GO:0005884

CC

actin filament

A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.

WIPF3, ARHGAP6, DAPK3, WDR1, COBL, FYN, ACTN1, LCP1, RAC2, EZR, RHOQ, TMOD1, LMOD1, CORO1A, ACTN2, IQGAP1, CAPZB, RAC1, ACTC1, TEK, AKAP13, MYO9B, CTTN, PLS1, AMOT, PALLD, PAWR, AIF1L, CORO1B, MYO5A

GO:0005885

CC

Arp2/3 protein complex

A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.

ARPC2, ARPC3, ARPC4, ACTR3, ACTR2

GO:0005886

CC

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TBC1D3D, TBC1D3E, KIAA0922, TBC1D3F, MYO1G, MYO1C, SNAP23, FXYD1, AIP, KCNK1, TLR4, RHOD, APBB1, GRM8, CLIC1, TNFRSF11B, PIK3CD, WASL, PIK3C2A, BTN3A3, KRIT1, CHL1, SDCBP, CLDN4, PLPP1, PLPP3, ARHGAP33, KCNK3, IRS4, ADAM10, ITGB1BP1, NRP1, TNFSF11, TNFRSF10C, TSPAN4, TAX1BP3, PCDH17, RGS12, CASK, RAB29, SYNJ2, SMAD7, FYB, ANGPT2, PLSCR1, ZNF185, SLC22A1, FANCG, OGT, GRM6, GPR37, HDAC3, NCAM2, STX7, SLC16A3, SLC31A1, ABCC4, ABCC5, RGS5, ASAP2, FLRT2, ADAM12, IRAK2, SPINT2, AQP9, MAP3K7, DHH, RASA4, MGAM, CACNA1G, ATP8B1, CA12, AKAP10, SPRY2, SPRY1, PRC1, RGS10, ITM2A, CYTH3, STX6, SSNA1, C21orf2, TYROBP, PPP1R12B, GNG7, ADCY3, TRAK2, FZD6, PPL, NRP2, PLXNC1, ADCY9, NMT2, TLR5, TLR2, SLC16A7, LPXN, CTNND1, SLC19A2, RAMP1, RAMP3, FCGR3B, PLXNA2, SDC3, ADAM23, FZD7, AOC2, ATP9A, ROCK2, MFAP3L, COBL, PHACTR2, LRP5, SEMA7A, HMMR, ATP6V1G1, ENTPD6, ENTPD3, FLNB, TULP3, GPR32, TECTA, LGR5, GPC4, TNFRSF21, STX11, SKAP2, CRCP, ITGA10, LRP6, ADAP1, RP2, SLC22A3, GABBR2, PAK3, ARL6IP5, FLOT1, SLC22A5, BEST1, SRP72, DXO, STK17B, AQP8, SLIT2, PLEKHG5, LRIG2, ERLIN2, DKK1, ABCA8, SLCO2B1, AP2A2, UNC5C, SNX4, ABCA1, VNN1, SLC2A10, STAMBP, DIRAS3, SNAP29, STAU1, RECK, BCL10, DNAL4, ACTL6A, F8, GOT2, EGFR, AK1, F2, PLG, PLAU, CFB, ADA, CA2, SERPINC1, C3, KNG1, NRAS, KRAS, LDLR, TGFA, TGFB1, PENK, GCG, IGF2, TNF, CD4, HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, APOA1, APOE, FGA, FGB, FGG, GYPA, AMBP, TFRC, ESR1, RAF1, ANXA1, APOB, PRNP, CD74, KRT1, GAPDH, ERBB2, NTRK1, HSPB1, CYBB, GNAI2, SLC4A2, GYPC, IGF1, ATP1B1, APP, ITGB3, ITGB2, S100A8, SERPINE1, ALPL, ICAM1, ITGB1, PRKCB, INSR, FYN, S100A9, ENO1, GPI, ITGAV, LPL, CSF1R, ANXA2, ADRB2, HSP90AA1, LYN, IGF1R, NGFR, CHRM2, CD55, SLC3A2, MMP2, MME, CD14, PTPRC, MET, ADRB1, ITGA5, VIM, KRT19, GNAI3, STS, RPSA, IL6R, ENO2, GSTP1, CD48, HMGB1, CLTA, ANXA4, CNP, WNT2, PDGFRB, FGR, LCT, UCHL1, FURIN, C4A, C4B, TBC1D3H, UBC, RAP2A, AR, RRAS, PTPRF, MAPT, TFPI, KIT, CD28, HSPD1, GHR, HSPA5, SLC2A1, SLC2A3, ITGAM, RALA, RALB, LAMP1, FGFR1, PSKH1, F5, FCGR1A, FCGR2A, ANXA3, ACTN1, ACE, XRCC5, IFITM1, GP1BB, TDGF1, LAMP2, CFTR, NCAM1, EEF2, HLA-E, HLA-DRB4, LCP1, PRKAR2A, ENO3, ADRB3, SELL, CD99, CPM, DRD2, PLA2G2A, PKM, HSP90B1, SLC2A4, IDE, IL1R1, JUP, ETS2, PVR, RAC2, IFNGR1, B4GALT1, ACPP, EZR, FOLR1, VAV1, CD46, CD1D, DSP, ALOX15, CD44, ITGB4, PDGFRA, PECAM1, EPCAM, PRLR, GNB3, SELE, CD36, CPE, IL7R, PLCG2, RHOQ, IFNAR1, PRKCA, ITGA2, GJA1, NPR3, GAP43, HLA-G, PTPN2, CR1, LGALS3, ITGB5, ADRA2B, IL1RN, SDC1, PAM, CDH2, CD58, VCAM1, CD53, ATP2B1, HLA-DPA1, CD33, CHRM3, TNFRSF1B, RAB3B, RAB5A, TRH, NPR2, ITGAX, CAPN3, EFNA1, MAG, ATP6V1B2, ATP6V1C1, FLNA, S1PR1, FPR1, CNR1, SYT1, KITLG, NT5E, C5AR1, ZP3, FGFR2, ERBB3, SDHB, CD9, COMT, ENPP1, SLC2A5, CA4, LHCGR, MRC1, ITGA6, ANOS1, PTPRD, TNFSF4, ATP2B4, FSHR, CXCR2, APC, FPR2, ADRA1D, EDNRA, PTAFR, F2R, AZGP1, FAS, MT3, NPY1R, ITGA3, ITGB8, KLRC1, CD27, ACVR2A, DPP4, IL1R2, PIK3R1, SSFA2, HTR2C, ADORA2B, CTGF, EPHA3, EPHB2, LTK, NOS3, CD40LG, MARCKS, CNGA1, GNA11, BLVRB, CCND3, MIP, HLA-A, HLA-F, AVPR2, ADSS, SLC6A1, CHRNA5, LRPAP1, ADORA1, AGTR1, OXTR, SSTR1, GNRHR, CORO1A, PRKAR2B, SDC4, SLC6A6, GABRA5, AKT1, AKT2, FCGR2B, CCKBR, MC4R, GPR183, GBP1, STX2, ACSL1, CDH5, LSP1, ABCC1, SDC2, CD68, GRK5, HTR7, GPC1, BTC, USP6, CTNNA1, CTNNB1, PHB, NF2, RDX, SSTR5, ADRA1A, HRH1, ADRA1B, PTGER4, IRS1, MYH9, ACTN2, BSG, ADRBK2, FLT4, GJC1, CHRNA7, NUDT1, BMPR1A, ACVR1B, TGFBR1, LTBR, SCNN1A, TGFBR2, SNCA, BRCA1, IFNGR2, SPAM1, ITGAE, FEN1, PLA2G5, IL6ST, STAT3, MDH2, PMEL, OPRL1, ETV5, AQP2, CD200, RGS2, WNT5A, CSK, SLC19A1, ADCYAP1R1, HTR2B, PRKCI, PIK3CA, PIK3CB, EPS15, DPP6, IL12RB1, LIFR, SLC1A3, SLC1A2, SLC1A4, GDF5, PTGFR, PTGER3, PTGER2, MCAM, GRK6, SYK, KIR3DL2, PHKA2, PHKA1, NSF, NOTCH1, MAP1B, IQGAP1, OR3A3, SLC6A8, MTNR1A, ATP5O, GRIA4, LIMS1, GLIPR1, NPBWR1, GLRB, LEPR, CD151, IFNAR2, SLC1A6, CSNK1D, PIK3CG, CD97, TRPC1, NPY2R, PTH2R, SLC11A1, SLC11A2, MTNR1B, FASN, CCT3, PCYT1A, ARL4D, TMED10, NUMB, PSEN1, HINT1, RGS3, RGS4, RGS7, PSEN2, GSK3B, SEPHS1, AGTR2, GNAQ, GNG4, MMP14, SLC26A2, METAP2, KNTC1, LRBA, RNF144A, BCAM, ATP1A2, RAB5C, RAB9A, RAB28, SCNN1G, PLCD1, MMP15, MMP16, IRAK1, CAV2, CLCN3, CLCNKA, CLCNKB, PLXNA3, VAMP7, ADCY7, SLC7A2, STAT2, MSH6, EFNA4, EFNB2, EFNA5, DAPK1, SUCLG1, RABGGTB, AP2S1, CACNB3, CACNA2D1, ATP12A, ATP1B3, EPHA5, EPHB4, EPHB1, EPHA4, GAS1, EMP1, EMP2, EMP3, EIF5, SLC12A2, RRAD, MFAP3, F2RL1, CDH6, CDH11, CDH12, CDH13, CDH15, NPEPPS, TMEM50B, WNT3, PRSS12, HSD17B7, JAM2, ANTXR2, TIRAP, FXYD4, CD81, PLP1, PTEN, PPP4C, ACTB, RAC3, ZP1, SNAP25, CDC42, RAB4B, RAB5B, CXCR4, UBE2D3, RAP2B, RHOA, STXBP1, B2M, GNG11, RRAS2, TSPAN5, PPP1CA, CALM2, NCS1, RAB11A, RHOB, RAP1A, GNB1, GNB2, RPS27A, UBA52, GRB2, RAC1, AP2B1, VAMP2, GNAI1, UBE2B, DYNLL1, GNG5, ACTG1, PAFAH1B2, CXADR, SIRPA, ADAM8, DLG4, PIP4K2B, OLR1, BTN3A2, JAG1, ADAM17, HLA-DRB3, NUCB2, SLC7A9, SMAD3, ARF1, ARF5, GNAS, SHC2, DAB2, VLDLR, HSPG2, PKD1, LRP2, HDLBP, CDK5, CDK16, MDM2, CD83, IL5RA, PMP22, ANK2, HMGCS1, IFITM3, IL1RL1, SLC7A5, MC2R, XPC, EWSR1, OCRL, ROR1, SP3, DSC2, MAP2K1, TEK, GNA12, CAV1, PLAUR, NOTCH2, PRKCQ, CD164, YWHAH, PTK2, ZBTB16, PRKCD, CALD1, SLC18A2, APLP2, C1QBP, TJP1, POLE, SOS1, TNK2, PCDH1, IL10RB, DDR1, SLC20A2, CD47, DMPK, KCNA1, AHNAK, FCHO2, SMAGP, APOBR, BST2, ARHGEF5, KCNMA1, ASPH, KCNH2, RAB40B, STX4, CNTN1, CDH17, MERTK, GRIN2A, HYAL2, PTPRJ, ANK3, DLG1, PTP4A2, ABR, TIAM1, MALL, STRN3, BAMBI, FADD, PAK2, CBLB, PTGDR, STX3, G3BP1, CLN3, GRB10, IFIT5, SLC14A1, PPIL2, ORC1, ILK, SLC39A6, LSAMP, NFATC2, IL18R1, TCIRG1, GPM6B, MTM1, TRPC3, SERINC3, CAMK2D, PKD2, NAE1, TDG, DGKZ, SEMA5A, MTMR1, PTCH1, FHL1, ACVR2B, SHROOM2, ITGA9, ENPP2, BMPR2, KLF9, CACNA1C, CEACAM7, KCNC3, RAB33A, DAG1, DSG2, ARHGEF7, SCARF1, EIF2B1, SELPLG, CTTN, FLNC, GPR176, GRB14, KCNJ12, FAT1, ITPR2, ITPR3, INPP5A, ITPR1, KCNJ11, KANK1, MELK, RFTN1, GRM3, GPNMB, CLCA4, MORF4L2, JOSD1, SLC39A14, KARS, KIF14, ACOX1, PDIA6, PLCL1, PRKD1, NECTIN1, ERBB4, ANGPT1, MTFR1, P2RY14, TLR1, SHB, TGFBI, TRADD, TRIP6, SLC1A5, NPY5R, MSMO1, ITSN1, STXBP2, VAMP3, CACNA1E, RAB11B, ZYX, SEPT7, ADRM1, UAP1, SLC15A2, PKN1, PKN2, ASIC2, OCLN, DBN1, PTPRO, CYP51A1, AOC3, DUOXA1, MICB, MICA, PDS5A, ERCC6L, RALGAPA2, SLC4A8, HLA-DRB5, HFE, LRRFIP1, CHD9, PIGY, CCDC88A, ANO6, NKAIN1, ATP13A5, RFTN2, CYBRD1, SDK2, TMEM97, IGSF11, BCORL1, ALG10B, RALGPS1, TJAP1, GNAS, DGKK, COLEC12, MUC21, FNBP1L, THEM4, ABCC10, STXBP5, GPR158, WLS, COL13A1, ANKRD20A1, CROCC, GPR157, RIF1, NKAIN2, CHIC1, DENND4C, LRRC16A, ZDHHC20, TNS2, TMEM198, STEAP4, LAIR1, LAMTOR1, JADE1, OR52E8, TBC1D3C, STYK1, RGS7BP, TENM4, MFSD5, RGMB, JMJD6, MAST2, ERAP2, SLC27A4, SLC39A4, LRRC8B, SLC27A1, PPIP5K1, TMEM65, CNST, ADGRD1, AGTRAP, ANKRD11, PARM1, C6orf89, OLFM4, SEZ6L2, LRIG3, GLDN, BNC2, SLCO4C1, QSOX2, RAPH1, PREX2, SV2A, RHOU, SV2B, RAB11FIP2, ARC, RASGRP2, SLC16A14, SLC16A9, PLPPR4, SLC36A1, DCXR, SDK1, NET1, SPRED1, RABEPK, PXK, PHLDB2, GPR126, ZBTB33, TTC7B, MAGI2, SLC51A, CD163, SERINC5, P2RY8, SGMS1, SLC26A11, RASSF3, CHD1L, TRIM69, RALGPS2, LSR, DGKH, TMEM219