GO:0015088

MF

copper uptake transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in).

SLC31A1

GO:0015091

MF

ferric iron transmembrane transporter activity

Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.

TF

GO:0015093

MF

ferrous iron transmembrane transporter activity

Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.

SLC11A2, SLC39A14, SLC40A1, SLC25A37

GO:0015094

MF

lead ion transmembrane transporter activity

Enables the transfer of lead (Pb) ions from one side of a membrane to the other.

SLC11A2

GO:0015095

MF

magnesium ion transmembrane transporter activity

Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.

ZDHHC17, NIPA2, SLC41A2, CNNM2, MRS2

GO:0015098

MF

molybdate ion transmembrane transporter activity

Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid.

MFSD5

GO:0015101

MF

organic cation transmembrane transporter activity

Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.

SLC22A1, SLC22A3, SLC7A8

GO:0015105

MF

arsenite transmembrane transporter activity

Enables the transfer of arsenite from one side of a membrane to the other.

ASNA1

GO:0015106

MF

bicarbonate transmembrane transporter activity

Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.

BEST1, CFTR, SLC26A2, SLC26A11, SLC26A1

GO:0015108

MF

chloride transmembrane transporter activity

Enables the transfer of chloride ions from one side of a membrane to the other.

CFTR, SLC26A1

GO:0015111

MF

iodide transmembrane transporter activity

Enables the transfer of iodide ions from one side of a membrane to the other.

SLC5A5

GO:0015114

MF

phosphate ion transmembrane transporter activity

Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other.

ANKH

GO:0015116

MF

sulfate transmembrane transporter activity

Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.

SLC26A2, SLC26A11, SLC26A1

GO:0015125

MF

bile acid transmembrane transporter activity

Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

SLCO2B1

GO:0015129

MF

lactate transmembrane transporter activity

Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.

SLC16A6, SLC16A3, SLC16A7, SLC16A12

GO:0015132

MF

prostaglandin transmembrane transporter activity

Enables the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.

SLCO2A1

GO:0015137

MF

citrate transmembrane transporter activity

Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other.

SLC25A1

GO:0015142

MF

tricarboxylic acid transmembrane transporter activity

Enables the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups.

SLC25A1

GO:0015152

MF

glucose-6-phosphate transmembrane transporter activity

Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6.

SLC37A4

GO:0015165

MF

pyrimidine nucleotide-sugar transmembrane transporter activity

Enables the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.

SLC35D2, SLC35D1

GO:0015166

MF

polyol transmembrane transporter activity

Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol.

AQP9, SLC5A11

GO:0015168

MF

glycerol transmembrane transporter activity

Enables the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

AQP2

GO:0015171

MF

amino acid transmembrane transporter activity

Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.

SLC6A6, SLC1A3, SLC1A2, SLC1A4, SLC1A6, SLC7A2, PEX3, SLC7A5, SLC1A5, SLC36A1, SLC38A9, SLC16A10, SLC38A5, SLC7A6, SLC38A1, SLC38A10, SLC7A8, SLC6A14

GO:0015172

MF

acidic amino acid transmembrane transporter activity

Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7.

SLC25A12, SLC25A13

GO:0015173

MF

aromatic amino acid transmembrane transporter activity

Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.

SLC16A10

GO:0015174

MF

basic amino acid transmembrane transporter activity

Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7.

SLC7A2, SLC7A7

GO:0015175

MF

neutral amino acid transmembrane transporter activity

Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7.

SLC3A2, SLC7A9, SLC7A5, SLC1A5, SLC38A1, SLC7A8

GO:0015179

MF

L-amino acid transmembrane transporter activity

Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids.

SLC7A2, SLC7A5, SLC7A6, SLC38A1, SLC7A8, SLC7A7

GO:0015180

MF

L-alanine transmembrane transporter activity

Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid.

SLC1A4, SLC36A1

GO:0015182

MF

L-asparagine transmembrane transporter activity

Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid.

SLC38A1

GO:0015183

MF

L-aspartate transmembrane transporter activity

Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.

SLC25A12, SLC1A6, SLC25A13

GO:0015184

MF

L-cystine transmembrane transporter activity

Enables the transfer of L-cystine from one side of a membrane to the other.

SLC1A4, SLC7A9

GO:0015186

MF

L-glutamine transmembrane transporter activity

Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid.

