Search Geneontologies

Geneontologies

GO ID Ontology GO Term Term Definition Proteins

GO:0034186

MF

apolipoprotein A-I binding

Interacting selectively and non-covalently with apolipoprotein A-I.

ABCA1, SCARB1

GO:0034188

MF

apolipoprotein A-I receptor activity

Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

ABCA1

GO:0034189

MF

very-low-density lipoprotein particle binding

Interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.

VLDLR, PCSK9

GO:0034190

MF

apolipoprotein receptor binding

Interacting selectively and non-covalently with an apolipoprotein receptor.

APOA1, APOA2, PCSK9

GO:0034191

MF

apolipoprotein A-I receptor binding

Interacting selectively and non-covalently with an apolipoprotein A-I receptor.

APOA1, NR1H2, CDC42

GO:0034212

MF

peptide N-acetyltransferase activity

Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.

EP300, CREBBP

GO:0034235

MF

GPI anchor binding

Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes.

PIGK, PIGU

GO:0034236

MF

protein kinase A catalytic subunit binding

Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.

PRKAR1A, PRKAR2A, EZR, PRKAR2B, CSK, SOX9, GSK3B, PKIA, RYR2

GO:0034237

MF

protein kinase A regulatory subunit binding

Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.

EZR, PRKACA, AKAP6, AKAP1, RYR2, ACBD3, AKAP7, ARFGEF2

GO:0034353

MF

RNA pyrophosphohydrolase activity

Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end.

DXO

GO:0034417

MF

bisphosphoglycerate 3-phosphatase activity

Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate.

MINPP1

GO:0034431

MF

bis(5'-adenosyl)-hexaphosphatase activity

Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate.

NUDT3, NUDT10, NUDT11

GO:0034432

MF

bis(5'-adenosyl)-pentaphosphatase activity

Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate.

NUDT3, NUDT10, NUDT11

GO:0034437

MF

glycoprotein transporter activity

Enables the directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells.

VLDLR

GO:0034450

MF

ubiquitin-ubiquitin ligase activity

Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

UBR5, UBE4B, RBX1, PPIL2, PELI1, PELI2, AMFR, PRPF19, STUB1

GO:0034452

MF

dynactin binding

Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity.

HTT, BICD1, SNX6, SNX5

GO:0034458

MF

3'-5' RNA helicase activity

Catalysis of the unwinding of an RNA helix in the direction 3' to 5'.

SUPV3L1

GO:0034485

MF

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate.

INPP5D, INPP5K

GO:0034511

MF

U3 snoRNA binding

Interacting selectively and non-covalently with U3 small nucleolar RNA.

SNU13, TSR1, ISG20

GO:0034512

MF

box C/D snoRNA binding

Interacting selectively and non-covalently with box C/D small nucleolar RNA.

SNU13

GO:0034513

MF

box H/ACA snoRNA binding

Interacting selectively and non-covalently with box H/ACA small nucleolar RNA.

DKC1, NOP10, GAR1

GO:0034584

MF

piRNA binding

Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

PIWIL4

GO:0034590

MF

L-hydroxyproline transmembrane transporter activity

Enables the transfer of L-hydroxyproline from one side of a membrane to the other.

SLC1A4

GO:0034594

MF

phosphatidylinositol trisphosphate phosphatase activity

Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate.

INPP5K

GO:0034595

MF

phosphatidylinositol phosphate 5-phosphatase activity

Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate.

SYNJ1, INPP5K

GO:0034596

MF

phosphatidylinositol phosphate 4-phosphatase activity

Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate.

SYNJ2, SYNJ1

GO:0034597

MF

phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity

Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

INPP4B, INPP4A

GO:0034602

MF

oxoglutarate dehydrogenase (NAD+) activity

Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH.

OGDH

GO:0034604

MF

pyruvate dehydrogenase (NAD+) activity

Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH.

PDHA1, DLD, DLAT, PDHB

GO:0034617

MF

tetrahydrobiopterin binding

Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions.

TH, NOS3

GO:0034618

MF

arginine binding

Interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid.

NOS3, RARS

GO:0034632

MF

retinol transporter activity

Enables the directed movement of retinol into, out of or within a cell, or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.

RBP4

GO:0034647

MF

histone demethylase activity (H3-trimethyl-K4 specific)

Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein.

KDM5B

GO:0034648

MF

histone demethylase activity (H3-dimethyl-K4 specific)

Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein.

KDM1A, KDM5B

GO:0034711

MF

inhibin binding

Interacting selectively and non-covalently with an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers.

