Search Geneontologies

Geneontologies

GO ID Ontology GO Term Term Definition Proteins

GO:0060612

BP

adipose tissue development

The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.

SH3PXD2B, LRP5, XBP1, LEP, PIK3CA, OXCT1, SOX8, ID2, PPARD, ARID5B, AACS, SPG20, FTO, EBF2, PPARGC1A

GO:0060613

BP

fat pad development

The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue.

ARID5B, ARRDC3, DGAT2, TBL1XR1

GO:0060615

BP

mammary gland bud formation

The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis.

FGFR2

GO:0060620

BP

regulation of cholesterol import

Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle.

LAMTOR1

GO:0060621

BP

negative regulation of cholesterol import

Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle.

APOA2, APOC3

GO:0060623

BP

regulation of chromosome condensation

Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

CCNB1, WAPL

GO:0060627

BP

regulation of vesicle-mediated transport

Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.

NRP1, USP6, RAB11A, VAMP2, SLC30A8

GO:0060628

BP

regulation of ER to Golgi vesicle-mediated transport

Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.

GAS1, YIPF5

GO:0060632

BP

regulation of microtubule-based movement

Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

MAPT, IGBP1, HDAC6

GO:0060633

BP

negative regulation of transcription initiation from RNA polymerase II promoter

Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.

ZNF451

GO:0060638

BP

mesenchymal-epithelial cell signaling

Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted.

WNT5A, WNT2B

GO:0060644

BP

mammary gland epithelial cell differentiation

The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.

IRF6, PRLR, CEBPB, AKT1, AKT2, PTCH1, ERBB4, ELF5

GO:0060648

BP

mammary gland bud morphogenesis

The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord.

SOSTDC1

GO:0060661

BP

submandibular salivary gland formation

The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed.

CDC42

GO:0060662

BP

salivary gland cavitation

The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland.

NFIB, TGM2

GO:0060664

BP

epithelial cell proliferation involved in salivary gland morphogenesis

The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland.

TNF, IL6, FGFR2

GO:0060665

BP

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium.

FGFR1, HGF, FGF7

GO:0060666

BP

dichotomous subdivision of terminal units involved in salivary gland branching

The process in which a salivary epithelial cord bifurcates at its end.

NRP1, SEMA3A, SEMA3C, PLXNA1, PLXND1

GO:0060667

BP

branch elongation involved in salivary gland morphogenesis

The differential growth of the salivary branches along their axis, resulting in the growth of a branch.

FGFR2

GO:0060668

BP

regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling

Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland.

NTN4

GO:0060669

BP

embryonic placenta morphogenesis

The process in which the embryonic placenta is generated and organized.

CDKN1C, TRIM28

GO:0060670

BP

branching involved in labyrinthine layer morphogenesis

The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.

SOCS3, FGFR2, IL10, ADM, GRB2, RSPO3

GO:0060672

BP

epithelial cell morphogenesis involved in placental branching

The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta.

SPINT2

GO:0060674

BP

placenta blood vessel development

The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure.

ARID1A, SOCS3, FOSL1, NR2F2, ITGB8, PKD1, MAP2K1, PKD2, RBM15

GO:0060675

BP

ureteric bud morphogenesis

The process in which the ureteric bud is generated and organized.

HES1

GO:0060676

BP

ureteric bud formation

The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud.

GREM1

GO:0060683

BP

regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling

Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland.

PDGFA

GO:0060684

BP

epithelial-mesenchymal cell signaling

Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted.

BMP4, CDC42, WNT6

GO:0060686

BP

negative regulation of prostatic bud formation

Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth.

BMP4, WNT5A, SULF1

GO:0060687

BP

regulation of branching involved in prostate gland morphogenesis

Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.

ESR1, BMP4, FGFR2, SFRP1

GO:0060688

BP

regulation of morphogenesis of a branching structure

Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.

FGFR2, PGF

GO:0060689

BP

cell differentiation involved in salivary gland development

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland.

NFIB

GO:0060691

BP

epithelial cell maturation involved in salivary gland development

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state.