SLC1A4, SLC1A5, SLC38A1

GO:0015187

MF

glycine transmembrane transporter activity

Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid.

SLC36A1, SLC38A5

GO:0015193

MF

L-proline transmembrane transporter activity

Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.

SLC1A4, SLC36A1

GO:0015194

MF

L-serine transmembrane transporter activity

Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid.

SLC1A4, SERINC3, SLC1A5, SERINC5, SERINC2, SERINC1

GO:0015195

MF

L-threonine transmembrane transporter activity

Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid.

SLC1A4

GO:0015197

MF

peptide transporter activity

Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells.

DISP1

GO:0015198

MF

oligopeptide transporter activity

Enables the directed movement of oligopeptides into, out of or within a cell, or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.

SLC15A2

GO:0015204

MF

urea transmembrane transporter activity

Enables the directed movement of urea cross a membrane into, out of or within a cell, or between cells. Urea is the water soluble compound H2N-CO-NH2.

AQP9, SLC14A1, AQP3

GO:0015205

MF

nucleobase transmembrane transporter activity

Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other.

SLC23A2

GO:0015207

MF

adenine transmembrane transporter activity

Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other.

SLC25A5, SLC25A4

GO:0015217

MF

ADP transmembrane transporter activity

Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other.

SLC25A17

GO:0015218

MF

pyrimidine nucleotide transmembrane transporter activity

Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other.

SLC25A36

GO:0015220

MF

choline transmembrane transporter activity

Enables the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.

SLC44A2, SLC44A3, SLC44A5, SLC44A1

GO:0015222

MF

serotonin transmembrane transporter activity

Enables the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.

SLC18A2

GO:0015226

MF

carnitine transmembrane transporter activity

Enables the directed movement of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.

SLC22A5

GO:0015228

MF

coenzyme A transmembrane transporter activity

Enables the directed movement of coenzyme A across a membrane into, out of or within a cell, or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.

SLC25A17

GO:0015229

MF

L-ascorbic acid transporter activity

Enables the directed movement of L-ascorbate into, out of or within a cell, or between cells. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species.

SLC23A2

GO:0015230

MF

FAD transmembrane transporter activity

Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of or within a cell, or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form.

SLC25A17

GO:0015232

MF

heme transporter activity

Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells.

SLC46A1, ABCB6, FLVCR2

GO:0015234

MF

thiamine transmembrane transporter activity

Enables the transfer of thiamine from one side of the membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.

SLC19A2

GO:0015235

MF

cobalamin transporter activity

Enables the directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell.

CD320, LMBRD1

GO:0015238

MF

drug transmembrane transporter activity

Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

SLC22A5, EBP, SLC22A18, SLC47A1

GO:0015245

MF

fatty acid transporter activity

Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

SLC27A2, SLC27A4, SLC27A1, MFSD2A, SLC27A6

GO:0015248

MF

sterol transporter activity

Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

NPC1, OSBP, SCP2

GO:0015250

MF

water channel activity

Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

AQP9, AQP8, MIP, AQP2, AQP3

GO:0015252

MF

hydrogen ion channel activity

Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

NOX5

GO:0015254

MF

glycerol channel activity

Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

AQP9, AQP8, MIP, AQP2, AQP3

GO:0015265

MF

urea channel activity

Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

AQP9, SLC14A1

GO:0015266

MF

protein channel activity

Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel.

TIMM23, TIMM17B, TOMM40, MCL1, TOMM20, TIMM17A, TOMM22, TOMM7

GO:0015267

MF

channel activity

Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

BCL2, CHRNB1, MAL, BAX

GO:0015269

MF

calcium-activated potassium channel activity

Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.

KCNMA1, TMEM38B

GO:0015272

MF

ATP-activated inward rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.

KCNJ11

GO:0015275

MF

stretch-activated, cation-selective, calcium channel activity

Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching.

TRPV4

GO:0015276

MF

ligand-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

ANXA6, CHRNB1, CHRNA5, CHRNA7, NCALD, CALM2, DLG4, DLG1

GO:0015278

MF

calcium-release channel activity

Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.

ITPR3, ITPR1, RASA3, RYR3, TRPV1, RYR2

GO:0015279

MF

store-operated calcium channel activity

A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.