, FRAS1, COL23A1, PDPN, GPSM1, C2CD5, MIB1, TMPRSS6, CRLF3, SIAH1, RELL1, PLEKHH2, NOSTRIN, VSTM4, SERPINA12, SLC44A2, ITPRIP, LRRC8A, SLC30A8, SULF2, SULF1, CNTN4, SIRT2, KLHL7, PALM2, FAM126B, TMEFF1, ANKRD13A, KIAA0319L, KMT2E, XRN1, UNC5B, CPAMD8, TBC1D3, NLGN4X, SPG20, GPC2, CRIPAK, ARHGEF28, LYPD1, ABHD12, NLGN1, MUC15, MPP5, SFRP1, SLC44A3, ARHGEF39, AFAP1L2, TAB3, ARRDC1, ARFGAP2, AOPEP, CD177, NIPA2, ENAH, MFSD2A, PCSK9, SERBP1, DAGLB, SLC44A5, ARRDC4, LRRC16B, RGS22, BVES, PLPP5, TRPV1, FLCN, NUP35, GPRC5A, DNER, STXBP6, SEMA6D, TSPAN14, OR5A2, OR5L2, OR14C36, SVIP, LILRB1, SGMS2, TPCN2, INADL, PCDH19, KCNG3, CYP2W1, GSDMB, SPATA20, SLC35G2, ENOX1, KIAA1524, MARCH1, SPPL3, SPPL2A, HM13, MRAP, BICD2, TRPM4, DLG5, KCNV2, LRRC8C, SYTL5, FAT3, IGDCC4, RAPGEF6, PARD3, PAQR8, SH3TC2, ATP8B4, SLC16A10, SCARB1, FRS2, RAB2B, CEMIP, SLC20A1, SLC38A5, BLNK, SECTM1, APH1B, SLC44A1, ARAP3, IPCEF1, STAB2, SLC5A11, LIPH, PALLD, GPR98, CLEC4D, CACNG8, DNAJC9, MYLIP, RFFL, RAPGEF4, CLEC2B, AQP3, PIEZO1, SLC7A6, ELMO1, SLC9A6, NDRG1, SGCD, FCGR1B, RYR2, USP6NL, HTRA1, SYMPK, DIO2, NRCAM, INPP5D, GHSR, GLG1, SLC5A5, FGF13, RAB8B, SLCO2A1, RIT1, TNFRSF25, ATP6V0A1, LPP, MR1, KISS1R, PMEPA1, ADIPOR1, EXOC4, PNPLA2, TTC17, ARRDC3, SLC22A18, APH1A, SYTL4, GPR146, TLCD1, AP2M1, RASD2, REPS1, RAB39B, C11orf24, CDCA5, SLC47A1, CPNE2, S100A16, PERP, MRAP2, VMP1, SLC41A3, AJUBA, PAWR, ITCH, SLC41A2, DNAJC1, FAM84B, EXOC2, FCRL1, APOLD1, KCTD7, FRMD6, C8orf37, PTCHD1, SLC46A1, ANKRD27, CLIC6, ARAP1, ERMAP, NEDD4L, PLIN4, GSDMA, TRPM7, MAGI1, OR2A5, PANX2, PANX1, FNBP1, TRIB3, RANBP9, RASL10B, MYADM, SRPK1, CEP89, KCNK17, FAM129B, CSF3R, HBEGF, S1PR3, NEU1, GPER1, PLIN2, MPHOSPH8, MPHOSPH9, PKP4, P2RX4, OSMR, CHP1, MGLL, FEZ1, HSD17B10, LITAF, MGST2, SLC29A1, CIB1, HAUS7, PRRT1, PKP2, SH3GL2, MAPKAP1, VIMP, TMEM47, HEPH, CORO1B, CPPED1, SDF4, ESYT1, MARVELD1, INPP5K, UPK3B, SYT11, NDC1, PDCD10, ABHD6, ADI1, KATNB1, TAPBPL, SORBS1, JAM3, TRPM6, LGR4, CLEC7A, TMEM59, CACNG6, SLC46A2, PACSIN1, HDAC8, CADM1, PARD6B, NLN, PCDH11Y, ASPSCR1, OSBPL6, GPR63, PRKD2, ULBP3, FAM129A, CD244, SIGLEC1, TRIM4, INO80B, SLC39A8, WWP1, CCDC8, SDCBP2, CYSTM1, TRPV6, UPF3A, WNT5B, ABCG8, EHD4, SPTBN4, OR51E2, CXCL16, SLC26A1, TSPYL2, SLC38A1, TAOK3, RAB3GAP2, PNN, RHBG, TTYH1, SEMA4A, PIGU, RHOJ, DEF6, EPB41L1, FNDC4, GAREM1, DOCK5, C10orf54, AKTIP, HN1L, LIN7B, SLC28A3, SMURF2, PLEKHA2, NTN4, TRPV4, IFT122, VEZT, ETNK1, LGR6, PCDH9, SLC24A3, CAPN10, GBA2, SYTL2, MAGEE1, ANKH, PCDH18, GPAM, TMEM8A, SRA1, GOPC, RANGRF, MYO10, CD209, ABCB6, SLC40A1, TNFRSF12A, TREM1, MMP25, PARD6A, ACKR4, NRN1, CD320, ADAP2, IL1RAP, CD93, SLC52A3, ANO2, RTN4, NECTIN3, GPHN, CD163L1, DLL4, PDGFC, DUOX2, DUOX1, IL17RB, PLSCR4, CDC42SE2, INPP5E, CDC42SE1, SERINC1, AGPAT3, RASSF1, KCNIP2, GPR27, TNFRSF19, TM7SF3, HOMER3, LMBRD1, LIN7C, TDP1, EXOC1, PARVA, PAG1, PAK1IP1, PAQR5, STAB1, VNN3, SPHK1, CELSR3, ERAP1, FMN2, FAM120A, GDE1, GPRC5B, FLRT3, FLRT1, CRIM1, MPP6, VAPA, MARK1, CNTN3, STIM2, FNIP2, PCDH10, ATXN10, CTSZ, GABBR1, CTNNAL1, SLC9A2, TJP2, DNAJB4, KL, ADD3, EPHA6, SLC23A2, TES, SLC2A6, LIMA1, ASIC3, PCYOX1, SLC7A8, BAIAP2L1, ATP6V1H, SLCO3A1, ZDHHC2, LNPEP, PLXNA1, KCNG1, GPR160, CDH22, ENPP5, LAMP5, CDC42EP3, ADAM21, ACSL6, VAV3, ITGA11, PRND, RAB22A, NRXN1, RAB23, MTUS1, FZD4, SLC7A7, MYO6, COL17A1, PCDHGC3, PCDHA12, SLC6A14, RPH3AL, STUB1, PROCR, NSFL1C, FLVCR2, MACF1, EXOC7, SLC7A11, THSD7A, ERVW-1, LAMP3, TRPC6, COLQ, AKT3, KCNK6, RASD1, TNFSF13B, SIGLEC7, ITM2B, ATP11B, NISCH, EPB41L3, STXBP5L, SLC27A6, CRYL1, SAMHD1, PKP3, L3MBTL1, TLN1, TCAF1, DAAM1, PLXND1, IRS2, GPSM3, PCDHB9, PCDHB14, PCDHA9, PCDHA13, PCDHA1, HRH3, TRPV2, CDC42BPB, SNX9, LYVE1, HCFC2, F11R, GPC6, WNT6, MRPL42, XRCC6BP1, SLC30A1, TNFRSF11A, SLC4A4, ENPP4, LOC440434

