| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0004853 | MF | uroporphyrinogen decarboxylase activity | Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. |
UROD |
GO:0004854 | MF | xanthine dehydrogenase activity | Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. |
XDH, AOX1 |
GO:0004855 | MF | xanthine oxidase activity | Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide. |
XDH |
GO:0004857 | MF | enzyme inhibitor activity | Binds to and stops, prevents or reduces the activity of an enzyme. |
PPP1R12A, SCG5, PLN, NOTCH1, FRY, CCAR2, TXNIP |
GO:0004859 | MF | phospholipase inhibitor activity | Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. |
APOC1, ANXA5, ANXA4, PDC |
GO:0004860 | MF | protein kinase inhibitor activity | Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. |
SOCS2, SOCS3, SOCS6, SOCS1, FLRT2, SH3BP5, SOCS5, NPM1, DCN, BGN, DNAJC3, SH3BP5L, PODN, RTN4RL1, LRRTM4, DUSP19, TRIB2, TRIB3, TRIB1, CHP1, TAOK3, LRRC19, FLRT3, FLRT1, MAPK8IP1 |
GO:0004861 | MF | cyclin-dependent protein serine/threonine kinase inhibitor activity | Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. |
HEXIM1, CDKN1A, CDKN2B, CDKN2C, CDKN1B, CDKN1C, KAT2B |
GO:0004862 | MF | cAMP-dependent protein kinase inhibitor activity | Stops, prevents or reduces the activity of a cAMP-dependent protein kinase. |
PRKAR1A, PRKAR2A, PRKAR2B, PKIA, PKIG |
GO:0004864 | MF | protein phosphatase inhibitor activity | Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. |
ENSA, PHACTR2, URI1, ARPP19, SET, PPP1R35, SH3RF2, PPP1R10, PPME1, CABIN1 |
GO:0004865 | MF | protein serine/threonine phosphatase inhibitor activity | Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. |
PPP1R11, PPP1R2, PPP1R1A, PPP1R14C, PPP1R14A, PPP1R14B |
GO:0004866 | MF | endopeptidase inhibitor activity | Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
SPINT2, RECK, SPINK1, C3, CST3, AHSG, SLPI, CSTB, C4A, C4B, TFPI, CAST, SPP2, WFDC2, PROL1, UCHL5 |
GO:0004867 | MF | serine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
SPINT2, PAPLN, RECK, SPINK1, SERPINC1, SERPINA1, SERPINA3, AGT, A2M, AMBP, SLPI, APP, SERPINE1, SERPINA5, SERPING1, SERPINE2, FURIN, TFPI, COL6A3, ANOS1, SERPINB3, PEBP1, SERPINB1, SERPINB5, SERPINF1, TFPI2, SERPINB4, SERPINB9, SERPINH1, APLP2, WFDC2, ITIH5, WFDC3, SERPINA12, CPAMD8, SERPINI1, WFDC1, CRIM1, SERPINB13 |
GO:0004869 | MF | cysteine-type endopeptidase inhibitor activity | Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
BIRC5, PTTG1, CST3, CSTA, KNG1, AHSG, CSTB, CST2, CAST, SERPINB3, WFDC2, CARD16, FETUB, SERPINB13 |
GO:0004871 | MF | signal transducer activity | Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
GPR89A, AIP, TRIM38, IRS4, PPP1R12A, AXIN1, RIPK2, TSPAN6, GNG7, TRIM13, PLEKHG5, DKK1, IKBKAP, GNAI2, S100A9, NGFR, GNAI3, LGALS1, HMOX1, GPR89B, IL1R1, JUP, GNB3, PLCG2, STMN1, GJA1, FST, CAPN3, FLNA, ZP3, CXCR2, CD24, FAS, EEF1D, GNA11, LSP1, CTNNB1, IRS1, CHKA, STAT3, STAT5A, CRKL, MAPKAPK2, RGS7, GNAQ, GNG4, PLCD1, STAT5B, STAT2, YARS, GNG11, GNB1, GNB2, GNAI1, GNG5, GNAS, ATP2C1, GNA12, PTK2, PLCXD2, BST2, AKAP13, CBLB, ITGB3BP, ILK, GAB1, PLCL1, TRADD, GNAS, WLS, PLCXD3, CSPG4, CXXC5, MAVS, TMED4, MAGI2, ZDHHC17, SLC44A2, C18orf32, SLC20A1, SECTM1, TFG, CREBBP, MIB2, LITAF, NDFIP1, TOLLIP, ECT2, SP110, NEK6, IL1RAP, PLCB1, SH2B1, NDFIP2, PLK2, VAPA, KL, PLEKHB1, CNOT7, SUFU, PLCL2, SH2B3, GOLT1B, IRS2 |
GO:0004872 | MF | receptor activity | Combining with an extracellular or intracellular messenger to initiate a change in cell activity. |
TLR4, TNFRSF11B, NPC1, TLR3, MED14, LY75, NRP2, TLR5, TLR2, RAMP1, RAMP3, LDLR, CD4, OPN1SW, KRT1, ICAM1, NGFR, CD48, IGF2R, PVR, FOLR1, CD46, CD1D, ITGB4, CD33, CHRM3, ITGAX, MRC1, FAS, ITGB8, GABRA5, CD200, ADCYAP1R1, NOTCH1, NPY2R, F2RL1, ANTXR2, FKBP3, TEK, GUCY2D, PLAUR, NOTCH2, IL10RB, SLC20A2, SMAGP, IL18R1, TLR1, MMD, SLC1A5, AMHR2, AMOT, JMJD6, SV2A, RTN4RL1, PKHD1L1, NLGN4X, NLGN1, SLC20A1, CUL5, TNFRSF25, MED12, MED30, CSF3R, SEC62, VIMP, CADM1, CD244, SLC40A1, TREM1, MED4, CD93, NECTIN3, TNFRSF19, MED17, RRBP1, SEC63, PLXNA1, AMFR, NRXN1, PROCR, SIGLEC7, THRAP3, MED16, TNPO3, LYVE1, TNFRSF11A |
