GO:0001673

CC

male germ cell nucleus

The nucleus of a male germ cell, a reproductive cell in males.

H2AFX, MLH1, TRIP13, TOPBP1, MLH3, TCFL5

GO:0001725

CC

stress fiber

A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

ABLIM1, ACTN4, FLNB, NEBL, ABLIM3, TPM3, TPM1, ACTN1, LCP1, MYL9, MYH9, TPM4, TEK, PTK2, ILK, MYLK, ZYX, SEPT7, FSCN1, FBLIM1, PDLIM2, CORO1B, SORBS1, NOX4, PDLIM7, LIMA1, DAAM1, FHOD1

GO:0001726

CC

ruffle

Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

ITGB1BP1, MTSS1, CYTH3, COBL, S100B, ITGB1, S100A6, ANXA2, ITGA5, ACTN1, LCP1, EZR, RAB5A, RASA1, ATP6V1B2, NME2, CLIP1, S100A11, RDX, MYH9, IQGAP1, CDK6, MTM1, ARHGEF7, CTTN, FSCN1, AMOT, FGD6, CYFIP1, FGD2, PDPN, KIF18A, ARAP3, PALLD, ARHGEF26, FGD4, ALS2, TRPM7, MYADM, INPP5K, MYO10, TNFRSF12A, PARD6A, PDLIM7, INPP5E, SAMSN1, RAB22A, MKLN1, MYO6, FRMD4B, TLN1, MYO5A, SNX9, SNX5, WASF2

GO:0001739

CC

sex chromatin

Chromatin that is part of a sex chromosome.

H2AFY, RING1, SUZ12

GO:0001740

CC

Barr body

A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.

SMCHD1, H2AFY, H3F3A, H2AFY2

GO:0001741

CC

XY body

A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.

PLK4, SIN3B, H2AFX, UBE2A, UBE2B, ESCO2, SMARCC1

GO:0001750

CC

photoreceptor outer segment

The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.

OPN1SW, INHA, MAK, PDC, PTGS1, GNA11, MAP1B, GNAQ, RAB27A, OCRL, MERTK, PTPRK, BBS7, MYRIP, RPGR, MYO5A

GO:0001772

CC

immunological synapse

An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.

SOCS6, STX7, BCL10, ICAM1, PRKAR1A, CD28, EZR, LGALS3, CD53, CD6, CORO1A, MYH9, DUSP3, CD81, PRKCQ, PTPRJ, DLG1, ALCAM, PDCD6IP

GO:0001891

CC

phagocytic cup

An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.

MYO1G, PIP5K1C, TNF, ANXA1, LCP1, CORO1A, RAC1, RACK1, TRIP10, PEAR1, MEGF10, SYT11, CDC42SE2, BIN2, SNX5

GO:0001917

CC

photoreceptor inner segment

The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.

INHA, ENO2, MAK, PDC, GNB1, CROCC, DRAM2, PHLPP2, RDH11, GUCA1B

GO:0001931

CC

uropod

A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.

PIP5K1B, PIP5K1C, FLOT1, EZR, MYH9, SELPLG

GO:0001939

CC

female pronucleus

The pronucleus originating from the ovum that is being fertilized.

SLC2A1, CCNA2, CBX1, RIF1

GO:0001940

CC

male pronucleus

The pronucleus originating from the spermatozoa that was involved in fertilization.

CCNA2, CBX1, RIF1

GO:0002079

CC

inner acrosomal membrane

The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.

CD46, TRIP11

GO:0002080

CC

acrosomal membrane

The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.

SERPINA5, BSG, CAV2, CAV1, PLA1A

GO:0002081

CC

outer acrosomal membrane

The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.

ZP3, TRIP11

GO:0002102

CC

podosome

An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.

SH3PXD2B, LPXN, WDR1, LCP1, VCAM1, TPM4, ADAM8, ARHGEF5, CTTN, FSCN1, RHOU, PALLD, BIN2

GO:0002116

CC

semaphorin receptor complex

A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

NRP1, PLXNB2, NRP2, PLXNC1, PLXNA2, PLXNA3, PLXNA1, PLXND1

GO:0002133

CC

polycystin complex

A stable heterodimeric complex composed of polycystin-1 and polycystin-2.

PKD1, PKD2

GO:0002169

CC

3-methylcrotonyl-CoA carboxylase complex, mitochondrial

A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.

MCCC1, MCCC2

GO:0002177

CC

manchette

A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.

IQCG

GO:0002178

CC

palmitoyltransferase complex

A protein complex with palmitoyltransferase activity.

ZDHHC9

GO:0002189

CC

ribose phosphate diphosphokinase complex

A protein complex having ribose phosphate diphosphokinase activity.

PRPS1

GO:0002193

CC

MAML1-RBP-Jkappa- ICN1 complex

A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.

NOTCH1

GO:0002199

CC

zona pellucida receptor complex

A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.

TCP1, CCT3, CCT8, CCT2, CCT7

GO:0002944

CC

cyclin K-CDK12 complex

A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.

CDK12

GO:0002945

CC

cyclin K-CDK13 complex

A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.

CDK13

GO:0002947

CC

tumor necrosis factor receptor superfamily complex

A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.

RFFL

GO:0005575

CC

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

TMEM129, TMEM120B, SBNO1, NUDT19, TRIM38, DLGAP1, KHNYN, SOX12, DENR, TRAF3IP2, ZNF862, EIF1B, USP12, PDE5A, ZFAND5, PDE8B, GDF11, DHFR, SCT, ZNF688, PSKH1, ODC1, TPR, CCDC130, S100A2, NPTX2, SLC6A8, PLA2G16, SHC2, RNASEL, DMWD, MN1, TFCP2, TRIM26, NPRL3, SCGB2A2, MAMLD1, FAM53B, NOMO1, FAM189A2, QRICH1, LRRFIP1, ARID4B, LRRC23, TMEM35, ACSM3, ANKRD39, BOLA3, TMEM128, RALGPS1, MLK4, ANKRD45, SPTY2D1, ANKRD40, ZFAND6, ADNP2, TTC27, RNASEK, TMEM107, TMEM108, ADAMTSL4, TMEM91, LHFPL2, PTCHD4, USP53, SLC35D2, KNDC1, ENOSF1, KDELC2, GALNT5, THNSL2, CARKD, SLC35F2, THNSL1, GCNT2, TMEM132C, OXR1, ABTB2, SLC43A3, SMG8, PAPD5, ABHD11, WDR36, AGR3, DNAH5, SCFD2, CHAC2, SNRNP27, RIN2, SUSD6, KIAA1191, FLYWCH2, MOCOS, DTD2, PBK, ZFP3, PCYT2, CDCA3, TMEM121, HGH1, DOHH, C9orf16, TMEM106C, TMEM120A, FSD1L, RTFDC1, ASPSCR1, UCK2, ZC3H12C, C20orf27, SPATC1L, XYLT2, HSD3B7, DPH5, PLEKHA4, FAM96A, MRPL44, C17orf75, EPB41L4A, MRPL47, SMCO4, HOMER3, TMEM51, VNN3, DONSON, NKIRAS1, RGL1, SIPA1L2, PSMC3IP, IMPACT, STOML1, ARPP21, CFDP1, EPHA6, MKRN1, CHORDC1, OSGIN1, GPATCH8, ARHGAP26, EXOG, DIP2C, GPSM3, AIM1, AMMECR1, RAI2, LRRFIP2