GO:0005887

CC

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

ESYT2, SLC22A23, TMEM150B, TMEM150C, FXYD1, KCNK1, TLR4, GRM8, TNFRSF11B, SLC33A1, CLDN4, PLPP1, PLPP3, ENPP3, KCNK3, PRRG1, TNFSF11, TNFRSF10C, TSPAN4, EREG, PLXNB2, DCLK1, NPC1, MUSK, PLSCR1, SLC22A1, GRM6, GPR37, SLC16A6, SLC16A3, SLC31A1, SLC31A2, ABCC5, TLR3, CLDN3, FLRT2, AQP9, ATP8B1, TSPAN6, TYROBP, HS6ST1, ADCY3, FZD6, LY75, GPR137B, PLXNC1, ADCY9, TLR5, TLR2, TSPAN2, SLC16A7, SLC19A2, RAMP1, RAMP3, PLXNA2, ADAM23, GPR32, LGR5, GPC4, TNFRSF21, SLC22A3, CEACAM4, GABBR2, TM7SF2, SLC22A5, BEST1, AQP8, SLCO2B1, CSPG5, SLC25A14, MPZL1, ABCA1, SLC2A10, ECEL1, CLDN1, TSPAN13, TSPAN12, FADS2, CLPTM1, LDLR, TGFA, TNF, HLA-DRA, HLA-DQA2, HLA-DQA1, TFRC, OPN1SW, NTRK1, CYBB, SLC4A2, GYPC, APP, ITGB3, SLC25A5, ICAM1, INSR, ITGAV, CSF1R, ADRB2, IGF1R, NGFR, CHRM2, CD55, MME, PTPRC, MET, MFI2, ADRB1, CD48, LCT, PTPRF, CD28, GHR, SLC2A1, SLC2A3, CHRNB1, LAMP1, FGFR1, IGF2R, SLC25A4, GP1BB, ADRB3, SELL, CD99, DRD2, SLC2A4, IL1R1, PVR, IFNGR1, FOLR1, CD46, CD1D, MUC1, CD44, PDGFRA, EPCAM, ATP2A2, CD36, TMEM11, IFNAR1, GJA1, NPR3, CR1, ADRA2B, SDC1, TSPAN8, EPOR, CD58, CD53, FUT1, ATP2B1, HLA-DPA1, CD33, CHRM3, TNFRSF1B, NPR2, EFNA1, MAL, FPR1, CNR1, C5AR1, FGFR2, ERBB3, CD9, ENPP1, SLC2A5, LHCGR, MRC1, PTPRB, PTPRD, PTPRG, TNFSF4, ATP2B4, FSHR, IL4R, CXCR2, FPR2, ADRA1D, EDNRA, PTAFR, F2R, FAS, NPY1R, KLRC1, CD27, ACVR2A, STOM, HTR2C, PTPRM, TNFRSF8, ADORA2B, EPHA3, EPHB2, LTK, CD40LG, CNGA1, CD6, MIP, TM4SF1, AVPR2, SLC6A1, ADORA1, AGTR1, OXTR, SSTR1, GNRHR, SDC4, SLC6A6, GABRA5, CCKBR, GPR183, ABCC1, EVI2B, HTR7, GPC1, PHB, SSTR5, ADRA1A, HRH1, ADRA1B, PTGER4, TIE1, BSG, FLT4, GJA5, ACVR1B, LTBR, SCNN1A, IFNGR2, PMEL, OPRL1, AQP2, CD200, SLC19A1, ADCYAP1R1, HTR2B, TSPAN7, LIFR, SLC1A4, PTGFR, PTGER3, PTGER2, KIR3DL2, SLC6A8, MTNR1A, NPBWR1, GLRB, CD151, IFNAR2, SLC1A6, CD97, TRPC1, NPY2R, PTH2R, SLC11A1, SLC11A2, MTNR1B, PSEN1, PSEN2, AGTR2, MMP14, SLC26A2, TNFSF10, BCAM, SCNN1G, MMP15, MMP16, BCAP31, CAV2, CLCN4, CLCN5, CLCNKA, CLCNKB, PLXNA3, HNRNPM, SLC7A2, EFNA4, EFNB2, EPHA5, EPHB4, EPHB1, EPHA4, SLC12A2, F2RL1, JAM2, FXYD4, CD81, TSPAN5, VAMP2, CXADR, ADAM8, OLR1, SLC35A1, JAG1, ADAM17, HLA-DRB3, SLC7A9, PKD1, ATP2C1, MPP1, SLC25A3, IL9R, CD83, SLC7A5, MC2R, ROR1, NRG1, TEK, GUCY2D, CAV1, TGFBR3, PLAUR, NOTCH2, ACVR1, CD164, SLC18A2, TYRO3, PCDH1, DDR1, SLC20A2, CD47, KCNA1, SMAGP, BST2, MERTK, GRIN2A, LRMP, PTPRJ, TSPAN31, PTGDR, PTK7, SLC14A1, SLC39A6, TCIRG1, TRPC3, PKD2, LAPTM5, ACVR2B, ALCAM, ENPP2, BMPR2, SELPLG, ADGRE1, GPR176, CAPRIN1, KCNJ12, FAT1, ITPR3, KCNJ11, SSPN, GRM3, GPNMB, SLMAP, CLCA4, SLC39A14, EBP, PRKD1, NECTIN1, PTPRK, P2RY14, TLR1, MMD, SLC1A5, NPY5R, SCN9A, ZYX, ADRM1, SLC15A2, ASIC2, LY6E, SGCB, NKG7, NTRK2, AMHR2, PTPRO, MICA, SLC4A8, HFE, ATP13A5, FAM26F, STEAP4, TENM4, SLC18B1, SLC39A4, CSPG4, KIAA1324, SLCO4C1, SLC16A12, BTN2A1, MAEA, PLPPR4, TMEM150A, SLCO6A1, KTN1, TRABD2A, CD163, SGMS1, SLC26A11, PDPN, APCDD1, NLGN4X, BEST3, NLGN1, MFSD2A, GOLM1, PLPP5, TRPV1, GPRC5A, SEMA6D, TSPAN14, SGMS2, SLC35G2, LRRC8C, SLC16A10, SCARB1, FRS2, SLC20A1, SLC38A5, APH1B, STAB2, SLC5A11, CLEC2B, AQP3, SLC7A6, SORL1, HAS2, NRCAM, HPS1, SLC5A5, SLCO2A1, TNFRSF25, KISS1R, APH1A, PERP, PLPPR2, VSIG2, DCBLD2, HHIP, TSPAN18, KCNK17, CSF3R, HBEGF, MUC4, S1PR3, GPER1, P2RX4, SIGMAR1, TM9SF2, SLC29A1, SYT11, TM2D1, LGR4, C1QTNF1, CADM1, SLC39A8, PCDHAC1, TRPV6, OPN3, SLC26A1, SEMA6A, SLC38A1, RHBG, TMEM245, SEMA6B, ATP13A3, CALHM2, ADGRL3, SLC28A3, KCNK12, TRPV4, PLGRKT, LGR6, SLC24A3, ANKH, TMEM8A, SLC40A1, ACKR4, IL1RAP, ATP13A2, SLC52A3, GPRC5C, NECTIN3, IL17RB, PAG1, STAB1, FLRT3, FLRT1, TENM3, GABBR1, KL, EPHA6, SLC23A2, SLC2A6, ASIC3, SLC7A8, SLCO3A1, ZDHHC2, LNPEP, PLXNA1, SLC25A13, NAGPA, PILRB, PILRA, NRXN1, SLC39A10, FZD4, SLC7A7, COL17A1, PCDHA7, PCDHA6, PCDHA4, SLC6A14, PROCR, TFR2, GPR34, SLC7A11, TRPC6, RCE1, SIGLEC7, CNPY2, PLXND1, PCDHB3, PCDHA8, PCDHA5, PCDHA3, PCDHA2, PCDHA11, PCDHA10, PCDHA1, PCDHAC2, HRH3, MMP24, TRPV2, LYVE1, GPC6, ADGRG1, HS3ST3B1, TNFRSF11A, SLC4A4

GO:0005889

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hydrogen:potassium-exchanging ATPase complex

A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present.

GM2A, ATP12A

GO:0005890

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sodium:potassium-exchanging ATPase complex

Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.

FXYD1, ATP1B1, ATP1A2, ATP1B3

GO:0005891

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voltage-gated calcium channel complex

A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.

CACNA1G, CACNB3, CACNA2D1, PDE4D, CACNA1C, CACNA1E, CACNG8, CACNG6

GO:0005892

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acetylcholine-gated channel complex

A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.

CHRNB1, CHRNA5, CHRNA7, STXBP5

GO:0005895

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interleukin-5 receptor complex

A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3.

SDCBP

GO:0005896

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interleukin-6 receptor complex

A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130.

IL6, IL6R, IL6ST

GO:0005899

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insulin receptor complex

A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.

INSR, IRS1, SORBS1

GO:0005900

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oncostatin-M receptor complex

A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta.

IL6ST, OSMR

GO:0005901

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caveola

A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.

JAK2, LRP6, FLOT1, ATP1B1, INSR, HMOX1, SLC2A1, SELE, ATP2B4, F2R, MAPK3, MAPK1, NOS3, PTGS2, IRS1, BMPR1A, TGFBR2, ADCYAP1R1, ATP1A2, CAV2, EFNA5, ATP1B3, CDH13, CDH15, CAV1, LIPE, KCNMA1, AKAP6, CLN3, PTCH1, BMPR2, PTGIS, PTRF, SPRED1, BVES, KIF18A, SCARB1, PRKCDBP, DLC1, RANGRF, HDAC6

GO:0005902

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microvillus

Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.

MYO1G, MYO1C, CA2, TGFB1, PDGFA, CNP, EZR, VCAM1, ATP6V1B2, OXTR, RDX, CRB1, TEK, HYAL2, IQGAP2, ANGPT1, FSCN1, AOC3, SLC27A4, DCXR, CD302, EXOC4, BBS2, KIF13B, FMN2, MYO6

GO:0005903

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brush border

The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

MYO1C, CLIC1, ACTN4, FLNB, DAB1, MYO1D, MME, ACTN1, EZR, MYH9, MYL6, ACTR3, EPS8, MYO1E, RALGDS, ITPR3, PLS1, DCXR, CDHR2, ADD3, LIMA1

GO:0005905

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clathrin-coated pit

A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.

