GO:0042800

MF

histone methyltransferase activity (H3-K4 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.

RBBP5, KMT2E, KMT2C, ASH1L, ASH2L, KMT2B

GO:0042802

MF

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

PLK4, SDCBP, CLDN4, AXIN1, MID1, KDM6A, CLDN3, SSNA1, BNIP3L, PARK2, SRPX2, VPS4B, PRKRA, USP2, BRI3, CLDN1, LDHA, GOT2, EGFR, SERPINA1, CST3, LDLR, GCG, INS, TNF, COL1A1, CRYAB, APOA1, APOE, TTR, ALB, FTL, ESR1, VTN, ALDOA, PRNP, CD74, S100B, VWF, ERBB2, TP53, HSPB1, APP, ITGB3, JUN, LDHB, HSP90AA1, HNRNPC, THBS1, COL1A2, INHBA, VIM, FBP1, ANXA4, CCL3, CD28, IAPP, FGFR1, G6PD, PCNA, CCL4, ALAD, LCP1, DRD2, ACPP, NME1, NQO1, VEGFA, PFKFB1, DES, PFKL, NFKB1, NPR2, GSTM3, SYT1, PAICS, FBLN1, PTPRG, AHCY, MPST, PTX3, S100A4, PLN, DPP4, CAD, MAPK1, S100A2, EPHB2, GBP1, ACTN2, TRIM23, SNCA, RBMX, CSK, EPS15, FHIT, NUP153, SEPHS1, CPT1A, DAPK1, CTSC, ATXN3, ATXN1, BCAT1, EPHA4, ALDH18A1, VCP, CASP6, SNX16, PTEN, ACTB, PSME3, LYZ, STXBP1, B2M, GRB2, DYNLT1, GPSM2, SORD, PLIN5, CAV1, RELA, TLE1, ZBTB16, FMR1, PRDX1, BAX, KCNH2, BNIP3, TARDBP, FADD, SMAD4, SQSTM1, RIPK1, PKD2, TP53BP2, PAFAH1B3, PCM1, TRIP10, TRIP13, MAPRE1, SMAD1, ADIPOQ, CLPP, UGP2, KLHL12, CDC42BPA, ATL3, DESI1, RGMB, JMJD6, CBLL1, SETX, SDK1, CCDC91, ADIPOR2, HOOK3, ZDHHC17, PHYKPL, PLEKHH2, SCUBE1, KLHL7, AMOTL1, SFRP1, HJURP, MNS1, TRPV1, ATL2, PPP1R13L, KCTD13, TTN, TOPBP1, TFG, RYR2, ADIPOR1, DACT3, OPTN, YIPF6, HOOK2, EDC3, UHRF1, CCT7, CORO1B, SDF4, NIF3L1, CHMP4B, DCTPP1, C10orf88, SMURF2, ROBO2, TRIM39, RAD18, MTPAP, THAP1, NDE1, ATXN10, NUFIP1, PYCARD, PRPF19, MAPRE3, MAPK8IP1, RUVBL2, SH3GLB1, L3MBTL1, USP15, TNPO3, FHOD1, SNCAIP

