| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:1990723 | CC | cytoplasmic periphery of the nuclear pore complex | Cytoplasm situated in close proximity to a nuclear pore complex. |
RANGAP1, RANBP2 |
GO:1990726 | CC | Lsm1-7-Pat1 complex | A conserved protein complex that plays an important role in coupling deadenylation and decapping in the 5'-to-3' mRNA decay pathway. An example is found in S. cerevisiae. |
LSM3, LSM7, LSM2, LSM5 |
GO:1990730 | CC | VCP-NSFL1C complex | A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97. |
VCP, NSFL1C |
GO:1990737 | BP | response to manganese-induced endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus. |
EIF2S1, ATF4 |
GO:1990745 | CC | EARP complex | A quatrefoil tethering complex required for endocytic recycling. |
VPS52 |
GO:1990752 | CC | microtubule end | Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. |
CLIP1, ACTR1B, KIF18B |
GO:1990761 | CC | growth cone lamellipodium | A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments. |
APBB1, APP |
GO:1990763 | MF | arrestin family protein binding | Interacting selectively and non-covalently with any member of the arrestin family, proteins involved in agonist-mediated desensitization of G-protein-coupled receptors. |
CREB1 |
GO:1990774 | BP | tumor necrosis factor secretion | The regulated release of tumor necrosis factor from a cell. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. |
HMGB1 |
GO:1990776 | BP | response to angiotensin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. |
CYBB, IQGAP1 |
GO:1990782 | MF | protein tyrosine kinase binding | Interacting selectively and non-covalently with protein tyrosine kinase. |
CD4, TRIM6, IL1RAP |
GO:1990785 | BP | response to water-immersion restraint stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile. |
FOXO3, FOXO4, MDM2 |
GO:1990791 | BP | dorsal root ganglion development | The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure. |
CTNNB1 |
GO:1990796 | CC | photoreceptor cell terminal bouton | A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light. |
STX3 |
GO:1990809 | BP | endoplasmic reticulum tubular network membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane. |
ARL6IP1 |
GO:1990812 | CC | growth cone filopodium | A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone. |
APBB1, APP, FMR1 |
GO:1990822 | BP | basic amino acid transmembrane transport | The directed movement of basic amino acids from one side of a membrane to the other. |
SLC7A2, SLC7A7 |
GO:1990825 | MF | sequence-specific mRNA binding | Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif. |
FMR1, LIN28A |
GO:1990828 | BP | hepatocyte dedifferentiation | The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. |
HNRNPD |
GO:1990841 | MF | promoter-specific chromatin binding | Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA. |
EGR1, DNMT1, RBL1, FOXO4, HSF1, TRIM28, EZH2, EHMT2, CHD7, PPARGC1A |
GO:1990843 | CC | subsarcolemmal mitochondrion | A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers. |
PPARGC1A |
GO:1990844 | CC | interfibrillar mitochondrion | A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers. |
PPARGC1A |
GO:1990845 | BP | adaptive thermogenesis | The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature. |
PPARGC1A |
GO:1990851 | CC | Wnt-Frizzled-LRP5/6 complex | A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6. |
LRP5, LRP6, FZD8 |
GO:1990879 | CC | CST complex | A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection. |
OBFC1 |
GO:1990889 | MF | H4K20me3 modified histone binding | Interacting selectively and non-covalently with a histone H4 in which the lysine residue at position 20 has been modified by trimethylation. |
PWP1 |
GO:1990904 | CC | ribonucleoprotein complex | A macromolecular complex containing both protein and RNA molecules. |
ZFP36, FMR1, ELAVL1 |
GO:1990907 | CC | beta-catenin-TCF complex | A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. |
CTNNB1 |
GO:1990909 | CC | Wnt signalosome | A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. |
LRP5, LRP6, WNT2, APC, CTNNB1, GSK3B, WNT3 |
GO:1990910 | BP | response to hypobaric hypoxia | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level). |
HSF1 |
GO:1990911 | BP | response to psychosocial stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism. |
HSF1 |
GO:1990913 | CC | sperm head plasma membrane | The plasma membrane that is part of the head section of a sperm cell. |
HSP90AB1 |
GO:1990917 | CC | ooplasm | The cytoplasm of an ovum. |
HSP90AB1 |
GO:1990927 | BP | calcium ion regulated lysosome exocytosis | The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. |
SYT11 |
GO:1990928 | BP | response to amino acid starvation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. |
EIF4EBP1 |
GO:1990931 | MF | RNA N6-methyladenosine dioxygenase activity | Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde. |
FTO |
GO:1990932 | MF | 5.8S rRNA binding | Interacting selectively and non-covalently with 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA. |
RPS13, RPL19 |
