| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0034715 | CC | pICln-Sm protein complex | A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG. |
SNRPF, SNRPD1, SNRPD2, SNRPD3 |
GO:0034719 | CC | SMN-Sm protein complex | A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. |
SNRPB, GEMIN4, SNRPF, SNRPD1, SNRPD2, SNRPD3, GEMIN5, GEMIN6, GEMIN8, DDX20 |
GO:0034750 | CC | Scrib-APC-beta-catenin complex | A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation. |
CTNNB1 |
GO:0034751 | CC | aryl hydrocarbon receptor complex | A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR. |
AIP |
GO:0034752 | CC | cytosolic aryl hydrocarbon receptor complex | An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP. |
AHR |
GO:0034753 | CC | nuclear aryl hydrocarbon receptor complex | An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT). |
AHR |
GO:0034774 | CC | secretory granule lumen | The volume enclosed by the membrane of a secretory granule. |
POMC, GCG, INS, APOA1, TF, PCSK1, GHRL |
GO:0034991 | CC | nuclear meiotic cohesin complex | A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex. |
RAD21, SMC3 |
GO:0034993 | CC | LINC complex | A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains. |
SYNE2, SUN2 |
GO:0035032 | CC | phosphatidylinositol 3-kinase complex, class III | A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI). |
PIK3C3, NRBF2, PIK3R4 |
GO:0035061 | CC | interchromatin granule | A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs). |
SRSF2, TARDBP, SMC5, SMC6 |
GO:0035068 | CC | micro-ribonucleoprotein complex | A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA. |
TNRC6A, AGO4, AGO2 |
GO:0035097 | CC | histone methyltransferase complex | A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. |
KDM6A, CBX5, RBBP5, KMT2C, PAGR1, ZNF335, ASH2L, HDAC9, KMT2B |
GO:0035098 | CC | ESC/E(Z) complex | A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. |
H2AFY, TRIM37, RBBP4, SUZ12, EZH2, PHF19, HDAC2, EZH1, H2AFY2, MTF2 |
GO:0035101 | CC | FACT complex | An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer. |
TONSL |
GO:0035102 | CC | PRC1 complex | A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. |
CBX7, RING1, PHC3 |
GO:0035145 | CC | exon-exon junction complex | A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. |
SAP18, SRSF1, RNPS1, ALYREF, UHMK1, POLDIP3, UPF3A, PNN, UPF2, THRAP3, R3HCC1, RBM8A |
GO:0035189 | CC | Rb-E2F complex | A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression. |
RB1, E2F1 |
GO:0035253 | CC | ciliary rootlet | A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm. |
KIF5C, APP, PSEN1, RAB28, CROCC, KLC3 |
GO:0035267 | CC | NuA4 histone acetyltransferase complex | A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). |
YEATS4, ACTL6A, ACTB, MORF4L2, EPC1, MEAF6, ING3, MORF4L1, RUVBL2, RUVBL1, TRRAP |
GO:0035327 | CC | transcriptionally active chromatin | The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. |
PSIP1, ESR1, HIST1H1C, ICE2, EXOSC4, EXOSC3, AFF4 |
GO:0035339 | CC | SPOTS complex | A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis. |
ORMDL2 |
GO:0035354 | CC | Toll-like receptor 1-Toll-like receptor 2 protein complex | A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2). |
TLR2, TLR1 |
GO:0035363 | CC | histone locus body | A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body. |
ICE2 |
GO:0035370 | CC | UBC13-UEV1A complex | A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A). |
UBE2V1 |
GO:0035371 | CC | microtubule plus-end | The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. |
CLIP1, DST, CKAP5, MAPRE2, MAPRE1, KIF18B, SPAG5, KIF2C, SLAIN2, CLIP2, MAPRE3, KNSTRN, MYO5A |