GO:0042803

MF

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

E2F8, ACOT7, SDCBP, PDXK, BHLHE40, KCNK3, ADAM10, AXIN1, GSTA4, SLC22A1, GRM6, MID1, TOX3, FOXP2, IRAK2, MAP3K13, DAPK3, RIPK2, TBX1, ACTN4, GSTZ1, NUDT21, BNIP3L, RAB11FIP3, PDCD6, VPS4B, ERN1, BANF1, PRKRA, LRP6, IDH1, STC2, RNF8, SLIT2, TRIM37, VAPB, PEX11B, GOT2, PDGFB, TGFB1, CD4, CRYAB, APOE, APOA2, AMBP, TFRC, ANG, HMGCR, ANXA1, PDGFA, S100B, VWF, NTRK1, TYMS, JUN, S100A6, NPM1, CSF1R, ADRB2, HSP90AA1, ANXA6, ASNS, IL6R, SNRPC, LGALS1, QDPR, GSTM1, INHBB, HMOX1, BCL2, MGST1, KIT, GHR, FGFR1, TOP2A, G6PD, PRPS2, ODC1, TPR, ACTN1, CCL5, ENO3, ADRB3, DRD2, TYR, IDE, JUP, PVR, HPGD, VEGFA, TCF4, RAG1, TCF3, PDGFRA, PRLR, NPR3, CEBPB, HLA-G, RPL7, ATF3, SRM, NFKB1, GSTM3, FLNA, AGXT, FGFR2, ERBB3, ENPP1, XPA, CBLN1, SP100, NR2F2, TARS, STOM, PON1, MAOB, DPP4, DCK, GSTM2, ABCD3, MZF1, IMPA1, TKT, ERP29, CLIP1, CORO1A, S100A11, SHMT1, RDX, PTGS2, CBS, MYH9, ACTN2, CHKA, HMGCL, CHRNA7, CPOX, BMPR1A, IL6ST, ID1, CD200, NBL1, ECE1, MSH2, NR4A2, NAMPT, CBX5, ALDH1A3, XDH, SLC11A1, FASN, CENPF, PCYT1A, HARS2, CEBPD, PGF, VEGFB, TSC2, ASCL1, FXR1, IRAK1, CAV2, HSD17B4, PSMD7, CLCN3, NR0B1, GTF2A2, HRSP12, CEBPG, MVD, TERF1, GYS2, CDH13, TPD52, OXCT1, CTBP2, TIRAP, PRPS1, S100A10, TGFB2, RACK1, PAFAH1B2, ABAT, CBX1, SMAD3, NDP, HMGCS1, PLOD1, GSTM4, HHEX, RELA, ACVR1, ZBTB16, FMR1, BAX, MCL1, SMAGP, BST2, KCNH2, DPYD, BNIP3, STK4, CALCOCO2, PRDX4, MAD2L1, SMAD4, SQSTM1, CAMK2D, PKD2, TDG, SNX1, MTMR1, MTMR2, CUL3, GALE, HES1, MEF2D, EEA1, NECTIN1, PPP2R4, QPRT, RABEP1, ERBB4, NR0B2, TWIST1, ELAVL1, SMAD2, SMAD1, ADIPOQ, USF2, EXT1, NTRK2, KYNU, PTPRO, AOC3, TPD52L1, LRRFIP1, CCDC88A, NADK2, ANO6, MLK4, OLFML2A, TENM4, JMJD6, SLC27A1, MTHFD1L, OLFM4, RBPMS2, RAB11FIP2, EMSY, SLC51A, SPATA24, CARM1, CEP57, CCDC103, SLC30A8, KLHL7, SUPV3L1, NLGN4X, ADSSL1, CISD2, COMMD1, FAM73A, ZBTB38, SUMF1, UXS1, LILRB1, GABPB2, SPPL3, SPPL2A, HM13, SCARB1, PDCD6IP, MITD1, NR4A3, BCL2L2, RBPMS, NUDT16, S100A16, DGAT2, ALS2, KIF20B, TCF12, P2RX4, S100A13, MAP3K5, MGLL, BARD1, ARID3A, CITED1, TREX2, SYT11, PDCD10, JAM3, CADM1, TRIM8, FOXP3, TRIM9, MFF, DNTTIP1, SDCBP2, IKZF4, MUC13, CHMP4B, GLIPR2, GREM2, ECT2, GRPEL1, CACYBP, APOBEC3G, GOPC, PLCB1, HEYL, ANO2, HPS4, NECTIN3, PRDM6, PDGFC, PRTFDC1, ABCB10, FGFR1OP2, MTPAP, CLN6, FLRT3, ZBTB4, TENM3, GRHPR, PLEKHB1, MLX, GNPTG, NUDT5, ACSL6, BLOC1S6, FZD4, PYCARD, BOK, STUB1, SNX6, TIMELESS, CRYL1, SH3GLB1, SNX9, IRAK3, CPQ

GO:0042805

MF

actinin binding

Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.

