| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0004565 | MF | beta-galactosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. |
GLB1L2 |
GO:0004566 | MF | beta-glucuronidase activity | Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. |
KL, HPSE |
GO:0004568 | MF | chitinase activity | Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. |
CTBS, CHIT1 |
GO:0004569 | MF | glycoprotein endo-alpha-1,2-mannosidase activity | Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane. |
MANEA, EDEM3 |
GO:0004571 | MF | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. |
MAN1A1, EDEM1, EDEM3, MAN1C1, MAN1B1 |
GO:0004572 | MF | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity | Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). |
MAN2A2 |
GO:0004574 | MF | oligo-1,6-glucosidase activity | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. |
GAA |
GO:0004576 | MF | oligosaccharyl transferase activity | Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
DDOST, DAD1 |
GO:0004577 | MF | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol. |
ALG13 |
GO:0004579 | MF | dolichyl-diphosphooligosaccharide-protein glycotransferase activity | Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. |
DDOST, STT3A, DAD1, STT3B, OSTC |
GO:0004582 | MF | dolichyl-phosphate beta-D-mannosyltransferase activity | Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. |
DPM3 |
GO:0004583 | MF | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity | Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide. |
ALG10B, ALG8, ALG6 |
GO:0004586 | MF | ornithine decarboxylase activity | Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine. |
ODC1 |
GO:0004588 | MF | orotate phosphoribosyltransferase activity | Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. |
UMPS |
GO:0004590 | MF | orotidine-5'-phosphate decarboxylase activity | Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP. |
UMPS |
GO:0004591 | MF | oxoglutarate dehydrogenase (succinyl-transferring) activity | Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. |
MRPS36, OGDH |
GO:0004594 | MF | pantothenate kinase activity | Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. |
PANK2, PANK3 |
GO:0004595 | MF | pantetheine-phosphate adenylyltransferase activity | Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate. |
COASY |
GO:0004596 | MF | peptide alpha-N-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein. |
NAA30, NAA25, NAA15, NAA50, NAA60 |
GO:0004597 | MF | peptide-aspartate beta-dioxygenase activity | Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2. |
ASPH |
GO:0004598 | MF | peptidylamidoglycolate lyase activity | Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate. |
PAM |
GO:0004601 | MF | peroxidase activity | Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. |
MGST3, MPO, PTGS1, PTGS2, HBB, HBA1, PRDX1, GPX8, CYGB, IPCEF1, GPX7, DUOX2, DUOX1 |
GO:0004602 | MF | glutathione peroxidase activity | Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. |
MGST3, GSTZ1, GPX1, GSTA1, GSTP1, MGST1, GPX3, GSTM2, PRDX6, GSTT1, GPX4, GPX8, GPX7, MGST2, GSTK1 |
GO:0004603 | MF | phenylethanolamine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine. |
PNMT |
GO:0004605 | MF | phosphatidate cytidylyltransferase activity | Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
CDS2, CDS1 |
GO:0004608 | MF | phosphatidylethanolamine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine. |
PEMT |
GO:0004611 | MF | phosphoenolpyruvate carboxykinase activity | Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products. |
PCK2 |
GO:0004613 | MF | phosphoenolpyruvate carboxykinase (GTP) activity | Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2. |
PCK1, PCK2 |
GO:0004614 | MF | phosphoglucomutase activity | Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. |
PGM1, PGM2 |
GO:0004615 | MF | phosphomannomutase activity | Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. |
PMM2 |
GO:0004616 | MF | phosphogluconate dehydrogenase (decarboxylating) activity | Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. |