GO:0005576

CC

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

VWA8, IGIP, MASP2, TNFRSF11B, RNASET2, ISLR, NCAN, PRRG1, TNFSF11, EREG, PDZD2, SEMA3E, NPC1, ANGPT2, ADAM12, KLK10, SPINT2, ACTN4, CALU, CD5L, NRP2, FCMR, ADAM23, WDR1, TULP3, CA11, LRP6, TNFSF13, FGF18, SLIT2, DKK1, NXPH3, CSPG5, BMP10, FGF19, IL33, EFEMP2, F8, F13A1, F2, C1R, HP, PLG, PLAU, PLAT, CFB, SERPINC1, SERPINA1, SERPINA3, AGT, A2M, C3, TIMP1, CST3, KNG1, PDGFB, TGFB1, NGF, GNRH1, POMC, PENK, CGA, FSHB, LHB, PRL, GH1, PTH, GCG, GHRH, INS, IGF2, TNF, IFNA1 , IL1A, IL1B, COL1A1, COL3A1, APOA1, APOE, APOA2, APOC3, FGA, FGB, FGG, CRP, APCS, C1QA, APOH, LRG1, FN1, RBP4, AMBP, ORM1, AHSG, TTR, ALB, GC, PPBP, PF4, TFRC, TF, ANG, MMP1, AMH, VTN, ALDOA, ANXA1, PDGFA, APOB, A1BG, S100B, VWF, SHBG, PRB1, IFNA16, IGF1, CHGB, APP, APOD, S100A8, INHA, SERPINE1, SERPINA5, SERPING1, CFI, F13B, ISG15, IL6, EDN1, SCG5, CLEC3B, COL5A2, CCK, S100A9, LPL, SERPINE2, P4HB, KLK3, CTSD, C8G, TUBB, PRSS1, DCN, PSAP, CTSL, CTSB, HSP90AA1, LAMB1, THBS1, COL1A2, NGFR, CD55, CELA2B, MMP2, SOD3, INHBA, CD14, COL4A2, MET, CFH, IGFBP1, IL6R, NMB, FGF2, MMP10, CXCL1, HMGB1, PAEP, SPARC, INHBB, WNT2, SCT, C1S, C4A, C4B, SAA1, CGB5, CGB7, SRGN, CXCL8, CCL3, RNASE2, SPP1, C7, TFPI, CLU, GHR, HAPLN1, IAPP, LAMC1, MBL2, FGFR1, SFTPC, COL11A1, COL6A1, COL6A2, COL6A3, F5, PTHLH, BMP2, BMP4, ACTN1, ACE, DEFA4, CCL4, BMP1, CCL2, CCL5, VCAN, C6, PRG2, COL11A2, MIF, HGF, NID1, PLA2G2A, HSP90B1, IL1R1, MMP9, LIF, VEGFA, TIMP2, PRLR, NPPB, IL7R, IGFBP3, IGFBP2, EPOR, ORM2, CXCL2, FST, KLK2, TNFRSF1B, TRH, OGN, EDN2, IL11, EFNA1, COL9A1, COL5A1, FLNA, KITLG, MDK, ZP3, FGF7, BGN, GPX3, GAL, IGFBP4, MMP8, FBLN1, ANOS1, CBLN1, BDNF, LAMA2, MMP11, IGFBP6, IGFBP5, TNC, COL8A2, F2R, AZGP1, CTSS, COL5A3, PTX3, CD27, MST1, PON1, CALR, CFP, IL1R2, AOAH, LOX, CTGF, EPHA3, EPHB2, IL12A, CASP1, CD6, LRPAP1, NTS, S100A7, FGF9, GBP1, RNASE4, PRSS3, BTC, ADM, THBS4, FBN1, FBN2, ACTN2, TIMP3, FLT4, MAP2K2, SERPINF1, SNCA, COL15A1, COL18A1, PLA2G5, IL6ST, ADH7, PMEL, LEP, WNT5A, PTGDS, CXCL5, GDF5, PTGFR, CTSK, NOTCH1, NPTX2, GLIPR1, CXCL12, LEPR, IFNAR2, NMU, CASP4, COMP, PGF, VEGFB, VEGFC, SEPP1, AGTR2, TNFSF10, PPT1, INSL3, LUM, EFNA4, EFNA5, CAPZA1, CRISP3, EPHB4, EPHB1, MFAP2, MFAP3, INHBC, GFER, WNT3, ANTXR2, NXPH1, PTEN, ZP1, LYZ, B2M, TGFB2, CALM2, TMSB4X, HIST1H4A, PPIA, TUBA4A, HIST1H3D, HBB, HBA1, CXADR, JAG1, CCL20, CXCL6, LCN2, HAMP, CRB1, HTRA3, H3F3A, FBLN2, HSPG2, IL9R, COL4A3, NRG1, MUC3A, TEK, COL10A1, NOTCH2, CD164, COL14A1, FMOD, COL16A1, LOXL1, MFGE8, GALNT1, ST3GAL3, EFEMP1, FSTL1, PSG7, PLA2G7, SPP2, MMRN1, PAPPA, CHIT1, MFAP5, COL4A6, NID2, IL18, DAG1, GAS6, SEMA3A, LTBP1, KARS, NECTIN1, ERBB4, ANGPT1, FCN2, RGN, TGFBI, KISS1, CLUL1, ADIPOQ, IGFBP7, LAMA4, PSG3, CTF1, LAMA3, ST3GAL2, MST1L, MMEL1, BOLA3, PDZD11, HABP4, COL13A1, ABHD17B, SUSD4, OLFML2B, C12orf73, CTRB2, LAIR2, APOA5, CSPG4, ENHO, ARSK, DHRS13, FAM150B, FAM131A, PAMR1, IL34, NOTCH2NL, FAM19A5, LYG2, C6orf1, ITIH5, VASH2, CD163, CHSY1, WFDC3, VSTM4, GLB1L2, CNTN4, SCUBE3, LAS2, LYPD1, AGGF1, MUC20, MUC15, PRSS35, SFRP1, C2orf69, HSD17B11, NPB, LILRB1, FIBIN, SPATA20, NDNF, BPIFB1, DEFB104A, CYB5D2, CEMIP, C1orf54, TTN, FAM3C, HSPH1, ESR2, HTRA1, TNR, NRCAM, FGF13, FGF11, FGF14, PRG4, TNFRSF25, WNT2B, MR1, VWCE, MUCL1, RSPRY1, BCAN, APOLD1, GLT1D1, VSTM2L, COL21A1, HHIP, GPX7, CSF3R, HBEGF, NELL2, PLIN2, MMP19, COL12A1, PROL1, EGFL8, RARRES2, OMD, GDF15, SOST, APOL2, CCDC3, PRADC1, NDFIP1, MENT, APOO, C1QTNF7, EMILIN2, RSPO3, UACA, PLA2G12A, SIGLEC1, TINAGL1, PDGFD, WNT5B, CXCL16, GREM2, TREM1, NGRN, IL1RAP, ESM1, CD163L1, PDGFC, IL17RB, LTBP3, ERAP1, IL37, DSPP, CLCF1, CKLF, GABBR1, GHRL, KL, FAM198A, DMBT1, FETUB, TMEFF2, LNPEP, ENPP5, HEG1, APLN, PYCARD, COL17A1, PCDHA6, ADAMTS5, PROCR, TNFSF13B, ITM2B, BOLA1, C2CD2, TLN1, HYOU1, PCDHA10, PCDHA1, WIF1, LIPG, WNT6, LAMC3

GO:0005577

CC

fibrinogen complex

A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.

FGA, FGB, FGG, FN1, THBS1, FBLN1, FGL2

GO:0005578

CC

proteinaceous extracellular matrix

A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.

TNFRSF11B, MATN2, CHL1, CYR61, NCAN, FLRT2, COCH, CILP, TECTA, GPC4, CRTAP, WISP2, ECM2, SLIT2, WISP1, PAPLN, SERPINA1, TIMP1, TGFB1, MMP1, VWF, ALPL, MMP2, MGP, MMP10, LGALS1, WNT2, HAPLN1, COL6A2, COL6A3, BMP4, BMP1, VCAN, MMP9, VEGFA, TIMP2, OGN, COL9A1, ZP3, BGN, TNXB, MMP8, FBLN1, ANOS1, MMP11, COL8A2, CALR, LOX, CTGF, GPC1, FBN1, TIMP3, CHI3L1, WNT5A, TFPI2, COMP, MMP16, LUM, CRISP3, WNT3, ADAMTS12, ADAMTS20, ZP1, GPLD1, FBLN2, IL1RL1, TGFBR3, COL10A1, COL14A1, FMOD, COL16A1, EFEMP1, DGCR6, SPARCL1, LTBP1, POSTN, TGFBI, HSD17B12, CPZ, OLFML2A, CCBE1, GLDN, FBN3, PODN, SBSPON, GPC2, SFRP1, NDNF, ADAMTS17, ADAMTS15, ADAMTS18, SPOCK2, TNR, GLG1, WNT2B, CTHRC1, BCAN, COL21A1, MUC4, MMP19, EPYC, OMD, SPOCK3, SOST, SPON2, EMILIN2, CRISPLD2, WNT5B, SPON1, CD248, MMP25, CRTAC1, MMP26, FLRT3, FLRT1, DSPP, ADAMTS9, ADAMTS7, ADAMTS6, ADAMTS5, ADAMTS8, HPSE, MMP24, GPC6, WNT6, LAMC3

GO:0005579

CC

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

C8G, C7, C6

GO:0005581

CC

collagen trimer

A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.

C1QA, MBL2, COL6A2, COL8A2, LOX, COL18A1, COL10A1, COL14A1, FCN2, ADIPOQ, COLEC12, CCBE1, GLDN, COL23A1, CTHRC1, COL21A1, C1QTNF1, C1QTNF7, C1QTNF3, EMILIN2, COL17A1, COLQ

GO:0005582

CC

collagen type XV trimer

A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils.

COL15A1

GO:0005583

CC

fibrillar collagen trimer

Any triple helical collagen trimer that forms fibrils.

TNXB, LUM

GO:0005584

CC

collagen type I trimer

A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils.

COL1A1, COL1A2

GO:0005586

CC

collagen type III trimer

A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils.

COL3A1

GO:0005587

CC

collagen type IV trimer

A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.

COL4A2, COL4A3, COL4A6

GO:0005588

CC

collagen type V trimer

A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils.

COL5A2, COL5A1, COL5A3

GO:0005589

CC

collagen type VI trimer

A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils.

DCN, COL6A1, COL6A3

GO:0005592

CC

collagen type XI trimer

A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils.

COL11A1, COL11A2

GO:0005594

CC

collagen type IX trimer

A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils.

COL9A1

GO:0005595

CC

collagen type XII trimer

A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures.

