| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0003730 | MF | mRNA 3'-UTR binding | Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. |
IGF2BP3, HNRNPR, PARN, HNRNPC, HNRNPA2B1, ZFP36, ZFP36L2, FXR1, PCBP4, FMR1, ZFP36L1, CRYZ, TARDBP, AUH, CIRBP, PUM1, RNPS1, ELAVL1, CPEB4, LARP1, CPEB2, SERBP1, CPEB3, PUM2, SECISBP2L, SECISBP2, RBM4, RBM24, CARHSP1, IGF2BP2 |
GO:0003735 | MF | structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
MRPS12, SLC25A17, MRPS14, MRPL33, SLC25A12, NDUFA7, SLC25A14, SLC25A5, RPLP1, RPLP2, RPLP0, RPS17, RPSA, SLC25A4, RPS2, SLC25A16, RPL35A, RPL7, RPL17, RPS4Y1, UCP1, RPL13, RPL10, RPL12, RPL22, RPL4, RPL13A, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, RPL29, RPL34, MRPL19, RPL14, DAP3, MRPL12, SLC25A1, UCP2, UCP3, RPS20, RPS3A, RPL26, RPL15, RPL27, RPL37A, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, UBA52, RPL38, RPS21, MRPS25, MRPS5, MRPS36, MRPS21, MRPS34, RPL24, RPL36A, RPL19, SLC25A3, RPL18A, RPL18, MRPL23, MRPL51, SLC25A30, MRPL14, RPL22L1, SLC25A26, RPS27L, MRPL21, MRPL55, MRPL52, MRPL41, MRPL30, SLC25A43, MRPS31, RPL36AL, SLC25A36, RPL39L, SLC25A44, MRPL34, MRPL57, SLC25A23, MRPL32, MRPL4, MRPL1, MRPL37, SLC25A39, SLC25A18, SLC25A19, MRPL47, MRPL17, MRPS18A, MRPL16, SLC25A37, MRPL35, MRPL15, MRPL36, SLC25A10, SLC25A13, MRPS2, RPL36, SLC25A15, MRPS18B, MRPL42 |
GO:0003743 | MF | translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
EIF4G3, DENR, EIF4E2, EIF1B, EIF5B, EIF3J, EIF2S1, EIF4E, EIF4B, EIF2S3, EIF1, EIF1AX, EIF5, EIF3B, EIF6, EIF4A1, EIF2B5, EIF3A, EIF2B1, EIF4A2, DHX29, EIF1AD, MTIF3, EIF2B3, EIF3K, EIF2B4, AGO2 |
GO:0003746 | MF | translation elongation factor activity | Functions in chain elongation during polypeptide synthesis at the ribosome. |
EEF1E1, EEF2, EEF1B2, EEF1D, TSFM, EIF5A, EEF1A1, EEF1A2, GFM1, EIF5A2, HBS1L |
GO:0003747 | MF | translation release factor activity | Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. |
GSPT1 |
GO:0003755 | MF | peptidyl-prolyl cis-trans isomerase activity | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
PPIH, PPIB, FKBP2, PPIF, NKTR, PPIC, RANBP2, PPIA, FKBP3, FKBP4, PPID, PPIL2, PPIG, FKBP5, PPP2R4, CWC27, PPIL4, FKBP10, FKBP14, FKBP11, PPIE, PIN4, FKBP7 |
GO:0003756 | MF | protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
ITGB3, P4HB, PDIA4, PDIA3, PDIA5, PDIA6, TXNDC11, QSOX2, ERO1B, PIGK, ERO1A, ERP44, TMX4, GLRX2 |
GO:0003774 | MF | motor activity | Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. |
MYO1G, DYNC1I1, KIF1C, MYL6B, MYH9, MYH11, MYL6, DYNLL1, DYNLT1, MYO1E, DCTN2, DCTN1, KIF18B, DYNC2LI1, MYO10, KIF15, DNAH9, DNAI1, MYO6 |
GO:0003777 | MF | microtubule motor activity | Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). |
DYNC1I1, DNALI1, DYNC1LI2, KIF1C, KIF5C, KIF1B, KIF20A, KIF4A, DNAL4, KIF11, CENPE, KIF23, DNAH14, DYNC1I2, DYNC1H1, KIF22, KIF14, KLC3, DNAH12, DNAH10, DNAH5, APPBP2, DNAH11, KIF2C, KIFC1, KIF13B, KIF15, DNAH9, DNAH1, STARD9, SMC3 |
GO:0003779 | MF | actin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