XBP1

GO:0060693

BP

regulation of branching involved in salivary gland morphogenesis

Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium.

SNAI2, TNF

GO:0060694

BP

regulation of cholesterol transporter activity

Any process that modulates the rate, frequency, or extent of cholesterol transporter activity.

PPARG

GO:0060695

BP

negative regulation of cholesterol transporter activity

Any process that decreases the rate, frequency, or extent of cholesterol transporter activity.

APOA2

GO:0060696

BP

regulation of phospholipid catabolic process

Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.

IDH1

GO:0060698

MF

endoribonuclease inhibitor activity

Stops, prevents or reduces the activity of an endoribonuclease, any enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

ABCE1

GO:0060699

BP

regulation of endoribonuclease activity

Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

NPM1

GO:0060702

BP

negative regulation of endoribonuclease activity

Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

ABCE1

GO:0060706

BP

cell differentiation involved in embryonic placenta development

The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta.

KRT8, KRT19, STK4

GO:0060707

BP

trophoblast giant cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua.

E2F8, PLK4, SOCS3, LIF, NR2F2, MDFI

GO:0060708

BP

spongiotrophoblast differentiation

The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell.

SOCS3, LIF

GO:0060709

BP

glycogen cell differentiation involved in embryonic placenta development

The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer.

AKT1

GO:0060710

BP

chorio-allantoic fusion

The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois.

CYR61, DNAJB6, ZFP36L1

GO:0060711

BP

labyrinthine layer development

The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state.

MAP2K1, GAB1, CITED1

GO:0060712

BP

spongiotrophoblast layer development

The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state.

ADM, ZFP36L1, CITED1

GO:0060713

BP

labyrinthine layer morphogenesis

The process in which the labyrinthine layer of the placenta is generated and organized.

NCOA1

GO:0060715

BP

syncytiotrophoblast cell differentiation involved in labyrinthine layer development

The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta.

DNAJB6, CASP8

GO:0060716

BP

labyrinthine layer blood vessel development

The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.

CYR61, HS6ST1, WNT2, JUNB, MAPK1, AKT1, PLCD1, HES1, TMED2, NSDHL, HEY1

GO:0060717

BP

chorion development

The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane.

DNAJB6

GO:0060718

BP

chorionic trophoblast cell differentiation

The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.

E2F8, HTRA1, MAP3K4

GO:0060721

BP

regulation of spongiotrophoblast cell proliferation

Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation.

NRK

GO:0060729

BP

intestinal epithelial structure maintenance

A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.

TLR4, SOX9

GO:0060731

BP

positive regulation of intestinal epithelial structure maintenance

Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.

SLC22A5

GO:0060732

BP

positive regulation of inositol phosphate biosynthetic process

Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.

PTAFR, SNCA, ADCYAP1R1, CD244

GO:0060733

BP

regulation of eIF2 alpha phosphorylation by amino acid starvation

Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.

EIF2AK4, IMPACT

GO:0060734

BP

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress.

PPP1R15A

GO:0060735

BP

regulation of eIF2 alpha phosphorylation by dsRNA

Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA.

NPM1

GO:0060736

BP

prostate gland growth

The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state.

PSAP, AR, CYP19A1, PRLR, PTEN, PLAG1

GO:0060739

BP

mesenchymal-epithelial cell signaling involved in prostate gland development

Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time.

TNC

GO:0060740

BP

prostate gland epithelium morphogenesis

The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.

AR, TNC, NOTCH1, ID4

GO:0060741

BP

prostate gland stromal morphogenesis

The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland.

ID4

GO:0060742

BP

epithelial cell differentiation involved in prostate gland development

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland.

PSAP, AR, CTNNB1

GO:0060743

BP

epithelial cell maturation involved in prostate gland development

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

FEM1B

GO:0060744

BP

mammary gland branching involved in thelarche

The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.

TGFB1, AREG, WNT5A, PHB2

GO:0060745

BP

mammary gland branching involved in pregnancy

The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy.

ESR1, VDR

GO:0060748

BP

tertiary branching involved in mammary gland duct morphogenesis

The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy.