INHA, INHBA, ACVR2A, ACVR1B

GO:0034713

MF

type I transforming growth factor beta receptor binding

Interacting selectively and non-covalently with a type I transforming growth factor beta receptor.

SMAD7, SMAD6, TGFB1, TGFBR2, SMAD2

GO:0034714

MF

type III transforming growth factor beta receptor binding

Interacting selectively and non-covalently with a type III transforming growth factor beta receptor.

TGFB1, TGFB2

GO:0034722

MF

gamma-glutamyl-peptidase activity

Catalysis of the cleavage of a gamma-linked glutamate bond.

GGH

GO:0034736

MF

cholesterol O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA.

SOAT1

GO:0034875

MF

caffeine oxidase activity

Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O.

CYP3A4, CYP2C9

GO:0034979

MF

NAD-dependent protein deacetylase activity

Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.

SIRT2

GO:0034986

MF

iron chaperone activity

Assists in the delivery of iron ions to target proteins or compartments.

FXN

GO:0034987

MF

immunoglobulin receptor binding

Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.

IGLL5, FGR, CLEC4D

GO:0034988

MF

Fc-gamma receptor I complex binding

Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.

FGR, FLNA

GO:0035004

MF

phosphatidylinositol 3-kinase activity

Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring.

PIK3CD, PIK3C2A, PIK3CA, PIK3CB, PIK3CG

GO:0035005

MF

1-phosphatidylinositol-4-phosphate 3-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).

PIK3CD, PIK3C2A, PIK3CA, PIK3CB, PIK3CG

GO:0035014

MF

phosphatidylinositol 3-kinase regulator activity

Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.

KLF4, PIK3R1

GO:0035033

MF

histone deacetylase regulator activity

Modulates the activity of histone deacetylase.

MAPK8

GO:0035034

MF

histone acetyltransferase regulator activity

Modulates the activity of histone acetyltransferase.

PYGO2, EID1

GO:0035035

MF

histone acetyltransferase binding

Interacting selectively and non-covalently with the enzyme histone acetyltransferase.

ZBTB7A, TP53, GLI3, PCNA, ETS1, CREB1, CEBPB, EGR1, MEF2A, MTF1, HIF1A, SIRT2, NR4A3, EPAS1, CITED2, FOXP3, EID1

GO:0035064

MF

methylated histone binding

Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.

CHD1, CBX7, NCAPD3, CBX5, ATRX, MSH6, FMR1, SUZ12, RBBP5, ZMYND11, GLYR1, PHF19, KDM7A, NCAPG2, L3MBTL2, SGF29, UHRF1, MPHOSPH8, CHD8, ING3, LRWD1, CDYL, L3MBTL1, MTF2, LOXL2, SPIN1

GO:0035091

MF

phosphatidylinositol binding

Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

ESYT2, HIP1, PIK3C2A, ARHGAP33, TULP3, SNX4, SNX16, PITPNA, FCHO2, MYO1E, PLD1, MTM1, SNX1, ITPR2, ITPR3, ITPR1, CCDC88A, HS1BP3, PXK, TRPV1, SNX29, SNX33, MITD1, ZCCHC14, SGK3, SH3YL1, PHF12, PASK, ZCCHC2, PLEKHA2, TULP4, SNX15, WDR35, PITPNC1, SNX12, SNX6, NISCH, SNX9, SNX5

GO:0035173

MF

histone kinase activity

Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.

CDK1, CCNB1, CDK2, BAZ1B

GO:0035174

MF

histone serine kinase activity

Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.

AURKA, PRKAA2, AURKB

GO:0035175

MF

histone kinase activity (H3-S10 specific)

Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3.

RPS6KA5, VRK1

GO:0035197

MF

siRNA binding

Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.

FMR1, AGO2, DICER1

GO:0035198

MF

miRNA binding

Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.

HNRNPA2B1, POU5F1, MEF2C, FMR1, PNPT1, RBM4, LIN28A, AGO4, AGO2

GO:0035226

MF

glutamate-cysteine ligase catalytic subunit binding

Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase.

GCLM

GO:0035240

MF

dopamine binding

Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine.

TH, DRD2

GO:0035241

MF

protein-arginine omega-N monomethyltransferase activity

Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue.

PRMT6

GO:0035242

MF

protein-arginine omega-N asymmetric methyltransferase activity

Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues.

PRMT3, CARM1, PRMT6, PRMT1

GO:0035250

MF

UDP-galactosyltransferase activity

Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule.

B4GALT1

GO:0035252

MF

UDP-xylosyltransferase activity

Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule.

LARGE, XXYLT1

GO:0035255

MF

ionotropic glutamate receptor binding

Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.