NFKB1, RELA, PKD2, TTN, PDLIM5, TRPC6

GO:0042809

MF

vitamin D receptor binding

Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.

MED14, TOB2, TAF11, MED12, MED30, MED4, MED17, THRAP3, MED16

GO:0042813

MF

Wnt-activated receptor activity

Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.

FZD6, FZD7, LRP5, LRP6, SFRP5, SFRP4, SFRP1, FZD8, FZD4

GO:0042826

MF

histone deacetylase binding

Interacting selectively and non-covalently with the enzyme histone deacetylase.

HDAC3, ZNHIT1, KLF4, TCF21, NUDT21, PARK2, NCOR1, GMNN, HSP90AA1, HSP90AB1, PARP1, HSPA1A, HSPA1B, GLI3, TOP2A, TAL1, CEBPB, XBP1, SFPQ, YY1, HOXA10, YWHAB, PHB, CBX5, MAPK8, NRIP1, KPNA2, HDAC4, YWHAE, RAC1, INSM1, MEF2A, RELA, MEF2C, RBBP4, CDC20, HDAC1, HNRNPD, HES1, MEF2D, ANKRD1, PKN1, PKN2, CRY1, HIF1A, BRMS1L, NIPBL, SIRT2, KAT2B, RAD9A, FOXP3, DHX36, SUDS3, DACT1, DNMT3B, HDAC6, DDX20, HDAC9, SMG5, HDAC5, NCOR2

GO:0042834

MF

peptidoglycan binding

Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

TLR2, PGLYRP2

GO:0042903

MF

tubulin deacetylase activity

Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate.

SIRT2, HDAC6

GO:0042910

MF

xenobiotic transporter activity

Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells.

SLC2A1

GO:0042922

MF

neuromedin U receptor binding

Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor.

NMU

GO:0042923

MF

neuropeptide binding

Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).

SSTR1, MC4R, SSTR5, OPRL1, ADCYAP1R1, NPBWR1

GO:0042931

MF

enterobactin transporter activity

Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells.

ASIC3

GO:0042954

MF

lipoprotein transporter activity

Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells.

LRP2

GO:0042974

MF

retinoic acid receptor binding

Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.

CNOT1, ACTN4, HMGA1, CTBP2, LRIF1

GO:0042975

MF

peroxisome proliferator activated receptor binding

Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.

HMGA1, MDM2, NFATC4, NR0B2, ASXL2, PPARGC1A

GO:0042978

MF

ornithine decarboxylase activator activity

Upregulation of the activity of the enzyme ornithine decarboxylase.

AZIN1, PRLR

GO:0042988

MF

X11-like protein binding

Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein.

CLSTN1

GO:0043008

MF

ATP-dependent protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP.

PRNP, PLK2, SAE1

GO:0043014

MF

alpha-tubulin binding

Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.

WASH1, OFD1, SNCA, NCALD, FAM110C, HSPH1, ARL8A, PACRG, NDEL1, RACGAP1, TRPV4, ARL8B, PPARGC1A, HDAC6, SPAST

GO:0043015

MF

gamma-tubulin binding

Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin.

OFD1, RAD51D, LYN, NME1, BRCA2, MZT1, DIXDC1, CEP57, PIFO, NDRG1, TUBGCP3, MARK4, FEZ1, RACGAP1

GO:0043021

MF

ribonucleoprotein complex binding

Interacting selectively and non-covalently with any complex of RNA and protein.

