GO:0061631

MF

ubiquitin conjugating enzyme activity

Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

UBE2QL1, UBE2C, CDC34, UBE2A, UBE2E1, UBE2D3, UBE2H, UBE2B, UBE2V2, UBE2S, UBE2J2, UBE2E3, UBE2E2, UBE2Z, UBE2T, UBE2D4

GO:0061635

BP

regulation of protein complex stability

Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly.

SQSTM1, SCOC

GO:0061646

BP

positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization

Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter.

RAB3GAP1

GO:0061649

MF

ubiquitinated histone binding

Interacting selectively and non-covalently with a histone protein in which a residue has been modified by ubiquitination. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.

USP15

GO:0061656

MF

SUMO conjugating enzyme activity

Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue.

UBE2I

GO:0061665

MF

SUMO ligase activity

Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.

ZNF451

GO:0061669

BP

spontaneous neurotransmitter secretion

Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential.

RIMS2

GO:0061676

MF

importin-alpha family protein binding

Interacting selectively and non-covalently with any member of the importin-alpha family.

GOLGA2, TPX2

GO:0061682

BP

seminal vesicle morphogenesis

The process in which the anatomical structures of a seminal vesicle are generated and organized.

ID4

GO:0061684

BP

chaperone-mediated autophagy

The autophagy process which begins when chaperones and co-chaperones recognize a KFERQ-related motif and unfold the substrate protein. The process ends with the catabolism of the protein in the lysosome.

HSP90AA1, LAMP2

GO:0061689

CC

tricellular tight junction

An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet.

LSR

GO:0061700

CC

GATOR2 complex

A multiprotein subcomplex of GATOR that regulates mTOR signaling by interacting with the Rag GTPases. In humans this complex consists of Mios, WDR24, WDR59, Seh1L, Sec13.

SEC13, SESN2, SESN3, SEH1L, SESN1

GO:0061709

BP

reticulophagy

The autophagic process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.

RB1CC1

GO:0061712

MF

tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase

Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine.

CDKAL1

GO:0061713

BP

anterior neural tube closure

The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline.

FOLR1

GO:0061714

MF

folic acid receptor activity

Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis.

FOLR1

GO:0061723

BP

glycophagy

The autophagic process in which cellular glycogen is delivered to the vacuole and degraded in response to changing cellular conditions.

RB1CC1

GO:0061724

BP

lipophagy

The autophagic process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions.

RAB7A

GO:0061732

BP

mitochondrial acetyl-CoA biosynthetic process from pyruvate

The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA.

PDHA1, DLD, PDHB

GO:0061734

BP

parkin-mediated mitophagy in response to mitochondrial depolarization

The macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule.

PARK2, MFN2, OPTN

GO:0061738

BP

late endosomal microautophagy

The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment.

VPS4B

GO:0061743

BP

motor learning

Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience.

DKK1

GO:0061752

MF

telomeric repeat-containing RNA binding

Interacting selectively and non-covalently with long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats.

KDM1A, HNRNPA1

GO:0065001

BP

specification of axis polarity

The pattern specification process in which the polarity of a body or organ axis is established and maintained.

AHI1

GO:0065002

BP

intracellular protein transmembrane transport

The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.

AKT2, C2CD5

GO:0065004

BP

protein-DNA complex assembly

The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.

SOX12, TCF4

GO:0065010

CC

extracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.

ALPL

GO:0070006

MF

metalloaminopeptidase activity

Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

MMP14, METAP2, MMP15, MMP16, NPEPPS, ERAP2, AOPEP, ERAP1, LNPEP, LOC440434

GO:0070008

MF

serine-type exopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

PREP, PREPL

GO:0070012

MF

oligopeptidase activity

Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.

NDEL1

GO:0070016

MF

armadillo repeat domain binding

Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation.

CNOT1, AXIN1, STRN3, CHD8, TCF7L2, STRN4

GO:0070022

CC

transforming growth factor beta receptor homodimeric complex

A homodimeric receptor complex that consists of two TGF-beta receptor monomers.

TGFBR1, TGFBR2, DAB2

GO:0070025

MF

carbon monoxide binding

Interacting selectively and non-covalently with carbon monoxide (CO).

CBS

GO:0070026

MF

nitric oxide binding

Interacting selectively and non-covalently with nitric oxide (NO).

GSTP1, CBS

GO:0070032

CC

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).

