| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0005712 | CC | chiasma | A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over. |
MLH1, PMS1, MLH3 |
GO:0005719 | CC | nuclear euchromatin | The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin. |
KLF4, JUN, H2AFZ, CREB1, HIST1H1C, CTNNB1, RBMX, HIST1H1A, CBX3, TRIM28, ALKBH1, NSMF, NR1H4, PPARGC1A, ASH2L, RUVBL2 |
GO:0005720 | CC | nuclear heterochromatin | A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. |
H2AFZ, HIST1H1E, TCP1, CBX5, ATRX, CBX1, SATB1, FOXC1, CBX3, TRIM28, KMT5C, SIRT2, EME1, UHRF2, UHRF1, MPHOSPH8 |
GO:0005721 | CC | pericentric heterochromatin | Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. |
H2AFY, DNMT1, CBX5, ATRX, CBX1, CENPC, KMT5C, HELLS, LRWD1, BAZ1B |
GO:0005726 | CC | perichromatin fibrils | Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts. |
TARDBP, NUFIP1 |
GO:0005730 | CC | nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
GTPBP10, MIF4GD, AGPS, MYO1C, IPO5, PLK4, BTN3A3, ZNF593, NOP56, NFIB, BHLHE40, CHD2, ENC1, CASK, XPO1, SMAD7, PLSCR1, CETN3, UBD, FANCG, CD3EAP, DHX15, PLRG1, ZNF207, ASNA1, SMARCA5, NUAK1, REV3L, CDC14B, DKC1, EDF1, DIAPH2, NBN, NOL3, N4BP1, ZPR1, H2AFY, PEX14, TULP3, DAB1, NPM3, UTP20, RSL1D1, FGF18, SRP72, IKBKAP, SNAPIN, SMC2, TACC2, PARN, NSA2, TDP2, POLR1A, MYC, ANG, CSTB, TP53, TYMS, KRT18, NPM1, CTSB, NFIC, SNRPA, HMOX1, PARP1, POLA1, MAP2, TOP1, TOP2A, ESRRA, CDK4, XRCC5, EZR, GCFC2, UBTF, DDX5, RPL7, ATF3, WT1, NCF2, FLNA, OSBP, DNAJB1, HMGB2, PTBP1, KDM5A, EEF1D, RPL12, CCND2, WEE1, NF2, RPL4, PPP1CC, POLR2I, COIL, CDKN1A, FEN1, CAPG, RPL13A, RGS2, SKIV2L2, PIK3CB, RPL35, CBX5, MKI67, NOP2, RPL5, RPL21, RPS9, RPS10, NRIP1, RPL34, CDK8, ARL4D, ACADVL, NUP153, MXI1, FXR1, NOVA1, SMARCA4, NEK2, HNRNPM, PLK1, TTC3, SUB1, BLM, TERF1, SNU13, EIF6, GEMIN4, NLRP5, SRP54, YPEL3, RPS3A, RPS7, PPP1CA, PPP1CB, RPS14, RPS13, RPS11, LSM6, RPL7A, RPL23A, RPS6, RPS25, RPS26, RPL10A, RPL11, RPS27A, GRB2, EEF1A1, PAFAH1B2, SRPK2, RAE1, PRKDC, ADARB1, RPL19, ZBED6, DAB2, RBM3, SLC25A3, GTF2B, MDM2, SPTBN1, XPC, EWSR1, TLE1, ZBTB16, EXOSC9, RAD51, FMR1, RPL18, C1QBP, PPID, SSRP1, NSUN2, TBL3, ILF2, ILF3, CHAF1A, SELENBP1, SRSF9, SRSF5, SKP2, SLC14A1, ORC1, TCOF1, TRA2A, PWP1, CUL2, EXOSC2, C1D, CIRBP, VEZF1, BOP1, EIF3A, RCN2, ITPR3, ITPR1, RRP1B, MORF4L2, SEPT2, SUZ12, EXOSC7, RRS1, ACOX1, NONO, RBBP5, ANKRD1, PUM3, ZFHX3, SEPT7, SNAPC1, MRPL23, IFI16, KNOP1, TSR1, CERKL, MIDN, CDCA8, SMUG1, NOM1, CENPW, RRP12, ZNF506, DNTTIP2, EXOSC6, RSPH4A, ATF7IP2, ARL6IP4, SPTY2D1, JMJD6, INO80C, ZC3H14, WDR74, C6orf89, KDM7A, RNF111, NOL8, ZNF771, MCM10, SETX, RBBP6, PCGF5, ZBTB33, MTDH, JAZF1, SPATA24, RPS19BP1, MINA, DHX40, KLHL7, DHX37, ZCCHC7, NIN, ZCCHC9, OXR1, AOPEP, ZNF655, KRI1, SPC24, INO80E, HJURP, PAPD5, NGDN, NEK11, WDR36, DDX54, HELQ, STK35, UTP15, SETD7, ZC3H15, PHLDA1, TRIM41, UBLCP1, TSEN15, PSPC1, PPM1E, ARNTL2, H1FX, RTF1, MRPS31, ANP32B, P3H4, KAT6A, DDX17, FGF13, EMG1, MED12, UTP4, EME1, ISG20, EXOSC8, CHCHD1, NUDT16, MBD6, S100A16, ZNF274, VMP1, CDCA7L, DDX27, SENP5, CDKN2AIPNL, ABHD14B, KIF20B, YPEL2, ERGIC2, USP28, FAM129B, CDC5L, MPHOSPH8, SCAF11, TXN2, EBNA1BP2, ARID3A, HAUS7, VRK1, RBM4B, MYBBP1A, LLPH, UTP23, FAM64A, DDX23, THUMPD3, GNL3, HIRIP3, ACAT2, RBM4, HINT2, NUSAP1, FANCD2, NIFK, MRO, INO80B, WDR12, DDX24, POLR1E, KATNBL1, USP44, DDX47, THAP2, DNTTIP1, TSPYL2, SENP3, OBFC1, NOL11, DDX31, AKTIP, ELP3, LIN28A, MEAF6, SAP30L, SP110, MKNK2, MYO10, EXOSC4, NOX4, MRPL40, EXOSC3, SNX15, BRWD1, MDN1, STAU2, DDX28, SPATS2L, DCAF13, GNL3L, SDAD1, THAP1, GPATCH2, PAK1IP1, LYAR, ZDHHC7, ING3, CDKN2AIP, GAR1, AATF, BCLAF1, CDK12, RRN3, FMN2, GPRC5B, IL37, DTL, GLTSCR2, THYN1, CRIPT, USP36, CHD7, KANSL3, DNAJB9, PARP2, NOL12, NUFIP1, HN1, MRTO4, PNMA3, PNMA2, TAOK2, PYCARD, PHTF1, NOL7, DIMT1, TIMELESS, WDR3, PA2G4, NIP7, PIN4, KDM2A, RCL1, DDX52, CRYL1, POLR3K, FCF1, SBDS, REXO2, ZNF330, NOC2L, RPL36, LAS1L, UTP18, SPIN1, STK24 |
GO:0005732 | CC | small nucleolar ribonucleoprotein complex | A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. |
NOP56, SNRPF, LSM6, SNRNP40, NAF1, NOP10, LSM7 |
GO:0005736 | CC | DNA-directed RNA polymerase I complex | RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. |
POLR1C, CD3EAP, POLR1A, POLR2E, POLR2K, POLR2L, POLR1E, ZNRD1, POLR1D |
GO:0005737 | CC | cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
UBA6, SH3PXD2B, FRMD3, PTPDC1, MEIOC, KIAA0922, TMEM189, CNOT1, CCDC42B, ASB14, GOLGA8A, C4orf47, BBIP1, MIF4GD, AHRR, FAM195B, NACA, DDX39A, PDLIM1, ACOT7, MYO1C, SNAP23, AIP, TLR4, APBB1, PSMD12, DFFA, HIP1, CLIC1, WWP2, CDC7, IPO5, SAP18, IGF2BP3, PIK3C2A, IFRD1, EXOC5, ELL2, BTN3A3, NR5A2, BIN1, KRIT1, SDCBP, NOP56, DDX3X, UBE2C, PDXK, SOCS2, SOCS3, SOCS6, ARHGAP33, DYNC1I1, CCS, ABLIM1, DNALI1, CHD1, ADAM10, ENC1, ITGB1BP1, MAP2K7, PDCD5, TNPO2, TNFSF11, MSTN, BACH1, IRF6, TAX1BP3, RGS12, CASK, TFEC, RAB29, PPP1R12A, AZIN1, HNRNPDL, XPO1, PDZD2, MAST4, PFAS, NACAD, SMAD7, KPNA5, ARPC2, AXIN1, SMAD9, UBD, PFDN6, ZNF185, FANCG, SIVA1, INPP4B, HMGB3, PPM1G, HDAC3, BIRC5, CD3EAP, TLR3, P4HA2, MAGEB4, CAPN5, NUPL2, CFLAR, SOCS1, CYP27B1, PER1, RGS5, DHX15, FLRT2, ARHGAP6, IRAK2, PSMD3, RBFOX2, SIAH2, SPINT2, DAPK3, TGFB1I1, AP5Z1, CTIF, MTSS1, MAP3K7, EEF1E1, RIPK2, PRPF3, PPIH, KLF4, OIP5, CACNA1G, RAD51C, FOXO3, SMAD6, AKAP10, SPRY1, SNAI2, PRC1, ZNF207, ASNA1, BUB1, ACTN4, SGTA, ENSA, C21orf2, AHCYL1, CD5L, ORC5, DHX16, SH3BP5, SOX15, PARK2, ADCY3, KIAA0513, SPAG9, KIF5C, NUAK1, TRAK2, LZTS3, OPA1, TBC1D4, NUPR1, GDF9, BRINP1, ACSL4, SNX3, RANBP6, GMDS, NMT2, BUB1B, TLR2, JAK2, PRMT3, SRPX2, LPXN, CTNND1, CDC14B, HIST1H2BK, PQBP1, DKC1, EIF5B, GAS7, EDF1, BRD4, PPP1R11, WDR1, AOC2, MFAP3L, OBSL1, TSC22D2, SOCS5, SIN3B, GADD45B, ZPR1, PDCD6, VPS4B, FLNB, ULK1, TULP3, PRPF40A, TACC1, MAF, ERN1, SRSF10, GMNN, BANF1, SKAP2, PRKRA, RPS6KA5, LYPLA1, ADAP1, UTP20, RP2, WDHD1, RAD51D, RNASEH2A, CDC123, PPP1R15A, CAPN15, POP7, PSMD10, IDH1, STAM2, TNFSF13, ALDH1L1, GABBR2, PAK3, ATP5H, SASH3, CLPX, SEC14L2, RNF8, ZFAND5, SRP72, DXO, RECQL4, URI1, ALDH1A2, TPPP, SLIT2, PLEKHG5, FARP2, LRIG2, PROSC, ERLIN2, NFAT5, ABLIM3, KDM4B, WDR47, TRIM37, SEC31A, HEXIM1, UBR5, FSBP, UBE4B, IKBKAP, OAZ2, SNX4, ZWINT, KIF4A, GADD45G, VAPB, CELF2, SMC2, TACC2, LYPLA2, WISP1, BMP10, CD2BP2, PARN, PSMG1, CTDNEP1, SLC2A10, TDP2, ETHE1, POLR1A, PCNT, STAMBP, NFATC1, EYA4, APBB3, SNAP29, ZMYM6, STAU1, MAP4K4, CLIC3, EML2, DDAH2, C6orf47, TTLL1, CBX7, BMP15, MBD3, NUDT3, PTTG1, BCL10, ZBED1, TOMM40, DNAL4, WHSC1, CYB5A, ALDH1A1, CYB5R3, PNP, EGFR, AK1, PLAT, ADA, CA2, ASS1, AGT, CSTA, KRAS, PDGFB, TGFB1, POMC, FSHB, CRYAB, LMNA, APOE, PMP2, TTR, FTL, FTH1, MT2A, BGLAP, ESR1, RAF1, FUCA1, CSTB, ANXA1, APOB, NR3C1, PRNP, S100B, GAPDH, ERBB2, TP53, MT1E, MT1F, HSPB1, TYMS, GNAI2, APP, INHA, HMGN2, IL6, EDN1, RPLP1, RPLP0, CLEC3B, ITGB1, PRKCB, KRT18, KRT8, UROD, PTMA, CDK1, S100A6, EIF4E, ENO1, GPI, NPM1, TH, LDHB, GPX1, DCN, PSAP, PFN1, APRT, EPRS, HSP90AA1, LYN, FH, ERCC1, SLC3A2, HSP90AB1, SOD3, MME, VIM, CYP3A4, KRT7, GNAI3, ANXA5, RPSA, SNRPA, GSTP1, LGALS1, QDPR, RBP1, FBP1, SPARC, GSTM1, ANXA4, CNP, WNT2, PDGFRB, HNRNPA1, POLA1, UCHL1, GSTT2, TMSB15A, HSPA1A, HSPA1B, GLI3, CCL3, TROVE2, AR, BCL2, TXN, PRKAR1A, HSPD1, CLU, IRF1, MAP2, EGR2, UMPS, PYGB, PYGM, LAMP1, G6PD, PC, ODC1, PCNA, NEFH, HARS, TPR, PTHLH, CKB, ANXA3, SKI, ACTN1, RNH1, CCL5, CFTR, NCAM1, EEF2, MT1G, TPT1, LCP1, PRKAR2A, ENO3, HSD17B1, MIF, CD99, HCLS1, FDPS, PKM, CCNB1, TYR, IDE, HNRNPL, DARS, ETS1, JUP, LIF, ETS2, FABP4, AKR1B1, PVR, EZR, UCHL3, HPGD, NME1, NQO1, VEGFA, CD1D, RPS2, CHN1, TCF3, DSP, CD44, NQO2, PDGFRA, STMN1, HSPA6, PRKCA, ATF7, CEBPB, GAP43, XBP1, LGALS3, ERCC2, RPL7, EGR1, IL1RN, PGAM1, RCC1, SDC1, ATF4, CDH2, TFEB, WT1, NFKB1, NCF2, CCNA2, BTF3, RAB3B, RAB5A, NR1D1, BCL3, MAK, CAPN3, IL11, CAST, HNF1A, MAG, RASA1, PDC, CDK11B, GSTM3, FLNA, TNFAIP3, KITLG, NT5E, MDK, ZP3, FGFR2, BGN, BMP6, OSBP, PCMT1, PAICS, IL10, SCP2, UBA1, NME2, HNRNPA2B1, CALB2, NR4A1, XPA, PTGS1, SFPQ, TUBG1, JAK1, SP100, AHCY, CFL1, BDNF, RRM1, GADD45A, EEF1B2, CDK2, APC, BRD2, FAS, YY1, DNAJB1, MT3, PSMA3, PSMA4, S100P, CTNNA2, CHML, HMGB2, TARS, ZFP36, ACVR2A, STOM, ARNT, CALR, IL1R2, PIK3R1, PSMB9, GSTM2, SSFA2, POLD1, MAPK1, DUSP1, PTPRM, LAP3, TNFRSF8, PTPN4, TPP2, IMPA1, KDM5A, IL12A, NOS3, SERPINB3, LMOD1, EEF1D, GNA11, PBLD, PRDX6, BLVRB, DDT, CMPK1, CDC27, CCND3, WEE1, CDC25B, ADSS, TSPO, CLIP1, SRI, SERPINB1, SSTR1, CORO1A, GDI1, S100A7, HOXA10, PRKAR2B, RRM2, FGF9, TIA1, AKT1, HNRNPH1, YWHAB, SFN, S100A11, PRDX2, CTH, HIST1H2BB, MAN1A1, TTK, MCM7, SHMT1, GRK5, USP6, CA8, CTNNB1, PHB, NF2, RPL22, ADM, SPRR2B, PTGS2, HRH1, CBS, PCK1, IRS1, AGL, MYH9, AHR, FLT4, PSMC2, CHI3L1, MAP2K2, CPOX, RPL4, NUDT1, PGM1, PPP1CC, SERPINB5, SREBF1, GMPR, SRP14, NUP62, ZEB1, TALDO1, SNCA, BRCA1, ANP32A, CAPG, CCT6A, PBX1, RPL13A, STAT3, MDH1, EIF2S3, LEP, MNDA, RGS2, CSK, MAP3K8, EIF1, HTR2B, PRKCI, ACTR1B, STAT5A, AKR1C3, EPS15, RPL35, CDKN2B, CDKN2C, NSG1, HTT, PTGFR, NR4A2, PTPN9, SYK, RANBP1, PSMC4, PPIC, MKI67, RANGAP1, RECQL, NSF, CDKN1B, BRCC3, RPL5, RPL21, RPL28, RPS9, MAP1B, GNPDA1, YAP1, IQGAP1, PLA2G4A, ALDH1A3, ID4, LGALS7, ZFP36L2, PREP, GLRB, RFX2, ARCN1, SERPINB4, PRRC2A, NES, PIK3CG, MAPKAPK2, ALDH9A1, RPL34, TGM4, SLC11A2, NASP, FASN, DHPS, CCT3, ALDH7A1, CDC34, INPP1, CENPF, UBE2A, SARS, CSNK1E, ARL4D, PSMB3, MCM2, ACADVL, RBM25, HINT1, FHIT, NUP153, RGS3, RGS4, TSC2, GSK3B, SEPHS1, MTHFS, GMPS, CDKN1C, MRE11A, HNMT, GNAQ, MEOX1, MMP14, GDI2, SERPINB9, MXI1, METAP2, CDK7, KNTC1, RPL14, CCT8, ATP1A2, ANXA11, PAPOLA, FXR1, RAB28, FABP6, PLCD1, DUSP3, BRCA2, IRAK1, STAT5B, USP11, VAMP7, PRKX, AFF3, NR0B1, HDGF, NEK2, NEK3, NEK4, HNRNPA3, KPNA2, KPNA1, MAP2K6, ARHGDIB, STAT2, GTF2A1, MSH6, KIF11, HRSP12, STC1, AKR1C2, PLK1, DAPK1, SUCLG1, COPA, LIMK2, PTTG1IP, TTC3, RCAN1, SMTN, BLM, RARS, ATXN3, ATXN1, ATN1, TERF1, OAZ1, YARS, PRKAA2, RAD23B, EPHA4, GYS2, EMP2, ALDH18A1, EIF5, NR1H2, CSE1L, VCP, MLLT10, CASP6, CDH11, CDH13, TPD52, GFER, HNRNPH2, SUMO3, EIF3B, DLX5, ARPP19, HDAC4, EIF6, SIK1, SOX8, GEMIN4, EVC, SESN2, SESN3, EPPK1, TIRAP, HIST1H2BD, PTEN, PPP4C, GABARAPL2, ACTB, EIF4A1, RPS20, SNAP25, CDC42, SRP54, CXCR4, UBE2M, ACTR2, ABCE1, RPS3A, PSME3, STXBP1, B2M, PKIA, UFM1, DCAF7, RPS7, PPP1CA, CALM2, NCS1, PSMC1, RPS8, RPS15A, UBE2H, RPS14, RPS11, SNRPD3, BTG1, TMSB4X, RPL7A, ACTA2, RPL23A, RPS6, HIST1H2BC, RAP1A, RPS25, RPS26, RPL30, RPL10A, RPL11, RPS27A, GRB2, RAC1, GNAI1, YWHAZ, UBE2B, SNRPN, DYNLL1, SKP1, RPS21, EIF5A, RACK1, ACTG2, UBE2I, TMSB10, YBX1, ACTC1, EEF1A1, PAFAH1B2, CXADR, IGBP1, ADAM8, GTF2I, DLG4, SRPK2, CCT2, RAE1, IRX3, GSTO1, ADAM17, ELF3, MAP1A, CRADD, ADARB1, GPLD1, MT1H, MT1X, GPSM2, SSBP2, RPL24, SMAD3, RPL19, MUC5AC, PKD1, XIAP, FOXO4, RBM3, PITPNA, HDLBP, CDK6, CDK5, CDK16, PURA, HSF1, IRF9, MDM2, PLIN5, SPTBN1, SET, RUNX1, RELB, GALK2, FABP5, HMGCS1, SLC7A5, MC2R, XPC, EWSR1, POU5F1, BNC1, OCRL, ROR1, TAGLN, MEF2A, DHODH, CENPE, NRG1, ID2, SP3, ID3, MAP2K1, TEK, FKBP4, DST, GSTM4, HHEX, CREM, TGFBR3, CENPC, RELA, KRT17, TLE1, GLO1, YWHAH, ICA1, PTK2, EEF1A2, PRKCD, PTPN11, EXOSC9, AOX1, MEF2C, SULT2A1, RING1, RAD51, FMR1, PRDX1, SOX4, RPL18, C1QBP, TJP1, ZFP36L1, BAX, MCL1, TNK2, SRSF1, FOXM1, PPP3CA, CRYZ, PPID, SSRP1, CAMSAP2, NSUN2, NCBP1, EP300, AHNAK, DNAH14, FAAP100, BST2, SREBF2, ARHGEF5, FOXO1, TWF1, AKAP13, TROAP, CDC20, GRSF1, MERTK, DPYD, HYAL2, ILF2, ILF3, FOXC1, DLG1, TAF10, MYO1E, PTP4A2, BNIP3, HSPB3, MLLT11, ARHGAP5, AKAP6, STK4, COASY, TRAF1, PLA2G7, CHAF1B, MTAP, CALCOCO2, EIF2B5, BAMBI, TARDBP, FADD, MAP2K5, MAPK7, PAK2, CBLB, DUSP8, DNAJC3, SRSF5, G3BP1, CLN3, NMI, SKP2, GRB10, MTA1, ITGB3BP, PPIL2, PDCL, MAPK8IP2, UBE2V1, DYNC1I2, ORC1, ILK, IKZF1, SNTA1, SNTB2, PPIG, TCOF1, GOLGA4, MYO9B, NFATC2, SMAD4, BIRC3, MTM1, SQSTM1, TUBB3, PPP1R1A, EIF4EBP1, EIF4EBP2, RIPK1, HDAC1, CAMK2D, DCTN2, PKD2, NAE1, DGKZ, IQGAP2, SNX1, MTMR1, MTMR2, CUL4B, TP53BP2, FHL1, ACVR2B, TUBA3C, RUNX3, NACA, BLMH, EXOSC2, BMPR2, SNTB1, TUBB2A, KLF9, C1D, CACNA1C, RUNX2, CDK13, CIRBP, CAMK1, COTL1, COX17, TOB2, DAG1, BOP1, EIF3A, POLA2, ZMYM3, DCTN1, NPAT, EIF2B1, MAP7, CTTN, TRIM25, FLNC, GAS6, CAPRIN1, GRB14, HES1, SLBP, NFE2L1, NEDD9, ITPR3, ZNF268, RASA3, PLS1, ESPL1, KANK1, SMC1A, GINS1, LPIN1, RFTN1, CASP8, NAA30, KIF22, MEF2D, CHD4, STARD3, PTGR1, NFATC4, ZNF638, KPNB1, CUL7, NAA25, KIAA0101, EMC2, FAM175B, SEPT2, SART3, NCAPD2, HERC3, JOSD1, KARS, EEA1, PAFAH1B3, PLCL1, PRKD1, PCM1, PPP2R5A, PPP2R5B, PTGES3, STK38, PPP2R4, QPRT, RASA2, RNPS1, ANKRD1, RPS6KA2, PCBP1, UBE3C, MTFR1, DLGAP5, CNN3, RPS6KA1, PPP1R7, NR0B2, STIL, RGN, SPA17, MAPRE2, NCOA2, DIXDC1, TRADD, TRIP10, TRIP6, MAPRE1, TSC22D1, ELAVL1, KISS1, MYLK, TAB1, NPY5R, NCOA1, SMAD2, SMAD1, UBE2V2, STK11, CCDC85B, ADIRF, EZH2, ZFHX3, ZIC1, ZYX, HSPB2, SEPT7, ADRM1, CCDC6, UAP1, PDCD2, PKN1, PKN2, MAPK14, CDC37, SGCB, CCNG2, NREP, DBN1, FSCN1, HIF1A, IFI16, CDKN3, ZSCAN26, DECR1, KYNU, UBE2S, HIST2H2BE, PTPN21, DUSP6, HADH, AOC3, TPD52L1, CPEB4, CSPP1, FAM110C, MICA, AAK1, KIZ, ERCC6L, RALGAPA2, QRICH1, LRRFIP1, FAM161A, NBPF1, MAP7D1, CHD9, WDR72, TTLL9, RABL6, GLYR1, ZBED5, COX19, LARP7, FILIP1L, ARID4B, FLYWCH1, C4orf46, RFTN2, FAM98B, ARHGAP29, SBK1, PDCD4, NCBP3, IFI44L, PHLDA2, PLEKHO1, C1QTNF9B-AS1, DCAF6, SGOL1, HERC4, BCORL1, TECRL, MDH1B, METTL10, RALGPS1, HABP4, DGKK, WIPI1, SAMD4B, TBCEL, CEP170, FNBP1L, HIVEP3, ARMC4, UBR4, STXBP5, KIAA1217, CAMSAP1, KANK4, CPSF3L, DCAF8, RSPH4A, THEMIS2, STPG1, FAM72A, CROCC, MEX3C, HECTD2, ATF7IP2, RIF1, STRIP1, CDC42BPA, CFAP126, PDE4DIP, IRAK1BP1, FAM208B, ZCCHC6, MBNL2, LRRC16A, KANK2, KAZN, KCTD11, CDCA2, IQSEC1, SFRP4, ZFAND6, OTUD7B, RALGAPA1, THOC7, NADSYN1, TWF2, DESI1, JADE1, PPP4R3A, SPOPL, NAPEPLD, FAM72D, RGS7BP, TENM4, PTRF, MAST2, PNCK, C16orf46, KLC3, LRRC8B, CNKSR3, RFWD3, PPIP5K1, PSRC1, SHQ1, KLHDC10, FBXO38, BRAT1, ZC3H14, LARP1, AGTRAP, SARM1, NHS, KLHL24, ANKRD12, ANKRD11, AFTPH, CRTC3, PARM1, C6orf89, DRAM2, ATF7IP, MPRIP, RAB11FIP1, NSMF, DSTYK, RNF19B, BNC2, CCDC81, RNF111, CCDC141, DNAH12, FAM83H, RBPMS2, FAM65A, GK5, RNF165, UBR3, FAM101A, CEP128, FGD6, PHLPP2, SYDE1, NEK10, VPS13C, RAPH1, USP45, NOL8, SSH2, RUFY3, SV2A, BZW1, ASRGL1, DHX30, MCM10, COPS6, MAEA, EPM2AIP1, DHX32, SH3BP5L, ARC, CXXC5, PID1, NRK, SETX, NOTCH2NL, ZFYVE16, PIWIL4, TMC6, NUFIP2, RNF144B, COMMD6, HAUS6, WAPL, PODN, IRF2BP2, CPEB2, BCDIN3D, KCTD20, SPRED1, SRGAP1, NECAB2, FGD2, PNPLA5, HUWE1, PXK, CENPV, S100A7A, NEK8, PHLDB2, ZBTB33, NBPF11, PEG10, PRUNE, PABPN1, MTDH, MAGI2, RTN4RL1, USP48, CASZ1, VASH2, LRRTM4, CAND1, HOOK3, JAZF1, SPATA24, OSTM1, RASSF3, NLRC5, CHD1L, GPBP1, TRIM69, RPS19BP1, RALGPS2, CARM1, FAM72B, COMMD2, METTL23, C19orf68, GAS2L3, DGKH, CEP57, RNF130, SPATS2, DNAAF5, KIF18B, PDSS2, THNSL2, TDRP, C2CD5, MIB1, CAMK1D, ERC1, MINA, RBM45, ZDHHC17, CRLF3, SIAH1, CREBRF, AEBP1, LRRC49, HID1, PLEKHH2, DNAH10, MAP4K3, CCDC50, CCDC103, TEX14, FAM114A1, MGA, UBR1, CHERP, WWC1, DHX40, SKA3, SIRT2, BAP18, KLHL7, DDIAS, CMIP, DHX37, YAF2, AMOTL1, EFCAB13, CKAP2L, TRIM22, THNSL1, C6orf165, CMTR2, CFAP46, ANKRD13A, ZBED8, PHACTR4, KMT2E, SCYL3, XRN1, ASPM, CMTM8, RDH10, SPG20, CNTROB, EID3, ADSSL1, CCAR2, CRIPAK, CFAP52, AGGF1, MT1M, ARHGAP18, ASCC3, FAM19A2, MPP5, ZCCHC7, MINK1, AFAP1L2, TAB3, NKAP, FAM101B, NBPF15, COMMD1, DRAM1, RNF182, ARFGAP2, AOPEP, ZNF655, KLHDC1, C7orf31, KIAA1958, ENAH, ABTB2, CNEP1R1, JMY, MFSD2A, PCSK9, HSD17B11, SERBP1, HJURP, NFATC2IP, BBOF1, LRRC16B, LSM14A, PAPD5, RCBTB1, RGS22, CPEB3, ABCF1, PLPP5, GSTCD, DUSP18, NGDN, MCPH1, SHCBP1, APPL2, NAV1, VPS37A, ZNF397, USP32, ARID1B, FLCN, REPS2, NUDT10, DBF4B, SEMA6D, CASC5, LILRB1, CEP70, CTCFL, KIF18A, RP9, PPP1R14C, RHEBL1, MPLKIP, PUM2, SETD6, TBC1D15, SPATA18, FAM110B, IFI44, NT5C, KIAA1524, PNPT1, URGCP, BICD2, NEK9, DLG5, STK35, LRRC8C, NEK7, RB1CC1, MICAL1, DNAH5, SSH3, UTP15, GEMIN5, IPO4, PNISR, FNIP1, UBASH3B, SHROOM3, GSG2, ABHD5, ZC3H15, PPIL4, PPP1R13L, HDAC7, CEMIP, PDCD6IP, PRUNE2, BLNK, TRIM41, CHTF18, N6AMT2, NUDCD2, TNFAIP8L1, ZFPM2, CKAP2, ATXN2L, ARAP3, IPCEF1, STAB2, RASSF5, PALLD, METTL21A, GEMIN6, PSPC1, GPR98, SYNE2, DNAJC9, BBX, NANOS1, ARNTL2, RIN2, RFFL, AQP3, SEC14L1, TRIB2, SNX19, TOPBP1, ELMO1, BAP1, NDRG1, HSPH1, LPGAT1, GCN1, NUP205, APPBP2, ANKS1A, SGCD, DYRK2, NSMAF, ANP32B, TFG, TNR, HDAC2, PROX1, CREBBP, SYMPK, TAF15, HAS2, TANK, APBB2, HPS1, FGF13, ARHGEF2, EMG1, GLMN, ATP6V0A1, LPP, RBPMS, HIST1H2BH, PTP4A1, PRKCDBP, RFK, FBXO32, UBE2E3, FBXW5, TEKT1, FAM162A, TP53INP1, EXOC4, KIAA1191, PNPLA2, TTC17, NABP1, ACD, MIB2, EME1, ISG20, UBE2W, DACT3, EXOSC8, SLC22A18, ARL8A, TADA1, CHCHD1, MOAP1, FAM136A, ARMC5, SYTL4, PPP1R14B, CTHRC1, HAUS1, OPTN, TUBGCP3, GPRASP2, TMCO6, NUDT16, ANAPC16, MSI2, SNRNP40, DNAH11, ELP4, MALSU1, DAZAP1, WDR34, MVB12A, CYFIP2, SAT2, NRBF2, CDCA5, CPNE2, DTD2, S100A16, IFT43, OTUB1, DPH3, CFAP36, NUDT11, RMND5B, ZNF274, CDCA7L, C5orf30, TCTN2, MASTL, MYO19, TONSL, PRR11, DOCK6, NAF1, FBXL20, BOD1, ABHD14B, PAWR, RSRC1, ITCH, VCPIP1, CHAMP1, FEM1C, ZFYVE19, RITA1, SCYL1, FAM84B, ZFR, SGCZ, C9orf72, RMDN2, FGD4, DRC1, PCMTD1, GLT1D1, CMTM3, NOL4L, VSTM2L, ZNF578, ZNF641, SPATA13, FRMD6, C8orf37, ASB16, SLC46A1, ANKRD27, CLIC6, IPO9, NECAB3, INPP4A, ERMAP, KLHL5, NEDD4L, QKI, SYNGAP1, FAM193B, NEK1, PLIN4, BTBD9, SMG1, KIF20B, DLC1, MTMR9, ALPK1, HHIP, MAGI1, SPAG5, PANX2, PASK, CITED4, MED15, ERGIC2, NUDCD1, USP28, TRIB1, RANBP9, SRPK1, STRBP, ATOH8, CEP89, OSBPL9, FAM129B, TCF12, MYCBP, CDC5L, PFDN5, GPER1, MPHOSPH8, MPHOSPH9, PKP4, TSC22D3, S100A13, TTC1, DNAJC7, C12orf57, PHB2, COPS8, RAD9A, CHP1, FEZ1, PITX2, LYST, DOK1, MTR, HSD17B10, SMAD5, BARD1, HNRNPAB, LITAF, NAP1L4, CDC6, MDFI, CIB1, CCT7, ARID3A, HAUS7, PRMT1, DUSP9, CITED1, TEP1, VRK1, GDF15, NCAPG, HOPX, PAIP2, MAPKAP1, NABP2, MYBBP1A, AIF1L, SLF1, DBNDD2, CORO1B, CPPED1, SDF4, PDCD2L, AIFM2, LARP6, GINS4, PELO, FAM213A, LXN, FAM64A, MARVELD1, FEM1A, CCM2, INPP5K, DIDO1, IER2, LRRC1, TBCD, NDC1, MKNK1, TUBB6, PDCD10, MENT, HTATIP2, BDH2, FAM195A, THUMPD3, DUSP26, ADI1, RNF126, SNRNP25, KATNB1, TUBB2B, MLST8, TRIM62, PHF20, DUSP23, TIPIN, KATNAL1, ACAT2, RBM4, CDCA7, PAPOLG, CARD10, RBM24, SORBS1, OSBPL10, NAA15, PINK1, CLEC7A, NUSAP1, TEX15, OSBPL1A, FANCD2, BEX2, PACSIN1, SCAPER, HDAC8, POLDIP3, DUSP16, FUT8, SPRR2G, NIFK, PARD6B, TRIM34, YTHDF1, WNK3, BACH2, PANK2, UACA, WDR11, CRNKL1, PRKD2, FAM129A, TRIM8, FOXP3, UBXN6, SPRY4, TRIM9, TRIM6, TRIM4, TRIM2, INO80B, LRRCC1, UNK, ZCCHC2, XPO4, CEP44, ZNF436, KLHL4, STRADB, ACTR6, SENP6, NIF3L1, NAA50, UBA5, PAIP1, NBPF3, IQCG, COMMD4, TOLLIP, RNF38, RACGAP1, CCDC113, SIK2, WWP1, CCDC8, BCL11A, SDCBP2, NUCKS1, UPF3A, SPTBN4, SH3BGRL3, TRIOBP, TSPYL2, BLZF1, PDCL3, TNKS2, TAOK3, RAB3GAP2, DHX36, HIPK2, EPB41L4B, PABPC3, KCTD10, TXNIP, DSN1, CHMP4B, FBXL15, WNK1, TUBB1, FAM83D, SENP3, PLEKHA4, RGCC, GSTO2, DUSP21, FAM96A, DHX35, BICC1, ARMC7, AZI2, EGLN3, LRRC19, ASB8, SMYD3, DOCK5, WDR26, SUDS3, AUNIP, METTL8, UBE2Z, RMND5A, CSRP2BP, METTL7A, ZNF395, AKTIP, ECT2, REEP1, HN1L, PANK3, CHODL, COPS7B, ELP3, LIN28A, MEAF6, PLEKHA5, SMURF2, UPF2, PLEKHA2, CACYBP, RRAGC, RC3H2, IFT122, BEX1, MKNK2, AS3MT, TNS1, VEZT, ETNK1, APOBEC3G, EML4, NEK6, EPG5, ARHGEF10L, CWC22, SYTL2, RAVER2, AGO4, CSNK1G1, EPB41L4A, CD248, SRA1, GOPC, SEPSECS, RANGRF, MYO10, CD209, SLC40A1, ARFGAP3, SSU72, PARD6A, EXOSC4, UBE2T, SPAG4, ADAP2, ACP6, BRD7, PLCB1, CASS4, HEYL, TCF7L2, IFT46, HINT3, HPS4, RRAGD, PFDN4, KMT5A, EXOSC3, KIF13B, GPHN, PDLIM7, ACSS2, ASH1L, EIF2B3, MBNL1, CYP26B1, SLC2A4RG, PDGFC, EIF4ENIF1, TULP4, STRN4, IL17RB, LATS2, CDC42SE2, UBQLN4, CDC42SE1, SNX15, DUSP22, RASSF1, KCNIP2, RPRM, RAD18, HOMER3, BRWD1, PNPLA3, NRBP2, SMC4, MDN1, MBNL3, DDX28, LIN7C, SPATS2L, UFSP2, TDP1, DCAF13, RNF19A, EXOC1, NDFIP2, FANCI, ARL8B, GNL3L, DNAAF2, TBCCD1, ARMC1, RLIM, HAUS2, KBTBD4, RBM22, RBFOX1, PARPBP, HCFC1R1, GEMIN8, TRNAU1AP, DDIT4, HYPK, MKS1, ING3, AATF, SPHK1, ABI2, DNAH9, DACT1, BCLAF1, ZAK, MIS18A, NKIRAS1, PLEK2, PLK2, STMN3, FAM120A, IL37, GRHL1, DTL, ITSN2, EHD3, FLRT3, FLRT1, LMCD1, DSPP, THYN1, CRIPT, HACD3, NDUFA13, MARK1, SH3BP4, SPATA7, CAMSAP3, SLAIN2, FNIP2, PAK7, CTTNBP2NL, DNAH1, MYEF2, KLHL42, WDR35, HECW2, STARD9, FRMD4A, IMPACT, ATXN10, DNMT3B, SPRR3, PI4KB, HECA, UXT, ARPP21, HDAC6, SPAST, VPS29, EIF3K, GRHPR, DNAJB9, GABBR1, RNF14, ZMYM2, TJP2, DNAJB4, VTI1B, ADD3, PLEKHB1, LRWD1, MIOX, SLC23A2, ZRANB1, TES, KDM5B, DMBT1, PARP2, LIMD1, MLX, LIMA1, ASIC3, TBK1, DCDC2, SLC7A8, DDX20, ADAMTS1, SHPK, USP25, BAIAP2L1, EVL, EIF2B4, DACH1, DNAI1, TEKT2, SERPINB13, PLXNA1, ZMYM5, MOSPD1, ERRFI1, TUBD1, FBXL7, NOCT, FEM1B, FBXO10, FBXO9, FBXL2, TNIK, PITPNC1, CDC42EP3, NXT1, FBXO5, HDAC9, AGO2, ELF5, NUP50, BLOC1S6, TAOK2, RAB23, INTU, RIMKLB, ZMIZ1, NDRG4, PPM1H, CORO1C, TP53TG3, PYCARD, MYO6, NFU1, PRPF19, PHTF1, SUFU, BOK, SYNRG, NDRG2, G3BP2, RPH3AL, STUB1, CDC14A, SNX6, GTF2A1L, DIMT1, TTF2, NSFL1C, MACF1, PPP6R1, AGAP1, TRIM35, PLCL2, SMG5, MAPK8IP3, TRAK1, AGTPBP1, DICER1, MAPRE3, PA2G4, EXO1, CDK11A, SMC3, MAPK8IP1, HDAC5, TRPC6, NIP7, GNE, RUVBL2, AKT3, POMP, LZTS1, RNF6, POLH, RUVBL1, TNFSF13B, INVS, FARSA, DRG1, PKIG, STK38L, EPB41L3, SIK3, FRMD4B, FAN1, PTPN22, CRYL1, GIT1, SH3GLB1, ZDHHC9, RRP7A, SBDS, TPRKB, FAM96B, RTCB, TSC22D4, NOC2L, RPL36, KNSTRN, ZNF175, MTF2, TLN1, NFE2L3, DAAM1, WDR7, USP15, FARP1, FAM65B, GPSM3, MYO5A, DTNA, MAP4K5, WIPI2, LAS1L, ARIH1, CSDC2, ASB3, YTHDF2, HEY1, PCYT1B, TNPO3, SRPRB, GMPPB, CDC42BPB, RBM8A, ZNF706, SNX9, HEBP2, HCFC2, FHOD1, IRAK3, PSAT1, CPQ, TACC3, EID1, MAD1L1, STK24, BZW2, COMMD10, SNCAIP, CABIN1, IGF2BP2, CSNK1G3, SLC30A1, SESN1, STON1, NCOA3, MAP3K4, DUSP10, IVNS1ABP, CAMTA1, LOC440434 |
GO:0005739 | CC | mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
VWA8, GTPBP10, NUDT19, AGPS, ACOT7, HAX1, EYA2, NDUFS8, CLIC1, NDUFA4, NME4, ACACB, ACOT8, TPP1, TIMM23, UQCRQ, RAB29, SLC27A2, GNPAT, NDUFA1, ACOX3, SPTLC2, FANCG, OGT, CD3EAP, CYP27B1, NDUFS4, ADAM12, AKR7A2, RAD51C, BCL2L11, FOXO3, AKAP10, GSTZ1, TRIAP1, GATC, SLC25A17, C21orf2, IDH3B, BNIP3L, SH3BP5, PARK2, TRAK2, OPA1, KIF1B, FADS1, PPL, MRPS14, DIAPH2, NOL3, PTCD1, ATG13, LRP5, NDUFS2, MPDU1, NME6, ERN1, ECI2, LYPLA1, TRMU, SLC25A12, PPP1R15A, IDH1, GATB, ALDH1L1, TUSC2, ATP5H, ATP5L, CLPX, DDAH1, URI1, PROSC, GLS, NDUFB6, MFN2, NDUFB4, NDUFA7, ZNF205, LETM1, SLC25A14, FARS2, ETHE1, AIFM1, DDAH2, TOMM40, CYB5R3, GOT2, KRAS, GNRH1, CRYAB, SOD2, TP53, CYP1A1, TYMS, CYBB, CYP17A1, CYP11A1, SLC25A5, MPO, CYP2E1, FYN, CDK1, TH, LDHB, GPX1, PSAP, CTSB, UQCRH, FH, ANXA6, HSP90AB1, MMP2, PDHA1, CYC1, GSTP1, QDPR, DLD, COX6C, PARP1, ALDOC, PET100, HSPA1A, HSPA1B, FDX1, BCL2, DLAT, TXN, COX5B, MGST1, CYP2D6, HSPD1, CLU, HSPA5, PDHB, DBT, PC, MTHFD1, NEFH, HARS, SLC25A4, CKB, CKMT1A, BCKDHA, P4HA1, MTHFD2, HCLS1, PKM, IDE, COX6B1, CYP11B1, HIVEP1, ARSB, COX7C, PRKCA, GJA1, CKMT2, NDUFB7, PRKACA, GM2A, RPL35A, LIG1, ATP5J, CYP11B2, HK1, NDUFV2, ELK1, NFKB1, MAOA, SDHB, BCKDHB, COMT, TGM2, SCP2, UBA1, UQCRC2, ME2, GCSH, DTYMK, COX7B, MPST, UCP1, PLN, STOM, AK4, MAOB, MAPK3, G0S2, NDUFS1, MAPK1, LAP3, CASP1, ATP5D, ECHS1, PPP2R1A, TSPO, ADSL, SRI, ALDH1B1, SDHA, DNAJA1, AKT1, UQCRC1, YWHAB, SFN, GK, ACSL1, DUT, SHMT1, PHB, BSG, GLRX, HMGCL, MAP2K2, ATP5C1, CPOX, NUDT1, PPP1CC, GPX4, SNCA, MPV17, FEN1, IFI27, MDH1, MDH2, RGS2, ELK3, ECI1, LRPPRC, CRAT, TSFM, VDAC2, ACADSB, MAPK8, MAPK9, UQCRFS1, ATP5O, IDH2, RPL34, FASN, ALDH7A1, GLUD2, HARS2, CASP4, STAR, PSMB3, ACADVL, PSEN1, FHIT, RANBP2, GSK3B, CPT1A, CDK7, DAP3, BCAP31, HSD17B4, RAP1GDS1, HRSP12, MRPL12, SUCLG1, HCCS, POLG, RARS, BCAT1, ALDH18A1, HADHB, CASP9, GFER, OXCT1, UCP3, BID, NDUFV3, CMC4, MTCP1, ATP5I, SYNJ2BP, SESN2, YBEY, NLRP5, PTEN, ROMO1, ABCE1, HSPE1, STXBP1, RPS15A, YWHAE, RPS14, RAB11A, YWHAZ, DYNLL1, GNG5, RACK1, NTHL1, ABAT, MRPS25, MRPS10, MRPS5, MRPS36, MRPS34, CYCS, TFAM, SLC25A3, PLIN5, E2F1, DHODH, OGDH, ALDH6A1, MAP2K1, FKBP4, SSBP1, YWHAH, PTPN11, RAD51, PRDX1, SOX4, C1QBP, BAX, MCL1, PPP3CA, NCBP1, PMPCA, FOXO1, GRSF1, ILF3, BNIP3, ECH1, PRDX4, CLN3, TCIRG1, RIPK1, TP53BP2, RAB32, ALKBH1, PMAIP1, AUH, COX17, TFDP1, ICT1, NBR1, KCNJ11, CASP8, STARD3, EMC2, LARS2, KARS, POLD3, ACOX1, PDK1, ERBB4, TOMM20, MTFR1, STK11, RAB11B, CRY1, MAPK14, MRPL23, DPYSL2, FXN, PDK4, CYP1B1, DECR1, KYNU, CLPP, ME3, PCK2, HADH, DGUOK, TXNRD1, SPHKAP, PGS1, ALDH1L2, TIMM50, NADK2, CCDC58, HS1BP3, CMPK2, EARS2, PITRM1, COX20, SLC25A30, THEM4, ERCC6L2, ATPAF1, FAM72A, MARC1, KANK2, TTC19, XAF1, MRM1, HIBCH, PTRF, RPUSD3, MRPL14, MTFR2, TMEM65, SARM1, MTHFD1L, OLFM4, APOOL, HSDL2, SLC25A26, DHX30, PARS2, ENOSF1, DHX32, MAVS, DHX29, HDDC2, MAATS1, CMC1, USP48, NT5DC3, NDUFA11, ECHDC2, PPARGC1B, TMTC1, ADHFE1, MSRB3, MRPL41, SUPV3L1, THNSL1, MICU2, CLYBL, NDUFAF2, ARMC10, PPM1K, TCAIM, PRSS35, GTPBP8, GUF1, PNKD, TOMM5, ZADH2, OXR1, ATAD1, UXS1, ZMIZ2, ABHD11, PPTC7, GADD45GIP1, NUBPL, TBC1D15, FAM110B, MRPL30, NT5C, PNPT1, MGARP, RHBDD1, COX7B2, PTPMT1, NUDT8, DCAKD, SLC44A1, PALLD, SYNE2, BRI3BP, PPM1E, CHCHD10, CPT1B, GBF1, MRPS31, AKAP1, ESR2, RAB8B, BAD, RFK, GTPBP3, TBRG4, FAM162A, CHCHD1, MOAP1, MIEF2, RPUSD4, SLC25A36, AP2M1, DNAJC19, RMDN1, ECHDC3, MTFMT, STARD4, LGALS12, MALSU1, PTCD3, PERP, C7orf55, COX14, APOPT1, DCAF5, PACRG, DGAT2, TRNT1, TEFM, GFM1, MCCC1, SECISBP2, NMNAT3, YME1L1, MYCBP, ACOX2, MTERF1, TIMM17A, PHB2, SDHC, FEZ1, HSD17B10, TXN2, MIPEP, ACO2, CCT7, NIPSNAP1, ELAC2, MACROD1, MGME1, AIFM2, UQCC2, FAM213A, AGMAT, TACO1, DHRS4, APOO, ABHD6, DUSP26, MECR, NUDT9, ACAT2, FUNDC2, SFXN3, HINT2, BBC3, PINK1, MRPL1, MRPS26, PANK2, MRPL37, UACA, MAP1LC3B, SLIRP, CCDC90B, NIF3L1, QRSL1, GABARAPL1, RAB1B, MTIF3, C12orf65, ACBD3, PIF1, ACSS3, METTL17, MTHFD2L, SFXN1, GRPEL1, AS3MT, PLGRKT, CAPN10, MCCC2, TRIM39, MRS2, MRPL47, ABCB6, NGB, ACP6, NOX4, ACOT13, TIMMDC1, MRPL40, XPNPEP3, PFDN4, STARD7, CTPS2, GLRX2, TOMM22, DEPP, LYRM2, ABHD10, DDX28, NDFIP2, ATAD3A, GNL3L, ARMC1, MTPAP, ATP5SL, ARGLU1, C14orf119, AURKAIP1, DDIT4, NDUFB11, OCIAD1, SYBU, HAO2, CISD1, MRPL35, COQ3, MAT2B, DNAJC27, MRPL15, NDUFAF4, HACD3, NDUFA13, TOMM7, PAK7, SUCLA2, AASS, MUTYH, AK3, ANXA10, CRLS1, SLC25A13, CROT, SARDH, BAG5, MTUS1, NDRG4, MAFF, PYCARD, NFU1, BOK, NOL7, TRAK1, AGTPBP1, PRELID1, BCS1L, VDAC3, HIF3A, MRPS28, COA3, POLDIP2, ACOT9, MRPS2, COQ4, REXO2, BOLA1, FAM65B, SAMM50, GMPPB, HEBP2, MRPS18B, MRPL42, CHCHD2, COX11 |
GO:0005740 | CC | mitochondrial envelope | The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. |
MAOB, HADHB, ABCB6, ADAP2, ABCF2 |
GO:0005741 | CC | mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
HAX1, DDX3X, ACACB, KMO, CYP27B1, CYB5B, BCL2L11, BNIP3L, OPA1, ACSL4, PPP1R15A, MFN2, TOMM40, CYB5A, CYB5R3, ASS1, RAF1, PGR, CNP, BCL2, MGST1, NME1, GJA1, HK1, MAOA, MT3, MAOB, TSPO, GK, ACSL1, PPP1CC, IFI27, VDAC2, ATP5G3, SLC11A2, CPT1A, EPHA4, HADHB, BID, ATP5G2, BAX, MCL1, BNIP3, COASY, RAB32, PMAIP1, LPIN1, CASP8, TOMM20, MARC1, LETMD1, VPS13C, MAVS, SPG20, TOMM5, CISD2, FAM73A, SPATA18, SLC44A1, RTN4IP1, BRI3BP, CPT1B, AKAP1, BCL2L2, BAD, MOAP1, MIEF2, MYO19, PHB2, AIFM2, PINK1, MFF, GPAM, ABCB6, TOMM22, CISD1, TOMM7, PI4KB, ACSL6, BOK, VDAC3, SH3GLB1, SAMM50 |
GO:0005742 | CC | mitochondrial outer membrane translocase complex | A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments. |
TOMM40, TOMM20, TOMM5, PINK1, TOMM22, TOMM7 |
GO:0005743 | CC | mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
UQCRHL, NDUFA4, NME4, NDUFAB1, TIMM23, UQCRQ, UQCR11, KMO, MRPS12, NDUFA1, NDUFS4, PRODH, NDUFA2, OPA1, MRPS14, TIMM17B, NDUFS6, MRPL33, SLC25A12, ATP5H, ATP5L, CLPX, ABCA8, NDUFB6, NDUFB4, NDUFB8, NDUFA7, LETM1, SLC25A14, NDUFA10, CDS2, AIFM1, NDUFB10, CYB5R3, GOT2, TYMS, CYP11A1, SLC25A5, UQCRH, CYC1, CNP, COX6C, FGR, COX5B, MGST1, HSPD1, COX6A1, SLC25A4, CKMT1A, HSD3B1, COX6B1, UQCRB, CYP11B1, COX7C, SLC25A16, CKMT2, NDUFB7, LGALS3, ATP5J, CYP11B2, NDUFV2, COX5A, SDHB, UQCRC2, COX7B, UCP1, HSD3B2, MAOB, ABCD3, ATP5D, SDHA, PRKAR2B, UQCRC1, PHB, HMGCL, ATP5C1, CPOX, MPV17, STAT3, MDH2, ECI1, CRAT, GPD2, VDAC2, PLA2G4A, UQCRFS1, ATP5O, IDH2, MRPL19, ACADVL, PSEN1, CPT1A, GATM, DAP3, ALDH3A2, MRPL12, SLC25A1, SUCLG1, HCCS, ALDH18A1, HADHB, UCP2, UCP3, NDUFV3, ATP5I, ROMO1, MRPS25, MRPS10, MRPS5, MRPS36, MRPS21, MRPS34, CYCS, SLC25A3, DHODH, PMPCA, ICT1, MRPL23, PDK4, NDUFA5, HADH, LETM2, PGS1, NDUFAF6, TIMM50, MRPL51, OCIAD2, SLC25A30, THEM4, ATAD3B, NDUFAF5, MARC1, TTC19, MRPL54, MRPL14, LETMD1, SFXN4, SLC25A26, MRPL21, MRPL55, MRPL52, NDUFA11, MRPL41, MICU2, NDUFAF2, GUF1, MRPL50, RDH13, DUSP18, MRPL30, PTPMT1, SLC25A43, MRPS31, CHCHD1, SLC25A36, DNAJC19, MRPL38, OMA1, PTCD3, MRPL48, SLC25A44, COQ2, DHRS1, MCCC1, YME1L1, TIMM17A, PHB2, SDHC, NIPSNAP1, MRPL34, UQCC2, MTG1, NDUFAF3, SLC25A23, PINK1, MRPL32, MRPL4, MRPL1, MRPS26, MRPL37, SLC25A39, SLC25A18, GHITM, MTG2, MTHFD2L, SFXN1, MRPL44, SLC25A19, GPAM, MRS2, MRPL47, ABCB6, TIMMDC1, MRPL40, ABCB10, MRPL17, TOMM22, ATAD3A, MRPS18A, AURKAIP1, NDUFB11, MRPL16, SLC25A37, MRPL35, COQ3, MRPL15, NDUFAF4, NDUFA13, MRPL36, SLC25A10, UQCR10, CRLS1, SLC25A13, BOK, HIGD1A, EXOG, GSTK1, MRPS28, COQ4, SAMM50, TIMM10B, DNAJC15, SLC25A15, MRPS18B, MRPL42, COX11 |
