, SERPINA5, SERPING1, SERPINE2, FURIN, TFPI, COL6A3, ANOS1, SERPINB3, PEBP1, SERPINB1, SERPINB5, SERPINF1, TFPI2, SERPINB4, SERPINB9, SERPINH1, APLP2, WFDC2, ITIH5, WFDC3, SERPINA12, CPAMD8, SERPINI1, WFDC1, CRIM1, SERPINB13 |
GO:0004869 | MF | cysteine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
BIRC5, PTTG1, CST3, CSTA, KNG1, AHSG, CSTB, CST2, CAST, SERPINB3, WFDC2, CARD16, FETUB, SERPINB13 |
GO:0004871 | MF | signal transducer activity | Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
GPR89A, AIP, TRIM38, IRS4, PPP1R12A, AXIN1, RIPK2, TSPAN6, GNG7, TRIM13, PLEKHG5, DKK1, IKBKAP, GNAI2, S100A9, NGFR, GNAI3, LGALS1, HMOX1, GPR89B, IL1R1, JUP, GNB3, PLCG2, STMN1, GJA1, FST, CAPN3, FLNA, ZP3, CXCR2, CD24, FAS, EEF1D, GNA11, LSP1, CTNNB1, IRS1, CHKA, STAT3, STAT5A, CRKL, MAPKAPK2, RGS7, GNAQ, GNG4, PLCD1, STAT5B, STAT2, YARS, GNG11, GNB1, GNB2, GNAI1, GNG5, GNAS, ATP2C1, GNA12, PTK2, PLCXD2, BST2, AKAP13, CBLB, ITGB3BP, ILK, GAB1, PLCL1, TRADD, GNAS, WLS, PLCXD3, CSPG4, CXXC5, MAVS, TMED4, MAGI2, ZDHHC17, SLC44A2, C18orf32, SLC20A1, SECTM1, TFG, CREBBP, MIB2, LITAF, NDFIP1, TOLLIP, ECT2, SP110, NEK6, IL1RAP, PLCB1, SH2B1, NDFIP2, PLK2, VAPA, KL, PLEKHB1, CNOT7, SUFU, PLCL2, SH2B3, GOLT1B, IRS2 |
GO:0004872 | MF | receptor activity | Combining with an extracellular or intracellular messenger to initiate a change in cell activity. |
TLR4, TNFRSF11B, NPC1, TLR3, MED14, LY75, NRP2, TLR5, TLR2, RAMP1, RAMP3, LDLR, CD4, OPN1SW, KRT1, ICAM1, NGFR, CD48, IGF2R, PVR, FOLR1, CD46, CD1D, ITGB4, CD33, CHRM3, ITGAX, MRC1, FAS, ITGB8, GABRA5, CD200, ADCYAP1R1, NOTCH1, NPY2R, F2RL1, ANTXR2, FKBP3, TEK, GUCY2D, PLAUR, NOTCH2, IL10RB, SLC20A2, SMAGP, IL18R1, TLR1, MMD, SLC1A5, AMHR2, AMOT, JMJD6, SV2A, RTN4RL1, PKHD1L1, NLGN4X, NLGN1, SLC20A1, CUL5, TNFRSF25, MED12, MED30, CSF3R, SEC62, VIMP, CADM1, CD244, SLC40A1, TREM1, MED4, CD93, NECTIN3, TNFRSF19, MED17, RRBP1, SEC63, PLXNA1, AMFR, NRXN1, PROCR, SIGLEC7, THRAP3, MED16, TNPO3, LYVE1, TNFRSF11A |
GO:0004873 | MF | asialoglycoprotein receptor activity | Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane. |
LRPAP1 |
GO:0004874 | MF | aryl hydrocarbon receptor activity | Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding. |
ARNT, AHR |
GO:0004875 | MF | complement receptor activity | Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
GPR32, FPR1, FPR2 |
GO:0004877 | MF | complement component C3b receptor activity | Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
CR1 |
GO:0004878 | MF | complement component C5a receptor activity | Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
C5AR1 |
GO:0004879 | MF | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
NR5A2, AR, NR2F1, ESRRA, NR1D1, NR4A1, NR2F2, RXRB, RORA, AHR, PPARG, STAT3, NR4A2, NR0B1, NR1H2, PPARD, PPARA, NR1H3, NR1D2, GLMP, ESR2, NR1H4 |
GO:0004882 | MF | androgen receptor activity | Combining with an androgen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an androgen response element in DNA in order to modulate transcription by RNA polymerase II. |
AR |
GO:0004883 | MF | glucocorticoid receptor activity | Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function. |
NR3C1 |
GO:0004886 | MF | 9-cis retinoic acid receptor activity | Combining with 9-cis retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
RXRB |
GO:0004887 | MF | thyroid hormone receptor activity | Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
THRA, NR4A3, NR1H4 |
GO:0004888 | MF | transmembrane signaling receptor activity | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
TLR4, CLDN4, TNFRSF10C, NPC1, TLR3, CLDN3, LY75, TLR5, TLR2, LGR5, EGFR, CD4, ERBB2, ICAM1, NGFR, GP1BB, IL1R1, SELE, LAG3, ERBB3, EVI2A, MRC1, KLRC1, CD27, TNFRSF8, LEPR, CD97, BCAM, PLXNA3, SCARF1, EBP, TLR1, TRPV1, DNER, SORL1, LGR4, LGR6, INTS6, LYVE1, TNFRSF11A |
GO:0004889 | MF | acetylcholine-activated cation-selective channel activity | Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. |
CHRNB1, CHRNA5, CHRNA7 |
GO:0004890 | MF | GABA-A receptor activity | Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. |
GABRA5 |
GO:0004896 | MF | cytokine receptor activity | Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
CD74, GHR, CD44, IL12RB1, IL1RL1, CSF3R, IL17RB |
GO:0004897 | MF | ciliary neurotrophic factor receptor activity | Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL6R, IL6ST, LIFR |
GO:0004900 | MF | erythropoietin receptor activity | Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
EPOR |
GO:0004905 | MF | type I interferon receptor activity | Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. |
IFNAR1, IFNAR2 |
GO:0004906 | MF | interferon-gamma receptor activity | Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IFNGR1, IFNGR2 |
GO:0004908 | MF | interleukin-1 receptor activity | Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. |
IL1R1, IL1R2, IL1RL1, IL18R1, IL1RAP |
GO:0004909 | MF | interleukin-1, Type I, activating receptor activity | Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. |
IL1R1 |
GO:0004910 | MF | interleukin-1, Type II, blocking receptor activity | Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors. |
IL1R2 |
GO:0004913 | MF | interleukin-4 receptor activity | Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL4R |
GO:0004914 | MF | interleukin-5 receptor activity | Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL5RA |
GO:0004915 | MF | interleukin-6 receptor activity | Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL6R, IL6ST |