Search Geneontologies

Geneontologies

GO ID Ontology GO Term Term Definition Proteins

GO:0071532

MF

ankyrin repeat binding

Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.

RELA

GO:0071535

MF

RING-like zinc finger domain binding

Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain.

UBE2I

GO:0071539

BP

protein localization to centrosome

A process in which a protein is transported to, or maintained at, the centrosome.

AURKA, CSNK1D, DCTN2, PCM1, STIL, CCDC14, HOOK3, PIBF1, SPAG5, CEP83

GO:0071540

CC

eukaryotic translation initiation factor 3 complex, eIF3e

An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.

EIF3A

GO:0071541

CC

eukaryotic translation initiation factor 3 complex, eIF3m

An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.

EIF3B, EIF3A

GO:0071542

BP

dopaminergic neuron differentiation

The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.

LRP6, VEGFA, OTX2, NR4A2, HIF1A, SFRP1

GO:0071543

BP

diphosphoinositol polyphosphate metabolic process

The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached.

NUDT10, NUDT11

GO:0071544

BP

diphosphoinositol polyphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached.

NUDT3

GO:0071547

CC

piP-body

A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.

PIWIL4, TDRD9

GO:0071548

BP

response to dexamethasone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.

FOXO3, EDN1, PCNA, PTAFR, PCK2

GO:0071549

BP

cellular response to dexamethasone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.

MSTN, EGFR, ASS1, TGFB1, IL6, CCL2, SRD5A1, SERPINF1, STAR, AGTR2, CASP9, RPL32, HNRNPU, FOXO1, FBXO32, SMYD3, DNMT3B, ERRFI1

GO:0071550

BP

death-inducing signaling complex assembly

A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway.

TNF, RAF1, FADD, RIPK1, CASP8, TRADD

GO:0071554

BP

cell wall organization or biogenesis

A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.

SPATA20

GO:0071556

CC

integral component of lumenal side of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.

HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, HLA-E, HLA-DRB4, HLA-G, HLA-DPA1, CALR, CANX, HLA-A, HLA-F, BCAP31, HLA-DRB3, PKD2, HLA-DRB5, SPPL3, SPPL2A, HM13

GO:0071557

BP

histone H3-K27 demethylation

The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.

UTY, KDM6A, KDM7A

GO:0071558

MF

histone demethylase activity (H3-K27 specific)

Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.

UTY, KDM6A, KDM7A

GO:0071559

BP

response to transforming growth factor beta

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.

SMAD4, RUNX3, ZFHX3, CITED1

GO:0071560

BP

cellular response to transforming growth factor beta stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.

PDCD5, SMAD7, TGFB1, PENK, COL1A1, EDN1, CLEC3B, FYN, COL4A2, WNT2, FBN1, SOX6, TGFBR1, WNT5A, ZFP36L2, LIMS1, SOX9, STAR, CAV1, MEF2C, ZFP36L1, HYAL2, MAPK7, PDE3A, POSTN, ANKRD1, SFRP1, HDAC2, PDGFD, NOX4, PPARGC1A

GO:0071561

CC

nucleus-vacuole junction

An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.

PIK3R4

GO:0071564

CC

npBAF complex

A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.

ARID1A, ACTL6A, SMARCA2, SMARCA4, SMARCD3, SMARCC2, PHF10, SMARCC1, SMARCD1

GO:0071565

CC

nBAF complex

A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

ARID1A, SMARCA2, SMARCA4, SMARCD3, ARID1B, SMARCC2, DPF3, SMARCC1, SMARCD1

GO:0071566

MF

UFM1 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond.

UBA5

GO:0071567

MF

UFM1 hydrolase activity

Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates.

UFSP2

GO:0071569

BP

protein ufmylation

Covalent attachment of the ubiquitin-like protein UFM1 to another protein.

UFM1, UBA5

GO:0071577

BP

zinc II ion transmembrane transport

A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

SLC39A6, SLC39A14, SLC30A8, SLC30A1

GO:0071578

BP

zinc II ion transmembrane import

The directed movement of zinc II ions across a membrane into a cell or organelle.

SLC39A6, SLC39A14, SLC39A4, SLC39A8, SLC39A10

GO:0071584

BP

negative regulation of zinc ion transmembrane import

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other.

SLC30A1

GO:0071585

BP

detoxification of cadmium ion

Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion.

SLC30A1

GO:0071586

BP

CAAX-box protein processing

The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis.

RCE1

GO:0071593

BP

lymphocyte aggregation

The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules.

RAC2

GO:0071595

CC

Nem1-Spo7 phosphatase complex

A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p.

