| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0003323 | BP | type B pancreatic cell development | The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. |
BMP4, BMP6, WNT5A, CDK6, INSM1 |
GO:0003331 | BP | positive regulation of extracellular matrix constituent secretion | Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. |
AGT, CPB2, RGCC |
GO:0003333 | BP | amino acid transmembrane transport | The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore. |
SLC6A6, PEX3, SLC7A9, SLC1A5, SLC38A9, SLC16A10, SLC38A5, SLC38A10, SLC6A14 |
GO:0003334 | BP | keratinocyte development | The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure. |
FLNB, FOSL2, SFN, CDC42, EXPH5, PALLD, IFT74 |
GO:0003337 | BP | mesenchymal to epithelial transition involved in metanephros morphogenesis | A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. |
GREM1, BMP4, PAX8 |
GO:0003338 | BP | metanephros morphogenesis | The process in which the anatomical structures of the metanephros are generated and organized. |
CTNNB1, FRAS1 |
GO:0003340 | BP | negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. |
CTNNB1, CITED1 |
GO:0003341 | BP | cilium movement | The directed, self-propelled movement of a cilium. |
CCDC42B, ARMC4, RSPH4A, DNAAF5, CCDC103, C6orf165, DNAH5, DNAH11, DNAI1 |
GO:0003342 | BP | proepicardium development | The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. |
ZFP36L1 |
GO:0003344 | BP | pericardium morphogenesis | The process in which the anatomical structure of the pericardium is generated and organized. |
LRP6, NOTCH1, SOS1, DLL4 |
GO:0003345 | BP | proepicardium cell migration involved in pericardium morphogenesis | The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart. |
FLRT3 |
GO:0003350 | BP | pulmonary myocardium development | The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein. |
PITX2, SEMA3C |
GO:0003351 | BP | epithelial cilium movement | The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid. |
TTLL1, SPA17, DNAH1 |
GO:0003356 | BP | regulation of cilium beat frequency | Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium. |
ARMC4, DNAH11 |
GO:0003357 | BP | noradrenergic neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline. |
SOX4 |
GO:0003358 | BP | noradrenergic neuron development | The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
ASCL1, INSM1 |
GO:0003359 | BP | noradrenergic neuron fate commitment | The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron. |
ASCL1 |
GO:0003360 | BP | brainstem development | The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. |
GART, SMAD4, NLGN4X |
GO:0003365 | BP | establishment of cell polarity involved in ameboidal cell migration | The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. |
AMOT, AMOTL1 |
GO:0003374 | BP | dynamin family protein polymerization involved in mitochondrial fission | The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission. |
OPA1 |
GO:0003376 | BP | sphingosine-1-phosphate signaling pathway | A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
EZR, S1PR1, S1PR3, SPHK1 |
GO:0003382 | BP | epithelial cell morphogenesis | The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. |
CLDN3, FLNB, AR, RAC1, PALLD |
GO:0003383 | BP | apical constriction | The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell. |
FRMD6 |
GO:0003401 | BP | axis elongation | The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. |
PTK7 |
GO:0003402 | BP | planar cell polarity pathway involved in axis elongation | The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation. |
WNT5A, MAGI2 |
GO:0003407 | BP | neural retina development | The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. |
ACTL6A, ATP2B1, ATP2B4, PSEN1, SMARCA4, TGFB2, SMARCD3 |
GO:0003408 | BP | optic cup formation involved in camera-type eye development | The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle. |
ARID1A, WNT5A |
GO:0003413 | BP | chondrocyte differentiation involved in endochondral bone morphogenesis | The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. |
