| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0004666 | MF | prostaglandin-endoperoxide synthase activity | Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. |
PTGS1, PTGS2 |
GO:0004667 | MF | prostaglandin-D synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). |
PTGDS |
GO:0004668 | MF | protein-arginine deiminase activity | Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3. |
PADI4 |
GO:0004671 | MF | protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. |
ICMT |
GO:0004672 | MF | protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
CDC7, CHEK1, AURKA, DCLK1, MAP3K7, BUB1, BUB1B, JAK2, RPS6KA5, STK17B, RAF1, CDK1, CCL3, CCL2, CCL5, PDGFRA, PRKCA, ERCC2, NPR2, MAK, CDK11B, CAD, LTK, AKT1, GTF2H1, ADRBK2, TGFBR1, PRKCI, ABL2, SYK, SOX9, CSNK1A1, CSNK1D, PIK3CG, MAPKAPK2, CDK8, CSNK1E, GSK3B, CDK7, IRAK1, NEK2, PLK1, DAPK1, PRKAG1, PRKAA2, EPHA4, PRKDC, CCL8, CDK5, MAP2K1, TEK, GUCY2D, PRKCQ, ACVR1, PTK2, PRKCD, RNASEL, STK4, MAP2K5, PAK2, TRIM28, PTK7, PRPF4B, RIPK1, GTF2H2, CDK13, PDK1, MMD, PKN1, PKN2, PDK4, PAN3, NEK10, SGK223, MAP4K3, TEX14, MINK1, PIK3C3, GSG2, GTF2H4, TBRG4, SGK3, NEK1, SMG1, SRPK1, PIK3R4, PKMYT1, MAP3K5, VRK1, PINK1, WNK3, PRKD2, HIPK2, WNK1, CDK12, NLK, TBK1, TNIK, CDK11A, AKT3, MAP4K5, CDC42BPB, STK24, CSNK1G3 |
GO:0004673 | MF | protein histidine kinase activity | Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. |
NME2 |
GO:0004674 | MF | protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
CDC7, PLK4, RIOK3, CHEK1, CASK, AURKA, MAST4, DCLK1, MAPK13, IRAK2, MAP3K13, DAPK3, MAP3K7, RIPK2, BUB1, NUAK1, CCNT1, BUB1B, CCNT2, ROCK2, ULK1, ERN1, RPS6KA5, PAK3, STK17B, MAP4K4, LATS1, RAF1, PRKCB, CDK1, BCR, PSKH1, PRKCA, PRKACA, CDK11B, NME2, CDK2, ACVR2A, MAPK3, MAPK1, AKT1, AKT2, TTK, GRK5, MAP2K2, BMPR1A, ACVR1B, TGFBR1, MAP3K8, PRKCI, PIK3CA, SYK, MAPK8, CSNK1A1, CSNK1D, PIK3CG, MAPKAPK2, CDK8, CSNK1E, CLK2, GSK3B, CDK7, IRAK1, NEK2, NEK3, NEK4, PLK1, DAPK1, LIMK2, PRKAA2, SIK1, SRPK2, PRKDC, CDK5, CDK16, MAP2K1, PRKCQ, ACVR1, PRKCD, TNK2, DMPK, STK4, MAPK7, PAK2, ILK, SQSTM1, PRPF4B, RIPK1, CAMK2D, ACVR2B, FASTK, MELK, PRKD1, STK38, RPS6KA2, RPS6KA1, TESK1, STK11, PKN1, PKN2, MAPK14, AAK1, SBK1, CDC42BPA, MAST2, DSTYK, AATK, NEK10, NEK8, STK32C, MAP4K3, FAM20C, MINK1, STKLD1, ANKK1, NEK11, UHMK1, OSR1, NEK9, STK35, NEK7, TTN, DYRK2, SGK3, ULK4, AURKB, MASTL, PBK, MARK4, SMG1, ALPK1, TRPM7, PASK, TP53RK, SRPK1, PIK3R4, PKMYT1, MAP3K5, VRK1, MKNK1, TRPM6, PINK1, WNK3, PRKD2, SIK2, TAOK3, HIPK2, WNK1, CLK4, MKNK2, NEK6, CSNK1G1, LATS2, SNX15, NRBP2, BMP2K, ZAK, PLK2, MARK1, EIF2AK4, NLK, TBK1, TNIK, TLK1, TAOK2, CDK11A, AKT3, STK38L, SIK3, CAB39, MAP4K5, CDC42BPB, IRAK3, STK24, CSNK1G3 |
GO:0004675 | MF | transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
ACVR2A, BMPR1A, ACVR1B, TGFBR2, ACVR1 |
GO:0004677 | MF | DNA-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA. |
HMGA2, PRKDC, XRCC6BP1 |
GO:0004679 | MF | AMP-activated protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. |
PRKAG1, PRKAA2, PRKAG3 |
GO:0004683 | MF | calmodulin-dependent protein kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin. |
ITPKA, MAPKAPK2, DAPK1, CAMK2D, CAMK1, PNCK, CAMK1D, MKNK1, MKNK2 |
GO:0004687 | MF | myosin light chain kinase activity | Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. |
MYLK |
GO:0004689 | MF | phosphorylase kinase activity | Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. |