SNAP25, VAMP2

GO:0070033

CC

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).

VAMP2, CPLX2

GO:0070034

MF

telomerase RNA binding

Interacting selectively and non-covalently with the telomerase RNA template.

DKC1, HNRNPC, SNRPB, SNRPD3, HNRNPU, NAF1, TEP1, NOP10, GAR1, SMG5

GO:0070037

MF

rRNA (pseudouridine) methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule.

EMG1

GO:0070039

MF

rRNA (guanosine-2'-O-)-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine.

MRM1

GO:0070044

CC

synaptobrevin 2-SNAP-25-syntaxin-1a complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).

VAMP2

GO:0070050

BP

neuron cellular homeostasis

The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.

PARK2, TYRO3, NELL2

GO:0070051

MF

fibrinogen binding

Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.

THBS1, FBLN1

GO:0070052

MF

collagen V binding

Interacting selectively and non-covalently with a type V collagen trimer.

ECM2, THBS1

GO:0070053

MF

thrombospondin receptor activity

Combining with thrombospondin and transmitting the signal to initiate a change in cell activity.

F2, CD36, SDC4, CD47

GO:0070054

BP

mRNA splicing, via endonucleolytic cleavage and ligation

Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.

ERN1

GO:0070055

BP

mRNA endonucleolytic cleavage involved in unfolded protein response

The endonucleolytic cleavage of a mRNA containing an HAC1-type intron at the 5' and 3' splice sites. The cleavage step is part of unconventional mRNA splicing, and contributes to the endoplasmic reticulum unfolded protein response.

ERN1

GO:0070059

BP

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

ERN1, PPP1R15A, AIFM1, BCL2, CEBPB, XBP1, ATF4, DDIT3, CASP4, GSK3B, BAX, PMAIP1, ITPR1, DNAJC10, ERO1A, TRIB3, MAP3K5, CHAC1

GO:0070060

BP

de novo' actin filament nucleation

The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament.

JMY

GO:0070061

MF

fructose binding

Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose.

