| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0005545 | MF | 1-phosphatidylinositol binding | Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
SYT1, PICALM, EEA1, ZFYVE16, SCARB1, PLEKHA4, PLEKHA5, ZFYVE1, SNX9 |
GO:0005546 | MF | phosphatidylinositol-4,5-bisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
MYO1G, KRIT1, TULP3, ANXA2, PFN1, ALOX15, SYT1, ACTN2, TIRAP, FCHO2, TWF1, FRMPD4, LDLRAP1, TWF2, COMMD1, STXBP6, PARD3, SNX21, SNX18, MAPKAP1, SYTL2, ADAP2, PLCB1, EXOC1, MARK1, ASAP1 |
GO:0005547 | MF | phosphatidylinositol-3,4,5-trisphosphate binding | Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. |
MYO1G, OGT, CYTH3, ADAP1, NPM1, AKT1, IQGAP1, IQGAP2, ZFYVE16, COMMD1, PARD3, ARAP3, ARAP2, GBF1, ARAP1, MAPKAP1, RACGAP1, ZFYVE1, MYO10, ADAP2, ASAP1 |
GO:0005548 | MF | phospholipid transporter activity | Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. |
ABCA1, APOA1, MFSD2A, OSBPL8 |
GO:0005549 | MF | odorant binding | Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell. |
OR5A2, OR5L2, OR14C36 |
GO:0008009 | MF | chemokine activity | The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
CXCL14, PPBP, PF4, CXCL1, CXCL8, CCL3, CCL4, CCL2, CCL5, CXCL2, CXCL5, CXCL12, CCL20, CCL8, CXCL6, CXCL16, CKLF |
GO:0008013 | MF | beta-catenin binding | Interacting selectively and non-covalently with the beta subunit of the catenin complex. |
TAX1BP3, SMAD7, AXIN1, KLF4, FOXO3, PARK2, TBL1X, ESR1, GLI3, AR, CDH2, APC, CDH5, CTNNA1, RORA, NR4A2, SOX9, NUMB, PSEN1, GSK3B, SKP1, CXADR, SMAD3, FOXO4, EP300, FOXO1, PTPRJ, SHROOM2, KANK1, PTPRK, CARM1, DLG5, LZIC, MED12, DACT3, TBL1XR1, SOX17, CHD8, TCF7L1, TCF7L2, DACT1, ASH2L, HDAC6, SUFU, BTRC |
GO:0008017 | MF | microtubule binding | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
EML1, KRIT1, DYNC1I1, MID1, BIRC5, BCL2L11, PRC1, ZNF207, KIF1C, KIF5C, OPA1, KIF1B, PEX14, TPPP, KIF20A, KIF4A, VAPB, EML2, CRYAB, PRNP, GAPDH, S100A8, S100A9, MAPT, MAP2, NEFH, TPT1, EZR, APC, CLIP1, SNCA, LRPPRC, MAP1B, KIF11, PLK1, GABARAPL2, RAB11A, RAE1, MAP1A, CENPE, KIF23, FMR1, GOLGA2, TIAM1, KIF22, CHD4, FAM175B, KIF14, CNN3, MAPRE2, DPYSL2, CCDC88A, CAMSAP1, SAXO2, MAST2, KLC3, PSRC1, HOOK3, GAS2L3, CEP57, KIF18B, KIF18A, MDM1, SKA2, NDRG1, FGF13, ARHGEF2, JAKMIP2, SKA1, MARK4, KIF20B, CHP1, KATNB1, KIFC1, KATNAL1, NUSAP1, NDEL1, MAP1LC3B, RACGAP1, MAP1LC3A, FAM83D, REEP1, TRPV4, EML4, KIF13B, KIF15, SYBU, NDE1, CRIPT, VAPA, STARD9, UXT, HDAC6, SPAST, SUN2, MACF1, MAPRE3, LZTS1, SBDS, HDGFRP3, KIF3A |
GO:0008020 | MF | G-protein coupled photoreceptor activity | Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
OPN1SW, ELOVL4, OPN3 |
GO:0008022 | MF | protein C-terminus binding | Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