PHKA2, PHKA1 |
GO:0004691 | MF | cAMP-dependent protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP. |
PRKACA, PRKX, PRKAG1, AKAP13 |
GO:0004693 | MF | cyclin-dependent protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). |
CCNB2, CDK1, CDK4, CCNB1, MAK, CDK11B, CDK2, CCND3, CDK8, CDK7, CDK3, CDK6, CDK5, CDK16, CDK13, CDK10, CDK19, CDK12, CDK11A |
GO:0004694 | MF | eukaryotic translation initiation factor 2alpha kinase activity | Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. |
EIF2AK4 |
GO:0004697 | MF | protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. |
PRKCB, PRKCA, PRKCI, PRKCQ, PRKCD, PRKD1, PKN1, PKN2, PRKD2 |
GO:0004698 | MF | calcium-dependent protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium. |
PRKCB, CCL3, PRKCA |
GO:0004699 | MF | calcium-independent protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium. |
PRKCD |
GO:0004702 | MF | receptor signaling protein serine/threonine kinase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
MAP2K7, PAK3, MAP4K4, ACVR2A, MAP2K2, BMPR1A, ACVR1B, TGFBR1, TGFBR2, MAP3K8, NEK4, MAP2K6, TGFB2, MAP2K1, ACVR1, STK4, MAP2K5, PAK2, ACVR2B, BMPR2, AMHR2, NRK, MAP4K3, MINK1, NEK1, TAOK3, PAK7, TNIK, TAOK2, MAP4K5, STK24 |
GO:0004703 | MF | G-protein coupled receptor kinase activity | Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate. |
GRK5, ADRBK2, GRK6 |
GO:0004704 | MF | NF-kappaB-inducing kinase activity | Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK). |
IRAK1, PPP4C |
GO:0004705 | MF | JUN kinase activity | Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. |
MAPK8, MAPK9 |
GO:0004707 | MF | MAP kinase activity | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
MAPK13, MAPK3, MAPK1, MAPK7, MAPK14, NLK |
GO:0004708 | MF | MAP kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
MAP2K7, PAK3, MAP2K2, MAP2K6, MAP2K1, MAPK14 |
GO:0004709 | MF | MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
MAP3K13, MAP3K7, EGFR, RAF1, MAP3K8, MAP3K7CL, MLK4, MAP3K5, ZAK, MAP3K4 |
GO:0004711 | MF | ribosomal protein S6 kinase activity | Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. |
RPS6KA2 |
GO:0004712 | MF | protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
AURKA, PRKACA, AKT1, TTK, MAP2K2, CLK2, PRKAA2, MAP2K1, TNK2, ACVR2B, RPS6KA2, RPS6KA1, TESK1, DSTYK, DYRK2, AURKB, CLK4 |
GO:0004713 | MF | protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
MAP2K7, EREG, MUSK, JAK2, FGF18, ERLIN2, EGFR, ERBB2, INSR, FYN, HSP90AA1, LYN, IGF1R, MET, FGF2, PDGFRB, FGR, KIT, BCR, FGFR1, FGF7, FGFR2, ERBB3, JAK1, EPHB2, LTK, WEE1, FGF9, TTK, BTC, MAP2K2, CSK, STAT5A, ABL2, SYK, CLK2, STAT5B, JAK3, MAP2K6, IL5RA, NRG1, MAP2K1, TEK, PTK2, TYRO3, TNK2, MAP2K5, CUX1, ERBB4, TESK1, CDC37, DSTYK, TTN, DYRK2, SCYL1, NEK1, HBEGF, CLK4, FGFR1OP2, ZMYM2, BAZ1B |
GO:0004714 | MF | transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
MUSK, EGFR, ERBB2, NTRK1, KIT, PDGFRA, LTK, TIE1, FLT4, EPHB4, ROR1, TEK, TYRO3, DDR1, MERTK, ERBB4 |
GO:0004715 | MF | non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. |
RIPK2, JAK2, FYN, LYN, FGR, JAK1, WEE1, CSK, ABL2, SYK, JAK3, PTK2, PRKCD, TNK2, MELK, STYK1, SGK223, BAZ1B |
GO:0004716 | MF | receptor signaling protein tyrosine kinase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
EGFR, ERBB2, INSR, LYN, KIT, SYK, TYRO3, ERBB4 |
GO:0004719 | MF | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. |