GO:0035517 | CC | PR-DUB complex | A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively. |
BAP1 |
GO:0035577 | CC | azurophil granule membrane | The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. |
VAMP7 |
GO:0035686 | CC | sperm fibrous sheath | A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat. |
GSTM3, SPA17 |
GO:0035692 | CC | macrophage migration inhibitory factor receptor complex | A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins. |
CD74, CD44 |
GO:0035693 | CC | NOS2-CD74 complex | A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases. |
CD74 |
GO:0035748 | CC | myelin sheath abaxonal region | The region of the myelin sheath furthest from the axon. |
ITGB1, CNP, DLG1, EXOC4 |
GO:0035749 | CC | myelin sheath adaxonal region | The region of the myelin sheath nearest to the axon. |
ANXA2, CNP, MAG, PTEN, STX4, MPP5 |
GO:0035770 | CC | ribonucleoprotein granule | A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. |
HNRNPL, FXR1, HNRNPA3, GRSF1, DHX30, UHMK1, DDX28 |
GO:0035841 | CC | new growing cell tip | A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth. |
GRM6 |
GO:0035861 | CC | site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
NBN, RNF8, H2AFX, MRE11A, VCP, RAD51, ESCO2, RFWD3, SLF2, SMC5, RNF169, RAD50, SMC6, SLF1, SMARCAD1, RAD18, PRPF19 |
GO:0035867 | CC | alphav-beta3 integrin-IGF-1-IGF1R complex | A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits. |
IGF1, ITGB3, ITGAV, IGF1R |
GO:0035869 | CC | ciliary transition zone | A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. |
UNC119B, SEPT2, PCM1, TMEM107, C5orf30, CC2D2A, B9D1 |
GO:0035976 | CC | transcription factor AP-1 complex | A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes. |
DDIT3 |
GO:0035985 | CC | senescence-associated heterochromatin focus | A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes. |
HMGA1, HMGA2 |
GO:0036020 | CC | endolysosome membrane | The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. |
TLR3, AP2A2, CLTA, AP2S1, AP2B1, AP2M1 |
GO:0036021 | CC | endolysosome lumen | The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. |
CTSL, CTSB, CTSS, CTSK |
GO:0036024 | CC | protein C inhibitor-TMPRSS7 complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7. |
SERPINA5 |
GO:0036025 | CC | protein C inhibitor-TMPRSS11E complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E. |
SERPINA5 |
GO:0036026 | CC | protein C inhibitor-PLAT complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator. |
SERPINA5 |
GO:0036027 | CC | protein C inhibitor-PLAU complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator. |
SERPINA5 |
GO:0036028 | CC | protein C inhibitor-thrombin complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin. |
SERPINA5 |
GO:0036029 | CC | protein C inhibitor-KLK3 complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen. |
SERPINA5 |
GO:0036030 | CC | protein C inhibitor-plasma kallikrein complex | A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein. |
SERPINA5 |
GO:0036038 | CC | MKS complex | A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane. |
AHI1, TCTN2, MKS1, CC2D2A, B9D1 |
GO:0036057 | CC | slit diaphragm | A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. |
IQGAP1, MAGI2, TRPC6, F11R |
GO:0036064 | CC | ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
SSNA1, C21orf2, OFD1, RP2, EZR, TUBG1, AKT1, CENPF, RAB28, EVC, PKD2, PCM1, FAM161A, CFAP126, JADE1, BBS7, AHI1, POC1A, BBOF1, BBS1, TTC8, POC1B, PIFO, DYNC2LI1, IFT81, RPGR, KIFAP3, WDR34, MARK4, CEP19, FOPNL, BBS2, IFT122, CENPJ, CYLD, IFT46, MKS1, SPATA7, WDR35, WRAP73, INTU, B9D1, SSX2IP, DAAM1, FAM179B |
GO:0036126 | CC | sperm flagellum | A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. |
DRD2, ATP2B4, MNS1, RPGR, AK8, SLIRP, IQCG, RNF38, DNAH1 |