COL12A1

GO:0005596

CC

collagen type XIV trimer

A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures.

COL14A1

GO:0005597

CC

collagen type XVI trimer

A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils.

COL16A1

GO:0005600

CC

collagen type XIII trimer

A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane.

COL13A1

GO:0005602

CC

complement component C1 complex

A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains.

C1QA

GO:0005604

CC

basement membrane

A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.

MATN2, CASK, EFEMP2, TIMP1, CST3, VTN, ANXA2, LAMB1, SPARC, LAMC1, NID1, COL5A1, FBLN1, ITGA6, LAMA2, TNC, COL8A2, FGF9, THBS4, FBN1, TIMP3, SERPINF1, COL18A1, CD151, EFNA5, HSPG2, COL4A3, DST, LOXL1, NID2, DAG1, TGFBI, LAMA4, LAMA3, CCDC80, P3H2, SMOC2, NTN4, ADAMTS1, COL17A1, SMC3, LOXL2, LAMC3

GO:0005605

CC

basal lamina

A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix.

FN1, ANG, NID1, LAMA2, DLG1, LAMA4, COLQ

GO:0005606

CC

laminin-1 complex

A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.

LAMB1, LAMC1

GO:0005607

CC

laminin-2 complex

A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains.

LAMB1

GO:0005610

CC

laminin-5 complex

A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains.

LAMA3

GO:0005614

CC

interstitial matrix

A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens.

ECM2, TNC, ADAMTSL4, CCDC80, NAV2, KAZALD1, SMOC2

GO:0005615

CC

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

SSPO, CNOT1, LGALS8, AGRP, CLIC1, TNFRSF11B, KRIT1, SDCBP, RNASET2, MAN2B1, CHEK1, NRP1, TNFSF11, MSTN, EREG, SEMA3E, ANGPT2, FLRT2, DHH, ACTN4, CD5L, ZFC3H1, GDF9, GREM1, SRPX2, HIST1H2BK, RAMP1, CILP, ENTPD6, GPC4, CREG1, SCRG1, CRTAP, TNFSF13, LYZL6, STC2, WISP2, FGF18, ECM2, SLIT2, DKK1, SEMA3D, WISP1, GDF11, BMP10, CXCL14, IL33, ANGPTL1, SCGB1D2, BMP15, F8, EGFR, F2, HP, PLG, PLAU, PLAT, CFB, ADA, CA2, SPINK1, SERPINC1, SERPINA1, SERPINA3, AGT, C3, TIMP1, CST3, CSTA, KNG1, PDGFB, TGFA, TGFB1, GNRH1, POMC, GH1, PTH, GCG, GHRH, INS, IGF2, TNF, IFNA1 , IL1A, IL1B, COL1A1, COL3A1, APOA1, APOE, APOC3, FGA, FGB, FGG, CRP, APCS, APOH, LRG1, FN1, RBP4, AMBP, ORM1, AHSG, TTR, ALB, GC, PPBP, PF4, TFRC, TF, BGLAP, ANG, AMH, SLPI, VTN, ALDOA, CSTB, ANXA1, PDGFA, APOB, A1BG, KRT1, S100B, HSPB1, IFNA16, IGF1, APP, APOD, S100A8, SERPINE1, SERPINA5, SERPING1, CFI, MPO, ALPL, IL6, EDN1, ICAM1, FABP3, CLEC3B, CCK, S100A9, ENO1, GPI, LPL, SERPINE2, KLK3, CTSD, ANXA2, DCN, PSAP, CTSL, CTSB, LAMB1, THBS1, COL1A2, CELA2A, CELA2B, MMP2, SOD3, CD14, MFI2, CFH, IGFBP1, FGF2, ENO2, GSTP1, CST2, MMP10, CXCL1, LGALS1, HMGB1, SPARC, INHBB, CNP, WNT2, HMOX1, CTSH, SCT, ALOX5, C4A, C4B, UBC, SAA1, SAA2, SRGN, CXCL8, CCL3, SPP1, TFPI, KIT, HSPD1, CLU, GHR, IAPP, LAMC1, ITGAM, MBL2, SFTPC, IGF2R, COL6A2, COL6A3, F5, PTHLH, CKB, BMP2, BMP4, BMP3, ACTN1, ACE, DEFA4, CCL4, TDGF1, LAMP2, BMP1, CCL2, CCL5, SCG2, VCAN, TPT1, ALAD, LCP1, ENO3, MTHFD2, MIF, HGF, CPM, PLA2G2A, IDE, MMP9, LIF, AKR1B1, PVR, CPN1, B4GALT1, ACPP, EZR, AREG, VEGFA, MUC1, TIMP2, PECAM1, SELE, CD36, NPPB, CPE, LGALS3, IGFBP3, IGFBP2, IL1RN, PAM, VCAM1, ORM2, CXCL2, OGN, EDN2, IL11, KITLG, ZP3, ERBB3, CD9, BMP6, TNXB, IL10, GPX3, ENPP1, GAL, IGFBP4, MMP8, FBLN1, ANOS1, PTPRG, TNFSF4, CFL1, IL32, IL4R, IGFBP6, TNC, AZGP1, MT3, CTSS, PTX3, S100A4, HMGB2, MST1, STOM, PON1, CALR, CFP, LOX, GRN, PCSK1, PCSK6, CTGF, IL12A, SERPINB3, CD40LG, PRDX6, SERPINB1, FGF9, SFN, S100A11, STX2, BMP8B, PRSS3, GPC1, BTC, RDX, ADM, THBS4, KRT9, FBN1, TIMP3, CHI3L1, NUDT1, GNL1, SERPINB5, SERPINF1, SNCA, RBMX, COL15A1, COL18A1, MDH1, LEP, WNT5A, PTGDS, NBL1, CXCL5, GDF5, MCAM, CTSK, NAMPT, LGALS7, XDH, CXCL12, IFNAR2, SERPINB4, CD97, COMP, PGF, VEGFC, SEPP1, SERPINB9, TNFSF10, PPT1, SMARCA4, HDGF, LUM, STC1, COPA, CTSC, CRISP3, YARS, INHBC, CDH13, WNT3, ADAMTS20, TPI1, ACTB, FGF12, LYZ, B2M, TGFB2, ACTA2, HIST1H2BC, GNB2, PPIA, RPS27A, UBA52, YWHAZ, ACTG1, ACTG2, ACTC1, EEF1A1, BLOC1S1, CCL20, CCL8, GPLD1, CXCL6, LCN2, NUCB2, DLK1, HAMP, TNFAIP6, MUC5AC, HSPG2, NDP, SORD, IL9R, IL5RA, CTBS, NUCB1, TGFBR3, TNFAIP2, CFHR1, COL14A1, FMOD, PRDX1, C1QBP, DDR1, LOXL1, MFGE8, PDE4C, PMPCA, EFEMP1, FSTL1, STX4, MERTK, PRDX4, SEMA3B, PAPPA, SELENBP1, CHIT1, ADAM9, ASAH1, PPP1R1A, ENPP2, BMPR2, CDK13, IL18, DAG1, DPYSL3, GAS6, WFDC2, SPARCL1, SEMA3A, POSTN, PCOLCE, ANGPT1, TGFBI, KISS1, ADIPOQ, IGFBP7, CARTPT, CTF1, PTGIS, HIST2H2BE, MICA, RALGAPA2, HFE, SFRP5, HDGFL1, CPZ, SFRP4, CTRB2, APOA5, POTEE, CBLN3, CES3, OLFM4, CRELD2, CCBE1, LRIG3, SOSTDC1, GLDN, IL34, QSOX2, KCP, SSH2, PODN, BMP8A, FJX1, PKHD1L1, IFNE, THNSL2, TMPRSS6, AEBP1, SERPINA12, SULF2, SULF1, SCUBE1, SLF2, FAM20C, CPNE9, CPAMD8, CMTM8, GPC2, SFRP1, LRRC17, BMPER, FAM184A, GOLM1, PCSK9, ENOX1, DMXL2, BPIFB1, ADAMTS15, SECTM1, LIPH, PIBF1, DNAJC9, SORL1, HTRA1, GGH, PCSK5, WNT2B, MYDGF, CTHRC1, SAAL1, CPB2, LOXL4, C9orf72, CMTM3, HBEGF, MUC4, SDF2, SERPINI1, S100A13, EPYC, COL12A1, OLFM1, PROL1, OMD, SEMA3C, GDF15, SOST, AIFM2, SPX, FUCA2, SPON2, APOO, GNL3, JAM3, C1QTNF1, C1QTNF3, ULBP2, TINAGL1, PDGFD, WNT5B, CXCL16, MUC13, SEMA4A, GREM2, FKRP, WFDC1, SPON1, RETN, PDGFC, CBLN4, VNN3, MTMR4, ERAP1, GPRC5B, IL37, C1RL, FLRT3, FLRT1, LMCD1, ZSWIM5, ADAMTS9, ATXN10, DKK3, CTSZ, CKLF, DKK2, GHRL, CTSF, KL, PRKAG3, DMBT1, FETUB, SERPINB13, MTUS1, APLN, NENF, ADAMTS5, COLQ, TNFSF13B, ITM2B, FRMD4B, LOXL2, HILPDA, LIPG, GPC6, CPQ, WNT6

GO:0005618

CC

cell wall

The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.

