| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0005018 | MF | platelet-derived growth factor alpha-receptor activity | Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity. |
PDGFRA |
GO:0005019 | MF | platelet-derived growth factor beta-receptor activity | Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity. |
PDGFRB |
GO:0005020 | MF | stem cell factor receptor activity | Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
KIT |
GO:0005021 | MF | vascular endothelial growth factor-activated receptor activity | Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
NRP1, NRP2, PDGFRA, FLT4 |
GO:0005024 | MF | transforming growth factor beta-activated receptor activity | Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
TGFBR1, TGFBR2, TGFBR3, LTBP1 |
GO:0005025 | MF | transforming growth factor beta receptor activity, type I | Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals. |
TGFBR1, ACVR1 |
GO:0005026 | MF | transforming growth factor beta receptor activity, type II | Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor. |
TGFBR2, AMHR2 |
GO:0005031 | MF | tumor necrosis factor-activated receptor activity | Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. |
TNFRSF11B, TNFRSF10C, TNFRSF21, NGFR, TNFRSF1B, FAS, CD27, TNFRSF8, LTBR, TNFRSF25, TNFRSF19, TNFRSF11A |
GO:0005034 | MF | osmosensor activity | Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell. |
TRPV4 |
GO:0005041 | MF | low-density lipoprotein receptor activity | Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis. |
LRP6, LDLR, CD36, OLR1, VLDLR, LRP2, LRP10, STAB2, CXCL16, STAB1 |
GO:0005042 | MF | netrin receptor activity | Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
UNC5C |
GO:0005044 | MF | scavenger receptor activity | Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). |
ENPP3, CD5L, VTN, CFI, ENPP1, CD6, PRSS12, ENPP2, SCARF1, COLEC12, CD163, SBSPON, STAB2, PRG4, LOXL4, TINAGL1, CXCL16, ACKR4, CD163L1, STAB1, DMBT1, LOXL2 |
GO:0005046 | MF | KDEL sequence binding | Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. |
KDELR1 |
GO:0005047 | MF | signal recognition particle binding | Interacting selectively and non-covalently with the signal recognition particle. |
SRP72, SRP9, SRPRB |
GO:0005048 | MF | signal sequence binding | Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. |
AP2B1, AP2M1 |
GO:0005049 | MF | nuclear export signal receptor activity | Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm. |
XPO1, NUPL2, CSE1L, XPO4 |
GO:0005055 | MF | laminin receptor activity | Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. |
RPSA, BCAM |
GO:0005057 | MF | receptor signaling protein activity | Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. |
RGS12, DCLK1, FLRT2, TYROBP, ADRB1, FCGR1A, IFITM1, IL4R, TGFBR1, PIP4K2B, ARF1, IL1RL1, TIAM1, PDCL, SMAD1, NSMAF, DOK1, SMAD5, FLRT3, FLRT1, DOK5 |
GO:0005068 | MF | transmembrane receptor protein tyrosine kinase adaptor activity | The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. |
