GO:0060217

BP

hemangioblast cell differentiation

The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages.

TAL1

GO:0060218

BP

hematopoietic stem cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

CHD2, ACE, XRCC5, TAL1, ERCC2, MEOX1, CDK6, SFRP1

GO:0060219

BP

camera-type eye photoreceptor cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye.

SDK2

GO:0060221

BP

retinal rod cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.

SOX9, SOX8

GO:0060228

MF

phosphatidylcholine-sterol O-acyltransferase activator activity

Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines.

APOA1, APOE, APOA2, APOC1, APOA5

GO:0060229

MF

lipase activator activity

Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.

APOA5

GO:0060230

MF

lipoprotein lipase activator activity

Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein.

APOH, APOA5

GO:0060231

BP

mesenchymal to epithelial transition

A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.

FZD7, WT1, TCF15, CITED1

GO:0060235

BP

lens induction in camera-type eye

Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens.

BMP4, HIPK2

GO:0060236

BP

regulation of mitotic spindle organization

Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

PKD1, PSRC1, BORA, TPX2, TACC3

GO:0060242

BP

contact inhibition

The cellular process in which cells stop growing or dividing in response to increased cell density.

TSPO, YAP1, PTPRJ

GO:0060243

BP

negative regulation of cell growth involved in contact inhibition

The negative regulation of cell growth in response to increased cell density.

CDHR2

GO:0060244

BP

negative regulation of cell proliferation involved in contact inhibition

Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density.

DACH1

GO:0060251

BP

regulation of glial cell proliferation

Any process that modulates the frequency, rate or extent of glial cell proliferation.

CREB1

GO:0060252

BP

positive regulation of glial cell proliferation

Any process that activates or increases the rate or extent of glial cell proliferation.

LYN, TSPO, ETV5, PRKCI, PLAG1

GO:0060253

BP

negative regulation of glial cell proliferation

Any process that stops or decreases the rate or extent of glial cell proliferation.

TSPO, NOTCH1, HES1

GO:0060259

BP

regulation of feeding behavior

Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.

AGRP, CNR1, STAT3, LEPR, EIF2AK4

GO:0060261

BP

positive regulation of transcription initiation from RNA polymerase II promoter

Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.

GTF2F2, HNF1A

GO:0060263

BP

regulation of respiratory burst

Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.

RAC2, RAC1, NOXA1

GO:0060266

BP

negative regulation of respiratory burst involved in inflammatory response

Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.

INS, DUSP10

GO:0060267

BP

positive regulation of respiratory burst

Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.

INS, INSR, CAMK1D

GO:0060271

BP

cilium morphogenesis

A process that is carried out at the cellular level and in which the structure of a cilium is organized.

PTPDC1, UNC119B, C21orf2, OFD1, TROVE2, NOTCH1, ACTR3, SEPT7, TCTN3, NPHP3, BBS7, AHI1, IQUB, IFT43, C5orf30, TCTN2, BBS2, IFT122, MKKS, PARVA, MKS1, CC2D2A, ASAP1, B9D1, KIF3A

GO:0060272

BP

embryonic skeletal joint morphogenesis

The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton.

AXIN1, SHOX2, BMP4, OSR1

GO:0060279

BP

positive regulation of ovulation

Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.

INHBA, INHBB

GO:0060282

BP

positive regulation of oocyte development

Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.

PDE5A, PDE3A

GO:0060283

BP

negative regulation of oocyte development

Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.

IGF1

GO:0060285

BP

cilium-dependent cell motility

Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.

DRC1, DNAAF2, DNAH1

GO:0060287

BP

epithelial cilium movement involved in determination of left/right asymmetry

The movement of cilia of epithelial cells resulting in the transport of signals which determine asymmetry in an organism's body plan with respect to the left and right halves.

OFD1, NPHP3, CCDC103

GO:0060290

BP

transdifferentiation

The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.