WASH1, MYO1G, MYO1C, HIP1, WASL, ABLIM1, ENC1, ACTN4, PARK2, DIAPH2, PHACTR2, FLNB, RP2, MICAL2, ABLIM3, GC, ANG, ALDOA, ITGB1, TPM3, PFN1, TPM2, TPM1, DMD, LCP1, HCLS1, EZR, SYN1, TNNI3, S100A4, TMOD1, LMOD1, CORO1A, GBP1, LSP1, NF2, RDX, MYH9, CAPG, CAPZB, EMD, CNN1, CAPZA1, SMTN, CXCR4, NCALD, TPM4, MYBPC1, SPTBN1, TAGLN, DST, YWHAH, PTK2, CALD1, KCNMA1, EPS8, SNTA1, SNTB2, MYO9B, IQGAP2, SHROOM2, SNTB1, COTL1, DAG1, CNN3, DIXDC1, MYLK, DBN1, FSCN1, CCDC88A, CROCC, MPRIP, SSH2, MAEA, PXK, GAS2L3, PLEKHH2, PHACTR4, ENAH, JMY, MYRIP, KIF18A, FBXO25, MICAL1, SSH3, PALLD, SYNE2, MIB2, MYO19, PDLIM5, PAWR, FGD4, PACRG, KLHL5, FMNL2, TRPM7, MLPH, SORBS1, KLHL4, SPTBN4, EPB41L1, PSTPIP2, TRPV4, TNS1, MYOZ1, ANLN, DIAPH3, PARVA, TBCCD1, FMN2, IMPACT, MYOT, HDAC6, ADD3, KLHL3, BAIAP2L1, EVL, MYH2, MYO5B, MYO6, SYNPO2, MACF1, LIMCH1, TRPC6, STK38L, EPB41L3, DAAM1, MYO5A, FHOD1, MYH4, WASF2 |
GO:0003785 | MF | actin monomer binding | Interacting selectively and non-covalently with monomeric actin, also known as G-actin. |
MTSS1, COBL, PFN1, TMSB15A, MYL4, NOS3, CORO1A, ABL2, TMSB4X, TMSB10, TWF1, COBLL1, TWF2, LIMA1 |
GO:0003796 | MF | lysozyme activity | Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. |
LYZL6, LYZ, LYG2 |
GO:0003810 | MF | protein-glutamine gamma-glutamyltransferase activity | Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. |
F13A1, TGM2, TGM4 |
GO:0003823 | MF | antigen binding | Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. |
IGLL5, TSPAN4, TGFB1, HLA-B, IL7R, HLA-G, LAG3, AZGP1, PPP2R1A, FCN2, MICB, MICA, HFE, MR1, SPON2, ULBP3, ULBP2 |
GO:0003824 | MF | catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
HSD17B6, AZIN1, MGAM, ALDH1L1, DDAH1, DDAH2, SLC3A2, ALAD, HSD17B1, HPGD, SYN1, CAPN3, AADAC, AOAH, GTF2F1, FHIT, ASAH1, ITPK1, PIGH, ESPL1, DIP2A, OLFM4, SPATA20, PIGC, SYN2, ECHDC3, DIP2C, MED16 |
GO:0003826 | MF | alpha-ketoacid dehydrogenase activity | Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid. |
BCKDHA, BCKDHB |
GO:0003828 | MF | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. |
ST8SIA6, ST8SIA4 |
GO:0003831 | MF | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. |
B4GALT5, B4GALT4, B4GALT1, B4GALT6 |
GO:0003835 | MF | beta-galactoside alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. |
ST6GAL1, ST6GAL2 |
GO:0003836 | MF | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R. |
ST3GAL1, ST3GAL3, ST3GAL4, ST3GAL2, ST3GAL6 |
GO:0003839 | MF | gamma-glutamylcyclotransferase activity | Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. |
CHAC2, CHAC1, GGACT |
GO:0003840 | MF | gamma-glutamyltransferase activity | Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. |
GGT7 |
GO:0003841 | MF | 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
GPAT3, LPCAT3, LCLAT1, MBOAT2, LPCAT2, GPAT4, ABHD5, LPGAT1, MBOAT7, AGPAT4, AGPAT3, CRLS1 |
GO:0003844 | MF | 1,4-alpha-glucan branching enzyme activity | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. |
GBE1 |
GO:0003845 | MF | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity | Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+). |
HSD11B1, HSD11B2 |
GO:0003846 | MF | 2-acylglycerol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. |
DGAT2 |
GO:0003847 | MF | 1-alkyl-2-acetylglycerophosphocholine esterase activity | Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. |
PAFAH1B2, PLA2G7, PAFAH1B3 |
GO:0003854 | MF | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+). |
HSD3B1, HSD3B2, NSDHL, HSD3B7 |
GO:0003857 | MF | 3-hydroxyacyl-CoA dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). |
