GO:1990029

BP

vasomotion

The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm.

GJA5

GO:1990035

BP

calcium ion import into cell

The directed movement of calcium ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.

TRPV1, TRPV6

GO:1990036

BP

calcium ion import into sarcoplasmic reticulum

The directed movement of calcium ions into a sarcoplasmic reticulum.

ATP2A2

GO:1990037

CC

Lewy body core

The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments.

ATF4

GO:1990047

CC

spindle matrix

A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis.

ZNF207

GO:1990050

MF

phosphatidic acid transporter activity

Enables the directed movement of phosphatidic acid into, out of or within a cell, or between cells. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3.

TRIAP1, PRELID1

GO:1990051

BP

activation of protein kinase C activity

Any process that initiates the activity of the inactive enzyme protein kinase C.

LEP

GO:1990071

CC

TRAPPII protein complex

A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the pre-autophagosomal structure. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself.

TRAPPC10

GO:1990075

CC

periciliary membrane compartment

A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis.

RP2, KIFAP3

GO:1990077

CC

primosome complex

Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart.

PRIM1, PRIM2

GO:1990086

BP

lens fiber cell apoptotic process

Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.

TGFBR2, E2F1, E2F2

GO:1990090

BP

cellular response to nerve growth factor stimulus

A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.

ARPC3, FOXO3, NTRK1, APP, CREB1, AKT1, ID1, CSNK1D, CSNK1E, RAP1A, E2F1, RAPGEF1, ACAP2, MAGI2, TRPV1, CDC5L, CIB1, KIDINS220

GO:1990111

CC

spermatoproteasome complex

A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity.

PSMB8, PSMB9, PSMB10, PSME4

GO:1990117

BP

B cell receptor apoptotic signaling pathway

An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell.

BAX

GO:1990124

CC

messenger ribonucleoprotein complex

A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.

HNRNPA3, CPEB4, CPEB2, CPEB3

GO:1990126

BP

retrograde transport, endosome to plasma membrane

The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.

WASH1, VPS26A, RAB11B, ANKRD27, VPS35, VPS29, ANKRD50

GO:1990130

CC

Iml1 complex

A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.

NPRL3

GO:1990131

CC

Gtr1-Gtr2 GTPase complex

A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins.

RRAGC, RRAGD

GO:1990138

BP

neuron projection extension

Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

AURKA, IQGAP1, PLXNA3, TIAM1, ALCAM, POSTN, NDEL1, FLRT3, FLRT1, EIF2AK4, IMPACT, PLXNA1

GO:1990144

BP

intrinsic apoptotic signaling pathway in response to hypoxia

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered.

BNIP3

GO:1990145

BP

maintenance of translational fidelity

Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template.

CDKAL1

GO:1990166

BP

protein localization to site of double-strand break

Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred.

SLF2, SLF1

GO:1990168

BP

protein K33-linked deubiquitination

A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein.

ZRANB1

GO:1990174

MF

phosphodiesterase decapping endonuclease activity

Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA.

EDC3

GO:1990180

BP

mitochondrial tRNA 3'-end processing

The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion.

TRNT1

GO:1990182

BP

exosomal secretion

The process whereby a membrane-bounded vesicle are released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.

RAB27A, RAB11A

GO:1990188

MF

euchromatin binding

Interacting selectively and non-covalently with euchromatin, a dispersed and relatively uncompacted form of chromatin.

CTNNB1, ASH2L

GO:1990226

MF

histone methyltransferase binding

Interacting selectively and non-covalently with a histone methyltransferase enzyme.

NOP56, CBX1, CBX3

GO:1990234

CC

transferase complex

A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).

UBE2I, PDSS1, PDSS2

GO:1990239

MF

steroid hormone binding

Interacting selectively and non-covalently with a steroid hormone.

NR3C1, ATP1A2, GPER1

GO:1990246

CC

uniplex complex

A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.

MICU2

GO:1990247

MF

N6-methyladenosine-containing RNA binding

Interacting selectively and non-covalently with an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs.