LDLR, TFRC, TF, APP, HSPD1, SLC2A4, SELE, EPS15, AP1S2, AP1S1, DAB2, VLDLR, LRP2, OCRL, TNK2, FCHO2, PICALM, CTTN, ITSN1, AAK1, LRP10, CEMIP, REPS1, FNBP1, SH3BP4, MYO6, AP4S1

GO:0005911

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cell-cell junction

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

SNAP23, KRIT1, CASK, PDZD2, NPHP1, FLRT2, ACTN4, CTNND1, WDR1, FLOT1, PLEKHG5, APP, KRT8, ANXA2, ITGA5, KIT, SLC2A1, ACTN1, JUP, VAV1, CDH2, CD53, FLNA, PIK3R1, PTPRM, CORO1A, AKT1, CDH5, CTNNA1, CTNNB1, MAP2K2, CSK, LIMS1, CDC42, ACTR3, PPP1CA, GRB2, CXADR, ADAM17, TEK, PRKCD, PCDH1, TWF1, PTPRJ, DLG1, MYO1E, TIAM1, STX3, PTK7, ILK, PKD2, BMPR2, DSG2, FAT1, PRKD1, PTPRK, OCLN, FSCN1, PDZD11, COL13A1, CDC42BPA, SV2A, SDCCAG8, IQGAP3, AHI1, PARD3, FRS2, AQP3, AJUBA, MAGI1, MYADM, PKP4, CDCA3, PKP2, TMEM47, CADM1, PNN, C10orf54, ECT2, LIN7B, ADGRL3, PDLIM7, LIN7C, FLRT3, FLRT1, ADD3, LIMD1, MYH2, HEG1, FZD4, COL17A1, PIKFYVE, EPB41L3, PKP3, TLN1, CDC42BPB, F11R

GO:0005912

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adherens junction

A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.

SDCBP, PLPP3, NPHP1, CTNNA2, CDH5, CTNNB1, NF2, NOTCH1, EFNA5, CXADR, JAG1, TNK2, MYO1E, NECTIN1, PTPRK, PIANP, AHI1, SHROOM3, AJUBA, MAGI1, FAM129B, PKP2, TMEM47, TBCD, WNK3, SPTBN4, TRPV4, VEZT, LIMD1

GO:0005913

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cell-cell adherens junction

An adherens junction which connects a cell to another cell.

ESYT2, PDLIM1, CLIC1, SDCBP, NOP56, DDX3X, CCS, SMAD7, PPL, EXOC3, CTNND1, FLNB, IDH1, FLOT1, RSL1D1, CCNB2, VAPB, LYPLA2, LDHA, EGFR, ALDOA, ANXA1, ITGB1, KRT18, ENO1, ANXA2, PFN1, LYN, SLC3A2, HSP90AB1, HSPA1A, HSPA1B, HSPA5, EEF2, PKM, JUP, PVR, EZR, RPS2, CDH2, CAST, FLNA, PCMT1, PAICS, ITGA6, APC, DNAJB1, S100P, CTNNA2, PTPRM, EEF1D, PRDX6, OXTR, YWHAB, SFN, S100A11, CTNNA1, CTNNB1, RDX, MYH9, BSG, TAGLN2, CAPG, EIF2S3, CD200, TMPO, TMPO, EPS15, RANBP1, RANGAP1, CRKL, IQGAP1, CAPZB, RPL29, CSNK1D, RPL34, FASN, NUMB, MRE11A, EMD, RPL14, CCT8, CAPZA1, ARFIP1, IST1, RARS, EIF5, RPL15, YWHAE, RPL7A, RPL23A, RAB1A, RPS26, YWHAZ, RACK1, HIST1H3D, RPL24, HDLBP, SPTBN1, DSC2, CALD1, PRDX1, TJP1, GOLGA2, AHNAK, SMAGP, TWF1, DLG1, PAK2, PICALM, SNX1, SHROOM2, CKAP5, DAG1, CTTN, TRIM25, SEPT2, STK38, NECTIN1, PCBP1, CNN3, MAPRE1, RAB11B, ZYX, SEPT7, PKN2, DBN1, FSCN1, LRRFIP1, COBLL1, FNBP1L, ARHGEF16, TWF2, LARP1, MPRIP, GIGYF2, BZW1, DHX29, PHLDB2, KTN1, ERC1, ABI1, ARHGAP18, SERBP1, GPRC5A, STXBP6, KIAA1524, DLG5, ZC3H15, PPP1R13L, ATXN2L, H1FX, NDRG1, GCN1, EFHD2, PDLIM5, SCYL1, FMNL2, FAM129B, PKP2, CORO1B, SORBS1, CADM1, EHD4, CHMP4B, EPB41L1, RTN4, NECTIN3, ANLN, DIAPH3, PARVA, ARGLU1, VAPA, TJP2, TES, LIMA1, BAIAP2L1, PUF60, ASAP1, MKL2, MYO6, MACF1, RUVBL1, SSX2IP, SH3GLB1, PKP3, TLN1, PPME1, SNX9, SNX5, F11R, STK24, BZW2, WASF2

GO:0005915

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zonula adherens

A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.

CTNND1, JUP, CTNNA1, SORBS1, CAMSAP3

GO:0005916

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fascia adherens

A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.

ACTN1, JUP, DSP, GJA1, DES, CDH2, CTNNB1

GO:0005921

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gap junction

A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.

GJA1, CALB2, MIP, GJA5, GJC1, TJP1, DBN1, PANX2, PANX1

GO:0005922

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connexin complex

An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.

GJA1, GJA5, GJC1

GO:0005923

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bicellular tight junction

An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.

CCDC85C, CLDN4, NPHP1, CLDN3, CLDN1, CDK4, EPCAM, APC, CDH5, CTNNB1, TGFBR1, ADCYAP1R1, PRKCI, JAM2, RAP2B, CXADR, PMP22, TJP1, ANK3, DLG1, SHROOM2, OCLN, AMOT, TJAP1, NHS, MTDH, MAGI2, AMOTL1, MPP5, BVES, INADL, PARD3, SYMPK, ARHGEF2, MARVELD3, MAGI1, TBCD, JAM3, PARD6B, WNK3, EPB41L4B, ECT2, LIN7B, PARD6A, ASH1L, LIN7C, VAPA, FRMD4A, TJP2, F11R

GO:0005924

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cell-substrate adherens junction

An adherens junction which connects a cell to the extracellular matrix.

SORBS1

GO:0005925

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focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

