GO:0030791

MF

arsenite methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.

AS3MT

GO:0030792

MF

methylarsonite methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.

AS3MT

GO:0030881

MF

beta-2-microglobulin binding

Interacting selectively and non-covalently with beta-2-microglobulin.

HLA-E, CD1D, HLA-A, HFE

GO:0030882

MF

lipid antigen binding

Interacting selectively and non-covalently with a lipid antigen.

CD1D

GO:0030883

MF

endogenous lipid antigen binding

Interacting selectively and non-covalently with an endogenous cellular lipid antigen.

CD1D

GO:0030884

MF

exogenous lipid antigen binding

Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids).

CD1D

GO:0030898

MF

actin-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.

MYO1C, MYO1D, MYH9, MYL6, MYO10

GO:0030911

MF

TPR domain binding

Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices.

HSP90AA1, HSP90AB1, RAB8B, STUB1

GO:0030942

MF

endoplasmic reticulum signal peptide binding

Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.

SRP14, SRP54

GO:0030943

MF

mitochondrion targeting sequence binding

Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.

TOMM20

GO:0030955

MF

potassium ion binding

Interacting selectively and non-covalently with potassium (K+) ions.

PDXK, ATP1B1, PKM, ATP1A2, HDAC4, KCNJ11, SLC24A3

GO:0030957

MF

Tat protein binding

Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.

NPM1, DNAJA1, SMARCA4, ACTB, GABARAPL1

GO:0030971

MF

receptor tyrosine kinase binding

Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.

ANGPT2, SOCS5, ZPR1, TP53, PCNA, PTPN2, MST1, RACK1, SHC2, NRG1, PTPN11, HYAL2, TIAM1, CBLB, SQSTM1, EIF3A, GAS6, ANGPT1, ARHGEF16, FAM150B

GO:0030975

MF

thiamine binding

Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

TPK1

GO:0030976

MF

thiamine pyrophosphate binding

Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

ILVBL, OGDH

GO:0030983

MF

mismatched DNA binding

Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches.

MSH3, MSH2, MSH6, PMS1, TDG, MLH3

GO:0030984

MF

kininogen binding

Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors.

C1QBP

GO:0031005

MF

filamin binding

Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.

DPYSL4, NEBL, DPYSL3, FAM101A, FAM101B, FBLIM1, PDLIM2

GO:0031014

MF

troponin T binding

Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.

TNNT1, TNNI3

GO:0031072

MF

heat shock protein binding

Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.

GPR37, PARK2, DNAJA2, DNAJB6, HSPA1A, HSPA1B, TPR, HSPA6, ZFP36, ADORA1, HSPA1L, IRAK1, TFAM, HSF1, OGDH, FKBP4, PPID, DMPK, FKBP5, KCNJ11, CDC37, DNAJA4, DNAJC9, HDAC2, PACRG, DNAJC7, FAF1

GO:0031177

MF

phosphopantetheine binding

Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).

FASN

GO:0031208

MF

POZ domain binding

Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.

CUL3

GO:0031210

MF

phosphatidylcholine binding

Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.

ESYT2, CHMP2A, APOA1, APOA2, APOC1, SERPINA5, PCYT1A, PITPNA, APOA5, PCTP

GO:0031267

MF

small GTPase binding

Interacting selectively and non-covalently with a small monomeric GTPase.

ABCA1, FLNA, TSC2, GDI2, FGD6, FGD2, RNF152, FGD4, ERRFI1

GO:0031369

MF

translation initiation factor binding

Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.

DDX3X, POLR2D, ZPR1, EIF3B, POLR2G, FMR1, EIF2B5, LARP1, SYT11, LIN28A, EIF2B4, TBL2

GO:0031370

MF

eukaryotic initiation factor 4G binding

Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.

EIF4E

GO:0031386

MF

protein tag

Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question.

ISG15, SUMO3, SUMO2, SUMO4, NFATC2IP

GO:0031402

MF

sodium ion binding

Interacting selectively and non-covalently with sodium ions (Na+).

PDXK, ATP1B1, CAPN3, ATP1A2, SCN9A, SLC24A3

GO:0031403

MF

lithium ion binding

Interacting selectively and non-covalently with lithium ions (Li+).

PDXK, IMPA1

GO:0031404

MF

chloride ion binding

Interacting selectively and non-covalently with chloride ions (Cl-).

ACE, CLCN3, CLCN4, CLCN5, CLCN6, CLCN7, CLCNKA, CLCNKB, CTSC, NLGN4X

GO:0031406

MF

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

PCK1, HMGCL, AKR1C2, AKR1C1, GRHPR

GO:0031418

MF

L-ascorbic acid binding

Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.