HIBADH, PGD, GLYR1 |
GO:0004617 | MF | phosphoglycerate dehydrogenase activity | Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. |
PHGDH |
GO:0004618 | MF | phosphoglycerate kinase activity | Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+). |
PGK1 |
GO:0004619 | MF | phosphoglycerate mutase activity | Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. |
PGAM1 |
GO:0004620 | MF | phospholipase activity | Catalysis of the hydrolysis of a glycerophospholipid. |
LPL, LIPH, ABHD6, LIPG |
GO:0004621 | MF | glycosylphosphatidylinositol phospholipase D activity | Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol. |
GPLD1 |
GO:0004622 | MF | lysophospholipase activity | Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. |
LYPLA1, PLA2G4A, ENPP2, ABHD12, MGLL, PNPLA8, LGALS13, PLA2G4C |
GO:0004623 | MF | phospholipase A2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. |
PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, PAFAH1B2, PAFAH1B3, PLA2G12A, PNPLA8, PNPLA3, PLA2G4C |
GO:0004629 | MF | phospholipase C activity | Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. |
PLCG2, PDIA3, ADORA1, PLCL1 |
GO:0004630 | MF | phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
HMOX1, GPLD1, PLD1 |
GO:0004634 | MF | phosphopyruvate hydratase activity | Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. |
ENO1, ENO2, ENO3 |
GO:0004637 | MF | phosphoribosylamine-glycine ligase activity | Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. |
GART |
GO:0004638 | MF | phosphoribosylaminoimidazole carboxylase activity | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). |
PAICS |
GO:0004639 | MF | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate. |
PAICS |
GO:0004641 | MF | phosphoribosylformylglycinamidine cyclo-ligase activity | Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate. |
GART |
GO:0004642 | MF | phosphoribosylformylglycinamidine synthase activity | Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate. |
PFAS |
GO:0004644 | MF | phosphoribosylglycinamide formyltransferase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. |
GART |
GO:0004645 | MF | phosphorylase activity | Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. |
TYMP, MTAP |
GO:0004647 | MF | phosphoserine phosphatase activity | Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate. |
DUSP26 |
GO:0004648 | MF | O-phospho-L-serine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. |
PSAT1 |
GO:0004651 | MF | polynucleotide 5'-phosphatase activity | Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. |
DUSP11 |
GO:0004652 | MF | polynucleotide adenylyltransferase activity | Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. |
PAPOLA, PAPD4, PAPD5, PAPOLG, MTPAP |
GO:0004653 | MF | polypeptide N-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. |
GALNT2, GALNT1, GALNT5, GALNT7, GALNT10, GALNT15, GALNT4, GALNT14 |
GO:0004654 | MF | polyribonucleotide nucleotidyltransferase activity | Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate. |
PNPT1 |
GO:0004655 | MF | porphobilinogen synthase activity | Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. |
ALAD |
GO:0004656 | MF | procollagen-proline 4-dioxygenase activity | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. |
P4HA2, P4HB, P4HA1 |
GO:0004657 | MF | proline dehydrogenase activity | Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. |
PRODH |
GO:0004658 | MF | propionyl-CoA carboxylase activity | Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. |
PCCA |
GO:0004661 | MF | protein geranylgeranyltransferase activity | Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. |
PGGT1B |
GO:0004662 | MF | CAAX-protein geranylgeranyltransferase activity | Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. |
PGGT1B |
GO:0004663 | MF | Rab geranylgeranyltransferase activity | Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. |
CHM, RABGGTB |
GO:0004666 | MF | prostaglandin-endoperoxide synthase activity | Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. |
PTGS1, PTGS2 |