PCMT1, PCMTD1 |
GO:0004720 | MF | protein-lysine 6-oxidase activity | Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide. |
LOX, LOXL2 |
GO:0004721 | MF | phosphoprotein phosphatase activity | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
PLPP3, CTDSPL, CDC25A, CDC25B, CDC25C, PPP1CC, PTEN, PPP1CA, PTPN11, DLG1, MTM1, DLGAP5, TIMM50, TNS2, SSH2, PPP1R3B, DUSP9, CPPED1, DUSP26, DUSP16, PHPT1, PPM1H, CDC14A, DUSP10 |
GO:0004722 | MF | protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
PP2D1, PPP6C, PPM1G, CDC14B, PPM1B, CTDNEP1, PPP1R3D, PPP2R1A, PPP1CC, PPM1F, PTEN, PPP4C, PPP1CA, PPP2CB, CYCS, PPP3CA, PPP2R5D, TAB1, CDKN3, TIMM50, PPM1J, PHLPP2, PPM1K, PPTC7, UBLCP1, PPM1E, DUSP23, PPA2, MTMR4, PDP1, PPM1H, CDC14A |
GO:0004725 | MF | protein tyrosine phosphatase activity | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
PTPDC1, EYA2, CDC14B, DUSP11, EYA4, PTPRC, PTPRF, PTPN2, PTPRG, PTPRM, CDC25A, CDC25B, CDC25C, PTPN9, DUSP3, TPTE, PTEN, DUSP2, PTPN11, PTPRJ, DUSP8, MTM1, MTMR1, MTMR2, PTPRK, CDKN3, DUSP5, PTPN21, PTPRO, DUSP6, DUSP7, TIMM50, SSH2, DUSP18, SSH3, UBASH3B, DUSP19, PTPMT1, PTP4A1, DUSP9, DUSP26, DUSP23, DUSP16, DUSP21, DUSP22, MTMR4, DUSP13, CDC14A, PTPN22, DUSP10 |
GO:0004726 | MF | non-membrane spanning protein tyrosine phosphatase activity | Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. |
PTPN2, DUSP1, PTPN4, PTPN9, PTPN11 |
GO:0004727 | MF | prenylated protein tyrosine phosphatase activity | Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. |
PTP4A2 |
GO:0004728 | MF | receptor signaling protein tyrosine phosphatase activity | Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
MAP2K1 |
GO:0004731 | MF | purine-nucleoside phosphorylase activity | Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. |
PNP |
GO:0004735 | MF | pyrroline-5-carboxylate reductase activity | Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. |
PYCRL |
GO:0004736 | MF | pyruvate carboxylase activity | Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate. |
PC |
GO:0004738 | MF | pyruvate dehydrogenase activity | Catalysis of the oxidative decarboxylation of pyruvate. |
PDHA1, PDHB |
GO:0004739 | MF | pyruvate dehydrogenase (acetyl-transferring) activity | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. |
PDHA1, PDHB |
GO:0004740 | MF | pyruvate dehydrogenase (acetyl-transferring) kinase activity | Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. |
PDK1, PDK4 |
GO:0004741 | MF | [pyruvate dehydrogenase (lipoamide)] phosphatase activity | Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate. |
PDP1 |
GO:0004742 | MF | dihydrolipoyllysine-residue acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. |
DLAT |
GO:0004743 | MF | pyruvate kinase activity | Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. |
PKM |
GO:0004745 | MF | retinol dehydrogenase activity | Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. |
HSD17B6, DHRS3, BMP2, ADH7, AKR1C3, RDH10, RDH11, DHRS9 |
GO:0004748 | MF | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. |
RRM1, RRM2 |
GO:0004749 | MF | ribose phosphate diphosphokinase activity | Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). |
PRPS2, PRPS1 |
GO:0004756 | MF | selenide, water dikinase activity | Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate. |
SEPHS1 |
GO:0004758 | MF | serine C-palmitoyltransferase activity | Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA. |