ALDOA, PFKL, SLC2A5

GO:0070062

CC

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

VPS37C, MYO1G, IGLL5, ACOT7, MYO1C, SNAP23, MASP2, RAB27B, LGALS8, PSMD11, PSMD12, AGRP, CLIC1, WWP2, WASL, PIK3C2A, PLOD2, NDUFA4, CHL1, SDCBP, DDX3X, RNASET2, KPNA4, MAN2B1, FBP2, PDXK, PLPP1, PLPP3, ISLR, ENPP3, CHD2, TOR1A, ADAM10, ITGB1BP1, PDCD5, TPP1, MGST3, IRF6, TAX1BP3, RAB29, SLC27A2, HNRNPDL, PLXNB2, PFAS, NPC1, SCAMP2, ARPC2, ARPC3, PLSCR1, CTDSPL, KMO, PMM2, STX7, CAPN5, CLDN3, FLRT2, PHGDH, PSMD3, B4GALT5, EEF1E1, COCH, MGAM, AKR7A2, B4GAT1, CHMP2A, TSPAN6, ASNA1, PI15, ACTN4, ITM2A, SYNGR2, EDIL3, AHCYL1, CD5L, GNG7, SPAG9, TBC1D4, PPL, LY75, ACSL4, SNX3, GMDS, SELENOF, PDE8A, UGDH, TPST2, CTNND1, EDF1, DNAJA2, FCGR3B, WDR1, CILP, PDCD6, ATP6V1G1, VPS4B, MPDU1, ENTPD6, H2AFY, FLNB, VPS26A, TECTA, GPC4, CLN5, BANF1, LYPLA1, CREG1, RP2, IDH1, TNFSF13, ALDH1L1, RASSF9, ARL6IP5, ATP5H, FLOT1, ATP5L, NEBL, SEC14L2, WISP2, SLC22A5, DDAH1, SLIT2, MYO1D, TMEM63A, PROSC, ERLIN2, RHOBTB3, CLSTN1, PRSS23, NDUFB4, PGLS, SMC2, LYPLA2, VNN1, SFT2D2, STAMBP, WIZ, STAU1, CLIC3, ANGPTL1, DDAH2, EFEMP2, NUDT3, NDUFB10, TOMM40, PEX11B, CYB5A, LDHA, ALDH1A1, CYB5R3, GSR, PNP, GOT2, PGK1, AK1, F2, C1R, HP, PLG, PLAU, PLAT, CFB, CA2, ASS1, SPINK1, SERPINC1, SERPINA1, SERPINA3, AGT, A2M, C3, TIMP1, CST3, CSTA, KNG1, NRAS, FSHB, LHB, IGF2, IL1B, HLA-DRA, CRYAB, APOA1, APOE, APOA2, APOC1, APOC3, FGA, FGB, FGG, PMP2, GYPA, CRP, APCS, C1QA, APOH, LRG1, FN1, RBP4, AMBP, ORM1, AHSG, TTR, ALB, GC, TFRC, TF, FTL, FTH1, ANG, SLPI, VTN, FUCA1, ALDOA, CSTB, ANXA1, APOB, PRNP, SOD2, A1BG, CD74, KRT1, VWF, SHBG, TUBB4A, GAPDH, HSPB1, GNAI2, ATP1B1, APP, APOD, ALDH2, ITGB3, ITGB2, S100A8, SERPINE1, SLC25A5, SERPINA5, SERPING1, CFI, MPO, ALPL, EIF2S1, ICAM1, RPLP1, RPLP2, RPLP0, FABP3, CLEC3B, ITGB1, PRKCB, KRT18, KRT8, INSR, PTMA, CDK1, S100A9, S100A6, EIF4E, ENO1, GPI, TPM3, ITGAV, LPL, HEXA, DBI, LDHB, GPX1, P4HB, KLK3, ACYP1, CTSD, ANXA2, C8G, TUBB, PRSS1, PSAP, CTSL, PFN1, BPGM, APRT, CTSB, HSP90AA1, HNRNPC, LAMB1, LYN, FH, THBS1, RNASE1, COL1A2, ANXA6, CD55, SLC3A2, HSP90AB1, GSTA1, SOD3, MME, MGP, CD14, COL4A2, PTPRC, MFI2, CFH, VIM, RPS17, KRT19, KRT7, GNAI3, ANXA5, KRT16, RPSA, ENO2, GSTP1, CD48, LGALS1, QDPR, FBP1, ANXA4, CNP, PDGFRB, HNRNPA1, CTSH, FGR, C1S, UCHL1, FURIN, ALDOC, C4A, C4B, H2AFZ, HIST1H2AG, CHTF8, GSTT2, UBC, SAA1, SAA2, RAP2A, RNASE2, GAA, RRAS, HIST1H1E, SPP1, PTPRF, TXN, COX5B, C7, HSPD1, CLU, HSPA5, LAMC1, SLC2A1, SLC2A3, PDHB, ITGAM, PYGB, PYGM, RALA, RALB, BCR, LAMP1, G6PD, MTHFD1, IGF2R, PRPS2, PCNA, KRT3, COL6A1, COL6A2, COL6A3, CKB, FCGR2A, ANXA3, CKMT1A, BMP