GO:0097300

BP

programmed necrotic cell death

A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

CASP1, MAP3K5

GO:0097310

BP

cap2 mRNA methylation

Methylation of the ribose of the first and second nucleotides of a 5'-capped mRNA.

CMTR2

GO:0097320

BP

membrane tubulation

A modification in a plasma membrane resulting in formation of a tubular invagination.

FNBP1L, SNX33, PACSIN1, BIN2, SNX9

GO:0097322

MF

7SK snRNA binding

Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA).

CCNT1, CCNT2, HEXIM1

GO:0097324

BP

melanocyte migration

The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.

ZEB2, KIT

GO:0097325

BP

melanocyte proliferation

The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.

WNT5A

GO:0097326

BP

melanocyte adhesion

The attachment of a melanocyte to another cell via adhesion molecules.

KIT

GO:0097327

BP

response to antineoplastic agent

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms.

RAP1A

GO:0097332

BP

response to antipsychotic drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.

PRKAR2B

GO:0097338

BP

response to clozapine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus.

PRKAR2B

GO:0097342

CC

ripoptosome

A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.

CFLAR, FADD, RIPK1, CASP8

GO:0097343

BP

ripoptosome assembly

The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.

RIPK1

GO:0097345

BP

mitochondrial outer membrane permeabilization

The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.

EYA2, BNIP3L, BID, BNIP3

GO:0097350

BP

neutrophil clearance

The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms.

ANXA1, HMGB1

GO:0097352

BP

autophagosome maturation

The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome.

SNAPIN, SNAP29, VCP, CLN3, TECPR1, EPG5

GO:0097359

BP

UDP-glucosylation

The covalent attachment of a UDP-glucose residue to a substrate molecule.

UGGT1

GO:0097361

CC

CIA complex

The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity.

CIAO1, FAM96B

GO:0097362

CC

MCM8-MCM9 complex

A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links.

MCM8

GO:0097363

MF

protein O-GlcNAc transferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine.

OGT, POMGNT2

GO:0097368

BP

establishment of Sertoli cell barrier

Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions.

ICAM1, ARID4B

GO:0097371

MF

MDM2/MDM4 family protein binding

Interacting selectively and non-covalently with any isoform of the MDM2/MDM4 protein family, comprising negative regulators of p53.

PSME3, PPARA, RFWD3

GO:0097374

BP

sensory neuron axon guidance

The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.

NRP1

GO:0097381

CC

photoreceptor disc membrane

Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment.

GUCA1C, GNB1, GUCY2D, GUCA1B

GO:0097383

MF

dIDP diphosphatase activity

Catalysis of the reaction: dIDP + H2O = dIMP + phosphate.

NUDT16

GO:0097386

CC

glial cell projection

A prolongation or process extending from a glial cell.

FMR1, SIRT2

GO:0097403

BP

cellular response to raffinose

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus.

ZFP36L1

GO:0097411

BP

hypoxia-inducible factor-1alpha signaling pathway

A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.

CYBB, PDK1, HIF1A

GO:0097413

CC

Lewy body

Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein.

PARK2, GPX1, PINK1

GO:0097418

CC

neurofibrillary tangle

Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.

MAPT, CLU, NEFH, PICALM

GO:0097421

BP

liver regeneration

The regrowth of lost or destroyed liver.

EGFR, TGFB1, VTN, TYMS, HMOX1, PCNA, CEBPB, IL10, UCP2, RPS16, RAP1A, RPL32, HAMP, RPL19, SRSF1, SRSF5, RGN, EZH2, HFE, SULF2, CPB2

GO:0097422

CC

tubular endosome

A network of fine tubules in the vicinity of the Golgi complex and around the centriole.

VPS26A, ANKRD27, VPS35, SNX6, SNX5

GO:0097428

BP

protein maturation by iron-sulfur cluster transfer

The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.

ISCA1

GO:0097431

CC

mitotic spindle pole

Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

EML1, GPSM2, ASPM, NIN, KIF20B, FAM83D

GO:0097433

CC

dense body

An electron dense body which may contain granules.

