| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0001161 | MF | intronic transcription regulatory region sequence-specific DNA binding | Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within. |
BCL6, NKX2-1 |
GO:0001162 | MF | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within. |
HSF1, NCOA2, ZNF350, SMYD3 |
GO:0001164 | MF | RNA polymerase I CORE element sequence-specific DNA binding | Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE. |
UBTF, SMARCA4, TAF1C, TAF1B, RRN3 |
GO:0001165 | MF | RNA polymerase I upstream control element sequence-specific DNA binding | Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I. |
UBTF |
GO:0001179 | MF | RNA polymerase I transcription factor binding | Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I. |
POLR1E |
GO:0001187 | MF | transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting | Interacting selectively and non-covalently with the CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery and also binding to an RNA polymerase I (RNAP I) transcription factor to recruit it to the transcription machinery complex in order to modulate transcription by RNA polymerase I. |
TAF1B |
GO:0001190 | MF | transcriptional activator activity, RNA polymerase II transcription factor binding | Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
WWP2, KLF4, JUN, CREB1, LMO2, NOTCH1, PPARA, NFE2L1, NR1H4 |
GO:0001191 | MF | transcriptional repressor activity, RNA polymerase II transcription factor binding | Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
AHRR, BHLHE40, MINA, CREBBP, SPEN |
GO:0001205 | MF | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
BACH1, NFATC1, HOXB5, HMGA1, NFKB1, SUB1, RELA, REL, MEF2C, TARDBP, NFE2L1 |
GO:0001206 | MF | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
BACH1, PAX4, HIVEP1, ZBTB16, BACH2 |
GO:0001221 | MF | transcription cofactor binding | Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. |
KLF4, FOXO3 |
GO:0001222 | MF | transcription corepressor binding | Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. |
NR1D1, RORA, HDGF, PHF12, CDC5L |
GO:0001223 | MF | transcription coactivator binding | Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
CCNT2, RORA, TFAM, PPARA, FOXO1, NR4A3 |
GO:0001225 | MF | RNA polymerase II transcription coactivator binding | Interacting selectively and non-covalently with an RNA polymerase II transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II. |
NFATC1 |
GO:0001227 | MF | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
FOXO3, ZEB2, MITF, NFKB1, ZEB1, BCL6, SATB1, POU5F1, PPARD, ARID5B, NFATC4, ZNF280D, ZNF280B, AEBP1, HES6, PURB, MNT, ZNF350, ZBTB4, MLX |
GO:0001228 | MF | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
MAFG, FOXO3, RAD21, MAF, TP53, ATF1, ATF3, LMO2, RXRB, STAT3, ETV5, GATA4, RUNX1, GABPA, DLX2, EP300, FOXC1, HIF1A, CSRNP3, GATA6, CSRNP1, ARID3A, CSRNP2, SOX17, TRPS1, ELF5, MAFF, PLAGL1, MAFB |
GO:0001515 | MF | opioid peptide activity | Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect. |
PENK |
GO:0001517 | MF | N-acetylglucosamine 6-O-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. |
CHST3, CHST4, CHST5, CHST6, CHST7, CHST2 |
GO:0001530 | MF | lipopolysaccharide binding | Interacting selectively and non-covalently with lipopolysaccharide. |
TLR4, TLR2, CD14, HMGB1, HSPD1, PTAFR, PSMB4, CD6, SCARB1, SPON2 |
GO:0001537 | MF | N-acetylgalactosamine 4-O-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate. |
CHST11 |
GO:0001540 | MF | beta-amyloid binding | Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. |
GSAP, APBB1, ITM2A, CLSTN1, APBB3, CST3, APOA1, APOE, CD74, IDE, CHRNA7, TGFB2, APBA1, MAPK8IP2, LDLRAP1, SORL1, APBB2, GPRASP2, TM2D1, ITM2B |
GO:0001567 | MF | cholesterol 25-hydroxylase activity | Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O. |
CH25H, CYP2C9 |
GO:0001587 | MF | Gq/11-coupled serotonin receptor activity | Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. |
