GO:0032541

CC

cortical endoplasmic reticulum

A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.

ASPH

GO:0032545

CC

CURI complex

A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.

RRP7A

GO:0032580

CC

Golgi cisterna membrane

The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.

GOLGA8A, GPR89A, GOLIM4, ASAP2, B4GALT5, B4GALT4, GPR89B, B4GALT1, ST6GAL1, FUT1, FUT4, BCAP31, NUCB1, GOLGA2, GALNT2, GALNT1, FUT2, ST3GAL1, ST3GAL3, ST3GAL4, TMED2, ST3GAL2, CHSY3, CHSY1, HACE1, UXS1, CSGALNACT1, GOLGA1, YIPF5, APH1A, ST6GAL2, ARAP1, FUT8, INPP5E, B4GALT6, NAGPA, RAB21, TMED3, SAR1B

GO:0032584

CC

growth cone membrane

The portion of the plasma membrane surrounding a growth cone.

GAP43, NECTIN1, EXOC4, LAMP5, EXOC7, TRPV2

GO:0032585

CC

multivesicular body membrane

The lipid bilayer surrounding a multivesicular body.

RAB27B, PMEL, RAB27A, ATP13A2, NDFIP2

GO:0032587

CC

ruffle membrane

The portion of the plasma membrane surrounding a ruffle.

MYO1C, SPRY2, PIP5K1C, PDE9A, ITGB3, ITGB1, ITGAV, HSP90AA1, ITGA5, TPM1, FGR, LCP1, EZR, NME1, ARF4, CFL1, APC, AKT2, NF2, TIRAP, RAC1, EEF1A1, ADAM17, TWF1, PTPRJ, EPS8, TIAM1, IFIT5, KANK1, PLEKHO1, THEM4, RASGRP2, FGD2, PDPN, C2CD5, WWC1, ARHGEF2, SH3YL1, SPATA13, DLC1, CIB1, AIF1L, FERMT1, INPP5K, PACSIN1, SPRY4, TRPV4, ARHGEF4, MYO6, MACF1, TLN1

GO:0032588

CC

trans-Golgi network membrane

The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

SCAMP2, STX6, VAMP4, LGR5, RHOBTB3, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, APP, CLTA, IGF2R, HLA-DRB4, HLA-DPA1, RAB9A, ARFIP1, AP1S2, AP1S1, HLA-DRB3, AP1B1, RAB31, COG2, VAMP3, HLA-DRB5, RABEPK, VPS52, MARCH1, USP6NL, LGR6, TMEM165, COG6, AP4S1, MMP24

GO:0032590

CC

dendrite membrane

The portion of the plasma membrane surrounding a dendrite.

ATF4, WLS, GABARAPL1, LAMP5

GO:0032591

CC

dendritic spine membrane

The portion of the plasma membrane surrounding a dendritic spine.

ATP2B1, TRPV1, GPER1

GO:0032592

CC

integral component of mitochondrial membrane

The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

BID, MFF, ABCB10

GO:0032593

CC

insulin-responsive compartment

A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.

SLC2A4, RAB4B, DENND4C, MYO5A

GO:0032777

CC

Piccolo NuA4 histone acetyltransferase complex

A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p.

EPC2, EPC1, ING3

GO:0032783

CC

ELL-EAF complex

A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae.

EAF1

GO:0032797

CC

SMN complex

A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.

ZPR1, GEMIN4, FMR1, GEMIN5, GEMIN6, GEMIN8, DDX20

GO:0032798

CC

Swi5-Sfr1 complex

A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces).

SWI5

GO:0032807

CC

DNA ligase IV complex

A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p.

XRCC4

GO:0032809

CC

neuronal cell body membrane

The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.

ATP2B1, GABRA5, SLC4A8, FLRT1

GO:0032838

CC

cell projection cytoplasm

All of the contents of a cell projection, excluding the plasma membrane surrounding the projection.

AKR1B1

GO:0032839

CC

dendrite cytoplasm

All of the contents of a dendrite, excluding the surrounding plasma membrane.

ADA, CANX, MAPK1, DLG4, WLS, UHMK1, GABARAPL1

GO:0032937

CC

SREBP-SCAP-Insig complex

A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane.

INSIG1, SREBF2

GO:0032982

CC

myosin filament

A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.

MYH11, ACTG2, MYBPC1, MYH2, MYH4

GO:0032991

CC

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

CRTAP, PPIB

GO:0032993

CC

protein-DNA complex

A macromolecular complex containing both protein and DNA molecules.

SOX12, JUP, JUND, NFYB, KDM5A, CTNNB1, DDIT3, HMGA2, HHEX, NFYC, CHD4, SUZ12, TCF7L2

GO:0032994

CC

protein-lipid complex

A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other.

PEX3

GO:0032996

CC

Bcl3-Bcl10 complex

A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus.

BCL3

GO:0033010

CC

paranodal junction

A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.

AKR1B1, SIRT2, JAM3

GO:0033017

CC

sarcoplasmic reticulum membrane

The lipid bilayer surrounding the sarcoplasmic reticulum.