ATHL1

GO:0005622

CC

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

DENND3, ZBBX, HSD17B6, EREG, MAST4, DCLK1, SMAD9, TLR3, TGFB1I1, ACTN4, TRAF3IP2, TYROBP, TBC1D4, ADCY9, EDF1, RAMP1, RAMP3, PEX14, TADA3, BCAR3, PROSC, DIRAS3, FGF19, TBC1D8, PNP, SERPINA3, PRL, GH1, PTH, GHRH, CD74, ATP1B1, CSF1R, CTSB, ANXA5, GSTP1, CXCL1, LGALS1, TBC1D3H, CXCL8, CCL3, RRAS, GHR, ACTN1, PRKCSH, GSPT1, ACPP, STMN1, NPR3, IL1RN, EDN2, CAPN3, EFNA1, FPR1, SAT1, ERBB3, TNXB, IGFBP5, CXCR2, CD24, MT3, CALR, ADORA2B, LTK, CD40LG, AGTR1, OXTR, BTC, PTGER4, AKR1C3, GDF5, IFNAR2, SERPINB4, NPY2R, SERPINB9, CAV2, ADCY7, ADPRH, RRAD, GABARAPL2, RAB5B, NCALD, GNB1, CCL20, GPLD1, MPP1, IL5RA, ANK2, CAV1, PRKCQ, TBC1D8B, ARL16, STX4, MLLT11, SNTA1, RAB33A, TRIM14, INPP5A, UBE3C, ANGPT1, ZNHIT3, JMJD1C, SMAD1, VAMP3, LGALSL, ANO6, C11orf73, TRIM61, KRBOX4, GRTP1, MLK4, IRAK1BP1, CHIC1, TNS2, TBC1D9B, TBC1D3C, ZNF880, SPSB3, DEF8, TBC1D9, PREX2, ZNF720, GPR126, TRIM73, STK32C, TMPRSS6, TRIM42, FAM126B, ABI1, TBC1D3, PARP8, ASCC3, SFRP1, EID2, PDZD8, NCOA7, DEPTOR, NDNF, TBC1D15, RDH11, CSGALNACT1, BLNK, NUDCD2, MYLIP, RIT1, GLMN, TRIM43, DOCK10, RUNDC1, EVI5L, RASD2, RAB39B, NUDT11, ARL5B, PGLYRP2, NEDD4L, TRNT1, RASL10B, SMC6, GPER1, SMAD5, RASL11B, HEPH, TTPAL, NUDT9, FSD1L, OSBPL1A, B3GNT5, MAP1LC3B, C6orf62, MKRN2, GABARAPL1, ATG10, ALDH8A1, SLC40A1, PNPLA8, TREM1, MKKS, RTN4, ARHGEF3, TNFRSF19, PAG1, DDIT4, DDX43, WSB2, PLK2, MAT2B, GLTSCR2, DOK5, CLCF1, KL, LNPEP, CDC23, NUDT5, HPCAL4, POLI, SNX6, SSR3, TBC1D2B, RIMS2, RUVBL2, AKT3, GSTK1, SAMHD1, HBS1L, MFHAS1, RNF114, ADGRG1, ARL5A, WASF2