HTR2C |
GO:0001591 | MF | dopamine neurotransmitter receptor activity, coupled via Gi/Go | Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. |
DRD2 |
GO:0001596 | MF | angiotensin type I receptor activity | An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. |
AGTR1 |
GO:0001601 | MF | peptide YY receptor activity | Combining with gut peptide YY to initiate a change in cell activity. |
NPY1R, NPY2R, NPY5R |
GO:0001602 | MF | pancreatic polypeptide receptor activity | Combining with pancreatic polypeptide PP to initiate a change in cell activity. |
NPY1R, NPY5R |
GO:0001609 | MF | G-protein coupled adenosine receptor activity | Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
ADORA2B, ADORA1 |
GO:0001614 | MF | purinergic nucleotide receptor activity | Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
P2RX4 |
GO:0001616 | MF | growth hormone secretagogue receptor activity | Combining with ghrelin to initiate a change in cell activity. |
GHSR |
GO:0001618 | MF | virus receptor activity | Combining with a virus component and mediating entry of the virus into the cell. |
NPC1, SIVA1, CLDN1, LDLR, CD4, GYPA, TFRC, ITGB3, ICAM1, ITGB1, ITGAV, CD55, ITGA5, RPSA, HSPA1A, HSPA1B, LAMP1, NCAM1, IDE, PVR, CD46, ITGA2, CR1, ITGB5, MRC1, DPP4, SERPINB3, EFNB2, CXCR4, CXADR, TYRO3, SLC20A2, HYAL2, DAG1, SELPLG, NECTIN1, SLC1A5, SCARB1, CD209, F11R |
GO:0001626 | MF | nociceptin receptor activity | Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. |
OPRL1 |
GO:0001635 | MF | calcitonin gene-related peptide receptor activity | Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. |
CRCP |
GO:0001641 | MF | group II metabotropic glutamate receptor activity | A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. |
GRM3 |
GO:0001642 | MF | group III metabotropic glutamate receptor activity | A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. |
GRM8, GRM6 |
GO:0001664 | MF | G-protein coupled receptor binding | Interacting selectively and non-covalently with a G-protein coupled receptor. |
PARK2, POMC, GNAI2, FYN, PSAP, GNAI3, SAA1, HSPA1A, HSPA1B, ITGB4, FLNA, S1PR1, ADORA1, DNAJA1, GNAI1, NPB, PACRG, GPRC5B, GHRL, APLN, STUB1, USP20 |
GO:0001665 | MF | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. |
ST6GALNAC5, ST6GALNAC4, ST6GALNAC2 |
GO:0001671 | MF | ATPase activator activity | Binds to and increases the ATP hydrolysis activity of an ATPase. |
DNAJB6, ATP1B1, DNAJB1, ATP1B3, AHSA2, DNAJC10, DNAJC1, DNAJC7 |
GO:0001735 | MF | prenylcysteine oxidase activity | Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2. |
PCYOX1 |
GO:0001758 | MF | retinal dehydrogenase activity | Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. |
ALDH1A2, ALDH1A1, AKR1C3, ALDH1A3, ALDH8A1 |
GO:0001784 | MF | phosphotyrosine binding | Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. |
FGR, MAPK3, MAPK1, GRB2, CBLB, LDLRAP1, SAMSN1 |
GO:0001785 | MF | prostaglandin J receptor activity | Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. |
PTGDR |
GO:0001786 | MF | phosphatidylserine binding | Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. |
THBS1, HMGB1, GAP43, SYT1, PLCD1, MFGE8, FCHO2, GAS6, SCARB1, OSBPL10, OSBPL8, SYTL2, MARK1 |
GO:0001846 | MF | opsonin binding | Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. |
ITGAV |
GO:0001847 | MF | opsonin receptor activity | Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
CD14 |
GO:0001848 | MF | complement binding | Interacting selectively and non-covalently with any component or product of the complement cascade. |
CFB, C8G, C4A, C4B |
GO:0001849 | MF | complement component C1q binding | Interacting selectively and non-covalently with the C1q component of the classical complement cascade. |
CRP, APCS, C4A, PTX3, CALR, C1QBP, CD93 |
GO:0001850 | MF | complement component C3a binding | Interacting selectively and non-covalently with the C3a product of the complement cascade. |
PHB |