ATP2A2, PLN, SRI, DMPK, ASPH, CAMK2D, ITPR2, RYR3, CHERP, SYNE2, RYR2, JSRP1, TMEM38B

GO:0033018

CC

sarcoplasmic reticulum lumen

The volume enclosed by the membranes of the sarcoplasmic reticulum.

CALU, CALR

GO:0033063

CC

Rad51B-Rad51C-Rad51D-XRCC2 complex

A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.

RAD51C, RAD51D

GO:0033065

CC

Rad51C-XRCC3 complex

A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.

RAD51C

GO:0033093

CC

Weibel-Palade body

A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.

VWF, EDN1, ECE1, RAB27A

GO:0033116

CC

endoplasmic reticulum-Golgi intermediate compartment membrane

The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.

GOSR2, SURF4, SEC22B, F8, SERPINA1, TGFA, INS, CD55, F5, FOLR1, AREG, KDELR1, CSNK1D, TMED10, BCAP31, CTSC, RAB2A, GOLGA2, TMED2, MCFD2, SPPL3, PIEZO1, ERGIC1, VMP1, ERGIC2, ASPSCR1, RAB1B, SLC35C2, CTSZ, LAMP5, ERGIC3, TMED5, TMED3

GO:0033162

CC

melanosome membrane

The lipid bilayer surrounding a melanosome.

TH, TYR, RAB7A, RAB32, SLC45A2

GO:0033167

CC

ARC complex

A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.

DICER1

GO:0033176

CC

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

ATP6V1D

GO:0033179

CC

proton-transporting V-type ATPase, V0 domain

A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.

ATP6V0E1, ATP6V0D1

GO:0033180

CC

proton-transporting V-type ATPase, V1 domain

A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A.

ATP6V1B2, ATP6V1C1, ATP6V1F, ATP6V1C2

GO:0033185

CC

dolichol-phosphate-mannose synthase complex

A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.

DPM3

GO:0033186

CC

CAF-1 complex

A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.

RBBP4, CHAF1A, CHAF1B

GO:0033193

CC

Lsd1/2 complex

A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.

TAL1

GO:0033256

CC

I-kappaB/NF-kappaB complex

A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm.

NFKB1, RELB, RELA, REL

GO:0033257

CC

Bcl3/NF-kappaB2 complex

A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription.

BCL3

GO:0033263

CC

CORVET complex

A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p.

VPS8

GO:0033268

CC

node of Ranvier

An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.

BIN1, ANK3, DLG1, DAG1, SPTBN4

GO:0033269

CC

internode region of axon

An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath.

TUBB4A, PARD3

GO:0033270

CC

paranode region of axon

An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath.

MAG, KCNA1, ANK3, SIRT2, SPTBN4, KIF13B, EPB41L3

GO:0033276

CC

transcription factor TFTC complex

A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.

SUPT3H, TADA3, TAF10, TAF5, TAF12, TAF9B, TRRAP

GO:0033290

CC

eukaryotic 48S preinitiation complex

A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.

EIF3J, EIF2S1, EIF3B, EIF3A, EIF3K

GO:0033291

CC

eukaryotic 80S initiation complex

A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region.

RPL38

GO:0033391

CC

chromatoid body

A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).

ARNTL, EIF4E, NSUN2

GO:0033503

CC

HULC complex

A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2.

UBE2A, UBE2B

GO:0033565

CC

ESCRT-0 complex

A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals.

STAM2, STAM

GO:0033588

CC

Elongator holoenzyme complex

A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes.

IKBKAP, ELP6, ELP4, ELP3

GO:0033593

CC

BRCA2-MAGE-D1 complex

A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth.

BRCA2

GO:0033596

CC

TSC1-TSC2 complex

A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.

TSC2

GO:0033597

CC

mitotic checkpoint complex

A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20.

BUB3

GO:0034045

CC

pre-autophagosomal structure membrane

A cellular membrane associated with the pre-autophagosomal structure.

ULK1, ATG12, RAB7A, WIPI1, RB1CC1, ATG2B, RAB1B, WDR45, WIPI2

GO:0034098

CC

VCP-NPL4-UFD1 AAA ATPase complex

A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).

UBXN7, VCP, CAV1, UFD1L, FAF2, FAF1

GO:0034271

CC

phosphatidylinositol 3-kinase complex, class III, type I

A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.

PIK3R4

GO:0034272

CC

phosphatidylinositol 3-kinase complex, class III, type II

A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.

PIK3R4

GO:0034274

CC

Atg12-Atg5-Atg16 complex

A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.

ATG12

GO:0034359

CC

mature chylomicron

A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph.

APOB

GO:0034360

CC

chylomicron remnant

A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver.

APOB

GO:0034361

CC

very-low-density lipoprotein particle

A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.

APOA1, APOE, APOA2, APOC1, APOC3, APOH, APOB, LPL, VLDLR, APOBR, APOA5, LSR, VIMP, APOO, PCYOX1

GO:0034362

CC

low-density lipoprotein particle

A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.

LDLR, APOE, APOB, APOBR, PLA2G7, LSR, SORL1, VIMP, APOO

GO:0034363

CC

intermediate-density lipoprotein particle

A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL).