AR

GO:0060749

BP

mammary gland alveolus development

The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.

TNFSF11, ESR1, AR, AREG, VEGFA, PRLR, ID2, DDR1, ERBB4, PHB2, TNFRSF11A

GO:0060750

BP

epithelial cell proliferation involved in mammary gland duct elongation

The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth.

ESR1, AREG, WNT5A

GO:0060751

BP

branch elongation involved in mammary gland duct branching

The developmental growth process in which a branch of a mammary gland duct elongates.

TGFB1

GO:0060753

BP

regulation of mast cell chemotaxis

Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus.

RAC2

GO:0060754

BP

positive regulation of mast cell chemotaxis

Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus.

PGF, VEGFC

GO:0060760

BP

positive regulation of response to cytokine stimulus

Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.

WNT5A

GO:0060761

BP

negative regulation of response to cytokine stimulus

Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus.

KLF4, APOA1, AES, MAP2K5, MAPK7

GO:0060762

BP

regulation of branching involved in mammary gland duct morphogenesis

Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis.

TGFB1, ETV5, WNT5A, PHB2

GO:0060763

BP

mammary duct terminal end bud growth

The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty.

KDM5B

GO:0060764

BP

cell-cell signaling involved in mammary gland development

Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure.

LRP5

GO:0060765

BP

regulation of androgen receptor signaling pathway

Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.

DDX5, EP300, HDAC6, RNF14, RNF6

GO:0060766

BP

negative regulation of androgen receptor signaling pathway

Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.

TCF21, PHB, SMARCA4, DAB2, HDAC1, SFRP1, FOXP1, HEYL

GO:0060768

BP

regulation of epithelial cell proliferation involved in prostate gland development

Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.

NOTCH1

GO:0060769

BP

positive regulation of epithelial cell proliferation involved in prostate gland development

Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.

CTNNB1

GO:0060770

BP

negative regulation of epithelial cell proliferation involved in prostate gland development

Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.

SERPINF1, CDKN1B, STK11

GO:0060775

BP

planar cell polarity pathway involved in gastrula mediolateral intercalation

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation.

WNT5A

GO:0060784

BP

regulation of cell proliferation involved in tissue homeostasis

Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue.

SOX9

GO:0060789

BP

hair follicle placode formation

The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.

CTNNB1, CDC42, GNAS, HDAC1, GNAS, HDAC2

GO:0060800

BP

regulation of cell differentiation involved in embryonic placenta development

Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state.

STK4

GO:0060804

BP

positive regulation of Wnt signaling pathway by BMP signaling pathway

A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a Wnt signaling pathway.

BMP2

GO:0060807

BP

regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that ultimately results in a cell being specified to adopt a definitive endodermal cell fate.

SOX17

GO:0060809

BP

mesodermal to mesenchymal transition involved in gastrulation

The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation.

WNT5A

GO:0060816

BP

random inactivation of X chromosome

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex.

RLIM

GO:0060821

BP

inactivation of X chromosome by DNA methylation

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by a mechanism of DNA methylation.

SMCHD1

GO:0060823

BP

canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the formation of the neural plate anterior/posterior pattern.

AXIN1

GO:0060828

BP

regulation of canonical Wnt signaling pathway

Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

PARK2, LRP5, FOLR1, EMD, PPP1CA, KREMEN1, MKS1, ANKRD10, BTRC

GO:0060830

BP

ciliary receptor clustering involved in smoothened signaling pathway

Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway.

SSNA1, IFT122

GO:0060831

BP

smoothened signaling pathway involved in dorsal/ventral neural tube patterning

The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube.

TULP3, GLI2, GLI3, PTCH1, IFT122

GO:0060836

BP

lymphatic endothelial cell differentiation

The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels.

ACVR2B, BMPR2, PROX1

GO:0060837

BP

blood vessel endothelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels.

CCM2

GO:0060840

BP

artery development

The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.

GLI3, HOXA1, ACVR2B, BMPR2

GO:0060841

BP

venous blood vessel development

The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.

ACVR2B, BMPR2

Showing 10,101–10,200 of 13,237