GO:1990938 | BP | peptidyl-aspartic acid autophosphorylation | The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein. |
ATP13A2 |
GO:1990966 | BP | ATP generation from poly-ADP-D-ribose | The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. |
PARP1, NUDT5 |
GO:1990967 | BP | multi-organism toxin transport | The directed movement of a toxin into, out of or within a cell, or between cells where two or more organisms of the same or different species are involved. |
RAB29, RAB40B |
GO:1990968 | BP | modulation by host of RNA binding by virus | A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA. |
NUCKS1 |
GO:1990969 | BP | modulation by host of viral RNA-binding transcription factor activity | A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor. |
NUCKS1 |
GO:2000001 | BP | regulation of DNA damage checkpoint | Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. |
CUL4A, CRY1, RNASEH2B, RFWD3, FEM1B |
GO:2000003 | BP | positive regulation of DNA damage checkpoint | Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint. |
CCAR2 |
GO:2000005 | BP | negative regulation of metanephric S-shaped body morphogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis. |
BMP4 |
GO:2000007 | BP | negative regulation of metanephric comma-shaped body morphogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis. |
BMP4 |
GO:2000008 | BP | regulation of protein localization to cell surface | Any process that modulates the frequency, rate or extent of protein localization to the cell surface. |
TOR1A, CTNNB1, RAB11B, HFE, GBF1 |
GO:2000009 | BP | negative regulation of protein localization to cell surface | Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface. |
TAX1BP3, LEPROT, ACTN2, GPM6B, COMMD1, SNX33, NEDD4L |
GO:2000010 | BP | positive regulation of protein localization to cell surface | Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. |
TNF, SYNJ2BP, NRG1, STX4, STX3, ERBB4, SNX33, RANGRF |
GO:2000016 | BP | negative regulation of determination of dorsal identity | Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity. |
DDIT3 |
GO:2000017 | BP | positive regulation of determination of dorsal identity | Any process that activates or increases the frequency, rate or extent of determination of dorsal identity. |
CTNNB1, ACVR1 |
GO:2000020 | BP | positive regulation of male gonad development | Any process that activates or increases the frequency, rate or extent of male gonad development. |
WT1, SOX9, SEMA3A, ZFPM2, CITED2 |
GO:2000021 | BP | regulation of ion homeostasis | Any process that modulates the frequency, rate or extent of ion homeostasis. |
WNK3, WNK1 |
GO:2000027 | BP | regulation of organ morphogenesis | Any process that modulates the frequency, rate or extent of animal organ morphogenesis. |
TBX1 |
GO:2000035 | BP | regulation of stem cell division | Any process that modulates the frequency, rate or extent of stem cell division. |
SOX17, NAP1L2 |
GO:2000036 | BP | regulation of stem cell population maintenance | Any process that modulates the frequency, rate or extent of stem cell population maintenance. |
CNOT1, CNOT3, TAL1, HMGA2, ELAVL1 |
GO:2000041 | BP | negative regulation of planar cell polarity pathway involved in axis elongation | Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation. |
SFRP1 |
GO:2000042 | BP | negative regulation of double-strand break repair via homologous recombination | Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination. |
POLQ, FBXO18, PARPBP |
GO:2000043 | BP | regulation of cardiac cell fate specification | Any process that modulates the frequency, rate or extent of cardiac cell fate specification. |
SOX17 |
GO:2000045 | BP | regulation of G1/S transition of mitotic cell cycle | Any cell cycle regulatory process that controls the commitment of a cell from G1 to S phase of the mitotic cell cycle. |
BID, PSME3, E2F1, ID2, KIF14, PID1, PDPN |
GO:2000048 | BP | negative regulation of cell-cell adhesion mediated by cadherin | Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin. |
PLG, EPCAM, RGCC |
GO:2000049 | BP | positive regulation of cell-cell adhesion mediated by cadherin | Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin. |
FLOT1, WNT5A |
GO:2000050 | BP | regulation of non-canonical Wnt signaling pathway | Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. |
TIAM1 |
GO:2000052 | BP | positive regulation of non-canonical Wnt signaling pathway | Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. |
WNT5A, CSNK1D, CSNK1E, SFRP1, RSPO3 |
GO:2000054 | BP | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification | Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. |
SFRP1, SOST |
GO:2000055 | BP | positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification | Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. |
LRP6 |
GO:2000057 | BP | negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis. |
SFRP5 |
GO:2000059 | BP | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | Any process that stops, prevents, or reduces the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. |
PSEN1, HFE, PDCL3, TRIM39, SUFU |
