Search Geneontologies

Geneontologies

GO ID Ontology GO Term Term Definition Proteins

GO:0061656

MF

SUMO conjugating enzyme activity

Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue.

UBE2I

GO:0061665

MF

SUMO ligase activity

Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.

ZNF451

GO:0061676

MF

importin-alpha family protein binding

Interacting selectively and non-covalently with any member of the importin-alpha family.

GOLGA2, TPX2

GO:0061712

MF

tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase

Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine.

CDKAL1

GO:0061714

MF

folic acid receptor activity

Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis.

FOLR1

GO:0061752

MF

telomeric repeat-containing RNA binding

Interacting selectively and non-covalently with long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats.

KDM1A, HNRNPA1

GO:0070006

MF

metalloaminopeptidase activity

Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

MMP14, METAP2, MMP15, MMP16, NPEPPS, ERAP2, AOPEP, ERAP1, LNPEP, LOC440434

GO:0070008

MF

serine-type exopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

PREP, PREPL

GO:0070012

MF

oligopeptidase activity

Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.

NDEL1

GO:0070016

MF

armadillo repeat domain binding

Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation.

CNOT1, AXIN1, STRN3, CHD8, TCF7L2, STRN4

GO:0070025

MF

carbon monoxide binding

Interacting selectively and non-covalently with carbon monoxide (CO).

CBS

GO:0070026

MF

nitric oxide binding

Interacting selectively and non-covalently with nitric oxide (NO).

GSTP1, CBS

GO:0070034

MF

telomerase RNA binding

Interacting selectively and non-covalently with the telomerase RNA template.

DKC1, HNRNPC, SNRPB, SNRPD3, HNRNPU, NAF1, TEP1, NOP10, GAR1, SMG5

GO:0070037

MF

rRNA (pseudouridine) methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule.

EMG1

GO:0070039

MF

rRNA (guanosine-2'-O-)-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine.

MRM1

GO:0070051

MF

fibrinogen binding

Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.

THBS1, FBLN1

GO:0070052

MF

collagen V binding

Interacting selectively and non-covalently with a type V collagen trimer.

ECM2, THBS1

GO:0070053

MF

thrombospondin receptor activity

Combining with thrombospondin and transmitting the signal to initiate a change in cell activity.

F2, CD36, SDC4, CD47

GO:0070061

MF

fructose binding

Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose.

ALDOA, PFKL, SLC2A5

GO:0070063

MF

RNA polymerase binding

Interacting selectively and non-covalently with an RNA polymerase molecule or complex.

BIN1, CCNT1, CCNT2, PPIB, ZFP36, STOM, TAF10, PKN2, PABPN1, ANP32B, YTHDC2, RRN3, PHRF1

GO:0070064

MF

proline-rich region binding

Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.

APBB1, PRPF40A, PFN1, GHR, CSK, YAP1, ITSN1, GAREM1, CYLD, ABI2, BAIAP2L1

GO:0070080

MF

titin Z domain binding

Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.

ACTN2

GO:0070087

MF

chromo shadow domain binding

Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.

SP100, ATRX, CHAF1A, TRIM28, NIPBL

GO:0070095

MF

fructose-6-phosphate binding

Interacting selectively and non-covalently with fructose 6-phosphate.

PFKFB1, PFKL

GO:0070097

MF

delta-catenin binding

Interacting selectively and non-covalently with the delta subunit of the catenin complex.

PTPRJ, DACT3, DACT1

GO:0070119

MF

ciliary neurotrophic factor binding

Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor.

IL6R

GO:0070123

MF

transforming growth factor beta receptor activity, type III

Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.

TGFBR3

GO:0070139

MF

SUMO-specific endopeptidase activity

Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO.

SENP5

GO:0070180

MF

large ribosomal subunit rRNA binding

Interacting selectively and non-covalently with the large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.

RPLP1, RPLP2, RPLP0, RPL19, MRTO4

GO:0070181

MF

small ribosomal subunit rRNA binding

Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.

RPS14, RPS13, CIRBP, UTP23

GO:0070182

MF

DNA polymerase binding

Interacting selectively and non-covalently with a DNA polymerase.

CDK2AP1, HMGB1, PCNA, SMARCA4, RAD51, ACD, FANCD2, FANCI, SMG5

GO:0070251

MF

pristanate-CoA ligase activity

Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA.