PDLIM1, SNAP23, SDCBP, ADAM10, NRP1, TSPAN4, CASK, PPP1R12A, ARPC2, ARPC3, ZNF185, CAPN5, FLRT2, TGFB1I1, ACTN4, PIP5K1C, SORBS3, LPXN, FLNB, FLOT1, SORBS2, MPZL1, EGFR, PLAU, KRAS, ANXA1, HSPB1, SLC4A2, ITGB3, ICAM1, RPLP1, RPLP2, RPLP0, ITGB1, NPM1, ITGAV, P4HB, PFN1, ANXA6, MME, PTPRC, ITGA5, VIM, RPS17, ANXA5, PDGFRB, HSPA1A, HSPA1B, RRAS, HSPA5, RALA, IGF2R, ACTN1, LCP1, PRKAR2A, CD99, HSP90B1, JUP, PVR, RAC2, EZR, CD46, RPS2, CD44, HMGA1, ITGA2, GJA1, ITGB5, RPL7, SDC1, CDH2, CSRP1, FLNA, CD9, TGM2, ITGA6, PPIB, JAK1, CFL1, TNC, ITGA3, MAPK3, DPP4, CALR, MAPK1, LAP3, MARCKS, RPL12, PDIA3, CCND3, S100A7, SDC4, YWHAB, GRK5, CTNNA1, CTNNB1, RDX, RPL22, MYH9, ACTN2, BSG, MAP2K2, RPL4, PPP1CC, RPL13A, MCAM, RPL5, RPS9, RPS5, RPS10, IQGAP1, LIMS1, CD151, CD97, NUMB, MMP14, GDI2, CAV2, CNN1, EFNB2, CDH13, CD81, ACTB, CDC42, ACTR3, ACTR2, RPS3A, RPL27, RPL37A, RHOA, B2M, RRAS2, RPS7, PPP1CB, RPS8, RPS16, YWHAE, RPS14, RPS18, RPS13, RPS11, RPL7A, RHOB, GNB2, RPL30, RPL31, RPL10A, PPIA, RAC1, YWHAZ, RPL38, ACTG1, TPM4, ACTC1, ADAM17, ARF1, RPL19, DAB2, HSPG2, KIF23, MAP2K1, TEK, DST, GNA12, CAV1, PLAUR, PTK2, RPL18, AHNAK, NEXN, TWF1, G3BP1, PTK7, ILK, SNTB2, ADAM9, FHL1, ALCAM, SNTB1, DAG1, ARHGEF7, GIT2, CTTN, FLNC, NEDD9, FAT1, MDC1, KIF22, CNN3, DIXDC1, TRIP6, ZYX, CSRP2, ARHGAP31, DCAF6, TNS2, NHS, CSPG4, MPRIP, RHOU, CYFIP1, ARHGAP22, PHLDB2, PRUNE, ARHGAP24, ENAH, PDCD6IP, FBLIM1, PALLD, SYNE2, STARD8, ARHGEF2, LPP, TADA1, AJUBA, PDLIM2, DOCK7, DLC1, CHP1, ZFYVE21, AIF1L, FERMT1, CORO1B, SORBS1, SPRY4, TRIOBP, TRPV4, TNS1, NOX4, CASS4, PDLIM7, PARVA, AATF, EHD3, FLRT3, FLRT1, HACD3, TES, LIMD1, LAMTOR3, LIMA1, EVL, ITGA11, RAB21, CORO1C, SYNPO2, ARHGAP26, PROCR, GIT1, REXO2, TLN1, HYOU1

GO:0005929

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cilium

A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.

SNTN, AURKA, ADCY3, CEP104, TULP3, OFD1, DNAL4, TUBB4A, DLD, GLI3, PKM, CCT8, NEK4, EVC, PKD1, CAV1, DNAH14, PKD2, TTLL9, CFAP157, DNAH12, BBS12, NPHP3, NEK8, PKHD1L1, DNAH10, AHI1, BBS10, TTC8, TEKT1, CLUAP1, IFT43, TMEM80, IFT74, IFT27, TRPV4, IFT122, TMEM138, IFT46, TULP4, WDR35, DNAI1, INVS, ATP6V1D

GO:0005930

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axoneme

The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.

DNALI1, TULP3, GLI2, GLI3, MAPT, MAK, CENPF, SEPT2, SEPT7, ARMC4, RSPH4A, CCDC103, BBS7, CFAP46, PIK3C3, MNS1, BBS1, DYNC2LI1, DNAH5, KIFAP3, WDR34, AK8, DRC1, PIK3R4, MAP1LC3B, INPP5E, DNAH9, SPATA7, WDR35, DCDC2

GO:0005938

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cell cortex

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

AXIN1, COBL, FLNB, USP2, FGA, FGB, FGG, ANXA2, PFN1, FGFR2, CTGF, MARCKS, AKT2, CTNNB1, SNCA, PSEN2, GYS2, RHOA, GPSM2, DST, CAV1, COL10A1, PTK2, AKAP13, EPS8, MYO9B, ARHGEF7, CTTN, NEDD9, ITPR2, MELK, SEPT2, PRKD1, TRIP10, DBN1, FAM110C, FNBP1L, FRY, AGTRAP, C2CD5, CD302, PARD3, FBLIM1, FNBP1, NDFIP1, PARD6B, TLE6, MYO10, PARD6A, FMN2, CLIC5, BIN2, ADD3, MKLN1, MYO6, PLA2G4C

GO:0005940

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septin ring

A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.

SEPT6

GO:0005942

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phosphatidylinositol 3-kinase complex

A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.

PIK3CD, PIK3C2A, PIK3R1, PIK3CA, PIK3CB, PIK3C3

GO:0005943

CC

phosphatidylinositol 3-kinase complex, class IA

A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.

PIK3R1, PIK3CA

GO:0005944

CC

phosphatidylinositol 3-kinase complex, class IB

A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.

PIK3CG

GO:0005945

CC

6-phosphofructokinase complex

A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known.

PFKL

GO:0005947

CC

mitochondrial alpha-ketoglutarate dehydrogenase complex

Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity.

DBT, BCKDHA, BCKDHB

GO:0005952

CC

cAMP-dependent protein kinase complex

An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.

PRKAR1A, PRKAR2A, PRKACA, PRKAR2B

GO:0005953

CC

CAAX-protein geranylgeranyltransferase complex

A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.

PGGT1B

GO:0005955

CC

calcineurin complex

A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.

PPP3CA, ITPR1

GO:0005958

CC

DNA-dependent protein kinase-DNA ligase 4 complex

A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV.

PRKDC, XRCC4, XRCC6BP1

GO:0005960

CC

glycine cleavage complex

A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.

GCSH

GO:0005964

CC

phosphorylase kinase complex

An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.

PHKA2, PHKA1

GO:0005967

CC

mitochondrial pyruvate dehydrogenase complex

Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.

DLAT, PDK1

GO:0005968

CC

Rab-protein geranylgeranyltransferase complex

A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.

CHM, CHML, RABGGTB

GO:0005969

CC

serine-pyruvate aminotransferase complex

An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate.

EEA1

GO:0005971

CC

ribonucleoside-diphosphate reductase complex

An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.

RRM1, RRM2

GO:0008021

CC

synaptic vesicle

A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

TOR1A, SYNGR3, STX11, SNAPIN, TH, MME, LAMP1, SYN1, RAB3B, RAB5A, SYT1, MT3, STX2, SNCA, VDAC2, PPT1, CLCN3, SNAP25, ATP6V0D1, VAMP2, DLG4, CDK16, APBA1, SLC18A2, STX4, GRIN2A, STX3, CLN3, MTMR2, SEPT6, RAB11B, STXBP5, SV2A, SV2B, DMXL2, SYT11, TRIM9, NDEL1, MFF, SLC40A1, VTI1B, WDR7, SNCAIP

GO:0008023

CC

transcription elongation factor complex

Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

ELL2, IKBKAP, ELOF1, ICE2, ELP4, EAF1, ELP3, AFF4, NUFIP1, TTF2

GO:0008024

CC

cyclin/CDK positive transcription elongation factor complex

A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.

CCNT1, CCNT2, RB1

GO:0008043

CC

intracellular ferritin complex

A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.

FTL, FTH1

GO:0008074

CC

guanylate cyclase complex, soluble

Complex that possesses guanylate cyclase activity and is not bound to a membrane.

NPR2, GUCY2D

GO:0008076

CC

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

KCNK1, DPP6, SNAP25, CALM2, VAMP2, DLG4, KCNA1, KCNMA1, KCNH2, KCNC3, CTTN, KCNJ11, KCNG3, KCNV2, KCNIP2, KCNG1, KCNK6

GO:0008091

CC

spectrin

Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.

SPTBN1, SPTBN4

GO:0008180

CC

COP9 signalosome

A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.

FLOT1, HSP90AB1, HSPA5, HSPA6, TMOD1, HSPA1L, MYH9, GRB2, DYNLL1, AMOT, COPS6, AMOTL1, DOCK7, COPS8, COPS7B

GO:0008250

CC

oligosaccharyltransferase complex

A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.

DDOST, STT3A, DAD1, STT3B, OSTC

GO:0008274

CC

gamma-tubulin ring complex

A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule.

BRCA1, MZT1, MZT2A

GO:0008275

CC

gamma-tubulin small complex

A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex.

TUBGCP3, CENPJ

GO:0008278

CC

cohesin complex

A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).

RAD21, WAPL, CDCA5, SMC3

GO:0008280

CC

cohesin core heterodimer

The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes.

SMC1A, SMC3

GO:0008282

CC

ATP-sensitive potassium channel complex

A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.

KCNJ11

GO:0008290

CC

F-actin capping protein complex

A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.

CAPG, CAPZB, CAPZA1, MTPN

GO:0008305

CC

integrin complex

A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.