GO:0005623

CC

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

HMGB2, CCL8, LCN2, TEX14, NHLRC2, ATP6V0A1, CPB2, TXNDC15, NELL2, OLFM1, C1QTNF3, CAPN10, DNAJC16

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

RBM47, E2F8, MED19, MEX3A, UBE2QL1, MACROD2, ZC3H12D, PTPDC1, ZNF320, CNOT1, ZNF233, ASB14, SOBP, ZNF785, VGLL3, PHF20L1, CENPBD1, ZNF879, FAM195B, NACA, DDX39A, EYA2, APBB1, PSMD11, WRB, SUPT5H, DFFA, HIP1, CLIC1, WWP2, CDC7, ARNTL, WASL, FOXN3, IPO5, IGF2BP3, RTCA, PIK3C2A, IFRD1, MEIS1, HMGN4, NR5A2, ZNF593, VWA5A, SDCBP, DDX3X, NFIB, FBP2, ACACB, PDXK, ARID1A, BHLHE40, CDK2AP1, DYNC1I1, CCS, CHD1, CHD2, ADAM10, ENC1, ITGB1BP1, MAP2K7, PDCD5, CHEK1, ZNF213, NDC80, TNPO2, BACH1, IRF6, TAX1BP3, RGS12, AURKA, DSCR3, AZIN1, XPO1, ZNF646, PDZD2, U2SURP, ZBTB5, NACAD, SMAD7, FYB, ANGPT2, MDM4, PLSCR1, AXIN1, CTDSPL, SMAD9, UBD, OGT, HMGB3, PPM1G, HDAC3, BIRC5, TOX3, FOXP2, CD3EAP, P4HA2, NUPL2, POLR2D, SOCS1, MAFG, PER1, ZSCAN9, KDM6A, DHX15, ZBTB24, IRAK2, PSMD3, RBFOX2, SIAH2, ZNHIT1, DAPK3, ZNF264, AP5Z1, MAP3K7, EEF1E1, WDR62, PRPF3, TBX1, CBFA2T2, OIP5, RAD51C, FOXO3, SMAD6, SPRY2, SNAI2, PLRG1, PRC1, RGS10, ZNF207, LDB2, TCF21, ASNA1, ACTN4, SSNA1, NUDT21, IDH3B, ORC5, DHX16, MED14, SOX15, PARK2, SMARCA5, NUAK1, ZNF862, TRAK2, ZEB2, PIP5K1C, KDM1A, NUPR1, PPL, MGEA5, SORBS3, SYNCRIP, CREBL2, NEMF, CCNT1, CCNT2, RAD1, REV3L, JAK2, YPEL1, UGDH, LPXN, CTNND1, CDC14B, HIST1H2BK, PQBP1, DKC1, EDF1, BRD4, SHOX2, TBL1X, PPP1R11, NBN, MITF, ROCK2, MFAP3L, ZNF623, TSC22D2, CNOT3, SIN3B, DNAJB6, GADD45B, ZPR1, DUSP11, PDCD6, ZNF253, VPS4B, H2AFY, NCOR1, PEX14, TULP3, TACC1, MAF, TADA2A, SUPT3H, GPC4, SRSF10, GMNN, HSBP1, KHDRBS3, TADA3, BANF1, RPS6KA5, MED6, MYCBP2, OFD1, ADAP1, TCEA3, RAD51D, POP7, RPP40, ZNF189, PSMD10, KLF7, SASH3, SEC14L2, RNF8, DXO, RECQL4, URI1, STK17B, USP1, TPPP, MICAL2, SUPT7L, SORBS2, TOX, NFAT5, KDM4B, CLSTN1, HEXIM1, UBR5, FSBP, PRSS23, UBE4B, ZFPL1, OAZ2, ZNF205, ZRANB2, ZWINT, LUC7L3, MBD4, SBF1, GADD45G, EPM2A, CELF2, SMC2, TACC2, ZBTB7A, CD2BP2, PARN, PSMG1, NSA2, TDP2, POLR1A, CNOT4, STAMBP, NFATC1, EYA4, APBB3, PTBP3, IL33, WIZ, AIFM1, CLIC3, CBX7, NUDT3, PTTG1, BCL10, ZBED1, ACTL6A, WHSC1, LDHA, PNP, EGFR, ASS1, SERPINA3, CSTA, FOS, MYC, TGFB1, CRYAB, LMNA, APOA1, APOE, APCS, ALB, FTH1, MT2A, ESR1, ANG, RAF1, ALDOA, ANXA1, NR3C1, PRNP, MYCN, KRT1, S100B, TUBB4A, GAPDH, ERBB2, TP53, MT1E, MT1F, HSPB1, TYMS, ITGB3, S100A8, SLC25A5, MPO, EIF2S1, HMGN2, RPLP0, JUN, SSB, PRKCB, KRT8, FYN, RB1, PTMA, CDK1, S100A9, S100A6, ENO1, NPM1, TH, CENPB, KLK3, ANXA2, TUBB, ADRB2, CTSL, PFN1, HSP90AA1, HNRNPC, LYN, ZFY, NGFR, SLC3A2, MMP2, SOD3, PDHA1, CYC1, NFIC, KRT7, KRT16, RPSA, HOXC4, FGF2, HOXB5, GSTP1, LGALS1, HMGB1, ANXA4, CNP, HMOX1, PDGFRB, HNRNPA1, PARP1, POLA1, H2AFZ, HIST1H2AG, ZNF688, CHTF8, UBC, TRAPPC2, GLI3, TROVE2, MYBL1, AR, HIST1H1E, BCL2, NR2F1, TXN, MGST1, THRA, CLU, IRF1, HSPA5, EGR2, UMPS, PDHB, FGFR1, TOP1, TOP2A, G6PD, VDR, ESRRA, CDK4, PCNA, SLC25A4, TPR, SKI, XRCC5, UNG, EEF2, MT1G, KRT13, TPT1, ALAD, ADRB3, GTF2F2, HCLS1, PKM, HSP90B1, CCNB1, TYR, IDE, POU2F1, HNRNPL, ETS1, JUP, ETS2, FABP4, ACPP, FOLR1, UCHL3, FOSL1, FOSL2, AREG, NME1, ZNF44, ZNF250, HIVEP1, RPS2, TCF4, RAG1, TCF3, DSP, H2AFX, ITGB4, CREB1, PDGFRA, GCFC2, HIST1H1C, ZNF823, CPE, ZFX, ZNF12, ZNF14, ZNF17, ZNF19, ZNF20, ZNF182, ZNF22, ZNF23, ZNF24, ZKSCAN1, ZNF25, ZNF43, HMGA1, ITGA2, UBTF, JUND, TAL1, ATF7, PRKACA, CEBPB, DDX5, XBP1, LGALS3, IGFBP3, PSMC3, ERCC2, RPL7, EGR1, RPL17, RCC1, ATF1, ATF3, ATF4, ATF6, LIG1, POLR2E, ELK1, TFEB, WT1, NFKB1, ATP2B1, CCNA2, BTF3, TNFRSF1B, NR1D1, TRH, PSMB1, HIST1H2AD, BCL3, MAK, CAPN3, HNF1A, PDC, PTMS, CDK11B, GSTM3, CSRP1, FLNA, TNFAIP3, FGFR2, OSBP, RPS4Y1, UBA1, NME2, HNRNPA2B1, CALB2, NR4A1, XPA, PTGS1, SFPQ, PPIB, JAK1, SP100, AHCY, CFL1, DTYMK, NR2F2, GADD45A, POLR2A, CDK2, APC, MCM3, NFYB, AZGP1, BRD2, FAS, YY1, DNAJB1, DNAJB2, PSMA1, PSMA2, PSMA3, PSMA4, LMO2, S100P, CTNNA2, DNMT1, RPL13, S100A4, HMGB2, ZFP36, CD27, MAPK3, ARNT, DCK, CAD, CALR, PIK3R1, PSMB4, PSMB5, SSFA2, LOX, POLD1, HOXD10, SMARCA1, MAPK1, DUSP1, MZF1, RXRB, LAP3, TPP2, KDM5A, TKT, NOS3, SERPINB3, RBMS1, EEF1D, CMPK1, PEBP1, PDIA3, PPP2R1A, CDC27, CCND2, WEE1, CDC25C, POLR2B, S100A7, HOXA10, HOXA6, RRM2, HIVEP2, DNAJA1, AKT1, AKT2, HNRNPH3, HNRNPH1, YWHAB, SFN, STIP1, S100A11, OTX2, MC4R, FOXN2, CTH, DUT, HIST1H2BB, MCM4, MCM5, SHMT1, GRK5, CTNNB1, PHB, NF2, RPL22, GTF2F1, SSTR5, ADRA1A, PTGS2, ADRA1B, RORA, CBS, KRT9, IRS1, MYH9, TIMP3, FUS, DDIT3, DEK, SOX6, GLRX, ZNF93, AHR, FLT4, PSMC2, TRIM23, MAP2K2, RPL4, NUDT1, PPP1CC, GNL1, POLR2I, SREBF1, DLST, GPX4, SRP14, PPARG, ZEB1, TALDO1, SNCA, RBMX, BRCA1, COIL, CDKN1A, ANP32A, FEN1, CAPG, PBX1, PBX2, RPL13A, MLH1, STAT3, MDH2, CCNF, ID1, ETV5, BCL6, MNDA, RGS2, BUD31, UBA7, EIF1, PRKCI, ELK3, TMPO, TMPO, SKIV2L2, AKR1C3, PIK3CB, RPS27, HELZ, LRPPRC, CDKN2B, CDKN2C, NSG1, HTT, MCAM, NR4A2, SYK, RANBP1, PSMC4, GATA4, NKX2-1, TSFM, VDAC2, CBX5, MAPK8, MKI67, RECQL, ATRX, CDKN1B, NOTCH1, IER3, BRCC3, RPL5, RPS9, YAP1, IQGAP1, ID4, LGALS7, ZFP36L2, ATP5O, PREP, TFPI2, RFX2, RFX5, SOX9, NRIP1, PRRC2A, CSNK1D, MAPKAPK2, SLC11A2, NASP, CDK8, MRPL19, ALDH7A1, CDC34, CENPA, CENPF, HOXA1, CSNK1E, CEBPD, PSMB3, MCM2, ACADVL, NUMB, CLK2, PSEN1, HINT1, FHIT, RGS4, TSC2, GSK3B, CDKN1C, MRE11A, MEOX1, SERPINB9, LHX2, MXI1, ERF, ETV1, ASCL1, CDK7, KNTC1, PPT1, PAPOLA, DUSP3, NOVA1, ZNF83, ZNF84, DNA2, SMARCA2, SMARCA4, BRCA2, IRAK1, CAV2, PSMD7, STAT5B, USP11, PLXNA3, PRKX, AFF3, NR0B1, NEK2, NEK3, UBE2E1, HNRNPA3, PGD, KPNA1, POLR2J, ZNF133, ZNF136, ZNF140, ZNF138, RBM5, HRSP12, STC1, HMGA2, SLC25A1, PLK1, FOSB, CEBPG, LIMK2, PTTG1IP, POLR2K, TTC3, RCAN1, SUB1, BLM, HIRA, ATXN3, ATXN1, ATN1, TERF1, PMS1, OAZ1, YARS, PRKAA2, RAD23A, RAD23B, EMP2, GEM, NR1H2, CSE1L, VCP, MLLT10