PIK3R1, IRS1, FRS2, BLNK, PAG1 |
GO:0005070 | MF | SH3/SH2 adaptor activity | Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). |
SOCS2, IRS4, ARHGAP6, SKAP2, CD28, CHN1, CRKL, SH3BGR, GRB2, PTPN11, KHDRBS1, EPS8, GRB10, GAB1, TP53BP2, GRB14, SHB, BLNK, STAM, SORBS1, PAG1, ITSN2, VAV3 |
GO:0005072 | MF | transforming growth factor beta receptor, cytoplasmic mediator activity | Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus. |
CDKN1B |
GO:0005078 | MF | MAP-kinase scaffold activity | The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently. |
SPAG9, AKAP13, MAPK8IP2, DUSP19, MAPK8IP3, MAPK8IP1 |
GO:0005080 | MF | protein kinase C binding | Interacting selectively and non-covalently with protein kinase C. |
LDB3, HSPB1, PRKCB, ITGAV, TOP2A, PRKCSH, DSP, MARCKS, SDC4, AKT1, GRK5, IRS1, HINT1, TIRAP, RACK1, SRSF2, C1QBP, ADAM9, SQSTM1, TDG, PKN1, TWF2, HDAC7, PRKCDBP, DACT3, PDLIM5, FEZ1, PKP2, TRPV4, PARD6A, DACT1, HDAC9, HDAC5 |
GO:0005085 | MF | guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
BCAR3, PLEKHG5, VAV1, SOS1, SOS2, ARHGEF5, AKAP13, RALGDS, ABR, TIAM1, EIF2B5, ARHGEF7, EIF2B1, RAB3GAP1, ITSN1, RALGPS1, ARHGEF16, LAMTOR1, FGD6, RASGRP2, NET1, FGD2, RALGPS2, TAGAP, ARHGEF28, DOCK8, FLCN, RAPGEF6, FNIP1, RAPGEF4, GBF1, ELMO1, RPGR, HPS1, ARHGEF2, DOCK10, DOCK6, FGD4, DOCK7, SPATA13, ANKRD27, ALS2, DOCK5, PLEKHG2, ECT2, RANGRF, HPS4, EIF2B3, ARHGEF4, ARHGEF3, LAMTOR3, EIF2B4, VAV3, DIS3, LAMTOR2, ARFGEF2 |
GO:0005086 | MF | ARF guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
CYTH3, ARF4, TRIP10, FNBP1L, ARFGEF3, IQSEC1, GBF1, FNBP1, FBXO8, PSD3, ARFGEF2 |
GO:0005087 | MF | Ran guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
RCC1, ALS2, RANGRF |
GO:0005088 | MF | Ras guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
EREG, JAK2, FGF18, FGF19, EGFR, PDGFB, PDGFA, ERBB2, FYN, ADRB1, FGF2, PDGFRB, KIT, FGFR1, NCAM1, PDGFRA, KITLG, FGF7, FGFR2, ERBB3, JAK1, FGF9, BTC, IRS1, ACTN2, JAK3, CALM2, GRB2, DLG4, SHC2, SPTBN1, IL5RA, NRG1, TEK, PTK2, SOS1, GRIN2A, CAMK2D, ERBB4, ANGPT1, KNDC1, FRS2, RAPGEF4, HBEGF, SPTBN4, KL, IRS2 |
GO:0005089 | MF | Rho guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
ARHGEF10, PLEKHG5, FARP2, BCR, VAV1, SOS1, SOS2, ARHGEF5, AKAP13, ABR, TIAM1, ARHGEF7, ITSN1, DOCK11, ARHGEF16, DNMBP, FGD6, NET1, FGD2, MCF2L2, ARHGEF28, ARHGEF39, ARHGEF2, ARHGEF26, FGD4, PLEKHG2, ECT2, ARHGEF10L, ARHGEF4, ARHGEF3, ITSN2, VAV3, FARP1 |
GO:0005092 | MF | GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. |
ITGB1BP1, CHM, CHML, GDI1, RANBP1, SESN2, GPSM2, GPSM1, SH3BP4 |
GO:0005093 | MF | Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
GDI1, GDI2 |
GO:0005094 | MF | Rho GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. |
ARHGDIA, ARHGDIB |
GO:0005095 | MF | GTPase inhibitor activity | Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. |
IPO5, PDE6D, SLIT2, IQGAP1, TNK2, GPS2, IQGAP2, CPEB2, CDC42SE1 |