GO:0004667 | MF | prostaglandin-D synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). |
PTGDS |
GO:0004668 | MF | protein-arginine deiminase activity | Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3. |
PADI4 |
GO:0004671 | MF | protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. |
ICMT |
GO:0004672 | MF | protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
CDC7, CHEK1, AURKA, DCLK1, MAP3K7, BUB1, BUB1B, JAK2, RPS6KA5, STK17B, RAF1, CDK1, CCL3, CCL2, CCL5, PDGFRA, PRKCA, ERCC2, NPR2, MAK, CDK11B, CAD, LTK, AKT1, GTF2H1, ADRBK2, TGFBR1, PRKCI, ABL2, SYK, SOX9, CSNK1A1, CSNK1D, PIK3CG, MAPKAPK2, CDK8, CSNK1E, GSK3B, CDK7, IRAK1, NEK2, PLK1, DAPK1, PRKAG1, PRKAA2, EPHA4, PRKDC, CCL8, CDK5, MAP2K1, TEK, GUCY2D, PRKCQ, ACVR1, PTK2, PRKCD, RNASEL, STK4, MAP2K5, PAK2, TRIM28, PTK7, PRPF4B, RIPK1, GTF2H2, CDK13, PDK1, MMD, PKN1, PKN2, PDK4, PAN3, NEK10, SGK223, MAP4K3, TEX14, MINK1, PIK3C3, GSG2, GTF2H4, TBRG4, SGK3, NEK1, SMG1, SRPK1, PIK3R4, PKMYT1, MAP3K5, VRK1, PINK1, WNK3, PRKD2, HIPK2, WNK1, CDK12, NLK, TBK1, TNIK, CDK11A, AKT3, MAP4K5, CDC42BPB, STK24, CSNK1G3 |
GO:0004673 | MF | protein histidine kinase activity | Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. |
NME2 |
GO:0004674 | MF | protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
CDC7, PLK4, RIOK3, CHEK1, CASK, AURKA, MAST4, DCLK1, MAPK13, IRAK2, MAP3K13, DAPK3, MAP3K7, RIPK2, BUB1, NUAK1, CCNT1, BUB1B, CCNT2, ROCK2, ULK1, ERN1, RPS6KA5, PAK3, STK17B, MAP4K4, LATS1, RAF1, PRKCB, CDK1, BCR, PSKH1, PRKCA, PRKACA, CDK11B, NME2, CDK2, ACVR2A, MAPK3, MAPK1, AKT1, AKT2, TTK, GRK5, MAP2K2, BMPR1A, ACVR1B, TGFBR1, MAP3K8, PRKCI, PIK3CA, SYK, MAPK8, CSNK1A1, CSNK1D, PIK3CG, MAPKAPK2, CDK8, CSNK1E, CLK2, GSK3B, CDK7, IRAK1, NEK2, NEK3, NEK4, PLK1, DAPK1, LIMK2, PRKAA2, SIK1, SRPK2, PRKDC, CDK5, CDK16, MAP2K1, PRKCQ, ACVR1, PRKCD, TNK2, DMPK, STK4, MAPK7, PAK2, ILK, SQSTM1, PRPF4B, RIPK1, CAMK2D, ACVR2B, FASTK, MELK, PRKD1, STK38, RPS6KA2, RPS6KA1, TESK1, STK11, PKN1, PKN2, MAPK14, AAK1, SBK1, CDC42BPA, MAST2, DSTYK, AATK, NEK10, NEK8, STK32C, MAP4K3, FAM20C, MINK1, STKLD1, ANKK1, NEK11, UHMK1, OSR1, NEK9, STK35, NEK7, TTN, DYRK2, SGK3, ULK4, AURKB, MASTL, PBK, MARK4, SMG1, ALPK1, TRPM7, PASK, TP53RK, SRPK1, PIK3R4, PKMYT1, MAP3K5, VRK1, MKNK1, TRPM6, PINK1, WNK3, PRKD2, SIK2, TAOK3, HIPK2, WNK1, CLK4, MKNK2, NEK6, CSNK1G1, LATS2, SNX15, NRBP2, BMP2K, ZAK, PLK2, MARK1, EIF2AK4, NLK, TBK1, TNIK, TLK1, TAOK2, CDK11A, AKT3, STK38L, SIK3, CAB39, MAP4K5, CDC42BPB, IRAK3, STK24, CSNK1G3 |
GO:0004675 | MF | transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
ACVR2A, BMPR1A, ACVR1B, TGFBR2, ACVR1 |
GO:0004677 | MF | DNA-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA. |
HMGA2, PRKDC, XRCC6BP1 |
GO:0004679 | MF | AMP-activated protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. |
PRKAG1, PRKAA2, PRKAG3 |
GO:0004683 | MF | calmodulin-dependent protein kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin. |
ITPKA, MAPKAPK2, DAPK1, CAMK2D, CAMK1, PNCK, CAMK1D, MKNK1, MKNK2 |
GO:0004687 | MF | myosin light chain kinase activity | Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. |
MYLK |
GO:0004689 | MF | phosphorylase kinase activity | Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. |
PHKA2, PHKA1 |
GO:0004691 | MF | cAMP-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP. |
PRKACA, PRKX, PRKAG1, AKAP13 |
GO:0004693 | MF | cyclin-dependent protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). |
CCNB2, CDK1, CDK4, CCNB1, MAK, CDK11B, CDK2, CCND3, CDK8, CDK7, CDK3, CDK6, CDK5, CDK16, CDK13, CDK10, CDK19, CDK12, CDK11A |
GO:0004694 | MF | eukaryotic translation initiation factor 2alpha kinase activity | Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. |
EIF2AK4 |
GO:0004697 | MF | protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. |
PRKCB, PRKCA, PRKCI, PRKCQ, PRKCD, PRKD1, PKN1, PKN2, PRKD2 |
GO:0004698 | MF | calcium-dependent protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium. |
PRKCB, CCL3, PRKCA |
GO:0004699 | MF | calcium-independent protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium. |
