| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0070698 | MF | type I activin receptor binding | Interacting selectively and non-covalently with a type I activin receptor. |
SMAD6 |
GO:0070699 | MF | type II activin receptor binding | Interacting selectively and non-covalently with a type II activin receptor. |
INHBA, SYNJ2BP, MAGI2 |
GO:0070700 | MF | BMP receptor binding | Interacting selectively and non-covalently with a BMP receptor. |
BMP2, BMP4, BMP3, BMP6, BMP8B, BMP8A, PYCARD |
GO:0070715 | BP | sodium-dependent organic cation transport | The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
SLC22A5 |
GO:0070717 | MF | poly-purine tract binding | Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. |
TRA2B |
GO:0070723 | BP | response to cholesterol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. |
TGFB1, CCL3, TGFBR1, TGFBR2, SMAD2 |
GO:0070724 | CC | BMP receptor complex | A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits. |
BMP2 |
GO:0070728 | MF | leucine binding | Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid. |
GLUD2, SESN2, UBR1, SESN1 |
GO:0070733 | MF | protein adenylyltransferase activity | Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins. |
FICD |
GO:0070734 | BP | histone H3-K27 methylation | The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone. |
EZH2, EZH1, EHMT2 |
GO:0070740 | MF | tubulin-glutamic acid ligase activity | Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule. |
TTLL1 |
GO:0070741 | BP | response to interleukin-6 | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. |
PCK1, CHI3L1, CITED1 |
GO:0070742 | MF | C2H2 zinc finger domain binding | Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. |
WT1, HMGA2, EHMT2, SRRM2 |
GO:0070761 | CC | pre-snoRNP complex | A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes. |
NOP56, NUFIP1 |
GO:0070762 | CC | nuclear pore transmembrane ring | A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex. |
NDC1 |
GO:0070765 | CC | gamma-secretase complex | A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein. |
TMED10, PSEN1, APH1B, APH1A |
GO:0070776 | CC | MOZ/MORF histone acetyltransferase complex | A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. |
KAT6B, KAT6A, MEAF6 |
GO:0070779 | BP | D-aspartate import | The directed movement of D-aspartate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle. |
SLC1A3, SLC1A2 |
GO:0070780 | MF | dihydrosphingosine-1-phosphate phosphatase activity | Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate. |
SGPP2 |
GO:0070813 | BP | hydrogen sulfide metabolic process | The chemical reactions and pathways involving hydrogen sulfide, H2S. |
ETHE1 |
GO:0070814 | BP | hydrogen sulfide biosynthetic process | The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. |
MPST, CTH, CBS |
GO:0070815 | MF | peptidyl-lysine 5-dioxygenase activity | Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2. |
JMJD6 |
GO:0070816 | BP | phosphorylation of RNA polymerase II C-terminal domain | The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. |
GTF2H1, CDK13, GTF2H4, CDK12 |
GO:0070820 | CC | tertiary granule | A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. |
STX7, ADAM8, STXBP2 |
GO:0070821 | CC | tertiary granule membrane | The lipid bilayer surrounding a tertiary granule. |
SLC11A1 |
GO:0070822 | CC | Sin3-type complex | Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. |
BRMS1L, SUDS3 |
GO:0070826 | CC | paraferritin complex | A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme. |
SLC11A2 |
GO:0070827 | BP | chromatin maintenance | The chromatin organization process that preserves chromatin in a stable functional or structural state. |
SUPV3L1 |
GO:0070828 | BP | heterochromatin organization | Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. |
SETD7 |
GO:0070829 | BP | heterochromatin maintenance | The chromatin organization process that preserves heterochromatin in a stable functional or structural state. |
MTHFR |
GO:0070830 | BP | bicellular tight junction assembly | The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. |
CLDN3, ACTN4, CLDN1, APC, PRKCI, DLG1, OCLN, MTDH, MPP5, INADL, PARD3, MARVELD3, TBCD, PARD6B, ECT2, PARD6A, F11R |
GO:0070836 | BP | caveola assembly | The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. |
CAV2, CAV1 |
GO:0070837 | BP | dehydroascorbic acid transport | The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C. |
SLC2A1, SLC2A3 |
GO:0070838 | BP | divalent metal ion transport | The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
SLC41A2 |
GO:0070839 | BP | divalent metal ion export | The directed movement of divalent metal cations, any metal ion with a +2 electric charge, out of a cell or organelle. |