GO:0005096 | MF | GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
TBC1D3D, TBC1D3E, TBC1D3F, ARHGAP42, ARHGAP33, RGS12, AXIN1, RGS5, ASAP2, ARHGAP6, RASA4, RGS10, TBC1D4, TBC1D12, ADAP1, RP2, FAM13A, TBC1D8, ALDH1A1, A2M, JUN, TBC1D3H, BCR, CHN1, RASA1, CHM, CHML, GDI1, RGS2, HTR2B, ARHGAP25, RANBP1, RANGAP1, IQGAP1, RGS3, RGS4, RGS7, TSC2, GNAQ, GDI2, RAP1GDS1, ARHGDIA, ARHGDIB, AGFG1, OCRL, SOS1, TBC1D8B, ABR, NPRL3, ARHGAP5, MYO9B, GIT2, RASA3, ARHGAP19, RAB3GAP1, ACAP2, RABEP1, RASA2, RALBP1, TRIP10, ARHGAP31, RALGAPA2, ARHGAP29, RABGAP1L, STXBP5, ARHGAP21, DEPDC1, GRTP1, TBC1D9B, RALGAPA1, TBC1D3C, ARHGAP11A, TBC1D9, SYDE1, PREX2, ARHGAP22, SRGAP1, ARHGAP30, RALGAPB, TBC1D3, TAGAP, ARHGAP24, ARHGAP18, TBC1D19, ARFGAP2, RGS22, RIN3, TBC1D16, TBC1D15, DEPDC1B, ARAP3, RIN2, ARAP2, STARD8, DOCK2, TBC1D5, USP6NL, RUNDC1, EVI5L, ANKRD27, ARAP1, AGAP4, SYNGAP1, DLC1, TBCD, RACGAP1, SH3BGRL3, RAB3GAP2, ECT2, ARFGAP3, ADAP2, PLCB1, FAM13B, HACD3, ARHGAP23, ARHGAP20, SIPA1L2, TBC1D14, ERRFI1, CDC42EP3, VAV3, ASAP1, ARHGAP26, AGAP1, TBC1D2B, VPS9D1, STXBP5L, GIT1, STARD13, RABGAP1 |
GO:0005102 | MF | receptor binding | Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
NUDT19, MYO1C, AGRP, ADAM10, ACOT8, MSTN, SLC27A2, FYB, ANGPT2, GNPAT, LEPROT, ACOX3, MTSS1, RIPK2, TRAF3IP2, ENSA, TYROBP, TRAK2, PLXNC1, JAK2, SRPX2, CTNND1, DIAPH2, PEX14, ECI2, LRP6, IDH1, TNFSF13, NXPH3, ABCA1, EML2, ANGPTL1, F2, PLG, PLAT, A2M, C3, KNG1, POMC, LHB, GCG, FGA, FGB, FGG, ANG, AMH, ANXA1, APP, INHA, SERPINE1, LPL, SERPINE2, PFN1, LYN, IGFBP1, CXCL1, PDGFRB, NUDT7, HSPA1A, HSPA1B, AR, IAPP, MBL2, BMP2, BMP3, TDGF1, CCL2, HLA-E, MIF, IDE, LIF, PVR, NPPB, GJA1, HLA-G, IGFBP2, CD58, EFNA1, MAG, RASA1, AGXT, SCP2, IGFBP4, JAK1, PTPRD, TNFSF4, LAMA2, IGFBP6, F2R, ITGB8, DPP4, GSTM2, SSFA2, EPHB2, HLA-F, LRPAP1, SRI, CDH5, ADM, HMGCL, CD200, CSK, NSG1, CRAT, CXCL12, NMU, TNFSF10, INSL3, HSD17B4, JAK3, F2RL1, ARPP19, NXPH1, TGFB2, RACK1, CAV1, PLAUR, PTK2, SMAGP, ECH1, PKD2, ALCAM, SELPLG, MAP7, GAS6, ACOX1, NECTIN1, PPP2R4, ADIPOQ, LAMA4, LAMA3, HFE, WIPI1, CD276, STYK1, SMARCD3, VTCN1, LONP2, ACOT4, DDX54, UFD1L, GLG1, RAB8B, SMARCD1, PANX1, ACOX2, P2RX4, RARRES2, APOL2, CNPY3, DHRS4, RSPO3, CADM1, WNT5B, FZD8, NECTIN3, HAO2, PIPOX, CLCF1, CROT, APLN, TNFSF13B, GSTK1, HILPDA |
GO:0005104 | MF | fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). |
FLRT2, FGF19, FGF2, FGF7, FGF9, FRS2, FLRT3, FLRT1, KL |
GO:0005105 | MF | type 1 fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1). |
FGF18 |
GO:0005109 | MF | frizzled binding | Interacting selectively and non-covalently with the frizzled (fz) receptor. |
SDCBP, FZD7, LRP6, WNT2, WNT5A, WNT3, NDP, BAMBI, SFRP1, WNT2B, CTHRC1, RSPO3, WNT5B, GOPC, WNT6 |
GO:0005110 | MF | frizzled-2 binding | Interacting selectively and non-covalently with frizzled-2 (fz2). |
WNT5A |
GO:0005111 | MF | type 2 fibroblast growth factor receptor binding | Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2). |
FGF18 |
