| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0070435 | CC | Shc-EGFR complex | A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway. |
EGFR |
GO:0070436 | CC | Grb2-EGFR complex | A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway. |
GRB2, TNK2 |
GO:0070445 | BP | regulation of oligodendrocyte progenitor proliferation | Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation. |
CDH2 |
GO:0070446 | BP | negative regulation of oligodendrocyte progenitor proliferation | Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation. |
SIRT2 |
GO:0070447 | BP | positive regulation of oligodendrocyte progenitor proliferation | Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation. |
LYN |
GO:0070449 | CC | elongin complex | A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits. |
TCEB1, TCEB2 |
GO:0070458 | BP | cellular detoxification of nitrogen compound | Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. |
GSTM1, GSTM3, GSTM2 |
GO:0070459 | BP | prolactin secretion | The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary. |
ANXA1 |
GO:0070461 | CC | SAGA-type complex | A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
TADA2B, SGF29, USP22 |
GO:0070463 | MF | tubulin-dependent ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate. |
KIF18A |
GO:0070469 | CC | respiratory chain | The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. |
UQCRHL, UQCRQ, UQCR11, CYC1, CYCS, HIGD1A |
GO:0070471 | BP | uterine smooth muscle contraction | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth. |
AGT |
GO:0070474 | BP | positive regulation of uterine smooth muscle contraction | Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction. |
OXTR, ABAT, GPER1 |
GO:0070475 | BP | rRNA base methylation | The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. |
METTL15, NOP2, METTL16, EMG1 |
GO:0070481 | BP | nuclear-transcribed mRNA catabolic process, non-stop decay | The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon. |
PELO |
GO:0070487 | BP | monocyte aggregation | The adhesion of one monocyte to one or more other monocytes via adhesion molecules. |
IL1B, CD44 |
GO:0070488 | BP | neutrophil aggregation | The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules. |
S100A8, S100A9 |
GO:0070491 | MF | repressing transcription factor binding | Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription. |
ARNTL, GMNN, MYC, EIF4E, HMGB1, SKI, SKIL, TCF3, NFYB, SRI, CTNNB1, CBX5, HDAC4, HHEX, RELA, HDAC1, RUNX2, HDAC7, DDX20, HDAC9, HDAC5, NOC2L |
GO:0070492 | MF | oligosaccharide binding | Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. |
GYPC, SELE, DCBLD1, LOXL2 |
GO:0070493 | BP | thrombin receptor signaling pathway | The series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands. |
HPGD, F2R, F2RL1, IQGAP2 |
GO:0070495 | BP | negative regulation of thrombin receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands. |
SNCA |
GO:0070498 | BP | interleukin-1-mediated signaling pathway | A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IRAK2, RPS6KA5, IL1A, IL1R1, EGR1, MAPK3, IRAK1, PLCB1, IRAK3 |
GO:0070506 | MF | high-density lipoprotein particle receptor activity | Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis. |
SCARB1 |
GO:0070507 | BP | regulation of microtubule cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
EPHA3, EFNA5, DIXDC1, PHLDB2, PHLDB1, KIF18A, CYLD, RASSF1, CAMSAP3 |
GO:0070508 | BP | cholesterol import | The directed movement of cholesterol into a cell or organelle. |
LDLR, APOA1, CD36, SCARB1, STARD4 |
GO:0070509 | BP | calcium ion import | The directed movement of calcium ions into a cell or organelle. |
CASK, CACNA1G, CDK5, MCUR1, TRPV4, SLC30A1 |
GO:0070512 | BP | positive regulation of histone H4-K20 methylation | Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4. |
BRCA1 |
GO:0070513 | MF | death domain binding | Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB. |
DAPL1, DAP, CRADD, RIPK1, TRADD |
GO:0070522 | CC | ERCC4-ERCC1 complex | A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae. |
ERCC1, ERCC4 |
GO:0070524 | MF | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity | Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+. |
HSD11B1 |
GO:0070525 | BP | tRNA threonylcarbamoyladenosine metabolic process | The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. |
TP53RK |
GO:0070527 | BP | platelet aggregation | The adhesion of one platelet to one or more other platelets via adhesion molecules. |
CLIC1, FGA, FGB, FGG, HSPB1, ITGB3, PDGFRA, MYL12A, CSRP1, FLNA, MYL9, MYH9, PIK3CB, PIK3CG, ACTB, RAP2B, STXBP1, ACTG1, HBB, GNAS, TYRO3, ILK, GAS6, GNAS, SLC7A11, TLN1 |
GO:0070528 | BP | protein kinase C signaling | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. |