ACTB, ACTG1, SYBU

GO:0097435

BP

fibril organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, insoluble fibrous aggregates consisting of polysaccharides and/or proteins.

HSP90AB1

GO:0097440

CC

apical dendrite

A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.

MYO1D, CLU, FLNA, NSMF, CPEB3, PPARGC1A

GO:0097443

CC

sorting endosome

A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles.

NRP1

GO:0097447

CC

dendritic tree

The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.

ELOVL5

GO:0097449

CC

astrocyte projection

A prolongation or process extending from the soma of an astrocyte and wrapping around neurons.

APP, EZR, PINK1

GO:0097450

CC

astrocyte end-foot

Terminal process of astrocyte abutting non-neuronal surfaces in the brain.

MT3

GO:0097451

CC

glial limiting end-foot

Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans.

EIF2S1, ADGRG1

GO:0097452

CC

GAIT complex

A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.

SYNCRIP, GAPDH, EPRS, RPL13A

GO:0097453

CC

mesaxon

Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide.

MAG

GO:0097454

CC

Schwann cell microvillus

Small finger-like extension of a Schwann cell that contacts the nodal membrane.

AKR1B1, EZR

GO:0097459

BP

iron ion import into cell

The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.

PICALM, HFE

GO:0097460

BP

ferrous iron import into cell

The directed movement of ferrous iron (Fe(II) or Fe2+) ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.

TF, TFR2

GO:0097461

BP

ferric iron import into cell

The directed movement of ferric iron (Fe(III) or Fe3+) ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.

STEAP4

GO:0097466

BP

glycoprotein ERAD pathway

An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.

EDEM1

GO:0097470

CC

ribbon synapse

Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm.

ATP2A2, CTBP2, STX3

GO:0097477

BP

lateral motor column neuron migration

The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme.

DAB1

GO:0097484

BP

dendrite extension

Long distance growth of a single dendrite involved in cellular development.

STK11, SLC9A6, LLPH

GO:0097485

BP

neuron projection guidance

The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.

DPYSL4

GO:0097486

CC

multivesicular body lumen

The volume enclosed by the outermost membrane of a multivesicular body.

CTSH, SFTPC

GO:0097489

CC

multivesicular body, internal vesicle lumen

The volume enclosed by the membrane of the multivesicular body internal vesicle.

EGFR

GO:0097490

BP

sympathetic neuron projection extension

Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

NRP1, NRP2, SEMA3A

GO:0097491

BP

sympathetic neuron projection guidance

The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.

NRP1, NRP2, SEMA3A

GO:0097493

MF

structural molecule activity conferring elasticity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling.

AHNAK, TTN

GO:0097494

BP

regulation of vesicle size

Any process that modulates the size of a vesicle.

RAB3B, RAB22A

GO:0097497

BP

blood vessel endothelial cell delamination

The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet.

TRPV4

GO:0097498

BP

endothelial tube lumen extension

Any endothelial tube morphogenesis process by which the tube is increased in length.

RHOA, STARD13

GO:0097500

BP

receptor localization to nonmotile primary cilium

A process in which a receptor is transported to, or maintained in, a location within a nonmotile primary cilium.

BBIP1, TULP3

GO:0097502

BP

mannosylation

The covalent attachment of a mannose residue to a substrate molecule.

ALG8, ALG9

GO:0097503

BP

sialylation

The covalent attachment of sialic acid to a substrate molecule.

ST6GAL1, ST8SIA6, ST3GAL1, ST3GAL3, ST3GAL4, ST3GAL2, ST8SIA4, ST6GAL2, ST6GALNAC5, ST6GALNAC4, ST6GALNAC2, ST3GAL6

GO:0097504

CC

Gemini of coiled bodies

Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA).

ZPR1, GEMIN4, NPAT, GEMIN5, GEMIN6, GEMIN8, DDX20

GO:0097505

CC

Rad6-Rad18 complex

A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity.

RAD18

GO:0097510

BP

base-excision repair, AP site formation via deaminated base removal

A base-excision repair, AP site formation process occurring via excision of a deaminated base.