HNRNPC, HNRNPA2B1, YTHDF3, YTHDC1, YTHDF1, YTHDC2, YTHDF2

GO:1990253

BP

cellular response to leucine starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine.

GCN1, EIF2AK4, IMPACT

GO:1990254

MF

keratin filament binding

Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.

VIM, FAM83H

GO:1990256

BP

signal clustering

Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response.

SEMA5A

GO:1990261

BP

pre-mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA).

ZPR1

GO:1990262

BP

anti-Mullerian hormone signaling pathway

A series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

AMHR2

GO:1990268

BP

response to gold nanoparticle

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus.

MPO

GO:1990272

MF

anti-Mullerian hormone receptor activity

Combining with anti-Mullerian hormone to initiate a change in cell activity.

AMHR2

GO:1990298

CC

bub1-bub3 complex

Protein complex that associates with the kinetochores.

BUB3

GO:1990314

BP

cellular response to insulin-like growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.

TGFB1, CREB1, CCNA2, FBN1

GO:1990316

CC

ATG1/ULK1 kinase complex

A protein complex consisting of ATG1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.

ATG13, ULK1, SESN2, RB1CC1, TBC1D5

GO:1990332

CC

Ire1 complex

A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.

ERN1

GO:1990349

BP

gap junction-mediated intercellular transport

The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells.

MIP

GO:1990356

CC

sumoylated E2 ligase complex

A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase.

UBE2I

GO:1990357

CC

terminal web

An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.

KRT19, PLS1, HFE

GO:1990379

BP

lipid transport across blood brain barrier

The directed movement of lipid molecules passing through the blood-brain barrier.

MFSD2A

GO:1990380

MF

Lys48-specific deubiquitinase activity

Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein.

USP27X, ATXN3, OTUD7B

GO:1990381

MF

ubiquitin-specific protease binding

Interacting selectively and non-covalently with a ubiquitin-specific protease.

PARK2, RAD23A, VCP, SART3, SYVN1, VIMP, AMFR

GO:1990391

CC

DNA repair complex

A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

KDM1A

GO:1990393

CC

3M complex

A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity.

OBSL1, CUL7, CCDC8

GO:1990401

BP

embryonic lung development

The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure.

PDGFA

GO:1990402

BP

embryonic liver development

The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure.

TGFB1

GO:1990403

BP

embryonic brain development

The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure.

CTNNB1, TRA2B, MED12, MKS1, CC2D2A

GO:1990414

BP

replication-born double-strand break repair via sister chromatid exchange

The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.

RAD51

GO:1990416

BP

cellular response to brain-derived neurotrophic factor stimulus

A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.

EEF2

GO:1990418

BP

response to insulin-like growth factor stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.

XBP1, AKT1

GO:1990423

CC

RZZ complex

A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints.

KNTC1, ZWILCH

GO:1990426

BP

mitotic recombination-dependent replication fork processing

Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart.

BRCA2, RAD51

GO:1990428

BP

miRNA transport

The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.

HNRNPA2B1

GO:1990429

CC

peroxisomal importomer complex

A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners.

PEX12

GO:1990430

MF

extracellular matrix protein binding

Interacting selectively and non-covalently with a protein that is part of an extracellular matrix.

ITGAV, ITGB8

GO:1990440

BP

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress.

TP53, HSPA5, CEBPB, ATF3, ATF4, ATF6, DDIT3, CREB3L1

GO:1990441

BP

negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress.

PPP1R15A, JUN

GO:1990444

MF

F-box domain binding

Interacting selectively and non-covalently with an F-box domain of a protein.

PARK2

GO:1990446

MF

U1 snRNP binding

Interacting selectively and non-covalently with any part of a U1 small nuclear ribonucleoprotein particle.

SNRPA, SNRPC, SNRPD1, SNRPD3

GO:1990452

CC

Parkin-FBXW7-Cul1 ubiquitin ligase complex

A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein.