3, ACTN1, ACE, LAMP2, RNH1, CFTR, NCAM1, EEF2, KRT13, C6, TPT1, ALAD, PRG2, HLA-E, LCP1, PRKAR2A, ENO3, MIF, CPM, NID1, PLA2G2A, PKM, HSP90B1, MYL6B, SLC2A4, SNRPB, MMP9, HNRNPL, DARS, JUP, FABP4, AKR1B1, PVR, RAC2, ARSA, B4GALT1, ACPP, EZR, FOLR1, UCHL3, HPGD, CD46, NME1, NQO1, GNS, ARSB, RPS2, ST6GAL1, DSP, MUC1, TIMP2, CD44, NQO2, H2AFX, ITGB4, CBR1, PECAM1, EPCAM, GNB3, CPE, PLCG2, FAH, STMN1, HSPA6, RHOQ, PRKCA, GJA1, NPR3, PRKACA, DES, DDX5, PFKL, GM2A, CR1, LGALS3, IGFBP3, TCP1, IGFBP2, RPL35A, ITGB5, ARF4, RPL7, IL1RN, PGAM1, SDC1, PAM, CDH2, TSPAN8, MYL12A, CD58, VCAM1, CD53, ORM2, AMY2B, ATP2B1, CD33, KLK2, RAB3B, RAB5A, PSMB1, HIST1H2AD, COX5A, OGN, EFNA1, COL5A1, GSTM3, ATP6V1B2, ATP6V1C1, CSRP1, FLNA, TNFAIP3, NT5E, BGN, SDHB, CD9, COMT, TGM2, PCMT1, GART, TNXB, PAICS, SCP2, UBA1, GPX3, NME2, HNRNPA2B1, UQCRC2, SLC2A5, CA4, FBLN1, PTGS1, PPIB, PTPRD, PTPRG, AHCY, CFL1, RRM1, LAMA2, IGFBP6, AZGP1, MPST, FAS, DNAJB1, PSMA1, PSMA2, PSMA3, PSMA4, S100P, COL5A3, ITGA3, ITGB8, S100A4, PTBP1, TARS, CD27, FKBP2, MST1, STOM, AK4, PON1, MAOB, MAPK3, DPP4, CAD, CALR, CANX, PSMB8, PSMB9, PSMB4, PSMB5, GSTM2, MAPK1, GRN, LAP3, TNFRSF8, IMPA1, TKT, SERPINB3, MARCKS, GNA11, PBLD, ERP29, PRDX6, BLVRB, DDT, RPL12, ECHS1, CMPK1, PEBP1, PDIA3, PPP2R1A, PPP2R1B, ADSS, TSPO, SRI, GSTT1, SERPINB1, CORO1A, S100A7, PRKAR2B, FGF9, SDC4, DNAJA1, YWHAB, SFN, S100A11, PRDX2, GK, DCTD, STX2, CTH, LSP1, DUT, ABCC1, MAN1A1, GALNS, RNASE4, SHMT1, HSPA4, PRSS3, GPC1, CTNNB1, PHB, RDX, RPL22, THBS4, KRT9, FBN1, PCK1, MYH9, ACTN2, BSG, TIMP3, MYH11, GLRX, CHI3L1, TRIM23, ATP5C1, RPL4, NUDT1, PGM1, ACVR1B, SERPINB5, SERPINF1, DLST, GPX4, SCNN1A, SRP14, HPCAL1, TAGLN2, TALDO1, RBMX, LIPA, COL15A1, COL18A1, CAPG, IL6ST, CCT6A, MDH1, MDH2, EIF2S3, AQP2, MNDA, WNT5A, PTGDS, CSK, PRKCI, ACTR1B, ECI1, AKR1C3, DPP6, LIFR, ECE1, SLC1A4, NAMPT, PPIC, VDAC2, ACADSB, CRKL, NSF, RPL5, RPL28, RPS9, RPS5, RPS10, GNPDA1, IQGAP1, CAPZB, ALDH1A3, LGALS7, ATP5O, CXCL12, SERPINB4, PRRC2A, IDH2, PITPNB, CD97, MAPKAPK2, ALDH9A1, RPL34, TGM4, FASN, CCT3, ALDH7A1, SRP9, SARS, PSMB3, COMP, TMED10, HINT1, RARRES1, FHIT, SEPP1, HNMT, GNAQ, GNG4, GDI2, GATM, SLC26A2, SERPINB9, SERPINH1, TNFSF10, BCAM, PPT1, RPL14, CCT8, ANXA11, RAB5C, RAB7A, RAB9A, RAB27A, SCNN1G, PLCD1, DUSP3, SSR4, TPMT, ALDH3A2, PSMD7, SGSH, ARSD, VAMP7, LUM, PGD, HNRNPM, RAP1GDS1, ARHGDIA, ARHGDIB, HRSP12, CAPZA1, SLC25A1, SUCLG1, COPA, CTSC, PTTG1IP, IST1, SUB1, POLG, CRISP3, RARS, HIRA, CACNA2D1, PRKAG1, ATP1B3, EPHB4, EPHB1, NAGLU, GALC, SLC12A2, CSE1L, VCP, HADHB, INHBC, CDH6, CDH11, CDH13, CDH15, SEC13, NPEPPS, SUMO3, EIF3B, BID, EIF6, WNT3, GEMIN4, MTPN, HIST1H2BD, ZNF445, ARPC4, CD81, TPI1, MYL6, ACTB, RAC3, EIF4A1, RPS20, S100A10, CDC42, DSTN, RAB2A, RAB5B, CXCR4, UBE2D3, UBE2M, ACTR3, ACTR2, RAP2B, RPS3A, RPL26, RPL15, RPL27, ATP6V0D1, RPL37A, RHOA, NCALD, HSPE1, LYZ, STXBP1, B2M, DAD1, NPC2, UFM1, AP1S1, NUTF2, RRAS2, RPS7, PPP1CA, PPP1CB, CALM2, NCS1, RPS8, RPS15A, RPS16, YWHAE, RPS14, RPS18, RPS13, RPS11, LSM6, SNRPD2, SNRPD3, PSMC6, RPL7A, RAB11A, PPP2CB, ACTA2, RHOB, RPL23A, HIST1H4A, HIST1H2BC, RAB1A, RAP1A, RPS25, RPS26, GNB1, GNB2, RPL30, RPL31, RPL10A, RPL11, PPIA, RPS27A, UBA52, GRB2, RAC1, VAMP2, GNAI1, YWHAZ, DYNLL1, SKP1, GNG5, EIF5A, RACK1, ACTG1, ACTG2, YBX1, TPM4, ACTC1, EEF1A1, TUBA1B, TUBA4A, TUBB4B, PAFAH1B2, HIST1H3D, HBB, HBA1, SIRPA, CCT2, OLR1, GSTO1, BLOC1S1, BTG2, GPLD1, LCN2, NUCB2, ABAT, RPL24, ARF1, ARF5, H3F3A, GNAS, DAB2, MUC5AC, FBLN2, HSPG2, PKD1, LRP2, PITPNA, SLC25A3, REEP5, SORD, SPTBN1, SRSF2, CTBS, FABP5, IFITM3, SLC7A5, XPC, OCRL, ALDH6A1, DSC2, MAP2K1, FKBP4, PLOD1, NUCB1, CREB5, DST, TGFBR3, PLAUR, MVK, CFHR1, GBE1, KRT17, GLO1, AKR1C1, SSBP1, YWHAH, PRKCD, COL14A1, GFPT1, EXOSC9, AOX1, APLP2, PRDX1, BAX, SRSF1, CRYZ, IL10RB, DDR1, SLC20A2, MFGE8, CD47, AHNAK, ZNF763, GALNT2, BST2, FUT2, ST3GAL1, ST3GAL4, KCNMA1, EFEMP1, FSTL1, STX4, CNTN1, PTPRJ, EPS8, DLG1, MYO1E, PTP4A2, ECH1, COASY, SPP2, MTAP, PRDX4, PSMD2, SEMA3B, DNAJC3, SELENBP1, STX3, UBE2V1, SNTB2, GOLGA4, ADAM9, FKBP5, MTM1, SQSTM1, TUBB3, ASAH1, DCTN2, PKD2, IQGAP2, SEMA5A, MTMR2, CUL3, CUL4B, ALCAM, SHROOM2, BLMH, TUBB2A, COTL1, HNRNPD, NID2, IL18, DAG1, DSG2, DYNC1H1, CTTN, FGL2, GALE, GAS6, WFDC2, SPARCL1, FAT1, NBR1, INPP5A, PLS1, GANAB, RFTN1, PTGR1, KPNB1, CLCA4, SEPT2, RAB3GAP1, EEA1, PDIA6, PAFAH1B3, PCOLCE, PTGES3, PPP2R4, QPRT, PCBP1, TCEB2, RHEB, ANGPT1, PPP1R7, FCN2, TGFBI, TRIP10, MYLK, SLC1A5, UBE2V2, STK11, STXBP2, NEDD8, ADIRF, ADIPOQ, RAB11B, SEPT7, IGFBP7, PDCD2, SLC15A2, LAMA4, MAPK14, CDC37, DPYSL2, FSCN1, DECR1, QPCT, HAGH, HIST2H2BE, LAMA3, PCK2, PTPRO, UGP2, ATP6V1F, TXNRD1, TMEM132A, SPHKAP, IAH1, HLA-DRB5, TKFC, ZSCAN23, ALDH1L2, ANO6, PABPC1L, GREB1, C11orf73, PLA1A, COBLL1, TAF1B, CYBRD1, IGSF11, MEST, MUM1L1, NHLRC3, GNAS, COLEC12, MUC21, FNBP1L, EYS, WLS, CROCC, STRIP1, CDC42BPA, LRRC16A, CD276, CPZ, STEAP4, DMKN, HIST2H2AA3, PTRHD1, LAIR1, LAMTOR1, TWF2, NAPEPLD, NIPBL, TCTN3, HIBCH, SLC39A4, OGFOD3, ATAD2, POTEE, CSPG4, SBSN, C5orf46, CES3, OLFM4, PLXDC2, PI16, KIAA1324, THSD4, GBP6, SLCO4C1, FAM65A, VPS13C, TUBA1A, H2AFV, BTN2A1, CYFIP1, COPS6, HIST3H2A, MON2, TMC6, HDDC2, C6orf120, DCXR, SDK1, HUWE1, TMED4, GALNT7, OAF, RTN4RL1, ALYREF, SERINC5, TAX1BP1, CAND1, SLC26A11, LSR, AEBP1, HID1, SLC44A2, TEX14, ZBTB8OS, FAM20C, CPNE9, PM20D2, ALDH16A1, KIAA0319L, ABI1, TMEM256, MPP5, SFRP1, GALNT4, MINK1, TAB3, ARRDC1, COMMD1, CD177, PDDC1, GOLM1, UXS1, RNF149, SERBP1, GSTCD, APPL2, ATP6V1C2, GPRC5A, CASC5, SVIP, INADL, ZNF420, TBC1D15, NT5C, SPPL2A, BPIFB1, SNX29, SCARB1, RAB2B, PDCD6IP, MITD1, N6AMT2, NUDCD2, SECTM1, BTN2A2, ITLN1, SLC44A1, PHIP, GPR98, SYNE2, AHCTF1, TTN, FAM3C, NDRG1, HSPH1, DOCK2, SORL1, ANP32B, TFG, RYR2, HTRA1, N4BP2L2, GGH, BCL2L2, KIFAP3, GLG1, SLC5A5, RAB8B, ATP6V0A1, EXT2, HIST1H2AC, HIST1H2BH, PTP4A1, HGD, MYDGF, MAL2, TMBIM1, C11orf52, TMEM106A, FAM162A, ARL8A, PTER, DOCK10, AP2M1, KCTD12, MVB12A, CYFIP2, SAT2, CPNE2, S100A16, OTUB1, PGM2, ZNF486, ABHD14B, CPB2, ITCH, LOXL4, PDLIM2, HS6ST2, CLIC6, PGLYRP2, NEDD4L, VPS35, SNX18, MYADM, SERINC2, SPEN, FAM129B, MUC4, NEU1, MPHOSPH8, P2RX4, SERPINI1, S100A13, DNAJC7, PHB2, COPS8, CHP1, COL12A1, TM9SF2, CIB1, CCT7, SH3GL2, RARRES2, OMD, SEMA3C, GDF15, AIF1L, CORO1B, CPPED1, SDF4, FAM213A, ERP44, LXN, AGMAT, PRADC1, UPK3B, H2AFJ, FUCA2, DHRS4, SPON2, TUBB6, PDCD10, DDX23, BDH2, ABHD6, MLPH, DUSP26, DUSP23, GGACT, NUDT9, ACAT2, C1QTNF3, TMEM59, OSBPL1A, CADM1, FUT8, CDHR2, PARD6B, UACA, RAB34, FAM129A, UBXN6, TINAGL1, PDGFD, CTDSP1, NAA50, IQCG, CRISPLD2, TOLLIP, RACGAP1, WWP1, RAB1B, C11orf54, NAPB, SDCBP2, CYSTM1, TRPV6, WNT5B, EHD4, SPTBN4, SH3BGRL3, ALDH8A1, SLC38A1, DHX36, PPA2, CRISPLD1, PABPC3, GHITM, BOLA2, MUC13, CHMP4B, TOR3A, TUBB1, RHOJ, GLIPR2, GSTO2, METTL7A, MOB1A, SCPEP1, CACYBP, ROBO2, TMEM8A, CD248, RETN, APMAP, CD209, ABCB6, VTA1, CD320, ACOT13, PLCB1, CRTAC1, GPRC5C, RTN4, HINT3, XPNPEP3, MAN1C1, ASH1L, MXRA5, PDGFC, DUOX2, AASDHPPT, PLSCR4, CDC42SE2, PHPT1, SERINC1, LTBP3, TM7SF3, ECHDC1, GINM1, TMEM106B, LIN7C, ARL8B, C1orf123, B3GNT2, HAO2, UGGT1, ERAP1, CISD1, CLIC5, GLTP, GPRC5B, MAT2B, ITSN2, C1RL, CRIM1, MPP6, NDUFA13, H2AFY2, SH3BP4, ARHGAP23, MBD5, ANKFY1, SUCLA2, SPRR3, CLCF1, SPAST, VPS29, EIF3K, GRHPR, CTSZ, DNAJB9, CTSF, UQCR10, DNAJB4, KL, MIOX, DMBT1, FETUB, LAMTOR3, PCYOX1, SLC7A8, BAIAP2L1, ATP6V1H, SERPINB13, PLXNA1, GNPTG, TNIK, PILRA, NUDT5, VAV3, PCOLCE2, RAB21, RAB22A, RAB23, MYO5B, FZD4, MGAT4A, EPDR1, MYO6, PPT2, SNX12, NDRG2, PCDHGC3, SLC6A14, STUB1, PROCR, MINPP1, THSD7A, RIMS2, PA2G4, RUVBL2, PIN4, PLAA, RUVBL1, ST3GAL6, VDAC3, VSIG4, ITM2B, MAN2B2, GSTK1, LAMTOR2, CRYL1, CARHSP1, THRAP3, DERA, SH3GLB1, CAB39, HBS1L, TLN1, KIF3A, MYO5A, HYOU1, SAMM50, HSPB11, ATP6V1D, GMPPB, MMP24, CDC42BPB, SNX9, LYVE1, HEBP2, PSAT1, F11R, CPQ, ADGRG1, STK24, WNT6, TEX264, NCOA3, SLC4A4, PCLO, WASF2, ENPP4, LOC440434