CTDNEP1, CNEP1R1

GO:0071596

BP

ubiquitin-dependent protein catabolic process via the N-end rule pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.

UBR3, UBR1

GO:0071598

CC

neuronal ribonucleoprotein granule

A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.

PQBP1, FMR1, UHMK1

GO:0071599

BP

otic vesicle development

The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear.

PAX8, AHI1

GO:0071603

BP

endothelial cell-cell adhesion

The attachment of an endothelial cell to another endothelial cell via adhesion molecules.

JUP, THBS4, CYP1B1

GO:0071609

BP

chemokine (C-C motif) ligand 5 production

The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

TUSC2

GO:0071621

BP

granulocyte chemotaxis

The movement of a granulocyte in response to an external stimulus.

ANXA1, CCL3

GO:0071622

BP

regulation of granulocyte chemotaxis

Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.

CAMK1D

GO:0071624

BP

positive regulation of granulocyte chemotaxis

Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.

S100A7

GO:0071625

BP

vocalization behavior

The behavior in which an organism produces sounds by a mechanism involving its respiratory system.

SRPX2, DLG4, NLGN4X, NRXN1

GO:0071629

BP

cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation.

RNF126

GO:0071636

BP

positive regulation of transforming growth factor beta production

Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta.

CD46, PTGS2

GO:0071638

BP

negative regulation of monocyte chemotactic protein-1 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.

SOCS5, APOD, GSTP1, NR1H4, C1QTNF3

GO:0071639

BP

positive regulation of monocyte chemotactic protein-1 production

Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.

IL1A, IL1B, TWIST1, ADIPOQ, TRPV4

GO:0071642

BP

positive regulation of macrophage inflammatory protein 1 alpha production

Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha.

TRPV4

GO:0071650

BP

negative regulation of chemokine (C-C motif) ligand 5 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5.

IL10

GO:0071651

BP

positive regulation of chemokine (C-C motif) ligand 5 production

Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5.

DDX3X, MAVS, TRPV4

GO:0071660

BP

positive regulation of IP-10 production

Any process that activates or increases the frequency, rate, or extent of production of IP-10.

MAVS

GO:0071663

BP

positive regulation of granzyme B production

Any process that activates or increases the frequency, rate, or extent of production of granzyme B.

CD244

GO:0071665

CC

gamma-catenin-TCF7L2 complex

A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.

JUP

GO:0071670

BP

smooth muscle cell chemotaxis

The directed movement of a smooth muscle cell in response to an external stimulus.

PDGFRB, PARVA

GO:0071672

BP

negative regulation of smooth muscle cell chemotaxis

Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.

SLIT2, GSTP1, CORO1B

GO:0071673

BP

positive regulation of smooth muscle cell chemotaxis

Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis.

PDGFD

GO:0071674

BP

mononuclear cell migration

The movement of a mononuclear cell within or between different tissues and organs of the body.

LGALS3

GO:0071676

BP

negative regulation of mononuclear cell migration

Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.

SLIT2

GO:0071677

BP

positive regulation of mononuclear cell migration

Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.

TGFB1, TNF, LGALS3

GO:0071679

BP

commissural neuron axon guidance

The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.

NFIB, NRP1, VEGFA, EPHB2, DAG1

GO:0071681

BP

cellular response to indole-3-methanol

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus.

JUP, CTNNA1, CTNNB1, BRCA1

GO:0071682

CC

endocytic vesicle lumen

The volume enclosed by the membrane of an endocytic vesicle.

HP, APOA1, APOE, APOB, HSP90AA1, SPARC, SAA1, HSP90B1, CALR, HBB, HBA1, HSPH1, HYOU1

GO:0071691

BP

cardiac muscle thin filament assembly

The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle.

NEBL

GO:0071701

BP

regulation of MAPK export from nucleus

Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm.

DNAJC27

GO:0071709

BP

membrane assembly

The aggregation, arrangement and bonding together of a set of components to form a membrane.

SPTBN1, ANK3

GO:0071711

BP

basement membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.

FLRT2, SPINT2, NID1, MMP11, NID2, DAG1

GO:0071712

BP

ER-associated misfolded protein catabolic process

The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.

TOR1A, VCP, UFD1L, SDF2, UGGT1, POMT1

GO:0071723

MF

lipopeptide binding

Interacting selectively and non-covalently with a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.

CD1D, TLR1

GO:0071726

BP

cellular response to diacyl bacterial lipopeptide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus.

TLR2, CD14, CD36

GO:0071727

BP

cellular response to triacyl bacterial lipopeptide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus.