GO:0005112 | MF | Notch binding | Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. |
NOTCH1, JAG1, ADAM17, AAK1, DNER, CHAC1, DLL4, NCOR2 |
GO:0005113 | MF | patched binding | Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins. |
DHH, CCNB1, CAV1, PTCH1, BBS1 |
GO:0005114 | MF | type II transforming growth factor beta receptor binding | Interacting selectively and non-covalently with a type II transforming growth factor beta receptor. |
TGFB1, TGFBR1, TGFB2, TGFBR3, BAMBI |
GO:0005115 | MF | receptor tyrosine kinase-like orphan receptor binding | Interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror). |
WNT5A |
GO:0005119 | MF | smoothened binding | Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals. |
PTCH1, BBS1 |
GO:0005123 | MF | death receptor binding | Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). |
CFLAR, NOL3, BID, FADD, RIPK1, CASP8, TMBIM1, FEM1B |
GO:0005125 | MF | cytokine activity | Functions to control the survival, growth, differentiation and effector function of tissues and cells. |
TNFRSF11B, TNFSF11, MSTN, GDF9, GREM1, TNFSF13, GDF11, BMP10, IL33, BMP15, TIMP1, TGFB1, TNF, IFNA1 , IL1A, IL1B, IFNA16, INHA, IL6, EDN1, GPI, INHBA, FGF2, HMGB1, INHBB, WNT2, SPP1, BMP2, BMP4, BMP3, CCL4, BMP1, SCG2, MIF, LIF, AREG, VEGFA, IL1RN, IL11, KITLG, BMP6, IL10, SP100, TNFSF4, IL32, GRN, IL12A, CD40LG, BMP8B, WNT5A, GDF5, NAMPT, TNFSF10, INHBC, TGFB2, NDP, NRG1, IL18, ADIPOQ, CTF1, IL34, BMP8A, IFNE, THNSL2, CMTM8, SECTM1, FAM3C, CMTM3, GDF15, GREM2, IL37, CLCF1, TNFSF13B |
GO:0005126 | MF | cytokine receptor binding | Interacting selectively and non-covalently with a cytokine receptor. |
MIF |
GO:0005127 | MF | ciliary neurotrophic factor receptor binding | Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor. |
IL6ST, LIFR, CLCF1 |
GO:0005131 | MF | growth hormone receptor binding | Interacting selectively and non-covalently with the growth hormone receptor. |
SOCS2, JAK2, GH1, JAK1 |
GO:0005132 | MF | type I interferon receptor binding | Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). |
IFNA1 , IFNA16, IFNE |
GO:0005134 | MF | interleukin-2 receptor binding | Interacting selectively and non-covalently with the interleukin-2 receptor. |
TIMM50 |
GO:0005136 | MF | interleukin-4 receptor binding | Interacting selectively and non-covalently with the interleukin-4 receptor. |
PIBF1 |
GO:0005137 | MF | interleukin-5 receptor binding | Interacting selectively and non-covalently with the interleukin-5 receptor. |
SDCBP |
GO:0005138 | MF | interleukin-6 receptor binding | Interacting selectively and non-covalently with the interleukin-6 receptor. |
IL6, IL6R, IL6ST, ADAM17, ERAP1, PYCARD |
GO:0005141 | MF | interleukin-10 receptor binding | Interacting selectively and non-covalently with the interleukin-10 receptor. |
IL10 |
GO:0005142 | MF | interleukin-11 receptor binding | Interacting selectively and non-covalently with the interleukin-11 receptor. |
IL11 |