ITGA10, ITGB3, ITGB2, ITGB1, ITGAV, ITGA5, ITGAM, ITGB4, ITGA2, ITGAX, ITGA3, ITGB8, MYH9, ITGAE, ITGA9, ITGA11

GO:0008328

CC

ionotropic glutamate receptor complex

A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.

DLG4, DLG1

GO:0008352

CC

katanin complex

A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).

KATNB1

GO:0008385

CC

IkappaB kinase complex

A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

MAP3K13, MAP3K7, ERC1, PYCARD

GO:0008537

CC

proteasome activator complex

A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.

PSME3

GO:0008540

CC

proteasome regulatory particle, base subcomplex

The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

PSMD10, PSMC3, PSMC2, PSMC4, PSMC1, PSMC6, PSMD2

GO:0008541

CC

proteasome regulatory particle, lid subcomplex

The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.

PSMD11, PSMD12, PSMD3, SHFM1

GO:0008622

CC

epsilon DNA polymerase complex

A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.

POLE2, POLE, POLE4, POLE3, CHRAC1

GO:0008623

CC

CHRAC

An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair.

CHRAC1, BAZ1A

GO:0009279

CC

cell outer membrane

A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

SLC11A1, DAG1

GO:0009328

CC

phenylalanine-tRNA ligase complex

An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe).

FARSA

GO:0009330

CC

DNA topoisomerase complex (ATP-hydrolyzing)

Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.

TOP2A

GO:0009331

CC

glycerol-3-phosphate dehydrogenase complex

An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate.

GPD2

GO:0009353

CC

mitochondrial oxoglutarate dehydrogenase complex

A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus.

MRPS36

GO:0009360

CC

DNA polymerase III complex

The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork.

CRCP

GO:0009368

CC

endopeptidase Clp complex

A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form.

CLPX, CLPP

GO:0009841

CC

mitochondrial endopeptidase Clp complex

A Clp endopeptidase complex located in the mitochondrion.

CLPX

GO:0009897

CC

external side of plasma membrane

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

IGLL5, TLR4, SEMA7A, GPC4, ABCA1, CLPTM1, GSR, ADA, LDLR, TNF, CD4, FGA, FGB, FGG, TFRC, CD74, SERPINA5, IL6, ICAM1, ITGB1, ITGAV, P4HB, THBS1, PTPRC, ITGA5, ANXA5, KIT, CD28, LAMP1, ACE, NCAM1, SELL, SLC2A4, B4GALT1, CD36, IL7R, ITGA2, LAG3, SDC1, VCAM1, CD33, S1PR1, CD9, ITGA6, FAS, ITGA3, CD27, CALR, CD40LG, CDH5, CHRNA7, BMPR1A, TGFBR2, ITGAE, IL6ST, IL12RB1, ECE1, MCAM, CXCL12, BCAM, SCNN1G, CLCN3, EPHA5, CDH13, ANTXR2, B2M, CD83, IL1RL1, NRG1, TGFBR3, MFGE8, ALCAM, ADGRE1, SPA17, HFE, AMOT, CD276, VTCN1, RTN4RL1, PDPN, ADGRA3, SCUBE1, NLGN1, TRPV1, LILRB1, STAB2, NRCAM, MAP3K5, CD244, HEG1, TFR2, TNFRSF11A

GO:0009898

CC

cytoplasmic side of plasma membrane

The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

TH, KIT, G6PD, JUP, GM2A, ATP2B1, PTPN4, MAP2K2, RGS2, GEM, PTEN, DLG1, LDLRAP1, PTP4A1, PKP4, ASPSCR1, CHMP4B, RAB21, PTPN22

GO:0009925

CC

basal plasma membrane

The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

MYO1C, CLDN4, TF, MET, ITGA6, EPS15, TEK, DST, ANK3, PKD2, ITGA9, BMPR2, LDLRAP1, MUC20, SLC23A2

GO:0009986

CC

cell surface

The external part of the cell wall and/or plasma membrane.

TLR4, ADAM10, NRP1, PLXNB2, CAPN5, NRDC, TYROBP, FZD6, GREM1, TLR2, SRPX2, RAMP1, RAMP3, SDC3, HMMR, ENTPD6, VAMP4, LRP6, CLSTN1, CSPG5, MPZL1, BMP10, GOT2, EGFR, PLG, PLAU, PLAT, ADA, PDGFB, LDLR, TGFA, TGFB1, TNF, HLA-B, HLA-DRA, CRYAB, APOA1, FGA, FGB, FGG, APOH, AMBP, TFRC, TF, ANXA1, PDGFA, PRNP, CD74, NTRK1, APP, ITGB3, ITGB2, ICAM1, ITGB1, ITGAV, LPL, CSF1R, ANXA2, HSP90AA1, THBS1, NGFR, CD55, SLC3A2, HSP90AB1, PTPRC, MET, MFI2, ITGA5, IL6R, LGALS1, HMGB1, SPARC, ANXA4, PDGFRB, FURIN, TFPI, CD28, HSPD1, CLU, GHR, HSPA5, ITGAM, MBL2, RALA, DMD, IGF2R, BMP2, TDGF1, CFTR, NCAM1, PDIA4, HLA-E, MIF, CPM, IDE, IL1R1, PVR, FOLR1, AREG, CD46, VEGFA, CD1D, ARSB, TIMP2, CD44, ITGB4, EPCAM, PRLR, CD36, ITGA2, CR1, ITGB5, SDC1, PAM, CD58, VCAM1, CD53, HLA-DPA1, ITGAX, NT5E, C5AR1, FGFR2, BGN, FUT4, ENPP1, CA4, MRC1, ITGA6, TNFSF4, CXCR2, CD24, F2R, FAS, ITGA3, ITGB8, ACVR2A, DPP4, CALR, PCSK6, CD40LG, ERP29, PDIA3, HLA-A, HLA-F, SLC6A1, LRPAP1, SDC4, CDH5, SDC2, PHB, ACVR1B, TGFBR1, WNT5A, ADCYAP1R1, SLC1A3, SLC1A2, SLC1A4, NOTCH1, SLC11A2, PSEN1, MMP16, CLCN3, VAMP7, EPHA4, EMP2, SYNJ2BP, CXCR4, CXADR, ADAM8, ADAM17, PKD1, NDP, HNRNPU, TEK, TGFBR3, NOTCH2, C1QBP, KCNA1, BST2, KCNH2, STX4, CDH17, GRIN2A, HYAL2, PTPRJ, ANK3, SLC39A6, ADAM9, IQGAP2, BMPR2, DSG2, DIP2A, PTPRK, VAMP3, ADIPOQ, AOC3, MICB, MICA, ANO6, SFRP4, CSPG4, RTN4RL1, LRRC8A, SULF2, SULF1, SCUBE1, SCUBE3, NLGN4X, NLGN1, SFRP1, PCSK9, TSPAN14, CYP2W1, HM13, ADAMTS15, DEFB104A, SCARB1, GPR98, TNR, GHSR, KISS1R, SLC46A1, DCBLD2, HHIP, HBEGF, PHB2, ERP44, SLC46A2, ULBP2, WNT5B, CLSTN2, C10orf54, TMEM206, TRPV4, RC3H2, TNS1, ROBO2, APMAP, CD209, TNFRSF12A, CD93, PDGFC, IL17RB, CLDND1, GPRC5B, ADAMTS9, ADAMTS7, NRXN1, INTU, FZD4, PROCR, SLC7A11, TLN1, HILPDA, TRPV2, LIPG, WNT6

GO:0010008

CC

endosome membrane

The lipid bilayer surrounding an endosome.