PPIH, PQBP1, CD2BP2, SRP54, PPP1CA, HNRNPU, RNASEL, BOP1, EZH2, TIMM50, UHMK1, PRPF31, SECISBP2L, ITCH, SECISBP2, WDR12, SMG5

GO:0043022

MF

ribosome binding

Interacting selectively and non-covalently with any part of a ribosome.

LETM1, EIF2S1, RPSA, HSPA5, EEF2, EIF6, SEC61A1, EIF5A, FMR1, ICT1, CPEB4, LETM2, LETMD1, RICTOR, CPEB2, GUF1, CPEB3, GCN1, NAA15, YTHDF1, EIF5A2, MTIF3, C12orf65, SEC61A2, IMPACT, EIF3K, SBDS

GO:0043023

MF

ribosomal large subunit binding

Interacting selectively and non-covalently with any part of the larger ribosomal subunit.

NPM1, EIF6, CPEB2, MALSU1

GO:0043024

MF

ribosomal small subunit binding

Interacting selectively and non-covalently with any part of the small ribosomal subunit.

DDX3X, NPM1, NME1, EIF4B, ABCE1, DHX29, CPEB2, PTCD3, MTIF3

GO:0043027

MF

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.

NOL3, MT3, CD27, SNCA, SERPINB9, XIAP, BIRC3, GAS6, RPS6KA1

GO:0043028

MF

cysteine-type endopeptidase regulator activity involved in apoptotic process

Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.

FOXL2

GO:0043047

MF

single-stranded telomeric DNA binding

Interacting selectively and non-covalently with single-stranded telomere-associated DNA.

HNRNPA2B1, RAD50, OBFC1, POT1

GO:0043120

MF

tumor necrosis factor binding

Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.

A2M

GO:0043121

MF

neurotrophin binding

Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.

NTRK1, NTRK2

GO:0043125

MF

ErbB-3 class receptor binding

Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3.

ERBB2, PIK3R1, CDK5, NRG1

GO:0043130

MF

ubiquitin binding

Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

UBAP1L, BUB3, PARK2, UBXN7, UBR5, BCL10, HSPB1, UCHL1, TOP2A, IDE, UCHL3, TNFAIP3, CKS2, NUP62, UBE2A, TERF1, CKS1B, CXCR4, RAE1, SMAD3, SQSTM1, NBR1, CRY1, RHBDD2, FAAP20, TP53INP2, SIRT2, KIF18A, DYRK2, USP13, FAF2, OTUB2, MVB12A, OTUB1, MARK4, RNF216, USP25, FAF1, NSFL1C, FAN1

GO:0043138

MF

3'-5' DNA helicase activity

Catalysis of the unwinding of the DNA helix in the direction 3' to 5'.

GINS1, FBXO18, GINS4, GINS2

GO:0043139

MF

5'-3' DNA helicase activity

Catalysis of the unwinding of the DNA helix in the direction 5' to 3'.

ERCC2, DNA2, PEO1

GO:0043140

MF

ATP-dependent 3'-5' DNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'.

RECQL4, RECQL, BLM, ASCC3

GO:0043141

MF

ATP-dependent 5'-3' DNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.

PIF1, RUVBL2, RUVBL1

GO:0043142

MF

single-stranded DNA-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction.

POLQ, RFC4, RFC2, RFC5, RFC3, DNA2, RAD51, CHTF18, DSCC1, RAD18

GO:0043169

MF

cation binding

Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.

PARN, GBE1

GO:0043175

MF

RNA polymerase core enzyme binding

Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme.

SCAF8

GO:0043177

MF

organic acid binding

Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage.

HMGCS1

GO:0043183

MF

vascular endothelial growth factor receptor 1 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1.

VEGFA

GO:0043184

MF

vascular endothelial growth factor receptor 2 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.

GREM1, ITGB3, ITGA5, VEGFA, PDCL3

GO:0043185

MF

vascular endothelial growth factor receptor 3 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3.

