GO:0019981

MF

interleukin-6 binding

Interacting selectively and non-covalently with interleukin-6.

IL6R, IL6ST

GO:0019983

MF

interleukin-9 binding

Interacting selectively and non-covalently with interleukin-9.

IL9R

GO:0019992

MF

diacylglycerol binding

Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids.

RASGRP2

GO:0020037

MF

heme binding

Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

BACH1, PGRMC2, CYP27B1, CYB5B, CYP26A1, JAK2, STC2, CYB5A, AMBP, CYP1A1, CYBB, CYP17A1, CYP11A1, MPO, CYP2E1, CYC1, CYP3A4, CYP21A2, HMOX1, CYP2D6, CYP2A6, CYP19A1, CYP2C9, CYP11B1, CYP11B2, NR1D1, CYP2B6, CYP3A5, PTGS1, CYP3A7, NOS3, PTGS2, CBS, SUOX, HBB, HBG1, HBA1, CYCS, PTGIS, CYP1B1, CYP51A1, CYP2R1, CYP4V2, FA2H, CYP2U1, CYP2W1, CYB5D2, CYGB, NOX5, SDHC, CYP3A43, ABCB6, NGB, NOX4, CYP26B1, DUOX2, DUOX1, CYP8B1, FLVCR2

GO:0022839

MF

ion gated channel activity

Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus.

ASIC2

GO:0022840

MF

leak channel activity

Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.

PANX1

GO:0022841

MF

potassium ion leak channel activity

Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.

KCNK1, KCNK3, KCNK17, KCNK12, KCNK6

GO:0022843

MF

voltage-gated cation channel activity

Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

PKD2

GO:0022848

MF

acetylcholine-gated cation channel activity

Enables the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts.

CHRNA7

GO:0022857

MF

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

ATP5H, ATP5L, ATP5J, ATP5D, ATP5C1, ATP5O, ATP5E, ATP5I, SEC61A1, RALBP1, NDUFAF6, SLC18B1, SV2A, SV2B

GO:0023024

MF

MHC class I protein complex binding

Interacting selectively and non-covalently with the class I major histocompatibility complex.

KLRC1

GO:0023026

MF

MHC class II protein complex binding

Interacting selectively and non-covalently with the class II major histocompatibility complex.

HLA-DRA, CD74, ATP1B1, HSP90AA1, HSP90AB1, HLA-DOB, PKM, HLA-DMB, ANXA11, CD81, YWHAE

GO:0030020

MF

extracellular matrix structural constituent conferring tensile strength

A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.

COL11A2, COL9A1, COL12A1

GO:0030023

MF

extracellular matrix constituent conferring elasticity

A component of the extracellular matrix that enables the matrix to recoil after transient stretching.

FBN1, FBN2, EMILIN2

GO:0030060

MF

L-malate dehydrogenase activity

Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.

MDH1, MDH2, MDH1B

GO:0030107

MF

HLA-A specific inhibitory MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.

LILRB1

GO:0030108

MF

HLA-A specific activating MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte.

CTSH

GO:0030109

MF

HLA-B specific inhibitory MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte.

LILRB1

GO:0030144

MF

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors.

MGAT5B

GO:0030145

MF

manganese ion binding

Interacting selectively and non-covalently with manganese (Mn) ions.

PPM1B, LARGE, TDP2, SOD2, NUDT7, B4GALT1, LAP3, IMPA1, PCK1, HMGCL, ABL2, MRE11A, PAPOLA, NEK4, GALNT2, GALNT1, DCP2, FAM20C, XXYLT1, DYRK2, NUDT16, PRIMPOL, ATP13A2, XPNPEP3, MTPAP

GO:0030151

MF

molybdenum ion binding

Interacting selectively and non-covalently with molybdenum (Mo) ions.

SUOX, MARC1, MOCOS

GO:0030156

MF

benzodiazepine receptor binding

Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR).

DBI

GO:0030158

MF

protein xylosyltransferase activity

Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate.

XYLT2

GO:0030159

MF

receptor signaling complex scaffold activity

Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.

AXIN1, SPAG9, NUP62, LDLRAP1, MAGI2, DLG5, CARD10, G3BP2, MAPK8IP3

GO:0030165

MF

PDZ domain binding

Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.