GO:0005143 | MF | interleukin-12 receptor binding | Interacting selectively and non-covalently with the interleukin-12 receptor. |
JAK2, IL12A, IL12RB1 |
GO:0005146 | MF | leukemia inhibitory factor receptor binding | Interacting selectively and non-covalently with the leukemia inhibitory factor receptor. |
LIF, CTF1 |
GO:0005148 | MF | prolactin receptor binding | Interacting selectively and non-covalently with the prolactin receptor. |
PRL, GH1 |
GO:0005149 | MF | interleukin-1 receptor binding | Interacting selectively and non-covalently with the interleukin-1 receptor. |
TLR5, IL1A, IL1B, TRIP6, IL37 |
GO:0005150 | MF | interleukin-1, Type I receptor binding | Interacting selectively and non-covalently with a Type I interleukin-1 receptor. |
IL1RN, TOLLIP |
GO:0005151 | MF | interleukin-1, Type II receptor binding | Interacting selectively and non-covalently with a Type II interleukin-1 receptor. |
IL1RN, ERAP1 |
GO:0005152 | MF | interleukin-1 receptor antagonist activity | Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. |
IL1RN |
GO:0005153 | MF | interleukin-8 receptor binding | Interacting selectively and non-covalently with the interleukin-8 receptor. |
CXCL8, YARS |
GO:0005154 | MF | epidermal growth factor receptor binding | Interacting selectively and non-covalently with the epidermal growth factor receptor. |
EREG, PLSCR1, SOCS5, SNX4, TGFA, ITGA5, AREG, ARF4, BTC, GRB2, TNK2, EFEMP1, SNX1, ERBB4, HBEGF, RNF126, VAV3 |
GO:0005157 | MF | macrophage colony-stimulating factor receptor binding | Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor. |
IL34 |
GO:0005158 | MF | insulin receptor binding | Interacting selectively and non-covalently with the insulin receptor. |
IRS4, SNX4, INS, IGF2, IGF1, IGF1R, ENPP1, PIK3R1, IRS1, INSL3, PTPN11, GRB10, SNX1, FRS2, PHIP, DOK1, SORBS1, LMBRD1, DOK5, IRS2 |
GO:0005159 | MF | insulin-like growth factor receptor binding | Interacting selectively and non-covalently with the insulin-like growth factor receptor. |
SOCS2, SOCS1, INS, IGF2, IGF1, INSR, PIK3R1, IRS1, GNAS, YWHAH, GNAS |
GO:0005160 | MF | transforming growth factor beta receptor binding | Interacting selectively and non-covalently with the transforming growth factor beta receptor. |
MSTN, GDF9, GDF11, BMP10, BMP15, TGFB1, LRG1, AMH, INHA, INHBA, INHBB, BMP2, BMP4, BMP3, BMP1, BMP6, BMP8B, GDF5, INHBC, TGFB2, SMAD3, TGFBR3, SMAD2, BMP8A, GDF15, RASL11B, SMURF2, USP15 |
GO:0005161 | MF | platelet-derived growth factor receptor binding | Interacting selectively and non-covalently with the platelet-derived growth factor receptor. |
ERN1, PDGFB, PDGFA, ITGB3, LYN, ITGA5, PDGFRB, IL1R1, VEGFA, PDGFRA, PTEN, PTPRJ, PDGFD, PDGFC |
GO:0005163 | MF | nerve growth factor receptor binding | Interacting selectively and non-covalently with the nerve growth factor receptor. |
NGF |
GO:0005164 | MF | tumor necrosis factor receptor binding | Interacting selectively and non-covalently with the tumor necrosis factor receptor. |
TNFSF11, TNFSF13, TRIM37, TNF, TNFSF4, CD40LG, TNFSF10, TRAF1, FADD, CASP8, TRADD, TNFSF13B |