SLC27A2

GO:0070260

MF

5'-tyrosyl-DNA phosphodiesterase activity

Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA.

TDP2

GO:0070273

MF

phosphatidylinositol-4-phosphate binding

Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.

SH3PXD2B, SNX3, OSBP, ARFIP1, OSBPL8, PLEKHA5, SNX24

GO:0070290

MF

N-acylphosphatidylethanolamine-specific phospholipase D activity

Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).

PLD1, NAPEPLD

GO:0070300

MF

phosphatidic acid binding

Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.

PLCD1, UQCC3, COMMD1, RAPGEF6, MAPKAP1, ATP13A2, MARK1, PITPNC1

GO:0070320

MF

inward rectifier potassium channel inhibitor activity

Stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.

CAV1

GO:0070324

MF

thyroid hormone binding

Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.

TTR, CTSH, THRA, ALDH1A3

GO:0070325

MF

lipoprotein particle receptor binding

Interacting selectively and non-covalently with a lipoprotein particle receptor.

APOA5

GO:0070326

MF

very-low-density lipoprotein particle receptor binding

Interacting selectively and non-covalently with a very-low-density lipoprotein receptor.

APOE, LRPAP1, PCSK9

GO:0070330

MF

aromatase activity

Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.

CYP1A1, CYP3A4, CYP2D6, CYP19A1, CYP3A5, CYP3A7, CYP1B1, CYP2U1, CYP3A43

GO:0070335

MF

aspartate binding

Interacting selectively and non-covalently with aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4.

CAD

GO:0070336

MF

flap-structured DNA binding

Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule.

FAN1

GO:0070363

MF

mitochondrial light strand promoter sense binding

Interacting selectively and non-covalently with the sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA.

TFAM

GO:0070401

MF

NADP+ binding

Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

GMDS

GO:0070402

MF

NADPH binding

Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

DHFR, HMGCR, QDPR, SRD5A1, FASN, CRYZ, DECR1, GRHPR

GO:0070403

MF

NAD+ binding

Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

HPGD, ALDH1A3, HADH, SIRT2, UXS1, CRYL1

GO:0070404

MF

NADH binding

Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

QDPR

GO:0070410

MF

co-SMAD binding

Interacting selectively and non-covalently with a common mediator SMAD signaling protein.

SMAD6, GATA4, SMAD3, SMAD2, SMAD1, CITED1, TRIM33

GO:0070411

MF

I-SMAD binding

Interacting selectively and non-covalently with an inhibitory SMAD signaling protein.

SMAD7, AXIN1, TGFB1I1, SMAD6, CTNNB1, TGFBR1, SMAD4, SMAD2, SMAD1

GO:0070412

MF

R-SMAD binding

Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.

SMAD6, FOS, JUN, PARP1, SMAD3, SMAD4, ANKRD1, SMAD2, ZC3H3, PMEPA1, RGCC, TRIM33

GO:0070463

MF

tubulin-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate.

KIF18A

GO:0070491

MF

repressing transcription factor binding

Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.

ARNTL, GMNN, MYC, EIF4E, HMGB1, SKI, SKIL, TCF3, NFYB, SRI, CTNNB1, CBX5, HDAC4, HHEX, RELA, HDAC1, RUNX2, HDAC7, DDX20, HDAC9, HDAC5, NOC2L

GO:0070492

MF

oligosaccharide binding

Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.

GYPC, SELE, DCBLD1, LOXL2

GO:0070506

MF

high-density lipoprotein particle receptor activity

Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis.

SCARB1

GO:0070513

MF

death domain binding

Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.

DAPL1, DAP, CRADD, RIPK1, TRADD

GO:0070524

MF

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+.

HSD11B1

GO:0070530

MF

K63-linked polyubiquitin binding

Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers.

TNFAIP3, SQSTM1, OTUD7B, FAAP20, RNF169, ATRIP, OPTN, ZRANB1

GO:0070538

MF

oleic acid binding

Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid.

FABP3, SCP2

GO:0070539

MF

linoleic acid binding

Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid.

PPARD

GO:0070551

MF

endoribonuclease activity, cleaving siRNA-paired mRNA

Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters.

AGO2

GO:0070573

MF

metallodipeptidase activity

Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

ACE, CPQ

GO:0070576

MF

vitamin D 24-hydroxylase activity

Catalysis of the hydroxylation of C-24 of any form of vitamin D.

CYP1A1, CYP3A4

GO:0070577

MF

lysine-acetylated histone binding

Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.