UNG

GO:0097512

CC

cardiac myofibril

A cardiac myofibril is a myofibril specific to cardiac muscle cells.

CRYAB

GO:0097513

CC

myosin II filament

A bipolar filament composed of myosin II molecules.

MYH9

GO:0097524

CC

sperm plasma membrane

A plasma membrane that is part of a sperm cell.

HSP90AA1

GO:0097526

CC

spliceosomal tri-snRNP complex

A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins.

SNRPD1, SNRPD3, LSM7, LSM4

GO:0097527

BP

necroptotic signaling pathway

A series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered.

TLR3, TNF, FAS, FADD, RIPK1

GO:0097531

BP

mast cell migration

The movement of a mast cell within or between different tissues and organs of the body.

MITF, STAT5B

GO:0097539

CC

ciliary transition fiber

A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium).

CENPF, ODF2, NIN, FBF1, CEP89, CEP83

GO:0097542

CC

ciliary tip

Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction.

GLI2, GLI3, MAK, DYNLL1, DYNC2LI1, IFT81, KIFAP3, CLUAP1, WDR34, IFT43, IFT74, IFT27, IFT122, CYLD, IFT46, WDR35, SUFU, KIF3A, HSPB11

GO:0097543

CC

ciliary inversin compartment

Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium.

NPHP3, NEK8

GO:0097545

CC

axonemal outer doublet

Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium.

CCDC42B

GO:0097546

CC

ciliary base

Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.

TULP3, GLI2, GLI3, PRKAR1A, PRKAR2A, PRKACA, PRKAR2B, ARMC4, NPHP3, NEK8, C8orf37, IFT122, SUFU

GO:0097553

BP

calcium ion transmembrane import into cytosol

A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore.

ATP2B4

GO:0097573

MF

glutathione oxidoreductase activity

Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione.

GLRX

GO:0097581

BP

lamellipodium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.

CTTN

GO:0097602

MF

cullin family protein binding

Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3).

PARK2, RBX1, SKP1, DCUN1D4, DCUN1D1

GO:0097603

MF

temperature-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism).

TRPV1

GO:0097623

BP

potassium ion export across plasma membrane

The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.

KCNH2

GO:0097626

MF

low-affinity L-arginine transmembrane transporter activity

Catalysis of the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.

SLC7A2

GO:0097627

MF

high-affinity L-ornithine transmembrane transporter activity

Catalysis of the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.

SLC7A2

GO:0097629

CC

extrinsic component of omegasome membrane

The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

ULK1, ZFYVE1

GO:0097632

CC

extrinsic component of pre-autophagosomal structure membrane

The component of the pre-autophagosomal structure membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

ULK1

GO:0097635

CC

extrinsic component of autophagosome membrane

The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

ULK1

GO:0097638

BP

L-arginine import across plasma membrane

The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol.

SLC7A2

GO:0097639

BP

L-lysine import across plasma membrane

The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol.

SLC7A2

GO:0097640

BP

L-ornithine import across plasma membrane

The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol.

SLC7A2

GO:0097649

CC

A axonemal microtubule

A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule.

C6orf165

GO:0097655

MF

serpin family protein binding

Interacting selectively and non-covalently with any member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors.

CTSL

GO:0097676

BP

histone H3-K36 dimethylation

The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone.

ASH1L

GO:0097677

MF

STAT family protein binding

Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.

HSF1

GO:0097681

BP

double-strand break repair via alternative nonhomologous end joining

An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.

POLQ, PRKDC

GO:0097689

MF

iron channel activity

Enables the facilitated diffusion of an iron ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

SLC40A1

GO:0097708

CC

intracellular vesicle

Any vesicle that is part of the intracellular region.

RAB29

GO:0098505

MF

G-rich strand telomeric DNA binding

Interacting selectively and non-covalently with G-rich, single-stranded, telomere-associated DNA.

HNRNPA1, TERF1, NABP2, POT1

GO:0098507

BP

polynucleotide 5' dephosphorylation

The process of removing one or more phosphate groups from the 5' end of a polynucleotide.

DUSP11