MIF4GD, MYO1C, FOXN3, KPNA3, SDCBP, PEX12, KCNK3, TAX1BP3, DAPK3, JAK2, TBL1X, VPS4B, YEATS4, EML2, BCL10, ERBB2, ATP1B1, ERCC1, VIM, TOP2A, XRCC5, TCF4, ATP2A2, ERCC2, SDC1, ATF4, NCF2, SYT1, FBLN1, CTGF, CORO1A, YWHAB, STIP1, CTNNB1, PHB, PPP1CC, COIL, ID1, OPRL1, CSK, MSH2, MKI67, YAP1, CENPF, MRE11A, CDK7, BCAM, BRCA2, ATXN1, SYNJ2BP, PPP2CB, DLG4, DAB2, HSPG2, MAP2K1, DST, ZBTB16, RAD51, TJP1, EP300, SREBF2, CDC20, DLG1, ITGB3BP, XRCC4, NPAT, KCNJ11, MDC1, MAPRE1, CEP135, NIPBL, PXK, SIAH1, CEP120, TOPBP1, ERCC4, MED12, OPTN, HIC2, MAGI1, PHB2, CIB1, CITED1, SDCBP2, GOPC, VTA1, MID1IP1, IFT46, HOMER3, RBFOX1, SAE1, PLEKHB1, AGO2, HPCAL4, PRRC2C |
GO:0008026 | MF | ATP-dependent helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
BLM, ERCC6L2, TTF2 |
GO:0008028 | MF | monocarboxylic acid transmembrane transporter activity | Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. |
SLC16A6, SLC16A3, SLC16A7, BSG, SLC16A14, SLC16A9 |
GO:0008035 | MF | high-density lipoprotein particle binding | Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. |
APOA1, APOA2, CD36, SCARB1, APOL2 |
GO:0008046 | MF | axon guidance receptor activity | Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. |
EPHB2, EPHB1, ROBO2 |
GO:0008047 | MF | enzyme activator activity | Binds to and increases the activity of an enzyme. |
OGT, CFLAR, ASAP2, PPP1R12B, PRKRA, PSAP, CXCL1, TRIM23, MMP15, MMP16, CASP9, PRKCD, TAB1, HSPB2, PITRM1, APOA5, RICTOR, MGST2, RAB3GAP2, SAE1, DBF4, GTF3C4, MMP24 |
GO:0008048 | MF | calcium sensitive guanylate cyclase activator activity | Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration. |
GUCA1C, GUCA1B |
GO:0008061 | MF | chitin binding | Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. |
CHI3L1, CTBS, CHIT1 |
GO:0008066 | MF | glutamate receptor activity | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
GRM8, GRM6, GRM3 |
GO:0008073 | MF | ornithine decarboxylase inhibitor activity | The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase. |
OAZ2, OAZ1 |
GO:0008080 | MF | N-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. |
ESCO2, NAT14, NAT9 |
GO:0008081 | MF | phosphoric diester hydrolase activity | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
PLCXD2, PLCXD3 |
GO:0008083 | MF | growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
MSTN, EREG, GDF9, FGF18, DKK1, CSPG5, GDF11, BMP10, FGF19, BMP15, F2, AGT, TIMP1, PDGFB, TGFA, TGFB1, NGF, GH1, IGF2, PPBP, AMH, PDGFA, IGF1, INHA, IL6, GPI, INHBA, FGF2, CXCL1, INHBB, BMP2, BMP4, BMP3, TDGF1, BMP1, HGF, LIF, AREG, VEGFA, TYMP, OGN, IL11, KITLG, MDK, FGF7, BMP6, IL10, BDNF, GRN, CTGF, IL12A, FGF9, BMP8B, BTC, THBS4, LEP, GDF5, CXCL12, PGF, VEGFB, VEGFC, HDGF, INHBC, GFER, FGF12, TGFB2, JAG1, NDP, NRG1, EFEMP1, RABEP1, IL34, BMP8A, FGF13, FGF11, FGF14, HBEGF, GDF15, PDGFD, CD320, PDGFC, CLCF1, OSGIN1, NENF, HDGFRP3 |
GO:0008092 | MF | cytoskeletal protein binding | Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