, NAP1L1, CASP9, FOXG1, SNU13, NPEPPS, HNRNPH2, SUMO3, MAZ, HDAC4, EIF6, CTBP2, SIK1, PRDM15, SOX8, MAP3K7CL, GEMIN4, KLF3, SESN2, SESN3, FOXL2, MTPN, YBEY, HIST1H2BD, ZNF445, TPI1, PTEN, PPP4C, SRP54, RAB2A, RPS3A, PSME3, RPL15, FGF12, RPL27, RPL37A, PKIA, SUMO2, UFM1, RPS7, PPP1CA, PPP1CB, CALM2, PSMC1, RPS8, RPS18, RPS13, LSM3, SNRPD1, BTG1, PSMC6, RPL7A, POLR2G, PPP2CB, RHOB, RPL23A, RPS6, HIST1H4A, HIST1H2BC, RPS25, POLR2L, RPL30, RPL10A, PPIA, RPS27A, UBA52, GRB2, TRA2B, RAC1, GNAI1, YWHAZ, UBE2B, SNRPN, DYNLL1, SKP1, EIF5A, RACK1, ACTG1, UBE2I, YBX1, EEF1A1, TUBB4B, HIST1H3D, RBM6, RPP30, GTF2I, SRPK2, SLC35A2, RAE1, IRX3, ELF3, NTHL1, CRADD, MT1H, MT1X, SIM1, SSBP2, TMF1, SARNP, SMAD3, SERF2, H3F3A, FOXK1, ZBED6, PKD1, ZXDB, XIAP, FOXO4, RBM3, ZNF200, CYCS, TFAM, SLC25A3, HDLBP, GTF2B, CDK6, CDK5, PURA, FKBP3, HNRNPU, IRF9, MDM2, E2F1, INSM1, SET, SRSF2, RUNX1, RELB, HMGCS1, DR1, SATB1, XPC, EWSR1, POU5F1, BNC1, OCRL, MEF2A, CENPE, KIF23, NRG1, ID2, APBA1, SP3, ID3, MAP2K1, NUCB1, CREB5, DST, HHEX, POU3F1, CREM, PPARD, CENPC, CEBPZ, ZNF85, ZNF117, ZNF92, RELA, NOTCH2, TLE1, TLE3, EMX2, SSBP1, REL, MXD1, EGR4, PTK2, ZNF91, ZBTB16, SRSF11, PRKCD, DUSP2, PTPN11, EXOSC9, MEF2C, TYRO3, APLP2, GABPA, RING1, RAD51, PAX8, ZNF33A, FMR1, PRDX1, EGR3, SOX4, RPL18, C1QBP, TJP1, ZFP36L1, KHDRBS1, DLX2, BAX, MCL1, POLE, PPARA, TNK2, SRSF1, FOXM1, AES, GOLGA2, PPID, SSRP1, SLFN5, ZNF844, ZNF616, NSUN2, RBBP4, NCBP1, EP300, AHNAK, ZNF763, ZNF816, SREBF2, ARHGEF5, FOXO1, TBL3, PNRC1, TFCP2, AKAP13, CDC20, TCF15, IFRD2, ILF2, ILF3, FOXC1, DLG1, TAF10, RALGDS, PTP4A2, BNIP3, HSPB3, CSTF3, TIAM1, MLLT11, PRDM2, STK4, CHAF1A, CHAF1B, KLF10, MTAP, NR1H3, CALCOCO2, EIF2B5, TARDBP, PRDX4, MAP2K5, MAPK7, CBX3, PSMD2, DUSP8, SRSF5, MAD2L1, TRIM28, G3BP1, CLN3, SKP2, MTA1, ITGB3BP, PPIL2, PPP2R5C, MAB21L1, ZNF211, UBE2V1, ORC1, IKZF1, XRCC4, PPIG, TCOF1, NFATC2, SMAD4, BIRC3, PICALM, MAMLD1, TUBB3, C1orf61, HDAC1, CAMK2D, NAE1, TDG, DGKZ, TRA2A, PWP1, MTMR2, TP53BP2, FHL1, TUBA3C, RUNX3, NACA, NCOA4, PMAIP1, BLMH, EXOSC2, TUBB2A, KLF9, C1D, CUX1, RUNX2, NFYC, CIRBP, CAMK1, COTL1, HNRNPD, TOB2, VEZF1, DGCR6, BOP1, EIF3A, TFDP1, NPAT, FAM50A, HES1, SLBP, NFE2L1, NEDD9, FAT1, MCM6, MXD4, ZNF345, ZNF268, ZNF273, ESPL1, MDC1, KANK1, MELK, SMC1A, RRP1B, DIP2A, GINS1, LPIN1, PPP2R5D, ZNF846, KIF22, MEF2D, CHD4, POU6F1, ARID5B, MTF1, DRAP1, NFATC4, NR1D2, PSME4, CUL7, SHPRH, ARHGAP19, NCAPH, KIAA0101, EMC2, WTAP, MORF4L2, SEPT2, SART3, NCAPD2, SUZ12, EXOSC7, HERC3, KARS, RRS1, POLD3, KIF14, BRD3, ACOX1, PRKD1, TCEAL1, PPP2R5A, PTGES3, STK38, NONO, PPP2R4, RNPS1, RBBP5, ERBB4, ZMYND11, ANKRD1, RPS6KA2, UBE3C, DHCR24, DLGAP5, RPS6KA1, RBMS2, PPP1R7, NR0B2, RGN, TAF5, TEAD2, TAF1A, NCOA2, TRADD, TSN, TRIP11, TRIP13, JMJD1C, TRIP6, TWIST1, TSC22D1, ELAVL1, SMAD2, SMAD1, UBE2V2, STK11, CCDC85B, NEDD8, ADIRF, USF2, EZH2, ZFHX3, ZIC1, ZNF141, ZNF77, ZYX, ZNF124, HSPB2, SEPT7, PDCD2, PKN1, PKN2, CRY1, CSRP2, SNAPC1, HLF, MAPK14, SNRNP35, NREP, PTGIS, NFIL3, HIF1A, IFI16, CDKN3, ZSCAN26, DECR1, HIST2H2BE, UGP2, DGUOK, TXNRD1, TATDN3, CPEB4, SWI5, PDS5A, ZNF423, ZNF630, LRRFIP1, TRMT5, NDUFAF6, PCGF3, ZNF791, CHD9, TKFC, ZSCAN23, GON4L, TBRG1, RABL6, ZNF568, ZNF404, ZFP69, LARP7, FILIP1L, ARID4B, MORN2, FAM98B, PDCD4, NCBP3, C11orf73, PLEKHO1, CDCA8, TAF1B, INO80D, ZNF385B, ESCO2, DCAF6, ODF2, NOM1, CMPK2, ZNF789, HERC4, ZMAT1, ZNF766, FAM76B, ZNF667, ZNF506, HABP4, SPECC1, SAMD4B, DNTTIP2, RABGAP1L, ZBTB41, HIVEP3, ARMC4, LRIF1, ZNF684, ZNF648, ZNF618, ERCC6L2, ACBD5, DCAF8, DEPDC1, RNASEH2B, BCL2L15, RSPH4A, THEMIS2, HDGFL1, STPG1, ZNF658, MEX3C, HECTD2, ATF7IP2, RIF1, STRIP1, PDE4DIP, IRAK1BP1, FAM208B, RSBN1, MBNL2, LRRC16A, LARP1B, ARL6IP4, KAZN, SEL1L3, ZNF776, INTS3, ZNF57, ZNF518A, ZNF787, PLAG1, IQSEC1, SUMO4, SFRP4, HIST2H2AA3, XAF1, OTUD7B, RALGAPA1, THOC7, DESI1, JADE1, PPP4R3A, SPOPL, ADNP2, NIPBL, RGS7BP, TENM4, ZNF280D, FAM53A, TIGD7, DPY19L2, JMJD6, PTRF, ZNF529, TMEM53, PNCK, C16orf46, ZNF585A, NFRKB, ALKBH5, ZNF449, RSBN1L, RFWD3, KLHDC10, FBXO38, BRAT1, ZC3H14, ATAD2, SLC30A9, WDR74, BRWD3, SMARCD3, ANKRD11, AFTPH, CRTC3, PARM1, ZNF562, ATF7IP, RANBP10, NSMF, KDM7A, DTHD1, BNC2, RNF111, NFXL1, ZNF600, RNF165, ZNF621, TSHZ1, PHLPP2, NEK10, USP31, USP45, KCTD1, CENPU, TUBA1A, H2AFV, RPS27L, NOL8, ZNF534, SUPT6H, DDX46, ASRGL1, DHX30, ZNF765, ZNF771, MCM10, MAEA, ZNF627, ZNF367, SETX, ZNF550, MIER3, PIWIL4, DENND4A, NUFIP2, DHX29, COMMD6, FAM220A, DCXR, AKNA, ARHGAP22, WAPL, IRF2BP2, CPEB2, BCDIN3D, NET1, FGD2, HUWE1, ZNF467, CENPV, ZSCAN2, PCGF5, ZBTB33, PEG10, PRUNE, PABPN1, MTDH, MAGI2, CASZ1, ALYREF, CAND1, TSPYL5, SGMS1, JAZF1, ZSCAN30, METTL16, SPATA24, LONP2, OSTM1, NLRC5, CHD1L, GPBP1, TRIM69, CARM1, C19orf68, MEX3D, DGKH, CEP57, RNF130, ZNF677, KIF18B, ZNF573, ZNF280B, TDRP, PPARGC1B, GATAD2A, CAMK1D, MINA, RBM45, SIAH1, AEBP1, FOXP4, NOSTRIN, ZC3H7A, BBS7, WWC1, SLF2, TP53INP2, SIRT2, KLHL7, DDIAS, ZC3H3, SMC5, CMIP, YAF2, EFCAB13, SRRM1, SUPV3L1, ZNF440, C1orf174, TRIM22, THNSL1, CMTR2, HACE1, MICU2, ZNF101, XRN1, MAML2, ZNF654, ABI1, ASPM, ZFP82, CCAR2, ZNF567, REXO1, CRIPAK, MT1M, ASCC3, METTL4, PHTF2, LCORL, PNKD, ZNF808, ZNF276, TMEM57, RPP25L, COMMD1, MYCT1, ZNF655, ZNF283, ZNF513, ZNF615, ABTB2, ZNF709, ZNF557, JMY, ZNF565, EIF1AD, ZNF610, ZNF579, ZBTB38, ZNF511, SPC24, ATAD1, INO80E, SERBP1, HJURP, NFATC2IP, ZNF485, RNF169, MSANTD4, TDRD9, RCBTB1, ZNF248, PHC3, RGS22, CPEB3, GLIS3, DUSP18, ZNF548, ZNF555, APPL2, KMT2C, FBXO22, ZMIZ2, ZNF397, FLCN, NUP37, BHLHE22, NUDT10, DBF4B, CMAS, FBXO18, CASC5, ZFP28, NCOA7, CTCFL, KIF18A, RP9, GADD45GIP1, WDR48, GABPB2, MPLKIP, UHMK1, NEIL3, FAM76A, OSR1, ZSCAN18, SETD6, ZNF502, ZNF564, MDM1, ZNF596, NT5C, PIFO, FBXO25, ZNF507, URGCP, NEK9, ZNF675, SLC2A14, DDX54, SSH3, UTP15, GEMIN5, ZNF721, UBASH3B, ZNF526, ZNF384, GSG2, ABHD5, PHF10, PPP1R13L, HDAC7, CEMIP, PTPMT1, GATAD1, NAT14, UBLCP1, ZFPM2, GLMP, PHIP, RASSF5, PRPF31, PALLD, ZNF606, PSPC1, SYNE2, PIBF1, DNAJC9, PPM1E, ARNTL2, KAT6B, JDP2, CSRNP3, AHCTF1, CHCHD10, RSPH1, AQP3, TRIB2, H1FX, TOPBP1, BAP1, DCUN1D4, NR4A3, NDRG1, APPBP2, DYRK2, GTF3A, ANP32B, RAD54L, ESR2, TNR, HDAC2, PROX1, CREBBP, KAT6A, N4BP2L2, TAF15, GGH, KAT2B, DDX17, APBB2, ERCC4, UFD1L, GATA6, SLC5A5, FGF13, FGF14, SNAPC3, EMG1, LPP, MED12, HIST1H2AC, HIST1H2BH, PTP4A1, TCEAL3, FBXO32, RPL36AL, L3MBTL2, UBE2E3, TEKT1, ZNF566, TP53INP1, RERG, FUBP1, NABP1, ACD, PBXIP1, EME1, ISG20, RAD51AP1, UBE2W, EXOSC8, CREB3L1, CHCHD1, ZNF669, UPRT, ZNF689, OPTN, R3HDM4, TMCO6, OTUB2, NUDT16, MBD6, LGALS12, SPDL1, TCEAL4, FAM120B, CYFIP2, ZNF503, PELI1, ZBED6CL, CDCA5, CPNE2, OTUB1, DPH3, CFAP36, NUDT11, RMND5B, ZNF274, AURKB, DCUN1D1, CDCA7L, MASTL, ZNF486, ZNF764, PRR11, SENP5, ZNF419, MED30, NAF1, HES6, ZNF625, AJUBA, GMCL1, ZNF845, ABHD14B, NSL1, PAWR, RSRC1, ITCH, HIC2, EAF1, MAML3, ZNF333, ZNF462, CHAMP1, L3MBTL3, LCOR, ZFP91, PDLIM2, RITA1, ZBTB45, ZNF521, PBK, FAM71F1, SCYL1, ZNF512B, EHMT2, PRMT6, IFT74, C9orf72, RNPC3, PRIMPOL, CARD19, ZSCAN31, PACRG, PRICKLE1, YTHDC1, ZNF75A, ZNF578, ZNF641, FOPNL, ZNF285, ZFP3, ASB16, NAP1L5, NECAB3, ZNF317, UHRF2, NEDD4L, QKI, FAM193B, NEK1, PUS7, SMG1, KIF20B, DLC1, PPP1R10, RAB3IP, ACRC, PURB, PHF12, SPAG5, ZNF300, PASK, CIC, CITED4, MED15, ERGIC2, NUDCD1, USP28, TRIB3, TRIB1, TP53RK, RANBP9, CSRNP1, CCNL2, SRPK1, SMC6, ZNF347, STRBP, ZNF607, ZNF587, ATOH8, ZNF382, RSF1, SPEN, SETDB2, UHRF1, FAM129B, TCF12, MYCBP, NAP1L3, CDC5L, PFDN5, GPER1, PLIN2, MPHOSPH8, TSC22D3, MNT, S100A13, SCAF11, KLF6, PHB2, COPS8, PRPF18, RAD9A, CHP1, KIF2C, MEIS3, PITX2, DOK1, SMAD5, BARD1, HNRNPAB, NAP1L4, CDC6, NPAS2, MDFI, ACO2, CIB1, EBNA1BP2, ARID3A, PRMT1, DUSP9, PKP2, CITED1, CITED2, VRK1, GDF15, NCAPG, HOPX, MAPKAP1, NABP2, TREX2, ELAC2, MACROD1, TCF25, MYBBP1A, SLF1, ZNF559, BUD13, LARP6, UQCC2, PELO, RHNO1, ZNF2, TACO1, FAM64A, MARVELD1, INPP5K, WAC, DIDO1, PAGR1, IER2, ANP32E, ZNF692, NDUFAF3, MKNK1, TUBB6, POLR3C, HNRNPUL1, HTATIP2, DDX23, FAM195A, ZNF426, DUSP26, ADI1, RNF126, MECR, SNRNP25, KATNB1, TUBB2B, DUSP23, GNL3, TIPIN, KIFC1, KATNAL1, HIRIP3, ACAT2, REPIN1, RBM4, SSBP4, FUNDC2, SF3B5, CDCA7, PAPOLG, MND1, CDK19, SSBP3, RBM24, SORBS1, SALL3, NAA15, CDCA4, PINK1, NUSAP1, TEX15, OSBPL1A, FANCD2, BEX2, SCAPER, HDAC8, RTFDC1, DUSP16, PARD6B, NFKBIZ, BACH2, WHSC1L1, NUF2, PUS3, UACA, DPH1, WDR11, TBL1XR1, PRKD2, FOXP3, UBXN6, NMES1, TRIM6, INO80B, FTO, ZNF518B, ZNF407, STRADB, POLR2J2, ACTR6, PITHD1, POLR1E, SLIRP, NIF3L1, PEG3, CTDSP1, ZNF350, UBA5, COMMD4, USP44, RNF38, RACGAP1, SIK2, WWP1, ZNF700, C11orf54, RBM38, DNTTIP1, CSRNP2, NUCKS1, ASCC2, UPF3A, CDT1, EHD4, SH3BGRL3, TRIOBP, EPC1, TSPYL2, BLZF1, PDCL3, TNKS2, IKZF4, DHX36, HIPK2, FOXP1, TXNIP, CENPH, DSN1, CHMP4B, DEF6, SENP3, RGCC, ZNF335, DUSP21, C11orf1, IKZF5, FAM96A, OBFC1, SOX17, ARMC7, YTHDC2, ESRP2, EGLN3, ZNF552, METTL17, SUDS3, TLE6, PHAX, METTL8, RMND5A, CSRP2BP, ZNF430, ZNF395, ECT2, HN1L, MRPL44, AKIRIN1, LIN28A, SAP30L, EBF2, SMURF2, UPF2, GRPEL1, CLK4, BCL2L12, PLEKHA2, SP110, RRAGC, FANCE, PATZ1, BEX1, MKNK2, SPC25, ZNF287, SLC25A19, GPBP1L1, ZBTB20, NEK6, HES4, ZNF532, METTL14, ZNF160, MAGEE1, RAVER2, AGO4, CHD8, CSNK1G1, TCF7L1, POLD4, ZNF334, SRA1, SEPSECS, RANGRF, RETN, HMG20A, MYOZ1, MID1IP1, PARD6A, MYNN, EXOSC4, UBE2T, NGRN, NOP10, BRD7, ACOT13, PNRC2, MED4, MRPL40, PLCB1, HEYL, TCF7L2, HINT3, RRAGD, PFDN4, KMT5A, EXOSC3, PRDM10, PRDM6, ZNF331, ZNF71, ZNF302, PDLIM7, POLE4, ASH1L, MBNL1, SLC2A4RG, PDGFC, EIF4ENIF1, TSHZ2, SH2B1, POLE3, ZNF277, LATS2, UBQLN4, DUSP22, INIP, HELLS, GLRX2, RASSF1, RAD18, BRWD1, SAMSN1, DIAPH3, BMP2K, PDS5B, SMC4, ZFP64, RNF146, MDN1, MBNL3, DDX28, UFSP2, TDP1, POT1, DCAF13, MED17, GNL3L, ARMC1, SDAD1, TMEM38B, THAP1, RLIM, ZNF358, RBM22, RBFOX1, RNF216, SLTM, AURKAIP1, HCFC1R1, UCKL1, GEMIN8, TRNAU1AP, LYAR, ZDHHC7, ING3, ZNF586, GAR1, AATF, SPHK1, DACT1, BCLAF1, ZAK, DONSON, MIS18A, ZNF226, CDK12, RRN3, RBAK, PRR13, FAM120A, EHF, GPRC5B, IL37, GRHL1, DTL, ZNF224, MAT2B, EHD3, DNAJC27, LMCD1, CWC15, THYN1, CRIPT, CCDC59, ZKSCAN7, AKAP7, SH3BP4, ZBTB4, ZNF492, MBD5, USP36, PAK7, BCCIP, CHD7, ZNFX1, RCOR3, MYEF2, KANSL3, HECW2, STARD9, RERE, THEG, PSMC3IP, NFKBIL1, DNMT3B, SAE1, NLK, HECA, PPARGC1A, UXT, ASH2L, HDAC6, SPAST, EIF3K, RNF14, POLK, NXF1, SLC25A10, LRWD1, ZRANB1, TES, KDM5B, PARP2, LIMD1, ZC3H7B, TCF20, APOBEC3B, MLX, MLH3, TRPS1, DCDC2, IP6K2, DDX20, NUFIP1, USP25, SAP30BP, DACH1, ZNF639, ZNF230, TEKT2, MUTYH, KLF15, CNOT7, PLXNA1, TSPYL4, MCM8, MOSPD1, ZFP69B, ERRFI1, ZNF112, PURG, ANAPC5, ANAPC4, ZNF222, ZNF580, NOCT, CCNL1, FEM1B, HN1, MRTO4, TNIK, TLK1, NUDT5, FBXO5, HDAC9, AMFR, AGO2, ELF5, ZHX1, BAG5, ZNF236, TCFL5, TAOK2, MYT1L, MTUS1, MKL2, ZBTB21, CNOT6, PPM1H, CIZ1, TPX2, NAP1L2, MAFF, TP53TG3, PYCARD, PADI4, MYO6, PLAGL1, KMT2B, NFU1, PRPF19, PHTF1, SYNPO2, SUFU, BOK, NENF, NOL7, SCML1, POLI, CDC14A, SNX6, ANGEL1, FAF1, PPIE, DIMT1, TIMELESS, NOVA2, WDR3, NSFL1C, TRIM33, TRIM35, SMG5, TRAK1, FOXJ3, AGTPBP1, DICER1, PA2G4, EXO1, CDK11A, SMC3, MAPK8IP1, HDAC5, SCML2, NIP7, RUVBL2, CDYL, TCF19, POMP, HPSE, RNF6, RUVBL1, RASD1, VDAC3, INVS, ASF1A, PKIG, SSX2IP, BTBD3, MYRF, R3HDM2, KDM2A, FAN1, PTPN22, DDX52, CRYL1, POLDIP2, KLHDC2, THRAP3, MED16, KLF13, SUGT1, DERA, SBDS, REXO2, TPRKB, FAM96B, HDGFRP3, RTCB, ZNF337, TSC22D4, NOC2L, SAMHD1, C2CD2, PKP3, KNSTRN, L3MBTL1, MTF2, JRKL, TRRAP, NFE2L3, ZNF451, USP15, LOXL2, LSM5, RNF114, CSDC2, HES2, ASB3, NUB1, YTHDF2, PAXBP1, SUPT16H, PCDHA2, UTP18, HEY1, UCHL5, ORC6, MAFB, RBM8A, ZNF706, KLF2, HCFC2, FHOD1, IRAK3, NCOR2, RAD54B, GPC6, SPIN1, EID1, MAD1L1, STK24, COMMD10, CHCHD2, CABIN1, IGF2BP2, CSNK1G3, SESN1, NCOA3, DUSP10, CAMTA1