GO:0036156 | CC | inner dynein arm | Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. |
DNAH1 |
GO:0036157 | CC | outer dynein arm | Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. |
DNAH5, DNAI1 |
GO:0036195 | CC | muscle cell projection membrane | The portion of the plasma membrane surrounding a muscle cell projection. |
ARPC2, PLEKHO1 |
GO:0036396 | CC | MIS complex | An mRNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and WTAP. |
WTAP, METTL14 |
GO:0036398 | CC | TCR signalosome | A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology. |
STK11 |
GO:0036449 | CC | microtubule minus-end | The end of a microtubule that does not preferentially grow (polymerize). |
FAM175B, ASPM, NIN |
GO:0036457 | CC | keratohyalin granule | A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope. |
CELA2A |
GO:0036464 | CC | cytoplasmic ribonucleoprotein granule | A ribonucleoprotein granule located in the cytoplasm. |
DYNC1I1, ROCK2, STAU1, RPLP0, TUBB, MAPT, RPL28, IQGAP1, ACTB, CDC42, RPS6, RAC1, HNRNPU, FMR1, TUBA1A |
GO:0036477 | CC | somatodendritic compartment | The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. |
RAB5A, STX4 |
GO:0036488 | CC | CHOP-C/EBP complex | A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors. |
CEBPB, DDIT3 |
GO:0036501 | CC | UFD1-NPL4 complex | A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p. |
UFD1L |
GO:0036502 | CC | Derlin-1-VIMP complex | A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome. |
VIMP |
GO:0036513 | CC | Derlin-1 retrotranslocation complex | A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. |
VCP, SYVN1, SVIP, HM13, VIMP, SEL1L, AMFR |
GO:0038039 | CC | G-protein coupled receptor heterodimeric complex | A protein complex that contains two G-protein coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR. |
GABBR2, GABBR1 |
GO:0042022 | CC | interleukin-12 receptor complex | A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits. |
IL12RB1 |
GO:0042101 | CC | T cell receptor complex | A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. |
BCL10, CD4, CD6, SYK, ALCAM |
GO:0042272 | CC | nuclear RNA export factor complex | A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm. |
ATXN1 |
GO:0042382 | CC | paraspeckles | Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei. |
NUDT21, SFPQ, HNRNPM, NONO, PSPC1 |
GO:0042383 | CC | sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
FXYD1, FLOT1, PDE9A, ANXA1, ATP1B1, ITGB1, KRT8, ANXA2, KRT19, LAMP1, DMD, COL6A1, COL6A2, COL6A3, DES, VCAM1, BGN, SLC2A5, LAMA2, BSG, ANK2, PPP3CA, AHNAK, ANK3, DLG1, SNTA1, SNTB1, DAG1, FLNC, SSPN, SLMAP, RYR3, SGCB, BVES, SGCD, RYR2, SGCZ, CIB1, SYNC, FKRP, POPDC2, MYOT, PEMT, SLC27A6, DTNA |
GO:0042405 | CC | nuclear inclusion body | An intranuclear focus at which aggregated proteins have been sequestered. |
NBN, TPR, NUP153, RANBP2, ATXN3, ATXN1, PABPN1, SLF1, RAD18, NXF1, STUB1 |
GO:0042406 | CC | extrinsic component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
TOR1A |
GO:0042470 | CC | melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
RAB27B, SDCBP, TPP1, RAB29, CALU, SEC22B, FLOT1, ATP6V1G2, TFRC, ITGB3, ITGB1, P4HB, CTSD, ANXA2, CTSB, HSP90AA1, ANXA6, SLC3A2, HSP90AB1, CNP, HSPA5, SLC2A1, LAMP1, PDIA4, HSP90B1, TYR, RAB5A, ATP6V1B2, PPIB, AHCY, STOM, CANX, ERP29, PDIA3, YWHAB, BSG, MYH11, SERPINF1, CAPG, PMEL, SLC1A4, FASN, TMED10, MMP14, ANXA11, RAB5C, RAB9A, RAB27A, ATP1B3, NAP1L1, RAB2A, RAB5B, YWHAE, RAB1A, RAC1, YWHAZ, PRDX1, STX3, RAB32, GANAB, GPNMB, PDIA6, SLC1A5, MYRIP, PDCD6IP, GGH, ATP6V0A1, ANKRD27, SYTL2, HPS4, MYO5A, TRPV2 |
GO:0042555 | CC | MCM complex | A hexameric protein complex required for the initiation and regulation of DNA replication. |