GO:0001851 | MF | complement component C3b binding | Interacting selectively and non-covalently with the C3b product of the complement cascade. |
CR1, PHB |
GO:0001855 | MF | complement component C4b binding | Interacting selectively and non-covalently with the C4b product of the classical complement cascade. |
MASP2, CR1 |
GO:0001856 | MF | complement component C5a binding | Interacting selectively and non-covalently with the C5a product of the complement cascade. |
C5AR1 |
GO:0001861 | MF | complement component C4b receptor activity | Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
CR1 |
GO:0001872 | MF | (1->3)-beta-D-glucan binding | Interacting selectively and non-covalently with (1->3)-beta-D-glucans. |
PTX3 |
GO:0001875 | MF | lipopolysaccharide receptor activity | Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
TLR4, TLR2, PTAFR, SCARB1 |
GO:0001882 | MF | nucleoside binding | Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. |
ACTN4, PNP, POLA1 |
GO:0001883 | MF | purine nucleoside binding | Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. |
ADA, ADORA1 |
GO:0001948 | MF | glycoprotein binding | Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. |
SDCBP, EGFR, PLAT, SERPINA1, LDLR, TGFB1, CD4, APOH, TFRC, VWF, ITGB2, FYN, HSP90AA1, THBS1, HSP90AB1, VIM, LGALS1, HSPA5, ITGAM, IGF2R, IDE, SDC1, RASA1, FLNA, AZGP1, ITGA3, CALR, CANX, BMPR1A, CSNK1D, B2M, VLDLR, CNTN1, OS9, SHB, EDEM1, FBXO17, BBC3, TFR2 |
GO:0001965 | MF | G-protein alpha-subunit binding | Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. |
RGS10, IGF2R, F2R, RGS2, HTR2B, RGS4, F2RL1, GPSM2, NUCB1 |
GO:0001968 | MF | fibronectin binding | Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. |
ITGB3, ITGB1, ITGAV, CTSL, THBS1, VEGFA, IGFBP3, FBLN1, IGFBP5, CTSS, ITGA3, CTGF, SDC4, CTSK, HSD17B12, CCDC80, PLEKHA2 |
GO:0001972 | MF | retinoic acid binding | Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. |
CYP26A1, SERPINA5, IGF2R, NR2F2, CYP26B1 |
GO:0002020 | MF | protease binding | Interacting selectively and non-covalently with any protease or peptidase. |
CHL1, CFLAR, FLOT1, BCL10, SERPINC1, SERPINA1, A2M, TIMP1, CST3, CSTA, LDLR, INS, TNF, FN1, CSTB, VWF, TP53, ITGB3, SERPINE1, SERPINA5, ITGB1, ITGAV, ANXA2, CST2, FURIN, UBC, BCL2, KIT, CD28, HSPD1, SELL, IL1R1, TIMP2, TNFAIP3, ITGA3, DPP4, SERPINB3, SRI, TIMP3, SERPINB4, COMP, SERPINB9, INSL3, BRCA2, POLG, CRADD, FADD, OS9, ADRM1, NFRKB, CCBE1, ADAMTSL4, LONP2, TTN, RFFL, PANX1, PEO1, PINK1, SERPINB13, PYCARD |
GO:0002039 | MF | p53 binding | Interacting selectively and non-covalently with one of the p53 family of proteins. |
TRIAP1, NUAK1, KDM1A, BRD4, TP53, HSPD1, EEF2, MUC1, HTT, GSK3B, SMARCA4, PTTG1IP, BLM, PSME3, CDK5, MDM2, EP300, TP53BP2, ANKRD1, STK11, ZNF385B, ZMAT1, RFWD3, BANP, SETD7, RFFL, CREBBP, EHMT2, TP53RK, TEP1, DUSP26, BCL2L12, CHD8, BRD7, KMT5A, CDKN2AIP |
GO:0002055 | MF | adenine binding | Interacting selectively and non-covalently with adenine, a purine base. |
APRT |
GO:0002060 | MF | purine nucleobase binding | Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton. |
PNP |
GO:0002083 | MF | 4-hydroxybenzoate decaprenyltransferase activity | Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate. |
COQ2 |
GO:0002113 | MF | interleukin-33 binding | Interacting selectively and non-covalently with interleukin-33. |
IL1RL1 |
GO:0002114 | MF | interleukin-33 receptor activity | Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL1RL1, IL1RAP |
GO:0002134 | MF | UTP binding | Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate. |
HSP90AA1, HSP90AB1, MTPAP |
GO:0002135 | MF | CTP binding | Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate. |
HSP90AA1, HSP90AB1 |
GO:0002151 | MF | G-quadruplex RNA binding | Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad. |
FXR1, AFF2, FMR1, DHX36, LIN28A |
GO:0002153 | MF | steroid receptor RNA activator RNA binding | Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding. |
THRA |