GO:0004873 | MF | asialoglycoprotein receptor activity | Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane. |
LRPAP1 |
GO:0004874 | MF | aryl hydrocarbon receptor activity | Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding. |
ARNT, AHR |
GO:0004875 | MF | complement receptor activity | Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
GPR32, FPR1, FPR2 |
GO:0004877 | MF | complement component C3b receptor activity | Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
CR1 |
GO:0004878 | MF | complement component C5a receptor activity | Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
C5AR1 |
GO:0004879 | MF | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
NR5A2, AR, NR2F1, ESRRA, NR1D1, NR4A1, NR2F2, RXRB, RORA, AHR, PPARG, STAT3, NR4A2, NR0B1, NR1H2, PPARD, PPARA, NR1H3, NR1D2, GLMP, ESR2, NR1H4 |
GO:0004882 | MF | androgen receptor activity | Combining with an androgen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an androgen response element in DNA in order to modulate transcription by RNA polymerase II. |
AR |
GO:0004883 | MF | glucocorticoid receptor activity | Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function. |
NR3C1 |
GO:0004886 | MF | 9-cis retinoic acid receptor activity | Combining with 9-cis retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
RXRB |
GO:0004887 | MF | thyroid hormone receptor activity | Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
THRA, NR4A3, NR1H4 |
GO:0004888 | MF | transmembrane signaling receptor activity | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
TLR4, CLDN4, TNFRSF10C, NPC1, TLR3, CLDN3, LY75, TLR5, TLR2, LGR5, EGFR, CD4, ERBB2, ICAM1, NGFR, GP1BB, IL1R1, SELE, LAG3, ERBB3, EVI2A, MRC1, KLRC1, CD27, TNFRSF8, LEPR, CD97, BCAM, PLXNA3, SCARF1, EBP, TLR1, TRPV1, DNER, SORL1, LGR4, LGR6, INTS6, LYVE1, TNFRSF11A |
GO:0004889 | MF | acetylcholine-activated cation-selective channel activity | Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. |
CHRNB1, CHRNA5, CHRNA7 |
GO:0004890 | MF | GABA-A receptor activity | Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. |
GABRA5 |
GO:0004896 | MF | cytokine receptor activity | Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
CD74, GHR, CD44, IL12RB1, IL1RL1, CSF3R, IL17RB |
GO:0004897 | MF | ciliary neurotrophic factor receptor activity | Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL6R, IL6ST, LIFR |
GO:0004900 | MF | erythropoietin receptor activity | Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
EPOR |
GO:0004905 | MF | type I interferon receptor activity | Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. |
IFNAR1, IFNAR2 |
GO:0004906 | MF | interferon-gamma receptor activity | Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IFNGR1, IFNGR2 |
GO:0004908 | MF | interleukin-1 receptor activity | Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. |
IL1R1, IL1R2, IL1RL1, IL18R1, IL1RAP |
GO:0004909 | MF | interleukin-1, Type I, activating receptor activity | Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. |
IL1R1 |
GO:0004910 | MF | interleukin-1, Type II, blocking receptor activity | Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors. |
IL1R2 |
GO:0004913 | MF | interleukin-4 receptor activity | Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL4R |
GO:0004914 | MF | interleukin-5 receptor activity | Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL5RA |
GO:0004915 | MF | interleukin-6 receptor activity | Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL6R, IL6ST |
GO:0004917 | MF | interleukin-7 receptor activity | Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL7R |
GO:0004918 | MF | interleukin-8 receptor activity | Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
CXCR2 |
GO:0004919 | MF | interleukin-9 receptor activity | Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL9R |