SLC11A1 |
GO:0070840 | MF | dynein complex binding | Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. |
CCDC42B, TPR, HDAC6 |
GO:0070842 | BP | aggresome assembly | The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein. |
UBD, PARK2, TRIM37, VCP, HDAC6 |
GO:0070845 | BP | polyubiquitinated misfolded protein transport | The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. |
HDAC6 |
GO:0070846 | BP | Hsp90 deacetylation | The modification of an Hsp90 protein by removal of acetyl groups. |
HDAC6 |
GO:0070847 | CC | core mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
MED14, MED6, MED4 |
GO:0070848 | BP | response to growth factor | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
MYC, ANXA3, CDC34, LUM, DUSP6, GATA6, HDAC6 |
GO:0070849 | BP | response to epidermal growth factor | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. |
TPR, MAPK3, MAPK1, ASCL1 |
GO:0070851 | MF | growth factor receptor binding | Interacting selectively and non-covalently with a growth factor receptor. |
APP, FYN |
GO:0070852 | CC | cell body fiber | A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches. |
ASS1, PENK, SRD5A1, SRD5A2, KCNJ11, SPTBN4 |
GO:0070856 | MF | myosin VI light chain binding | Interacting selectively and non-covalently with a light chain of a myosin VI complex. |
IQGAP3 |
GO:0070857 | BP | regulation of bile acid biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. |
NR1H4 |
GO:0070858 | BP | negative regulation of bile acid biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. |
FGF19, PROX1, NR1H4 |
GO:0070859 | BP | positive regulation of bile acid biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. |
NR1D1, STAR, STARD4 |
GO:0070860 | CC | RNA polymerase I core factor complex | A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p. |
TAF1B |
GO:0070863 | BP | positive regulation of protein exit from endoplasmic reticulum | Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum. |
SORL1, SEC16B, TMEM30A |
GO:0070873 | BP | regulation of glycogen metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. |
POMC, PHLDA2 |
GO:0070876 | CC | SOSS complex | A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. |
INTS3, NABP1, NABP2, INIP |
GO:0070878 | MF | primary miRNA binding | Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. |
SMAD1, EZH2 |
GO:0070883 | MF | pre-miRNA binding | Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA. |
DICER1 |
GO:0070884 | BP | regulation of calcineurin-NFAT signaling cascade | Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. |
NFAT5, RCAN1 |
GO:0070885 | BP | negative regulation of calcineurin-NFAT signaling cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. |
PRNP, ATP2B4, CHP1 |
GO:0070886 | BP | positive regulation of calcineurin-NFAT signaling cascade | Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade. |
IGF1, ERBB3, NRG1, AKAP6, SPPL3, CIB1, LMCD1 |
GO:0070888 | MF | E-box binding | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
ARNTL, BHLHE40, PER1, TCF21, MYC, TCF4, TCF3, TAL1, LMO2, AHR, ZEB1, ASCL1, SREBF2, TWIST1, ARNTL2, ATOH8, TCF12 |
GO:0070890 | MF | sodium-dependent L-ascorbate transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in). |
SLC23A2 |
GO:0070891 | MF | lipoteichoic acid binding | Interacting selectively and non-covalently with lipoteichoic acid. |
CD14, CD6 |
GO:0070892 | MF | lipoteichoic acid receptor activity | Combining with lipoteichoic acid and transmitting the signal to initiate a change in cell activity. |
CD36 |
GO:0070895 | BP | negative regulation of transposon integration | Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule. |
ZNF93, ZNF91 |
GO:0070901 | BP | mitochondrial tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule. |
TRMT5, HSD17B10 |
GO:0070903 | BP | mitochondrial tRNA thio-modification | The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule. |
TRMU |
GO:0070904 | BP | transepithelial L-ascorbic acid transport | The directed movement of L-ascorbic acid from one side of an epithelium to the other. |
SLC23A2 |
GO:0070905 | MF | serine binding | Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid. |
SHMT1, THNSL2 |
GO:0070911 | BP | global genome nucleotide-excision repair | The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. |
ERCC1, PARP1, UBC, ERCC2, XPA, GTF2H1, RAD23B, SUMO3, SUMO2, RBX1, RPS27A, UBA52, UBE2I, XPC, CUL4A, CUL4B, GTF2H2, UBE2V2, RNF111, USP45, CHD1L, GTF2H4, ERCC4 |
GO:0070914 | BP | UV-damage excision repair | A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). |
ERCC1, XPA, XPC, CUL4B, HIST3H2A |
GO:0070925 | BP | organelle assembly | The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. |
STX7 |