GO:0002161 | MF | aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
LARS2, DTD2 |
GO:0002162 | MF | dystroglycan binding | Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal). |
MAP2, DMD, DAG1, AGR3 |
GO:0002950 | MF | ceramide phosphoethanolamine synthase activity | Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine. |
SGMS1 |
GO:0003674 | MF | molecular_function | Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. |
TMEM129, TMEM120B, ILVBL, SBNO1, MATN2, DSCR3, KHNYN, CTDSPL, DENR, C21orf2, ORC5, ZNF862, NUPR1, HIST1H2BK, ARL6IP5, ZFAND5, SEC24D, HAUS5, AP2A2, NXPH3, SFT2D2, LRG1, A1BG, PRB1, COL5A2, TPM3, CLTA, NUDT7, HIST1H2AG, ZNF688, TPR, TMEM11, HIST1H2AD, MST1, G0S2, PBLD, TM4SF1, MPV17, IFI27, NPTX2, SLC6A8, NES, MEOX1, LRBA, PTTG1IP, CRISP3, TMEM50B, HIST1H2BD, ROMO1, RAB4B, HIST1H2BC, SNRPN, DLK1, MRPS10, SERF2, ZXDB, ZNF200, REEP5, LMNB2, ICA1, DMWD, ELP6, MN1, IFRD2, NPRL3, MLLT11, SCGB2A2, GPM6B, MAMLD1, FHL1, DGCR6, TRIM14, FAM53B, POLA2, TMEM187, LPIN1, NOMO1, ADIRF, FAM189A2, ZNF77, CSRP2, CARTPT, TMEM132A, QRICH1, FILIP1L, ARID4B, LRRC23, TMEM35, ACSM3, ANKRD39, BOLA3, TMEM128, SLC25A30, EYS, KIAA1217, IDNK, ACBD5, RSPH4A, NDUFAF5, ANKRD45, STRIP1, CDKAL1, ANKRD40, HIST2H2AA3, ZFAND6, ADNP2, TTC27, INO80C, BLOC1S3, WDR74, POTEE, SBSN, C5orf46, TMEM107, TMEM108, HSDL2, TMEM91, FAM65A, LHFPL2, PTCHD4, H2AFV, KNDC1, BTN2A1, HAUS6, KDELC2, CENPV, THNSL2, TDRP, CARKD, SLC35F2, ZC3H3, THNSL1, BEST3, TMEM256, TMEM132C, ZADH2, OXR1, TMEM57, ZNF655, ABTB2, FAM184A, PDDC1, SLC43A3, GSTCD, ABHD11, BPIFB1, SCFD2, CHAC2, CHCHD10, SUSD6, DCUN1D4, LPGAT1, N4BP2L2, HIST1H2AC, TMEM106A, KIAA1191, PTER, DOCK10, HAUS1, DTD2, ZNF486, CYYR1, L3MBTL3, ZNF75A, ZFP3, PTCHD1, KLHL5, CSRNP1, MYADM, CDCA3, PKP2, TMEM47, TMEM121, H2AFJ, HGH1, TUBB6, C9orf16, TIMM21, TMEM106C, C1QTNF3, TMEM120A, FSD1L, RTFDC1, TRIM34, NUF2, ASPSCR1, UACA, GPR63, FAM129A, UBXN6, TM6SF1, TRIM6, ZC3H12C, KLHL4, C20orf27, C6orf62, SPATC1L, CYSTM1, ADAMTS10, TMEM245, CRISPLD1, GHITM, C11orf1, FAM96A, HAUS4, SEC61A2, C17orf75, FANCE, POPDC2, POPDC3, EML4, WFDC1, TMEM8A, EPB41L4A, CD248, MRPL47, IFT46, MXRA5, SMCO4, TM7SF3, BRWD1, TMEM106B, SDAD1, HAUS2, TMEM51, C1orf123, DONSON, MIS18A, GTSE1, FMN2, SEPN1, EMC3, TMEM9, IMPACT, STOML1, HECA, ARPP21, CFDP1, EPHA6, FETUB, TMEFF2, GGA1, C14orf1, CCPG1, NDRG4, NDRG2, TRIM35, DIP2C, KIAA0430, GPSM3, AIM1, AMMECR1, CEP83, RAI2 |
GO:0003676 | MF | nucleic acid binding | Interacting selectively and non-covalently with any nucleic acid. |
ERI2, ENPP3, ZNF862, RNASE1, ZNF853, RNASE2, SON, ENPP1, RNASE4, USP6, POLR2I, ZXDB, ENPP2, GTF2H2, KRBOX4, THOC7, ZNF585A, ZNF880, CBLL1, ZNF720, JAZF1, CHD1L, REXO1, METTL4, ZNF843, SREK1IP1, DBF4B, OSR1, ZCCHC10, ENOX1, HELQ, N6AMT2, SNRNP27, ZCCHC14, DPF3, R3HDM4, ZNF503, CHAMP1, ZFP91, TTC14, RBM15, SPEN, TREX2, SCAPER, ZCCHC2, PEG3, EHD4, SMARCAD1, RAVER2, PRDM6, METTL5, GPATCH2, RBAK, EHD3, ZNRD1, ARPP21, DBF4, TBK1, PNMA3, CIZ1, EXOG, POLR3K, REXO2, R3HCC1, SAMHD1, N6AMT1 |
GO:0003677 | MF | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
ZNF320, EME2, ZNF233, ZNF785, STRA13, AHRR, CENPBD1, ZNF879, NACA, ARNTL, NR5A2, ZNF593, DDX3X, NFIB, ARID1A, CHD1, CHD2, PDCD5, IRF6, TFEC, HNRNPDL, BTAF1, ZNF646, ZBTB5, POLR1C, PLSCR1, SMAD9, SOX12, FOXP2, ZBTB24, PAX4, RAD51C, FOXO3, ZNF207, SOX15, SMARCA5, ZEB2, NUPR1, HBP1, CCNT1, REV3L, HIST1H2BK, PQBP1, ZNF623, DNAJB6, H2AFY, TADA2A, SUPT3H, BANF1, WDHD1, TCEA3, RAD51D, ZNF189, KLF7, ZFAND5, TOX4, TOX, FSBP, ZFPL1, LUC7L3, KIF4A, ZBTB7A, POLR1A, YEATS4, ZMYM6, AIFM1, MBD3, SERPINA3, MYC, ALB, ANG, MYCN, TP53, APP, JUN, RB1, PGR, ENO1, NPM1, PARP1, POLA1, HIST1H2AG, ZNF688, AR, IRF1, TOP1, TOP2A, VDR, ESRRA, PC, XRCC5, GTF2F2, ETS1, ETS2, ZNF44, ZNF250, HIVEP1, TCF4, RAG1, TCF3, H2AFX, ZNF823, ZFX, ZNF12, ZNF14, ZNF17, ZNF19, ZNF20, ZNF182, ZNF22, ZNF23, ZNF24, ZNF25, ZNF43, HMGA1, JUNB, CEBPB, XBP1, ERCC2, RPL7, EGR1, SON, ATF4, LIG1, POLR2E, HIST1H2AD, BCL3, TNFAIP3, NME2, NR4A1, SP100