SOX9, TRIP11 |
GO:0003415 | BP | chondrocyte hypertrophy | The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time. |
SOX9, MEX3C |
GO:0003416 | BP | endochondral bone growth | The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. |
EVC, BNC2 |
GO:0003417 | BP | growth plate cartilage development | The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. |
COMP |
GO:0003420 | BP | regulation of growth plate cartilage chondrocyte proliferation | Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. |
CARM1 |
GO:0003421 | BP | growth plate cartilage axis specification | The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth. |
STC1 |
GO:0003430 | BP | growth plate cartilage chondrocyte growth | The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another. |
TGFBR2 |
GO:0003433 | BP | chondrocyte development involved in endochondral bone morphogenesis | The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. |
SERPINH1 |
GO:0003674 | MF | molecular_function | Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. |
TMEM129, TMEM120B, ILVBL, SBNO1, MATN2, DSCR3, KHNYN, CTDSPL, DENR, C21orf2, ORC5, ZNF862, NUPR1, HIST1H2BK, ARL6IP5, ZFAND5, SEC24D, HAUS5, AP2A2, NXPH3, SFT2D2, LRG1, A1BG, PRB1, COL5A2, TPM3, CLTA, NUDT7, HIST1H2AG, ZNF688, TPR, TMEM11, HIST1H2AD, MST1, G0S2, PBLD, TM4SF1, MPV17, IFI27, NPTX2, SLC6A8, NES, MEOX1, LRBA, PTTG1IP, CRISP3, TMEM50B, HIST1H2BD, ROMO1, RAB4B, HIST1H2BC, SNRPN, DLK1, MRPS10, SERF2, ZXDB, ZNF200, REEP5, LMNB2, ICA1, DMWD, ELP6, MN1, IFRD2, NPRL3, MLLT11, SCGB2A2, GPM6B, MAMLD1, FHL1, DGCR6, TRIM14, FAM53B, POLA2, TMEM187, LPIN1, NOMO1, ADIRF, FAM189A2, ZNF77, CSRP2, CARTPT, TMEM132A, QRICH1, FILIP1L, ARID4B, LRRC23, TMEM35, ACSM3, ANKRD39, BOLA3, TMEM128, SLC25A30, EYS, KIAA1217, IDNK, ACBD5, RSPH4A, NDUFAF5, ANKRD45, STRIP1, CDKAL1, ANKRD40, HIST2H2AA3, ZFAND6, ADNP2, TTC27, INO80C, BLOC1S3, WDR74, POTEE, SBSN, C5orf46, TMEM107, TMEM108, HSDL2, TMEM91, FAM65A, LHFPL2, PTCHD4, H2AFV, KNDC1, BTN2A1, HAUS6, KDELC2, CENPV, THNSL2, TDRP, CARKD, SLC35F2, ZC3H3, THNSL1, BEST3, TMEM256, TMEM132C, ZADH2, OXR1, TMEM57, ZNF655, ABTB2, FAM184A, PDDC1, SLC43A3, GSTCD, ABHD11, BPIFB1, SCFD2, CHAC2, CHCHD10, SUSD6, DCUN1D4, LPGAT1, N4BP2L2, HIST1H2AC, TMEM106A, KIAA1191, PTER, DOCK10, HAUS1, DTD2, ZNF486, CYYR1, L3MBTL3, ZNF75A, ZFP3, PTCHD1, KLHL5, CSRNP1, MYADM, CDCA3, PKP2, TMEM47, TMEM121, H2AFJ, HGH1, TUBB6, C9orf16, TIMM21, TMEM106C, C1QTNF3, TMEM120A, FSD1L, RTFDC1, TRIM34, NUF2, ASPSCR1, UACA, GPR63, FAM129A, UBXN6, TM6SF1, TRIM6, ZC3H12C, KLHL4, C20orf27, C6orf62, SPATC1L, CYSTM1, ADAMTS10, TMEM245, CRISPLD1, GHITM, C11orf1, FAM96A, HAUS4, SEC61A2, C17orf75, FANCE, POPDC2, POPDC3, EML4, WFDC1, TMEM8A, EPB41L4A, CD248, MRPL47, IFT46, MXRA5, SMCO4, TM7SF3, BRWD1, TMEM106B, SDAD1, HAUS2, TMEM51, C1orf123, DONSON, MIS18A, GTSE1, FMN2, SEPN1, EMC3, TMEM9, IMPACT, STOML1, HECA, ARPP21, CFDP1, EPHA6, FETUB, TMEFF2, GGA1, C14orf1, CCPG1, NDRG4, NDRG2, TRIM35, DIP2C, KIAA0430, GPSM3, AIM1, AMMECR1, CEP83, RAI2 |
GO:0003676 | MF | nucleic acid binding | Interacting selectively and non-covalently with any nucleic acid. |
ERI2, ENPP3, ZNF862, RNASE1, ZNF853, RNASE2, SON, ENPP1, RNASE4, USP6, POLR2I, ZXDB, ENPP2, GTF2H2, KRBOX4, THOC7, ZNF585A, ZNF880, CBLL1, ZNF720, JAZF1, CHD1L, REXO1, METTL4, ZNF843, SREK1IP1, DBF4B, OSR1, ZCCHC10, ENOX1, HELQ, N6AMT2, SNRNP27, ZCCHC14, DPF3, R3HDM4, ZNF503, CHAMP1, ZFP91, TTC14, RBM15, SPEN, TREX2, SCAPER, ZCCHC2, PEG3, EHD4, SMARCAD1, RAVER2, PRDM6, METTL5, GPATCH2, RBAK, EHD3, ZNRD1, ARPP21, DBF4, TBK1, PNMA3, CIZ1, EXOG, POLR3K, REXO2, R3HCC1, SAMHD1, N6AMT1 |
GO:0003677 | MF | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