APOE, APOC3, APOB

GO:0034364

CC

high-density lipoprotein particle

A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.

ABCA1, APOA1, APOE, APOA2, APOC1, APOH, SAA1, SAA2, PON1, HDLBP, APOA5, APOO

GO:0034365

CC

discoidal high-density lipoprotein particle

A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase).

APOA1

GO:0034366

CC

spherical high-density lipoprotein particle

A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).

APOA1, APOA2, APOC3, CLU, PON1

GO:0034388

CC

Pwp2p-containing subcomplex of 90S preribosome

A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.

TBL3, WDR3, UTP18

GO:0034399

CC

nuclear periphery

The portion of the nuclear lumen proximal to the inner nuclear membrane.

IPO5, TNPO2, RANBP6, MAPT, TPR, ATF7, ATF4, NUP153, NUP107, KPNB1, NUP93, IPO4, AHCTF1, NUP205, EBNA1BP2

GO:0034448

CC

EGO complex

A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Meh1p, and Slm4p.

RRAGC, RRAGD

GO:0034451

CC

centriolar satellite

A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.

OFD1, FLOT1, PCNT, KRT18, PCM1, CCDC14, SDCCAG8, HOOK3, PIBF1, FOPNL, SPAG5, CCDC113, EXOC7, SSX2IP

GO:0034455

CC

t-UTP complex

A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.

UTP4, NOL11

GO:0034456

CC

UTP-C complex

A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p.

RRP7A

GO:0034464

CC

BBSome

A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B.

BBIP1, BBS7, BBS1, TTC8, BBS2

GO:0034515

CC

proteasome storage granule

A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state.

PSMD2

GO:0034518

CC

RNA cap binding complex

Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA.

NCBP1, NCBP3

GO:0034657

CC

GID complex

A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p.

MAEA, RMND5B, RMND5A

GO:0034663

CC

endoplasmic reticulum chaperone complex

A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.

P4HB, HSPA5, HSP90B1, PPIB, PDIA6, DNAJC10, HYOU1

GO:0034665

CC

integrin alpha1-beta1 complex

An integrin complex that comprises one alpha1 subunit and one beta1 subunit.

ITGB1

GO:0034666

CC

integrin alpha2-beta1 complex

An integrin complex that comprises one alpha2 subunit and one beta1 subunit.

ITGB1, LYN, ITGA2

GO:0034667

CC

integrin alpha3-beta1 complex

An integrin complex that comprises one alpha3 subunit and one beta1 subunit.

ITGB1, ITGA3

GO:0034673

CC

inhibin-betaglycan-ActRII complex

A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B.

INHA, ACVR2A, TGFBR3

GO:0034676

CC

integrin alpha6-beta4 complex

An integrin complex that comprises one alpha6 subunit and one beta1 subunit.

ITGA6

GO:0034677

CC

integrin alpha7-beta1 complex

An integrin complex that comprises one alpha7 subunit and one beta1 subunit.

ITGB1

GO:0034678

CC

integrin alpha8-beta1 complex

An integrin complex that comprises one alpha8 subunit and one beta1 subunit.

ITGB1

GO:0034679

CC

integrin alpha9-beta1 complex

An integrin complex that comprises one alpha9 subunit and one beta1 subunit.

ITGA9

GO:0034680

CC

integrin alpha10-beta1 complex

An integrin complex that comprises one alpha10 subunit and one beta1 subunit.

ITGA10, ITGB1

GO:0034681

CC

integrin alpha11-beta1 complex

An integrin complex that comprises one alpha11 subunit and one beta1 subunit.

ITGB1, ITGA11

GO:0034683

CC

integrin alphav-beta3 complex

An integrin complex that comprises one alphav subunit and one beta3 subunit.

ITGB3, ITGAV

GO:0034684

CC

integrin alphav-beta5 complex

An integrin complex that comprises one alphav subunit and one beta5 subunit.

ITGAV, ITGB5

GO:0034686

CC

integrin alphav-beta8 complex

An integrin complex that comprises one alphav subunit and one beta8 subunit.

ITGAV, ITGB8

GO:0034687

CC

integrin alphaL-beta2 complex

An integrin complex that comprises one alphaL subunit and one beta2 subunit.

ITGB2

GO:0034702

CC

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

LRRC8A

GO:0034704

CC

calcium channel complex

An ion channel complex through which calcium ions pass.

PRKACA, CALM2, PDE4D, AKAP6, CAMK2D, PPP2R4, RYR3, MICU2, RYR2

GO:0034705

CC

potassium channel complex

An ion channel complex through which potassium ions pass.

KCNK1

GO:0034706

CC

sodium channel complex

An ion channel complex through which sodium ions pass.

SCNN1A, SCNN1G

GO:0034707

CC

chloride channel complex

An ion channel complex through which chloride ions pass.

FXYD1, CLIC1, BEST1, CLIC3, CFTR, GABRA5, CLCNKA, CLCNKB, ANO6, BEST3, CLIC6, TTYH1, ANO2, CLIC5

GO:0034709

CC

methylosome

A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.

SNRPB, SNRPF, SNRPD1, SNRPD2, SNRPD3, ERH, PRMT1