GATA4, SMAD3, INSM1, MEF2C

GO:0060291

BP

long-term synaptic potentiation

A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.

S100B, SERPINE2, MAPK1, SNCA, PTEN, SNAP25, VAMP2, STX4, GRIN2A, STX3, ITPR3, NTRK2, NLGN1, TNR, PLK2

GO:0060292

BP

long term synaptic depression

A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.

PTEN, STXBP1, ARF1, ABHD6, PLK2

GO:0060294

BP

cilium movement involved in cell motility

Movement of cilia mediated by motor proteins that contributes to the movement of a cell.

CFAP46, DNAH1

GO:0060296

BP

regulation of cilium beat frequency involved in ciliary motility

Any process that modulates the frequency of cilium beating involved in ciliary motility.

BBS2, MKKS

GO:0060297

BP

regulation of sarcomere organization

Any process that modulates the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

MEF2C, AKAP13

GO:0060298

BP

positive regulation of sarcomere organization

Any process that increases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

BMP10, EDN1, PROX1

GO:0060300

BP

regulation of cytokine activity

Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.

GREM2

GO:0060301

BP

positive regulation of cytokine activity

Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.

NRP1

GO:0060302

BP

negative regulation of cytokine activity

Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.

IL10

GO:0060306

BP

regulation of membrane repolarization

Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative.

YWHAE, KCNH2, AKAP6, NEDD4L

GO:0060307

BP

regulation of ventricular cardiac muscle cell membrane repolarization

Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.

WDR1, GJA1, GJA5, CACNA2D1, ANK2, KCNH2, SNTA1

GO:0060311

BP

negative regulation of elastin catabolic process

Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.

CST3

GO:0060312

BP

regulation of blood vessel remodeling

Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels.

TGFB1, FLT4

GO:0060313

BP

negative regulation of blood vessel remodeling

Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels.

CST3, BCR, ABR

GO:0060314

BP

regulation of ryanodine-sensitive calcium-release channel activity

Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.

DMD, PRKACA, PLN, PDE4D, CAMK2D, JSRP1, SEPN1

GO:0060315

BP

negative regulation of ryanodine-sensitive calcium-release channel activity

Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.

GSTM2, SRI, CALM2, GSTO1, PKD2

GO:0060316

BP

positive regulation of ryanodine-sensitive calcium-release channel activity

Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.

GSTM2, CALM2, GSTO1, AKAP6

GO:0060317

BP

cardiac epithelial to mesenchymal transition

A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

WNT2, BMP2, TGFBR1, NOTCH1, TGFB2, TGFBR3, OLFM1, HEYL, RTN4, HEY1

GO:0060318

BP

definitive erythrocyte differentiation

Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis.

TGFBR3

GO:0060319

BP

primitive erythrocyte differentiation

Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis.

VEGFA

GO:0060322

BP

head development

The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.

EDNRA, TRABD2A, MKS1, FLRT3

GO:0060323

BP

head morphogenesis

The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body.

WNT3, SSBP3

GO:0060324

BP

face development

The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.

ZFAND5, ALDH1A2, RAF1, MAPK3, MAPK1, WNT5A, ALDH1A3, MAP2K1, MKKS, CHD7

GO:0060325

BP

face morphogenesis

The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.

TBX1, LRP6, DKK1, TGFB1, COL1A1, MMP2, RRAS, SKI, DLX5, TGFB2, PTPN11, ARID5B, RAB3GAP1, NIPBL, ANKRD11, CSRNP1, CRISPLD2, CRISPLD1

GO:0060326

BP

cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

GPR32, CXCL14, PDGFB, CXCL1, PDGFRB, SAA2, KIT, HGF, PDGFRA, VCAM1, CXCL2, FPR1, C5AR1, FPR2, HMGB2, AGTR1, CXCL5, CXCL12, EPHB1, CCL20, CXCL6, PRKCQ, PRKCD, SEMA5A, ARHGEF16, HBEGF, BIN2

GO:0060333

BP

interferon-gamma-mediated signaling pathway

A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.