SPTLC2, SPTSSB |
GO:0004760 | MF | serine-pyruvate transaminase activity | Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. |
AGXT |
GO:0004766 | MF | spermidine synthase activity | Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. |
SRM |
GO:0004767 | MF | sphingomyelin phosphodiesterase activity | Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). |
SMPD4 |
GO:0004768 | MF | stearoyl-CoA 9-desaturase activity | Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O. |
SCD, FADS2, SCD5 |
GO:0004769 | MF | steroid delta-isomerase activity | Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. |
HSD3B1, HSD3B2, EBP |
GO:0004771 | MF | sterol esterase activity | Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. |
LIPA |
GO:0004772 | MF | sterol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester. |
SOAT1 |
GO:0004773 | MF | steryl-sulfatase activity | Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. |
STS |
GO:0004775 | MF | succinate-CoA ligase (ADP-forming) activity | Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. |
SUCLG1, SUCLA2 |
GO:0004776 | MF | succinate-CoA ligase (GDP-forming) activity | Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. |
SUCLG1 |
GO:0004778 | MF | succinyl-CoA hydrolase activity | Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate. |
ACOT4 |
GO:0004781 | MF | sulfate adenylyltransferase (ATP) activity | Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. |
PAPSS2 |
GO:0004782 | MF | sulfinoalanine decarboxylase activity | Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. |
CSAD |
GO:0004784 | MF | superoxide dismutase activity | Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. |
CCS, SOD2, SOD3, NQO1 |
GO:0004788 | MF | thiamine diphosphokinase activity | Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. |
TPK1 |
GO:0004791 | MF | thioredoxin-disulfide reductase activity | Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide. |
TXNRD1 |
GO:0004792 | MF | thiosulfate sulfurtransferase activity | Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate. |
MPST |
GO:0004797 | MF | thymidine kinase activity | Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. |
TK2, TK1 |
GO:0004798 | MF | thymidylate kinase activity | Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. |
DTYMK, CMPK2 |
GO:0004799 | MF | thymidylate synthase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. |
TYMS |
GO:0004800 | MF | thyroxine 5'-deiodinase activity | Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. |
DIO2 |
GO:0004801 | MF | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity | Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. |
TALDO1 |
GO:0004802 | MF | transketolase activity | Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. |
TKT |
GO:0004803 | MF | transposase activity | Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. |
ZBED1 |
GO:0004806 | MF | triglyceride lipase activity | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. |
LPL, AADAC, LIPE, PNPLA5, PNPLA2, PNPLA3 |
GO:0004807 | MF | triose-phosphate isomerase activity | Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. |
TPI1 |
GO:0004810 | MF | tRNA adenylyltransferase activity | Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1). |
TRNT1 |
GO:0004814 | MF | arginine-tRNA ligase activity | Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). |
RARS |
GO:0004815 | MF | aspartate-tRNA ligase activity | Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). |
DARS |
GO:0004818 | MF | glutamate-tRNA ligase activity | Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). |
EPRS, EARS2 |
GO:0004821 | MF | histidine-tRNA ligase activity | Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). |
HARS, HARS2 |
GO:0004823 | MF | leucine-tRNA ligase activity | Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu). |
LARS2 |
GO:0004824 | MF | lysine-tRNA ligase activity | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
KARS |
GO:0004826 | MF | phenylalanine-tRNA ligase activity | Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
FARS2, FARSA |
GO:0004827 | MF | proline-tRNA ligase activity | Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). |
EPRS, PARS2 |
GO:0004828 | MF | serine-tRNA ligase activity | Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). |
SARS |
GO:0004829 | MF | threonine-tRNA ligase activity | Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). |
TARS |
GO:0004831 | MF | tyrosine-tRNA ligase activity | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). |
YARS |
GO:0004832 | MF | valine-tRNA ligase activity | Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). |
YARS |
GO:0004835 | MF | tubulin-tyrosine ligase activity | Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. |
TTL |
GO:0004839 | MF | ubiquitin activating enzyme activity | Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. |
UBA6, UBA1, UBA7, SAE1 |
GO:0004842 | MF | ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
ASB14, RNF103, WWP2, PEX12, UBE2C, BACH1, BIRC5, SIAH2, PARK2, TRIM13, FBXO24, RNF8, TRIM37, UBR5, CNOT4, RAG1, TNFAIP3, UBA1, TRIM23, BRCA1, UBA7, CDC34, UBE2A, UBE2E1, TTC3, UBE2D3, UBE2M, UBE2H, RBX1, UBE2B, SKP1, XIAP, MDM2, CBLB, TRIM28, SKP2, BIRC3, CUL3, TRIM25, SHPRH, HERC3, TCEB1, UBE3C, UBE2S, LONRF1, KLHL12, HERC4, MARCH8, UBR4, HECTD2, FBXO31, RFWD3, KLHL24, CYHR1, PDZRN4, RNF19B, UBR3, CBLL1, MAEA, RNF144B, RBBP6, HUWE1, TRIM69, RNF130, MIB1, SIAH1, KLHL7, KBTBD2, KLHDC8A, HACE1, KLHL36, RNF182, RNF152, KLHL23, FBXO22, FBXO25, MARCH1, RNF141, MYLIP, KCTD13, CUL5, FBXO32, UBE2E3, MIB2, UBE2W, KLHDC7B, RMND5B, ITCH, ZFP91, UBE2E2, KLHL15, KLHL32, ASB16, KLHL5, UHRF2, NEDD4L, UHRF1, MPHOSPH8, BARD1, FEM1A, TRIM62, BACH2, TRIM9, TRIM2, KLHL4, RNF38, WWP1, KCTD10, FBXL15, RMND5A, SMURF2, RC3H2, UBE2T, RNF146, RNF19A, RLIM, RNF216, KLHL28, DTL, RNF181, KLHL8, KLHL9, KLHL42, KLHL13, HECW2, KLHL3, MKRN1, FBXL7, CDC23, ANAPC4, FEM1B, FBXO10, FBXO9, FBXL2, AMFR, STUB1, TRIM33, PDZRN3, RNF6, BTRC, UBE2D4, ARIH1, RNF114, ASB3 |
GO:0004843 | MF | thiol-dependent ubiquitin-specific protease activity | Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. |
USP27X, USP12, USP2, USP1, STAMBP, UCHL1, UCHL3, TNFAIP3, USP6, BRCC3, USP11, ATXN3, USP46, JOSD1, OTUD1, OTUD7B, USP34, USP31, USP51, USP45, USP48, USP32, BAP1, TANK, UFD1L, USP13, OTUB2, OTUB1, VCPIP1, USP28, USP44, USP42, CYLD, USP36, USP35, ZRANB1, USP25, USP22, USP20, USP15, UCHL5 |
GO:0004844 | MF | uracil DNA N-glycosylase activity | Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. |
UNG, TDG, SMUG1 |
GO:0004849 | MF | uridine kinase activity | Catalysis of the reaction: ATP + uridine = ADP + UMP. |
CMPK1, UPRT, UCK2, UCK1, UCKL1 |
GO:0004850 | MF | uridine phosphorylase activity | Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. |
UPP2, UPP1 |