GO:0004920 | MF | interleukin-10 receptor activity | Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL10RB |
GO:0004921 | MF | interleukin-11 receptor activity | Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL6ST |
GO:0004923 | MF | leukemia inhibitory factor receptor activity | Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL6ST, LIFR |
GO:0004924 | MF | oncostatin-M receptor activity | Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL6ST, LIFR, OSMR |
GO:0004925 | MF | prolactin receptor activity | Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
PRLR |
GO:0004930 | MF | G-protein coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
GRM8, GRM6, GPR37, FZD6, FZD7, GPR32, ADGRL2, IGF2R, S1PR1, C5AR1, FPR2, PTAFR, F2R, GPR183, HRH1, OPRL1, OR3A3, CD97, MTNR1B, F2RL1, CXCR4, ADGRE1, GPR176, GRM3, SFRP5, GPR158, GPR157, SFRP4, OR52E8, ADGRD1, GPR126, TPRA1, ADGRA3, SFRP1, GPRC5A, OR5A2, OR5L2, OR14C36, GPR98, GHSR, GPR146, OR2A5, S1PR3, GPER1, TM2D1, GPR63, OPN3, OR51E2, FZD8, ADGRL3, GPRC5C, GPR27, CELSR3, GPRC5B, GPR160, FZD4, GPR34, ADGRG1 |
GO:0004931 | MF | extracellular ATP-gated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts. |
P2RX4 |
GO:0004937 | MF | alpha1-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. |
ADRA1D, ADRA1A, ADRA1B |
GO:0004938 | MF | alpha2-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. |
ADRA2B |
GO:0004939 | MF | beta-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. |
ADRB1, ADRB3 |
GO:0004940 | MF | beta1-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors. |
ADRB1 |
GO:0004941 | MF | beta2-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors. |
ADRB2 |
GO:0004945 | MF | angiotensin type II receptor activity | An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. |
AGTR1, AGTR2, AGTRAP |
GO:0004948 | MF | calcitonin receptor activity | Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
RAMP1 |
GO:0004949 | MF | cannabinoid receptor activity | Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. |
CNR1 |
GO:0004950 | MF | chemokine receptor activity | Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
ACKR4 |
GO:0004951 | MF | cholecystokinin receptor activity | Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. |
CCKBR |
GO:0004955 | MF | prostaglandin receptor activity | Combining with a prostaglandin (PG) to initiate a change in cell activity. |
PPARG |
GO:0004956 | MF | prostaglandin D receptor activity | Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity. |
PTGDR |
GO:0004957 | MF | prostaglandin E receptor activity | Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. |
HPGD, PTGER4, PTGER3, PTGER2 |
GO:0004958 | MF | prostaglandin F receptor activity | Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity. |
PTGFR |
GO:0004962 | MF | endothelin receptor activity | Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
EDNRA |
GO:0004963 | MF | follicle-stimulating hormone receptor activity | Combining with follicle-stimulating hormone to initiate a change in cell activity. |
FSHR |
GO:0004964 | MF | luteinizing hormone receptor activity | Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity. |
LHCGR |
GO:0004965 | MF | G-protein coupled GABA receptor activity | Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
GABBR2, GABBR1 |
GO:0004966 | MF | galanin receptor activity | Combining with galanin to initiate a change in cell activity. |
GAL |
GO:0004968 | MF | gonadotropin-releasing hormone receptor activity | Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. |
GNRHR |
GO:0004969 | MF | histamine receptor activity | Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
HRH1, HRH3 |
GO:0004970 | MF | ionotropic glutamate receptor activity | Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. |
GRIA4 |
GO:0004971 | MF | AMPA glutamate receptor activity | An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium. |
GRIA4 |