VPS37C, TLR4, RHOD, GOLIM4, AP3D1, LEPROT, ATP6V0E1, TLR3, IRAK2, MAP3K7, SNX3, VPS4B, VPS26A, AP1G2, EGFR, LDLR, HLA-DQA2, HLA-DQA1, HLA-DQB1, TF, APOB, ERBB2, INSR, CD14, UBC, LAMP1, HLA-DOB, CD1D, HLA-DPA1, RAB5A, UBA1, MRC1, CD68, RAB7A, IRAK1, CLCN4, CLCN5, CLCN6, ANTXR2, UBE2D3, ATP6V0D1, RHOB, RPS27A, UBA52, CD164, TCIRG1, SNX1, GRB14, ACAP2, NCF4, TAB1, NTRK2, WDR44, WIPI1, PARM1, RABEPK, VPS52, TAB3, COMMD1, APPL2, VPS37A, TPCN2, RFFL, TBC1D5, ATP6V0A1, PMEPA1, TMBIM1, VPS35, SNX18, TM9SF2, NDFIP1, TMEM165, ABCB6, VTA1, CD320, EHD3, ANKFY1, VPS29, SUN2, LAMTOR3, TBK1, LAMP5, GGA2, GGA1, RAB22A, RAB23, ITM2B, PIKFYVE, LAMTOR2

GO:0010369

CC

chromocenter

A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure.

OIP5, CBX5, CBX1, FMR1, CDCA8, ESCO2, MBD6, AURKB, MBD5

GO:0010494

CC

cytoplasmic stress granule

A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.

FAM195B, DDX3X, PQBP1, STAU1, EIF2S1, EIF4E, ZFP36, TIA1, YBX1, G3BP1, CIRBP, CAPRIN1, PUM1, NUFIP2, LSM14A, PUM2, ATXN2L, KHSRP, RBPMS, FAM195A, RBM4, LIN28A, MBNL1

GO:0012505

CC

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

ACACB, PIP5K1B, PGRMC2, BCL2L11, PIP5K1C, TBC1D4, SLC2A10, TBC1D8, TBC1D3H, SLC2A4, ATP6V1B2, JAK1, JAK3, RAC3, TBC1D8B, GRTP1, TBC1D9B, TBC1D3C, NBEAL1, TBC1D9, RUFY3, LAPTM4B, TBC1D3, MPP5, RHEBL1, TBC1D15, PARD3, CYB5D2, DOCK2, NSMAF, USP6NL, MAL2, RUNDC1, EVI5L, ASPSCR1, MAP1LC3B, NRBP2, AIG1, CDC42EP3, NENF, TBC1D2B, RABGAP1

GO:0012506

CC

vesicle membrane

The lipid bilayer surrounding any membrane-bounded vesicle in the cell.

SYNJ1, ANXA4, SLC2A4, ACPP, ATP2A2, CLCN3, GRB2, ASPSCR1, ATP13A2, RAB21, PIKFYVE

GO:0012507

CC

ER to Golgi transport vesicle membrane

The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.

GOSR2, SEC22B, SEC24D, SEC31A, TGFA, HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, HLA-E, HLA-DRB4, FOLR1, AREG, HLA-G, HLA-DPA1, HLA-A, HLA-F, SREBF1, TMED10, SEC13, B2M, HLA-DRB3, SREBF2, TMED2, SEC23A, HLA-DRB5, MCFD2, VTI1B, SAR1B

GO:0012510

CC

trans-Golgi network transport vesicle membrane

The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell.

RASSF9

GO:0014069

CC

postsynaptic density

The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms an electron-dense disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases.

DLGAP1, ADAM10, AXIN1, LZTS3, DAB1, CRYAB, FYN, LYN, FBXO45, MAPT, BCR, DRD2, IFNGR1, SYN1, GAP43, MT3, ADORA1, NSF, MAP1B, EPHA4, NCS1, DLG4, ARF1, CDK5, FMR1, SOS1, GRIN2A, EPS8, DLG1, MAPK8IP2, MTMR2, PTCH1, CACNA1C, ITPR1, GRM3, CNN3, CPEB4, NSMF, ARC, CAMK2N1, MAGI2, HOMER1, MIB1, ABI1, NLGN4X, NLGN1, MINK1, NETO2, CACNG8, PDLIM5, ALS2, GPER1, PKP4, P2RX4, SIGMAR1, SYT11, LIN7B, GOPC, HOMER3, LIN7C, PSD3, CRIPT, IGSF9B, LZTS1, PCLO

GO:0014701

CC

junctional sarcoplasmic reticulum membrane

The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane.

AKAP6, RYR2

GO:0014704

CC

intercalated disc

A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.

OBSL1, ATP1B1, ITGB1, JUP, DSP, GJA1, DES, CDH2, CTNNA1, GJA5, GJC1, ATP1A2, HAMP, ANK2, DSC2, YWHAH, TJP1, ANK3, DLG1, AKAP6, CAMK2D, DSG2, KCNJ11, TMEM65, FGF13, PKP2, RANGRF

GO:0014731

CC

spectrin-associated cytoskeleton

The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane.

SPTBN1, ANK3, RHBG

GO:0015030

CC

Cajal body

A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.

XPO1, PRPF3, OIP5, ZPR1, SNRPC, CDK2, COIL, FMR1, NPAT, SART3, ICE2, DDX46, TRIM22, PRPF31, ISG20, EAF1, PHAX, SRRM2

GO:0015629

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actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

HAX1, WASL, BIN1, ABLIM1, CASK, PPP1R12A, FYB, ARPC2, ARPC3, ZNF185, SLC16A3, ARHGAP6, MTSS1, ACTN4, PPP1R12B, FLNB, STK17B, SORBS2, APBB3, ZBED1, ALDOA, APOB, FGR, LCP1, JUP, EZR, RAB5A, FLNA, CFL1, CTNNA2, TARS, MARCKS, LSP1, CTNNA1, MYH9, PGM1, SNCA, ABL2, IQGAP1, CAPZB, PSMB3, KNTC1, CAPZA1, DAPK1, SMTN, DSTN, ACTR3, ACTR2, ACTA2, ADAM17, CALD1, AHNAK, TWF1, MYO1E, IFIT5, MYO9B, NFATC2, IQGAP2, ZNF268, POU6F1, SEPT2, CNN3, TAF5, SEPT7, DBN1, FSCN1, CROCC, MPRIP, CENPQ, ARC, GAS2L3, PHC3, PALLD, TOPBP1, CORO2A, TTC17, PDLIM5, PAWR, PDLIM2, C9orf72, FGD4, FAM129B, NCAPG, AIF1L, NDC1, TRIOBP, MYOZ1, PARD6A, ANLN, PDLIM7, FMN2, CLIC5, CTTNBP2NL, MYOT, LIMA1, BAIAP2L1, CDC42EP3, INTS6, RAB22A, CORO1C, SYNPO2, STK38L, CCDC53, ORC6, MAD1L1, WASF2, IVNS1ABP

GO:0015630

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microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

CDC7, AURKA, PRC1, NUAK1, TACC1, OFD1, CCNB2, MFN2, TACC2, CRYAB, GAPDH, ESRRA, GTF2F2, MAPK3, MAPK1, PPP2R1A, CLIP1, AKT1, PRKCI, ACTR1B, IQGAP1, MCM2, PLK1, CCNA1, CDK16, CENPE, ID3, NUCB1, DST, CKAP5, MAP7, RBM39, KARS, MAPRE2, TAF1A, SEPT7, MAP7D1, MAST2, PSRC1, WAPL, CENPV, GAS2L3, CEP57, RELL1, KIF18A, THAP6, NUDCD2, CKAP2, NDRG1, KIFAP3, IFT43, MARK4, C12orf66, STRBP, CHP1, KIF2C, FEZ1, LYST, KATNB1, WDR11, USP44, ENKD1, PCIF1, EML4, SRA1, MID1IP1, RASSF1, HYPK, VAPA, MARK1, SPATA7, SLAIN2, SPAST, TPX2, TIMELESS, KNSTRN, KIF3A, F11R, TACC3

GO:0015934

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large ribosomal subunit

The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).

RPL13A, RBM3, MRPL30

GO:0015935

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small ribosomal subunit

The smaller of the two subunits of a ribosome.

RPS16, RPS18, RPS6, RPS25, RPS26, RPS27A, RPS21, RACK1

GO:0016010

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dystrophin-associated glycoprotein complex

A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.

KRT8, KRT19, DMD, SNTB2, SNTB1, DAG1, SSPN, SGCB, SGCD, FKRP, MAGEE1

GO:0016011

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dystroglycan complex

A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.

DAG1

GO:0016012

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sarcoglycan complex

A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.

SGCB, SGCD, SGCZ