GO:0072193

BP

ureter smooth muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter.

BMP4, SOX9

GO:0072197

BP

ureter morphogenesis

The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder.

SOX9, SOX8

GO:0072198

BP

mesenchymal cell proliferation involved in ureter development

The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development.

BMP4

GO:0072200

BP

negative regulation of mesenchymal cell proliferation involved in ureter development

Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.

BMP4

GO:0072201

BP

negative regulation of mesenchymal cell proliferation

Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.

LMNA, WNT5A

GO:0072202

BP

cell differentiation involved in metanephros development

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state.

LGR4

GO:0072203

BP

cell proliferation involved in metanephros development

The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros.

PTCH1

GO:0072205

BP

metanephric collecting duct development

The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder.

BMP4, AQP2, PKD1, DLG5

GO:0072207

BP

metanephric epithelium development

The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.

WT1, PAX8, OSR1

GO:0072208

BP

metanephric smooth muscle tissue development

The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure.

PKD2, OSR1

GO:0072214

BP

metanephric cortex development

The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros.

PKD2

GO:0072218

BP

metanephric ascending thin limb development

The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent.

PKD1, PKD2

GO:0072219

BP

metanephric cortical collecting duct development

The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex.

PKD2

GO:0072221

BP

metanephric distal convoluted tubule development

The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter.

PAX8

GO:0072224

BP

metanephric glomerulus development

The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros.

LGR4

GO:0072234

BP

metanephric nephron tubule development

The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros.

OSR1

GO:0072235

BP

metanephric distal tubule development

The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule.

PKD2

GO:0072237

BP

metanephric proximal tubule development

The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology.

PKD1

GO:0072239

BP

metanephric glomerulus vasculature development

The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus.

OSR1

GO:0072255

BP

metanephric glomerular mesangial cell development

The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure.

PDGFB

GO:0072259

BP

metanephric interstitial fibroblast development

The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure.

OSR1

GO:0072262

BP

metanephric glomerular mesangial cell proliferation involved in metanephros development

The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population.

PDGFRB

GO:0072268

BP

pattern specification involved in metanephros development

Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate.

OSR1

GO:0072277

BP

metanephric glomerular capillary formation

The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.

TCF21, PDGFRB, PDGFRA

GO:0072278

BP

metanephric comma-shaped body morphogenesis

The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros.

PDGFRB, PAX8

GO:0072282

BP

metanephric nephron tubule morphogenesis

The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros.

HES1, LGR4

GO:0072284

BP

metanephric S-shaped body morphogenesis

The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.

PDGFRB, WT1, PAX8, PKD2

GO:0072287

BP

metanephric distal tubule morphogenesis

The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule.

PKD1

GO:0072289

BP

metanephric nephron tubule formation

The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros.

SOX9, SOX8, PAX8

GO:0072300

BP

positive regulation of metanephric glomerulus development

Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros.

AGTR2

GO:0072302

BP

negative regulation of metanephric glomerular mesangial cell proliferation

Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.

WT1

GO:0072303

BP

positive regulation of glomerular metanephric mesangial cell proliferation

Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.

EGR1

GO:0072305

BP

negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros.

PAX8

GO:0072307

BP

regulation of metanephric nephron tubule epithelial cell differentiation

Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.

LIF, YAP1, PAX8

GO:0072320

MF

volume-sensitive chloride channel activity

Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.

CLCN3, TTYH1

GO:0072321

BP

chaperone-mediated protein transport

The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins.

TOR1A

GO:0072332

BP

intrinsic apoptotic signaling pathway by p53 class mediator

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.

TP53, DDX5, HINT1, FHIT, E2F1, BAX, TP53BP2, PMAIP1, E2F2, STK11, IFI16, ZNF385B, ZMAT1, PERP, MYBBP1A, PYCARD, BOK

GO:0072334

BP

UDP-galactose transmembrane transport

The directed movement of UDP-galactose across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

SLC35A2

GO:0072341

MF

modified amino acid binding

Interacting selectively and non-covalently with a modified amino acid.