PLOD2, P4HA2, P4HA1, PAM, PLOD1, OGFOD3, P3H2, EGLN3

GO:0031419

MF

cobalamin binding

Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

MTR, CD320, LMBRD1

GO:0031432

MF

titin binding

Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.

CAPN3, ACTN2, CALM2, MYBPC1, CAMK2D, ANKRD1

GO:0031433

MF

telethonin binding

Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.

BMP10, TTN, MYOZ1

GO:0031434

MF

mitogen-activated protein kinase kinase binding

Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.

RAF1, ACE, IGBP1, DLG1, TRIB2, TRIB3, TRIB1, TAOK2, MAPK8IP3, MAPK8IP1

GO:0031435

MF

mitogen-activated protein kinase kinase kinase binding

Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.

TCF3, MAPK1, TGFBR2, CDC42, STK38, DUSP19, MARVELD3, MAPK8IP3, MAPK8IP1

GO:0031489

MF

myosin V binding

Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.

RAB27B, RAB3B, FUS, RAB27A, RAB11A, RAB11B, RAB39B, RAB6B

GO:0031490

MF

chromatin DNA binding

Interacting selectively and non-covalently with DNA that is assembled into chromatin.

PER1, KDM6A, FOXO3, ACTN4, H2AFY, H2AFZ, HIST1H1E, THRA, HIST1H1C, KDM5A, STAT3, BCL6, NOTCH1, SMAD3, INSM1, HIST1H1A, RELA, EP300, SUZ12, JMJD1C, EZH2, NKAP, WBP2, PITX2, GRHL1, H2AFY2, PPARGC1A, RUVBL2

GO:0031491

MF

nucleosome binding

Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.

ARID1A, ZNHIT1, SMARCA5, SMARCA1, RNF169, DNTTIP1, NOC2L, L3MBTL1, CABIN1

GO:0031492

MF

nucleosomal DNA binding

Interacting selectively and non-covalently with the DNA portion of a nucleosome.

HMGN4, H2AFY, MBD3, ACTL6A, HMGN2, HNRNPC, H2AFZ, RCC1, CENPA, SMARCA4, HMGA2, ACTB, HIST1H3D, H3F3A, RBBP4, HDAC1, CHD4, SMARCC2, HDAC2, SMARCC1

GO:0031493

MF

nucleosomal histone binding

Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.

UHRF1, VRK1, L3MBTL1

GO:0031545

MF

peptidyl-proline 4-dioxygenase activity

Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2.

EGLN3

GO:0031593

MF

polyubiquitin binding

Interacting selectively and non-covalently with a polymer of ubiqutin.

EPS15, BRCC3, RAD23A, RAD23B, VCP, FAM175B, ZFAND6, FAAP20, OPTN, UBQLN4, RAD18, HDAC6

GO:0031624

MF

ubiquitin conjugating enzyme binding

Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.

SIAH2, PARK2, RNF144A, FOXL2, PPARA, RNF19B, RNF144B, DCUN1D4, RASD2, DCUN1D1, TOLLIP, RNF19A, RNF14, ZMYM2, ARIH1, RNF114

GO:0031625

MF

ubiquitin protein ligase binding

Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.

TMEM189, ASB14, WASH1, UBE2C, AURKA, SMAD7, AXIN1, MID1, GPR37, PER1, SMAD6, PARK2, FZD6, EIF4E2, NDUFS2, USP2, RNF8, UBXN7, ERLIN2, TRIM37, MFN2, BCL10, EGFR, TP53, SLC25A5, RB1, GPI, TUBB, LYN, NGFR, UCHL1, HSPA1A, HSPA1B, BCL2, PRKAR1A, HSPD1, CLU, HSPA5, EGR2, DBT, RALA, RALB, CKB, SKI, XRCC5, PRKAR2A, PRKACA, TCP1, ATF6, TNFRSF1B, JAK1, POLR2A, CALR, PRDX6, PRKAR2B, DNAJA1, UQCRC1, MC4R, HSPA1L, CBS, ACVR1B, LTBR, BRCA1, CDKN1A, LRPPRC, RANGAP1, CDC34, UBE2A, FHIT, GSK3B, ATXN3, VCP, BID, TPI1, GABARAPL2, CXCR4, SUMO2, UBE2H, YWHAE, RBX1, YWHAZ, UBE2B, ACTG1, TUBA1B, CCT2, SMAD3, MDM2, POU5F1, RELA, FOXO1, KCNH2, TRAF1, TRIM28, UBE2V1, SQSTM1, RIPK1, NAE1, CUL2, CUL3, CUL4A, CUL4B, CASP8, CUL7, SHPRH, TCEB2, SMAD2, UBE2V2, NEDD8, HIF1A, UBE2S, SPOPL, CACUL1, CCDC50, SLF2, SPG20, UBE2J2, ABTB2, HM13, ZNF675, RFFL, TRIB2, DIO2, TANK, GLMN, USP13, CUL5, UBE2W, SLC22A18, MOAP1, FAF2, OTUB1, PACRG, ASB16, BTBD9, TRIB3, TRIB1, SMC6, MPHOSPH8, SMAD5, SLF1, SYT11, PINK1, MAP1LC3B, TOLLIP, GABARAPL1, TRIOBP, BLZF1, TXNIP, FZD8, MAP1LC3A, UBE2Z, AKTIP, UBE2T, RAD18, KBTBD4, ABI2, JKAMP, NLK, PPARGC1A, HDAC6, USP25, BAG5, FZD4, STUB1, FAF1, SMG5, PA2G4, BTBD3, PTPN22, ARIH1, ASB3, SNX9, SNCAIP