PARK2

GO:1990454

CC

L-type voltage-gated calcium channel complex

A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.

CACNB3, CACNA2D1, CACNA1C

GO:1990459

MF

transferrin receptor binding

Interacting selectively and non-covalently with the transferrin receptor.

SNX4, TF, CD81, SNX1, HFE

GO:1990460

MF

leptin receptor binding

Interacting selectively and non-covalently with the leptin receptor.

SNX4, SNX1

GO:1990481

BP

mRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.

DKC1, TRUB1

GO:1990502

BP

dense core granule maturation

Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.

SNX19

GO:1990523

BP

bone regeneration

The regrowth of bone following its loss or destruction.

POSTN

GO:1990539

BP

fructose import across plasma membrane

The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol.

SLC2A5

GO:1990565

CC

HSP90-CDC37 chaperone complex

A protein complex involved in stress-induced mitophagy (mitochondrial degradation). In mammals it consists of heat shock protein HSP90 and its co-chaperone CDC37. Experimental evidence suggests that the complex enables the autophosphorylation of ULK1. Phosphorylated ULK1 in turn phosphorylates ATG13 which is an essential step in mitophagy. HSP90-CDC37 binding prevents rapid ubiquitin-dependent proteosomal degradation of its targets.

CDC37

GO:1990569

BP

UDP-N-acetylglucosamine transmembrane transport

The directed movement of UDP-N-acetylglucosamine across a membrane.

SLC35A3

GO:1990573

BP

potassium ion import across plasma membrane

The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.

ATP1B1, ATP1A2

GO:1990578

CC

perinuclear endoplasmic reticulum membrane

The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus.

PIK3R1

GO:1990579

BP

peptidyl-serine trans-autophosphorylation

The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer.

ERN1

GO:1990583

MF

phospholipase D activator activity

Increases the activity of the enzyme phospholipase D.

ARF1

GO:1990589

CC

ATF4-CREB1 transcription factor complex

Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.

CREB1, ATF4

GO:1990590

CC

ATF1-ATF4 transcription factor complex

Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway.

ATF1, ATF4

GO:1990592

BP

protein K69-linked ufmylation

A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.

UFM1, UBA5

GO:1990597

CC

AIP1-IRE1 complex

A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).

ERN1

GO:1990603

BP

dark adaptation

The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light.

PAPD4

GO:1990604

CC

IRE1-TRAF2-ASK1 complex

A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K).

ERN1, MAP3K5

GO:1990614

BP

mitochondrial magnesium ion transmembrane transport

A process in which a magnesium ion is transported from one side of a mitochondrial membrane to the other by means of some agent such as a transporter or pore.

MRS2

GO:1990617

CC

CHOP-ATF4 complex

A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits.

ATF4, DDIT3

GO:1990622

CC

CHOP-ATF3 complex

A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits.

ATF3, DDIT3

GO:1990630

CC

IRE1-RACK1-PP2A complex

A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A.

ERN1, RACK1

GO:1990637

BP

response to prolactin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation.

GNRH1

GO:1990641

BP

response to iron ion starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.

HAMP, HFE

GO:1990646

BP

cellular response to prolactin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus.

IL6, CDC5L

GO:1990666

CC

PCSK9-LDLR complex

A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.

LDLR, PCSK9

GO:1990667

CC

PCSK9-AnxA2 complex

A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and Annexin A2 (AnxA2).

ANXA2, PCSK9

GO:1990682

CC

CSF1-CSF1R complex

A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand.

CSF1R

GO:1990698

MF

palmitoleoyltransferase activity

Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule.

CPT1A

GO:1990707

CC

nuclear subtelomeric heterochromatin

Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus.

ATRX

GO:1990712

CC

HFE-transferrin receptor complex

A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.

TFRC, TF, BMPR1A, B2M, HFE, TFR2

GO:1990715

MF

mRNA CDS binding

Interacting selectively and non-covalently with the coding sequence (CDS) of an mRNA molecule.

UNK