GO:0090263

BP

positive regulation of canonical Wnt signaling pathway

Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

PSMD11, PSMD12, ARNTL, AXIN1, PSMD3, DAPK3, LGR5, LRP6, PSMD10, UBR5, TNKS, CTDNEP1, COL1A1, WNT2, UBC, JUP, PSMC3, NFKB1, PSMB1, FGFR2, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, FGF9, PSMC2, PSMB10, PSMC4, YAP1, CSNK1D, CSNK1E, PSMB3, PSMD7, DLX5, PSME3, PSMC1, PSMC6, RPS27A, UBA52, XIAP, CAV1, SOX4, BAMBI, PSMD2, ILK, PSME4, DIXDC1, WLS, TMEM198, SFRP4, USP34, SULF2, ASPM, CCAR2, SFRP1, TRPM4, WNT2B, ZBED3, VPS35, LGR4, RSPO3, TNKS2, SMURF2, LGR6, RNF146, GPRC5B, DKK2

GO:0090265

BP

positive regulation of immune complex clearance by monocytes and macrophages

Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.

CCL2

GO:0090266

BP

regulation of mitotic cell cycle spindle assembly checkpoint

Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.

CCNB1, DUSP1, USP44, LCMT1

GO:0090267

BP

positive regulation of mitotic cell cycle spindle assembly checkpoint

Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.

NDC80, TPR, MAD2L1

GO:0090271

BP

positive regulation of fibroblast growth factor production

Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

PTGS2, HEG1

GO:0090272

BP

negative regulation of fibroblast growth factor production

Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

FGFR1, RGCC

GO:0090274

BP

positive regulation of somatostatin secretion

Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.

SCT

GO:0090277

BP

positive regulation of peptide hormone secretion

Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.

INS, FGA, FGB, FGG, HFE, RASL10B, TFR2

GO:0090279

BP

regulation of calcium ion import

Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.

CTNNB1, PKD2, HOMER1, WNK3

GO:0090280

BP

positive regulation of calcium ion import

Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.

CASK, GRM6, PDGFB, GCG, PDGFRB, CCL3, CCL2, LGALS3, ZP3, CXCL12, STC1, TRPV2

GO:0090281

BP

negative regulation of calcium ion import

Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.

SPINK1, PLN, SLC30A1

GO:0090285

BP

negative regulation of protein glycosylation in Golgi

Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus.

TMEM59

GO:0090286

BP

cytoskeletal anchoring at nuclear membrane

The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane.

SYNE2, SPAG4, SUN2

GO:0090287

BP

regulation of cellular response to growth factor stimulus

Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.

FBN1, FBN2, FBN3

GO:0090288

BP

negative regulation of cellular response to growth factor stimulus

Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.

CASK, SLIT2

GO:0090290

BP

positive regulation of osteoclast proliferation

Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.

PTH

GO:0090291

BP

negative regulation of osteoclast proliferation

Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.

GREM1, TNFAIP3

GO:0090292

BP

nuclear matrix anchoring at nuclear membrane

The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane.

SUN2

GO:0090298

BP

negative regulation of mitochondrial DNA replication

Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.

PID1

GO:0090303

BP

positive regulation of wound healing

Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

VTN, ANXA1, INSL3, KANK1, MYLK, HBEGF

GO:0090305

BP

nucleic acid phosphodiester bond hydrolysis

The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.

ZC3H12D, EME2, ENPP3, RAD1, REV3L, DXO, TDP2, POLA1, RAG1, ENPP1, MRE11A, DNA2, POLG, POLE, G3BP1, ENPP2, TSN, TATDN3, ZC3H12B, TATDN1, RAD9B, PGAP1, FANCM, XRN1, REXO1, RAD50, EME1, DCLRE1C, RAD9A, TREX2, MGME1, PELO, ZC3H12C, TDP1, EXOG

GO:0090306

BP

spindle assembly involved in meiosis

The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis.

GOLGA2, ASPM

GO:0090307

BP

mitotic spindle assembly

The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis.

ARHGEF10, BIRC5, ZNF207, MYBL2, FLNA, NEK2, KIF11, RHOA, RAB11A, GOLGA2, MZT1, KPNB1, FAM175B, MAP9, PIBF1, TUBGCP3, KIFC1, WRAP73, TPX2

GO:0090308

BP

regulation of methylation-dependent chromatin silencing

Any process that modulates the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.

UHRF2, UHRF1

GO:0090309

BP

positive regulation of methylation-dependent chromatin silencing

Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.

DNMT1, TRIM28

GO:0090311

BP

regulation of protein deacetylation

Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.

SPRED1, CCAR2

GO:0090314

BP

positive regulation of protein targeting to membrane

Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.

MYO1C, ITGB1BP1, ERBB2, CCL2, STOM, AKT2, CDK5, ANK3, C2CD5, CEMIP, MIEF2, CHP1, CIB1, MFF, TCAF1

GO:0090315

BP

negative regulation of protein targeting to membrane

Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.