ZNF320, EME2, ZNF233, ZNF785, STRA13, AHRR, CENPBD1, ZNF879, NACA, ARNTL, NR5A2, ZNF593, DDX3X, NFIB, ARID1A, CHD1, CHD2, PDCD5, IRF6, TFEC, HNRNPDL, BTAF1, ZNF646, ZBTB5, POLR1C, PLSCR1, SMAD9, SOX12, FOXP2, ZBTB24, PAX4, RAD51C, FOXO3, ZNF207, SOX15, SMARCA5, ZEB2, NUPR1, HBP1, CCNT1, REV3L, HIST1H2BK, PQBP1, ZNF623, DNAJB6, H2AFY, TADA2A, SUPT3H, BANF1, WDHD1, TCEA3, RAD51D, ZNF189, KLF7, ZFAND5, TOX4, TOX, FSBP, ZFPL1, LUC7L3, KIF4A, ZBTB7A, POLR1A, YEATS4, ZMYM6, AIFM1, MBD3, SERPINA3, MYC, ALB, ANG, MYCN, TP53, APP, JUN, RB1, PGR, ENO1, NPM1, PARP1, POLA1, HIST1H2AG, ZNF688, AR, IRF1, TOP1, TOP2A, VDR, ESRRA, PC, XRCC5, GTF2F2, ETS1, ETS2, ZNF44, ZNF250, HIVEP1, TCF4, RAG1, TCF3, H2AFX, ZNF823, ZFX, ZNF12, ZNF14, ZNF17, ZNF19, ZNF20, ZNF182, ZNF22, ZNF23, ZNF24, ZNF25, ZNF43, HMGA1, JUNB, CEBPB, XBP1, ERCC2, RPL7, EGR1, SON, ATF4, LIG1, POLR2E, HIST1H2AD, BCL3, TNFAIP3, NME2, NR4A1, SP100, POLR2A, MCM3, NFYB, YY1, DNMT1, HMGB2, ZFP36, CALR, POLD1, SMARCA1, MAPK1, KDM5A, EEF1D, POLR2B, HIVEP2, HIST1H2BB, MCM7, GTF2F1, RORA, FUS, DDIT3, DEK, SOX6, ZNF93, AHR, SREBF1, PPARG, BRCA1, FEN1, PBX1, STAT3, RFC3, ETV5, MNDA, TMPO, TMPO, STAT5A, RPS27, MSH2, NR4A2, GATA4, NKX2-1, MKI67, RECQL, ATRX, ZFP36L2, RFX2, RFX5, PRIM2, MCM2, NUP153, MRE11A, MXI1, ASCL1, ZNF83, ZNF84, DNA2, NR0B1, HDGF, POLR2J, AGFG1, STAT2, GTF2A1, ZNF133, ZNF136, ZNF140, RBM5, HMGA2, FOSB, CEBPG, POLR2K, RCAN1, POLG, ATXN1, TERF1, PMS1, NR1H2, MLLT10, FOXG1, POLE2, SOX8, KLF3, PCBP4, FOXL2, HIST1H2BD, ZNF445, HIST1H4A, HIST1H2BC, POLR2L, YBX1, RBM6, GTF2I, NUCB2, SIM1, TMF1, SARNP, FOXO4, HNRNPU, E2F1, SET, DR1, POU5F1, BNC1, NUCB1, CREM, PPARD, CENPC, CEBPZ, ZNF85, RELA, EGR4, ZNF91, ZBTB16, APLP2, GABPA, PAX8, ZNF33A, EGR3, ZFP36L1, KHDRBS1, POLE, PPARA, SOS1, SOS2, SSRP1, ZNF844, ZNF616, EP300, ZNF763, FAAP100, ZNF816, TFCP2, TCF15, TRIM26, ILF2, ILF3, FOXC1, PRDM2, ZBTB17, NR1H3, TRIM28, G3BP1, ORC1, IKZF1, NFATC2, SMAD4, NACA, KLF9, C1D, CBFB, NFYC, VEZF1, POLA2, TFDP1, SIM2, ZMYM3, E2F2, HES1, MXD4, ZNF345, ZNF268, ZNF846, KIF22, CHD4, ARID5B, MTF1, DRAP1, SHPRH, ANKRD1, PUM3, NR0B2, TEAD4, TEAD2, TAF1A, TSN, SMAD2, EZH2, ZNF77, ZNF124, PDCD2, TAF12, CRY1, HLF, NFIL3, HIST2H2BE, ZNF423, ZNF630, ERCC6L, QRICH1, LRRFIP1, ZNF791, CHD9, GON4L, ZNF568, ZNF404, GLYR1, ZFP69, ZBED5, FLYWCH1, SMUG1, ZNF326, CENPW, ZNF789, ZMAT1, ZNF766, ZNF667, ZBTB41, ZNF684, ZNF648, ZNF618, ERCC6L2, SPTY2D1, ZNF776, ZNF57, ZNF518A, ZNF787, HIST2H2AA3, ZFAND6, OTUD7B, ADNP2, ZNF280D, TIGD7, MIS18BP1, ZNF529, NFRKB, CERS6, BNC2, ZNF600, ZNF621, TSHZ1, H2AFV, SSH2, ZNF534, ASXL2, SUPT6H, ZNF765, ZNF771, BEND5, EPM2AIP1, HIST3H2A, ZNF627, ZNF367, SETX, ZNF550, MIER3, DENND4A, HUWE1, ZNF467, PEG10, TADA2B, PBRM1, CASZ1, SPATA24, GPBP1, ZNF677, ZNF573, ZNF280B, NOSTRIN, MGA, BAP18, ZC3H3, SRRM1, SUPV3L1, FANCM, ZNF440, ZBED8, ZNF101, XRN1, ZNF654, ZFP82, APITD1, PHTF2, LCORL, ZNF808, ZNF276, CERS5, ZNF655, ZNF283, ZNF513, ZNF615, KIAA1958, ZNF709, ZNF557, ZNF565, BANP, ZNF610, THAP8, ZNF579, ZNF511, HJURP, ZNF485, ZBTB34, MSANTD4, PAPD5, ZNF248, PHC3, GLIS3, ZNF555, KMT2C, ARID1B, ZFP28, CTCFL, ZNF420, THAP6, ZSCAN18, ZNF596, ZNF507, ZNF675, SSH3, ZNF721, ZNF526, ZNF384, THAP3, GTF3C2, NAT14, RNF141, ZFPM2, ZNF606, BBX, KAT6B, AHCTF1, H1FX, TOPBP1, NR4A3, GTF3A, RAD54L, ESR2, PROX1, KAT6A, TAF15, RAD50, KHSRP, SNAPC3, HIST1H2AC, HIST1H2BH, ZNF566, EME1, ZNF669, ZNF689, ZBTB10, ZNF764, ZNF625, ZNF845, ZBED3, HIC2, ZNF333, ZNF462, LCOR, ZBTB45, ZNF521, DNAJC1, SCYL1, ZNF512B, ZFR, ZNF75A, ZNF578, ZNF641, ZMAT2, ZNF285, ZFP3, TOX2, ZNF317, UHRF2, PPP1R10, ZNF300, CIC, ZNF347, STRBP, ZNF607, ZNF587, SPEN, SETDB2, CDC5L, TEAD3, KLF6, NPAS2, EPAS1, HOPX, TCF25, ZNF559, AIFM2, ZNF2, IER2, H2AFJ, ZNF692, POLR3C, ZNF426, PHF20, TIPIN, REPIN1, NUSAP1, HELZ2, ZNF518B, ZNF436, ZNF407, POLR2J2, POLR1E, ZNF350, ZNF700, THAP2, DNTTIP1, CDT1, BLZF1, PNN, SMARCAD1, TAF1D, ZNF395, ZFAND3, LIN28A, CERS4, SAP30L, SP110, RC3H2, PATZ1, ZNF287, GPBP1L1, ZBTB20, HES4, ZNF160, CHD8, TCF7L1, ZNF334, HMG20A, MYNN, PRDM10, ZNF71, ZNF302, POLE4, ASH1L, SLC2A4RG, TSHZ2, POLE3, CHRAC1, KIF15, PDS5B, ZFP64, FANCI, ZNF358, POLR3B, PARPBP, SPHK1, ABI2, BCLAF1, ZNF226, EHF, ZNF224, ZKSCAN7, HMG20B, MYEF2, PSMC3IP, PPARGC1A, ASH2L, ZMYM2, KDM5B, PARP2, TCF20, HMGXB4, MLX, DDX20, NUFIP1, PUF60, DACH1, ZNF230, MUTYH, RABGEF1, ZMYM5, MCM8, ZFP69B, ZNF112, PURG, ZNF222, ZNF580, GTF3C4, ZHX1, ZNF236, TCFL5, MYT1L, PLAGL1, KMT2B, PHTF1, SCML1, GTF2A1L, TTF2, TRIM33, PA2G4, EXO1, SCML2, PIN4, LZTS1, RNF6, MYRF, KDM2A, HIF3A, POLR1D, POLDIP2, LEMD3, CARHSP1, ZNF337, RABGAP1, ZNF175, MTF2, JRKL, CSDC2, NCOR2, RAD54B, LHFP |