, POLR2A, MCM3, NFYB, YY1, DNMT1, HMGB2, ZFP36, CALR, POLD1, SMARCA1, MAPK1, KDM5A, EEF1D, POLR2B, HIVEP2, HIST1H2BB, MCM7, GTF2F1, RORA, FUS, DDIT3, DEK, SOX6, ZNF93, AHR, SREBF1, PPARG, BRCA1, FEN1, PBX1, STAT3, RFC3, ETV5, MNDA, TMPO, TMPO, STAT5A, RPS27, MSH2, NR4A2, GATA4, NKX2-1, MKI67, RECQL, ATRX, ZFP36L2, RFX2, RFX5, PRIM2, MCM2, NUP153, MRE11A, MXI1, ASCL1, ZNF83, ZNF84, DNA2, NR0B1, HDGF, POLR2J, AGFG1, STAT2, GTF2A1, ZNF133, ZNF136, ZNF140, RBM5, HMGA2, FOSB, CEBPG, POLR2K, RCAN1, POLG, ATXN1, TERF1, PMS1, NR1H2, MLLT10, FOXG1, POLE2, SOX8, KLF3, PCBP4, FOXL2, HIST1H2BD, ZNF445, HIST1H4A, HIST1H2BC, POLR2L, YBX1, RBM6, GTF2I, NUCB2, SIM1, TMF1, SARNP, FOXO4, HNRNPU, E2F1, SET, DR1, POU5F1, BNC1, NUCB1, CREM, PPARD, CENPC, CEBPZ, ZNF85, RELA, EGR4, ZNF91, ZBTB16, APLP2, GABPA, PAX8, ZNF33A, EGR3, ZFP36L1, KHDRBS1, POLE, PPARA, SOS1, SOS2, SSRP1, ZNF844, ZNF616, EP300, ZNF763, FAAP100, ZNF816, TFCP2, TCF15, TRIM26, ILF2, ILF3, FOXC1, PRDM2, ZBTB17, NR1H3, TRIM28, G3BP1, ORC1, IKZF1, NFATC2, SMAD4, NACA, KLF9, C1D, CBFB, NFYC, VEZF1, POLA2, TFDP1, SIM2, ZMYM3, E2F2, HES1, MXD4, ZNF345, ZNF268, ZNF846, KIF22, CHD4, ARID5B, MTF1, DRAP1, SHPRH, ANKRD1, PUM3, NR0B2, TEAD4, TEAD2, TAF1A, TSN, SMAD2, EZH2, ZNF77, ZNF124, PDCD2, TAF12, CRY1, HLF, NFIL3, HIST2H2BE, ZNF423, ZNF630, ERCC6L, QRICH1, LRRFIP1, ZNF791, CHD9, GON4L, ZNF568, ZNF404, GLYR1, ZFP69, ZBED5, FLYWCH1, SMUG1, ZNF326, CENPW, ZNF789, ZMAT1, ZNF766, ZNF667, ZBTB41, ZNF684, ZNF648, ZNF618, ERCC6L2, SPTY2D1, ZNF776, ZNF57, ZNF518A, ZNF787, HIST2H2AA3, ZFAND6, OTUD7B, ADNP2, ZNF280D, TIGD7, MIS18BP1, ZNF529, NFRKB, CERS6, BNC2, ZNF600, ZNF621, TSHZ1, H2AFV, SSH2, ZNF534, ASXL2, SUPT6H, ZNF765, ZNF771, BEND5, EPM2AIP1, HIST3H2A, ZNF627, ZNF367, SETX, ZNF550, MIER3, DENND4A, HUWE1, ZNF467, PEG10, TADA2B, PBRM1, CASZ1, SPATA24, GPBP1, ZNF677, ZNF573, ZNF280B, NOSTRIN, MGA, BAP18, ZC3H3, SRRM1, SUPV3L1, FANCM, ZNF440, ZBED8, ZNF101, XRN1, ZNF654, ZFP82, APITD1, PHTF2, LCORL, ZNF808, ZNF276, CERS5, ZNF655, ZNF283, ZNF513, ZNF615, KIAA1958, ZNF709, ZNF557, ZNF565, BANP, ZNF610, THAP8, ZNF579, ZNF511, HJURP, ZNF485, ZBTB34, MSANTD4, PAPD5, ZNF248, PHC3, GLIS3, ZNF555, KMT2C, ARID1B, ZFP28, CTCFL, ZNF420, THAP6, ZSCAN18, ZNF596, ZNF507, ZNF675, SSH3, ZNF721, ZNF526, ZNF384, THAP3, GTF3C2, NAT14, RNF141, ZFPM2, ZNF606, BBX, KAT6B, AHCTF1, H1FX, TOPBP1, NR4A3, GTF3A, RAD54L, ESR2, PROX1, KAT6A, TAF15, RAD50, KHSRP, SNAPC3, HIST1H2AC, HIST1H2BH, ZNF566, EME1, ZNF669, ZNF689, ZBTB10, ZNF764, ZNF625, ZNF845, ZBED3, HIC2, ZNF333, ZNF462, LCOR, ZBTB45, ZNF521, DNAJC1, SCYL1, ZNF512B, ZFR, ZNF75A, ZNF578, ZNF641, ZMAT2, ZNF285, ZFP3, TOX2, ZNF317, UHRF2, PPP1R10, ZNF300, CIC, ZNF347, STRBP, ZNF607, ZNF587, SPEN, SETDB2, CDC5L, TEAD3, KLF6, NPAS2, EPAS1, HOPX, TCF25, ZNF559, AIFM2, ZNF2, IER2, H2AFJ, ZNF692, POLR3C, ZNF426, PHF20, TIPIN, REPIN1, NUSAP1, HELZ2, ZNF518B, ZNF436, ZNF407, POLR2J2, POLR1E, ZNF350, ZNF700, THAP2, DNTTIP1, CDT1, BLZF1, PNN, SMARCAD1, TAF1D, ZNF395, ZFAND3, LIN28A, CERS4, SAP30L, SP110, RC3H2, PATZ1, ZNF287, GPBP1L1, ZBTB20, HES4, ZNF160, CHD8, TCF7L1, ZNF334, HMG20A, MYNN, PRDM10, ZNF71, ZNF302, POLE4, ASH1L, SLC2A4RG, TSHZ2, POLE3, CHRAC1, KIF15, PDS5B, ZFP64, FANCI, ZNF358, POLR3B, PARPBP, SPHK1, ABI2, BCLAF1, ZNF226, EHF, ZNF224, ZKSCAN7, HMG20B, MYEF2, PSMC3IP, PPARGC1A, ASH2L, ZMYM2, KDM5B, PARP2, TCF20, HMGXB4, MLX, DDX20, NUFIP1, PUF60, DACH1, ZNF230, MUTYH, RABGEF1, ZMYM5, MCM8, ZFP69B, ZNF112, PURG, ZNF222, ZNF580, GTF3C4, ZHX1, ZNF236, TCFL5, MYT1L, PLAGL1, KMT2B, PHTF1, SCML1, GTF2A1L, TTF2, TRIM33, PA2G4, EXO1, SCML2, PIN4, LZTS1, RNF6, MYRF, KDM2A, HIF3A, POLR1D, POLDIP2, LEMD3, CARHSP1, ZNF337, RABGAP1, ZNF175, MTF2, JRKL, CSDC2, NCOR2, RAD54B, LHFP |
GO:0003678 | MF | DNA helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. |
FSBP, MCM3, MCM5, RECQL, ATRX, MCM2, DNA2, SETX, SUPV3L1, FBXO18, CHD8, RUVBL2, RUVBL1, RAD54B |
GO:0003680 | MF | AT DNA binding | Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA). |