GO:0031626

MF

beta-endorphin binding

Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin.

IDE

GO:0031628

MF

opioid receptor binding

Interacting selectively and non-covalently with an opioid receptor.

PENK

GO:0031681

MF

G-protein beta-subunit binding

Interacting selectively and non-covalently with a G-protein beta subunit.

F2R, RGS7, F2RL1, RASD2

GO:0031683

MF

G-protein beta/gamma-subunit complex binding

Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits.

GNAI2, GNAI3, GNA11, ADORA1, GNAQ, GNAI1, GNAS, GNA12, GNAS

GO:0031690

MF

adrenergic receptor binding

Interacting selectively and non-covalently with an adrenergic receptor.

C1QBP

GO:0031694

MF

alpha-2A adrenergic receptor binding

Interacting selectively and non-covalently with an alpha-2A adrenergic receptor.

ADRB1, UCHL1

GO:0031697

MF

beta-1 adrenergic receptor binding

Interacting selectively and non-covalently with a beta-1 adrenergic receptor.

DLG4, MAGI2

GO:0031698

MF

beta-2 adrenergic receptor binding

Interacting selectively and non-covalently with a beta-2 adrenergic receptor.

GNAS, PDE4D, GNAS

GO:0031699

MF

beta-3 adrenergic receptor binding

Interacting selectively and non-covalently with a beta-3 adrenergic receptor.

ADRB3, ARRDC3

GO:0031700

MF

adrenomedullin receptor binding

Interacting selectively and non-covalently with an adrenomedullin receptor.

ADM

GO:0031702

MF

type 1 angiotensin receptor binding

Interacting selectively and non-covalently with a type 1 angiotensin receptor.

JAK2, AGT, GNB1, ARAP1

GO:0031703

MF

type 2 angiotensin receptor binding

Interacting selectively and non-covalently with a type 2 angiotensin receptor.

AGT

GO:0031704

MF

apelin receptor binding

Interacting selectively and non-covalently with an apelin receptor.

APLN

GO:0031707

MF

endothelin A receptor binding

Interacting selectively and non-covalently with an endothelin A receptor.

EDN1

GO:0031708

MF

endothelin B receptor binding

Interacting selectively and non-covalently with an endothelin B receptor.

EDN1, EDN2

GO:0031710

MF

neuromedin B receptor binding

Interacting selectively and non-covalently with a neuromedin B receptor.

NMB

GO:0031711

MF

bradykinin receptor binding

Interacting selectively and non-covalently with a bradykinin receptor.

ACE, AGTR1

GO:0031715

MF

C5L2 anaphylatoxin chemotactic receptor binding

Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor.

C3

GO:0031716

MF

calcitonin receptor binding

Interacting selectively and non-covalently with a calcitonin receptor.

RAMP1

GO:0031720

MF

haptoglobin binding

Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.

HBB, HBA1

GO:0031726

MF

CCR1 chemokine receptor binding

Interacting selectively and non-covalently with a CCR1 chemokine receptor.

CCL3, CCL4, CCL5

GO:0031727

MF

CCR2 chemokine receptor binding

Interacting selectively and non-covalently with a CCR2 chemokine receptor.

CCL2

GO:0031729

MF

CCR4 chemokine receptor binding

Interacting selectively and non-covalently with a CCR4 chemokine receptor.

CCL5

GO:0031730

MF

CCR5 chemokine receptor binding

Interacting selectively and non-covalently with a CCR5 chemokine receptor.

CCL3, CCL4, CCL5, JAK1, STAT3

GO:0031731

MF

CCR6 chemokine receptor binding

Interacting selectively and non-covalently with a CCR6 chemokine receptor.