GO:0003678 | MF | DNA helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. |
FSBP, MCM3, MCM5, RECQL, ATRX, MCM2, DNA2, SETX, SUPV3L1, FBXO18, CHD8, RUVBL2, RUVBL1, RAD54B |
GO:0003680 | MF | AT DNA binding | Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA). |
HMGA1, HMGA2, MEF2C, HNRNPD |
GO:0003682 | MF | chromatin binding | Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
APBB1, SUPT5H, MEIS1, NR5A2, HDAC3, TOX3, SMAD6, SNAI2, RAD21, SOX15, KDM1A, NUPR1, CCNT1, CCNT2, BRD4, SIN3B, POLQ, TADA2A, RNF8, URI1, TRIM37, CBX7, ACTL6A, WHSC1, EGFR, FOS, ESR1, TP53, MPO, JUN, PRKCB, CDK1, CENPB, POLA1, GLI2, GLI3, AR, EGR2, TOP1, TOP2A, PCNA, TPR, SKI, SKIL, FOSL2, HMGA1, TAL1, CEBPB, RCC1, ELK1, NFKB1, SFPQ, BRD2, POLD1, HOXD10, POLR2B, GTF2H1, CKS2, MCM5, DEK, SREBF1, NUP62, PPARG, ZEB1, RBMX, PBX2, MLH1, BCL6, NCAPD3, GATA4, CBX5, ATRX, YAP1, SOX9, CENPA, CENPF, MEOX1, LHX2, ASCL1, SMARCA2, STAT5B, MSH6, POLG, PRKAA2, HDAC4, CTBP2, YBX1, CBX1, TFAM, RELB, SATB1, MEF2A, SP3, HHEX, RELA, SSBP1, REL, MEF2C, GABPA, RING1, RAD51, FMR1, DLX2, POLE, SSRP1, EP300, FOXO1, CHAF1A, CHAF1B, TRIM28, MTA1, ORC1, NFATC2, SMAD4, RUNX2, HNRNPD, SMC1A, KIAA0101, NCAPD2, BRD3, NONO, ZMYND11, NCOA2, NCOA1, SMAD2, EZH2, PKN1, MSL1, NIPBL, ATAD2, SLC30A9, SMARCD3, TSHZ1, DHX30, TADA2B, PBRM1, SIRT2, FANCM, APITD1, NKAP, SETD7, HDAC7, JDP2, BAP1, HDAC2, CREBBP, EZH1, KAT2B, GATA6, MED12, CREB3L1, MBD6, CDCA5, ZNF274, SMARCD1, AJUBA, PRMT6, IFT74, PRIMPOL, PHF12, CIC, GPER1, MNT, MEIS3, ARID3A, CITED1, CITED2, PYGO2, WAC, NUCKS1, EBF2, PATZ1, CHD8, ENY2, UBE2T, ASH1L, TSHZ2, MBD5, CHD7, RERE, DNMT3B, UXT, MORF4L1, LRWD1, MLH3, TRPS1, BAZ1B, NAP1L2, EXO1, SMC3, HDAC5, ASF1A, NOC2L, L3MBTL1, LOXL2 |
GO:0003684 | MF | damaged DNA binding | Interacting selectively and non-covalently with damaged DNA. |
FANCG, RAD1, NBN, POLQ, TP53, ERCC1, HMGB1, PCNA, XRCC5, UNG, H2AFX, MSH3, XPA, HMGB2, POLD1, MPG, RPA3, BRCA1, FEN1, RAD23A, RAD23B, XPC, EP300, TDG, CUL4B, NEIL3, CREBBP, ERCC4, DCLRE1C, RAD18, POLK, POLI, POLH |
GO:0003688 | MF | DNA replication origin binding | Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
ORC5, HSPD1, MCM5, MCM2, MCM10, ORC3, ORC6 |
GO:0003689 | MF | DNA clamp loader activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. |
RFC4, RFC2, RFC5, RFC3, CHTF18, DSCC1 |
GO:0003690 | MF | double-stranded DNA binding | Interacting selectively and non-covalently with double-stranded DNA. |
STRA13, HMGB3, RAD51C, RAD51D, EGFR, TP53, HMGB1, XRCC5, HMGB2, RBMS1, CTNNB1, FEN1, MSH2, MRE11A, AFF3, MSH6, YBX1, PRKDC, NTHL1, SATB1, RAD51, TARDBP, TDG, ZNF638, SMAD2, CRY1, HLF, IFI16, APITD1, LSM14A, FBXO18, NEIL3, GTF2H4, RAD51AP1, MTERF1, MND1, NUCKS1, TDP1, SLTM, HES2 |
GO:0003691 | MF | double-stranded telomeric DNA binding | Interacting selectively and non-covalently with double-stranded telomere-associated DNA. |
XRCC5, TERF1, PURA, RAD50 |
GO:0003696 | MF | satellite DNA binding | Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA. |
MBD4, CENPB, MLH3 |
GO:0003697 | MF | single-stranded DNA binding | Interacting selectively and non-covalently with single-stranded DNA. |
POLR2D, RAD51C, RAD51D, TDP2, ANXA1, ERCC1, HMGB1, HNRNPA1, HSPD1, NME1, MSH3, HMGB2, RBMS1, MCM4, MCM7, RPA3, MLH1, LRPPRC, MSH2, BRCA2, SUB1, BLM, PMS1, RAD23A, RAD23B, POLR2G, YBX1, SSBP2, PURA, XPC, SSBP1, RAD51, MCM6, PCBP1, TSN, MCM10, NUP35, FBXO18, NEIL3, RTF1, ERCC4, FUBP1, NABP1, RAD51AP1, PURB, PEO1, NABP2, SSBP4, SSBP3, OBFC1, TDP1, MLH3 |
GO:0003700 | MF | transcription factor activity, sequence-specific DNA binding | Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