FLOT1, PDGFB, ZP3, HTR2B, ADGRG1 |
GO:0070530 | MF | K63-linked polyubiquitin binding | Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers. |
TNFAIP3, SQSTM1, OTUD7B, FAAP20, RNF169, ATRIP, OPTN, ZRANB1 |
GO:0070531 | CC | BRCA1-A complex | A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. |
BRCA1, BRCC3, BARD1 |
GO:0070534 | BP | protein K63-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. |
WWP2, PARK2, RNF8, UBE2B, UBE2V1, UBE2V2, UBE2S, RNF152, UBE2E3, ITCH, ZFP91, UBE2E2, RNF126, UBE2T, PRPF19, STUB1, UBE2D4 |
GO:0070535 | BP | histone H2A K63-linked ubiquitination | A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX. |
RNF8 |
GO:0070536 | BP | protein K63-linked deubiquitination | A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. |
USP27X, TNFAIP3, BRCC3, ATXN3, FAM175B, OTUD1, OTUD7B, USP13, OTUB2, CYLD, ZRANB1, USP25, USP20 |
GO:0070537 | BP | histone H2A K63-linked deubiquitination | A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX. |
BRCC3 |
GO:0070538 | MF | oleic acid binding | Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid. |
FABP3, SCP2 |
GO:0070539 | MF | linoleic acid binding | Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid. |
PPARD |
GO:0070541 | BP | response to platinum ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus. |
ALAD |
GO:0070542 | BP | response to fatty acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. |
GNPAT, TLR2, ASS1, FABP3, ALAD, CD36, PON1, CTGF, PTGS2, HMGCL, UCP2 |
GO:0070543 | BP | response to linoleic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus. |
CD36, ADIPOQ |
GO:0070544 | BP | histone H3-K36 demethylation | The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone. |
KDM7A, KDM2A |
GO:0070545 | CC | PeBoW complex | A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively. |
BOP1, WDR12, WDR37 |
GO:0070551 | MF | endoribonuclease activity, cleaving siRNA-paired mRNA | Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters. |
AGO2 |
GO:0070552 | CC | BRISC complex | A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains. |
BRCC3, FAM175B |
GO:0070554 | CC | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex | A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof). |
CPLX2 |
GO:0070555 | BP | response to interleukin-1 | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. |
IRAK2, RIPK2, ANXA1, IL1R1, ETS1, SELE, PRKCA, CHI3L1, SNCA, PRKCI, MTHFR, GCLC, HNMT, IRAK1, HDAC4, IGBP1, RELA, AES, SLC30A8, CITED1, YTHDC2, IRAK3, TNFRSF11A |
GO:0070557 | CC | PCNA-p21 complex | A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication. |
PCNA, CDKN1A |
GO:0070561 | BP | vitamin D receptor signaling pathway | The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands. |
VDR |
GO:0070563 | BP | negative regulation of vitamin D receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity. |
SNAI2, KANK2 |
GO:0070564 | BP | positive regulation of vitamin D receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity. |
CYP27B1 |
GO:0070572 | BP | positive regulation of neuron projection regeneration | Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. |
HGF |
GO:0070573 | MF | metallodipeptidase activity | Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
ACE, CPQ |
GO:0070574 | BP | cadmium ion transmembrane transport | A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
SLC11A1, SLC11A2, SLC39A8, SLC30A1 |
GO:0070576 | MF | vitamin D 24-hydroxylase activity | Catalysis of the hydroxylation of C-24 of any form of vitamin D. |
CYP1A1, CYP3A4 |
GO:0070577 | MF | lysine-acetylated histone binding | Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. |
BRD4, BRD2, SMARCA4, PSME4, BRD3, CARM1, PHIP, BRD7, BAZ1B |
GO:0070578 | CC | RISC-loading complex | A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. |
ZFP36, AGO4, AGO2, DICER1 |
GO:0070579 | MF | methylcytosine dioxygenase activity | Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2. |
ALKBH1 |
GO:0070584 | BP | mitochondrion morphogenesis | The process in which the anatomical structures of a mitochondrion are generated and organized. |
NDUFS6, SSBP1, BAX, MTM1, PID1, SUPV3L1, NUBPL, PNPT1, PANK2, SLIRP, MFF, POLDIP2 |
GO:0070585 | BP | protein localization to mitochondrion | A process in which a protein is transported to, or maintained in, a location within the mitochondrion. |
PARK2, DNAJA1 |
GO:0070588 | BP | calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
CACNA1G, ITGAV, ATP2A2, ATP2B1, ZP3, ATP2B4, TRPC1, PSEN1, NCS1, PKD1, ATP2C1, GRIN2A, TRPC3, PKD2, CACNA1C, GAS6, RYR3, CACNA1E, ANO6, DENND5A, DENND5B, TRPV1, TRPM4, TMEM37, CACNG8, CUL5, TRPM7, PANX1, ORAI2, ORAI3, TRPM6, CACNG6, TRPV6, TRPV4, SLC24A3, STIM2, TMCO1, TRPC6, TRPV2 |