FLOT1, DRD2, CANX, FUS, DLG4, GNAS, DLG1, GNAS, NETO2

GO:0035256

MF

G-protein coupled glutamate receptor binding

Interacting selectively and non-covalently with a G-protein coupled glutamate receptor (a metabotropic glutamate receptor).

HOMER1, HOMER3

GO:0035257

MF

nuclear hormone receptor binding

Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.

ACTN4, NCOR1, TACC2, CTNNB1, BUD31, NRIP1, EP300, NCOA2, NCOA1, CRY1, HIF1A, SMARCD3, NCOA7, TCF7L2, NCOA3

GO:0035258

MF

steroid hormone receptor binding

Interacting selectively and non-covalently with a steroid hormone receptor.

NR0B1

GO:0035259

MF

glucocorticoid receptor binding

Interacting selectively and non-covalently with a glucocorticoid receptor.

ETS2, CEBPB, STAT3, NR4A2, NRIP1, STAT5B, FKBP4, YWHAH, NR4A3

GO:0035276

MF

ethanol binding

Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH.

ADH7

GO:0035312

MF

5'-3' exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.

DCLRE1C, EXO1

GO:0035325

MF

Toll-like receptor binding

Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.

TLR2, TOLLIP

GO:0035326

MF

enhancer binding

Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.

TCF3, ARNT, AHR, SOX9, SMAD3, HNRNPU, SMAD2, TCF12

GO:0035368

MF

selenocysteine insertion sequence binding

Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation.

SECISBP2L, SECISBP2

GO:0035373

MF

chondroitin sulfate proteoglycan binding

Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.

PTPRF, SEMA5A

GO:0035374

MF

chondroitin sulfate binding

Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).

DPYSL3

GO:0035375

MF

zymogen binding

Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.

DMBT1

GO:0035401

MF

histone kinase activity (H3-Y41 specific)

The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.

JAK2

GO:0035402

MF

histone kinase activity (H3-T11 specific)

Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3.

CHEK1, PKN1

GO:0035403

MF

histone kinase activity (H3-T6 specific)

Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3.

PRKCB, PRKCA

GO:0035410

MF

dihydrotestosterone 17-beta-dehydrogenase activity

Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH.

AKR1C3

GO:0035472

MF

choriogonadotropin hormone receptor activity

Combining with the choriogonadotropin hormone to initiate a change in cell activity.

LHCGR

GO:0035473

MF

lipase binding

Interacting selectively and non-covalently with any lipase.

APOB, LRPAP1, PLIN5, APOA5, FAF2

GO:0035497

MF

cAMP response element binding

Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.

JUN, CREB1, ATF6, HMGA2, CREB3L1, TCF12

GO:0035500

MF

MH2 domain binding

Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.

HMGA2

GO:0035501

MF

MH1 domain binding

Interacting selectively and non-covalently with the MH1 (MAD homology 1) domain of a protein. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors.

HMGA2

GO:0035515

MF

oxidative RNA demethylase activity

Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.

ALKBH5, FTO

GO:0035516

MF

oxidative DNA demethylase activity

Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.

FTO

GO:0035529

MF

NADH pyrophosphatase activity

Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+.

ENPP3, ENPP1

GO:0035539

MF

8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.

NUDT1, NUDT15

GO:0035575

MF

histone demethylase activity (H4-K20 specific)

Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein.

KDM7A

GO:0035591

MF

signaling adaptor activity

The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.

RACK1, LDLRAP1, HOMER1, AFAP1L2, SH2B1, SH2B3

GO:0035598

MF

N6-threonylcarbomyladenosine methylthiotransferase activity

Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).

CDKAL1

GO:0035605

MF

peptidyl-cysteine S-nitrosylase activity

Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein.

GAPDH

GO:0035612

MF

AP-2 adaptor complex binding

Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).

AAK1, LDLRAP1, TBC1D5

GO:0035613

MF

RNA stem-loop binding

Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.

DDX3X, EPRS, FMR1, CPEB3, DAZAP1

GO:0035614

MF

snRNA stem-loop binding

Interacting selectively and non-covalently with a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.

SNRPA

GO:0035615

MF

clathrin adaptor activity

The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way.

AP2A2, AP2S1, AP2B1, DAB2, PICALM, LDLRAP1, AP2M1

GO:0035642

MF

histone methyltransferase activity (H3-R17 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3.

CARM1

GO:0035650

MF

AP-1 adaptor complex binding

Interacting selectively and non-covalently with the AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).

RAB32

GO:0035651

MF

AP-3 adaptor complex binding

Interacting selectively and non-covalently with the AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).

RAB32

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