HMGA1, HMGA2, MEF2C, HNRNPD |
GO:0003682 | MF | chromatin binding | Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
APBB1, SUPT5H, MEIS1, NR5A2, HDAC3, TOX3, SMAD6, SNAI2, RAD21, SOX15, KDM1A, NUPR1, CCNT1, CCNT2, BRD4, SIN3B, POLQ, TADA2A, RNF8, URI1, TRIM37, CBX7, ACTL6A, WHSC1, EGFR, FOS, ESR1, TP53, MPO, JUN, PRKCB, CDK1, CENPB, POLA1, GLI2, GLI3, AR, EGR2, TOP1, TOP2A, PCNA, TPR, SKI, SKIL, FOSL2, HMGA1, TAL1, CEBPB, RCC1, ELK1, NFKB1, SFPQ, BRD2, POLD1, HOXD10, POLR2B, GTF2H1, CKS2, MCM5, DEK, SREBF1, NUP62, PPARG, ZEB1, RBMX, PBX2, MLH1, BCL6, NCAPD3, GATA4, CBX5, ATRX, YAP1, SOX9, CENPA, CENPF, MEOX1, LHX2, ASCL1, SMARCA2, STAT5B, MSH6, POLG, PRKAA2, HDAC4, CTBP2, YBX1, CBX1, TFAM, RELB, SATB1, MEF2A, SP3, HHEX, RELA, SSBP1, REL, MEF2C, GABPA, RING1, RAD51, FMR1, DLX2, POLE, SSRP1, EP300, FOXO1, CHAF1A, CHAF1B, TRIM28, MTA1, ORC1, NFATC2, SMAD4, RUNX2, HNRNPD, SMC1A, KIAA0101, NCAPD2, BRD3, NONO, ZMYND11, NCOA2, NCOA1, SMAD2, EZH2, PKN1, MSL1, NIPBL, ATAD2, SLC30A9, SMARCD3, TSHZ1, DHX30, TADA2B, PBRM1, SIRT2, FANCM, APITD1, NKAP, SETD7, HDAC7, JDP2, BAP1, HDAC2, CREBBP, EZH1, KAT2B, GATA6, MED12, CREB3L1, MBD6, CDCA5, ZNF274, SMARCD1, AJUBA, PRMT6, IFT74, PRIMPOL, PHF12, CIC, GPER1, MNT, MEIS3, ARID3A, CITED1, CITED2, PYGO2, WAC, NUCKS1, EBF2, PATZ1, CHD8, ENY2, UBE2T, ASH1L, TSHZ2, MBD5, CHD7, RERE, DNMT3B, UXT, MORF4L1, LRWD1, MLH3, TRPS1, BAZ1B, NAP1L2, EXO1, SMC3, HDAC5, ASF1A, NOC2L, L3MBTL1, LOXL2 |
GO:0003684 | MF | damaged DNA binding | Interacting selectively and non-covalently with damaged DNA. |
FANCG, RAD1, NBN, POLQ, TP53, ERCC1, HMGB1, PCNA, XRCC5, UNG, H2AFX, MSH3, XPA, HMGB2, POLD1, MPG, RPA3, BRCA1, FEN1, RAD23A, RAD23B, XPC, EP300, TDG, CUL4B, NEIL3, CREBBP, ERCC4, DCLRE1C, RAD18, POLK, POLI, POLH |
GO:0003688 | MF | DNA replication origin binding | Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
ORC5, HSPD1, MCM5, MCM2, MCM10, ORC3, ORC6 |
GO:0003689 | MF | DNA clamp loader activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. |
RFC4, RFC2, RFC5, RFC3, CHTF18, DSCC1 |
GO:0003690 | MF | double-stranded DNA binding | Interacting selectively and non-covalently with double-stranded DNA. |
STRA13, HMGB3, RAD51C, RAD51D, EGFR, TP53, HMGB1, XRCC5, HMGB2, RBMS1, CTNNB1, FEN1, MSH2, MRE11A, AFF3, MSH6, YBX1, PRKDC, NTHL1, SATB1, RAD51, TARDBP, TDG, ZNF638, SMAD2, CRY1, HLF, IFI16, APITD1, LSM14A, FBXO18, NEIL3, GTF2H4, RAD51AP1, MTERF1, MND1, NUCKS1, TDP1, SLTM, HES2 |
GO:0003691 | MF | double-stranded telomeric DNA binding | Interacting selectively and non-covalently with double-stranded telomere-associated DNA. |
XRCC5, TERF1, PURA, RAD50 |
GO:0003696 | MF | satellite DNA binding | Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA. |
MBD4, CENPB, MLH3 |
GO:0003697 | MF | single-stranded DNA binding | Interacting selectively and non-covalently with single-stranded DNA. |
POLR2D, RAD51C, RAD51D, TDP2, ANXA1, ERCC1, HMGB1, HNRNPA1, HSPD1, NME1, MSH3, HMGB2, RBMS1, MCM4, MCM7, RPA3, MLH1, LRPPRC, MSH2, BRCA2, SUB1, BLM, PMS1, RAD23A, RAD23B, POLR2G, YBX1, SSBP2, PURA, XPC, SSBP1, RAD51, MCM6, PCBP1, TSN, MCM10, NUP35, FBXO18, NEIL3, RTF1, ERCC4, FUBP1, NABP1, RAD51AP1, PURB, PEO1, NABP2, SSBP4, SSBP3, OBFC1, TDP1, MLH3 |
GO:0003700 | MF | transcription factor activity, sequence-specific DNA binding | Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
E2F8, ZNF320, ZNF879, FOXN3, NR5A2, BHLHE40, ZNF213, BACH1, IRF6, TFEC, BTAF1, SMAD7, SMAD9, FOXP2, MAFG, ZSCAN9, HOXA3, CBFA2T2, KLF4, FOXO3, SMAD6, ZNF207, SOX15, PARK2, KDM1A, CREBL2, GAS7, ZNF623, TSC22D2, ZNF217, TADA2A, TADA3, CAPN15, ZNF189, KLF7, NFAT5, ZNF205, ZRANB2, YEATS4, NFATC1, PTTG1, ZBED1, FOS, MYC, ESR1, NR3C1, MYCN, TP53, JUN, RB1, ZFY, NFIC, HOXC4, HMGB1, GLI2, GLI3, MYBL2, AR, NR2F1, THRA, EGR2, VDR, POU2F1, ETS1, ETS2, FOSL1, FOSL2, VAV1, ZNF250, TCF4, TCF3, CREB1, ZFX, ZNF12, ZNF19, ZNF182, ZNF23, ZNF24, ZKSCAN1, ZNF43, HMGA1, TAL1, ATF7, CEBPB, XBP1, EGR1, ATF1, ATF3, ATF4, ATF6, ELK1, TFEB, WT1, NFKB1, BCL3, HNF1A, NME2, NR2F2, NFYB, YY1, HMGB2, ARNT, HOXD10, MZF1, RXRB, KDM5A, HOXA6, HIVEP2, FOXN2, CTNNB1, RORA, DDIT3, SOX6, ZNF93, AHR, SREBF1, PPARG, ZEB1, PBX1, PBX2, STAT3, ID1, ETV5, BCL6, WNT5A, BUD31, ELK3, STAT5A, GATA4, NKX2-1, NOTCH1, ZFP36L2, RFX2, RFX5, SOX9, MEOX1, ETV1, ASCL1, ZNF83, STAT5B, STAT2, ZNF133, ZNF140, ZNF138, RCAN1, HIRA, MLLT10, PRDM15, KLF3, FOXL2, ZNF445, LMO4, YBX1, GTF2I, ELF3, SIM1, SMAD3, ZBED6, FOXO4, ZNF200, TFAM, HSF1, IRF9, E2F1, INSM1, RELB, POU5F1, BNC1, MEF2A, ID3, CREB5, POU3F1, CREM, PPARD, ZNF85, ZNF117, ZNF92, RELA, REL, MXD1, EGR4, ZNF91, MEF2C, GABPA, PAX8, ZNF33A, EGR3, SOX4, ZFP36L1, DLX2, PPARA, ZNF616, ZNF816, TFCP2, TCF15, FOXC1, TAF10, PRDM2, ZBTB17, KLF10, TARDBP, TRIM28, MTA1, ZNF211, IKZF1, NFATC2, SMAD4, HDAC1, RUNX3, KLF9, GTF2H2, RUNX2, CBFB, NFYC, TFDP1, SIM2, E2F2, TRIM25, HES1, NFE2L1, ZNF345, ZNF268, MEF2D, POU6F1, MTF1, DRAP1, TCEAL1, TAF5, TEAD4, TEAD2, TSC22D1, SMAD2, SMAD1, USF2, ZFHX3, ZIC1, TAF12, NFIL3, HIF1A, ZSCAN26, ZNF630, ZSCAN23, ZNF568, TAF1B, ZNF789, HIVEP3, ZNF658, PLAG1, ZNF585A, ZNF449, ZNF880, SLC30A9, ZNF600, ZNF621, ZNF534, SUPT6H, ZNF367, ZSCAN2, TADA2B, ZSCAN30, GPBP1, ZNF677, ZNF573, GATAD2A, CREBRF, AEBP1, MGA, TRIM22, ZFP82, ZNF567, ZNF808, ZNF655, ZNF283, ZNF615, ZNF565, ZBTB38, ZNF548, ZNF397, ZFP28, ZNF420, ZNF564, GATAD1, GLMP, ZNF606, ARNTL2, CSRNP3, AHCTF1, ESR2, GTF2H4, PROX1, CREBBP, GATA6, FUBP1, ZBED6CL, ZNF274, ZNF419, HES6, ZSCAN31, ZFP3, ZNF317, ZNF300, NR1H4, CSRNP1, ZNF607, ATOH8, ZNF382, UHRF1, TCF12, TSC22D3, MNT, TEAD3, PITX2, SMAD5, HNRNPAB, NPAS2, CITED1, CITED2, TCF25, ZNF2, SALL3, BACH2, FOXP3, ZNF436, CSRNP2, BLZF1, IKZF4, IKZF5, ZNF552, ZNF287, GPBP1L1, ZNF532, TCF7L1, ZNF334, HMG20A, MYNN, HEYL, TCF7L2, ZNF71, ZNF302, SLC2A4RG, TULP4, ZNF586, AATF, ZNF226, EHF, ZNF224, ZKSCAN7, ZNFX1, RCOR3, RERE, KDM5B, TCF20, MLX, AFF4, TRPS1, ZNF639, CNOT7, ZFP69B, ZNF112, NOCT, ZHX1, TCFL5, MYT1L, KMT2B, PHTF1, SCML1, PA2G4, SCML2, TCF19, LZTS1, MYRF, TSC22D4, L3MBTL1, ZNF175, NFE2L3, ZNF451, HEY1, KLF2 |
GO:0003705 | MF | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. |
MEIS1, NR5A2, BHLHE40, SNAI2, NFATC1, PTH, JUN, CREB1, CEBPB, ATF1, ARNT, NKX2-1, SOX9, PURA, MEF2A, RELA, FOXC1, TEAD2, USF2, ZFHX3, HIF1A, PROX1, GATA6, NR1H4, FOXP3, SOX17 |
GO:0003707 | MF | steroid hormone receptor activity | Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. |
NR5A2, PGRMC2, ESR1, PGR, NR2F1, THRA, VDR, ESRRA, NR1D1, NR4A1, NR2F2, RXRB, RORA, PPARG, NR4A2, NR0B1, NR1H2, PPARD, PPARA, NR1H3, NR1D2, NR0B2, PAQR8, NR4A3, ESR2, NR1H4, OR51E2, PAQR5 |
GO:0003712 | MF | transcription cofactor activity | Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. |
LDB2, MED14, LPXN, TADA2A, MUC1, CREB1, BTG1, TMF1, NRG1, MXD1, ZNF763, NMI, CBFB, NFE2L1, ZMYND11, TRIP13, ZNF667, KAT2B, MED12, MED30, HES6, NFKBIZ, MED4, MED17, THRAP3, MED16, TRRAP |
GO:0003713 | MF | transcription coactivator activity | Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
PDLIM1, AIP, ARID1A, TFEC, TGFB1I1, MED7, MED14, PQBP1, EDF1, TADA2A, SUPT3H, TADA3, MED6, KLF7, SUPT7L, BCL10, ACTL6A, JUN, RB1, NPM1, NR2F1, JUP, TCF3, ZFX, JUNB, JUND, DDX5, PSMC3, ATF6, MAK, SP100, YY1, ARNT, RXRB, KDM5A, CTNNB1, GTF2F1, FUS, ZEB1, BRCA1, GATA4, YAP1, NRIP1, CDK7, SMARCA2, SMARCA4, GTF2A1, GTF2A2, SUB1, CTBP2, ELF3, PPARD, GABPA, EP300, TAF10, NR1H3, MTA1, MED21, NCOA4, CBFB, NFYC, TFDP1, NPAT, LPIN1, ARID5B, MTF1, NFATC4, TAF11, NCOA2, TRIP11, NCOA1, SMARCD3, TADA2B, MTDH, CARM1, WWC1, CCAR1, YAF2, KMT2E, MAML2, JMY, ARID1B, SMARCC2, ESR2, CREBBP, KAT6A, KAT2B, DDX17, SMARCC1, RBPMS, MED12, TADA1, SMARCD1, MAML3, NR1H4, CITED4, MYCBP, MNT, CITED1, CITED2, HTATIP2, SOX17, MED20, SRA1, ENY2, BRD7, MED17, PPARGC1A, RNF14, TCF20, MKL2, GTF2A1L, USP22, THRAP3, MED16, NFE2L3, HCFC2, NCOA3 |
GO:0003714 | MF | transcription corepressor activity | Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. |