VEGFC

GO:0043208

MF

glycosphingolipid binding

Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.

LYN, SELL

GO:0043225

MF

ATPase-coupled anion transmembrane transporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in).

ABCC4, ABCC5, CFTR, ABCC1, ABCC10

GO:0043236

MF

laminin binding

Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.

ITGB1, THBS1, RPSA, LGALS1, NID1, ITGA2, LGALS3, ITGA6, CTSS, ITGA3, GPC1, BCAM, ADAM9, ITGA9, TINAGL1, PLEKHA2

GO:0043237

MF

laminin-1 binding

Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.

SLIT2, NID1, DAG1, NTN4

GO:0043262

MF

adenosine-diphosphatase activity

Catalysis of the reaction: ADP + H2O = AMP + phosphate.

NUDT9

GO:0043273

MF

CTPase activity

Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction.

DDX3X

GO:0043274

MF

phospholipase binding

Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.

PARK2, SELE, LMNB1, SNCA, CALM2, PTPN11

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

PTGES, GSTP1, GSTM1, MGST1, GSTM3, GSTM2, GSTM4

GO:0043325

MF

phosphatidylinositol-3,4-bisphosphate binding

Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.

MYO1G, AKT1, COMMD1, ARAP3, MAPKAP1, ZFYVE1, ADAP2

GO:0043337

MF

CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity

Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol.

CRLS1

GO:0043394

MF

proteoglycan binding

Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

SLIT2, CTSL, CTSB, THBS1, NID1, COL5A1, CTSS, COL5A3, CTSK, FCN2

GO:0043395

MF

heparan sulfate proteoglycan binding

Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.

GPC4, CFH, FST, GPC1, COMP, SEMA5A, GPC2, HPSE, GPC6

GO:0043398

MF

HLH domain binding

Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.

UBE2I, PKD2

GO:0043422

MF

protein kinase B binding

Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism.

BCL10, SRSF1, SRSF5, PDE3B, CCDC88A, BAD, PINK1

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

BHLHE40, TCF21, TCF4, TCF3, LMO2, SOX9, ASCL1, SMAD3, RUNX2, TWIST1, USF2, TCF12, IKZF4

GO:0043426

MF

MRF binding

Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.

BHLHE40, KDM1A, CREBBP, TSC22D3

GO:0043492

MF

ATPase activity, coupled to movement of substances

Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance.

ASNA1, RALBP1

GO:0043495

MF

protein anchor

Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane.

PDCD6, MYH9, NUP153, AKAP6, CIB1

GO:0043515

MF

kinetochore binding

Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached.

CENPE, SPDL1, CENPH

GO:0043522

MF

leucine zipper domain binding

Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.

DAPK3, ATF4, DDIT3, ERC1, PAWR, CDC5L, AATF

GO:0043531

MF

ADP binding

Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.

ERN1, CYB5R3, ATP5D, MYH9, MSH2, GCLC, GLUD2, MSH6, PRKAG1, VCP, PRPS1, MYO9B, CHORDC1, MYO6

GO:0043532

MF

angiostatin binding

Interacting selectively and non-covalently with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis.

AMOT

GO:0043533

MF

inositol 1,3,4,5 tetrakisphosphate binding

Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate.

ADAP1, ITPR3, ADAP2

GO:0043539

MF

protein serine/threonine kinase activator activity

Binds to and increases the activity of a protein serine/threonine kinase.

SPRY2, TGFB1, IGF2, MAP2K2, IQGAP1, CALM2, MAP2K1, STK4, ALS2, CAB39

GO:0043544

MF

lipoamide binding

Interacting selectively and non-covalently with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.

DLD

GO:0043546

MF

molybdopterin cofactor binding

Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.

XDH, SUOX, AOX1, MARC1

GO:0043548

MF

phosphatidylinositol 3-kinase binding

Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.