PARK2, FZD7, SLC22A5, ADRB1, CFTR, GJA1, ATP2B1, ATP2B4, ACVR2A, SDC2, MAP2K2, NSF, PSEN1, CLCN3, PTEN, GNG5, CXADR, DLG4, ADAM17, TGFBR3, SNTA1, SNTB1, KIF14, ACOX1, ARHGAP29, ARHGEF16, ERC1, NLGN1, EXOC4, CADM1, FZD8, LIN7B, PLEKHA2, LIN7C, CRIM1, MPP6, CRIPT, ASIC3, KIDINS220, FZD4, DTNA, F11R

GO:0030169

MF

low-density lipoprotein particle binding

Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.

LDLR, CRP, THBS1, CD36, CDH13, SCARF1, COLEC12, PCSK9, SCARB1, STAB2, SORL1, STAB1

GO:0030170

MF

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

PDXK, SPTLC2, PROSC, GOT2, ALB, PYGB, PYGM, AGXT, CTH, SHMT1, CBS, BCAT1, ABAT, KYNU, MARC1, THNSL2, PHYKPL, THNSL1, GPT2, MOCOS, CSAD

GO:0030172

MF

troponin C binding

Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex.

TNNI3

GO:0030197

MF

extracellular matrix constituent, lubricant activity

Functions as a lubricant for an extracellular matrix, such as a mucous membrane.

MUC3A, MUC4

GO:0030215

MF

semaphorin receptor binding

Interacting selectively and non-covalently with semaphorin receptors.

SEMA3E, SEMA3D, SEMA3B, SEMA5A, SEMA3A, SEMA6D, SEMA3C, SH3BGRL3, SEMA6A, SEMA4A, SEMA6B

GO:0030229

MF

very-low-density lipoprotein particle receptor activity

Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.

LDLR, VLDLR, APOBR

GO:0030233

MF

deoxynucleotide transmembrane transporter activity

Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP.

SLC25A19

GO:0030234

MF

enzyme regulator activity

Binds to and modulates the activity of an enzyme.

PSMD3, APOC3, BRCC3, GCLM, PSMD2, SEPT2, PPP1R7, RGN, MTMR9, RAB3GAP2, ATP6V1H

GO:0030235

MF

nitric-oxide synthase regulator activity

Modulates the activity of nitric oxide synthase.

EGFR, ESR1, HSP90AA1, HSP90AB1, AKT1, CALM2

GO:0030246

MF

carbohydrate binding

Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.

LGALS8, MAN2B1, NCAN, MGAM, LY75, ADGRL2, APCS, KRT1, CLEC3B, C4A, C4B, GAA, VCAN, PRG2, SELL, LGALS3, CD33, MAG, ZP3, KLRC1, CALR, CANX, CHI3L1, LGALS7, NPTX2, MAN2A2, EVA1C, PRPS1, OLR1, PKD1, SORD, GBE1, GFPT1, MGAT2, GALNT2, GALNT1, CNTN1, OS9, MLEC, GANAB, NOMO1, NECTIN1, UAP1, LGALSL, ATRNL1, GALNT5, GALNT7, GALNT10, CD302, GALNT15, GALNT4, ITLN1, CLEC4D, CLEC2B, GALNT14, BCAN, SIGLEC11, CLEC7A, SIGLEC1, CHODL, ADGRL3, CD248, CD209, CD93, LGALS13, SIGLEC7, MAN2B2, AIM1

GO:0030247

MF

polysaccharide binding

Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.

ENPP3, VTN, ENPP1, AGL, ENPP2, SBSPON, PRG4, TINAGL1

GO:0030267

MF

glyoxylate reductase (NADP) activity

Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.

GRHPR

GO:0030272

MF

5-formyltetrahydrofolate cyclo-ligase activity

Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate.

MTHFS

GO:0030274

MF

LIM domain binding

Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.

RIPK2, LDB2, ACTN2, CSRP2BP, RPH3AL, TLN1

GO:0030275

MF

LRR domain binding

Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein.

KRAS, POLR2J, STK11, LRRFIP2

GO:0030276

MF

clathrin binding

Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.

HIP1, SYT1, NCALD, AP2B1, PICALM, LDLRAP1, AFTPH, DNER, SYTL5, SYTL4, SYT11, SYTL2, RPH3AL, TRPC6

GO:0030283

MF

testosterone dehydrogenase [NAD(P)] activity

Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+.

HSD17B10

GO:0030284

MF

estrogen receptor activity

Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.

