GO:0004499

MF

N,N-dimethylaniline monooxygenase activity

Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

FMO4, FMO2

GO:0004502

MF

kynurenine 3-monooxygenase activity

Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+).

KMO

GO:0004503

MF

monophenol monooxygenase activity

Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.

TYR

GO:0004504

MF

peptidylglycine monooxygenase activity

Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.

PAM

GO:0004506

MF

squalene monooxygenase activity

Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).

SQLE

GO:0004507

MF

steroid 11-beta-monooxygenase activity

Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.

CYP11B1, CYP11B2

GO:0004508

MF

steroid 17-alpha-monooxygenase activity

Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.

CYP17A1

GO:0004509

MF

steroid 21-monooxygenase activity

Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.

CYP21A2

GO:0004510

MF

tryptophan 5-monooxygenase activity

Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.

TPH2

GO:0004511

MF

tyrosine 3-monooxygenase activity

Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.

TH

GO:0004512

MF

inositol-3-phosphate synthase activity

Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.

ISYNA1

GO:0004514

MF

nicotinate-nucleotide diphosphorylase (carboxylating) activity

Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate.

NAMPT, QPRT

GO:0004515

MF

nicotinate-nucleotide adenylyltransferase activity

Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+.

NMNAT3

GO:0004517

MF

nitric-oxide synthase activity

Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.

NOS3

GO:0004518

MF

nuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids.

PARN, TDP2, MRE11A, DNA2, TATDN3, PGAP1, FANCM

GO:0004519

MF

endonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

ZC3H12D, ANG, RNASE2, RAG1, RNASE4, FEN1, NTHL1, G3BP1, TSN, ZC3H12B, DCLRE1C, ELAC2, PELO, ZC3H12C, EXOG, DIS3

GO:0004520

MF

endodeoxyribonuclease activity

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.

RAD51D, MBD4, MRE11A, RAD51, ERCC4, EME1

GO:0004521

MF

endoribonuclease activity

Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

ERN1, RNASEL, LACTB2, RNASEK, ZC3H3, AGO2, NOB1, DICER1, RCL1

GO:0004522

MF

ribonuclease A activity

Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.

RNASE1, RNASE2, RNASE4

GO:0004523

MF

RNA-DNA hybrid ribonuclease activity

Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

RNASEH2A, FEN1, RNASEH2B, EXO1

GO:0004525

MF

ribonuclease III activity

Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.

MRPL44, DICER1

GO:0004526

MF

ribonuclease P activity

Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.

KIAA0391, POP7, RPP40, POP4, RPP30, POP5, RPP25

GO:0004527

MF

exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.

ERI2, ERI3, FEN1, XRN1, REXO1, ISG20, TDP1, EXO1

GO:0004528

MF

phosphodiesterase I activity

Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.

ENPP3, ENPP1, ENPP2, FAN1

GO:0004530

MF

deoxyribonuclease I activity

Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.

DICER1

GO:0004532

MF

exoribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.

CNOT7, CNOT6

GO:0004535

MF

poly(A)-specific ribonuclease activity

Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.

CNOT1, PARN, PAN3, CNOT7, NOCT, CNOT6

GO:0004536

MF

deoxyribonuclease activity

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.

NME1, TATDN1

GO:0004540

MF

ribonuclease activity

Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.

RNASET2, RNASEH2A, ANG, RNASE2, AZGP1, RNASE4, SMG5

GO:0004549

MF

tRNA-specific ribonuclease activity

Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.

ELAC2

GO:0004550

MF

nucleoside diphosphate kinase activity

Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

NME4, NME6, AK1, NME1, NME2, AK4, CMPK1, PCK1, CMPK2, AK8, NME7

GO:0004551

MF

nucleotide diphosphatase activity

Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.

ENPP3, ENPP1, ENPP2

GO:0004553

MF

hydrolase activity, hydrolyzing O-glycosyl compounds

Catalysis of the hydrolysis of any O-glycosyl bond.

GBE1, CHIT1, ABHD10, GNE

GO:0004556

MF

alpha-amylase activity

Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.

AMY2B

GO:0004558

MF

alpha-1,4-glucosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

MGAM, GAA

GO:0004559

MF

alpha-mannosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

MAN2B1, MAN2A2, EDEM1, EDEM3, MAN1B1, MAN2B2

GO:0004560

MF

alpha-L-fucosidase activity

Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose.

FUCA1, FUCA2

GO:0004561

MF

alpha-N-acetylglucosaminidase activity

Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.

NAGLU

GO:0004563

MF

beta-N-acetylhexosaminidase activity

Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

HEXA

GO:0004565

MF

beta-galactosidase activity

Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.

GLB1L2

GO:0004566

MF

beta-glucuronidase activity

Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.

KL, HPSE

GO:0004568

MF

chitinase activity

Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins.

CTBS, CHIT1

GO:0004569

MF

glycoprotein endo-alpha-1,2-mannosidase activity

Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane.

MANEA, EDEM3

GO:0004571

MF

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.

MAN1A1, EDEM1, EDEM3, MAN1C1, MAN1B1

GO:0004572

MF

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).

MAN2A2

GO:0004574

MF

oligo-1,6-glucosidase activity

Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose.

GAA

GO:0004576

MF

oligosaccharyl transferase activity

Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid.

DDOST, DAD1

GO:0004577

MF

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol.

ALG13

GO:0004579

MF

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.

DDOST, STT3A, DAD1, STT3B, OSTC

GO:0004582

MF

dolichyl-phosphate beta-D-mannosyltransferase activity

Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.

