| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0097035 | BP | regulation of membrane lipid distribution | Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. |
TRIAP1, PRELID1 |
GO:0097038 | CC | perinuclear endoplasmic reticulum | The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. |
ADAM10, TRIM13, BCAP31, OSBPL6 |
GO:0097039 | BP | protein linear polyubiquitination | A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein. |
RNF216 |
GO:0097045 | BP | phosphatidylserine exposure on blood platelet | A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system. |
ANO6 |
GO:0097049 | BP | motor neuron apoptotic process | Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. |
FAS, FADD |
GO:0097050 | BP | type B pancreatic cell apoptotic process | Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. |
RYR2, CAPN10 |
GO:0097051 | BP | establishment of protein localization to endoplasmic reticulum membrane | The directed movement of a protein to a specific location in the endoplasmic reticulum membrane. |
RAB3GAP1, RAB3GAP2 |
GO:0097052 | BP | L-kynurenine metabolic process | The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). |
GOT2 |
GO:0097053 | BP | L-kynurenine catabolic process | The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). |
KYNU |
GO:0097055 | BP | agmatine biosynthetic process | The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. |
AGMAT |
GO:0097056 | BP | selenocysteinyl-tRNA(Sec) biosynthetic process | The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine. |
SARS, SEPSECS |
GO:0097057 | CC | TRAF2-GSTP1 complex | A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses. |
GSTP1 |
GO:0097058 | CC | CRLF-CLCF1 complex | A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex. |
CLCF1 |
GO:0097059 | CC | CNTFR-CLCF1 complex | A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space. |
CLCF1 |
GO:0097060 | CC | synaptic membrane | A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. |
SYNJ1, SRPX2, CRYAB, ITGB1, CPE, ITGA3, MTMR2, NIPSNAP1, RIMS4, FLRT3 |
GO:0097061 | BP | dendritic spine organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. |
ARF1 |
GO:0097062 | BP | dendritic spine maintenance | The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. |
ITPKA, ITGA3, MTMR2, CTTN |
GO:0097066 | BP | response to thyroid hormone | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. |
ANXA2, AKR1B1 |
GO:0097067 | BP | cellular response to thyroid hormone stimulus | A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. |
CTSL, CTSB, CTSH, KIT, CTSS, LMO2, RDX, KLF9, PPARGC1A |
GO:0097069 | BP | cellular response to thyroxine stimulus | A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. |
GCLC, GCLM |
GO:0097070 | BP | ductus arteriosus closure | The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs. |
HPGD |
GO:0097084 | BP | vascular smooth muscle cell development | The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. |
ADM, HES1, SGCB |
GO:0097089 | BP | methyl-branched fatty acid metabolic process | The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain. |
SLC27A2 |
GO:0097091 | BP | synaptic vesicle clustering | The process that results in grouping synaptic vesicles, prior to release, at a specialized patch of the presynaptic membrane referred to as the active zone. |
NLGN1 |
GO:0097094 | BP | craniofacial suture morphogenesis | The process in which any suture between cranial and/or facial bones is generated and organized. |
FOXN3, MMP14, MMP16, RAB23 |
GO:0097100 | MF | supercoiled DNA binding | Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. |
PSIP1, HMGB1, HMGB2 |
GO:0097102 | BP | endothelial tip cell fate specification | The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels. |
NRP1 |
GO:0097104 | BP | postsynaptic membrane assembly | The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). |
NLGN1, NRXN1 |
GO:0097105 | BP | presynaptic membrane assembly | The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. |
PTPRD, PTEN, NLGN4X, NLGN1 |
GO:0097107 | BP | postsynaptic density assembly | The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. |
PTEN |
GO:0097108 | MF | hedgehog family protein binding | Interacting selectively and non-covalently with a member of the hedgehog protein family, signaling proteins involved in development. |
PTCH1, HHIP |
GO:0097109 | MF | neuroligin family protein binding | Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation. |
DLG4, NRXN1 |
GO:0097110 | MF | scaffold protein binding | Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. |
MAP3K7, CACNA1G, KRT18, KRT8, VIM, DSP, GJA1, ATP2B4, MAPK3, NOS3, MAP2K2, CAV2, DLG4, MDM2, PDE4D, KCNH2, CASP8, NLGN4X, NLGN1, PANX1, TREM1, CRIPT |
GO:0097111 | BP | endoplasmic reticulum-Golgi intermediate compartment organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment. |
GBF1 |