TLR2, CD14, TLR1

GO:0071732

BP

cellular response to nitric oxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.

AIFM1, CCNA2, CDK2, MT3, FOXO1, HNRNPD, MTR

GO:0071733

BP

transcriptional activation by promoter-enhancer looping

The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter.

RUVBL2

GO:0071763

BP

nuclear membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.

TOR1A, TMEM43

GO:0071765

BP

nuclear inner membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane.

TARDBP

GO:0071773

BP

cellular response to BMP stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.

SMAD9, SPINT2, BMP2, BMP4, BMP6, ACVR2A, BMPR1A, DLX5, ADAMTS12, ACVR1, SMAD4, BMPR2, RUNX2, SFRP1, GATA6, HEYL, ADAMTS7

GO:0071774

BP

response to fibroblast growth factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus.

PTH, ELK1, TNC, IER2

GO:0071782

CC

endoplasmic reticulum tubular network

A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section.

REEP5, KPNB1, RAB3GAP1, ATL3, LNP, REEP1

GO:0071786

BP

endoplasmic reticulum tubular network organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section.

TMEM170A, LNP, REEP1, RTN4

GO:0071787

BP

endoplasmic reticulum tubular network assembly

The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section.

ARL6IP1, RTN4

GO:0071797

CC

LUBAC complex

A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex.

PARK2

GO:0071799

BP

cellular response to prostaglandin D stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus.

TNC, AKR1C3, PTGFR, AKR1C2, PTGDR

GO:0071800

BP

podosome assembly

The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell.

SH3PXD2B, FARP2, BIN2

GO:0071803

BP

positive regulation of podosome assembly

Any process that activates or increases the rate or extent of podosome assembly.

TNF, LCP1, MAPK9, ARHGEF5, FSCN1

GO:0071805

BP

potassium ion transmembrane transport

A process in which a potassium ion is transported from one side of a membrane to the other.

KCNK1, KCNK3, CNGA1, FXYD4, KCNA1, KCNMA1, KCNH2, PKD2, KCNC3, KCNJ11, KCNG3, KCNV2, KCNE4, SLC9A6, KCNK17, KCNK12, KCNIP2, TMEM38B, SLC9A2, KCNG1, KCNK6

GO:0071806

BP

protein transmembrane transport

The directed movement of a protein across a membrane by means of some agent such as a transporter or pore.

AZGP1, SEC61G, NUTF2, MCL1

GO:0071812

BP

positive regulation of fever generation by positive regulation of prostaglandin secretion

Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell.

TNFSF11, TNFRSF11A

GO:0071813

MF

lipoprotein particle binding

Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.

APOE, MAPT, CD36, CDH13

GO:0071816

BP

tail-anchored membrane protein insertion into ER membrane

A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.

WRB

GO:0071817

CC

MMXD complex

A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation.

CIAO1, SLC25A5, ERCC2, FAM96B

GO:0071819

CC

DUBm complex

A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p.

ENY2

GO:0071820

MF

N-box binding

Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.

HES1

GO:0071821

CC

FANCM-MHF complex

A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes.

STRA13, FANCM, APITD1

GO:0071837

MF

HMG box domain binding

Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.

HOXA3, JUN, HOXC4, EGR2, MEOX1, DLX5, HHEX, MEF2C, TCF12

GO:0071838

BP

cell proliferation in bone marrow

The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow.

ACE

GO:0071847

BP

TNFSF11-mediated signaling pathway

A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

TNFSF11, TNFRSF11A

GO:0071848

BP

positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling

Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade.

TNFSF11, TNFRSF11A

GO:0071850

BP

mitotic cell cycle arrest

The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M).

GADD45A, DUSP1, CDKN1A, CDKN1B, MAGI2, MCPH1, GADD45GIP1, PNPT1, RGCC, CDC14A

GO:0071862

MF

protein phosphatase type 1 activator activity

Increases the activity of the enzyme protein phosphatase type 1.

PPP1R15A, PHACTR4

GO:0071864

BP

positive regulation of cell proliferation in bone marrow

A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.

PTH, IL6, MEF2C

GO:0071866

BP

negative regulation of apoptotic process in bone marrow

Any process that stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow.

PTH, HSPD1

GO:0071870

BP

cellular response to catecholamine stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.

GNB1, NR4A3

GO:0071871

BP

response to epinephrine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.

PENK, PPARGC1A

GO:0071872

BP

cellular response to epinephrine stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.

PRKACA, SRD5A1, ATP2B4, SNCA, STAR, PDE4D, ADIPOQ, SIRT2, RYR2

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