GO:0005166 | MF | neurotrophin p75 receptor binding | Interacting selectively and non-covalently with the neurotrophin p75 receptor. |
NTRK1, ZNF274 |
GO:0005168 | MF | neurotrophin TRKA receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKA receptor. |
PIK3R1, EFNA5, GRB2, FRS2 |
GO:0005169 | MF | neurotrophin TRKB receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKB receptor. |
BDNF, EFNA5 |
GO:0005170 | MF | neurotrophin TRKC receptor binding | Interacting selectively and non-covalently with the neurotrophin TRKC receptor. |
EFNA5 |
GO:0005171 | MF | hepatocyte growth factor receptor binding | Interacting selectively and non-covalently with the hepatocyte growth factor receptor. |
GLMN, ESM1 |
GO:0005172 | MF | vascular endothelial growth factor receptor binding | Interacting selectively and non-covalently with any vascular endothelial growth factor receptor. |
VEGFA, PGF |
GO:0005173 | MF | stem cell factor receptor binding | Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. |
KITLG, SPRED1 |
GO:0005174 | MF | CD40 receptor binding | Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes. |
CD40LG |
GO:0005175 | MF | CD27 receptor binding | Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells. |
SIVA1 |
GO:0005176 | MF | ErbB-2 class receptor binding | Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2. |
CDK5, NRG1, MUC4 |
GO:0005178 | MF | integrin binding | Interacting selectively and non-covalently with an integrin. |
CYR61, PLPP3, ADAM10, ITGB1BP1, TSPAN4, ACTN4, EDIL3, ADAM23, SEMA7A, WISP2, ECM2, WISP1, EGFR, COL3A1, FN1, VTN, VWF, IGF1, ICAM1, ITGB1, P4HB, LYN, THBS1, ITGA5, ACTN1, TIMP2, ITGA2, PTPN2, TSPAN8, VCAM1, COL5A1, CD9, TNXB, ITGA6, ITGA3, CALR, CTGF, THBS4, FBN1, ACTN2, SYK, CD151, MMP14, EMP2, CXADR, ADAM17, COL4A3, NRG1, DST, COL16A1, MFGE8, CDH17, ILK, ADAM9, GPNMB, TGFBI, S1PR3, JAM3, ESM1, ADAMTS5, ADAMTS8, NISCH, TLN1 |
GO:0005179 | MF | hormone activity | The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. |
STC2, BMP10, AGT, GNRH1, POMC, CGA, FSHB, LHB, PRL, GH1, PTH, GCG, INS, IGF2, TTR, AMH, IGF1, CHGB, INHA, EDN1, CCK, INHBA, NMB, INHBB, SCT, CGB5, CGB7, IAPP, PTHLH, NPPB, EDN2, ADM, FBN1, LEP, INSL3, STC1, COPA, INHBC, HAMP, ADIPOQ, RETN, KL, APLN |
GO:0005183 | MF | gonadotropin hormone-releasing hormone activity | The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. |
GNRH1 |
GO:0005184 | MF | neuropeptide hormone activity | The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. |
AGRP, POMC, PENK, CCK, TRH, GAL, NTS, CARTPT, SPX |
GO:0005198 | MF | structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. |
PSMD11, CLDN4, COPE, NPHP1, CLDN3, ROCK2, MPZL1, CLDN1, CSTA, LMNA, FGA, FGB, FGG, BGLAP, ANXA1, KRT1, KRT18, KRT8, TUBB, LAMB1, KRT7, CLTA, MAP2, KRT3, NEFH, KRT13, JUP, DSP, LMNB1, LAMA2, CTNNA1, SPRR2B, GNL1, COL18A1, MATR3, MAP1B, NES, COPA, PLP1, TUBA1B, JAG1, MAP1A, COL4A3, CAV1, LMNB2, IFFO1, ASPH, MAPK8IP2, SNTA1, SNTB2, SNTB1, EIF3A, MAP7, SEPT7, LAMA3, MAP7D1, ODF2, CROCC, KRT80, TUBA1A, BVES, TUBGCP3, ISCA1, SPRR2G, KRT23, PNN, SYNC, SPAG4, CDC42SE2, CDC42SE1, SPRR3, KLHL3, COPG1, LAMC3 |