GO:0070602 | BP | regulation of centromeric sister chromatid cohesion | Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome. |
CTNNB1 |
GO:0070603 | CC | SWI/SNF superfamily-type complex | A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. |
ATRX |
GO:0070611 | MF | histone methyltransferase activity (H3-R2 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3. |
PRMT6 |
GO:0070612 | MF | histone methyltransferase activity (H2A-R3 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A. |
PRMT6 |
GO:0070613 | BP | regulation of protein processing | Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. |
PRKACA, RPS6KA2 |
GO:0070615 | MF | nucleosome-dependent ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes. |
SMARCA1 |
GO:0070618 | CC | Grb2-Sos complex | A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. |
KHDRBS1 |
GO:0070625 | BP | zymogen granule exocytosis | The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions. |
SDF4 |
GO:0070626 | MF | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity | Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. |
ADSL |
GO:0070627 | BP | ferrous iron import | The directed movement of ferrous iron (Fe(II) or Fe2+) ions across a membrane into a cell or organelle. |
SLC11A2 |
GO:0070628 | MF | proteasome binding | Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation. |
UBD, PSMG1, ID1, ADRM1, USP13, UCHL5 |
GO:0070633 | BP | transepithelial transport | The directed movement of a substance from one side of an epithelium to the other. |
CXADR, GPLD1 |
GO:0070634 | BP | transepithelial ammonium transport | The directed movement of ammonium ions from one side of an epithelium to the other. |
SLC12A2, RHBG |
GO:0070640 | BP | vitamin D3 metabolic process | The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol. |
FGFR1 |
GO:0070644 | MF | vitamin D response element binding | Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. |
VDR, TCF3 |
GO:0070646 | BP | protein modification by small protein removal | A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. |
SENP6 |
GO:0070649 | BP | formin-nucleated actin cable assembly | The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. |
FMN2 |
GO:0070652 | CC | HAUS complex | A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex. |
HAUS5, HAUS6, HAUS1, HAUS7, HAUS4, HAUS2 |
GO:0070653 | MF | high-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a high-density lipoprotein receptor. |
APOA1, APOA2, APOC3 |
GO:0070661 | BP | leukocyte proliferation | The expansion of a leukocyte population by cell division. |
F2RL1 |
GO:0070662 | BP | mast cell proliferation | The expansion of a mast cell population by cell division. |
KIT |
GO:0070664 | BP | negative regulation of leukocyte proliferation | Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. |
GSTP1, CCL8 |
GO:0070667 | BP | negative regulation of mast cell proliferation | Any process that stops, prevents or reduces the rate or extent of mast cell proliferation. |
LYN |
GO:0070668 | BP | positive regulation of mast cell proliferation | Any process that activates or increases the rate or extent of mast cell proliferation. |
LYN, KITLG |
GO:0070669 | BP | response to interleukin-2 | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus. |
STAT5B, JAK3, CITED1 |
GO:0070670 | BP | response to interleukin-4 | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. |
STAT5B, JAK3, CITED1 |
GO:0070671 | BP | response to interleukin-12 | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus. |
RIPK2, JAK2 |
GO:0070672 | BP | response to interleukin-15 | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus. |
ACSL4, STAT5B, JAK3 |
GO:0070673 | BP | response to interleukin-18 | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus. |
RIPK2 |
GO:0070676 | BP | intralumenal vesicle formation | The invagination of the endosome membrane and resulting formation of a vesicle within the lumen of the endosome. |
SNX3 |
GO:0070679 | MF | inositol 1,4,5 trisphosphate binding | Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate. |
TRPC1, TRPC3, ITPR2, ITPR3, ITPR1, PLCL1, TRPC6 |
GO:0070681 | BP | glutaminyl-tRNAGln biosynthesis via transamidation | A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase. |
GATC, GATB, QRSL1 |
GO:0070682 | BP | proteasome regulatory particle assembly | The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex. |
PSMD10 |
GO:0070685 | CC | macropinocytic cup | A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin. |
SNX5 |
GO:0070688 | CC | MLL5-L complex | A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively. |
OGT, PPP1CC, ACTB, PPP1CA, PPP1CB, STK38, KMT2E |
GO:0070695 | CC | FHF complex | A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex). |
HOOK3, HOOK2, AKTIP |