E2F8, SAP18, ZNF593, BHLHE40, TFEC, HDAC3, RBFOX2, SIAH2, CBFA2T2, TBL1X, NCOR1, PEX14, GMNN, HSBP1, CREG1, TDP2, SKI, JUNB, PSMC3, ATF3, NR1D1, SP100, NR2F2, YY1, YWHAB, DDIT3, ZEB1, ELK3, YAP1, ID4, NRIP1, MXI1, ERF, SMARCA4, NR0B1, ZNF136, HIRA, ATN1, HDAC4, CTBP2, SRSF2, RELB, DR1, ID3, ZNF85, MXD1, C1QBP, AES, GPS2, TRIM28, MTA1, C1D, TOB2, NPAT, MXD4, DRAP1, ZMYND11, ANKRD1, NR0B2, NFIL3, GON4L, ATF7IP, KCTD1, JAZF1, AEBP1, CCAR1, YAF2, TRIM22, DDX54, PPP1R13L, HDAC7, ZFPM2, PROX1, PBXIP1, ZNF274, TONSL, AJUBA, PAWR, NR1H4, TRIB3, PFDN5, MNT, CITED2, MYBBP1A, TBL1XR1, FOXP3, HIPK2, TAF9B, BRD7, HEYL, KMT5A, RLIM, LMCD1, RCOR3, DNMT3B, KDM5B, LIMD1, HDAC9, ZHX1, SUFU, CDYL, NOC2L, LOXL2, NCOR2, EID1 |
GO:0003720 | MF | telomerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. |
DKC1, TERF1, PTGES3, TEP1 |
GO:0003723 | MF | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
MIF4GD, IGF2BP3, RTCA, NOP56, DDX3X, RNASET2, XPO1, KHNYN, SYNJ2, RBFOX2, CTIF, HNRNPR, SYNJ1, NUDT21, AHCYL1, HBP1, SYNCRIP, DKC1, NOL3, DUSP11, PRPF40A, SRSF10, KHDRBS3, RNASEH2A, RSL1D1, UBR5, ZRANB2, CELF2, POP4, PTBP3, LSM8, NR3C1, NPM1, HNRNPC, SNRPA, CNP, HNRNPA1, TROVE2, HSP90B1, HNRNPL, RPL7, SON, WT1, RPS4Y1, HNRNPA2B1, EIF4B, YY1, PSMA1, DNMT1, RPL13, PTBP1, TARS, RBMS1, HNRNPH3, HNRNPH1, RPL22, FUS, RPL4, SRP14, RBMX, BRCA1, LRPPRC, RPL27A, RPL5, RPL21, RPL28, RPS5, RPL29, RPL34, SRP9, SARS, RANBP2, RPL14, PAPOLA, FXR1, NOVA1, NR0B1, HNRNPA3, HNRNPM, AGFG1, RBM5, MRPL12, HNRNPH2, PCBP4, RPS3A, RPL26, RPL15, RPL37, RPS7, RPS15A, RPS16, RPS14, SNRPF, LSM3, LSM6, SNRPD1, RPL7A, RPS25, RPL30, RPL31, RPL10A, RPL11, RPL41, SNRPN, RPL38, EIF5A, YBX1, RBM6, RPP30, RAE1, RPL24, RPL19, RBM3, HNRNPU, EWSR1, RPL18A, RNASEL, EXOSC9, FMR1, RPL18, KHDRBS1, SRSF1, NCBP1, GRSF1, SF3A3, ILF3, CSTF3, TARDBP, SRSF6, IFIT5, C1D, HNRNPD, MORC3, FASTK, CAPRIN1, PUM1, ZNF638, SUZ12, EXOSC7, PCBP1, RBMS2, ELAVL1, MRPL23, TIMM50, PABPC1L, PDCD4, ZNF385B, NOM1, ZMAT1, DDX60L, EARS2, RBM48, THOC7, MRM1, JMJD6, RBM43, PARS2, NUFIP2, PABPN1, PPARGC1B, DCP2, RBM45, ZC3H3, SUPV3L1, ARHGEF28, AGGF1, CPEB3, PUM2, ZCRB1, TRUB1, NANOS1, GTF3A, AKAP1, DDX17, EMG1, RBPMS, NABP1, RAD51AP1, RPL39L, DAZAP1, NAF1, RBM17, THOC3, YTHDC1, ZMAT2, BARD1, HNRNPAB, TEP1, LARP6, HNRNPUL1, RBM4, PAPOLG, MRPL4, MRPL1, NIFK, PUS3, CRNKL1, PAIP1, UPF3A, PHAX, LIN28A, UPF2, APOBEC3G, CWC22, TNRC6C, EXOSC3, MBNL1, RBFOX1, CDKN2AIP, DDX43, CWC15, CPSF2, PPARGC1A, NUFIP1, CNOT7, LSM7, CNOT6, PPIE, NOVA2, SCAF8, DIS3, RCL1, LSM2, RBMX2, SAMHD1, KIAA0430, LSM5, CSDC2, RBM8A |
GO:0003724 | MF | RNA helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. |
DHX15, DHX16, FSBP, DDX5, SKIV2L2, DDX17, DDX24, RAD54B |
GO:0003725 | MF | double-stranded RNA binding | Interacting selectively and non-covalently with double-stranded RNA. |
TLR3, DHX15, PRKRA, STAU1, TFRC, SLC3A2, HSP90AB1, VIM, HSPD1, ACTN1, EIF4A1, TUBA1B, TUBB4B, ILF2, ILF3, RFTN1, ELAVL1, LRRFIP1, DHX30, MTDH, SUPV3L1, LSM14A, STRBP, DHX36, MRPL44, AGO4, MBNL1, STAU2, AGO2, DICER1, MYH4 |
GO:0003726 | MF | double-stranded RNA adenosine deaminase activity | Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule. |
ADARB1 |
GO:0003727 | MF | single-stranded RNA binding | Interacting selectively and non-covalently with single-stranded RNA. |
POLR2D, CBX7, ANXA1, SNRPC, HNRNPA1, ZFP36, POLR2G, DLX2, IFIT5, LACTB2, JMJD6, LSM14A, STRBP, AGO4, NXF1, AGO2 |
GO:0003729 | MF | mRNA binding | Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
RBFOX2, NUDT21, DXO, LUC7L3, DHFR, TYMS, SSB, HSP90AA1, SNRPC, TPR, RPS2, RPL7, ZFP36, CALR, RBMX, RPL13A, RPL35, RPS5, RBM25, FXR1, NOVA1, HNRNPA3, RBM5, EIF4A1, RPS13, RPS26, TRA2B, ADARB1, FMR1, C1QBP, ZFP36L1, SRSF1, GRSF1, CSTF3, G3BP1, EIF3A, SLBP, PCBP1, PUM3, TSN, ELAVL1, SNRNP35, NCBP3, SAMD4B, RBPMS2, THOC2, UHMK1, NUDT16, EDC3, QKI, PURB, HNRNPAB, PAIP2, RBM4, RBM38, ESRP2, RC3H2, METTL14, LUC7L, EIF4ENIF1, RBFOX1, NXF1, NOCT, PTBP2, AGO2, G3BP2, SAMD4A, LUC7L2, RBM8A |