GO:2000060 | BP | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | Any process that activates or increases the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. |
AXIN1, CLU, PTEN, PTK2, FBXO22 |
GO:2000065 | BP | negative regulation of cortisol biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process. |
BMP2, DKK3 |
GO:2000074 | BP | regulation of type B pancreatic cell development | Any process that modulates the frequency, rate or extent of pancreatic B cell development. |
ARNTL, RHEB |
GO:2000077 | BP | negative regulation of type B pancreatic cell development | Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. |
GSK3B |
GO:2000078 | BP | positive regulation of type B pancreatic cell development | Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. |
BAD |
GO:2000080 | BP | negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation | Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. |
SFRP1 |
GO:2000095 | BP | regulation of Wnt signaling pathway, planar cell polarity pathway | Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. |
NPHP3, MKS1, DACT1 |
GO:2000096 | BP | positive regulation of Wnt signaling pathway, planar cell polarity pathway | Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. |
DAB2, RSPO3 |
GO:2000097 | BP | regulation of smooth muscle cell-matrix adhesion | Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion. |
PLAU |
GO:2000098 | BP | negative regulation of smooth muscle cell-matrix adhesion | Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion. |
APOD, SERPINE1 |
GO:2000105 | BP | positive regulation of DNA-dependent DNA replication | Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication. |
BMP4, BMP6 |
GO:2000107 | BP | negative regulation of leukocyte apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. |
HCLS1, CXCL12, MERTK |
GO:2000108 | BP | positive regulation of leukocyte apoptotic process | Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. |
NR4A3 |
GO:2000109 | BP | regulation of macrophage apoptotic process | Any process that modulates the frequency, rate or extent of macrophage apoptotic process. |
TCP1 |
GO:2000110 | BP | negative regulation of macrophage apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. |
CCL5, VIMP |
GO:2000111 | BP | positive regulation of macrophage apoptotic process | Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process. |
MEF2C |
GO:2000114 | BP | regulation of establishment of cell polarity | Any process that modulates the frequency, rate or extent of establishment of cell polarity. |
KRIT1, ROCK2, CDH5, RACK1, KANK1, RICTOR, RUFY3, KIF20B |
GO:2000116 | BP | regulation of cysteine-type endopeptidase activity | Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity. |
PSMB9, BIRC3 |
GO:2000117 | BP | negative regulation of cysteine-type endopeptidase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. |
CST3, CST2, MT3, IFI16 |
GO:2000119 | BP | negative regulation of sodium-dependent phosphate transport | Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport. |
SFRP4 |
GO:2000121 | BP | regulation of removal of superoxide radicals | Any process that modulates the frequency, rate or extent of removal of superoxide radicals. |
DHFR, CD36 |
GO:2000124 | BP | regulation of endocannabinoid signaling pathway | Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway. |
MGLL, ABHD6 |
GO:2000134 | BP | negative regulation of G1/S transition of mitotic cell cycle | Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle. |
CTDSP2, CTDSPL, RB1, BCL2, CDKN1A, CDKN2B, SMARCA4, PTEN, PKD2, FHL1, EZH2, KANK2, JADE1, ZNF655, CTDSP1, BRD7, DACT1 |
GO:2000137 | BP | negative regulation of cell proliferation involved in heart morphogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. |
BMP4 |
GO:2000138 | BP | positive regulation of cell proliferation involved in heart morphogenesis | Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. |
BMP10, SOX9 |
GO:2000142 | BP | regulation of DNA-templated transcription, initiation | Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. |
RRN3 |
GO:2000143 | BP | negative regulation of DNA-templated transcription, initiation | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation. |
THRA |
GO:2000144 | BP | positive regulation of DNA-templated transcription, initiation | Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. |
MITF, JUN, FOSL1, CTNNB1, TWIST1, SETX, BCLAF1 |
GO:2000145 | BP | regulation of cell motility | Any process that modulates the frequency, rate or extent of cell motility. |
EREG, DAPK3, ROCK2, EGFR, RAF1, ERBB2, ERBB3, BTC, ABL2, CD81, RHOA, CDK6, NRG1, ERBB4, PKN1, PKN2, ARHGAP18, HBEGF, SSX2IP |
GO:2000146 | BP | negative regulation of cell motility | Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. |
SPINT2, FBLN1, CTNNA1, SPOCK3 |
GO:2000147 | BP | positive regulation of cell motility | Any process that activates or increases the frequency, rate or extent of cell motility. |
CSF1R, EPCAM, AKT2, TWIST1, SPOCK2, PHPT1 |
GO:2000156 | BP | regulation of retrograde vesicle-mediated transport, Golgi to ER | Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER. |
BET1L |