GO:0097112 | BP | gamma-aminobutyric acid receptor clustering | The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane. |
GLRB, GPHN |
GO:0097113 | BP | AMPA glutamate receptor clustering | The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane. |
APOE, DLG4, NLGN1 |
GO:0097114 | BP | NMDA glutamate receptor clustering | The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane. |
APOE, NLGN1 |
GO:0097115 | BP | neurexin clustering involved in presynaptic membrane assembly | The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals. |
NLGN1 |
GO:0097116 | BP | gephyrin clustering involved in postsynaptic density assembly | The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses. |
NRXN1 |
GO:0097118 | BP | neuroligin clustering involved in postsynaptic membrane assembly | The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons. |
CDH2, MAGI2, NRXN1 |
GO:0097119 | BP | postsynaptic density protein 95 clustering | The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. |
NLGN1, NRXN1 |
GO:0097120 | BP | receptor localization to synapse | Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. |
DLG4, DLG1, NLGN1 |
GO:0097136 | CC | Bcl-2 family protein complex | A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. |
BAX, MCL1 |
GO:0097144 | CC | BAX complex | An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators. |
BAX |
GO:0097149 | CC | centralspindlin complex | A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals). |
KIF23, RACGAP1, ECT2 |
GO:0097150 | BP | neuronal stem cell population maintenance | Any process in by an organism or tissue maintains a population of neuronal stem cells. |
FOXO3, CDH2, NOTCH1, JAG1, FOXO1, HES1, PCM1, HOOK3, ASPM, PROX1, FANCD2, MMP24 |
GO:0097151 | BP | positive regulation of inhibitory postsynaptic potential | Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. |
ABAT, IGSF9B, RIMS2 |
GO:0097152 | BP | mesenchymal cell apoptotic process | Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. |
TBX1 |
GO:0097153 | MF | cysteine-type endopeptidase activity involved in apoptotic process | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. |
CASP9, CASP6, CASP8, PYCARD |
GO:0097154 | BP | GABAergic neuron differentiation | The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. |
INHBA |
GO:0097155 | BP | fasciculation of sensory neuron axon | The collection of sensory neuron axons into a bundle of rods, known as a fascicle. |
EPHA3, EPHA4 |
GO:0097156 | BP | fasciculation of motor neuron axon | The collection of motor neuron axons into a bundle of rods, known as a fascicle. |
EPHA3, EPHA4 |
GO:0097157 | MF | pre-mRNA intronic binding | Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA). |
HNRNPL, HNRNPA2B1, SOX9, EP300, RNPC3, RBM4 |
GO:0097158 | MF | pre-mRNA intronic pyrimidine-rich binding | Interacting selectively and non-covalently with a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA). |
RBM4 |
GO:0097159 | MF | organic cyclic compound binding | Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. |
MTNR1A |
GO:0097161 | MF | DH domain binding | Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket. |
EPHA4 |
GO:0097165 | CC | nuclear stress granule | A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress. |
TIA1 |
GO:0097167 | BP | circadian regulation of translation | Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours. |
PER1, HNRNPD, RBM4 |
GO:0097169 | CC | AIM2 inflammasome complex | A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA. |
CASP1, CASP4, PYCARD |
GO:0097177 | MF | mitochondrial ribosome binding | Interacting selectively and non-covalently with any part of a mitochondrial ribosome, a ribosome found in the mitochondrion of a eukaryotic cell. |
C1QBP |
GO:0097178 | BP | ruffle assembly | The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. |
RAC1, ARHGEF26, INPP5K |
GO:0097181 | CC | protein C inhibitor-coagulation factor V complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V. |
SERPINA5 |
GO:0097182 | CC | protein C inhibitor-coagulation factor Xa complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa. |
SERPINA5 |
GO:0097183 | CC | protein C inhibitor-coagulation factor XI complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI. |
SERPINA5 |
GO:0097186 | BP | amelogenesis | The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. |
ITGB4, ITGA6, PERP, CSF3R |
GO:0097187 | BP | dentinogenesis | The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin. |
FAM20C, HTRA1 |
GO:0097190 | BP | apoptotic signaling pathway | A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. |
DAPL1, TLR4, HIP1, TNFRSF11B, TLR3, DAPK3, PDCD6, TNFRSF21, ANXA6, NGFR, CD14, CD28, PRKCA, TNFRSF1B, FAS, TNFRSF8, ADORA1, IFI27, DAP, DAP3, DAPK1, CAV1, PPARD, BAX, FADD, RIPK1, FASTK, CASP8, PTGIS, TNFRSF25, MOAP1, PAWR, P2RX4, MAP3K5, DIDO1, TM2D1, UACA, NDUFA13, TNFRSF11A |
GO:0097191 | BP | extrinsic apoptotic signaling pathway | A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