GO:0005744 | CC | mitochondrial inner membrane presequence translocase complex | The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. |
TIMM23, TIMM17B, TIMM50, TIMM17A, TIMM21 |
GO:0005746 | CC | mitochondrial respiratory chain | The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. |
UQCRH, UQCRB, COX7B, UQCRC1, COX7B2, NDUFA13 |
GO:0005747 | CC | mitochondrial respiratory chain complex I | A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. |
NDUFS8, NDUFA4, NDUFAB1, NDUFA1, NDUFS4, NDUFA2, NDUFS2, NDUFS6, NDUFB6, NDUFB4, NDUFB8, NDUFA7, NDUFA10, NDUFB10, NDUFB7, NDUFV2, NDUFS1, SNCA, NDUFV3, NDUFA5, NDUFA11, NDUFB11, NDUFA13 |
GO:0005749 | CC | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) | A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. |
SDHB, SDHA, SDHC |
GO:0005750 | CC | mitochondrial respiratory chain complex III | A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. |
PMPCB, UQCRB, UQCRC2, UQCRC1, UQCRFS1, UQCC3, UQCR10, BCS1L |
GO:0005751 | CC | mitochondrial respiratory chain complex IV | A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). |
NDUFA4, COX5B, COX6A1, COX5A, NMES1 |
GO:0005753 | CC | mitochondrial proton-transporting ATP synthase complex | A proton-transporting ATP synthase complex found in the mitochondrial membrane. |
ATP5H, ATP5L, ATP5J, ATP5D, PPIF, ATP5C1, ATP5O, ATP5G3, ATP5E, ATP5I, ATP5G2 |
GO:0005757 | CC | mitochondrial permeability transition pore complex | A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D). |
BAX |
GO:0005758 | CC | mitochondrial intermembrane space | The region between the inner and outer lipid bilayers of the mitochondrial envelope. |
HAX1, NME4, TIMM23, TRIAP1, OPA1, AIFM1, LYN, FGR, HSD3B1, COX6B1, NDUFB7, DTYMK, HSD3B2, NDUFS1, CPOX, STAR, GATM, SUOX, THOP1, GFER, CMC4, BLOC1S1, CYCS, COX17, COX19, THEM4, MICU2, PNPT1, CHCHD10, CEP89, UQCC2, CHCHD5, CHCHD7, PINK1, NLN, PANK2, TXNIP, SDHAF3, COA4, PRELID1, REXO2, TIMM10B, CHCHD2 |
GO:0005759 | CC | mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
TK2, NDUFS8, NME4, NDUFAB1, KIAA0391, PRODH, IDH3B, PTCD1, NDUFS2, PMPCB, CLPX, GLS, NDUFA10, FARS2, ETHE1, GSR, GOT2, NR3C1, SOD2, TP53, TYMS, ALDH2, CYP11A1, PCCA, GPX1, FH, PDHA1, DLD, FDX1, DLAT, HSPD1, PDHB, DBT, PC, BCKDHA, MTHFD2, CREB1, AGXT, BCKDHB, ME2, GCSH, DTYMK, AK4, NDUFS1, ATP5D, ECHS1, PPIF, ALDH1B1, HIBADH, HSPA1L, HMGCL, ATP5C1, NUDT1, DLST, MDH2, ECI1, TSFM, ACADSB, IDH2, ALDH7A1, HARS2, ACADVL, MTHFS, SUOX, SUCLG1, ATXN3, OXCT1, ATP5E, ABCE1, HSPE1, BLOC1S1, ABAT, TFAM, OGDH, ALDH6A1, SSBP1, RNASEL, RAD51, C1QBP, MCL1, PMPCA, COASY, AUH, ICT1, FASTK, LARS2, KARS, PDK1, ERBB4, ETFDH, FXN, PDK4, DECR1, CLPP, HAGH, ME3, PCK2, HADH, DGUOK, TRMT5, ALDH1L2, ACSM3, LACTB2, EARS2, PITRM1, THEM4, PDSS1, IBA57, SDHAF4, HIBCH, FDX1L, MTHFD1L, PARS2, PDSS2, PHYKPL, MMAA, CARKD, ADHFE1, ETFBKMT, SUPV3L1, CCAR2, PPM1K, GUF1, GADD45GIP1, NUBPL, GPT2, MALSU1, MMAB, PRIMPOL, MCEE, TRNT1, TEFM, GFM1, MCCC1, PEO1, MTERF1, HSD17B10, TXN2, MIPEP, ACO2, ELAC2, UQCC2, MTG1, ALKBH7, ISCA1, NUDT9, PPA2, MTG2, DUSP21, MTHFD2L, GRPEL1, MCCC2, SDHAF3, GLRX2, ACSS1, ABHD10, COQ3, PDP1, SUCLA2, AASS, DMGDH, AK3, SARDH, DIMT1, LIPT1, PIN4, GSTK1, ACOT9, REXO2, PAM16 |
GO:0005760 | CC | gamma DNA polymerase complex | A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA. |
DNA2, POLG |
GO:0005761 | CC | mitochondrial ribosome | A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. |
MRPS12, MRPS14, NDUFA7, MRPL51, GADD45GIP1, CHCHD1, MRPL48, MRPL34, MRPL57, MTG1, MRPL32, MRPL37, MTG2, MRPL40, MRPL35 |
GO:0005762 | CC | mitochondrial large ribosomal subunit | The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). |
MRPL33, MRPL19, MRPL12, ICT1, MRPL23, MRPL51, MRPL21, MRPL55, MRPL52, MRPL41, MRPL32, C12orf65, MRPL47, MRPL17, MRPL16, MRPL15, MRPL36 |
GO:0005763 | CC | mitochondrial small ribosomal subunit | The smaller of the two subunits of a mitochondrial ribosome. |
MRPS12, MRPS14, DAP3, MRPS5, MRPS36, MRPS21, MRPS31, MRPS26, MRPS18A, MRPS28, MRPS2, MRPS18B, MRPL42 |
GO:0005764 | CC | lysosome | A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
TMEM150B, RNASET2, TPP1, NPC1, STX7, RAMP3, VAMP4, CLN5, BCL10, ADA, ASS1, CST3, LDLR, IL1B, HLA-DRA, MPO, CTSD, ADRB2, PSAP, CTSL, CTSB, STS, CTSH, RNASE2, GAA, LAMP1, ACE, LAMP2, HLA-DOB, TYR, ARSA, ARSB, IFNAR1, GJA1, TNFAIP3, CTSS, PRDX6, USP6, SNCA, LIPA, CTSK, SLC11A1, TSC2, LRBA, PPT1, RAB7A, RAB9A, RAB27A, SGSH, ARSD, CTSC, NAGLU, GALC, SNX16, CXCR4, NPC2, LRP2, CTBS, CD164, HYAL2, ANK3, CHIT1, CLN3, LAPTM5, NBR1, TRIP10, TMEM97, MARCH8, LAMTOR1, RAB12, DRAM2, KIAA1324, TMEM150A, DRAM1, RNF152, PCSK9, SLC38A9, FLCN, ENGASE, TPCN2, WDR48, MARCH1, GLMP, ABCA5, GGH, HPS1, ARRDC3, C9orf72, CCDC115, ANKRD27, FNBP1, NEU1, SYT11, BBC3, TMEM59, AP5M1, RRAGC, ATP13A2, HPS4, RRAGD, TMEM9, CTSZ, CTSF, PCYOX1, EPDR1, PPT2, HPSE, AP3M1, MYO5A, CPQ |
GO:0005765 | CC | lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
TMEM150C, AP3D1, ABCD4, NPC1, STX7, TLR3, GPR137B, ATP6V1G1, CLN5, FLOT1, TMEM63A, SNAPIN, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, ANXA2, PSAP, ANXA6, HSP90AB1, GNAI3, GAA, LAMP1, IGF2R, COL6A1, LAMP2, CFTR, HLA-DRB4, HLA-DOB, ACPP, CD1D, HLA-DPA1, ATP6V1B2, ATP6V1C1, UBA1, ENPP1, DPP4, HLA-DMB, GNA11, CD68, TRIM23, ECE1, NSF, SLC11A2, PSEN1, GNAQ, RAB5C, RAB7A, CLCN5, CLCN6, CLCN7, VAMP7, AP1S2, RAB2A, ATP6V0D1, AP1S1, GNB1, GNB2, UBA52, GNAI1, BLOC1S1, HLA-DRB3, GPLD1, DAB2, LRP2, IFITM3, CD164, AHNAK, AP1B1, CLN3, PLD1, TCIRG1, LAPTM5, STARD3, RHEB, MMD, HLA-DRB5, MARCH8, ABCC10, HGSNAT, LAMTOR1, RAB12, TLDC1, DRAM2, KIAA1324, SLC36A1, TECPR1, SLC26A11, OSTM1, SLC44A2, DRAM1, SLC15A4, RNF152, SLC38A9, DAGLB, ATP6V1C2, MFSD8, TPCN2, MARCH1, SPPL3, SPPL2A, HM13, SCARB1, GLMP, ABCA5, TMBIM1, BORCS7, ARL8A, AP2M1, BORCS6, VPS35, NEU1, P2RX4, LITAF, TMEM59, OSBPL1A, WDR11, TM6SF1, AP5M1, TMEM165, TMEM8A, GOPC, ATP13A2, TMEM106B, LMBRD1, ARL8B, TMEM9, ANKFY1, VTI1B, LAMTOR3, ATP6V1H, LNPEP, MYO6, LAMP3, HPSE, LAMTOR2, AP3M1, ATP6V1D |
GO:0005768 | CC | endosome | A vacuole to which materials ingested by endocytosis are delivered. |
DSCR3, ARPC2, LEPROT, STX7, RAB11FIP3, PDCD6, VPS4B, VAMP4, VPS26A, RASSF9, PAK3, FLOT1, MYO1D, EGFR, NGF, TFRC, ANXA1, NTRK1, APP, FYN, ANXA2, ADRB2, NGFR, STS, HMGB1, IGF2R, ACE, EZR, FOLR1, RAB5A, MAL, S1PR1, LHCGR, CDK2, AVPR2, CLIP1, GPC1, TGFBR1, ADCYAP1R1, PRKCI, NSG1, ECE1, CRKL, CDKN1B, ATP1A2, CLCN5, RAB5B, RHOA, TGFB2, GRB2, LRP2, CAV1, CD164, TNK2, STX4, PLD1, RAPGEF1, KCNJ11, RFTN1, RABEP1, PKN1, WDR72, OCIAD2, TJAP1, MARCH8, STEAP4, RAB11FIP2, ARC, RABEPK, DGKH, ARRDC4, EXPH5, MARCH1, FRS2, SNX33, SORL1, ARRDC3, SYTL4, C9orf72, CCDC115, VPS35, SNX18, TM9SF2, ZFYVE21, PACSIN1, CHMP4B, ABCB6, OCIAD1, BET1L, PI4KB, SPAST, VPS29, SCOC, RAB21, BLOC1S6, ANKRD50, SNX9 |
GO:0005769 | CC | early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
WASH1, NEURL1B, RHOD, NRP1, RAB29, STX7, TLR3, SIAH2, STX6, TRAK2, SNX3, DIAPH2, ATP9A, VPS26A, LRP6, FLOT1, STAMBP, LDLR, CD4, APOA1, APOE, APOA2, APOC3, TF, APOB, NTRK1, ANXA2, ADRB2, ADRB1, HSPD1, IGF2R, CFTR, GJA1, VCAM1, RAB5A, F2R, MAPK3, MAPK1, EPHA3, CORO1A, AKT2, PHB, NF2, MAP2K2, SLC11A2, NUMB, RAB5C, CLCN3, F2RL1, SNX16, RAB5B, CXCR4, ATP6V0D1, RHOB, RAB1A, RAP1A, OCRL, MAP2K1, NUCB1, PTP4A2, CLN3, RAB31, RAB32, RAPGEF1, EEA1, RABEP1, AOC3, HFE, CCDC93, RABGAP1L, LDLRAP1, WLS, PARM1, ZFYVE16, SIAH1, VPS8, COMMD1, NIPA2, PCSK9, ARRDC4, DNER, RIN3, TBC1D16, SORL1, PTP4A1, MIB2, ARRDC3, SGK3, ANKRD27, ALS2, VPS35, GPER1, KIFC1, DERL2, ACKR4, ANKFY1, VPS29, RABGEF1, RAB22A, SNX12, TRAK1, LAMP3, ATP11B, NISCH, CCDC53, MYO5A, LIPG, WASF2 |
GO:0005770 | CC | late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
WASH1, STX7, SLC31A1, SLC31A2, LDLR, TF, NTRK1, LAMP1, IGF2R, LAMP2, IFNAR1, F2R, MAPK3, MAPK1, DDIT3, MAP2K2, HTT, SLC11A1, RAB7A, RAB9A, RAB27A, CLCN3, SNX16, CXCR4, RAP1A, ARF1, MAP2K1, CLN3, MTM1, SQSTM1, NBR1, PARM1, KIAA1324, MAGI2, ANKRD13A, PCSK9, SLC38A9, PIK3C3, WDR48, SPPL2A, RNF128, ABCA5, SLC9A6, ANKRD27, VPS35, PIK3R4, SDF4, TMEM59, OSBPL1A, DERL2, AP5M1, MAP1LC3A, ATP13A2, TMEM9, VPS29, RAB22A, KIDINS220, LAMTOR2, MYO5A |
GO:0005771 | CC | multivesicular body | A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
CST3, CD74, LAMP1, TPT1, SLC2A4, GJA1, ZP3, RAB11A, BST2, SLC40A1, ATP13A2, HDAC6 |
GO:0005773 | CC | vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
CD74, SLC11A2, STX4, NPRL3, STX3, GLB1L2, GGH |
GO:0005774 | CC | vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
RAB7A, NAPB, TMEM138, PCYOX1 |
GO:0005776 | CC | autophagosome | A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy. |
WASH1, TBC1D12, ULK1, IL1B, RALB, HTT, GABARAPL2, PIP4K2B, CALCOCO2, CLN3, SQSTM1, NBR1, RAB12, TP53INP2, TBC1D5, TP53INP1, OPTN, NRBF2, C9orf72, PIK3R4, MAP1LC3B, PEG3, GABARAPL1, MAP1LC3A, ZFYVE1, ATP13A2, UBQLN4, TBC1D14, RAB23 |
GO:0005777 | CC | peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