CCL20

GO:0031741

MF

type B gastrin/cholecystokinin receptor binding

Interacting selectively and non-covalently with a type B gastrin/cholecystokinin receptor.

CCKBR

GO:0031748

MF

D1 dopamine receptor binding

Interacting selectively and non-covalently with a D1 dopamine receptor.

DLG4, GNAS, PTPN11, GNAS, VPS35

GO:0031752

MF

D5 dopamine receptor binding

Interacting selectively and non-covalently with a D5 dopamine receptor.

GNA12

GO:0031755

MF

Edg-2 lysophosphatidic acid receptor binding

Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor.

RALA

GO:0031764

MF

type 1 galanin receptor binding

Interacting selectively and non-covalently with a type 1 galanin receptor.

GAL

GO:0031765

MF

type 2 galanin receptor binding

Interacting selectively and non-covalently with a type 2 galanin receptor.

GAL

GO:0031766

MF

type 3 galanin receptor binding

Interacting selectively and non-covalently with a type 3 galanin receptor.

GAL

GO:0031768

MF

ghrelin receptor binding

Interacting selectively and non-covalently with a ghrelin receptor.

GHRL

GO:0031769

MF

glucagon receptor binding

Interacting selectively and non-covalently with a glucagon receptor.

GCG

GO:0031770

MF

growth hormone-releasing hormone receptor binding

Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor.

GHRH

GO:0031773

MF

kisspeptin receptor binding

Interacting selectively and non-covalently with a kisspeptin receptor.

KISS1

GO:0031775

MF

lutropin-choriogonadotropic hormone receptor binding

Interacting selectively and non-covalently with a lutropin-choriogonadotropic hormone receptor.

ATP2A2

GO:0031780

MF

corticotropin hormone receptor binding

Interacting selectively and non-covalently with a corticotropin hormone receptor.

MRAP, MRAP2

GO:0031781

MF

type 3 melanocortin receptor binding

Interacting selectively and non-covalently with a type 3 melanocortin receptor.

POMC, MRAP, MRAP2

GO:0031782

MF

type 4 melanocortin receptor binding

Interacting selectively and non-covalently with a type 4 melanocortin receptor.

POMC, MRAP, MRAP2

GO:0031783

MF

type 5 melanocortin receptor binding

Interacting selectively and non-covalently with a type 5 melanocortin receptor.

MRAP, MRAP2

GO:0031800

MF

type 3 metabotropic glutamate receptor binding

Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor.

CALM2

GO:0031812

MF

P2Y1 nucleotide receptor binding

Interacting selectively and non-covalently with a P2Y1 nucleotide receptor.

DLG4

GO:0031821

MF

G-protein coupled serotonin receptor binding

Interacting selectively and non-covalently with a metabotropic serotonin receptor.

GNAI3, GNAI1

GO:0031826

MF

type 2A serotonin receptor binding

Interacting selectively and non-covalently with a type 2A serotonin receptor.

GNA11, GNAQ

GO:0031849

MF

olfactory receptor binding

Interacting selectively and non-covalently with an olfactory receptor.

REEP1

GO:0031852

MF

mu-type opioid receptor binding

Interacting selectively and non-covalently with a mu-type opioid receptor.

FLNA, GNAS, GNAS, WLS

GO:0031856

MF

parathyroid hormone receptor binding

Interacting selectively and non-covalently with a parathyroid hormone receptor.

PTH

GO:0031857

MF

type 1 parathyroid hormone receptor binding

Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor.

PTH

GO:0031867

MF

EP4 subtype prostaglandin E2 receptor binding

Interacting selectively and non-covalently with an EP4 subtype prostaglandin E2 receptor.

FEM1A

GO:0031871

MF

proteinase activated receptor binding

Interacting selectively and non-covalently with a proteinase activated receptor.

PHB, PDCD6IP, BICD1

GO:0031957

MF

very long-chain fatty acid-CoA ligase activity

Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22.

SLC27A2, ACSL4, SLC27A4, SLC27A1, SLC27A6

GO:0031994

MF

insulin-like growth factor I binding

Interacting selectively and non-covalently with insulin-like growth factor I.

ITGB3, INSR, ITGAV, IGF1R, IGFBP1, ITGB4, IGFBP3, IGFBP2, IGFBP4, ITGA6, IGFBP6, IGFBP5

GO:0031995

MF

insulin-like growth factor II binding

Interacting selectively and non-covalently with insulin-like growth factor II.

INSR, IGFBP1, IGF2R, IGFBP3, IGFBP2, IGFBP4, IGFBP6, IGFBP5