| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0008310 | MF | single-stranded DNA 3'-5' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. |
ISG20 |
GO:0008312 | MF | 7S RNA binding | Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). |
SRP72, SRP14, SRP9, SRP54, EXOSC2 |
GO:0008320 | MF | protein transmembrane transporter activity | Enables the transfer of a protein from one side of a membrane to the other. |
TOMM40, AZGP1, NUTF2, TOMM22, TOMM7 |
GO:0008321 | MF | Ral guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
RALGPS1, RGL1 |
GO:0008324 | MF | cation transmembrane transporter activity | Enables the transfer of cation from one side of the membrane to the other. |
SLC30A9, SLC41A3 |
GO:0008327 | MF | methyl-CpG binding | Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. |
MBD3, DNMT1, ERH, ZBTB33, ZBTB38, UHRF1, PRMT1, ZBTB4, LRWD1, ZBTB21 |
GO:0008329 | MF | signaling pattern recognition receptor activity | Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity. |
TLR2, COLEC12, CLEC7A, DMBT1 |
GO:0008330 | MF | protein tyrosine/threonine phosphatase activity | Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
DUSP1, DUSP2 |
GO:0008331 | MF | high voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. |
CACNB3, CACNA1C, CACNA1E |
GO:0008332 | MF | low voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. |
CACNA1G |
GO:0008349 | MF | MAP kinase kinase kinase kinase activity | Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. |
MAP4K3, MAP4K5 |
GO:0008353 | MF | RNA polymerase II carboxy-terminal domain kinase activity | Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. |
CDK1, ERCC2, MAPK1, GTF2H1, CDK8, CDK7, GTF2H2, CDK13, GTF2H4, CDK12 |
GO:0008373 | MF | sialyltransferase activity | Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. |
ST6GAL1, ST8SIA6, ST6GALNAC5, ST6GALNAC4, ST6GALNAC2 |
GO:0008374 | MF | O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. |
LCLAT1, PIGW |
GO:0008375 | MF | acetylglucosaminyltransferase activity | Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. |
OGT, LARGE, HEXA, EXT1, POMGNT2, EXT2, XYLT2 |
GO:0008376 | MF | acetylgalactosaminyltransferase activity | Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. |
CSGALNACT1 |
GO:0008378 | MF | galactosyltransferase activity | Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
B4GALT5, B4GALT4, B4GALT1, B3GNT9, B4GALT6 |
GO:0008379 | MF | thioredoxin peroxidase activity | Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. |
PRDX2, PRDX1, PRDX4 |
GO:0008381 | MF | mechanically-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress. |
PIEZO1 |
GO:0008386 | MF | cholesterol monooxygenase (side-chain-cleaving) activity | Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. |
CYP11A1 |
GO:0008389 | MF | coumarin 7-hydroxylase activity | Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. |
CYP2A6 |
GO:0008392 | MF | arachidonic acid epoxygenase activity | Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. |
CYP2E1, CYP2D6, CYP2A6, CYP2C9, CYP2B6 |
GO:0008395 | MF | steroid hydroxylase activity | Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. |
CH25H, CYP2E1, CYP3A4, CYP21A2, CYP2D6, CYP2A6, CYP19A1, CYP2C9, CYP11B2, CYP2B6, CYP3A7, CYP2R1, CYP2U1, CYP2W1 |
GO:0008397 | MF | sterol 12-alpha-hydroxylase activity | Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O. |
CYP8B1 |
GO:0008398 | MF | sterol 14-demethylase activity | Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O. |
CYP51A1 |
GO:0008401 | MF | retinoic acid 4-hydroxylase activity | Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. |
CYP26A1, CYP26B1 |
GO:0008408 | MF | 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
RAD1, REV3L, POLA1, MRE11A, POLG, POLE, RAD9B, RAD50, RAD9A, REXO2 |
GO:0008409 | MF | 5'-3' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. |
DXO, FEN1, DCLRE1C, EXO1, EXOG, FAN1 |
GO:0008413 | MF | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. |
NUDT1, NUDT15 |
GO:0008417 | MF | fucosyltransferase activity | Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
FUT1, FUT4, FUT2 |
GO:0008420 | MF | CTD phosphatase activity | Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate. |
CTDSP2, CTDSP1, SSU72 |
GO:0008422 | MF | beta-glucosidase activity | Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. |
LCT, GBA2, KL |