FRMD3, TOR1A, LDB3, NEBL, FARP2, ALDOA, FABP3, ANXA2, TPM1, ALDOC, B4GALT1, DES, PTPN4, CORO1A, ACTN2, CDK5, ANK3, DLG1, PKD2, FLNC, ABI1, DLG5, MYLIP, SORBS1, PACSIN1, EPB41L4B, CAPN10, EPB41L4A, LIN7C, RPH3AL, FARP1 |
GO:0008093 | MF | cytoskeletal adaptor activity | The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way. |
SDCBP, OBSL1, SORBS2, ANK2, ANK3, BICD1, ABI2, BAIAP2L1 |
GO:0008094 | MF | DNA-dependent ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction. |
RAD51C, RAD51D, TOP2A, ERCC2, SMARCA1, GTF2H1, CDK7, SMARCA2, SMARCA4, RBBP4, GTF2H2, GTF2H4, DHX36, CHD8, TTF2 |
GO:0008097 | MF | 5S rRNA binding | Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
EEF2, RPL5 |
GO:0008107 | MF | galactoside 2-alpha-L-fucosyltransferase activity | Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. |
FUT1, FUT2 |
GO:0008108 | MF | UDP-glucose:hexose-1-phosphate uridylyltransferase activity | Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. |
GALT |
GO:0008109 | MF | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. |
GCNT2 |
GO:0008112 | MF | nicotinamide N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. |
NNMT |
GO:0008113 | MF | peptide-methionine (S)-S-oxide reductase activity | Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. |
TXN2 |
GO:0008115 | MF | sarcosine oxidase activity | Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2). |
PIPOX |
GO:0008116 | MF | prostaglandin-I synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2). |
PTGIS |
GO:0008118 | MF | N-acetyllactosaminide alpha-2,3-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein. |
ST3GAL3 |
GO:0008119 | MF | thiopurine S-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. |
TPMT |
GO:0008120 | MF | ceramide glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. |
UGCG |
GO:0008121 | MF | ubiquinol-cytochrome-c reductase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. |
UQCRHL, UQCRQ, UQCR11, UQCRH, UQCRB, UQCRC1, UQCRFS1, UQCR10 |
GO:0008131 | MF | primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
AOC2, VCAM1, MAOA, MAOB, AOC3 |
GO:0008134 | MF | transcription factor binding | Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. |
MED19, AIP, APBB1, WWP2, DDX3X, HDAC3, PER1, RBFOX2, KDM1A, SORBS3, CCNT1, TBL1X, NBN, MED6, CREG1, PSMD10, UBXN7, APBB3, BCL10, FOS, MYC, ESR1, TP53, JUN, RB1, HMGB1, PARP1, TRAPPC2, AR, BCL2, THRA, ETS1, TCF3, HMGA1, JUNB, JUND, ATF7, CEBPB, NFKB1, BCL3, FLNA, GPX3, HMGB2, ARNT, PIK3R1, MAPK1, RBL1, CTNNB1, GTF2F1, RORA, DDIT3, AHR, PPARG, ZEB1, PBX2, STAT3, ID1, HTT, GATA4, MAPK9, CENPF, AGTR2, SMARCA4, NR0B1, GTF2A1, GTF2A2, HMGA2, FOSB, CEBPG, HDAC4, SOX8, LMO4, YWHAZ, UBE2I, PRKDC, SMAD3, FOXO4, GTF2B, PURA, E2F1, DR1, ID3, HHEX, PPARD, RELA, TLE1, C1QBP, PPARA, PPID, EP300, FOXC1, STK4, NFATC2, HDAC1, TDG, ENPP2, NFYC, HNRNPD, TFDP1, E2F2, HES1, NFATC4, NR0B2, NCOA2, TWIST1, SMAD2, TAF12, CRY1, HIF1A, IFI16, SMARCD3, KCTD1, CXXC5, PPARGC1B, SIRT2, PPP1R13L, ZFPM2, KAT6B, TRIB2, HDAC2, CREBBP, KAT6A, KAT2B, APBB2, GATA6, ARHGEF2, HES6, PURB, TRIB1, TCF12, PITX2, MDFI, EPAS1, SOST, MYBBP1A, HDAC8, TRIM6, NIF3L1, NUCKS1, SOX17, TAF9B, HES4, PARD6A, BRD7, HEYL, TCF7L2, RNF19A, RCOR3, NLK, PPARGC1A, MLX, HDAC9, SUFU, HDAC5, DRG1, CSDC2, HES2, PAXBP1, HEY1, MAFB, NCOR2, CHCHD2 |
GO:0008135 | MF | translation factor activity, RNA binding | Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome. |
EIF4G3, EIF4E2, GATB, EEF1D, EIF2S3, EIF1, EIF1AX, EIF5, EIF4A1, EEF1A2, GTF2H2, CPEB4, CPEB2, CPEB3, ABCF1, GCN1, MTIF3, EIF2B3 |
GO:0008137 | MF | NADH dehydrogenase (ubiquinone) activity | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. |
NDUFS8, NDUFA4, NDUFAB1, NDUFA1, NDUFS4, NDUFA2, NDUFS2, NDUFS6, NDUFB6, NDUFB4, NDUFB8, NDUFA7, NDUFA10, NDUFB10, NDUFB7, NDUFV2, NDUFS1, NDUFV3, NDUFA5, NDUFAF2, NMES1, NDUFA13 |
GO:0008138 | MF | protein tyrosine/serine/threonine phosphatase activity | Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
PTPDC1, CDC14B, DUSP11, SBF1, DUSP3, TPTE, PTEN, MTMR2, CDKN3, DUSP5, DUSP6, DUSP7, SSH2, DUSP18, SSH3, PTPMT1, PTP4A1, DUSP9, DUSP26, DUSP23, DUSP22, DUSP13, CDC14A |
GO:0008139 | MF | nuclear localization sequence binding | Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
IPO5, KPNA3, KPNA4, TNPO2, KPNA5, RANBP6, NUP153, KPNA2, KPNA1, KPNB1, IPO4, NUP58, TNPO3 |
GO:0008140 | MF | cAMP response element binding protein binding | Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein). |
DAPK3, DDIT3, SIK1, CREM, CRTC3 |
GO:0008142 | MF | oxysterol binding | Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol. |
OSBP, GPR183, RORA |
GO:0008143 | MF | poly(A) binding | Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. |
DDX3X, SYNCRIP, TIA1, KHDRBS1, ZC3H14, RBPMS, PABPC3 |
GO:0008144 | MF | drug binding | Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. |
DHFR, PNP, ALB, MT2A, TYMS, ATP1B1, CHRM2, HSP90AB1, GSTP1, CYP2D6, TOP2A, CYP2C9, ACE, DRD2, FOLR1, CHRM3, CNR1, NME2, MT3, HMGB2, DCK, HTR2C, CHKA, PPARG, HTR2B, NAMPT, ATP5O, GLRB, FASN, ATP1A2, PGGT1B, SRP54, HMGCS1, DHODH, PPARD, PPARA, PPP3CA, PDE4D, FSCN1, SFRP1, P2RX4, SIGMAR1 |
GO:0008146 | MF | sulfotransferase activity | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
HS3ST1, HS6ST1, SULT1A3, SULT2A1, CHST3, DSEL, CHST4, CHST5, CHST2 |
GO:0008147 | MF | structural constituent of bone | The action of a molecule that contributes to the structural integrity of bone. |
BGLAP, MGP |
GO:0008157 | MF | protein phosphatase 1 binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 1. |
PPP1R15A, STAU1, PPP1CC, PPP1CA, PHACTR4, LILRB1, SH3RF2, CDC5L, AKAP11 |
GO:0008158 | MF | hedgehog receptor activity | Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity. |
