| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0035662 | MF | Toll-like receptor 4 binding | Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. |
S100A8, S100A9, TIRAP |
GO:0035663 | MF | Toll-like receptor 2 binding | Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response. |
TIRAP, TLR1 |
GO:0035718 | MF | macrophage migration inhibitory factor binding | Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor. |
CD74 |
GO:0035727 | MF | lysophosphatidic acid binding | Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G-protein-coupled receptors. |
GAP43 |
GO:0035730 | MF | S-nitrosoglutathione binding | Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems. |
GSTP1 |
GO:0035731 | MF | dinitrosyl-iron complex binding | Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO. |
GSTP1 |
GO:0035800 | MF | deubiquitinase activator activity | Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences. |
VCP, TANK |
GO:0035851 | MF | Krueppel-associated box domain binding | Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors. |
TRIM28 |
GO:0035870 | MF | dITP diphosphatase activity | Catalysis of the reaction: dITP + H2O = dIMP + diphosphate. |
NUDT16 |
GO:0035877 | MF | death effector domain binding | Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD). |
NOL3, FADD, CASP8 |
GO:0035925 | MF | mRNA 3'-UTR AU-rich region binding | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule. |
ZFP36, ZFP36L2, ZFP36L1, CPSF1, HNRNPD, ELAVL1, CPEB2, CPEB3, KHSRP |
GO:0035939 | MF | microsatellite binding | Interacting selectively and non-covalently with a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem. |
HEYL, HEY1 |
GO:0036002 | MF | pre-mRNA binding | Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. |
DDX5, PTBP1, TRA2B, SRSF2, SRSF6, RBM22, PTBP2 |
GO:0036004 | MF | GAF domain binding | Interacting selectively and non-covalently with the GAF domain of a protein. |
AIP |
GO:0036033 | MF | mediator complex binding | Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
SMC1A, NIPBL, SMC3 |
GO:0036041 | MF | long-chain fatty acid binding | Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
FABP3, HRSP12 |
GO:0036042 | MF | long-chain fatty acyl-CoA binding | Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. |
ACOT7, DBI, SCP2 |
GO:0036094 | MF | small molecule binding | Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule. |
AMBP, PAEP, PTGDS, LCN2 |
GO:0036122 | MF | BMP binding | Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family. |
GREM1, NBL1, GDF5, BMPR2, GREM2 |
GO:0036130 | MF | prostaglandin H2 endoperoxidase reductase activity | Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate). |
AKR1C3 |
GO:0036131 | MF | prostaglandin D2 11-ketoreductase activity | Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+. |
AKR1C3 |
GO:0036132 | MF | 13-prostaglandin reductase activity | Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin. |
PTGR1 |
GO:0036143 | MF | kringle domain binding | Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors. |
CLEC3B |
GO:0036219 | MF | GTP diphosphatase activity | Catalysis of the reaction: GTP + H2O = GMP + diphosphate. |
NUDT1 |
GO:0036310 | MF | annealing helicase activity | Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between strands. Often acts on ssDNA bubbles bound by replication protein A (RPA). |
RECQL4, ANXA1, SMARCA1, RECQL, BLM, RAD54L |
GO:0036312 | MF | phosphatidylinositol 3-kinase regulatory subunit binding | Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. |
XBP1, PIK3R1, FBXL2 |
GO:0036317 | MF | tyrosyl-RNA phosphodiesterase activity | Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. |
TDP2 |
GO:0036374 | MF | glutathione hydrolase activity | Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. |
GGT7 |
GO:0036402 | MF | proteasome-activating ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. |
PSMC3, PSMC2, PSMC4, PSMC1, PSMC6 |
GO:0036435 | MF | K48-linked polyubiquitin binding | Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers. |
VCP, UFD1L |
GO:0036458 | MF | hepatocyte growth factor binding | Interacting selectively and non-covalently with a hepatocyte growth factor. |
SRPX2 |
GO:0036459 | MF | thiol-dependent ubiquitinyl hydrolase activity | Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin. |
USP53, USP54, ALG13 |
GO:0036461 | MF | BLOC-2 complex binding | Interacting selectively and non-covalently with a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. |
RAB32 |
GO:0036487 | MF | nitric-oxide synthase inhibitor activity | Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase. |
ATP2B4 |
GO:0036505 | MF | prosaposin receptor activity | Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D). |
GPR37 |