HSD17B4, HADHB, HADH, HSD17B10, CRYL1 |
GO:0003858 | MF | 3-hydroxybutyrate dehydrogenase activity | Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH. |
BDH2 |
GO:0003860 | MF | 3-hydroxyisobutyryl-CoA hydrolase activity | Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. |
HIBCH |
GO:0003863 | MF | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity | Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. |
BCKDHA, BCKDHB |
GO:0003865 | MF | 3-oxo-5-alpha-steroid 4-dehydrogenase activity | Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. |
SRD5A1, SRD5A2 |
GO:0003867 | MF | 4-aminobutyrate transaminase activity | Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. |
ABAT |
GO:0003868 | MF | 4-hydroxyphenylpyruvate dioxygenase activity | Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. |
HPDL |
GO:0003872 | MF | 6-phosphofructokinase activity | Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. |
PFKL |
GO:0003873 | MF | 6-phosphofructo-2-kinase activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). |
PFKFB2, PFKFB1, PFKFB3, PFKFB4 |
GO:0003875 | MF | ADP-ribosylarginine hydrolase activity | Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose. |
ADPRH |
GO:0003876 | MF | AMP deaminase activity | Catalysis of the reaction: AMP + H2O = IMP + NH3. |
AMPD3 |
GO:0003880 | MF | protein C-terminal carboxyl O-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. |
ICMT, LCMT1 |
GO:0003883 | MF | CTP synthase activity | Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
CTPS1, CTPS2 |
GO:0003886 | MF | DNA (cytosine-5-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. |
DNMT1, DNMT3B |
GO:0003887 | MF | DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
REV3L, POLQ, POLA1, POLD1, POLG, POLE2, POLE, POLA2, POLD3, PAPD5, PRIMPOL, MYBBP1A, POLD4, POLE4, POLE3, CHRAC1, POLK, POLI, POLH |
GO:0003896 | MF | DNA primase activity | Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. |
POLA1, PRIM1, PRIM2, PRIMPOL |
GO:0003899 | MF | DNA-directed RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
POLR1C, POLR3G, CD3EAP, POLR2D, CRCP, POLR2E, POLR2A, POLR2I, POLR2J, POLR2G, POLR2L, MED21, POLR3C, POLR2J2, POLR3F, MED20, POLR3K |
GO:0003905 | MF | alkylbase DNA N-glycosylase activity | Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. |
MPG |
GO:0003906 | MF | DNA-(apurinic or apyrimidinic site) lyase activity | Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. |
HMGA2, NTHL1, ALKBH1, NEIL3 |
GO:0003909 | MF | DNA ligase activity | Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. |
LIG1 |
GO:0003910 | MF | DNA ligase (ATP) activity | Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). |
PARP1, LIG1, PARP2 |
GO:0003917 | MF | DNA topoisomerase type I activity | Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. |
TOP1 |
GO:0003918 | MF | DNA topoisomerase type II (ATP-hydrolyzing) activity | Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. |
TOP2A |
GO:0003920 | MF | GMP reductase activity | Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH. |
GMPR |
GO:0003921 | MF | GMP synthase activity | Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP. |
GMPS |
GO:0003922 | MF | GMP synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. |
GMPS |
GO:0003923 | MF | GPI-anchor transamidase activity | Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. |