TRIM38, IRF6, MID1, JAK2, HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, MT2A, ICAM1, IRF1, FCGR1A, NCAM1, HLA-E, HLA-DRB4, IFNGR1, CD44, HLA-G, VCAM1, HLA-DPA1, JAK1, SP100, PTAFR, HLA-A, HLA-F, GBP1, GBP2, IFNGR2, B2M, HLA-DRB3, IRF9, PRKCD, TRIM26, NMI, CAMK2D, TRIM25, HLA-DRB5, TRIM22, FCGR1B, TRIM62, TRIM34, TRIM8

GO:0060334

BP

regulation of interferon-gamma-mediated signaling pathway

Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.

SOCS3, SOCS1, JAK2, HSP90AB1, IFNGR1, PTPN2, JAK1, IFNGR2, CDC37

GO:0060335

BP

positive regulation of interferon-gamma-mediated signaling pathway

Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.

NLRC5

GO:0060336

BP

negative regulation of interferon-gamma-mediated signaling pathway

Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.

PTPN2, PPARG, NR1H2, NR1H3

GO:0060337

BP

type I interferon signaling pathway

A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

IRF6, IFNA1 , HLA-B, IFNA16, ISG15, IRF1, IFITM1, HLA-E, IFNAR1, HLA-G, EGR1, JAK1, SP100, PSMB8, HLA-A, HLA-F, GBP2, IFI27, IFNAR2, STAT2, IRF9, IFITM3, RNASEL, BST2, XAF1, ISG20, IP6K2, SAMHD1

GO:0060338

BP

regulation of type I interferon-mediated signaling pathway

Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.

IFNA1 , IFNA16, HSP90AB1, IFNAR1, JAK1, IFNAR2, STAT2, PTPN11, CDC37

GO:0060339

BP

negative regulation of type I interferon-mediated signaling pathway

Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.

PTPN2, NLRC5

GO:0060340

BP

positive regulation of type I interferon-mediated signaling pathway

Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.

WNT5A, FADD, MAVS, NLRC5, LSM14A, TRIM6

GO:0060341

BP

regulation of cellular localization

Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.

CAMK2D, PARD3

GO:0060345

BP

spleen trabecula formation

The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.

SLC40A1

GO:0060346

BP

bone trabecula formation

The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod.

COL1A1, MMP2, FBN2, PPARGC1B, SFRP1

GO:0060347

BP

heart trabecula formation

The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.

BMP10, RBP4, TEK, TGFBR3, ADAMTS1, HEY1

GO:0060348

BP

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

SH3PXD2B, SMAD9, TULP3, PAPSS2, WHSC1, BGLAP, SPARC, HSD17B1, SRD5A1, NPR2, FGFR2, PPIB, SRD5A2, PTGER4, STC1, GNAS, AKAP13, SMAD1, GNAS, ANKRD11, SULF2, SULF1, BBX, SMAD5, VKORC1, SLC38A10, PDGFC

GO:0060349

BP

bone morphogenesis

The process in which bones are generated and organized.

LRP5, DHRS3, SKI, FGFR2, CHSY1, HAS2, GLG1, CYP26B1

GO:0060350

BP

endochondral bone morphogenesis

The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.

BMPR2, CARM1

GO:0060351

BP

cartilage development involved in endochondral bone morphogenesis

The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.

SHOX2, COL1A1

GO:0060354

BP

negative regulation of cell adhesion molecule production

Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.

APOA1

GO:0060355

BP

positive regulation of cell adhesion molecule production

Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.

FLOT1, IL1B, CAV1, COLEC12

GO:0060356

BP

leucine import

The directed movement of leucine into a cell or organelle.

SLC3A2

GO:0060359

BP

response to ammonium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.