PTCH1, B9D1 |
GO:0008160 | MF | protein tyrosine phosphatase activator activity | Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein. |
IGFBP3, PPP2R4 |
GO:0008168 | MF | methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
PRMT3, COMT, PRDM15, NDUFAF5, TYW3, METTL23, PRMT1, METTL17, METTL8, PRDM10, METTL5, FAM86C1 |
GO:0008170 | MF | N-methyltransferase activity | Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. |
PRMT1 |
GO:0008171 | MF | O-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. |
COMT, BCDIN3D, COQ3 |
GO:0008173 | MF | RNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
BCDIN3D |
GO:0008175 | MF | tRNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. |
TRMT13 |
GO:0008177 | MF | succinate dehydrogenase (ubiquinone) activity | Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol. |
SDHB, SDHA |
GO:0008179 | MF | adenylate cyclase binding | Interacting selectively and non-covalently with the enzyme adenylate cyclase. |
ADRB2, ADCYAP1R1, CALM2, AKAP6 |
GO:0008184 | MF | glycogen phosphorylase activity | Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. |
PYGB, PYGM |
GO:0008186 | MF | RNA-dependent ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. |
DDX17, YTHDC2 |
GO:0008187 | MF | poly-pyrimidine tract binding | Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. |
PTBP1 |
GO:0008188 | MF | neuropeptide receptor activity | Combining with a neuropeptide to initiate a change in cell activity. |
NPBWR1, KISS1R |
GO:0008190 | MF | eukaryotic initiation factor 4E binding | Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
DDX3X, OTX2, HHEX, EIF4EBP1, EIF4EBP2, LARP1, ANGEL1 |
GO:0008191 | MF | metalloendopeptidase inhibitor activity | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
RECK, TIMP1, NGF, TIMP2, TIMP3, COL4A3, BST2, SPOCK2, SPOCK3, LXN, FETUB |
GO:0008194 | MF | UDP-glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. |
PIGA |
GO:0008195 | MF | phosphatidate phosphatase activity | Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. |
PLPP1, PLPP3, LPIN1, PLPPR4, PLPP5, PLPPR2 |
GO:0008198 | MF | ferrous iron binding | Interacting selectively and non-covalently with ferrous iron, Fe(II). |
TF, TH, SNCA, ALKBH1, FXN, CDO1, HEPH, ISCA1, FTO |
GO:0008199 | MF | ferric iron binding | Interacting selectively and non-covalently with ferric iron, Fe(III). |
TF, FTL, FTH1, TH, FXN, MIOX |
GO:0008200 | MF | ion channel inhibitor activity | Stops, prevents, or reduces the activity of an ion channel. |
ENSA, RACK1 |
GO:0008201 | MF | heparin binding | Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