GO:0008424 | MF | glycoprotein 6-alpha-L-fucosyltransferase activity | Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+). |
FUT8 |
GO:0008425 | MF | 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity | Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. |
COQ3 |
GO:0008426 | MF | protein kinase C inhibitor activity | Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. |
HSPB1, SFN |
GO:0008427 | MF | calcium-dependent protein kinase inhibitor activity | Stops, prevents or reduces the activity of a calcium-dependent protein kinase. |
CAMK2N1, CIB1 |
GO:0008428 | MF | ribonuclease inhibitor activity | Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA. |
RNH1 |
GO:0008429 | MF | phosphatidylethanolamine binding | Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
ESYT2, PEBP1, ANXA11, MFGE8, MAP1LC3A, PEMT |
GO:0008430 | MF | selenium binding | Interacting selectively and non-covalently with selenium (Se). |
SELENOF, GPX3, SEPP1, SELT, SELENBP1, DIO2 |
GO:0008431 | MF | vitamin E binding | Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. |
SEC14L2 |
GO:0008432 | MF | JUN kinase binding | Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. |
SPAG9, GSTP1, PTK2, MAPK8IP3, MAPK8IP1 |
GO:0008434 | MF | calcitriol receptor activity | Combining with calcitriol, the hormonally active form of vitamin D3, and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
VDR |
GO:0008437 | MF | thyrotropin-releasing hormone activity | The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. |
TRH |
GO:0008440 | MF | inositol-1,4,5-trisphosphate 3-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). |
ITPKA, CALM2, IP6K2 |
GO:0008442 | MF | 3-hydroxyisobutyrate dehydrogenase activity | Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. |
HIBADH |
GO:0008444 | MF | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity | Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+). |
PGS1 |
GO:0008446 | MF | GDP-mannose 4,6-dehydratase activity | Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O. |
GMDS |
GO:0008449 | MF | N-acetylglucosamine-6-sulfatase activity | Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. |
GNS, SULF2, SULF1 |
GO:0008453 | MF | alanine-glyoxylate transaminase activity | Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. |
AGXT |
GO:0008454 | MF | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R. |
MGAT4A, MGAT4B |
GO:0008455 | MF | alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R. |
MGAT2 |
GO:0008457 | MF | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide. |
B3GNT5 |
GO:0008458 | MF | carnitine O-octanoyltransferase activity | Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA. |
CROT |
GO:0008459 | MF | chondroitin 6-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. |
CHST3, CHST7 |
GO:0008460 | MF | dTDP-glucose 4,6-dehydratase activity | Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O. |
TGDS |
GO:0008465 | MF | glycerate dehydrogenase activity | Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+. |
GRHPR |
GO:0008466 | MF | glycogenin glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. |
GYG2 |
GO:0008467 | MF | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. |
HS3ST1, HS3ST3B1 |
GO:0008469 | MF | histone-arginine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine. |
PRMT3, CARM1, PRMT6 |
GO:0008474 | MF | palmitoyl-(protein) hydrolase activity | Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. |
LYPLA1, LYPLA2, PPT1, PPT2 |
GO:0008475 | MF | procollagen-lysine 5-dioxygenase activity | Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. |
PLOD2, PLOD1 |
GO:0008476 | MF | protein-tyrosine sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate. |
TPST1, TPST2 |
GO:0008478 | MF | pyridoxal kinase activity | Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. |
PDXK |
GO:0008479 | MF | queuine tRNA-ribosyltransferase activity | Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. |
PDC, PDCL, PDCL3 |
GO:0008480 | MF | sarcosine dehydrogenase activity | Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein. |
SARDH |
GO:0008481 | MF | sphinganine kinase activity | Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. |
SPHK1 |
GO:0008482 | MF | sulfite oxidase activity | Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate. |
SUOX |