GO:0070063

MF

RNA polymerase binding

Interacting selectively and non-covalently with an RNA polymerase molecule or complex.

BIN1, CCNT1, CCNT2, PPIB, ZFP36, STOM, TAF10, PKN2, PABPN1, ANP32B, YTHDC2, RRN3, PHRF1

GO:0070064

MF

proline-rich region binding

Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.

APBB1, PRPF40A, PFN1, GHR, CSK, YAP1, ITSN1, GAREM1, CYLD, ABI2, BAIAP2L1

GO:0070072

BP

vacuolar proton-transporting V-type ATPase complex assembly

The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane.

TCIRG1, ATP6V0A1

GO:0070076

BP

histone lysine demethylation

The modification of a histone by the removal of a methyl group from a lysine residue.

UBE2B

GO:0070078

BP

histone H3-R2 demethylation

The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone.

JMJD6

GO:0070079

BP

histone H4-R3 demethylation

The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone.

JMJD6

GO:0070080

MF

titin Z domain binding

Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.

ACTN2

GO:0070083

CC

clathrin-sculpted monoamine transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle.

SYT1, VAMP2, SLC18A2

GO:0070084

BP

protein initiator methionine removal

The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein.

METAP2

GO:0070085

BP

glycosylation

The covalent attachment and further modification of carbohydrate residues to a substrate molecule.

CLN5, COG6

GO:0070086

BP

ubiquitin-dependent endocytosis

Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded.

NEURL1B

GO:0070087

MF

chromo shadow domain binding

Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.

SP100, ATRX, CHAF1A, TRIM28, NIPBL

GO:0070091

BP

glucagon secretion

The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).

IL6

GO:0070092

BP

regulation of glucagon secretion

Any process that modulates the frequency, rate or extent of the regulated release of glucagon.

PASK

GO:0070093

BP

negative regulation of glucagon secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.

LEP, CARTPT

GO:0070095

MF

fructose-6-phosphate binding

Interacting selectively and non-covalently with fructose 6-phosphate.

PFKFB1, PFKL

GO:0070096

BP

mitochondrial outer membrane translocase complex assembly

The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex.

TOMM20

GO:0070097

MF

delta-catenin binding

Interacting selectively and non-covalently with the delta subunit of the catenin complex.

PTPRJ, DACT3, DACT1

GO:0070098

BP

chemokine-mediated signaling pathway

A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

PPBP, PF4, CXCL1, CXCL8, CCL3, CCL4, CCL2, CCL5, CXCL2, CXCR2, CXCL5, CXCL12, CXCR4, CCL20, CCL8, CXCL6, ACKR4

GO:0070100

BP

negative regulation of chemokine-mediated signaling pathway

Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.

SLIT2, CCL5

GO:0070101

BP

positive regulation of chemokine-mediated signaling pathway

Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.

EDN1, HIF1A

GO:0070102

BP

interleukin-6-mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IL6, IL6R, IL6ST, STAT3, GAB1, SMAD4

GO:0070104

BP

negative regulation of interleukin-6-mediated signaling pathway

Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.