GO:0004972 | MF | NMDA glutamate receptor activity | An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate. |
GRIN2A |
GO:0004977 | MF | melanocortin receptor activity | Combining with melanocortin to initiate a change in cell activity. |
MC4R, MC2R |
GO:0004978 | MF | corticotropin receptor activity | Combining with corticotropin to initiate a change in cell activity. |
MC2R |
GO:0004980 | MF | melanocyte-stimulating hormone receptor activity | Combining with melanocyte-stimulating hormone to initiate a change in cell activity. |
MC4R |
GO:0004982 | MF | N-formyl peptide receptor activity | Combining with an N-formyl peptide to initiate a change in cell activity. |
GPR32, FPR1, FPR2 |
GO:0004983 | MF | neuropeptide Y receptor activity | Combining with neuropeptide Y to initiate a change in cell activity. |
NPY1R, NPY2R, NPY5R |
GO:0004984 | MF | olfactory receptor activity | Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. |
OR3A3, OR52E8, OR5A2, OR5L2, OR14C36, OR2A5, OR51E2 |
GO:0004985 | MF | opioid receptor activity | Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein. |
NPBWR1, SIGMAR1 |
GO:0004990 | MF | oxytocin receptor activity | Combining with oxytocin to initiate a change in cell activity. |
OXTR |
GO:0004991 | MF | parathyroid hormone receptor activity | Combining with parathyroid hormone to initiate a change in cell activity. |
PTH2R |
GO:0004992 | MF | platelet activating factor receptor activity | Combining with platelet activating factor to initiate a change in cell activity. |
PDGFRB, PTAFR |
GO:0004993 | MF | G-protein coupled serotonin receptor activity | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. |
HTR2C, HTR7, HTR2B |
GO:0004994 | MF | somatostatin receptor activity | Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G-protein coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). |
SSTR1, SSTR5 |
GO:0004996 | MF | thyroid-stimulating hormone receptor activity | Combining with thyroid-stimulating hormone to initiate a change in cell activity. |
PAX8 |
GO:0004998 | MF | transferrin receptor activity | Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates. |
TFRC, TFR2 |
GO:0004999 | MF | vasoactive intestinal polypeptide receptor activity | Combining with vasoactive intestinal polypeptide to initiate a change in cell activity. |
ADCYAP1R1 |
GO:0005000 | MF | vasopressin receptor activity | Combining with vasopressin to initiate a change in cell activity. |
AVPR2, OXTR, INPP5K |
GO:0005001 | MF | transmembrane receptor protein tyrosine phosphatase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
PTPRC, PTPRF, PTPRB, PTPRD, PTPRG, PTPRM, PTPRK, PTPRO |
GO:0005003 | MF | ephrin receptor activity | Combining with an ephrin to initiate a change in cell activity. |
EPHA5, EPHB4, EPHA6 |
GO:0005004 | MF | GPI-linked ephrin receptor activity | Combining with a GPI-anchored ephrin to initiate a change in cell activity. |
NTRK1, EPHA3, EPHA5, EPHA4 |
GO:0005005 | MF | transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
EPHB2, EFNA4, EPHA5, EPHB1, EPHA4 |
GO:0005006 | MF | epidermal growth factor-activated receptor activity | Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
EGFR, EFEMP1 |
GO:0005007 | MF | fibroblast growth factor-activated receptor activity | Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
FGFR1, FGFR2 |
GO:0005008 | MF | hepatocyte growth factor-activated receptor activity | Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
MET |
GO:0005009 | MF | insulin-activated receptor activity | Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
INSR |
GO:0005010 | MF | insulin-like growth factor-activated receptor activity | Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
IGF1R, IGF2R, CRIM1 |
GO:0005011 | MF | macrophage colony-stimulating factor receptor activity | Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
CSF1R |
GO:0005017 | MF | platelet-derived growth factor-activated receptor activity | Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
PDGFRB |