PIGK, PIGT, PIGU |
GO:0003924 | MF | GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + phosphate. |
GTPBP10, RAB27B, RHOD, DDX3X, RAB29, OPA1, EIF5B, MFN2, DIRAS3, KRAS, TUBB4A, GNAI2, TUBB, GNAI3, RAP2A, RRAS, RALA, RALB, EEF2, RAC2, GSPT1, GNB3, RHOQ, ARF4, RAB3B, RAB5A, TUBG1, GNA11, GBP1, GBP2, TRIM23, NUDT1, GNL1, EIF2S3, ARL4D, GNAQ, RAB5C, RAB7A, RAB9A, RAB28, RAB27A, ARHGDIB, EIF5, GEM, RRAD, RAC3, CDC42, SRP54, RAB2A, RAB5B, RHOA, GNG11, RRAS2, RAB11A, RHOB, RAB1A, RAP1A, GNB1, GNB2, RAC1, GNAI1, GNG5, EEF1A1, TUBA1B, TUBA4A, TUBB4B, ARF1, ARF5, GNAS, GNA12, EEF1A2, ARHGAP5, TUBB3, RAB31, RAB32, TUBA3C, TUBB2A, RAB33A, RHEB, RAB11B, TSR1, GNAS, ATL3, GBP6, TUBA1A, RHOU, MMAA, ADSSL1, GTPBP8, GUF1, ATL2, RAB8B, RIT1, GTPBP3, RERG, ARL8A, RASD2, GFM1, MTG1, TUBB6, TUBB2B, GNL3, GBP3, TUBB1, RHOJ, MTG2, RRAGC, RRAGD, RAB6B, ARL8B, GNL3L, NKIRAS1, DNAJC27, TUBE1, TUBD1, RAB21, RAB22A, RAB23, RASD1, HBS1L, SAR1B |
GO:0003939 | MF | L-iditol 2-dehydrogenase activity | Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. |
SORD |
GO:0003943 | MF | N-acetylgalactosamine-4-sulfatase activity | Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. |
ARSB, GALNS |
GO:0003944 | MF | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity | Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose. |
NAGPA |
GO:0003945 | MF | N-acetyllactosamine synthase activity | Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. |
B4GALT4, B4GALT1 |
GO:0003950 | MF | NAD+ ADP-ribosyltransferase activity | Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. |
TNKS, PARP1, PARP6, PARP8, TNKS2, PARP11, PARP2 |
GO:0003951 | MF | NAD+ kinase activity | Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). |
NADK2 |
GO:0003952 | MF | NAD+ synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. |
NADSYN1 |
GO:0003954 | MF | NADH dehydrogenase activity | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. |
NDUFS8, NDUFS2, NDUFA13 |
GO:0003955 | MF | NAD(P)H dehydrogenase (quinone) activity | Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone. |
NQO1 |
GO:0003960 | MF | NADPH:quinone reductase activity | Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. |
CRYZL1, CRYZ |
GO:0003962 | MF | cystathionine gamma-synthase activity | Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate. |
CTH |
GO:0003963 | MF | RNA-3'-phosphate cyclase activity | Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. |
RTCA |
GO:0003968 | MF | RNA-directed RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template. |
POLR2A |
GO:0003972 | MF | RNA ligase (ATP) activity | Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). |
RTCB |
GO:0003973 | MF | (S)-2-hydroxy-acid oxidase activity | Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide. |
HAO2 |
GO:0003974 | MF | UDP-N-acetylglucosamine 4-epimerase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine. |
GALE |
GO:0003976 | MF | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. |
GNPTAB, GNPTG |
GO:0003977 | MF | UDP-N-acetylglucosamine diphosphorylase activity | Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. |
UAP1 |
GO:0003978 | MF | UDP-glucose 4-epimerase activity | Catalysis of the reaction: UDP-glucose = UDP-galactose. |
GALE |
GO:0003979 | MF | UDP-glucose 6-dehydrogenase activity | Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate. |