ADSS

GO:0060363

BP

cranial suture morphogenesis

The process in which any suture between cranial bones is generated and organized.

INSIG1, BMP4, TWIST1

GO:0060364

BP

frontal suture morphogenesis

The process in which the frontal suture is generated and organized.

TGFB1, GLI3

GO:0060366

BP

lambdoid suture morphogenesis

The process in which the lambdoid suture is generated and organized.

GLI3

GO:0060367

BP

sagittal suture morphogenesis

The process in which the sagittal suture is generated and organized.

GLI3

GO:0060368

BP

regulation of Fc receptor mediated stimulatory signaling pathway

Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.

PLSCR1, CSK, RABGEF1

GO:0060369

BP

positive regulation of Fc receptor mediated stimulatory signaling pathway

Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.

LYN

GO:0060370

BP

susceptibility to T cell mediated cytotoxicity

The process of causing a cell to become susceptible to T cell mediated cytotoxicity.

PVR

GO:0060371

BP

regulation of atrial cardiac muscle cell membrane depolarization

Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte.

CACNA1G, GJA1, GJA5

GO:0060373

BP

regulation of ventricular cardiac muscle cell membrane depolarization

Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte.

SMAD7, GJA1, GJA5

GO:0060374

BP

mast cell differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.

PIK3CD, KIT

GO:0060375

BP

regulation of mast cell differentiation

Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.

TAL1

GO:0060379

BP

cardiac muscle cell myoblast differentiation

The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.

NRG1

GO:0060381

BP

positive regulation of single-stranded telomeric DNA binding

Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding.

ACD

GO:0060382

BP

regulation of DNA strand elongation

Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand.

NUCKS1

GO:0060383

BP

positive regulation of DNA strand elongation

Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand.

POT1

GO:0060384

BP

innervation

The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.

LRIG2, SERPINE2, GABRA5, RNF165, SULF2, SULF1, LRIG1, CHD7

GO:0060385

BP

axonogenesis involved in innervation

The neurite development process that generates a long process of a neuron, as it invades a target tissue.

NRP1, NTRK1, SEMA3A

GO:0060386

BP

synapse assembly involved in innervation

The assembly of a synapse within a target tissue in which a nerve is invading.

FBXO45

GO:0060389

BP

pathway-restricted SMAD protein phosphorylation

The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor.

SMAD7, BMP10, TGFB1, BMP2, TGFBR1, TGFBR2, TGFB2, TGFBR3, ACVR1, USP15

GO:0060390

BP

regulation of SMAD protein import into nucleus

Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

TGFB1

GO:0060391

BP

positive regulation of SMAD protein import into nucleus

Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

TGFB1, PARP1, BMP4, BMP6, BMPR1A, TGFBR1, DAB2, SMAD4, NUP93, RBPMS

GO:0060392

BP

negative regulation of SMAD protein import into nucleus

Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

PBLD

GO:0060393

BP

regulation of pathway-restricted SMAD protein phosphorylation

Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

BMP4, BMPER

GO:0060394

BP

negative regulation of pathway-restricted SMAD protein phosphorylation

Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

SMAD7, SMAD6, GREM1, DKK1, PBLD, PMEPA1

GO:0060395

BP

SMAD protein signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.

SLC33A1, MSTN, SMAD9, GDF9, GDF11, BMP10, BMP15, FOS, TGFB1, INHA, JUN, INHBA, VIM, INHBB, BMP2, BMP4, BMP3, SKI, BMP1, BMP6, BMP8B, GDF5, SUB1, INHBC, TGFB2, SMAD3, SMAD4, SMAD2, SMAD1, BMP8A, MAGI2, NUP93, ATOH8, SMAD5, CITED1, GDF15, HIPK2, LNPEP

GO:0060396

BP

growth hormone receptor signaling pathway

The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.

SOCS2, JAK2, GH1, GHR, PIK3R1, STAT3, PTK2