IRS4, JAK2, DAB1, INSR, FYN, IGF1R, PDGFRB, PIK3R1, CORO1A, IRS1, CALM2, TYRO3, IRS2

GO:0043559

MF

insulin binding

Interacting selectively and non-covalently with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.

INSR, IGF1R, HSPD1, IDE, PIK3R1

GO:0043560

MF

insulin receptor substrate binding

Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.

JAK2, INSR, IGF1R, PIK3R1, PIK3CA, PIK3CB, GRB2, PRKCD, PTPN11

GO:0043565

MF

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

ARNTL, FOXN3, NR5A2, ZNF213, FOXP2, MAFG, ZSCAN9, HOXA3, TBX1, FOXO3, SNAI2, CREBL2, EDF1, SHOX2, MAF, ZNF205, WHSC1, TP53, CENPB, HOXC4, GLI2, BCL2, NR2F1, VDR, ESRRA, POU2F1, ETS1, HIVEP1, RAG1, ZNF24, ZKSCAN1, ATF7, EGR1, ATF4, WT1, NR4A1, NR2F2, NFYB, ARNT, HOXD10, HOXA6, HIVEP2, FOXN2, RORA, SOX6, PPARG, PBX2, BCL6, GATA4, NOTCH1, HOXA1, MEOX1, LHX2, ERF, NR0B1, CEBPG, FOXG1, HDAC4, MTPN, IRX3, SMAD3, FOXO4, ZNF200, E2F1, POU5F1, MEF2A, CREB5, HHEX, POU3F1, PPARD, EMX2, PPARA, FOXM1, FOXO1, TFCP2, FOXC1, NR1H3, TRIM28, SMAD4, CUX1, HES1, TSN, USF2, SNAPC1, HIF1A, ZSCAN26, ZSCAN23, HIVEP3, ZNF449, CXXC5, ZBTB33, ZSCAN30, CREBRF, FOXP4, ZNF397, CTCFL, GATAD1, CSRNP3, HDAC2, CREB3L1, ZNF274, ZSCAN31, NR1H4, CSRNP1, CDC5L, MEIS3, HNRNPAB, EPAS1, MYBBP1A, SALL3, FOXP3, CSRNP2, IKZF4, FOXP1, SOX17, ZNF532, TCF7L1, TCF7L2, THAP1, SLTM, GRHL1, ZBTB4, RERE, PPARGC1A, MAFF, FOXJ3, ZNF148, KLF2, CHCHD2, CAMTA1

GO:0043566

MF

structure-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding.

ERCC1, TDG, ERCC4

GO:0043621

MF

protein self-association

Interacting selectively and non-covalently with a domain within the same polypeptide.

BCL10, TP53, SLC2A1, CCL5, AGXT, TNFAIP3, ACVR2A, ABCD3, MDH2, ID1, CTSC, ATXN1, VAMP2, ADAM8, S100A7A, PCSK9, SVIP, TTN, RYR2, TMEM43, FOXP1, ZNF639

GO:0043734

MF

DNA-N1-methyladenine dioxygenase activity

Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.

FTO

GO:0043754

MF

dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity

Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine.

DBT

GO:0043783

MF

oxidoreductase activity, oxidizing metal ions with flavin as acceptor

Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor.

ETFDH

GO:0043795

MF

glyceraldehyde oxidoreductase activity

Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor.

AKR1B1

GO:0043812

MF

phosphatidylinositol-4-phosphate phosphatase activity

Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate.

SYNJ1

GO:0043813

MF

phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate.

SYNJ2, SYNJ1, PIKFYVE

GO:0043849

MF

Ras palmitoyltransferase activity

Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins.

ZDHHC9

GO:0043890

MF

N-acetylgalactosamine-6-sulfatase activity

Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.

GALNS

GO:0043914

MF

NADPH:sulfur oxidoreductase activity

Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+.

MICAL2

GO:0043916

MF

DNA-7-methylguanine glycosylase activity

Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site.