ZP3, TRPC1, TRPC3, ORAI2, ORAI3, STIM2, TRPC6

GO:0015280

MF

ligand-gated sodium channel activity

Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

SCNN1A, SCNN1G, SHROOM2, ASIC2

GO:0015288

MF

porin activity

Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.

AQP9, TOMM40, VDAC2, VDAC3

GO:0015291

MF

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport.

SLC25A16

GO:0015293

MF

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

SLC16A6, SLC16A3, SLC16A7, SLC22A5, SLC1A4, SLC25A3, SLC10A7, SLC1A5, MFSD4B, SLC16A12, SLC16A14, SLC16A9, MFSD2A, SLC5A11, SLC22A18, SLC46A2, SLC25A18, SLC24A3

GO:0015295

MF

solute:proton symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).

SLC33A1, SLC11A2

GO:0015297

MF

antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).

SLC25A16, CLCN3, CLCN4, CLCN5, CLCN6, CLCN7, SLC7A2, SLC7A9, SLC7A5, SLC7A6, SLC7A8, SLC7A7

GO:0015299

MF

solute:proton antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).

TMCO3

GO:0015301

MF

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

SLC4A2, SLC26A2, SLC4A8, SLC26A11, SLC26A1

GO:0015307

MF

drug:proton antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out).

SLC22A18, SLC47A1

GO:0015319

MF

sodium:inorganic phosphate symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in).

SLC20A2, SLC20A1

GO:0015320

MF

phosphate ion carrier activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate (cyt) + H+ (cyt) = phosphate (mitochondrion) + H+ (mitochondrion).

SLC25A3

GO:0015321

MF

sodium-dependent phosphate transmembrane transporter activity

Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions.

SLC20A2, SLC20A1

GO:0015327

MF

cystine:glutamate antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out).

SLC7A11

GO:0015333

MF

peptide:proton symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.

SLC15A2, SLC15A4

GO:0015347

MF

sodium-independent organic anion transmembrane transporter activity

Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner.

SLCO2B1, SLCO4C1, SLCO6A1, SLCO2A1, SLCO3A1

GO:0015349

MF

thyroid hormone transmembrane transporter activity

Enables the transfer of thyroid hormones from one side of the membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.

SLC16A10

GO:0015350

MF

methotrexate transporter activity

Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.

SLC19A1, SLC46A1

GO:0015385

MF

sodium:proton antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

SLC9A6, SLC9A2

GO:0015386

MF

potassium:proton antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).

SLC9A6, SLC9A2

GO:0015389

MF

pyrimidine- and adenine-specific:sodium symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in).

SLC28A3

GO:0015390

MF

purine-specific nucleoside:sodium symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in).

SLC28A3

GO:0015403

MF

thiamine uptake transmembrane transporter activity

Enables the transfer of thiamine from the outside of a cell to the inside across a membrane.

SLC19A2

GO:0015420

MF

cobalamin-transporting ATPase activity

Catalysis of the reaction: ATP + H2O + cob(III)alamin(out) = ADP + phosphate + cob(III)alamin(in). Cobalamin is also known as vitamin B12.

ABCC1

GO:0015439

MF

heme-transporting ATPase activity

Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out).

ABCB6

GO:0015450

MF

P-P-bond-hydrolysis-driven protein transmembrane transporter activity

Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.

TIMM23, TIMM17B, SEC61G, TOMM20, TIMM17A

GO:0015459

MF

potassium channel regulator activity

Modulates the activity of a potassium channel.

ADRB2, DPP6, ARPP19, YWHAE, DLG1, SGK3, NEDD4L, CHP1, KCNIP2

GO:0015464

MF

acetylcholine receptor activity

Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

CHRNB1, CHRNA5, CHRNA7

GO:0015467

MF

G-protein activated inward rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.

KCNJ12

GO:0015485

MF

cholesterol binding

Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

NPC1, ERLIN2, ABCA1, APOA1, APOE, APOA2, APOC3, PMP2, APOD, ANXA6, SCP2, TSPO, SOAT1, STAR, NPC2, CAV1, NR1H3, PTCH1, STARD3, APOA5, STARD4, OSBPL10, OSBPL8

GO:0015491

MF

cation:cation antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out).

SLC22A5

GO:0015501

MF

glutamate:sodium symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in).

SLC1A2

GO:0015562

MF

efflux transmembrane transporter activity

Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

ABCB6