ESR1, ESR2, GPER1

GO:0030290

MF

sphingolipid activator protein activity

Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.

GM2A

GO:0030291

MF

protein serine/threonine kinase inhibitor activity

Stops, prevents or reduces the activity of a protein serine/threonine kinase.

SPRY2, H2AFY, SPRED1, CIB1, WNK1

GO:0030292

MF

protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a protein tyrosine kinase.

RACK1

GO:0030294

MF

receptor signaling protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.

HYAL2

GO:0030295

MF

protein kinase activator activity

Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

RPLP1, MT3, PIK3CA, STK11, DBF4B, DUSP19, FGF13, WNK1, RGCC, GPRC5B, CAB39

GO:0030296

MF

protein tyrosine kinase activator activity

Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.

ERBB3, CD24, PAK2, GAS6, ABI1, AFAP1L2, GHRL

GO:0030297

MF

transmembrane receptor protein tyrosine kinase activator activity

Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.

GREM1, EFNA5, NRG1

GO:0030298

MF

receptor signaling protein tyrosine kinase activator activity

Binds to and increases the activity of a receptor signaling protein tyrosine kinase.

CCL5, FAM150B

GO:0030305

MF

heparanase activity

Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains.

HPSE

GO:0030306

MF

ADP-ribosylation factor binding

Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells.

RAB11FIP3, ADCYAP1R1, SORL1, GGA2

GO:0030331

MF

estrogen receptor binding

Interacting selectively and non-covalently with an estrogen receptor.

CNOT1, PARP1, PCNA, DDX5, CTNNB1, FUS, PPARG, NRIP1, FOXL2, PPID, TAF10, NCOA1, WIPI1, PPARGC1B, DDX54, DDX17, RERG, PHB2, PAGR1, PPARGC1A

GO:0030332

MF

cyclin binding

Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.

HDAC3, USP2, CDK1, CDK4, CDK2, CDKN1A, CDK6, INSM1, CUL3, PTCH1, CDK13, FBXO31, CDK12

GO:0030337

MF

DNA polymerase processivity factor activity

An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.

PCNA, TEFM

GO:0030343

MF

vitamin D3 25-hydroxylase activity

Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.

CYP3A4, CYP2R1

GO:0030346

MF

protein phosphatase 2B binding

Interacting selectively and non-covalently with the enzyme protein phosphatase 2B.

ATP2B4, BAD

GO:0030348

MF

syntaxin-3 binding

Interacting selectively and non-covalently with the SNAP receptor syntaxin-3.

STXBP2

GO:0030351

MF

inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity

Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.

MINPP1

GO:0030368

MF

interleukin-17 receptor activity

Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL17RB

GO:0030369

MF

ICAM-3 receptor activity

Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.

ITGB2

GO:0030371

MF

translation repressor activity

Antagonizes ribosome-mediated translation of mRNA into a polypeptide.

FMR1, EIF4EBP1, EIF4EBP2, CIRBP, SAMD4B, NANOS1, PAIP2, SAMD4A

GO:0030374

MF

ligand-dependent nuclear receptor transcription coactivator activity

The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.

ACTN4, MED14, KDM1A, TADA3, PRKCB, FGF2, ACTN1, HMGA1, PPARG, BUD31, NCOA2, NCOA1, PKN1, DCAF6, SLC30A9, CARM1, PPARGC1B, CCAR1, ZMIZ2, NCOA7, GLMP, MED12, MED30, HELZ2, SRA1, ENY2, MED4, MED17, PSMC3IP, PPARGC1A, USP22, THRAP3, NCOA3

GO:0030375

MF

thyroid hormone receptor coactivator activity

The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.

ACTN2, NCOA2, MED16

GO:0030377

MF

urokinase plasminogen activator receptor activity

Combining with the urokinase plasminogen activator to initiate a change in cell activity.

PLAUR

GO:0030395

MF

lactose binding

Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.

LGALS1, LGALS12

GO:0030414

MF

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

SSPO, PI15, PTTG1, PI16, PROL1

GO:0030429

MF

kynureninase activity

Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine.

KYNU

GO:0030492

MF

hemoglobin binding

Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.

HP, HBB

GO:0030504

MF

inorganic diphosphate transmembrane transporter activity

Enables the transfer of inorganic diphosphate across a membrane.

ANKH

GO:0030506

MF

ankyrin binding

Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.