MPG

GO:0043924

MF

suramin binding

Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms.

RYR2

GO:0043995

MF

histone acetyltransferase activity (H4-K5 specific)

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5).

OGT, PHF20, KANSL3

GO:0043996

MF

histone acetyltransferase activity (H4-K8 specific)

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8).

OGT, PHF20, KANSL3

GO:0044020

MF

histone methyltransferase activity (H4-R3 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4.

PRMT6, PRMT1

GO:0044183

MF

protein binding involved in protein folding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding.

CLGN, CD74, HSPA1A, HSPA1B, CALR, CCT6A, CCT3, CCT2, PDCL3

GO:0044212

MF

transcription regulatory region DNA binding

Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.

NR5A2, SMAD7, KLF4, SMAD6, KDM1A, CCNT1, TBL1X, ZNF217, H2AFY, NCOR1, FOS, TNF, TP53, JUN, AR, THRA, EGR2, XRCC5, HNRNPL, HIVEP1, JUND, TAL1, ATF3, ATF4, TFEB, WT1, NFKB1, NR1D1, HNF1A, SFPQ, NFYB, YY1, HMGB2, MZF1, HIVEP2, CTNNB1, PHB, DDIT3, SOX6, AHR, PPARG, SNCA, BRCA1, STAT3, ETV5, WNT5A, GATA4, NKX2-1, YAP1, SMARCA2, DLX5, HDAC4, SMAD3, ZNF200, HHEX, RELA, MEF2C, GABPA, PAX8, FOXC1, NR1H3, IKZF1, SMAD4, HDAC1, NFYC, ARID5B, RBBP5, ERBB4, TAF5, ARID4B, HIVEP3, CARM1, ZNF567, ZNF513, CTCFL, GABPB2, ZNF564, GLMP, PROX1, GATA6, CREB3L1, ZNF382, TCF12, CDC5L, CITED1, SALL3, TBL1XR1, IKZF4, DHX36, ZNF335, SOX17, TAF9B, ZNF532, TCF7L1, BRD7, TCF7L2, GRHL1, H2AFY2, RCOR3, ASH2L, TCF20, ZNF639, KLF15, HDAC5

GO:0044213

MF

intronic transcription regulatory region DNA binding

Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within.

NKX2-1

GO:0044323

MF

retinoic acid-responsive element binding

Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind.

NR2F1

GO:0044325

MF

ion channel binding

Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

FXYD1, ACTN4, PRNP, FYN, HSP90AA1, LYN, HSP90AB1, TRAPPC2, ACTN1, PRKCSH, TSPO, SRI, CDH5, CTNNB1, ACTN2, HTT, S100A10, FGF12, CALM2, YWHAE, PKD1, ANK2, ID2, CAV1, YWHAH, FMR1, PDE4D, ANK3, DLG1, AKAP6, SNTA1, CAMK2D, PKD2, FHL1, KCNJ11, GRINA, HOMER1, CHERP, KCNE4, RYR2, FGF13, AP2M1, NEDD4L, PANX1, CIB1, PKP2, RIMS4, GOPC, RANGRF, PHPT1, KCNIP2, PYCARD, RIMS2, TCAF1

GO:0044377

MF

RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.

CEBPG

GO:0044378

MF

non-sequence-specific DNA binding, bending

The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.

HMGB2

GO:0044389

MF

ubiquitin-like protein ligase binding

Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.

CEBPB, XBP1, VCP, USP13

GO:0044540

MF

L-cystine L-cysteine-lyase (deaminating)

Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide.

CTH

GO:0044548

MF

S100 protein binding

Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.

KCNK3, S100B, S100A6, ANXA2, EZR, ATP2A2, S100A11, IQGAP1, ANXA11, AHNAK

GO:0044594

MF

17-beta-hydroxysteroid dehydrogenase (NAD+) activity

Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+.

HSD17B4