E2F8, ZNF320, ZNF879, FOXN3, NR5A2, BHLHE40, ZNF213, BACH1, IRF6, TFEC, BTAF1, SMAD7, SMAD9, FOXP2, MAFG, ZSCAN9, HOXA3, CBFA2T2, KLF4, FOXO3, SMAD6, ZNF207, SOX15, PARK2, KDM1A, CREBL2, GAS7, ZNF623, TSC22D2, ZNF217, TADA2A, TADA3, CAPN15, ZNF189, KLF7, NFAT5, ZNF205, ZRANB2, YEATS4, NFATC1, PTTG1, ZBED1, FOS, MYC, ESR1, NR3C1, MYCN, TP53, JUN, RB1, ZFY, NFIC, HOXC4, HMGB1, GLI2, GLI3, MYBL2, AR, NR2F1, THRA, EGR2, VDR, POU2F1, ETS1, ETS2, FOSL1, FOSL2, VAV1, ZNF250, TCF4, TCF3, CREB1, ZFX, ZNF12, ZNF19, ZNF182, ZNF23, ZNF24, ZKSCAN1, ZNF43, HMGA1, TAL1, ATF7, CEBPB, XBP1, EGR1, ATF1, ATF3, ATF4, ATF6, ELK1, TFEB, WT1, NFKB1, BCL3, HNF1A, NME2, NR2F2, NFYB, YY1, HMGB2, ARNT, HOXD10, MZF1, RXRB, KDM5A, HOXA6, HIVEP2, FOXN2, CTNNB1, RORA, DDIT3, SOX6, ZNF93, AHR, SREBF1, PPARG, ZEB1, PBX1, PBX2, STAT3, ID1, ETV5, BCL6, WNT5A, BUD31, ELK3, STAT5A, GATA4, NKX2-1, NOTCH1, ZFP36L2, RFX2, RFX5, SOX9, MEOX1, ETV1, ASCL1, ZNF83, STAT5B, STAT2, ZNF133, ZNF140, ZNF138, RCAN1, HIRA, MLLT10, PRDM15, KLF3, FOXL2, ZNF445, LMO4, YBX1, GTF2I, ELF3, SIM1, SMAD3, ZBED6, FOXO4, ZNF200, TFAM, HSF1, IRF9, E2F1, INSM1, RELB, POU5F1, BNC1, MEF2A, ID3, CREB5, POU3F1, CREM, PPARD, ZNF85, ZNF117, ZNF92, RELA, REL, MXD1, EGR4, ZNF91, MEF2C, GABPA, PAX8, ZNF33A, EGR3, SOX4, ZFP36L1, DLX2, PPARA, ZNF616, ZNF816, TFCP2, TCF15, FOXC1, TAF10, PRDM2, ZBTB17, KLF10, TARDBP, TRIM28, MTA1, ZNF211, IKZF1, NFATC2, SMAD4, HDAC1, RUNX3, KLF9, GTF2H2, RUNX2, CBFB, NFYC, TFDP1, SIM2, E2F2, TRIM25, HES1, NFE2L1, ZNF345, ZNF268, MEF2D, POU6F1, MTF1, DRAP1, TCEAL1, TAF5, TEAD4, TEAD2, TSC22D1, SMAD2, SMAD1, USF2, ZFHX3, ZIC1, TAF12, NFIL3, HIF1A, ZSCAN26, ZNF630, ZSCAN23, ZNF568, TAF1B, ZNF789, HIVEP3, ZNF658, PLAG1, ZNF585A, ZNF449, ZNF880, SLC30A9, ZNF600, ZNF621, ZNF534, SUPT6H, ZNF367, ZSCAN2, TADA2B, ZSCAN30, GPBP1, ZNF677, ZNF573, GATAD2A, CREBRF, AEBP1, MGA, TRIM22, ZFP82, ZNF567, ZNF808, ZNF655, ZNF283, ZNF615, ZNF565, ZBTB38, ZNF548, ZNF397, ZFP28, ZNF420, ZNF564, GATAD1, GLMP, ZNF606, ARNTL2, CSRNP3, AHCTF1, ESR2, GTF2H4, PROX1, CREBBP, GATA6, FUBP1, ZBED6CL, ZNF274, ZNF419, HES6, ZSCAN31, ZFP3, ZNF317, ZNF300, NR1H4, CSRNP1, ZNF607, ATOH8, ZNF382, UHRF1, TCF12, TSC22D3, MNT, TEAD3, PITX2, SMAD5, HNRNPAB, NPAS2, CITED1, CITED2, TCF25, ZNF2, SALL3, BACH2, FOXP3, ZNF436, CSRNP2, BLZF1, IKZF4, IKZF5, ZNF552, ZNF287, GPBP1L1, ZNF532, TCF7L1, ZNF334, HMG20A, MYNN, HEYL, TCF7L2, ZNF71, ZNF302, SLC2A4RG, TULP4, ZNF586, AATF, ZNF226, EHF, ZNF224, ZKSCAN7, ZNFX1, RCOR3, RERE, KDM5B, TCF20, MLX, AFF4, TRPS1, ZNF639, CNOT7, ZFP69B, ZNF112, NOCT, ZHX1, TCFL5, MYT1L, KMT2B, PHTF1, SCML1, PA2G4, SCML2, TCF19, LZTS1, MYRF, TSC22D4, L3MBTL1, ZNF175, NFE2L3, ZNF451, HEY1, KLF2 |
GO:0003705 | MF | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. |
MEIS1, NR5A2, BHLHE40, SNAI2, NFATC1, PTH, JUN, CREB1, CEBPB, ATF1, ARNT, NKX2-1, SOX9, PURA, MEF2A, RELA, FOXC1, TEAD2, USF2, ZFHX3, HIF1A, PROX1, GATA6, NR1H4, FOXP3, SOX17 |
GO:0003707 | MF | steroid hormone receptor activity | Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. |
NR5A2, PGRMC2, ESR1, PGR, NR2F1, THRA, VDR, ESRRA, NR1D1, NR4A1, NR2F2, RXRB, RORA, PPARG, NR4A2, NR0B1, NR1H2, PPARD, PPARA, NR1H3, NR1D2, NR0B2, PAQR8, NR4A3, ESR2, NR1H4, OR51E2, PAQR5 |
GO:0003712 | MF | transcription cofactor activity | Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. |
LDB2, MED14, LPXN, TADA2A, MUC1, CREB1, BTG1, TMF1, NRG1, MXD1, ZNF763, NMI, CBFB, NFE2L1, ZMYND11, TRIP13, ZNF667, KAT2B, MED12, MED30, HES6, NFKBIZ, MED4, MED17, THRAP3, MED16, TRRAP |
GO:0003713 | MF | transcription coactivator activity | Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
PDLIM1, AIP, ARID1A, TFEC, TGFB1I1, MED7, MED14, PQBP1, EDF1, TADA2A, SUPT3H, TADA3, MED6, KLF7, SUPT7L, BCL10, ACTL6A, JUN, RB1, NPM1, NR2F1, JUP, TCF3, ZFX, JUNB, JUND, DDX5, PSMC3, ATF6, MAK, SP100, YY1, ARNT, RXRB, KDM5A, CTNNB1, GTF2F1, FUS, ZEB1, BRCA1, GATA4, YAP1, NRIP1, CDK7, SMARCA2, SMARCA4, GTF2A1, GTF2A2, SUB1, CTBP2, ELF3, PPARD, GABPA, EP300, TAF10, NR1H3, MTA1, MED21, NCOA4, CBFB, NFYC, TFDP1, NPAT, LPIN1, ARID5B, MTF1, NFATC4, TAF11, NCOA2, TRIP11, NCOA1, SMARCD3, TADA2B, MTDH, CARM1, WWC1, CCAR1, YAF2, KMT2E, MAML2, JMY, ARID1B, SMARCC2, ESR2, CREBBP, KAT6A, KAT2B, DDX17, SMARCC1, RBPMS, MED12, TADA1, SMARCD1, MAML3, NR1H4, CITED4, MYCBP, MNT, CITED1, CITED2, HTATIP2, SOX17, MED20, SRA1, ENY2, BRD7, MED17, PPARGC1A, RNF14, TCF20, MKL2, GTF2A1L, USP22, THRAP3, MED16, NFE2L3, HCFC2, NCOA3 |