ITGB1BP1, GDI1, INPP5K

GO:0090316

BP

positive regulation of intracellular protein transport

Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.

RAB29, OAZ2, PCNT, TPR, OAZ1, CDC42, VAMP2, PCM1, RUFY3, KIF20B, RBM22

GO:0090317

BP

negative regulation of intracellular protein transport

Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.

ADIPOQ

GO:0090324

BP

negative regulation of oxidative phosphorylation

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

PPIF

GO:0090325

BP

regulation of locomotion involved in locomotory behavior

Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.

DRD2

GO:0090327

BP

negative regulation of locomotion involved in locomotory behavior

Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.

ARRDC3

GO:0090330

BP

regulation of platelet aggregation

Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.

LYN, PRKCA, SYK, PRKCQ

GO:0090331

BP

negative regulation of platelet aggregation

Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.

SERPINE2, ABAT, PRKCD, ADAMTS18, UBASH3B, C1QTNF1

GO:0090335

BP

regulation of brown fat cell differentiation

Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.

LEP, FTO, DUSP10

GO:0090336

BP

positive regulation of brown fat cell differentiation

Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.

INS, PTGS2, MAPK14

GO:0090340

BP

positive regulation of secretion of lysosomal enzymes

Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.

NR1H2

GO:0090341

BP

negative regulation of secretion of lysosomal enzymes

Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.

NR1H3

GO:0090343

BP

positive regulation of cell aging

Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan.

LMNA

GO:0090344

BP

negative regulation of cell aging

Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan.

MIF, PTEN, FOXM1, FZR1

GO:0090350

BP

negative regulation of cellular organofluorine metabolic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells.

CYP2D6

GO:0090361

BP

regulation of platelet-derived growth factor production

Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

NDRG2

GO:0090362

BP

positive regulation of platelet-derived growth factor production

Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

PTGS2

GO:0090370

BP

negative regulation of cholesterol efflux

Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.

SREBF2

GO:0090382

BP

phagosome maturation

A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.

RAB7A, RAB31, RAB32, RAB34

GO:0090383

BP

phagosome acidification

Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion.

ATP6V0E1, ATP6V1G1, ATP6V1G2, ATP6V1B2, ATP6V1C1, RAB7A, ATP6V0D1, TCIRG1, ATP6V1F, ATP6V1C2, ATP6V0A1, ATP6V1H, ATP6V1D

GO:0090385

BP

phagosome-lysosome fusion

The creation of a phagolysosome from a phagosome and a lysosome.

RAB7A, RAB34

GO:0090394

BP

negative regulation of excitatory postsynaptic potential

Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.

NPY2R, PTEN, MTMR2, NLGN4X

GO:0090398

BP

cellular senescence

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

OPA1, H2AFX, CALR, CDKN1A, ID2, MAP2K1, PRKCD, SMC5, KAT6A, PRMT6, SMC6

GO:0090399

BP

replicative senescence

A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.

CHEK1, TP53, MME, CDKN1A

GO:0090400

BP

stress-induced premature senescence

A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.

CDKN1A, MAPK14

GO:0090402

BP

oncogene-induced cell senescence

A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family.

HMGA1, HMGA2

GO:0090403

BP

oxidative stress-induced premature senescence

A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals.

ARNTL, TP53

GO:0090425

BP

acinar cell differentiation

The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini.

PROX1

GO:0090450

MF

inosine-diphosphatase activity

Catalysis of the reaction: IDP + H2O = IMP + phosphate.

NUDT16

GO:0090481

BP

pyrimidine nucleotide-sugar transmembrane transport

The directed movement of pyrimidine nucleotide-sugars across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.

SLC35D2, SLC35D1

GO:0090498

CC

extrinsic component of Golgi membrane

The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

NUCB1, HID1

GO:0090500

BP

endocardial cushion to mesenchymal transition

A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

HAS2

GO:0090501

BP

RNA phosphodiester bond hydrolysis

The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis.

ANG, AZGP1, SMG5

GO:0090502

BP

RNA phosphodiester bond hydrolysis, endonucleolytic

The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.

RNASET2, KIAA0391, ERN1, RNASEH2A, POP7, RPP40, POP4, RNASE1, RNASE2, RNASE4, FEN1, HRSP12, RPP30, RNASEL, LACTB2, RNASEH2B, RNASEK, ZC3H3, TSEN15, POP5, EDC3, RPP25, MRPL44, AGO2, NOB1, DICER1, EXO1

GO:0090503

BP

RNA phosphodiester bond hydrolysis, exonucleolytic

The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.

CNOT1, PARN, PAN3, DCP2, PNPT1, ISG20, EXOSC4, CNOT7, NOCT, CNOT6, DIS3, REXO2

GO:0090521

BP

glomerular visceral epithelial cell migration

The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.

NUP93, ANLN

GO:0090526

BP

regulation of gluconeogenesis involved in cellular glucose homeostasis

Any process that modulates the frequency, rate or extent of gluconeogenesis as an integral part of cellular glucose homeostasis.