GO:0070926 | BP | regulation of ATP:ADP antiporter activity | Any process that modulates the activity of an ATP:ADP antiporter. |
RIPK1 |
GO:0070932 | BP | histone H3 deacetylation | The modification of histone H3 by the removal of one or more acetyl groups. |
HDAC3, PER1, SFPQ, HDAC4, HDAC1, SIRT2, HDAC7, HDAC2, HDAC8, SMARCAD1, HDAC6, HDAC9, HDAC5 |
GO:0070933 | BP | histone H4 deacetylation | The modification of histone H4 by the removal of one or more acetyl groups. |
HDAC4, HDAC1, SIRT2, HDAC2, SMARCAD1, HDAC9 |
GO:0070934 | BP | CRD-mediated mRNA stabilization | An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). |
SYNCRIP, YBX1, HNRNPU |
GO:0070935 | BP | 3'-UTR-mediated mRNA stabilization | An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. |
HNRNPC, ZFP36, MAPKAPK2, TIRAP, TARDBP, ELAVL1, MAPK14 |
GO:0070936 | BP | protein K48-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. |
TRIM38, UBE2C, PARK2, RNF8, TNFAIP3, CDC34, UBE2A, UBE2E1, TTC3, UBE2D3, UBE2H, UBE2B, SYVN1, HACE1, RNF152, RFFL, UBE2E3, PELI1, ITCH, UBE2E2, NEDD4L, RNF126, UBE2T, RNF146, RNF216, KLHL3, AMFR, RNF6, UBE2D4 |
GO:0070937 | CC | CRD-mediated mRNA stability complex | A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, IGF2BP1 and at least four additional proteins: HNRNPU, SYNCRIP, YBX1, and DHX9. |
SYNCRIP, YBX1, HNRNPU |
GO:0070938 | CC | contractile ring | A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles. |
PRC1, DAG1, KIF20B |
GO:0070940 | BP | dephosphorylation of RNA polymerase II C-terminal domain | The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form. |
RPRD1A, SSU72 |
GO:0070945 | BP | neutrophil mediated killing of gram-negative bacterium | The directed killing of a gram-negative bacterium by a neutrophil. |
TUSC2, TREM1 |
GO:0070963 | BP | positive regulation of neutrophil mediated killing of gram-negative bacterium | Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil. |
F2RL1 |
GO:0070966 | BP | nuclear-transcribed mRNA catabolic process, no-go decay | The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation. |
PELO, CNOT6 |
GO:0070970 | BP | interleukin-2 secretion | The regulated release of interleukin-2 from a cell. |
PNP, GPAM |
GO:0070971 | CC | endoplasmic reticulum exit site | An endoplasmic reticulum part at which COPII-coated vesicles are produced. |
PDCD6, SEC31A, APOB, PDCD6IP, YIPF5, TMED5 |
GO:0070972 | BP | protein localization to endoplasmic reticulum | A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. |
PPP1R15A, ANK2, SEC16B, VAPA |
GO:0070973 | BP | protein localization to endoplasmic reticulum exit site | A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site. |
BCAP31, GBF1 |
GO:0070974 | MF | POU domain binding | Interacting selectively and non-covalently with a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors. |
AR |
GO:0070975 | MF | FHA domain binding | Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich. |
MDC1 |
GO:0070977 | BP | bone maturation | A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. |
GH1 |
GO:0070979 | BP | protein K11-linked ubiquitination | A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. |
UBE2C, PARK2, CDC27, UBE2A, UBE2D3, UBE2H, UBE2B, UBE2S, UBE2E3, UBE2W, UBE2E2, ANAPC1, UBE2T, CDC23, ANAPC5, ANAPC4, FZR1, ANAPC10, UBE2D4 |
GO:0070981 | BP | L-asparagine biosynthetic process | The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid. |
ASNS |
GO:0070984 | MF | SET domain binding | Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation. |
WIZ |
GO:0070986 | BP | left/right axis specification | The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). |
NOTCH1, AHI1, MNS1, SETDB2, PITX2, CITED2, HSPB11 |
GO:0070987 | BP | error-free translesion synthesis | The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. |
UBC, PCNA, RPA3, RFC4, RFC2, RFC5, RFC3, VCP, RPS27A, UBA52, UFD1L, POLH |
GO:0070988 | BP | demethylation | The process of removing one or more methyl groups from a molecule. |
CYP1A1, CYP51A1 |
GO:0070989 | BP | oxidative demethylation | The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. |
CYP3A4, CYP2D6, CYP2C9, CYP3A5, ALKBH1, FTO |
GO:0070990 | MF | snRNP binding | Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle. |
PRPF31 |
GO:0070994 | BP | detection of oxidative stress | The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal. |
ADIPOQ |
GO:0070995 | BP | NADPH oxidation | A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP. |
FMO2 |
GO:0070996 | MF | type 1 melanocortin receptor binding | Interacting selectively and non-covalently with a type 1 melanocortin receptor. |
POMC, MRAP, MRAP2 |
GO:0070997 | BP | neuron death | The process of cell death in a neuron. |
DPYSL4, NLRP5, MAGI1, BAG5 |