BRD4, BRD2, SMARCA4, PSME4, BRD3, CARM1, PHIP, BRD7, BAZ1B

GO:0070579

MF

methylcytosine dioxygenase activity

Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2.

ALKBH1

GO:0070611

MF

histone methyltransferase activity (H3-R2 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3.

PRMT6

GO:0070612

MF

histone methyltransferase activity (H2A-R3 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A.

PRMT6

GO:0070615

MF

nucleosome-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes.

SMARCA1

GO:0070626

MF

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

ADSL

GO:0070628

MF

proteasome binding

Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation.

UBD, PSMG1, ID1, ADRM1, USP13, UCHL5

GO:0070644

MF

vitamin D response element binding

Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.

VDR, TCF3

GO:0070653

MF

high-density lipoprotein particle receptor binding

Interacting selectively and non-covalently with a high-density lipoprotein receptor.

APOA1, APOA2, APOC3

GO:0070679

MF

inositol 1,4,5 trisphosphate binding

Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate.

TRPC1, TRPC3, ITPR2, ITPR3, ITPR1, PLCL1, TRPC6

GO:0070698

MF

type I activin receptor binding

Interacting selectively and non-covalently with a type I activin receptor.

SMAD6

GO:0070699

MF

type II activin receptor binding

Interacting selectively and non-covalently with a type II activin receptor.

INHBA, SYNJ2BP, MAGI2

GO:0070700

MF

BMP receptor binding

Interacting selectively and non-covalently with a BMP receptor.

BMP2, BMP4, BMP3, BMP6, BMP8B, BMP8A, PYCARD

GO:0070717

MF

poly-purine tract binding

Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule.

TRA2B

GO:0070728

MF

leucine binding

Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid.

GLUD2, SESN2, UBR1, SESN1

GO:0070733

MF

protein adenylyltransferase activity

Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins.

FICD

GO:0070740

MF

tubulin-glutamic acid ligase activity

Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.

TTLL1

GO:0070742

MF

C2H2 zinc finger domain binding

Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.

WT1, HMGA2, EHMT2, SRRM2

GO:0070780

MF

dihydrosphingosine-1-phosphate phosphatase activity

Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate.

SGPP2

GO:0070815

MF

peptidyl-lysine 5-dioxygenase activity

Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2.

JMJD6

GO:0070840

MF

dynein complex binding

Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.

CCDC42B, TPR, HDAC6

GO:0070851

MF

growth factor receptor binding

Interacting selectively and non-covalently with a growth factor receptor.

APP, FYN

GO:0070856

MF

myosin VI light chain binding

Interacting selectively and non-covalently with a light chain of a myosin VI complex.

IQGAP3

GO:0070878

MF

primary miRNA binding

Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.

SMAD1, EZH2

GO:0070883

MF

pre-miRNA binding

Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.

DICER1

GO:0070888

MF

E-box binding

Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.

ARNTL, BHLHE40, PER1, TCF21, MYC, TCF4, TCF3, TAL1, LMO2, AHR, ZEB1, ASCL1, SREBF2, TWIST1, ARNTL2, ATOH8, TCF12

GO:0070890

MF

sodium-dependent L-ascorbate transmembrane transporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in).

SLC23A2

GO:0070891

MF

lipoteichoic acid binding

Interacting selectively and non-covalently with lipoteichoic acid.

CD14, CD6

GO:0070892

MF

lipoteichoic acid receptor activity

Combining with lipoteichoic acid and transmitting the signal to initiate a change in cell activity.

CD36

GO:0070905

MF

serine binding

Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid.

SHMT1, THNSL2

GO:0070974

MF

POU domain binding

Interacting selectively and non-covalently with a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors.

AR

GO:0070975

MF

FHA domain binding

Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich.

MDC1

GO:0070984

MF

SET domain binding

Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation.

WIZ

GO:0070990

MF

snRNP binding

Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle.

PRPF31

GO:0070996

MF

type 1 melanocortin receptor binding

Interacting selectively and non-covalently with a type 1 melanocortin receptor.

POMC, MRAP, MRAP2

GO:0071074

MF

eukaryotic initiation factor eIF2 binding

Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.

EIF5

GO:0071207

MF

histone pre-mRNA stem-loop binding

Interacting selectively and non-covalently with a conserved stem-loop structure found in histone pre-mRNAs.

SLBP

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