DPM3

GO:0004583

MF

dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity

Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide.

ALG10B, ALG8, ALG6

GO:0004586

MF

ornithine decarboxylase activity

Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine.

ODC1

GO:0004588

MF

orotate phosphoribosyltransferase activity

Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.

UMPS

GO:0004590

MF

orotidine-5'-phosphate decarboxylase activity

Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP.

UMPS

GO:0004591

MF

oxoglutarate dehydrogenase (succinyl-transferring) activity

Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.

MRPS36, OGDH

GO:0004594

MF

pantothenate kinase activity

Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.

PANK2, PANK3

GO:0004595

MF

pantetheine-phosphate adenylyltransferase activity

Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.

COASY

GO:0004596

MF

peptide alpha-N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.

NAA30, NAA25, NAA15, NAA50, NAA60

GO:0004597

MF

peptide-aspartate beta-dioxygenase activity

Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2.

ASPH

GO:0004598

MF

peptidylamidoglycolate lyase activity

Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate.

PAM

GO:0004601

MF

peroxidase activity

Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.

MGST3, MPO, PTGS1, PTGS2, HBB, HBA1, PRDX1, GPX8, CYGB, IPCEF1, GPX7, DUOX2, DUOX1

GO:0004602

MF

glutathione peroxidase activity

Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.

MGST3, GSTZ1, GPX1, GSTA1, GSTP1, MGST1, GPX3, GSTM2, PRDX6, GSTT1, GPX4, GPX8, GPX7, MGST2, GSTK1

GO:0004603

MF

phenylethanolamine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.

PNMT

GO:0004605

MF

phosphatidate cytidylyltransferase activity

Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

CDS2, CDS1

GO:0004608

MF

phosphatidylethanolamine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine.

PEMT

GO:0004611

MF

phosphoenolpyruvate carboxykinase activity

Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products.

PCK2

GO:0004613

MF

phosphoenolpyruvate carboxykinase (GTP) activity

Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.

PCK1, PCK2

GO:0004614

MF

phosphoglucomutase activity

Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

PGM1, PGM2

GO:0004615

MF

phosphomannomutase activity

Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

PMM2

GO:0004616

MF

phosphogluconate dehydrogenase (decarboxylating) activity

Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.

HIBADH, PGD, GLYR1

GO:0004617

MF

phosphoglycerate dehydrogenase activity

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.

PHGDH

GO:0004618

MF

phosphoglycerate kinase activity

Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+).

PGK1

GO:0004619

MF

phosphoglycerate mutase activity

Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.

PGAM1

GO:0004620

MF

phospholipase activity

Catalysis of the hydrolysis of a glycerophospholipid.

LPL, LIPH, ABHD6, LIPG

GO:0004621

MF

glycosylphosphatidylinositol phospholipase D activity

Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.

GPLD1

GO:0004622

MF

lysophospholipase activity

Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

LYPLA1, PLA2G4A, ENPP2, ABHD12, MGLL, PNPLA8, LGALS13, PLA2G4C

GO:0004623

MF

phospholipase A2 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, PAFAH1B2, PAFAH1B3, PLA2G12A, PNPLA8, PNPLA3, PLA2G4C

GO:0004629

MF

phospholipase C activity

Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.

PLCG2, PDIA3, ADORA1, PLCL1

GO:0004630

MF

phospholipase D activity

Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.

HMOX1, GPLD1, PLD1

GO:0004634

MF

phosphopyruvate hydratase activity

Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.

ENO1, ENO2, ENO3

GO:0004637

MF

phosphoribosylamine-glycine ligase activity

Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.

GART

GO:0004638

MF

phosphoribosylaminoimidazole carboxylase activity

Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).

PAICS

GO:0004639

MF

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.

PAICS

GO:0004641

MF

phosphoribosylformylglycinamidine cyclo-ligase activity

Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.

GART

GO:0004642

MF

phosphoribosylformylglycinamidine synthase activity

Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

PFAS

GO:0004644

MF

phosphoribosylglycinamide formyltransferase activity

Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.

GART

GO:0004645

MF

phosphorylase activity

Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase.

TYMP, MTAP

GO:0004647

MF

phosphoserine phosphatase activity

Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate.

DUSP26

GO:0004648

MF

O-phospho-L-serine:2-oxoglutarate aminotransferase activity

Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.

PSAT1

GO:0004651

MF

polynucleotide 5'-phosphatase activity

Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate.

DUSP11

GO:0004652

MF

polynucleotide adenylyltransferase activity

Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.

PAPOLA, PAPD4, PAPD5, PAPOLG, MTPAP

GO:0004653

MF

polypeptide N-acetylgalactosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.

GALNT2, GALNT1, GALNT5, GALNT7, GALNT10, GALNT15, GALNT4, GALNT14

GO:0004654

MF

polyribonucleotide nucleotidyltransferase activity

Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.

PNPT1

GO:0004655

MF

porphobilinogen synthase activity

Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen.

ALAD

GO:0004656

MF

procollagen-proline 4-dioxygenase activity

Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.

P4HA2, P4HB, P4HA1

GO:0004657

MF

proline dehydrogenase activity

Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.

PRODH

GO:0004658

MF

propionyl-CoA carboxylase activity

Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

PCCA

GO:0004661

MF

protein geranylgeranyltransferase activity

Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.

PGGT1B

GO:0004662

MF

CAAX-protein geranylgeranyltransferase activity

Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.

PGGT1B

GO:0004663

MF

Rab geranylgeranyltransferase activity

Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.

CHM, RABGGTB