CBS, MTHFR, NOX4

GO:0072344

BP

rescue of stalled ribosome

A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.

ICT1, C12orf65

GO:0072345

MF

NAADP-sensitive calcium-release channel activity

Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts.

TPCN2

GO:0072354

MF

histone kinase activity (H3-T3 specific)

Catalysis of the transfer of a phosphate group to the threonine-3 residue of the N-terminal tail of histone H3.

GSG2, VRK1

GO:0072355

BP

histone H3-T3 phosphorylation

The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 3 of the histone.

VRK1

GO:0072357

CC

PTW/PP1 phosphatase complex

A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

PPP1R12A, TOX4, PPP1CC, PPP1CA, PPP1CB, PPP1R10

GO:0072358

BP

cardiovascular system development

The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels.

NDUFS6

GO:0072362

BP

regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of glycolysis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.

NCOR1

GO:0072363

BP

regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of glycolysis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.

PPARA

GO:0072365

BP

regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.

NCOR2

GO:0072366

BP

regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.

PPARA

GO:0072368

BP

regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.

NCOR1, SREBF2

GO:0072369

BP

regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of lipid transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.

PPARA

GO:0072372

CC

primary cilium

A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors.

UNC119B, PDE6D, TULP3, RP2, GLI3, CSNK1A1, DYNLL1, PKD1, PDE4C, PTCH1, SPA17, CFAP126, NPHP3, NEK8, AHI1, FLCN, DYNC2LI1, IFT81, KIFAP3, CLUAP1, WDR34, IFT43, IFT74, IFT27, IFT122, IFT46, INPP5E, WDR35, DCDC2, SUFU, KIF3A, FAM179B, HSPB11

GO:0072377

BP

blood coagulation, common pathway

A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex.

FGA

GO:0072378

BP

blood coagulation, fibrin clot formation

A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.

FGA, FGB, FGG, FBLN1

GO:0072383

BP

plus-end-directed vesicle transport along microtubule

The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

KIF23, KIFAP3, KIF3A

GO:0072384

BP

organelle transport along microtubule

The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.

CDC42, ARHGAP21, LOH12CR1, COPG1

GO:0072385

BP

minus-end-directed organelle transport along microtubule

The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.

BICD2, BICD1

GO:0072389

BP

flavin adenine dinucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.

VCP

GO:0072393

BP

microtubule anchoring at microtubule organizing center

Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center.

BICD2, BICD1

GO:0072422

BP

signal transduction involved in DNA damage checkpoint

A signal transduction process that contributes to a DNA damage checkpoint.

CDC5L, PRPF19

GO:0072429

BP

response to intra-S DNA damage checkpoint signaling

A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling.

FBXO18, EME1

GO:0072431

BP

signal transduction involved in mitotic G1 DNA damage checkpoint

A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint.

PRKDC

GO:0072487

CC

MSL complex

A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.

MSL1

GO:0072488

BP

ammonium transmembrane transport

The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+.

SLC22A1, SLC12A2, RHBG

GO:0072498

BP

embryonic skeletal joint development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure.

EXT1, OSR1

GO:0072513

BP

positive regulation of secondary heart field cardioblast proliferation

Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).

GNG5

GO:0072517

CC

host cell viral assembly compartment

A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place.

BICD1

GO:0072518

MF

Rho-dependent protein serine/threonine kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires binding of the GTPase Rho.

ROCK2

GO:0072520

BP

seminiferous tubule development

The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.

AR, ATRX, SMAD4, KIF18A, WDR48, ADGRG1

GO:0072531

BP

pyrimidine-containing compound transmembrane transport

The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof.

AQP9, SLC28A3

GO:0072534

CC

perineuronal net

A dense extracellular matrix (ECM) structure that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.

TNR

GO:0072536

CC

interleukin-23 receptor complex

A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.

IL12RB1

GO:0072537

BP

fibroblast activation

A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.

RGCC

GO:0072539

BP

T-helper 17 cell differentiation

The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.