AGPS, PEX12, ABCD4, GNPAT, ACOX3, SLC25A17, PEX14, IDH1, TRIM37, PEX11B, VIM, NUDT7, IDE, AGXT, SCP2, ABCD3, TKT, HMGCL, MPV17, CRAT, XDH, IDH2, HSD17B4, HRSP12, PEX3, ECH1, IDI1, ACOX1, ACBD5, HSDL2, TMEM135, LONP2, ZADH2, ACOT4, GBF1, FAR2, ACOX2, DHRS4, IDI2, MFF, PNPLA8, HAO2, PIPOX, AKAP11, CROT, GSTK1, KIAA0430, MYO5A |
GO:0005778 | CC | peroxisomal membrane | The lipid bilayer surrounding a peroxisome. |
AGPS, PEX12, ABCD4, SLC27A2, GNPAT, SLC25A17, ACSL4, PEX14, PEX11B, HMGCR, MGST1, ABCD3, ACSL1, MAP2K2, ALDH3A2, HSD17B4, PEX3, ARF1, ACOX1, TMEM35, ACBD5, MAVS, ATAD1, RAB8B, FAR2, TTC1, DHRS4, PNPLA8, ACSL6 |
GO:0005779 | CC | integral component of peroxisomal membrane | The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
PEX12, SLC27A2, SLC25A17, PEX11B, PEX3 |
GO:0005782 | CC | peroxisomal matrix | The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. |
NUDT19, AGPS, ACOT8, GNPAT, ACOX3, ECI2, IDH1, NUDT7, HSPD1, IDE, AGXT, SCP2, ABCD3, CRAT, HSD17B4, ACOX1, LONP2, ACOT4, FAR2, ACOX2, HAO2, PIPOX, GRHPR, CROT |
GO:0005783 | CC | endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
TMEM129, ELOVL7, KIAA0922, HAX1, RNF103, PLOD2, SCD, TOR1A, HSD17B6, MGST3, CLGN, PDZD2, NPC1, GPR37, P4HA2, INSIG1, HNRNPR, ATP8B1, SLC37A4, CALU, KIF1C, BNIP3L, PLIN1, PARK2, BRINP1, SYNCRIP, TPST2, ICMT, LRP5, PDCD6, MPDU1, ERN1, CLN5, LRP6, CRTAP, PPP1R15A, TRAPPC6A, ARL6IP5, STC2, TM7SF2, PDE9A, SRP72, ERLIN2, SEC31A, NDUFB8, VAPB, PSMG1, STAU1, TMEM50A, CYB5R3, ASS1, SERPINA1, CST3, FOS, HLA-B, APOE, APOC1, ALB, HMGCR, PRNP, VWF, TP53, APOD, CYP17A1, DBI, P4HB, THBS1, ITGA5, STS, HMOX1, FURIN, TRAPPC2, BCL2, MGST1, CYP2D6, TFPI, CLU, HSPA5, CYP19A1, P4HA1, PRKCSH, PLA2G2A, HSP90B1, POU2F1, IFNGR1, ATP2A2, PRKCA, PTPN2, XBP1, ATF6, VCAM1, CAST, MAL, ZP3, TGM2, PPIB, EEF1B2, HSD3B2, PLN, FKBP2, STOM, RPL10, CALR, CANX, PCSK6, EEF1D, ERP29, PDIA3, MIP, HLA-A, HLA-F, AVPR2, LRPAP1, ADORA1, S100A7, MAN1A1, PTGS2, THBS4, SOAT1, CHI3L1, MAP2K2, FDFT1, IFNGR2, DDOST, ANP32A, HTT, CRAT, SSR1, CASP4, TMED10, PSEN1, PSEN2, EMD, SERPINH1, LRBA, BCAP31, RAP1GDS1, PLA2G16, EPHA4, VCP, HADHB, TPD52, TMEM50B, PEX3, NPC2, RRAS2, DLG4, SLC35A2, NUCB2, TMF1, LRP2, SET, COL4A3, MAP2K1, CAV1, PRKCD, BAX, KCNA1, SREBF2, ASPH, GRIN2A, HYAL2, ANK3, DLG1, BNIP3, ARHGAP5, SEMA3B, DNAJC3, CLN3, PDE3B, SLC39A6, SQSTM1, PKD2, RAB32, MLEC, RCN2, PIGH, ITPR3, ITPR1, KCNJ11, EMC2, SLC39A14, RRS1, PDIA6, EBP, RCN1, TMED2, DHCR24, PUM3, SEC23A, NSDHL, MSMO1, ADIPOQ, EXT1, PTGIS, CYP51A1, AOC3, CPEB4, TMEM132A, PGS1, CCDC88A, CERKL, GPAT3, ORMDL2, HS1BP3, MEST, PIGG, CDKAL1, HACD4, ATL3, MCTP1, PTRF, SLC27A1, TXNDC11, CBLN3, CRELD2, HACD2, CERS6, IKBIP, PGAP1, SV2A, FA2H, LPCAT2, EPM2AIP1, SLC36A1, TMC6, GRINA, SYVN1, MTDH, GPAT4, KTN1, SGMS1, SLC26A11, ERO1B, TRAPPC5, P3H2, SULF2, SULF1, SGPP2, DNAJC10, MSRB3, HACE1, ZDHHC14, ABI1, GPC2, CRIPAK, UBE2J2, PHTF2, CERS5, CISD2, POMGNT2, SUMF1, PCSK9, SLC38A9, ATL2, KCNG3, FIBIN, STT3B, HM13, MRAP, AGR3, TRPM4, RNF128, RHBDD1, CEMIP, ZFAND2B, APH1B, SELM, PIEZO1, EDEM1, SORL1, KIFAP3, CDS1, EXT2, PTP4A1, MR1, TMEM203, CCDC47, CREB3L1, APH1A, FAF2, YIPF6, MRAP2, VMP1, ERO1A, VCPIP1, DNAJC1, DHRS1, DGAT2, SMIM14, PANX1, SRPK1, GPX7, SEC62, GPER1, PLIN2, PKMYT1, CHP1, SIGMAR1, MGST2, OLFM1, CIB1, VIMP, CCDC3, INPP5K, ELOVL1, EBPL, SCAPER, PLA2G12A, EDEM3, DERL2, ELOVL4, GABARAPL1, TMX4, EHD4, TOR3A, ELOVL6, FNDC4, ZDHHC6, YTHDC2, ALG9, METTL7A, PLEKHF2, REEP1, CERS4, ZFYVE1, APMAP, ABCB6, CD320, RTN4, MAN1C1, AGPAT3, STAU2, UFSP2, NDFIP2, TMEM30A, CLN6, SMPD4, ELOVL5, UGGT1, ERAP1, HACD3, VAPA, STIM2, RRBP1, ADAMTS9, DPM3, DHCR7, SPAST, CTSZ, DNAJB9, SEL1L, SEC63, USP25, ZDHHC2, MAN1B1, DSE, NRXN1, PYCARD, TMCO1, PHTF1, BOK, STUB1, ANGEL1, MINPP1, POMP, CNPY2, ATP11B, ZDHHC9, GOLT1B, TMED3, MYO5A, HYOU1, TBL2, PCDHA2, PCDHA1, TRAPPC1, IER3IP1, CPQ, POMT1, SLC30A1 |
GO:0005784 | CC | Sec61 translocon complex | A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events. |
SSR4, BCAP31, ARL6IP1 |
GO:0005785 | CC | signal recognition particle receptor complex | A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex. |
SRP9, RP9, SRPRB |
GO:0005786 | CC | signal recognition particle, endoplasmic reticulum targeting | A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. |
SRP72, SRP14, SRP9, SRP54 |
GO:0005787 | CC | signal peptidase complex | A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. |
SPCS2 |
GO:0005788 | CC | endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
RNASET2, TOR1A, SLC27A2, P4HA2, SELENOF, CRTAP, H6PD, F8, F2, SERPINA1, PDGFB, GCG, INS, CD4, COL1A1, COL3A1, APOA1, APOA2, BGLAP, PDGFA, APOB, COL5A2, P4HB, THBS1, COL1A2, COL4A2, STS, HSPA5, COL11A1, COL6A1, COL6A2, COL6A3, F5, PDIA4, P4HA1, COL11A2, PRKCSH, HSP90B1, ARSA, ARSB, COL9A1, COL5A1, PPIB, COL8A2, COL5A3, CALR, CANX, CFP, ERP29, PDIA3, PTGS2, COL15A1, COL18A1, WNT5A, SERPINH1, ARSD, CTSC, WNT3, B2M, COL4A3, PLAUR, COL10A1, COL14A1, COL16A1, DNAJC3, OS9, COL4A6, RCN2, GAS6, PDIA5, GANAB, PDIA6, RCN1, TOR2A, COL13A1, ERAP2, KDELC1, CES3, ARSK, ADAMTSL4, KDELC2, COL23A1, P3H2, DNAJC10, TOR2A, SUMF1, CYP2W1, GPX8, GBF1, MYDGF, FKBP10, ERO1A, COL21A1, GPX7, COL12A1, ERP44, CNPY3, TMEM43, EDEM3, PDGFD, WNT5B, TOR3A, SPON1, PDGFC, FKBP14, CLN6, UGGT1, ERAP1, CTSZ, DNAJB9, GHRL, ADAMTS7, COL17A1, ADAMTS5, MINPP1, HYOU1, FKBP7, WNT6 |
GO:0005789 | CC | endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
TMEM129, ELOVL7, TMEM189, HACD1, RNF103, WRB, SLC33A1, PLOD2, SDCBP, SCD, COPE, GOSR2, ABCD4, PTGES, MGST3, CLGN, SLC27A2, SURF4, SPTLC2, GRM6, GPR37, TLR3, INSIG1, FLRT2, CYP26A1, ASNA1, KDELR3, SLC37A4, CALU, AHCYL1, FADS1, ACSL4, ICMT, TRIM13, PDCD6, MPDU1, SEC22B, ERN1, PPP1R15A, SC5D, DHRS3, ARL6IP5, TM7SF2, SEC24D, TMCC1, ERLIN2, SEC31A, CLSTN1, CSPG5, VAPB, CTDNEP1, ABCA1, CDS2, FADS2, CH25H, CYB5A, CYB5R3, EGFR, TGFA, CD4, HMGCR, APOB, CYP1A1, CYBB, CYP17A1, CYP2E1, UGT2B4, EPHX1, CYP3A4, CYP21A2, STS, HMOX1, UCHL1, BCL2, MGST1, CYP2D6, HSPA5, CYP2A6, CYP19A1, SFTPC, CYP2C9, PSKH1, HSD3B1, PLA2G2A, HSP90B1, FOLR1, AREG, CD1D, ATP2A2, GJA1, XBP1, SRD5A1, ATF6, CYP2B6, CYP3A5, OSBP, AADAC, PTGS1, KDELR1, CYP3A7, HSD3B2, FKBP2, CANX, HSD11B1, SRI, SRD5A2, FMO4, ACSL1, PTGS2, G6PC, SOAT1, GJC1, SREBF1, HSD17B2, FDFT1, PIGA, GGCX, IFNGR2, DDOST, PMEL, PTGDS, TMPO, TMPO, SSR1, NOTCH1, STT3A, PLA2G4A, ARCN1, LSS, PTDSS1, PITPNB, PCYT1A, CASP4, TMED10, PSEN1, PSEN2, RAB9A, BCAP31, ALDH3A2, VAMP7, COPA, ATXN3, VCP, SEC13, HSD17B7, ANTXR2, SEC61G, CDC42, RAB2A, RHOA, DAD1, COPZ1, RAB1A, RAC1, EIF5A, PIP4K2B, HSD11B2, FKBP3, FKBP4, PLOD1, DST, CAV1, PLAUR, NOTCH2, TYRO3, PIGF, BAX, DMPK, GALNT2, GALNT1, SREBF2, ASPH, LRMP, DLG1, PLD1, OS9, FKBP5, PKD2, MLEC, PIGH, NFE2L1, SQLE, PDIA5, ITPR2, ITPR3, ITPR1, LPIN1, SPCS2, ARL6IP1, RAB3GAP1, PDIA6, EBP, TMED2, RHEB, DHCR24, SEC23A, NSDHL, MSMO1, EXT1, PTGIS, CYP1B1, CYP51A1, DUOXA1, DUOXA2, TMEM132A, PIGY, TMEM259, GPAT3, HSD17B12, TTMP, MEST, PIGG, ALG10B, WLS, CDKAL1, ATL3, REEP3, ERAP2, LPCAT3, SLC27A4, LRRC8B, TXNDC11, AGTRAP, MOXD1, SHISA2, LCLAT1, SEZ6L2, CYP2R1, HACD2, CERS6, CYP4V2, MBOAT2, IKBIP, ILDR2, PGAP1, FA2H, LPCAT2, ERMP1, TMC6, CYP2U1, PIGW, TMED4, SCD5, SYVN1, MTDH, GPAT4, KTN1, SLC51A, ANKLE2, ERO1B, GPSM1, SGPP2, RDH10, ARMC10, UBE2J2, CERS5, CISD2, MFSD2A, POMGNT2, TMEM178A, SVIP, ATL2, MCFD2, CYP2W1, ABHD4, PIGX, DNAJB14, RDH11, MARCH1, HM13, MRAP, LRRC8C, RHBDD1, NUP210, RAB2B, TMEM170A, PIEZO1, PIGC, SLC9A6, LPGAT1, PIGK, CDS1, EXT2, MR1, YIPF5, PIGT, TMEM203, NCLN, ERGIC1, PNPLA2, FKBP10, CREB3L1, APH1A, RHBDF1, MRAP2, ERO1A, SEC22A, SEC16B, FAR2, DNAJC1, CARD19, MBOAT7, NECAB3, DGAT2, NOX5, SMIM14, PANX1, ERGIC2, LMF1, SEC62, PCYT2, SDF2, FMO2, GPER1, PKMYT1, MGLL, SIGMAR1, MGST2, DHRS9, VKORC1, APOL2, ERP44, DHRS4, G6PC3, APOO, ALG8, TMEM106C, ELOVL1, TAPBPL, EBPL, SEC11C, OSBPL8, OSBPL6, EPT1, LNP, DERL2, EIF5A2, RAB1B, LMAN2L, XYLT2, HSD3B7, RAB3GAP2, PIGU, CLSTN2, ELOVL6, ZDHHC6, ALG9, RNF121, SEC61A2, CERS4, SLC28A3, CYP3A43, GBA2, ABCB6, ALG13, PNPLA8, NOX4, RTN4, CYP26B1, UBQLN4, SERINC1, AGPAT4, AGPAT3, PNPLA3, SLC35D1, FKBP14, CLN6, SMPD4, FKBP11, ELOVL5, ERAP1, FMN2, FLRT3, FLRT1, SEPN1, JKAMP, VAPA, STIM2, DPM3, PEMT, DHCR7, SPAST, DNAJB9, SEL1L, VTI1B, SEC63, MAN1B1, C14orf1, ACSL6, AMFR, RAB21, NDRG4, BOK, SSR3, CYP8B1, PLA2G4C, MAPK8IP1, RCE1, ERGIC3, MYRF, ZDHHC9, TMED5, RTCB, TMED3, PCYT1B, SRPRB, IER3IP1, ALG6, COPG1, FKBP7, POMT1, SAR1B, CEPT1 |
GO:0005790 | CC | smooth endoplasmic reticulum | The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. |
MYO1D, APP, TH, HSPA5, PPIB, CALR, CANX, ERP29, SRI, PSEN1, PRDX4, DNAJC3, SLMAP, RYR3, SYVN1, RYR2, GBA2, MAPK8IP3, HYOU1 |
GO:0005791 | CC | rough endoplasmic reticulum | The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. |
STAU1, BGLAP, CYBB, APP, HSPD1, CCL2, ARSB, CA4, MT3, CANX, SNCA, PTGDS, ADCYAP1R1, PSEN1, EPHA5, SEC61A1, NUCB1, TRAM2, TMEM97, CDKAL1, PCSK9, SPPL3, HM13, CCDC47, SEC62, FKRP, LIN28A, RANGRF, SLC7A11 |
GO:0005793 | CC | endoplasmic reticulum-Golgi intermediate compartment | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. |
SURF4, SEC22B, STK17B, FN1, P4HB, HMGB1, HSPA5, PTPN2, CA4, KDELR1, MAN1A1, TMED10, SERPINH1, IST1, NUCB2, NUCB1, PDIA6, TMED2, RGMB, GBF1, MYDGF, ERGIC1, SCYL1, CCDC115, CHP1, ERP44, LMAN2L, SLC35C2, RAB6B, UGGT1, DICER1, TMED5, TMED3 |
GO:0005794 | CC | Golgi apparatus | A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