SIVA1, TLR3, JAK2, IL33, TGFB1, TNF, KRT18, KRT8, INHBA, IL6R, TNFRSF1B, FAS, CD27, G0S2, IL12A, ACVR1B, TGFB2, SMAD3, BAX, MLLT11, FADD, RIPK1, CASP8, TRADD, BAD, CIB1, TNFRSF12A, NDUFA13, PARP2 |
GO:0097192 | BP | extrinsic apoptotic signaling pathway in absence of ligand | A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. |
EYA2, BCL2L11, FOXO3, IL1A, IL1B, ITGAV, BCL2, KITLG, ERBB3, FAS, GSK3B, CASP9, BAX, MCL1, FADD, BCL2L2, BAD, MOAP1, MKNK2, BOK |
GO:0097193 | BP | intrinsic apoptotic signaling pathway | A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). |
DDX3X, NBN, NOL3, TP53, CD24, CDKN1A, PPM1F, CASP4, MSH6, CYCS, BAX, MLLT11, CUL2, CUL3, CUL4A, PMAIP1, BAD, CUL5, LGALS12, APOPT1, BBC3, HIPK2 |
GO:0097194 | BP | execution phase of apoptosis | A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
CFLAR, AKT1, CASP8, STK24 |
GO:0097195 | BP | pilomotor reflex | The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect. |
ADRA1A |
GO:0097197 | CC | tetraspanin-enriched microdomain | A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities. |
ADAM10, TSPAN14 |
GO:0097199 | MF | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway. |
CASP8 |
GO:0097200 | MF | cysteine-type endopeptidase activity involved in execution phase of apoptosis | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis. |
CFLAR |
GO:0097201 | BP | negative regulation of transcription from RNA polymerase II promoter in response to stress | Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). |
IMPACT |
GO:0097202 | BP | activation of cysteine-type endopeptidase activity | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. |
ASPH, FADD, CASP8, IFI16, BAD, CYFIP2, PERP, PYCARD |
GO:0097205 | BP | renal filtration | A renal system process in which fluid circulating through the body is filtered through a barrier system. |
ITGA3 |
GO:0097208 | CC | alveolar lamellar body | A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. |
CTSH, LAMP1, RAB7A |
GO:0097211 | BP | cellular response to gonadotropin-releasing hormone | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. |
GNRHR, MGARP |
GO:0097212 | BP | lysosomal membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
ARF1 |
GO:0097214 | BP | positive regulation of lysosomal membrane permeability | Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. |
MT3 |
GO:0097222 | BP | mitochondrial mRNA polyadenylation | The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails. |
PNPT1 |
GO:0097225 | CC | sperm midpiece | The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. |
SQSTM1, IFT81, PACRG, IFT27 |
GO:0097226 | CC | sperm mitochondrial sheath | The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. |
HSP90AA1 |
GO:0097228 | CC | sperm principal piece | The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. |
HK1, ATP2B4, SPA17, ENKUR, IFT81, IFT27 |
GO:0097233 | CC | alveolar lamellar body membrane | The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. |
LAMP3 |
GO:0097237 | BP | cellular response to toxic substance | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
PARK2, ABTB2, PINK1 |
GO:0097238 | BP | cellular response to methylglyoxal | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal. |
AKR1B1 |
GO:0097241 | BP | hematopoietic stem cell migration to bone marrow | The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. |
GPLD1, GAS6 |
GO:0097252 | BP | oligodendrocyte apoptotic process | Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons. |
TNFRSF21, TP53 |
GO:0097255 | CC | R2TP complex | A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others. |
RPAP3, RUVBL2, RUVBL1 |
GO:0097260 | MF | eoxin A4 synthase activity | Catalysis of the reaction: leukotriene A4 = eoxin A4. |
ALOX15 |
GO:0097264 | BP | self proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. |
CAPN3, TENM4, TMPRSS6, TENM3 |
GO:0097267 | BP | omega-hydroxylase P450 pathway | The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. |
CYP1A1, CYP2C9, CYP1B1, CYP2U1 |
GO:0097274 | BP | urea homeostasis | Any biological process involved in the maintenance of an internal steady state of urea. |
SLC25A23 |
GO:0097278 | BP | complement-dependent cytotoxicity | Lysis of a cell resulting from triggering of the complement cascade. An example can be seen with complement activation and subsequent lysis of a bacterial cell as a result of the binding of IgM to the cell surface followed by the binding of complement proteins to that antibody. |
RAB27A |
GO:0097284 | BP | hepatocyte apoptotic process | Any apoptotic process in a hepatocyte, the main structural component of the liver. |
KRT18, KRT8, RB1, FAS, PIK3CG, BID, STK4 |
GO:0097286 | BP | iron ion import | The directed movement of iron ions into a cell or organelle. |
TFRC, MFI2 |
GO:0097296 | BP | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. |
JAK2, FAS, TNFSF10, SMAD3, BAX, FADD, RIPK1, CASP8, TRADD |