RORA

GO:0072540

BP

T-helper 17 cell lineage commitment

The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.

IL6

GO:0072542

MF

protein phosphatase activator activity

Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

CALM2

GO:0072546

CC

ER membrane protein complex

A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.

EMC2, EMC1, EMC3

GO:0072553

BP

terminal button organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.

SNAPIN, CHD4, NLGN1

GO:0072554

BP

blood vessel lumenization

The process in which a developing blood vessel forms an endothelial lumen through which blood will flow.

DLL4

GO:0072557

CC

IPAF inflammasome complex

A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri.

CASP1, CASP4

GO:0072558

CC

NLRP1 inflammasome complex

A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.

CASP1, PYCARD

GO:0072559

CC

NLRP3 inflammasome complex

A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.

CASP1, CASP4, PYCARD

GO:0072562

CC

blood microparticle

A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.

IGLL5, CLIC1, SDCBP, CD5L, F13A1, F2, C1R, HP, PLG, CFB, SERPINC1, SERPINA3, AGT, A2M, C3, KNG1, TGFB1, APOA1, APOE, APOA2, FGA, FGB, FGG, APCS, FN1, AMBP, ORM1, AHSG, ALB, GC, TFRC, TF, VTN, A1BG, KRT1, SERPING1, C8G, PRSS1, PFN1, CFH, C1S, C4A, C4B, HSPA1A, HSPA1B, CLU, SLC2A1, HSPA6, ORM2, STOM, PON1, HSPA1L, ACTB, YWHAZ, ACTG1, ACTG2, ACTC1, HBB, HBA1, CFHR1, FCN2, CPSF3L, APOA5, POTEE, ZBTB38

GO:0072563

CC

endothelial microparticle

A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell.

ANXA5

GO:0072572

MF

poly-ADP-D-ribose binding

Interacting selectively and non-covalently with polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring.

RNF146

GO:0072573

BP

tolerance induction to lipopolysaccharide

Tolerance induction directed at lipopolysaccharide antigens.

TNFAIP3

GO:0072574

BP

hepatocyte proliferation

The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.

CEBPB, RPS6KA1, PROX1

GO:0072576

BP

liver morphogenesis

The process in which the anatomical structures of the liver are generated and organized.

CUL3

GO:0072577

BP

endothelial cell apoptotic process

Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.

IL10, COL4A3, BMPR2, MAP3K5

GO:0072579

BP

glycine receptor clustering

The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane.

GPHN

GO:0072583

BP

clathrin-dependent endocytosis

An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.

HIP1, PIP5K1C, AP2A2, CLTA, CANX, AP2S1, AP2B1, FCHO2, PICALM, FNBP1L, AP2M1

GO:0072584

BP

caveolin-mediated endocytosis

An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers.

MAPK3, MAPK1, CAV1

GO:0072589

CC

box H/ACA scaRNP complex

A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs.

DKC1, NOP10, GAR1

GO:0072590

MF

N-acetyl-L-aspartate-L-glutamate ligase activity

Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate.

RIMKLB

GO:0072591

MF

citrate-L-glutamate ligase activity

Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate.

RIMKLB

GO:0072592

BP

oxygen metabolic process

The chemical reactions and pathways involving diatomic oxygen (O2).

ME3, FMO2

GO:0072593

BP

reactive oxygen species metabolic process

The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.

CYR61, NDUFS4, PDGFB, BCL2, VAV1, NDUFS1, CTGF, SESN2, AOX1, BNIP3, PRDX4, PMAIP1, PDK4, NDUFAF2, RFK, NOX4, DDIT4, NDUFA13, SESN1

GO:0072594

BP

establishment of protein localization to organelle

The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.

LAMP1, RAB11A, IFT122

GO:0072599

BP

establishment of protein localization to endoplasmic reticulum

The directed movement of a protein to a specific location in the endoplasmic reticulum.

RYR2

GO:0072600

BP

establishment of protein localization to Golgi

The directed movement of a protein to a specific location in the Golgi apparatus.

NRAS