UGDH |
GO:0003980 | MF | UDP-glucose:glycoprotein glucosyltransferase activity | Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins. |
UGGT1 |
GO:0003983 | MF | UTP:glucose-1-phosphate uridylyltransferase activity | Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. |
UGP2 |
GO:0003985 | MF | acetyl-CoA C-acetyltransferase activity | Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. |
ACAT2 |
GO:0003986 | MF | acetyl-CoA hydrolase activity | Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). |
ACOT8, NUDT7, ACOT9 |
GO:0003987 | MF | acetate-CoA ligase activity | Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. |
ACSS3, ACSS2, ACSS1 |
GO:0003988 | MF | acetyl-CoA C-acyltransferase activity | Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. |
HADHB |
GO:0003989 | MF | acetyl-CoA carboxylase activity | Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. |
ACACB |
GO:0003993 | MF | acid phosphatase activity | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. |
ACPP, PPIP5K1, PXYLP1, ACP6, MINPP1 |
GO:0003994 | MF | aconitate hydratase activity | Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. |
ACO2 |
GO:0003995 | MF | acyl-CoA dehydrogenase activity | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
ACOX3, ACADSB, ACADVL, ACOX1, ACOX2 |
GO:0003997 | MF | acyl-CoA oxidase activity | Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. |
ACOX1, ACOX2 |
GO:0003998 | MF | acylphosphatase activity | Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. |
ACYP1 |
GO:0003999 | MF | adenine phosphoribosyltransferase activity | Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. |
APRT |
GO:0004000 | MF | adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3. |
ADA |
GO:0004003 | MF | ATP-dependent DNA helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. |
DDX3X, CHD1, CHD2, NBN, XRCC5, ERCC2, MCM4, MCM7, RECQL, MRE11A, BLM, G3BP1, MCM6, CHD4, CHD1L, FBXO18, GTF2H4, RAD50, RUVBL2 |
GO:0004004 | MF | ATP-dependent RNA helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix. |
DDX39A, DDX3X, DHX15, DHX16, DDX5, EIF4A1, G3BP1, EIF4A2, DDX46, DHX30, DHX32, DHX29, DHX40, DHX37, SUPV3L1, TDRD9, DDX54, DDX17, DDX27, DDX23, DDX24, DDX47, DHX36, DHX35, YTHDC2, DDX31, DDX28, DDX43, DDX20, DDX52, DDX49 |
GO:0004012 | MF | phospholipid-translocating ATPase activity | Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP. |
ATP8B1, ATP9A, ATP8B4, ATP11B |
GO:0004013 | MF | adenosylhomocysteinase activity | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. |
AHCY |
GO:0004014 | MF | adenosylmethionine decarboxylase activity | Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2). |
AMD1 |
GO:0004016 | MF | adenylate cyclase activity | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
ADCY3, ADCY9, ADCY7 |
GO:0004017 | MF | adenylate kinase activity | Catalysis of the reaction: ATP + AMP = 2 ADP. |
AK1, AK4, RAD50, AK8 |
GO:0004018 | MF | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity | Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. |
ADSL |
GO:0004019 | MF | adenylosuccinate synthase activity | Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. |
ADSS, ADSSL1 |
GO:0004020 | MF | adenylylsulfate kinase activity | Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate. |
PAPSS2 |