OGT, RANBP2, SESN2

GO:0090527

BP

actin filament reorganization

A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments.

FRY

GO:0090534

CC

calcium ion-transporting ATPase complex

Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in).

PLN

GO:0090537

CC

CERF complex

An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters.

SMARCA1

GO:0090541

MF

MIT domain binding

Interacting selectively and non-covalently with the MIT domain of a protein. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.

IST1

GO:0090543

CC

Flemming body

A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.

VPS4B, NUP62, CAPG, IST1

GO:0090544

CC

BAF-type complex

A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family.

PBRM1, BRD7

GO:0090554

MF

phosphatidylcholine-translocating ATPase activity

Catalysis of the movement of phosphatidylcholine from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.

ABCA1

GO:0090556

MF

phosphatidylserine-translocating ATPase activity

Catalysis of the movement of phosphatidylserine from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.

ABCA1

GO:0090557

BP

establishment of endothelial intestinal barrier

The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.

TJP1, TJP2, F11R

GO:0090559

BP

regulation of membrane permeability

Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane.

TJP2, F11R

GO:0090571

CC

RNA polymerase II transcription repressor complex

A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter.

DDX20

GO:0090575

CC

RNA polymerase II transcription factor complex

A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II.

NR5A2, VDR, TCF3, HMGA1, SFPQ, ARNT, PPARG, STAT3, GATA4, ASCL1, HYAL2, NR1H3, TRIM28, NONO, HIF1A, CARM1, TCF12, HNRNPAB, HIPK2

GO:0090611

BP

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination.

VPS4B, PDCD6IP, CHMP4B

GO:0090624

MF

endoribonuclease activity, cleaving miRNA-paired mRNA

Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA.

AGO2

GO:0090625

BP

mRNA cleavage involved in gene silencing by siRNA

The process in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.

AGO2

GO:0090630

BP

activation of GTPase activity

Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

TAX1BP3, ARHGEF10, TBC1D4, TBC1D12, TBC1D8, TBC1D3H, AKT2, WNT5A, EIF5, TBC1D8B, TIAM1, RALGAPA2, RABGAP1L, GRTP1, ARHGEF16, TBC1D9B, RALGAPA1, TBC1D3C, TBC1D9, SYDE1, RALGAPB, TBC1D3, TBC1D16, TBC1D15, TBC1D5, USP6NL, RUNDC1, EVI5L, DOCK7, NDEL1, ECT2, TBC1D14, CORO1C, TBC1D2B, RABGAP1

GO:0090646

BP

mitochondrial tRNA processing

The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion.

KIAA0391, HSD17B10, ELAC2

GO:0090650

BP

cellular response to oxygen-glucose deprivation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose.

AIFM1

GO:0090656

BP

t-circle formation

A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).

ERCC1

GO:0090661

CC

box H/ACA telomerase RNP complex

A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell.

DKC1, NOP10, GAR1

GO:0090662

BP

ATP hydrolysis coupled transmembrane transport

The transport of molecules across a membrane and against an electrochemical gradient, using energy from ATP hydrolysis.

ATP1B1, ATP1B3

GO:0090666

BP

scaRNA localization to Cajal body

A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body.

TCP1, CCT2

GO:0090669

BP

telomerase RNA stabilization

Prevention of degradation of telomerase RNA (TERC) molecules.

DKC1

GO:0090675

BP

intermicrovillar adhesion

The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.

CDHR2

GO:0097003

MF

adipokinetic hormone receptor activity

Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.

ADIPOR2, ADIPOR1

GO:0097006

BP

regulation of plasma lipoprotein particle levels

Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism.

LPCAT3, DGAT2

GO:0097009

BP

energy homeostasis

Any process involved in the balance between food intake (energy input) and energy expenditure.

ACACB, EDN2, STAT3, PIK3CA, LEPR, AMPD3, MEX3C, CRTC3, NR4A3, OMA1, MRAP2

GO:0097010

BP

eukaryotic translation initiation factor 4F complex assembly

The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex.

EIF4B

GO:0097011

BP

cellular response to granulocyte macrophage colony-stimulating factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.

NPR2, ZFP36, MAPK1, AKT1, ZFP36L2

GO:0097016

MF

L27 domain binding

Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner.

DLG1, LIN7C

GO:0097020

MF

COPII adaptor activity

The binding activity of a molecule that brings together the COPII vesicle proteins and one or more other molecules, permitting them to function in a coordinated way.

TEX261

GO:0097025

CC

MPP7-DLG1-LIN7 complex

A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions.

DLG1, LIN7C

GO:0097027

MF

ubiquitin-protein transferase activator activity

Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.

RING1, CDC20, FZR1

GO:0097028

BP

dendritic cell differentiation

The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.

LYN, GAS6, LILRB1, AZI2

GO:0097029

BP

mature conventional dendritic cell differentiation

The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells.

F2RL1

GO:0097033

BP

mitochondrial respiratory chain complex III biogenesis

The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together.

UQCC3