GO:0005199 | MF | structural constituent of cell wall | The action of a molecule that contributes to the structural integrity of a cell wall. |
JUP |
GO:0005200 | MF | structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
FRMD3, HIP1, NDC80, ARPC2, ARPC3, PPL, SORBS3, SORBS2, YEATS4, TUBB4A, TUBB, VIM, KRT19, KRT16, TPM1, MAPT, DMD, NEFH, DSP, DES, TUBG1, CTNNA2, KRT9, ARPC4, ACTB, ACTR3, ACTR2, ACTG1, TUBA1B, TUBA4A, TUBB4B, SPTBN1, ANK2, KRT17, ANK3, TUBB3, TUBA3C, TUBB2A, PLS1, CCDC6, TUBA1A, TUBGCP3, BICD1, FRMD6, TUBB6, TUBB2B, SPTBN4, EPB41L4B, TUBB1, EPB41L1, EPB41L4A, ADD3, TUBE1, TUBD1, EPB41L3, TLN1 |
GO:0005201 | MF | extracellular matrix structural constituent | The action of a molecule that contributes to the structural integrity of the extracellular matrix. |
NCAN, TECTA, EFEMP2, CD4, COL1A1, COL3A1, COL5A2, LAMB1, COL1A2, MGP, COL4A2, HAPLN1, LAMC1, COL11A1, VCAN, COL5A1, BGN, FBLN1, ANOS1, COL8A2, COL5A3, FBN1, FBN2, CHI3L1, COL15A1, TFPI2, COMP, LUM, MUC5AC, FBLN2, COL4A3, MUC3A, COL14A1, MFAP5, COL4A6, LAMA4, FBN3, BCAN, TINAGL1, DSPP |
GO:0005212 | MF | structural constituent of eye lens | The action of a molecule that contributes to the structural integrity of the lens of an eye. |
CRYAB, VIM, MIP, CPOX |
GO:0005215 | MF | transporter activity | Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. |
FABP12, AP3D1, GOSR2, XPO1, ATP6V0E1, ASNA1, SLC37A4, NUP155, RASSF9, SEC14L2, KIF20A, PMP2, RBP1, IGF2R, FABP4, SYN1, ATP5J, ATP6V1C1, ATP5D, MIP, GABRA5, ABCC1, PTGDS, ATP5O, ATP5G3, FABP6, AP2S1, UCP3, LCN2, FABP5, ATP5G2, AP1B1, CDH17, TCOF1, TCIRG1, MFSD14B, SYPL2, SLC23A3, SLC51A, SLC16A10, SCARB1, AQP3, AP2M1, SEC22A, MFSD14A, NUP88, CHP1, TTPAL, TMEM245, STARD7, ABCB10, ABCF2, SLC25A13, VPS9D1, AP4S1 |
GO:0005216 | MF | ion channel activity | Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). |
KCNK3, GJC1, SCNN1G, TRPV2 |
GO:0005219 | MF | ryanodine-sensitive calcium-release channel activity | Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. |
RYR3, RYR2 |
GO:0005220 | MF | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts. |
ITPR2, ITPR3, ITPR1 |
GO:0005222 | MF | intracellular cAMP activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. |
CNGA1 |
GO:0005223 | MF | intracellular cGMP activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. |
CNGA1 |
GO:0005224 | MF | ATP-binding and phosphorylation-dependent chloride channel activity | Enables the transmembrane transfer of a chloride ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. |
CFTR |
GO:0005225 | MF | volume-sensitive anion channel activity | Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. |
LRRC8A, LRRC8C |
GO:0005227 | MF | calcium activated cation channel activity | Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
ANO6, TRPM4 |