CYR61, PDCD5, NRP1, MSTN, ZNF207, NRP2, WISP2, ECM2, SLIT2, WISP1, SERPINC1, KNG1, APOE, APOH, FN1, PF4, ANG, VTN, APOB, APP, SERPINA5, MPO, CLEC3B, LPL, SERPINE2, THBS1, SOD3, CFH, FGF2, SAA1, PTPRF, FGFR1, BMP4, CCL2, PRG2, SELL, VEGFA, OGN, COL5A1, MDK, FGF7, FGFR2, TNXB, ANOS1, COL5A3, PCSK6, CTGF, LRPAP1, FGF9, RPL22, THBS4, FBN1, PLA2G5, RPL29, COMP, PGF, VEGFB, HDGF, CCL8, CXCL6, TGFBR3, APLP2, FMOD, FSTL1, PTCH1, GPNMB, POSTN, PCOLCE, HSD17B12, COL13A1, APOA5, CCDC80, NAV2, SFRP1, NDNF, ADAMTS15, LIPH, HBEGF, EPYC, SOST, LXN, RSPO3, CRISPLD2, SMOC2, GREM2, ADAMTS1, PCOLCE2, ADAMTS5, ADAMTS8, LIPG, ADGRG1 |
GO:0008233 | MF | peptidase activity | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. |
MASP2, TPP1, DHH, CAPN15, CTSB, CTSH, FURIN, BMP1, UCHL3, CAPN3, PSMB5, CASP9, FGL2, CASP8, SPCS2, CLPP, DESI1, LONP2, MPND, HM13, APH1B, BAP1, PCSK5, USP25, MYRF |
GO:0008234 | MF | cysteine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
CAPN15, CTSL, CTSB, CTSH, CAPN3, CTSK, CTSC, CASP6, BLMH, ESPL1, CASP8, OTUD7B, PIGK, PGPEP1, CTSZ |
GO:0008235 | MF | metalloexopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
LAP3, METAP2, NUDT16, ERAP1 |
GO:0008236 | MF | serine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
TPP1, KLK10, C1R, PLG, KLK3, PRSS1, DPP4, PRSS3, DPP6, PREP, PRSS12, HTRA3, CTRB2, HTRA1, SEC11C |
GO:0008237 | MF | metallopeptidase activity | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
ADAM10, ADAM12, ADAM23, STAMBP, ECEL1, MMP2, MME, ACE, BMP1, MMP9, BRCC3, ADAM8, ADAM17, PAPPA, ADAM9, ERAP2, ERMP1, AOPEP, STAMBPL1, YME1L1, XPNPEP3, ADAMTS9, ADAMTS1, LNPEP, ADAM21, ADAMTS7, ADAMTS6, ADAMTS5, ADAMTS8 |
GO:0008238 | MF | exopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. |
MME, ACE, GGH |
GO:0008239 | MF | dipeptidyl-peptidase activity | Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. |
DPP4 |
GO:0008240 | MF | tripeptidyl-peptidase activity | Catalysis of the release of an N-terminal tripeptide from a polypeptide. |
TPP1, ACE, TPP2 |
GO:0008241 | MF | peptidyl-dipeptidase activity | Catalysis of the release of C-terminal dipeptides from a polypeptide chain. |
ACE |
GO:0008242 | MF | omega peptidase activity | Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). |
UCHL1, GGH |
GO:0008252 | MF | nucleotidase activity | Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. |
NT5C |
GO:0008253 | MF | 5'-nucleotidase activity | Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. |
ACPP, NT5E, NT5DC3, NT5C, NT5DC2 |
GO:0008260 | MF | 3-oxoacid CoA-transferase activity | Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA. |
OXCT1 |
GO:0008263 | MF | pyrimidine-specific mismatch base pair DNA N-glycosylase activity | Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site. |
MBD4, TDG |
GO:0008265 | MF | Mo-molybdopterin cofactor sulfurase activity | Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase. |
MOCOS |
GO:0008266 | MF | poly(U) RNA binding | Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule. |
HNRNPC, HNRNPH1, ATXN1, FMR1, KHDRBS1, PNPT1, MSI2 |