GOLGA8A, HIP1, IPO5, PIK3C2A, GOLIM4, BTN3A3, PLPP3, BHLHE40, COPE, AP3D1, GOSR2, ADAM10, RAB29, NPC1, SCAMP2, ARPC2, PLSCR1, LEPROT, HDAC3, AKR7A2, B4GAT1, ATP8B1, SPRY1, ITM2A, STX6, CALU, KIF1C, PARK2, ADCY3, TPST1, NMT2, TLR2, TPST2, DIAPH2, FAM20B, OBSL1, VAMP4, CLN5, STX11, LRP6, RP2, SCRG1, PPP1R15A, AP1G2, STC2, PDE9A, ZFPL1, CSPG5, KIF20A, TNKS, VAPB, SNAPIN, PSMG1, LARGE, ABCA1, CXCL14, SERPINA1, NRAS, LDLR, HLA-B, COL1A1, CRYAB, APOE, ALB, ESR1, RAF1, APOB, PRNP, CYBB, APP, DBI, GALT, LYN, CD14, ITGA5, GNAI3, STS, SRGN, HSPD1, CLU, PSKH1, PTHLH, BMP1, B4GALT1, ARSB, CD44, CD36, CPE, GJA1, SYN1, TCP1, ARF4, ATF6, LIG1, VCAM1, FUT1, CCNA2, SYT1, ZP3, FGF7, FGFR2, OSBP, FUT4, GAL, CA4, XPA, PTGS1, IGFBP6, F2R, MAPK3, CALR, MAPK1, CTGF, HLA-A, AVPR2, GDI1, STIP1, MAN1A1, CTNNA1, MAP2K2, PPARG, SNCA, PLA2G5, PMEL, ID1, AQP2, PTGDS, HTT, PLA2G4A, ARCN1, SLC1A6, CSNK1D, TGM4, FASN, PSMB3, TMED10, PSEN1, PSEN2, TSC2, GDI2, ERF, LRBA, RNF144A, PPT1, RAB7A, RAB27A, CAV2, CLCN3, MSH6, AP3M2, EPHA4, EMP2, F2RL1, AP1S2, AP3S2, GABARAPL2, ZP1, B2M, AP1S1, NCS1, RAB11A, RAB1A, GRB2, DYNLT1, SLC35A2, SLC35A1, NUCB2, TMF1, ARF5, LRP2, ATP2C1, APBA1, SP3, MAP2K1, NUCB1, ICA1, GOLGA2, MGAT2, GALNT2, GALNT1, BST2, FUT2, ANK3, DLG1, STRN3, CLN3, PDE3B, PLD1, GOLGA4, PICALM, SNX1, PWP1, PTCH1, CUX1, CDK13, CTTN, NEDD9, GANAB, CUL7, NAA25, RAB3GAP1, SLC39A14, PRKD1, TMED2, TLR1, TAF11, MMD, TRIP11, MAPRE1, SLC1A5, EXT1, AOC3, TMEM132A, GNPTAB, CCDC88A, GLYR1, CERKL, LARP7, PREPL, ESCO2, WDR44, RABGAP1L, MANEA, ARHGAP21, WLS, GKAP1, PDE4DIP, GLT8D1, LAMTOR1, AFTPH, CBLN3, PARM1, DRAM2, CRELD2, FGD6, BEND5, TMC6, GRINA, CCDC91, FGD2, SERINC5, CAND1, HOOK3, SLC26A11, CEP57, ZDHHC17, HID1, P3H2, ARL17A, SULF1, FAM20C, SCYL3, XRN1, MAML2, VPS52, NLGN1, ASCC3, GALNT4, MINK1, ARFGAP2, GOLM1, PCSK9, TNRC6A, GLIS3, USP32, SGMS2, FIBIN, MPLKIP, SLC35G2, BICD2, TRPM4, PXYLP1, RNF128, ATP8B4, SECTM1, SELM, SEC14L1, FAM3C, GBF1, TOPBP1, SORL1, KAT6A, GOLGA1, PCSK5, RPGR, KIFAP3, GLG1, ARHGEF2, ATP6V0A1, EXT2, TMBIM1, JAKMIP2, APH1A, OPTN, RAB39B, C11orf24, PERP, BICD1, SCYL1, FGD4, ARAP1, PASK, ERGIC2, LMF1, OSBPL9, GPER1, MPHOSPH9, PKMYT1, FEZ1, LITAF, CDC6, CIB1, ARID3A, MAPKAP1, SOST, SDF4, TMEM43, PDCD10, DUSP26, TIPIN, JAM3, OSBPL11, FUT8, RAB34, PRKD2, PLA2G12A, SPRY4, CHST5, CHST6, ADAM19, GABARAPL1, RAB1B, LMAN2L, ACBD3, FZD8, DDX31, AKTIP, FKRP, TMEM165, CWC22, GOPC, ABCB6, ARFGAP3, SLC35C2, ASH1L, RAB6B, NDFIP2, TMEM30A, HAUS2, SMPD4, ZDHHC7, AATF, BET1L, STMN3, CLIC5, EHF, GRHL1, TBC1D14, STARD9, VTI1B, ZDHHC2, GNPTG, GGA2, GGA1, MAN1B1, MYH2, DSE, MTUS1, MYO6, PLAGL1, BOK, SYNRG, NDRG2, MACF1, HDAC5, ZNF148, AKT3, RUVBL1, ERGIC3, ITM2B, SLC35A3, ATP11B, CRYL1, AP3M1, ZDHHC9, TMED5, TMED3, TRRAP, MYO5A, CEP83, IER3IP1, LIPG, CPQ, COPG1, SLC30A1, DUSP10 |
GO:0005795 | CC | Golgi stack | The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. |
RAB27B, NSF, OCRL, MGAT2, GALNT2, CLN3, COG2, DNMBP, LPCAT2, SULF2, SULF1, GBF1, VCPIP1, VRK1, RAB34, ZFYVE1, NSFL1C |
GO:0005796 | CC | Golgi lumen | The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. |
AGRP, GOLIM4, NCAN, HS3ST1, SDC3, GPC4, CSPG5, F2, TGFB1, NGF, CGA, LHB, INS, BGLAP, VTN, DCN, SOD3, FURIN, DEFA4, VCAN, MUC1, SDC1, OGN, BGN, MMP11, PCSK6, SDC4, SDC2, GPC1, WNT5A, MMP14, MMP16, LUM, WNT3, MUC5AC, HSPG2, MUC3A, FMOD, PPIL2, GAS6, MUC21, CSPG4, GPC2, MUC20, MUC15, PCSK5, MUCL1, BCAN, MUC4, OMD, SDF4, WNT5B, BLZF1, MUC13, GPC6, WNT6 |
GO:0005797 | CC | Golgi medial cisterna | The middle Golgi cisterna (or cisternae). |
HID1, TMEM59 |
GO:0005798 | CC | Golgi-associated vesicle | Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. |
ADAM10, AP1G2, GNRH1, TYR, OCRL, NUCB1 |
GO:0005801 | CC | cis-Golgi network | The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. |
GOLIM4, RAB29, KDELR1, PIK3R1, CTGF, TMED10, LIMK2, NUCB1, GOLGA2, TRIP11, HOOK3, GBF1, YIPF6, SCYL1, SLC35C2, PHTF1, ANGEL1, TMED5 |
GO:0005802 | CC | trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
GSAP, RAB29, SCAMP1, STX6, ATP9A, SOD3, FURIN, IGF2R, PAM, CA4, LAP3, VAMP7, SNAP25, RAB11A, RAC1, AP2B1, VAMP2, ARF1, ATP2C1, OCRL, NUCB1, STX4, CLN3, GOLGA4, RAB32, POSTN, PRKD1, TGFBI, TRIP10, TJAP1, WIPI1, FNBP1L, WLS, DENND5A, CNST, KIAA1324, CHST4, PIFO, GBF1, SORL1, GOLGA1, OPTN, YIPF6, BICD1, ARAP1, FNBP1, GPER1, INPP5K, CHAC1, RBFOX1, SMPD4, SCOC, GGA2, RAB21, CHST2, SNX9, ARFGEF2 |
GO:0005811 | CC | lipid particle | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
PLIN1, ACSL4, CYB5R3, GAPDH, ANXA2, FABP4, ALOX15, G0S2, ALDH3B2, LSS, RAB5C, RAB7A, BCAP31, IRAK1, VCP, PLIN5, CAV1, LIPE, RAB3GAP1, NSDHL, LPCAT2, PNPLA5, SPG20, HSD17B11, ABHD4, ABHD5, GBF1, PNPLA2, ATG2B, FAF2, DGAT2, PLIN4, PLIN2, SIGMAR1, AIFM2, REPIN1, METTL7A, PNPLA3, SPAST, PRPF19, STARD13, HILPDA |
GO:0005813 | CC | centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
C4orf47, DCTN6, PLK4, ELL2, CHEK1, AURKA, PPP1R12A, ARHGEF10, SMAD7, CETN3, DYNC1LI2, WDR62, SSNA1, NUDT21, ROCK2, OBSL1, RAB11FIP3, VPS4B, USP2, OFD1, RAD51D, HAUS5, CEP152, CCNB2, PCNT, SNAP29, DDAH2, GNAI2, CDK1, NPM1, GNAI3, G6PD, PCNA, SKI, PRKAR2A, CCNB1, NME1, ZNF12, PRKACA, TCP1, MAK, TUBG1, CDK2, APC, MCM3, PSMA1, PSMB5, MARCKS, CDC27, CDC25B, CLIP1, PRKAR2B, CTNNB1, MDH1, ID1, ACTR1B, SLC1A4, RANBP1, CSNK1A1, CSNK1D, MAPKAPK2, CENPF, PSEN1, PSEN2, GSK3B, CCT8, BRCA2, NEK2, NEK3, PLK1, IST1, NUP107, ATP6V0D1, CALM2, RAB11A, GNAI1, DYNLL1, SKP1, CDK6, KIF23, ID2, PDE4D, CAMSAP2, MZT1, CCDC15, CDC20, DYNC1I2, XRCC4, UNC119, DCTN2, CKAP5, DCTN1, DYNC1H1, ESPL1, CHD4, CUL7, FAM175B, PCM1, STIL, MAPRE1, CCDC85B, PKN2, CSPP1, KIZ, ERCC6L, FAM161A, CCDC14, CEP55, ODF2, SGOL1, CEP78, CEP170, UBR4, CROCC, PDE4DIP, CEP135, TTC19, MZT2A, CCDC81, NEK10, HAUS6, PCGF5, SDCCAG8, HOOK3, CEP57, MIB1, BBS7, SIRT2, CKAP2L, CNTROB, AHI1, NIN, C7orf31, CEP120, POC1A, VPS37A, BBS1, CEP70, TTC8, MPLKIP, MDM1, POC1B, NEK9, FBF1, GSG2, CKAP2, PIBF1, IFT81, TOPBP1, NDRG1, RPGR, KIFAP3, MED12, CLUAP1, SYTL4, HAUS1, TUBGCP3, TBC1D31, HOOK2, MVB12A, ZNF274, MASTL, ZFYVE19, RITA1, MARK4, IFT74, CEP19, FOPNL, NEK1, ALS2, KIF20B, CEP89, MPHOSPH9, FEZ1, CIB1, HAUS7, NCAPG, SLF1, CCDC77, DCTN5, KATNB1, IFT27, SORBS1, LRRCC1, CEP44, NDEL1, SPATC1L, CCDC8, TSPYL2, IKZF4, RGCC, HAUS4, AUNIP, PHAX, TTC12, MEAF6, CENPJ, MKKS, CYLD, IFT46, MBNL1, KIF15, RAD18, DCAF13, RNF19A, HAUS2, MKS1, NDE1, AATF, PLK2, DTL, ITSN2, CAMSAP3, SLAIN2, WDR35, WRAP73, UXT, SPAST, FBXL7, NDRG2, CDC14A, PROCR, B9D1, USP20, RABGAP1, KIF3A, HSPB11, NME7, ATP6V1D, MAD1L1 |
GO:0005814 | CC | centriole | A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. |
WASH1, PLK4, AURKA, CETN3, WDR62, CEP104, OFD1, RP2, CEP152, PCNT, HSPA1A, HSPA1B, TOP2A, HSPA6, TUBG1, CAPG, CCNF, HTT, PCM1, STIL, CEP55, ODF2, CEP170, CROCC, CEP135, CEP128, SDCCAG8, SIRT2, CNTROB, AHI1, NIN, CEP120, POC1A, MDM1, POC1B, FBF1, TUBGCP3, WDR34, CEP19, CEP89, MPHOSPH9, LRRCC1, CENPJ, MKS1, PLK2, STARD9, WRAP73, TUBD1, TSKS, CEP83 |
GO:0005815 | CC | microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
NUDT21, SPAG9, BUB1B, RAB11FIP3, TACC1, DAB1, FLOT1, TACC2, LATS1, NR3C1, KRT18, G6PD, PSKH1, ATF4, MAPK1, SLC1A4, PPP4C, CDC42, RPS7, RELB, PTK2, RAD51, LRMP, MLLT11, RBM39, CASP8, SLMAP, DLGAP5, RAB11B, CSPP1, FAM110C, KLHL12, LRIF1, ERCC6L2, FRY, PPP4R3A, CCDC141, CEP128, CENPU, HAUS6, RBBP6, PXK, HOOK3, C2CD5, MCPH1, KIF18A, FAM110B, NEK7, PDCD6IP, NUDCD2, SPDL1, IFT43, AJUBA, BOD1, SCYL1, MARK4, RPP25, KIFC1, UBXN6, TRIOBP, TAF1D, NEK6, LATS2, RASSF1, CLIC5, FNIP2, LRWD1, AKAP11, MTUS1, NDRG2, EXOC7, RUVBL1, TLN1, LAS1L, ARFGEF2 |
GO:0005816 | CC | spindle pole body | The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome. |
MAP2K1 |
GO:0005819 | CC | spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
AURKA, MID1, BIRC5, PRC1, ZNF207, HAUS5, KIF20A, NR3C1, HSPB1, RB1, ERCC2, CDC27, AKT1, TTK, MYH9, CSNK1D, CENPF, ANXA11, KIF11, PLK1, TERF1, DYNLT1, CBX1, KIF23, MZT1, NSUN2, CDC20, MAP2K5, CBX3, SEPT6, NEDD9, SEPT2, RPS6KA2, MAPRE1, SEPT7, CSPP1, MAP7D1, CEP170, RIF1, MZT2A, PSRC1, MAEA, HAUS6, SIRT2, SHCBP1, GSG2, ARHGEF2, PTP4A1, TUBGCP3, AURKB, CHAMP1, HAUS7, VRK1, DIDO1, KIFC1, NUP85, NDEL1, HAUS4, ACOT13, CYLD, KIF15, FMN2, KLHL42, SPAST, FBXO5, MTUS1, TPX2, PRPF19, PIN4, INVS, FAM96B, SPIN1, MAD1L1 |
GO:0005826 | CC | actomyosin contractile ring | A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis. |
MYH9, MAEA, ANLN, MYH2 |
GO:0005827 | CC | polar microtubule | Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart. |
TUBG1, CUL3, TUBGCP3 |
GO:0005828 | CC | kinetochore microtubule | Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. |
KNTC1, RAB11A, KIF18A |
GO:0005829 | CC | cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