PRKCD |
GO:0004702 | MF | receptor signaling protein serine/threonine kinase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
MAP2K7, PAK3, MAP4K4, ACVR2A, MAP2K2, BMPR1A, ACVR1B, TGFBR1, TGFBR2, MAP3K8, NEK4, MAP2K6, TGFB2, MAP2K1, ACVR1, STK4, MAP2K5, PAK2, ACVR2B, BMPR2, AMHR2, NRK, MAP4K3, MINK1, NEK1, TAOK3, PAK7, TNIK, TAOK2, MAP4K5, STK24 |
GO:0004703 | MF | G-protein coupled receptor kinase activity | Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate. |
GRK5, ADRBK2, GRK6 |
GO:0004704 | MF | NF-kappaB-inducing kinase activity | Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK). |
IRAK1, PPP4C |
GO:0004705 | MF | JUN kinase activity | Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. |
MAPK8, MAPK9 |
GO:0004707 | MF | MAP kinase activity | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
MAPK13, MAPK3, MAPK1, MAPK7, MAPK14, NLK |
GO:0004708 | MF | MAP kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
MAP2K7, PAK3, MAP2K2, MAP2K6, MAP2K1, MAPK14 |
GO:0004709 | MF | MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
MAP3K13, MAP3K7, EGFR, RAF1, MAP3K8, MAP3K7CL, MLK4, MAP3K5, ZAK, MAP3K4 |
GO:0004711 | MF | ribosomal protein S6 kinase activity | Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. |
RPS6KA2 |
GO:0004712 | MF | protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
AURKA, PRKACA, AKT1, TTK, MAP2K2, CLK2, PRKAA2, MAP2K1, TNK2, ACVR2B, RPS6KA2, RPS6KA1, TESK1, DSTYK, DYRK2, AURKB, CLK4 |
GO:0004713 | MF | protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
MAP2K7, EREG, MUSK, JAK2, FGF18, ERLIN2, EGFR, ERBB2, INSR, FYN, HSP90AA1, LYN, IGF1R, MET, FGF2, PDGFRB, FGR, KIT, BCR, FGFR1, FGF7, FGFR2, ERBB3, JAK1, EPHB2, LTK, WEE1, FGF9, TTK, BTC, MAP2K2, CSK, STAT5A, ABL2, SYK, CLK2, STAT5B, JAK3, MAP2K6, IL5RA, NRG1, MAP2K1, TEK, PTK2, TYRO3, TNK2, MAP2K5, CUX1, ERBB4, TESK1, CDC37, DSTYK, TTN, DYRK2, SCYL1, NEK1, HBEGF, CLK4, FGFR1OP2, ZMYM2, BAZ1B |
GO:0004714 | MF | transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
MUSK, EGFR, ERBB2, NTRK1, KIT, PDGFRA, LTK, TIE1, FLT4, EPHB4, ROR1, TEK, TYRO3, DDR1, MERTK, ERBB4 |
GO:0004715 | MF | non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. |
RIPK2, JAK2, FYN, LYN, FGR, JAK1, WEE1, CSK, ABL2, SYK, JAK3, PTK2, PRKCD, TNK2, MELK, STYK1, SGK223, BAZ1B |
GO:0004716 | MF | receptor signaling protein tyrosine kinase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
EGFR, ERBB2, INSR, LYN, KIT, SYK, TYRO3, ERBB4 |
GO:0004719 | MF | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. |
PCMT1, PCMTD1 |
GO:0004720 | MF | protein-lysine 6-oxidase activity | Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide. |
LOX, LOXL2 |
GO:0004721 | MF | phosphoprotein phosphatase activity | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
PLPP3, CTDSPL, CDC25A, CDC25B, CDC25C, PPP1CC, PTEN, PPP1CA, PTPN11, DLG1, MTM1, DLGAP5, TIMM50, TNS2, SSH2, PPP1R3B, DUSP9, CPPED1, DUSP26, DUSP16, PHPT1, PPM1H, CDC14A, DUSP10 |
GO:0004722 | MF | protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
PP2D1, PPP6C, PPM1G, CDC14B, PPM1B, CTDNEP1, PPP1R3D, PPP2R1A, PPP1CC, PPM1F, PTEN, PPP4C, PPP1CA, PPP2CB, CYCS, PPP3CA, PPP2R5D, TAB1, CDKN3, TIMM50, PPM1J, PHLPP2, PPM1K, PPTC7, UBLCP1, PPM1E, DUSP23, PPA2, MTMR4, PDP1, PPM1H, CDC14A |
GO:0004725 | MF | protein tyrosine phosphatase activity | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
PTPDC1, EYA2, CDC14B, DUSP11, EYA4, PTPRC, PTPRF, PTPN2, PTPRG, PTPRM, CDC25A, CDC25B, CDC25C, PTPN9, DUSP3, TPTE, PTEN, DUSP2, PTPN11, PTPRJ, DUSP8, MTM1, MTMR1, MTMR2, PTPRK, CDKN3, DUSP5, PTPN21, PTPRO, DUSP6, DUSP7, TIMM50, SSH2, DUSP18, SSH3, UBASH3B, DUSP19, PTPMT1, PTP4A1, DUSP9, DUSP26, DUSP23, DUSP16, DUSP21, DUSP22, MTMR4, DUSP13, CDC14A, PTPN22, DUSP10 |
GO:0004726 | MF | non-membrane spanning protein tyrosine phosphatase activity | Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. |
PTPN2, DUSP1, PTPN4, PTPN9, PTPN11 |
GO:0004727 | MF | prenylated protein tyrosine phosphatase activity | Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. |
PTP4A2 |