GO:0003714 | MF | transcription corepressor activity | Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. |
E2F8, SAP18, ZNF593, BHLHE40, TFEC, HDAC3, RBFOX2, SIAH2, CBFA2T2, TBL1X, NCOR1, PEX14, GMNN, HSBP1, CREG1, TDP2, SKI, JUNB, PSMC3, ATF3, NR1D1, SP100, NR2F2, YY1, YWHAB, DDIT3, ZEB1, ELK3, YAP1, ID4, NRIP1, MXI1, ERF, SMARCA4, NR0B1, ZNF136, HIRA, ATN1, HDAC4, CTBP2, SRSF2, RELB, DR1, ID3, ZNF85, MXD1, C1QBP, AES, GPS2, TRIM28, MTA1, C1D, TOB2, NPAT, MXD4, DRAP1, ZMYND11, ANKRD1, NR0B2, NFIL3, GON4L, ATF7IP, KCTD1, JAZF1, AEBP1, CCAR1, YAF2, TRIM22, DDX54, PPP1R13L, HDAC7, ZFPM2, PROX1, PBXIP1, ZNF274, TONSL, AJUBA, PAWR, NR1H4, TRIB3, PFDN5, MNT, CITED2, MYBBP1A, TBL1XR1, FOXP3, HIPK2, TAF9B, BRD7, HEYL, KMT5A, RLIM, LMCD1, RCOR3, DNMT3B, KDM5B, LIMD1, HDAC9, ZHX1, SUFU, CDYL, NOC2L, LOXL2, NCOR2, EID1 |
GO:0003720 | MF | telomerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. |
DKC1, TERF1, PTGES3, TEP1 |
GO:0003723 | MF | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
MIF4GD, IGF2BP3, RTCA, NOP56, DDX3X, RNASET2, XPO1, KHNYN, SYNJ2, RBFOX2, CTIF, HNRNPR, SYNJ1, NUDT21, AHCYL1, HBP1, SYNCRIP, DKC1, NOL3, DUSP11, PRPF40A, SRSF10, KHDRBS3, RNASEH2A, RSL1D1, UBR5, ZRANB2, CELF2, POP4, PTBP3, LSM8, NR3C1, NPM1, HNRNPC, SNRPA, CNP, HNRNPA1, TROVE2, HSP90B1, HNRNPL, RPL7, SON, WT1, RPS4Y1, HNRNPA2B1, EIF4B, YY1, PSMA1, DNMT1, RPL13, PTBP1, TARS, RBMS1, HNRNPH3, HNRNPH1, RPL22, FUS, RPL4, SRP14, RBMX, BRCA1, LRPPRC, RPL27A, RPL5, RPL21, RPL28, RPS5, RPL29, RPL34, SRP9, SARS, RANBP2, RPL14, PAPOLA, FXR1, NOVA1, NR0B1, HNRNPA3, HNRNPM, AGFG1, RBM5, MRPL12, HNRNPH2, PCBP4, RPS3A, RPL26, RPL15, RPL37, RPS7, RPS15A, RPS16, RPS14, SNRPF, LSM3, LSM6, SNRPD1, RPL7A, RPS25, RPL30, RPL31, RPL10A, RPL11, RPL41, SNRPN, RPL38, EIF5A, YBX1, RBM6, RPP30, RAE1, RPL24, RPL19, RBM3, HNRNPU, EWSR1, RPL18A, RNASEL, EXOSC9, FMR1, RPL18, KHDRBS1, SRSF1, NCBP1, GRSF1, SF3A3, ILF3, CSTF3, TARDBP, SRSF6, IFIT5, C1D, HNRNPD, MORC3, FASTK, CAPRIN1, PUM1, ZNF638, SUZ12, EXOSC7, PCBP1, RBMS2, ELAVL1, MRPL23, TIMM50, PABPC1L, PDCD4, ZNF385B, NOM1, ZMAT1, DDX60L, EARS2, RBM48, THOC7, MRM1, JMJD6, RBM43, PARS2, NUFIP2, PABPN1, PPARGC1B, DCP2, RBM45, ZC3H3, SUPV3L1, ARHGEF28, AGGF1, CPEB3, PUM2, ZCRB1, TRUB1, NANOS1, GTF3A, AKAP1, DDX17, EMG1, RBPMS, NABP1, RAD51AP1, RPL39L, DAZAP1, NAF1, RBM17, THOC3, YTHDC1, ZMAT2, BARD1, HNRNPAB, TEP1, LARP6, HNRNPUL1, RBM4, PAPOLG, MRPL4, MRPL1, NIFK, PUS3, CRNKL1, PAIP1, UPF3A, PHAX, LIN28A, UPF2, APOBEC3G, CWC22, TNRC6C, EXOSC3, MBNL1, RBFOX1, CDKN2AIP, DDX43, CWC15, CPSF2, PPARGC1A, NUFIP1, CNOT7, LSM7, CNOT6, PPIE, NOVA2, SCAF8, DIS3, RCL1, LSM2, RBMX2, SAMHD1, KIAA0430, LSM5, CSDC2, RBM8A |
GO:0003724 | MF | RNA helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. |
DHX15, DHX16, FSBP, DDX5, SKIV2L2, DDX17, DDX24, RAD54B |
GO:0003725 | MF | double-stranded RNA binding | Interacting selectively and non-covalently with double-stranded RNA. |
TLR3, DHX15, PRKRA, STAU1, TFRC, SLC3A2, HSP90AB1, VIM, HSPD1, ACTN1, EIF4A1, TUBA1B, TUBB4B, ILF2, ILF3, RFTN1, ELAVL1, LRRFIP1, DHX30, MTDH, SUPV3L1, LSM14A, STRBP, DHX36, MRPL44, AGO4, MBNL1, STAU2, AGO2, DICER1, MYH4 |
GO:0003726 | MF | double-stranded RNA adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule. |
ADARB1 |
GO:0003727 | MF | single-stranded RNA binding | Interacting selectively and non-covalently with single-stranded RNA. |
POLR2D, CBX7, ANXA1, SNRPC, HNRNPA1, ZFP36, POLR2G, DLX2, IFIT5, LACTB2, JMJD6, LSM14A, STRBP, AGO4, NXF1, AGO2 |
GO:0003729 | MF | mRNA binding | Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
RBFOX2, NUDT21, DXO, LUC7L3, DHFR, TYMS, SSB, HSP90AA1, SNRPC, TPR, RPS2, RPL7, ZFP36, CALR, RBMX, RPL13A, RPL35, RPS5, RBM25, FXR1, NOVA1, HNRNPA3, RBM5, EIF4A1, RPS13, RPS26, TRA2B, ADARB1, FMR1, C1QBP, ZFP36L1, SRSF1, GRSF1, CSTF3, G3BP1, EIF3A, SLBP, PCBP1, PUM3, TSN, ELAVL1, SNRNP35, NCBP3, SAMD4B, RBPMS2, THOC2, UHMK1, NUDT16, EDC3, QKI, PURB, HNRNPAB, PAIP2, RBM4, RBM38, ESRP2, RC3H2, METTL14, LUC7L, EIF4ENIF1, RBFOX1, NXF1, NOCT, PTBP2, AGO2, G3BP2, SAMD4A, LUC7L2, RBM8A |