UBA6, CNOT1, FABP12, WIPF3, UNC119B, WASH1, BBIP1, ACOT7, MYO1C, AIP, RHOD, LGALS8, PSMD11, PSMD12, ATOX1, DFFA, PIK3CD, DCTN6, WASL, EML1, IGF2BP3, PIK3C2A, PLK4, EXOC5, KPNA3, SDCBP, KPNA4, TRIM38, PPP6C, FBP2, UBE2C, ACACB, PDXK, SOCS2, DPYSL4, SOCS3, ARHGAP33, DYNC1I1, COPE, CCS, GOSR2, IRS4, ITGB1BP1, RIOK3, MAP2K7, PDCD5, CHEK1, NDC80, NRP1, OPLAH, BACH1, IRF6, TAX1BP3, CASK, AURKA, RAB29, PPP1R12A, AZIN1, XPO1, PIP5K1B, ARHGEF10, SYNJ2, PFAS, ANKRD28, SMAD7, FYB, KPNA5, ARPC2, ARPC3, POLR1C, PLSCR1, AXIN1, SMAD9, GSTA4, KMO, NPHP1, MAPK13, OGT, PMM2, POLR3G, INPP4B, MID1, HDAC3, BIRC5, GYG2, NUPL2, CFLAR, SOCS1, PHGDH, ARHGAP6, IRAK2, DYNC1LI2, PSMD3, SIAH2, MAP3K7, EEF1E1, RIPK2, RASA4, SYNJ1, EIF4G3, AKR7A2, BCL2L11, FOXO3, SMAD6, AKAP10, SPRY2, SPRY1, CHMP2A, PRC1, RGS10, BUB1, BUB3, GSTZ1, CYTH3, STX6, SGTA, SSNA1, NRDC, AHCYL1, PDE6D, RAD21, PPP1R12B, BNIP3L, PLIN1, PARK2, SPAG9, PIP5K1C, SNX3, MGEA5, SORBS3, GMDS, NMT2, BUB1B, EIF4E2, EXOC3, PDE8A, JAK2, PRMT3, UGDH, CTNND1, PFKFB2, EIF5B, DIAPH2, DNAJA2, NBN, NOL3, WDR1, ROCK2, ATG13, RAB11FIP3, CNOT3, DNAJB6, HMMR, ATP6V1G1, VPS4B, FLNB, ULK1, VPS26A, PSIP1, SRSF10, GMNN, CLN5, BANF1, DAB1, SKAP2, PRKRA, CRCP, LYPLA1, OFD1, PPM1B, PPP1R15A, EIF3J, PSMD10, TRAPPC6A, IDH1, STAM2, TNFSF13, ALDH1L1, RASSF9, PAK3, PDE5A, PDE9A, BEST1, SRP72, DDAH1, ALDH1A2, ATG12, PLEKHG5, MYO1D, SEC24D, FARP2, GLS, HAUS5, RHOBTB3, TRIM37, AP2A2, SEC31A, CEP152, FAM13A, UPP2, CCNB2, MFN2, OAZ2, ZWINT, KIF4A, PDE8B, TNKS, PGLS, PAPSS2, SMC2, PARN, PCNT, DUS4L, CNOT4, NFATC1, ATP6V1G2, BAG2, CRYZL1, AIFM1, LATS1, DDAH2, NUDT3, CH25H, PTTG1, BCL10, CCNE2, ADH1B, LDHA, ALDH1A1, DHFR, GSR, PNP, PGK1, AK1, ADA, CA2, ASS1, A2M, FOS, MYC, KRAS, IL1A, IL1B, CRYAB, LMNA, APOA1, APOA2, RBP4, GC, FTL, FTH1, MT2A, RAF1, ALDOA, APOB, TK1, TUBB4A, GAPDH, TP53, HSPB1, TYMS, GNAI2, APP, S100A8, ISG15, PCCA, EIF2S1, RPLP1, RPLP2, RPLP0, JUN, FABP3, PRKCB, UROD, FYN, CDK1, S100A9, S100A6, EIF4E, ENO1, GPI, NPM1, TPM3, SERPINE2, TH, LDHB, GPX1, ANXA2, CA3, PFN1, BPGM, APRT, EPRS, HSP90AA1, GALT, HNRNPC, LYN, TPM2, FH, NGFR, HSP90AB1, ASNS, GSTA1, VIM, RPS17, RPSA, ENO2, GSTP1, QDPR, RBP1, FBP1, GSTM1, TPM1, CLTA, HMOX1, CTSH, FGR, ALOX5, UCHL1, ALDOC, UBC, TRAPPC2, SULT1A3, HSPA1A, HSPA1B, GLI2, GLI3, RAP2A, CCL3, AR, BCL2, TXN, MAPT, PRKAR1A, CD28, HSPD1, THRA, CLU, IRF1, PNMT, SLC2A1, UMPS, PYGM, BCR, LAMP1, FGFR1, G6PD, PC, DMD, MTHFD1, CDK4, ODC1, HARS, CKB, ACTN1, MYL4, XRCC5, CFTR, EEF2, ALAD, LCP1, TNNT1, GYS1, PRKAR2A, ENO3, HSD17B1, FDPS, PKM, HSP90B1, CCNB1, MYL6B, SLC2A4, SNRPB, TYR, IDE, DARS, JUP, FABP4, AKR1B1, RAC2, GSPT1, EZR, FOSL1, HPGD, VAV1, NME1, NQO1, RPS2, CHN1, ALOX15, PFKFB1, CBR1, GNB3, PLCG2, FAH, STMN1, HSPA6, RHOQ, HMGA1, PRKCA, GJA1, SYN1, PRKACA, DES, AMD1, CTPS1, PFKL, PSMC3, TCP1, RPL35A, ARF4, RPL7, RPL17, PGAM1, MYL12A, HK1, POLR2E, TNNI3, SRM, NFKB1, NCF2, TYMP, RAB3B, RAB5A, PSMB1, CAPN3, CAST, RASA1, PDC, PTMS, GSTM3, ATP6V1B2, ATP6V1C1, FLNA, TNFAIP3, SAT1, COMT, TGM2, OSBP, PCMT1, RPS4Y1, GART, PAICS, UBA1, NME2, CALB2, TUBG1, JAK1, AHCY, EIF4B, ITPKA, DTYMK, RRM1, IL32, CHM, EEF1B2, MYL9, CDK2, APC, MPST, FAS, DNAJB1, DNAJB2, MT3, PSMA1, PSMA2, PSMA3, PSMA4, CTNNA2, RPL13, CHML, TARS, ZFP36, MAPK3, RPL10, DCK, CAD, CALR, PIK3R1, PSMB8, PSMB9, PSMB4, PSMB5, GSTM2, ABCD3, TMOD1, MAPK1, TPP2, IMPA1, CTGF, EPHB2, TKT, CASP1, NOS3, LMOD1, EEF1D, PRDX6, BLVRB, RPL12, CMPK1, PEBP1, PPP2R1A, CDC27, CCND2, CDC25A, CDC25B, CDC25C, ADSS, ADSL, CLIP1, SRI, GSTT1, CORO1A, GDI1, S100A7, MAT2A, PRKAR2B, RRM2, DNAJA1, AKT1, AKT2, YWHAB, SFN, PRDX2, GK, DCTD, GBP1, GBP2, CTH, MCM7, SHMT1, HSPA1L, HSPA4, CTNNA1, CTNNB1, RPL22, CBS, PCK1, IRS1, AGL, MYH9, ACTN2, DDIT3, MYH11, GLRX, CHKA, PSMC2, MAP2K2, RPL4, NUDT1, PGM1, PPP1CC, SREBF1, GMPR, GPX4, SRP14, TGFBR2, PPARG, TALDO1, SNCA, CDKN1A, CCT6A, NNMT, PSMB10, ADH7, RPL13A, STAT3, MDH1, EIF2S3, RGS2, UBA7, CSK, MAP3K8, PRKCI, ACTR1B, STAT5A, AKR1C3, ARHGAP25, PIK3CA, PIK3CB, EPS15, RPS27, ABL2, RPL35, CDKN2B, CDKN2C, HTT, MTHFR, SYK, NAMPT, PSMC4, MAPK8, MAPK9, PHKA2, PHKA1, RANGAP1, CRKL, NSF, CDKN1B, NOTCH1, IER3, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, MAP1B, GNPDA1, YAP1, IQGAP1, PLA2G4A, CAPZB, EIF1AX, ALDH1A3, RPL29, ZFP36L2, XDH, LIMS1, ARCN1, GCLC, GCLM, CD151, TRAPPC10, CSNK1A1, CSNK1D, IDH2, PIK3CG, MAPKAPK2, ALDH9A1, RPL34, FASN, DHPS, CCT3, ALDH7A1, INPP1, CENPA, CENPF, SRP9, UBE2A, PCYT1A, SARS, PPM1F, CSNK1E, STAR, PSMB3, FHIT, RANBP2, RGS3, RGS4, RGS7, TSC2, GSK3B, MTHFS, GMPS, MRE11A, HNMT, GDI2, SERPINB9, ERF, METAP2, KNTC1, PPT1, RPL14, CCT8, RAB7A, RAB9A, FABP6, PLCD1, DUSP3, BCAP31, TPMT, IRAK1, PSMD7, STAT5B, NEK2, UBE2E1, PGD, KPNA2, KPNA1, RAP1GDS1, JAK3, MAP2K6, ARHGDIA, ARHGDIB, STAT2, KIF11, HRSP12, CAPZA1, PLK1, ARFIP1, MVD, COPA, AP2S1, POLR2K, PLA2G16, IST1, RARS, ATXN3, CACNB3, OAZ1, YARS, PRKAG1, PRKAA2, BCAT1, EPHB4, EPHB1, GYS2, EMP2, EIF5, CSE1L, VCP, CASP9, CASP6, SEC13, NPEPPS, SH3BGR, EIF3B, BID, AP1S2, HDAC4, EIF6, PEX3, MAP3K7CL, GEMIN4, PCBP4, NUP107, SNX16, SESN2, MTPN, TIRAP, NLRP5, ARPC4, SEC61G, TPI1, PTEN, GABARAPL2, MYL6, ACTB, RAC3, EIF4A1, RPS20, SNAP25, PRPS1, CDC42, SRP54, UBE2D3, UBE2M, ACTR3, ACTR2, RAP2B, RPS3A, RPL26, PSME3, RPL15, RPL27, RPL37A, RHOA, NCALD, SEC61A1, STXBP1, COPZ1, RPL37, AP1S1, NUTF2, RPS7, PPP1CA, PPP1CB, CALM2, NCS1, PSMC1, RPS8, RPS15A, RPS16, YWHAE, RPS14, RPS18, RPS13, RPS11, SNRPF, LSM3, LSM6, SNRPD1, SNRPD2, SNRPD3, PSMC6, RPL7A, RAB11A, PPP2CB, ACTA2, RHOB, RPL23A, RPS6, RAB1A, RAP1A, RPS25, RPS26, GNB1, POLR2L, RBX1, GNB2, RPL30, RPL31, RPL10A, RPL32, RPL11, PPIA, RPL41, RPS27A, UBA52, GRB2, RAC1, AP2B1, VAMP2, YWHAZ, DYNLL1, RPL38, SKP1, RPS21, EIF5A, RACK1, ACTG1, ACTG2, UBE2I, TPM4, ACTC1, EEF1A1, TUBA4A, TUBB4B, PAFAH1B2, HBB, HBG1, HBA1, IGBP1, PIP4K2B, CCT2, CCNA1, GSTO1, PRKDC, BLOC1S1, BTG2, CRADD, NUCB2, TMF1, RPL24, RPL36A, SMAD3, ARF1, RPL19, SERF2, GNAS, SHC2, XIAP, FOXO4, CYCS, TFAM, CDK6, CDK5, HSF1, SORD, MYBPC1, IRF9, MDM2, PLIN5, SPTBN1, SET, RELB, AMPD3, MYL7, FABP5, ANK2, HMGCS1, SLC7A5, POU5F1, OCRL, MYL5, CENPE, KIF23, ID2, APBA1, RPL18A, MAP2K1, FKBP4, DST, GSTM4, CENPC, MVK, RELA, GBE1, TLE1, PRKCQ, GLO1, AKR1C1, REL, YWHAH, ICA1, PTK2, LIPE, ZBTB16, PRKCD, CALD1, RNASEL, PTPN11, PPAT, GFPT1, EXOSC9, AOX1, SULT2A1, PRDX1, RPL18, C1QBP, TJP1, ZFP36L1, KHDRBS1, BAX, MCL1, SOS1, SOS2, PPP3CA, CRYZ, PDE4C, PDE4D, DMPK, NCBP1, KCNA1, AHNAK, HSPA14, AP1B1, NUP160, SREBF2, FOXO1, AKAP13, CDC20, STX4, DPYD, HYAL2, TRIM26, ANK3, DLG1, RALGDS, ABR, TIAM1, ARHGAP5, STK4, TRAF1, CHAF1B, MTAP, EIF2B5, FADD, PRDX4, MAP2K5, MAPK7, PAK2, CBLB, PSMD2, DNAJC3, SELENBP1, MAD2L1, G3BP1, SKP2, GRB10, ITGB3BP, PPP2R5C, PDE3B, PDCL, UBE2V1, DYNC1I2, ORC1, ILK, XRCC4, UNC119, GOLGA4, MYO9B, NFATC2, GAB1, SMAD4, BIRC3, MTM1, SQSTM1, EIF4EBP1, RIPK1, HDAC1, CAMK2D, DCTN2, NAE1, ITPK1, IQGAP2, SNX1, MTMR1, MTMR2, CUL2, CUL3, CUL4B, FHL1, PMAIP1, BLMH, EXOSC2, RAPGEF1, IDI1, PDE7A, CUX1, CKAP5, HNRNPD, IL18, DAG1, EIF3A, ARHGEF7, DPYSL3, DCTN1, DYNC1H1, EIF2B1, EIF4A2, TRIM25, FLNC, GALE, PDE3A, CAPRIN1, GRB14, SLBP, NBR1, RASA3, KCNJ11, PUM1, ESPL1, SMC1A, RRP1B, LPIN1, PPP2R5D, COG2, CASP8, KIF22, NFATC4, KPNB1, PSME4, CUL7, ARHGAP19, NCAPH, NCAPD2, EXOSC7, ARL6IP1, KARS, KIF14, EEA1, NCF4, PAFAH1B3, PEA15, PRKD1, PCM1, PPP2R5B, PTGES3, QPRT, RASA2, RNPS1, ERBB4, RALBP1, ANKRD1, RPS6KA2, TCEB1, TCEB2, RHEB, DHCR24, RPS6KA1, SEC23A, SHB, STIL, RGN, TESK1, DIXDC1, TRADD, TSN, TRIP10, MAPRE1, ELAVL1, MYLK, TAB1, SMAD2, SMAD1, ITSN1, STK11, STXBP2, VAMP3, NEDD8, HSPB2, SEPT7, UAP1, PKN1, PKN2, MAPK14, CDC37, DPYSL2, FXN, NTRK2, FSCN1, HIF1A, IFI16, KYNU, GUK1, HAGH, DUSP6, DUSP7, UPP1, UGP2, DGUOK, ATP6V1F, PFKFB3, PFKFB4, CDO1, TXNRD1, LONRF1, PDS5A, ARHGAP31, ERCC6L, TSR1, HKDC1, LRRFIP1, TKFC, CCDC88A, COX19, PREPL, AMOT, MIDN, ARHGAP29, PDCD4, C11orf73, KLHL12, PYCRL, CDCA8, SGOL2, PAN3, ODF2, PDZD11, CMPK2, SGOL1, HERC4, WDR44, DOCK11, CEP78, HABP4, GNAS, WIPI1, EXOSC6, LDLRAP1, THEM4, BCL2L15, HECTD2, ARHGEF16, DENND4C, LRRC16A, FBXO31, CEP135, WWC2, XAF1, NADSYN1, JADE1, DENND5A, JMJD6, PTRF, ARHGAP11A, PPIP5K1, PSRC1, BORA, SHQ1, PAPD4, CPLX2, BLOC1S3, RICTOR, SARM1, AFTPH, RANBP10, DSTYK, RNF19B, PHLPP2, SYDE1, VPS13C, USP34, CENPU, TUBA1A, RHOU, ASRGL1, CENPQ, CYFIP1, RASGRP2, MON2, RNF144B, NPHP3, HAUS6, ARHGAP22, WAPL, NET1, SPRED1, SRGAP1, RBBP6, ARHGAP30, FGD2, RABEPK, PNPLA5, HUWE1, SDCCAG8, TTC7B, NOXA1, NT5DC3, AACS, ALYREF, IQGAP3, TAX1BP1, HOOK3, OSTM1, PKHD1L1, NLRC5, TRIM69, CARM1, CEP57, GPSM1, MIB1, DCP2, MINA, SIAH1, TRAPPC5, TPH2, UBR1, BBS7, WWC1, TP53INP2, SIRT2, MSRB3, FAM126B, AMOTL1, SRRM1, TRIM22, XRN1, ABI1, CENPL, TAGAP, ADSSL1, AHI1, CA13, ARHGEF28, ARHGAP24, APITD1, ARHGAP18, SFRP1, MINK1, TAB3, ARFGAP2, ENAH, HSD17B11, SPC24, SMG8, TNRC6A, ABCF1, PIK3C3, TRPV1, ATP6V1C2, DOCK8, NUP43, NUP37, ENGASE, BBS1, NUDT10, CMAS, CASC5, CEP70, KIF18A, TTC8, OSR1, GSDMB, TBC1D16, NT5C, DYNC2LI1, RHPN1, NEK9, TRPM4, RB1CC1, GEMIN5, FBF1, RAPGEF6, PARD3, ABHD5, PDCD6IP, FBLIM1, CHAC2, DEPDC1B, PHLDA1, BLNK, SNX33, SKA2, DNAJA4, GLMP, CYGB, ARAP3, EDARADD, GEMIN6, MYLIP, AHCTF1, RSPH1, TTN, ARAP2, RFFL, RAPGEF4, STARD8, GBF1, ELMO1, NDRG1, HSPH1, DOCK2, TBC1D5, NSMAF, AKAP1, TFG, USP6NL, HTRA1, STAM, GOLGA1, GGH, INPP5D, BCL2L2, TANK, KIFAP3, UFD1L, BAD, KHSRP, ARHGEF2, CUL5, TNFRSF25, HGD, RFK, ITFG2, PPP1R14A, TP53INP1, RERG, EXOC4, PNPLA2, PBXIP1, MIB2, EXOSC8, SKA1, SGK3, UPRT, MOAP1, HAUS1, OPTN, AP2M1, TUBGCP3, ANAPC16, SPDL1, HOOK2, SEH1L, MOCOS, MVB12A, CYFIP2, EDC3, PELI1, CDCA5, S100A16, DPH3, BICD1, PGM2, NUDT11, AURKB, CENPN, PDLIM5, DOCK6, SCLY, AJUBA, ZBED3, ABHD14B, NSL1, ITCH, SEC16B, DNAJC1, EXOC2, MARK4, PRMT6, CARD19, FGD4, PACRG, AK8, AGBL1, KCTD7, PRICKLE1, ANKRD27, ARAP1, IPO9, INPP4A, NEDD4L, SYNGAP1, FMNL2, SMG1, ALS2, GSDMA, DLC1, RAB3IP, VPS35, MCCC1, TRIB3, TP53RK, RANBP9, CEP89, NMNAT3, FAM129B, SEC62, STAC, PLIN2, NUP88, PIK3R4, TSC22D3, S100A13, DNAJC7, CDCA3, PKMYT1, CHP1, KIF2C, MAP3K5, MGLL, DOK1, MTR, SMAD5, CDC6, NPAS2, EPAS1, CCT7, HAUS7, PRMT1, DUSP9, SH3GL2, CITED1, VRK1, NCAPG, MAPKAP1, FERMT1, CORO1B, AIFM2, CENPK, INPP5K, POLR3GL, DCTN5, CENPO, DOHH, MKNK1, POLR3C, PDCD10, BDH2, CHAC1, ADI1, RNF126, MLST8, TRIM62, PHF20, DUSP23, NUP85, CDK19, SORBS1, BBS2, NPL, PINK1, IDI2, PACSIN1, HDAC8, POLDIP3, DUSP16, PARD6B, TRIM34, WNK3, PANK2, NUF2, ASPSCR1, OSBPL6, DPH1, TRIM8, UCK2, TRIM6, STRADB, NDEL1, MAP1LC3B, EIF5A2, UBA5, PAIP1, TOLLIP, RACGAP1, WWP1, AP5M1, GABARAPL1, ATG10, RBM38, ANAPC1, POLR3F, UPF3A, CDT1, SPTBN4, ALDH8A1, TNKS2, DPH5, DHX36, TXNIP, MUC13, CENPH, TPK1, DSN1, CHMP4B, MAP1LC3A, WNK1, RHOJ, EPB41L1, RGCC, GSTO2, HAUS4, EGLN3, DCTPP1, SYNC, PLEKHG2, PHAX, MOB1A, AKTIP, ECT2, ZWILCH, PSTPIP2, SEC61A2, LIN28A, UCK1, PELI2, PLEKHA5, SMURF2, UPF2, SCPEP1, RRAGC, AS3MT, SPC25, ETNK1, APOBEC3G, CENPJ, CAPN10, NEK6, MCCC2, TNRC6C, AGO4, TRIM39, SEPSECS, MYO10, PDE7B, ARFGAP3, VTA1, MID1IP1, PARD6A, EXOSC4, ISYNA1, MKKS, ACOT13, PLCB1, CYLD, RRAGD, PFDN4, EXOSC3, KIF13B, ACSS2, EIF2B3, ARHGEF4, ARHGEF3, PDGFC, EIF4ENIF1, SH2B1, CTPS2, PRTFDC1, LATS2, AASDHPPT, UBQLN4, INPP5E, SNX15, RAB6B, PHPT1, KIF15, HOMER3, SAMSN1, CENPM, DIAPH3, NRBP2, PDS5B, SMC4, ECHDC1, RNF146, ABHD10, TXLNG, NUDT15, RNF19A, EXOC1, PARVA, FGFR1OP2, RLIM, HAUS2, POLR3B, RNF216, UCKL1, GEMIN8, DDIT4, MKS1, PGPEP1, NDE1, SPHK1, MTMR4, ABI2, DACT1, FAM13B, BET1L, PLK2, GTSE1, ERAP1, FMN2, GLTP, IL37, RGL1, MAT2B, EHD3, AKAP7, ARHGAP23, ARHGAP20, CC2D2A, TBC1D14, ANKFY1, ATXN10, NFKBIL1, SAE1, NLK, PI4KB, HDAC6, VPS29, EIF3K, GRHPR, CTNNAL1, NXF1, ZMYM2, TJP2, DNAJB4, VTI1B, ADD3, PRKAG3, SEC63, KLHL3, TBK1, DDX20, BAIAP2L1, EVL, EIF2B4, ATP6V1H, LCMT1, SCOC, LNPEP, CNOT7, ERRFI1, CDC23, ANAPC5, ANAPC4, LSM7, CDC42EP3, NXT1, NUDT5, PCTP, FBXO5, AGO2, VAV3, MYH2, BAG5, BLOC1S6, MKLN1, WWC3, KIDINS220, ASAP1, CNOT6, NDRG4, TPX2, NOB1, PYCARD, PADI4, FZR1, ANAPC10, MYO6, NFU1, SUFU, NDRG2, G3BP2, ARHGAP26, STUB1, SNX6, ANGEL1, FAF1, NSFL1C, PLA2G4C, B9D1, PPP6R1, TNRC6B, SMG5, EXOC7, AGTPBP1, DICER1, SMC3, MAPK8IP1, SH2B3, GNE, POMP, CHKB, FARSA, BTRC, BTBD3, NISCH, PIKFYVE, DIS3, HIF3A, POLR1D, CRYL1, CARHSP1, GIT1, POLR3K, SUGT1, DERA, LSM2, CAB39, TPRKB, HDGFRP3, STARD13, RABGAP1, RPL36, C2CD2, WDR45, TLN1, KIF3A, DAAM1, FARP1, IRS2, MYO5A, WIPI2, ARIH1, LSM5, LSM4, RNF114, CEP83, YTHDF2, PAXBP1, UCHL5, ATP6V1D, N6AMT1, TRAPPC1, RBM8A, SNX5, PSAT1, COPG1, SAR1B, ARFGEF2, MAD1L1, STK24, SNCAIP, IGF2BP2, SESN1, WASF2 |
GO:0005832 | CC | chaperonin-containing T-complex | A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor. |
TCP1, CCT6A, CCT3, CCT8, CCT2, CCT7 |
GO:0005833 | CC | hemoglobin complex | An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. |
CYB5R3, HBB, HBG1, HBA1 |
GO:0005834 | CC | heterotrimeric G-protein complex | Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. |
GNG7, GNAI2, GNAI3, RGS7, GNG4, GNG11, GNB1, GNAI1, GNG5, GNA12 |
GO:0005838 | CC | proteasome regulatory particle | A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex. |
PSMD12, PSMD10, PSMD7, PSMD2 |
GO:0005839 | CC | proteasome core complex | A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. |
PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMB10, PSMB3 |
GO:0005840 | CC | ribosome | An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. |
PRMT3, EIF2S1, RPS17, MT3, CANX, SNCA, RPS27, RPS9, RPS10, RPL15, RPL27, RPS7, RPS18, RPS13, RPS11, RPS25, UBA52, MRPS25, MRPS10, MRPS34, RPL36A, HSPA14, DNAJC21, MRPL54, MRPL14, MRPL50, ABCF1, GCN1, MRPL38, METTL17, MRPL44, RRBP1 |
GO:0005844 | CC | polysome | A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. |
EIF2S1, RPS4Y1, EIF4B, PSMA1, CALR, FUS, FXR1, RPS6, FMR1, NAA30, GCN1, MSI2, UNK, EIF2AK4, IMPACT, AGO2, DRG1 |
GO:0005845 | CC | mRNA cap binding complex | Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. |
EIF4E2, EIF4E, FMR1, NCBP1, CYFIP1, AGO2 |
GO:0005846 | CC | nuclear cap binding complex | A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. |
NCBP1 |
GO:0005847 | CC | mRNA cleavage and polyadenylation specificity factor complex | A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. |
CSNK1A1, CPSF1, FIP1L1, ZC3H3, SSU72, CPSF2 |
GO:0005849 | CC | mRNA cleavage factor complex | Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. |
NUDT21 |
GO:0005850 | CC | eukaryotic translation initiation factor 2 complex | Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. |
EIF2S1 |
GO:0005851 | CC | eukaryotic translation initiation factor 2B complex | A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. |
EIF2S1, EIF2B5, EIF2B1, EIF2B3, EIF2B4 |
GO:0005852 | CC | eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
DDX3X, EIF3J, EIF3B, ABCE1, EIF3A, EIF3K |
GO:0005853 | CC | eukaryotic translation elongation factor 1 complex | A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. |
EEF1B2, EEF1D, EEF1A1, EEF1A2 |
GO:0005856 | CC | cytoskeleton | Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
FRMD3, PDLIM1, HIP1, SDCBP, TOR1A, ENC1, ITGB1BP1, RAB29, SYNJ2, NPHP1, TGFB1I1, RIPK2, SPRY2, PDE6D, LZTS3, PPL, MPZL2, SORBS3, JAK2, LDB3, HSBP1, ARL6IP5, FARP2, PNP, KRT1, HSPB1, S100A8, S100A9, TPM3, TUBB, PFN1, VIM, KRT16, TPM1, FGR, ALDOC, DMD, JUP, KITLG, JAK1, STOM, MAPK3, MAPK1, PTPN4, NOS3, NF2, ACTN2, LRPPRC, CAPZB, CCT3, HINT1, CNN1, JAK3, MAP2K6, ARHGDIA, ARHGDIB, CAPZA1, SMTN, GYS2, EPPK1, ACTB, RHOA, ACTG1, TPM4, TUBB4B, CDK5, ANK2, PTK2, CALD1, NEXN, MYO1E, CALCOCO2, SNTA1, SHROOM2, SNTB1, COTL1, DAG1, CTTN, FLNC, CASP8, FRMPD4, DHCR24, TRADD, TRIP10, TRIP11, TRIP6, CCDC6, SGCB, FSCN1, PTPN21, LRRFIP1, PREPL, WIPI1, TBCEL, FNBP1L, ARHGAP21, KAZN, TWF2, SLC30A9, DNMBP, FGD6, RAPH1, SSH2, MAEA, FGD2, NEK8, NOSTRIN, ABI1, ARHGAP24, ENAH, JMY, BICD2, SSH3, RNF128, PARD3, SHROOM3, ARAP3, TRIB2, DOCK2, SGCD, SYMPK, INPP5D, ARHGEF2, BICD1, TCTN2, SGCZ, FRMD6, KLHL5, RAB3IP, FNBP1, PKP4, DNAJC7, MARVELD1, OSBPL10, PINK1, UACA, TRIM9, KLHL4, ACTR6, EPB41L4B, DEF6, EPB41L1, PSTPIP2, TNS1, EPB41L4A, SPAG4, CASS4, GPHN, CDC42SE2, CDC42SE1, PARVA, ABI2, DNAH9, PLEK2, MARK1, CC2D2A, FRMD4A, UXT, CTNNAL1, ADD3, KLHL3, DDX20, EVL, DNAI1, TNIK, TAOK2, PLEKHH1, ARHGAP26, MACF1, SLC7A11, EPB41L3, FRMD4B, FARP1, FAM65B, CDC42BPB, IGF2BP2, PCLO |
GO:0005858 | CC | axonemal dynein complex | A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. |
DNALI1, DYNC2LI1, DNAH1 |
GO:0005859 | CC | muscle myosin complex | A filament of myosin found in a muscle cell of any type. |
MYL6B, MYL9, MYH11, MYL5, TTN, MYH2, MYH4 |
GO:0005861 | CC | troponin complex | A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction. |
TNNT1, TNNI3 |
GO:0005862 | CC | muscle thin filament tropomyosin | A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments. |
TPM3, TPM2, TPM1, TPM4 |
GO:0005865 | CC | striated muscle thin filament | Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils. |
TMOD1, LMOD1 |
GO:0005868 | CC | cytoplasmic dynein complex | Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. |
DYNC1I1, DYNC1LI2, BCL2L11, SNX4, TPR, DYNLL1, DYNLT1, DYNC1I2, DYNC1H1 |
GO:0005869 | CC | dynactin complex | A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach. |
DCTN6, ACTR1B, DCTN2, DCTN1 |
GO:0005871 | CC | kinesin complex | Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. |
KIF1C, KIF5C, KIF1B, KIF20A, KIF4A, KIF11, YWHAE, CENPE, KIF23, KIF22, KIF14, KLC3, KIF18B, KIF18A, KIF20B, KIF2C, KIFC1, NDEL1, KIF13B, NDE1, STARD9 |
GO:0005873 | CC | plus-end kinesin complex | Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule. |
LOH12CR1, KIF15 |
GO:0005874 | CC | microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
EML1, KRIT1, DYNC1I1, MID1, BIRC5, DYNC1LI2, SYNJ1, SPRY2, ZNF207, KIF1C, KIF5C, KIF1B, TPPP, HAUS5, WDR47, KIF20A, PCNT, EML2, TTLL1, DNAL4, TUBB4A, TUBB, MAPT, MAP2, STMN1, TCP1, MT3, CLIP1, MAP2K2, CCT6A, LRPPRC, MAP1B, IQGAP1, CCT3, EMD, CCT8, NEK2, KIF11, DYNLL1, TUBA1B, TUBA4A, TUBB4B, IGBP1, CCT2, MAP1A, CENPE, KIF23, FKBP4, GOLGA2, CAMSAP2, DNAH14, DLG1, TIAM1, MTA1, DYNC1I2, SNTB2, TUBB3, DCTN2, TUBA3C, SHROOM2, TUBB2A, EIF3A, DCTN1, DYNC1H1, MAP7, KIF22, KIF14, MAPRE1, DPYSL2, CSPP1, FAM110C, TTLL9, ODF2, CEP170, CAMSAP1, REEP3, KLC3, SARM1, DNAH12, TUBA1A, HAUS6, HOOK3, RASSF3, GAS2L3, CEP57, LRRC49, DNAH10, CCDC50, SIRT2, NAV1, MDM1, NEK7, DNAH5, SHROOM3, RASSF5, NDRG1, HSPH1, APPBP2, FGF13, ARHGEF2, TEKT1, PBXIP1, HAUS1, RMDN1, DNAH11, HOOK2, RMDN2, KIF20B, FEZ1, CCT7, HAUS7, TBCD, TUBB6, KATNB1, TUBB2B, KIFC1, KATNAL1, NDEL1, MAP1LC3B, RACGAP1, GABARAPL1, MAP1LC3A, TUBB1, HAUS4, EML4, CENPJ, NEK6, MID1IP1, KIF13B, RASSF1, KIF15, TCP11L1, STAU2, SYBU, NDE1, DNAH9, CAMSAP3, DNAH1, HDAC6, SPAST, DNAI1, TEKT2, TUBE1, TUBD1, MTUS1, TPX2, MACF1, INVS, FAM179B |
GO:0005875 | CC | microtubule associated complex | Any multimeric complex connected to a microtubule. |
EML1, MID1, KIF1B, STAU1, EML2, MAPT, MAP2, MAP1B, RANBP2, MAP1A, MAP7, PEA15, APPBP2, RANBP9, DNAAF2, HDAC6, CLIP2, RABGAP1 |
GO:0005876 | CC | spindle microtubule | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. |
AURKA, HDAC3, PRC1, TBL1X, NCOR1, KIF4A, CDK1, CDC27, CSNK1D, KIF11, PLK1, CALM2, PSRC1, SKA3, SKA2, KIFAP3, SKA1, AURKB, SPAG5, NUSAP1, TBL1XR1, HAUS2, KIF3A |
GO:0005879 | CC | axonemal microtubule | A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. |
ARFGEF2 |
GO:0005881 | CC | cytoplasmic microtubule | Any microtubule in the cytoplasm of a cell. |
AXIN1, MID1, BCL10, SAA1, CYP2A6, TUBG1, APC, CLIP1, DYNLT1, TUBA1B, MAPRE1, TUBA1A, DCXR, HID1, DYNC2LI1, CKAP2, BICD1, GRAMD3, KIF2C, VIMP, ENKD1, TRPV4, CYLD, GTSE1, HDAC6, CLIP2, SRPRB |
GO:0005882 | CC | intermediate filament | A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. |
KRT18, KRT8, VIM, KRT19, KRT7, KRT16, KRT3, JUP, NME1, DSP, GJA1, DES, NME2, CLIP1, KRT9, SLC1A4, NES, DST, KRT17, IFFO1, MNS1, MICAL1, PKP2, KRT23, PNN, SYNC, MYO5A |
GO:0005883 | CC | neurofilament | A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter. |
NRP1, NEFH, LDLRAP1 |