SPTBN1, FLNC, KCNJ11, KCTD6, NRCAM, SPTBN4, RHBG

GO:0030507

MF

spectrin binding

Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.

DYNC1I1, GNB3, GBP1, GNB1, ANK2, CAMSAP2, ANK3, DCTN2, CAMSAP1, SPTBN4, MYO10, CAMSAP3, KIF3A

GO:0030515

MF

snoRNA binding

Interacting selectively and non-covalently with small nucleolar RNA.

NOP56, NUDT7, NUDT1, SNU13, TBL3, NUDT16, NUFIP1, NUDT5, WDR3

GO:0030544

MF

Hsp70 protein binding

Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size.

GPR37, PARK2, ERN1, CDK1, CREB1, DNAJB1, DNAJA1, STIP1, NUP62, CDKN1B, MVD, PPID, C11orf73, DNAJC10, METTL21A, PACRG, HDAC8, IQCG, STUB1

GO:0030546

MF

receptor activator activity

The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.

IGF2, ANXA2, PPARGC1B

GO:0030547

MF

receptor inhibitor activity

The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased.

PCSK9

GO:0030549

MF

acetylcholine receptor activator activity

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.

CDK5

GO:0030550

MF

acetylcholine receptor inhibitor activity

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased.

LYPD1

GO:0030551

MF

cyclic nucleotide binding

Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.

CNP

GO:0030552

MF

cAMP binding

Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).

PRKAR1A, PRKAR2A, PRKAR2B, PDE4D, PDE3A, BVES, RAPGEF4, POPDC3

GO:0030553

MF

cGMP binding

Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).

PDE5A, CNGA1

GO:0030554

MF

adenyl nucleotide binding

Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.

AHCY

GO:0030594

MF

neurotransmitter receptor activity

Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.

HTR2C, HTR7, HTR2B

GO:0030616

MF

transforming growth factor beta receptor, common-partner cytoplasmic mediator activity

A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription.

SMAD4

GO:0030617

MF

transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity

A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators.

SMAD7, SMAD6

GO:0030618

MF

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription.

SMAD9, SMAD3, SMAD2, SMAD1, SMAD5

GO:0030619

MF

U1 snRNA binding

Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA).

SNRPA, ISG20

GO:0030620

MF

U2 snRNA binding

Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA).

SNRPA1, TROVE2, SNRPB, SNRPD3, ISG20

GO:0030621

MF

U4 snRNA binding

Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA).

SNU13, SART3, PRPF31

GO:0030622

MF

U4atac snRNA binding

Interacting selectively and non-covalently with the U4atac small nuclear RNA (U4atac snRNA).

SNU13, PRPF31

GO:0030624

MF

U6atac snRNA binding

Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA).

SART3

GO:0030626

MF

U12 snRNA binding

Interacting selectively and non-covalently with the U12 small nuclear RNA (U12 snRNA).

RNPC3

GO:0030627

MF

pre-mRNA 5'-splice site binding

Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence.

SNRPC, PRPF39

GO:0030674

MF

protein binding, bridging

The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

FLRT2, CSTA, FGA, FGB, FGG, ANXA1, COL1A2, NEFH, COL11A1, COL11A2, DSP, BCL3, COL8A2, CBX5, CAV2, TIRAP, ARPC4, PSMC6, CRADD, ANK2, FKBP4, CAV1, COL14A1, ANK3, CUX1, FSCN1, GATAD2A, WWC1, TRIM22, RAD50, OPTN, TRIM6, ADAP2, FLRT3, FLRT1, FRMD4A, TJP2, DDX20, NUFIP1, C14orf1, AMFR, STUB1

GO:0030676

MF

Rac guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

FARP2, VAV1, TIAM1, PREX2, DOCK2, ARHGEF2, SPATA13, ALS2, ARHGEF4, VAV3, FARP1

GO:0030695

MF

GTPase regulator activity

Modulates the rate of GTP hydrolysis by a GTPase.

WASL, KRIT1, RGS12, RALGDS, PCP2, RIN2, GOPC, GPSM3

GO:0030729

MF

acetoacetate-CoA ligase activity

Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+).

AACS

GO:0030742

MF

GTP-dependent protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP.

RAB3B, CDC42, RAB5B, RAC1, RAB32, EEA1, RAPGEF6, RAB34, PARD6A

GO:0030760

MF

pyridine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine.

NNMT