PTPN2

GO:0070106

BP

interleukin-27-mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IL6ST

GO:0070110

CC

ciliary neurotrophic factor receptor complex

A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR.

IL6R, IL6ST

GO:0070119

MF

ciliary neurotrophic factor binding

Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor.

IL6R

GO:0070120

BP

ciliary neurotrophic factor-mediated signaling pathway

A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IL6R, IL6ST, LIFR

GO:0070121

BP

Kupffer's vesicle development

The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.

AHI1

GO:0070123

MF

transforming growth factor beta receptor activity, type III

Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.

TGFBR3

GO:0070124

BP

mitochondrial translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.

MTIF3

GO:0070125

BP

mitochondrial translational elongation

The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion.

MRPS12, MRPS14, MRPL33, TSFM, MRPL19, DAP3, MRPL12, MRPS25, MRPS10, MRPS5, MRPS36, MRPS21, MRPS34, ICT1, MRPL23, MRPL51, MRPL54, MRPL14, MRPL21, MRPL55, MRPL52, MRPL41, MRPL50, GADD45GIP1, MRPL30, MRPS31, CHCHD1, MRPL38, PTCD3, MRPL48, GFM1, MRPL34, MRPL32, MRPL4, MRPL1, MRPS26, MRPL37, MRPL44, MRPL47, MRPL40, MRPL17, MRPS18A, AURKAIP1, MRPL16, MRPL35, MRPL15, MRPL36, MRPS28, MRPS18B, MRPL42

GO:0070126

BP

mitochondrial translational termination

The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).

MRPS12, MRPS14, MRPL33, MRPL19, DAP3, MRPL12, MRPS25, MRPS10, MRPS5, MRPS36, MRPS21, MRPS34, ICT1, MRPL23, MRPL51, MRPL54, MRPL14, MRPL21, MRPL55, MRPL52, MRPL41, MRPL50, GADD45GIP1, MRPL30, MRPS31, CHCHD1, MRPL38, PTCD3, MRPL48, MRPL34, MRPL32, MRPL4, MRPL1, MRPS26, MRPL37, C12orf65, MRPL44, MRPL47, MRPL40, MRPL17, MRPS18A, AURKAIP1, MRPL16, MRPL35, MRPL15, MRPL36, MRPS28, MRPS18B, MRPL42

GO:0070127

BP

tRNA aminoacylation for mitochondrial protein translation

The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion.

EARS2

GO:0070129

BP

regulation of mitochondrial translation

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.

LRPPRC, MTG1, MTG2

GO:0070130

BP

negative regulation of mitochondrial translation

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.

MALSU1

GO:0070131

BP

positive regulation of mitochondrial translation

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.

C1QBP, UQCC2, COA3

GO:0070139

MF

SUMO-specific endopeptidase activity

Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO.

SENP5

GO:0070141

BP

response to UV-A

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm.

EGFR, AKT1

GO:0070142

BP

synaptic vesicle budding

Evagination of a membrane to form a synaptic vesicle.

ARF1

GO:0070164

BP

negative regulation of adiponectin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell.

RAB11FIP3, IL1B, RAB11FIP1

GO:0070165

BP

positive regulation of adiponectin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.

C1QTNF3

GO:0070166

BP

enamel mineralization

The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel.

TBX1, PPARA, FOXO1, NECTIN1, WDR72, FAM20C

GO:0070168

BP

negative regulation of biomineral tissue development

Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.

AHSG, SOX9, GAS6

GO:0070172

BP

positive regulation of tooth mineralization

Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.

WNT6

GO:0070176

CC

DRM complex

A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification.

LIN52

GO:0070180

MF

large ribosomal subunit rRNA binding

Interacting selectively and non-covalently with the large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.

RPLP1, RPLP2, RPLP0, RPL19, MRTO4

GO:0070181

MF

small ribosomal subunit rRNA binding

Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.

RPS14, RPS13, CIRBP, UTP23

GO:0070182

MF

DNA polymerase binding

Interacting selectively and non-covalently with a DNA polymerase.

CDK2AP1, HMGB1, PCNA, SMARCA4, RAD51, ACD, FANCD2, FANCI, SMG5

GO:0070187

CC

telosome

A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.

TERF1, ACD, POT1

GO:0070189

BP

kynurenine metabolic process

The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine.

KMO