GO:0003730 | MF | mRNA 3'-UTR binding | Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. |
IGF2BP3, HNRNPR, PARN, HNRNPC, HNRNPA2B1, ZFP36, ZFP36L2, FXR1, PCBP4, FMR1, ZFP36L1, CRYZ, TARDBP, AUH, CIRBP, PUM1, RNPS1, ELAVL1, CPEB4, LARP1, CPEB2, SERBP1, CPEB3, PUM2, SECISBP2L, SECISBP2, RBM4, RBM24, CARHSP1, IGF2BP2 |
GO:0003735 | MF | structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
MRPS12, SLC25A17, MRPS14, MRPL33, SLC25A12, NDUFA7, SLC25A14, SLC25A5, RPLP1, RPLP2, RPLP0, RPS17, RPSA, SLC25A4, RPS2, SLC25A16, RPL35A, RPL7, RPL17, RPS4Y1, UCP1, RPL13, RPL10, RPL12, RPL22, RPL4, RPL13A, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, RPL29, RPL34, MRPL19, RPL14, DAP3, MRPL12, SLC25A1, UCP2, UCP3, RPS20, RPS3A, RPL26, RPL15, RPL27, RPL37A, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, UBA52, RPL38, RPS21, MRPS25, MRPS5, MRPS36, MRPS21, MRPS34, RPL24, RPL36A, RPL19, SLC25A3, RPL18A, RPL18, MRPL23, MRPL51, SLC25A30, MRPL14, RPL22L1, SLC25A26, RPS27L, MRPL21, MRPL55, MRPL52, MRPL41, MRPL30, SLC25A43, MRPS31, RPL36AL, SLC25A36, RPL39L, SLC25A44, MRPL34, MRPL57, SLC25A23, MRPL32, MRPL4, MRPL1, MRPL37, SLC25A39, SLC25A18, SLC25A19, MRPL47, MRPL17, MRPS18A, MRPL16, SLC25A37, MRPL35, MRPL15, MRPL36, SLC25A10, SLC25A13, MRPS2, RPL36, SLC25A15, MRPS18B, MRPL42 |
GO:0003743 | MF | translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
EIF4G3, DENR, EIF4E2, EIF1B, EIF5B, EIF3J, EIF2S1, EIF4E, EIF4B, EIF2S3, EIF1, EIF1AX, EIF5, EIF3B, EIF6, EIF4A1, EIF2B5, EIF3A, EIF2B1, EIF4A2, DHX29, EIF1AD, MTIF3, EIF2B3, EIF3K, EIF2B4, AGO2 |
GO:0003746 | MF | translation elongation factor activity | Functions in chain elongation during polypeptide synthesis at the ribosome. |
EEF1E1, EEF2, EEF1B2, EEF1D, TSFM, EIF5A, EEF1A1, EEF1A2, GFM1, EIF5A2, HBS1L |
GO:0003747 | MF | translation release factor activity | Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. |
GSPT1 |
GO:0003755 | MF | peptidyl-prolyl cis-trans isomerase activity | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
PPIH, PPIB, FKBP2, PPIF, NKTR, PPIC, RANBP2, PPIA, FKBP3, FKBP4, PPID, PPIL2, PPIG, FKBP5, PPP2R4, CWC27, PPIL4, FKBP10, FKBP14, FKBP11, PPIE, PIN4, FKBP7 |
GO:0003756 | MF | protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
ITGB3, P4HB, PDIA4, PDIA3, PDIA5, PDIA6, TXNDC11, QSOX2, ERO1B, PIGK, ERO1A, ERP44, TMX4, GLRX2 |
GO:0003774 | MF | motor activity | Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. |
MYO1G, DYNC1I1, KIF1C, MYL6B, MYH9, MYH11, MYL6, DYNLL1, DYNLT1, MYO1E, DCTN2, DCTN1, KIF18B, DYNC2LI1, MYO10, KIF15, DNAH9, DNAI1, MYO6 |
GO:0003777 | MF | microtubule motor activity | Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). |
DYNC1I1, DNALI1, DYNC1LI2, KIF1C, KIF5C, KIF1B, KIF20A, KIF4A, DNAL4, KIF11, CENPE, KIF23, DNAH14, DYNC1I2, DYNC1H1, KIF22, KIF14, KLC3, DNAH12, DNAH10, DNAH5, APPBP2, DNAH11, KIF2C, KIFC1, KIF13B, KIF15, DNAH9, DNAH1, STARD9, SMC3 |
GO:0003779 | MF | actin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
WASH1, MYO1G, MYO1C, HIP1, WASL, ABLIM1, ENC1, ACTN4, PARK2, DIAPH2, PHACTR2, FLNB, RP2, MICAL2, ABLIM3, GC, ANG, ALDOA, ITGB1, TPM3, PFN1, TPM2, TPM1, DMD, LCP1, HCLS1, EZR, SYN1, TNNI3, S100A4, TMOD1, LMOD1, CORO1A, GBP1, LSP1, NF2, RDX, MYH9, CAPG, CAPZB, EMD, CNN1, CAPZA1, SMTN, CXCR4, NCALD, TPM4, MYBPC1, SPTBN1, TAGLN, DST, YWHAH, PTK2, CALD1, KCNMA1, EPS8, SNTA1, SNTB2, MYO9B, IQGAP2, SHROOM2, SNTB1, COTL1, DAG1, CNN3, DIXDC1, MYLK, DBN1, FSCN1, CCDC88A, CROCC, MPRIP, SSH2, MAEA, PXK, GAS2L3, PLEKHH2, PHACTR4, ENAH, JMY, MYRIP, KIF18A, FBXO25, MICAL1, SSH3, PALLD, SYNE2, MIB2, MYO19, PDLIM5, PAWR, FGD4, PACRG, KLHL5, FMNL2, TRPM7, MLPH, SORBS1, KLHL4, SPTBN4, EPB41L1, PSTPIP2, TRPV4, TNS1, MYOZ1, ANLN, DIAPH3, PARVA, TBCCD1, FMN2, IMPACT, MYOT, HDAC6, ADD3, KLHL3, BAIAP2L1, EVL, MYH2, MYO5B, MYO6, SYNPO2, MACF1, LIMCH1, TRPC6, STK38L, EPB41L3, DAAM1, MYO5A, FHOD1, MYH4, WASF2 |