GO:0008483 | MF | transaminase activity | Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. |
AGXT, PHYKPL |
GO:0008484 | MF | sulfuric ester hydrolase activity | Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. |
STS, ARSA, GNS, GALNS, SGSH |
GO:0008486 | MF | diphosphoinositol-polyphosphate diphosphatase activity | Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. |
NUDT3, NUDT10, NUDT11 |
GO:0008488 | MF | gamma-glutamyl carboxylase activity | Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide. |
GGCX |
GO:0008494 | MF | translation activator activity | Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. |
LARP1, RPS27L, PAIP1 |
GO:0008496 | MF | mannan endo-1,6-alpha-mannosidase activity | Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans. |
MAN2B2 |
GO:0008499 | MF | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. |
B3GALT2, B3GALT4, B3GNT7, B3GNT5, B3GNT2 |
GO:0008502 | MF | melatonin receptor activity | Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. |
MTNR1A, MTNR1B |
GO:0008503 | MF | benzodiazepine receptor activity | Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. |
TSPO |
GO:0008504 | MF | monoamine transmembrane transporter activity | Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other. |
SLC18A2 |
GO:0008506 | MF | sucrose:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in). |
SLC45A2 |
GO:0008507 | MF | sodium:iodide symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in). |
SLC5A5 |
GO:0008509 | MF | anion transmembrane transporter activity | Enables the transfer of a negatively charged ion from one side of a membrane to the other. |
ABCA1, SLC4A2, SLC4A8, SLC26A11 |
GO:0008510 | MF | sodium:bicarbonate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). |
SLC4A4 |
GO:0008511 | MF | sodium:potassium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in). |
SLC12A2 |
GO:0008513 | MF | secondary active organic cation transmembrane transporter activity | Catalysis of the transfer of organic cations from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. |
SLC22A1 |
GO:0008514 | MF | organic anion transmembrane transporter activity | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. |
SLC22A23, ABCC5, SLCO2B1 |
GO:0008517 | MF | folic acid transporter activity | Enables the directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
SLC19A2, FOLR1, SLC19A1, SLC46A1 |
GO:0008518 | MF | reduced folate carrier activity | Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
SLC19A1 |
GO:0008519 | MF | ammonium transmembrane transporter activity | Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. |
SLC12A2, RHBG |
GO:0008520 | MF | L-ascorbate:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in). |
SLC23A2 |
GO:0008521 | MF | acetyl-CoA transporter activity | Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
SLC33A1 |
GO:0008523 | MF | sodium-dependent multivitamin transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate. |
SLC23A2 |
GO:0008525 | MF | phosphatidylcholine transporter activity | Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
PITPNA, PCTP |
GO:0008526 | MF | phosphatidylinositol transporter activity | Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
PITPNA, PITPNC1 |
GO:0008528 | MF | G-protein coupled peptide receptor activity | Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
GPR37, NPR3, LHCGR, FSHR |
GO:0008531 | MF | riboflavin kinase activity | Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+). |
RFK |
GO:0008532 | MF | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. |
B4GAT1, B3GNT7, B3GNT2 |
GO:0008534 | MF | oxidized purine nucleobase lesion DNA N-glycosylase activity | Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. |
NTHL1 |
GO:0008536 | MF | Ran GTPase binding | Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. |
IPO5, TNPO2, XPO1, BIRC5, RANBP1, RANGAP1, RANBP2, CSE1L, NUTF2, KPNB1, IPO4, IPO9, RANBP9, XPO4, RANGRF, NXT1, NUP50 |
GO:0008553 | MF | hydrogen-exporting ATPase activity, phosphorylative mechanism | Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle. |
ATP6V1G1, ATP6V1G2, ATP6V1C1, ATP6V0D1, ATP6V1C2 |
GO:0008555 | MF | chloride-transporting ATPase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in). |
PCYOX1 |
GO:0008559 | MF | xenobiotic-transporting ATPase activity | Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). |
ABCA8 |