MCM3, MCM4, MCM5, MCM7, MCM2, MCM6, TONSL |
GO:0042564 | CC | NLS-dependent protein nuclear import complex | A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore. |
MYBBP1A |
GO:0042567 | CC | insulin-like growth factor ternary complex | A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development. |
IGF1, IGFBP3, IGFBP5 |
GO:0042571 | CC | immunoglobulin complex, circulating | An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. |
IGLL5 |
GO:0042581 | CC | specific granule | Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. |
SNAP23, ANXA3, ANXA11, CLCN3, CRISP3, ADAM8, STX4, STX3, STXBP2, OLFM4 |
GO:0042582 | CC | azurophil granule | Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. |
SNAP23, STX7, MPO, HEXA, DEFA4, ANXA11, STX3, STXBP2 |
GO:0042583 | CC | chromaffin granule | Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. |
CLU |
GO:0042584 | CC | chromaffin granule membrane | The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. |
SYT1, SRI |
GO:0042585 | CC | germinal vesicle | The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity. |
AURKA, MARCKS |
GO:0042587 | CC | glycogen granule | Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface. |
PPP1R3D, FASN, PCYT1A, PPP1CA, PPP1CB, PPP1R3B |
GO:0042588 | CC | zymogen granule | A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. |
GNAI3, SRGN, HSPD1 |
GO:0042589 | CC | zymogen granule membrane | The lipid bilayer surrounding a zymogen granule. |
RAB27B, SCAMP1, TMED10, VAMP2, STX3, TMED2, STXBP2, DMBT1 |
GO:0042599 | CC | lamellar body | A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. |
SFTPC |
GO:0042612 | CC | MHC class I protein complex | A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. |
HLA-B, HLA-E, HLA-G, HLA-A, HLA-F, B2M, MR1 |
GO:0042613 | CC | MHC class II protein complex | A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. |
HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, HLA-DRB4, HLA-DOB, HLA-DPA1, HLA-DMB, HLA-DRB3, HLA-DRB5 |
GO:0042622 | CC | photoreceptor outer segment membrane | The membrane surrounding the outer segment of a vertebrate photoreceptor. |
DHRS3, OPN1SW, CNGA1, GNB1, NAPEPLD, PHLPP2 |
GO:0042627 | CC | chylomicron | A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. |
APOA1, APOE, APOA2, APOC1, APOC3, APOH, APOB, LPL, APOBR, APOA5, LSR |
GO:0042629 | CC | mast cell granule | Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. |
SNAP23, PIK3CD, ANXA1, LYN, SRGN, KIT, AKR1B1, CXCR2, PIK3CG, CPLX2, NR4A3, S100A13 |
GO:0042641 | CC | actomyosin | Any complex of actin, myosin, and accessory proteins. |
MYH9, HDAC4, DBN1, CDC42BPA, KAT2B, MYO5A, CDC42BPB |
GO:0042643 | CC | actomyosin, actin portion | The actin part of any complex of actin, myosin, and accessory proteins. |
ACTC1 |
GO:0042645 | CC | mitochondrial nucleoid | The region of a mitochondrion to which the DNA is confined. |
KIAA0391, CLPX, SLC25A5, DBT, MPG, LRPPRC, VDAC2, ACADVL, DNA2, POLG, HADHB, TFAM, SSBP1, GRSF1, DHX30, SUPV3L1, TEFM, PEO1, MTERF1, ELAC2, UQCC2, DDX28, ATAD3A, POLDIP2 |
GO:0042719 | CC | mitochondrial intermembrane space protein transporter complex | Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. |
TIMM10B |
GO:0042734 | CC | presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
APBB1, GRM8, CASK, GRM6, FBXO45, FOSL1, SYT1, ADORA1, SNAP25, FMR1, KCNA1, GRIN2A, STX3, PICALM, GRM3, NECTIN1, ERC1, ZDHHC17, DENND1A, KCTD12, GPER1, GABBR1, NRXN1, RIMS2, SNCAIP |
GO:0042765 | CC | GPI-anchor transamidase complex | An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor. |
PIGK, PIGT, PIGU |
GO:0042788 | CC | polysomal ribosome | A ribosome bound to mRNA that forms part of a polysome. |
EEF2, NR0B1, RPL7A, FMR1, NUFIP2 |