GO:0038021 | MF | leptin receptor activity | Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
LEPR |
GO:0038023 | MF | signaling receptor activity | Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
OR51E2 |
GO:0038024 | MF | cargo receptor activity | Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis. |
DAB2 |
GO:0038025 | MF | reelin receptor activity | Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
VLDLR |
GO:0038036 | MF | sphingosine-1-phosphate receptor activity | Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. |
S1PR1, S1PR3, SPHK1 |
GO:0038049 | MF | transcription factor activity, ligand-activated RNA polymerase II transcription factor binding | Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements. |
NOTCH2 |
GO:0038051 | MF | glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity | Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, glucocorticoid-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain glucocorticoid response elements. |
NR3C1 |
GO:0038052 | MF | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
ESR1, ESR2 |
GO:0038062 | MF | protein tyrosine kinase collagen receptor activity | Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
DDR1 |
GO:0038064 | MF | collagen receptor activity | Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
ITGA2, ITGA11 |
GO:0038085 | MF | vascular endothelial growth factor binding | Interacting selectively and non-covalently with a vascular endothelial growth factor. |
NRP1, PDGFRB, PDGFRA |
GO:0038106 | MF | choriogonadotropin hormone binding | Interacting selectively and non-covalently with choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit. |
LHCGR |
GO:0038132 | MF | neuregulin binding | Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors. |
ITGB3, ITGAV, ITGB4, ERBB3, ITGA6 |
GO:0038181 | MF | bile acid receptor activity | Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile. |
NR1H4 |
GO:0038186 | MF | lithocholic acid receptor activity | Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity. |
VDR |
GO:0038191 | MF | neuropilin binding | Interacting selectively and non-covalently with a member of the neuropilin family. |
SEMA3E, SEMA7A, SEMA3D, SEMA3B, SEMA3A, SEMA3C |
GO:0039552 | MF | RIG-I binding | Interacting selectively and non-covalently with RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA. |
SEC14L1 |
GO:0039706 | MF | co-receptor binding | Interacting selectively and non-covalently with a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell. |
DKK1, BMP2, BMP4, HFE, DKK2, TFR2 |
GO:0042008 | MF | interleukin-18 receptor activity | Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL18R1 |
GO:0042015 | MF | interleukin-20 binding | Interacting selectively and non-covalently with interleukin-20. |
IFNGR1, IFNAR2 |
GO:0042019 | MF | interleukin-23 binding | Interacting selectively and non-covalently with interleukin-23. |
IL12RB1 |
GO:0042020 | MF | interleukin-23 receptor activity | Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL12RB1 |
GO:0042030 | MF | ATPase inhibitor activity | Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate. |
PLN |
GO:0042043 | MF | neurexin family protein binding | Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. |
SDCBP, CASK, CPE, NLGN4X, NLGN1, SYTL4, SYTL2 |
GO:0042054 | MF | histone methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. |
SUZ12, EZH2, CARM1, PRMT6, PRMT1 |
GO:0042056 | MF | chemoattractant activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. |
PDGFB, FGF2, HMGB1, SAA1, SAA2, CCL3, BMP4, CCL5, SCG2, MIF, HGF, VEGFA, LGALS3, FGF7, HMGB2, CXCL12, VEGFC, ALKBH1 |
GO:0042131 | MF | thiamine phosphate phosphatase activity | Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate. |
ACPP |
GO:0042132 | MF | fructose 1,6-bisphosphate 1-phosphatase activity | Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. |
FBP2, FBP1 |
GO:0042134 | MF | rRNA primary transcript binding | Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript. |
PTRF |
GO:0042162 | MF | telomeric DNA binding | Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
KDM1A, XRCC5, TERF1, HNRNPD, ACD, SMG1, UPF3A, PIF1, OBFC1, UPF2, POT1, SMG5 |
GO:0042163 | MF | interleukin-12 beta subunit binding | Interacting selectively and non-covalently with the beta subunit of interleukin-12. |
IL12A |
GO:0042165 | MF | neurotransmitter binding | Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
NIPSNAP1 |
GO:0042166 | MF | acetylcholine binding | Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. |
CHRNB1, CHRM3, CHRNA5, CHRNA7 |
GO:0042169 | MF | SH2 domain binding | Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. |
SH3PXD2B, SYNGR3, JAK2, IRS1, NUP62, RACK1, PTK2, ARHGAP5, SQSTM1, DAG1, AFAP1L2, SHCBP1, LILRB1, DLC1, TRPV4, PAG1, NLK |