GO:0003785 | MF | actin monomer binding | Interacting selectively and non-covalently with monomeric actin, also known as G-actin. |
MTSS1, COBL, PFN1, TMSB15A, MYL4, NOS3, CORO1A, ABL2, TMSB4X, TMSB10, TWF1, COBLL1, TWF2, LIMA1 |
GO:0003796 | MF | lysozyme activity | Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. |
LYZL6, LYZ, LYG2 |
GO:0003810 | MF | protein-glutamine gamma-glutamyltransferase activity | Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. |
F13A1, TGM2, TGM4 |
GO:0003823 | MF | antigen binding | Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. |
IGLL5, TSPAN4, TGFB1, HLA-B, IL7R, HLA-G, LAG3, AZGP1, PPP2R1A, FCN2, MICB, MICA, HFE, MR1, SPON2, ULBP3, ULBP2 |
GO:0003824 | MF | catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
HSD17B6, AZIN1, MGAM, ALDH1L1, DDAH1, DDAH2, SLC3A2, ALAD, HSD17B1, HPGD, SYN1, CAPN3, AADAC, AOAH, GTF2F1, FHIT, ASAH1, ITPK1, PIGH, ESPL1, DIP2A, OLFM4, SPATA20, PIGC, SYN2, ECHDC3, DIP2C, MED16 |
GO:0003826 | MF | alpha-ketoacid dehydrogenase activity | Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid. |
BCKDHA, BCKDHB |
GO:0003828 | MF | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. |
ST8SIA6, ST8SIA4 |
GO:0003831 | MF | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. |
B4GALT5, B4GALT4, B4GALT1, B4GALT6 |
GO:0003835 | MF | beta-galactoside alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. |
ST6GAL1, ST6GAL2 |
GO:0003836 | MF | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R. |
ST3GAL1, ST3GAL3, ST3GAL4, ST3GAL2, ST3GAL6 |
GO:0003839 | MF | gamma-glutamylcyclotransferase activity | Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. |
CHAC2, CHAC1, GGACT |
GO:0003840 | MF | gamma-glutamyltransferase activity | Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. |
GGT7 |
GO:0003841 | MF | 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
GPAT3, LPCAT3, LCLAT1, MBOAT2, LPCAT2, GPAT4, ABHD5, LPGAT1, MBOAT7, AGPAT4, AGPAT3, CRLS1 |
GO:0003844 | MF | 1,4-alpha-glucan branching enzyme activity | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. |
GBE1 |
GO:0003845 | MF | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity | Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+). |
HSD11B1, HSD11B2 |
GO:0003846 | MF | 2-acylglycerol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. |
DGAT2 |
GO:0003847 | MF | 1-alkyl-2-acetylglycerophosphocholine esterase activity | Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. |
PAFAH1B2, PLA2G7, PAFAH1B3 |
GO:0003854 | MF | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+). |
HSD3B1, HSD3B2, NSDHL, HSD3B7 |
GO:0003857 | MF | 3-hydroxyacyl-CoA dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). |
HSD17B4, HADHB, HADH, HSD17B10, CRYL1 |
GO:0003858 | MF | 3-hydroxybutyrate dehydrogenase activity | Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH. |
BDH2 |
GO:0003860 | MF | 3-hydroxyisobutyryl-CoA hydrolase activity | Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. |
HIBCH |
GO:0003863 | MF | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity | Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. |
BCKDHA, BCKDHB |
GO:0003865 | MF | 3-oxo-5-alpha-steroid 4-dehydrogenase activity | Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. |
SRD5A1, SRD5A2 |
GO:0003867 | MF | 4-aminobutyrate transaminase activity | Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. |
ABAT |
GO:0003868 | MF | 4-hydroxyphenylpyruvate dioxygenase activity | Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. |
HPDL |
GO:0003872 | MF | 6-phosphofructokinase activity | Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. |
PFKL |
GO:0003873 | MF | 6-phosphofructo-2-kinase activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). |
PFKFB2, PFKFB1, PFKFB3, PFKFB4 |
GO:0003875 | MF | ADP-ribosylarginine hydrolase activity | Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose. |
ADPRH |
GO:0003876 | MF | AMP deaminase activity | Catalysis of the reaction: AMP + H2O = IMP + NH3. |
AMPD3 |