GO:0008267 | MF | poly-glutamine tract binding | Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein. |
RERE |
GO:0008269 | MF | JAK pathway signal transduction adaptor activity | The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way. |
SOCS2 |
GO:0008270 | MF | zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
MEX3A, ZSWIM8, ERI2, NEURL1B, ZBBX, PDLIM1, RNF103, NR5A2, ZNF593, PEX12, TRIM38, MAN2B1, PDXK, CCS, ABLIM1, MDM4, ZNF185, MID1, SIAH2, TGFB1I1, DHH, KLF4, CA12, ZNF207, NRDC, PARK2, LPXN, TRIM13, LDB3, ZPR1, ZNF253, PMPCB, MYCBP2, TCEA3, CAPN15, KLF7, RNF8, ZFAND5, MICAL2, SEC24D, ABLIM3, KDM4B, TRIM37, UBR5, ZFPL1, ZNF205, ZRANB2, TNKS, PAPLN, POLR1A, CNOT4, ZMYM6, CRYZL1, WHSC1, ADH1B, ADA, CA2, KNG1, CD4, MT2A, ESR1, MMP1, NR3C1, TK1, S100B, TP53, MT1E, MT1F, S100A8, PRKCB, PGR, S100A9, S100A6, CA3, GALT, MMP2, SOD3, MME, SNRPC, MMP10, PARP1, GLI2, AR, NR2F1, THRA, VDR, ESRRA, DMD, SKI, ACE, BMP1, MT1G, ALAD, CPM, IDE, MMP9, CPN1, RAG1, CPE, ZNF22, ZNF24, PRKCA, EGR1, PAM, WT1, NR1D1, PTMS, CSRP1, TNFAIP3, ENPP1, UQCRC2, NR4A1, CA4, MMP8, MMP11, NR2F2, YY1, MT3, LMO2, DNMT1, CAD, CALR, RXRB, KDM5A, CLIP1, S100A7, UQCRC1, DCTD, CA8, RORA, FUS, ZNF93, TRIM23, POLR2I, PPARG, ZEB1, SNCA, BRCA1, ADH7, RPS27, MATR3, NR4A2, GATA4, LIMS1, MAN2A2, NUP153, RANBP2, MMP14, LHX2, PDLIM4, RNF144A, MMP15, MMP16, ZNF84, RBM5, PGGT1B, RABGGTB, LIMK2, POLR2K, TTC3, NR1H2, MLLT10, NPEPPS, HDAC4, ADAMTS12, ADAMTS20, LMO4, POLR2L, RBX1, ADAM8, MT1H, MT1X, SMAD3, XIAP, GTF2B, SORD, MDM2, EWSR1, PPARD, ZNF117, ZNF92, GLO1, ZNF91, RING1, POLE, PPARA, CRYZ, EP300, PMPCA, SF3A3, GRIN2A, TRIM26, PRDM2, TRAF1, NR1H3, CBLB, PAPPA, TRIM28, MTA1, BIRC3, SQSTM1, FHL1, ENPP2, GTF2H2, TRIM14, MORC3, ZMYM3, TRIM25, NBR1, CHD4, PTGR1, ZNF638, KPNB1, NR1D2, SHPRH, EEA1, ZMYND11, SEC23A, RGN, TRIP6, ZFHX3, ZYX, CSRP2, QPCT, LONRF1, LONRF2, PCGF3, LONRF3, LACTB2, ZNF385B, TRIM61, DNAJC21, ZMAT1, EARS2, PITRM1, MARCH8, UBR4, PHF19, MEX3C, ZCCHC6, RNF219, BSPRY, ZDHHC20, CPZ, ZFAND6, XAF1, OTUD7B, JADE1, NAPEPLD, ERAP2, GTF2H2C_2, RFWD3, CYHR1, PDZRN4, KDM7A, RNF19B, RNF111, NFXL1, RNF165, UBR3, USP51, USP45, CBLL1, CXXC5, RNF144B, RBBP6, PCGF5, PEG10, TADA2B, SYVN1, TRIM73, TRIM69, MEX3D, RNF130, ZGRF1, GATAD2A, MIB1, ZDHHC17, SIAH1, AEBP1, SLC30A8, UBR1, TRIM42, SIRT2, MSRB3, YAF2, TRIM22, KMT2E, ZDHHC14, CA13, ZCCHC24, MT1M, VPS8, ZCCHC7, ZADH2, ZNF276, ZCCHC9, TAB3, RNF182, AOPEP, RNF152, SREK1IP1, TRIML1, RNF149, RNF169, RNF214, PHC3, KMT2C, ZMIZ2, DBF4B, MYRIP, NEIL3, FBXO30, ZCRB1, ZCCHC10, TMEM163, MARCH1, ZNF675, MICAL1, ADAMTS17, ADAMTS15, ADAMTS18, MORC4, RNF128, SH3RF2, PHF10, CHURC1, FBLIM1, GATAD1, TRIM41, ZFAND2B, RNF141, ZFPM2, RTN4IP1, NANOS1, MYLIP, KAT6B, ZCCHC14, RFFL, NR4A3, JADE3, ESR2, DPF3, CREBBP, KAT6A, TAF15, GATA6, ARHGEF2, USP13, LPP, L3MBTL2, MIB2, TRIM43, PTER, RSPRY1, RNFT2, PDLIM5, AJUBA, CPB2, PDLIM2, EHMT2, ZFR, AGBL1, PRICKLE1, ZMAT2, PGLYRP2, UHRF2, PHF12, HHIP, NR1H4, RSF1, SETDB2, UHRF1, MMP19, P2RX4, S100A13, SCAF11, MTR, BARD1, RBM4B, PYGO2, ZNF2, DIDO1, RNF126, MECR, TRIM62, PHF20, RBM4, CDADC1, SCAPER, TRIM34, WHSC1L1, TRIM8, TRIM9, TRIM6, TRIM4, TRIM2, ZCCHC2, ZNF407, MKRN2, USP44, RNF38, C11orf54, ADAMTS10, SUV39H2, ZDHHC6, ZFAND3, RNF121, MARCH7, LIN28A, SP110, RC3H2, ZFYVE1, APOBEC3G, ZSWIM6, TRIM39, MMP25, MYNN, ATP13A2, CYLD, ZNF331, PDLIM7, ASH1L, MMP26, BAZ1A, RASSF1, RAD18, RNF146, RNF19A, THAP1, RLIM, ZDHHC7, ING3, RBAK, ERAP1, LMCD1, RNF181, ZNRD1, PHRF1, ZSWIM5, ZNFX1, ADAMTS9, RERE, HDAC6, RNF14, DBF4, ZMYM2, ZRANB1, TES, KDM5B, LIMD1, TCF20, APOBEC3B, LIMA1, MKRN1, CHORDC1, TRPS1, ADAMTS1, BAZ1B, ZDHHC2, LNPEP, RABGEF1, ZMYM5, ADAMTS7, ADAMTS6, AMFR, PNMA3, MYT1L, ZMIZ1, RNF150, CIZ1, KMT2B, ADAMTS5, TTF2, ADAMTS8, TRIM33, LIMCH1, TRIM35, PDZRN3, USP22, AGTPBP1, RNF24, TCF19, RNF6, MAN2B2, PIKFYVE, USP20, KDM2A, POLR3K, ZDHHC9, ZNF330, SAMHD1, L3MBTL1, MTF2, DTNA, ARIH1, RNF114, MMP24, LOC440434 |
GO:0008271 | MF | secondary active sulfate transmembrane transporter activity | Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
SLC26A2, SLC26A11, SLC26A1 |
GO:0008273 | MF | calcium, potassium:sodium antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). |
SLC24A3 |
GO:0008276 | MF | protein methyltransferase activity | Catalysis of the transfer of a methyl group (CH3-) to a protein. |
CARM1, PRMT1, N6AMT1 |
GO:0008289 | MF | lipid binding | Interacting selectively and non-covalently with a lipid. |
FABP12, UNC119B, NME4, PLIN1, AP2A2, APOE, APOA2, APOH, DBI, PSAP, ANXA6, CD55, CD36, MAL, PTGS2, ATP5G3, PITPNB, PCYT1A, FABP6, VCP, PEX3, PTEN, HDLBP, FABP5, PPARD, ATP5G2, BAX, PPARA, ARHGEF5, TIAM1, UNC119, MELK, TRIP10, FNBP1L, ACBD5, IQSEC1, APOA5, RASGRP2, BPIFB1, STARD8, BAD, AP2M1, MVB12A, APOLD1, DLC1, FNBP1, OSBPL9, S1PR3, S100A13, SH3GL2, APOL2, ESYT1, OSBPL11, OSBPL6, STARD7, GLTP, STARD9, PCTP, SH3GLB1, STARD13 |
GO:0008296 | MF | 3'-5'-exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. |
POLD1, TREX2 |
GO:0008297 | MF | single-stranded DNA exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. |
MGME1 |
GO:0008301 | MF | DNA binding, bending | The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. |
HMGB3, HMGB1, TOP2A, HMGB2, HMGA2, TERF1, TFAM, HHEX, FOXC1 |
GO:0008307 | MF | structural constituent of muscle | The action of a molecule that contributes to the structural integrity of a muscle fiber. |
NEBL, SORBS2, TPM2, KRT19, TPM1, DMD, MYL6B, CAPN3, MYL9, ACTN2, MYH11, SMTN, MYL6, TPM4, MYBPC1, MYL5, NEXN, ASPH, DAG1, TTN, MYOT |
GO:0008308 | MF | voltage-gated anion channel activity | Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
GPR89A, GPR89B, VDAC2, VDAC3 |
GO:0008309 | MF | double-stranded DNA exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. |
FEN1 |