GO:0042171 | MF | lysophosphatidic acid acyltransferase activity | Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. |
ABHD5 |
GO:0042277 | MF | peptide binding | Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds. |
TPP1, GPR37, ANG, RPLP0, MME, CLTA, FURIN, IDE, PPIB, CALR, TPP2, AVPR2, OXTR, GNRHR, CSNK1D, THOP1, PGGT1B, NPEPPS, PPIA, TUBB3, ERAP2, AOPEP, TMEM158, PCSK5, NLN, ERAP1, LNPEP, LOC440434 |
GO:0042281 | MF | dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity | Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. |
ALG8, ALG6 |
GO:0042282 | MF | hydroxymethylglutaryl-CoA reductase activity | Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH. |
HMGCR |
GO:0042285 | MF | xylosyltransferase activity | Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
LARGE |
GO:0042287 | MF | MHC protein binding | Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
MARCH1, CLEC7A |
GO:0042288 | MF | MHC class I protein binding | Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
TUBB, HLA-E, BCAP31, VCP, TUBB4B, LILRB1, CD244, PILRB, PILRA |
GO:0042289 | MF | MHC class II protein binding | Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. |
CD4, CD74, LAG3, KRT17, MARCH8 |
GO:0042296 | MF | ISG15 transferase activity | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
UBE2E1, UBE2E2 |
GO:0042301 | MF | phosphate ion binding | Interacting selectively and non-covalently with phosphate. |
PNP, MTHFD2, ADSS, G6PC, RELA, ADSSL1 |
GO:0042328 | MF | heparan sulfate N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate. |
EXT1, EXT2 |
GO:0042379 | MF | chemokine receptor binding | Interacting selectively and non-covalently with any chemokine receptor. |
CCL5, CXCL12 |
GO:0042392 | MF | sphingosine-1-phosphate phosphatase activity | Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. |
PLPP1, PLPP3, SGPP2 |
GO:0042393 | MF | histone binding | Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. |
APBB1, CHD2, SMARCA5, JAK2, TBL1X, RNF8, TNKS, PRKCB, PTMA, NPM1, CTSL, CD1D, RAG1, H2AFX, RCC1, CKS2, DEK, SNCA, ANP32A, ATRX, MCM2, SMARCA2, CKS1B, HIST1H4A, HIST1H3D, H3F3A, SET, RBBP4, CHAF1B, SART3, NCAPD2, ZMYND11, PKN1, SPTY2D1, ATAD2, SUPT6H, HJURP, CTCFL, ANP32B, L3MBTL2, TONSL, PRMT6, IPO9, UHRF2, PHF12, RSF1, UHRF1, PYGO2, ANP32E, TBL1XR1, CHD8, BRD7, ASF1B, NAP1L2, ASF1A, NOC2L, L3MBTL1 |
GO:0042497 | MF | triacyl lipopeptide binding | Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups. |
TLR2 |
GO:0042500 | MF | aspartic endopeptidase activity, intramembrane cleaving | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. |
SPPL3, SPPL2A, HM13 |
GO:0042562 | MF | hormone binding | Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. |
NPR3, NPR2, CALR, MTNR1A, AMHR2 |
GO:0042577 | MF | lipid phosphatase activity | Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. |
PLPP1, PLPP3, PLPPR4, PLPPR2, INPP5K |
GO:0042578 | MF | phosphoric ester hydrolase activity | Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. |
PGAP1 |
GO:0042602 | MF | riboflavin reductase (NADPH) activity | Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+. |
BLVRB |
GO:0042605 | MF | peptide antigen binding | Interacting selectively and non-covalently with an antigen peptide. |
HLA-B, HLA-DRA, HLA-DQA1, HLA-DQB1, HLA-E, HLA-DPA1, HLA-A, HLA-F, HLA-DRB3, SLC7A9, SLC7A5, DHCR24, HLA-DRB5, CD209, SLC7A8 |
GO:0042608 | MF | T cell receptor binding | Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells. |
FYN, DOCK2 |
GO:0042609 | MF | CD4 receptor binding | Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages. |
PLSCR1, FYN, PLSCR4 |
GO:0042610 | MF | CD8 receptor binding | Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. |
FYN |
GO:0042623 | MF | ATPase activity, coupled | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane. |
VPS4B, HSPA1A, HSPA1B, HSPA6, NSF, CCT8, MYO1E |
GO:0042624 | MF | ATPase activity, uncoupled | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction. |
ATP6V1F |
GO:0042625 | MF | ATPase coupled ion transmembrane transporter activity | Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. |
ATP6V0E1, ATP6V1F |
GO:0042626 | MF | ATPase activity, coupled to transmembrane movement of substances | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane. |
ABCD4, ABCA8, ABCA1, ABCD3, ABCC1, ABCA6, ABCA5, ABCG8, ABCB10, ATP6V1D |
GO:0042658 | MF | MHC class II protein binding, via antigen binding groove | Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules. |
CD74 |
GO:0042731 | MF | PH domain binding | Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. |
EPHA4, INPP5A |
GO:0042799 | MF | histone methyltransferase activity (H4-K20 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein. |
WHSC1, KMT5B, KMT5C, KMT5A |