GO:0005635

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nuclear envelope

The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

NEMP2, HAX1, CLIC1, BIN1, TOR1A, MGST3, CLGN, XPO1, NPC1, PGRMC2, NUPL2, CHMP2A, BNIP3L, NUP155, CTDNEP1, LMNA, CYBB, S100A6, PARP1, POLA1, ALOX5, TPR, RAC2, ATF6, LMNB1, RRM1, MAPK3, CLIP1, SREBF1, NUP62, TMPO, TMPO, PTGER3, RANBP1, CBX5, RANGAP1, CENPF, PCYT1A, RANBP2, EMD, ANXA11, IST1, CSE1L, SEC13, NUP107, UBE2I, RAE1, NUCB2, DST, TYRO3, BAX, NUP160, RAB40B, LRMP, BNIP3, AKAP6, CBX3, MTA1, KCNJ11, LPIN1, KPNB1, EBP, NSMF, NUP93, CNEP1R1, ABCF1, MNS1, NUP43, NUP37, NUP35, NUP210, TMEM170A, SYNE2, NUP205, SLC22A18, SEH1L, GMCL1, IPO9, GPER1, SIGMAR1, MGST2, NDC1, HTATIP2, NUP58, NUP85, NDEL1, TNKS2, CHMP4B, SPAG4, RTN4, PARP11, AGPAT3, SUN2, FAF1, PLA2G4C, RTCB

GO:0005637

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nuclear inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.

TMEM120B, NEMP2, ERN1, LMNB1, IFI27, TMPO, TMPO, LRPPRC, MATR3, PSEN2, EMD, TRA2B, SMAD3, LMNB2, CBX3, ITPR1, SMAD1, DPY19L2, DPY19L3, DPY19L4, SIGMAR1, TMEM120A, ATP11B, LEMD3

GO:0005638

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lamin filament

Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.

LMNA, LMNB1, LMNB2

GO:0005639

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integral component of nuclear inner membrane

The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

P2RX4, TMEM43, SUN2, LEMD3

GO:0005640

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nuclear outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.

SNCA, LRPPRC, PSEN1, EMD, NUTF2, GUCY2D, DMPK, ITPR3, SYNE2, SIGMAR1, DHCR7

GO:0005641

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nuclear envelope lumen

The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.

PTGES, APP, TUBB, ALOX5, IGF2R, SORL1, CACYBP

GO:0005642

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annulate lamellae

Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.

XPO1, NUP62, EIF5A

GO:0005643

CC

nuclear pore

Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.

MYO1C, IPO5, KPNA3, KPNA4, KPNA5, NUPL2, TNKS, TPR, NUP62, RANGAP1, NUP153, RANBP2, KPNA2, KPNA1, AGFG1, NUP107, EIF5A, RAE1, NUP160, MAD2L1, KPNB1, NUP93, NUP210, IPO4, AHCTF1, NUP205, NUP88, PIK3R4, NDC1, NUP58, XPO4, EIF5A2, ENY2, PARP11, NXF1, NXT1, NUP50, NPIPA1, MAD1L1

GO:0005652

CC

nuclear lamina

The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.

CASK, NUP35

GO:0005654

CC

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

PTPDC1, STRA13, DDX39A, ACOT7, MYO1C, SNAP23, EYA2, AIP, APBB1, PSMD11, PSMD12, SUPT5H, DFFA, CDC7, ARNTL, IPO5, SAP18, RTCA, GOLIM4, ELL2, NR5A2, KPNA3, VWA5A, NOP56, KPNA4, UBE2C, PDXK, ARID1A, COPE, CTDSP2, UTY, AP3D1, CHD2, ENC1, CHEK1, TFEC, AURKA, PPP1R12A, HNRNPDL, XPO1, BTAF1, U2SURP, ANKRD28, SMAD7, SCAMP1, SCAMP2, KPNA5, MDM4, POLR1C, SMAD9, FANCG, OGT, SIVA1, POLR3G, PPM1G, SOX12, HDAC3, BIRC5, CD3EAP, NUPL2, POLR2D, MAFG, KDM6A, ADAM12, PSMD3, RBFOX2, SIAH2, AP5Z1, PAX4, HOXA2, HOXA3, HNRNPR, PRPF3, PPIH, KLF4, OIP5, RAD51C, MED7, FOXO3, SPRY1, PLRG1, PRC1, BUB1, BUB3, ENSA, NUDT21, ORC5, RAD21, DHX16, PPP1R12B, MED14, SMARCA5, NUAK1, OPA1, KDM1A, HBP1, SYNCRIP, CCNT1, CCNT2, RAD1, REV3L, JAK2, UGDH, CDC14B, HIST1H2BK, PQBP1, DKC1, BRD4, TBL1X, NBN, MITF, FAM20B, ZC3H11A, RAB11FIP3, SIN3B, DNAJB6, NDUFS2, ZPR1, ZNF217, NCOR1, PRPF40A, POLQ, PSIP1, SUPT3H, SRSF10, GMNN, HSBP1, ECI2, KHDRBS3, TADA3, BANF1, SKAP2, PRKRA, CRCP, RPS6KA5, MED6, USP2, TRMU, UTP20, WDHD1, RAD51D, RNASEH2A, POP7, RPP40, PSMD10, STAM2, TNFSF13, ATP5H, CLPX, RNF8, USP1, TOX4, UBXN7, NFAT5, KDM4B, CEP152, HEXIM1, CCNB2, UBR5, FSBP, SCAF4, NDUFB6, NDUFB4, ZRANB2, LUC7L3, KIF20A, KIF4A, MBD4, SMC2, GDF11, CD2BP2, PSMG1, ETHE1, POLR1A, YEATS4, STAMBP, NFATC1, POP4, LSM8, ZMYM6, CBX7, MBD3, TOMM40, ACTL6A, CCNE2, WHSC1, DHFR, FOS, MYC, CRYAB, LMNA, ESR1, ANXA1, NR3C1, TP53, TYMS, GNAI2, ISG15, JUN, PRKCB, KRT8, UROD, RB1, PGR, PTMA, CDK1, GPI, NPM1, APRT, HSP90AA1, HNRNPC, ERCC1, NGFR, HSP90AB1, RPS17, RPSA, SNRPA, SNRPC, HMGB1, RBP1, CNP, DLD, HNRNPA1, SNRPA1, PARP1, POLA1, UCHL1, UBC, HSPA1A, HSPA1B, GLI2, GLI3, MYBL2, AR, NR2F1, TXN, THRA, IRF1, PDHB, TOP1, TOP2A, VDR, ESRRA, CDK4, PCNA, TPR, PTHLH, SKI, SKIL, XRCC5, UNG, RNH1, GTF2F2, HSD17B1, MIF, FDPS, CCNB1, SNRPB, IDE, POU2F1, HNRNPL, ETS1, ETS2, AKR1B1, FOSL2, HPGD, RPS2, RAG1, TCF3, NQO2, H2AFX, CREB1, GCFC2, ZNF12, ZNF22, HMGA1, PRKCA, JUNB, UBTF, ATF7, PRKACA, CEBPB, PTPN2, DDX5, XBP1, PSMC3, ERCC2, EGR1, SON, RCC1, ATF1, ATF3, ATF4, ATF6, LIG1, POLR2E, ELK1, NFKB1, CCNA2, NR1D1, MSH3, PSMB1, LMNB1, BCL3, FGFR2, SDHB, OSBP, RPS4Y1, SCP2, HNRNPA2B1, UQCRC2, NR4A1, XPA, SFPQ, SP100, RRM1, GADD45A, POLR2A, CDK2, APC, PTAFR, MCM3, NFYB, DNAJB1, PSMA1, PSMA2, PSMA3, PSMA4, DNMT1, CHML, HMGB2, PTBP1, MAPK3, ARNT, CAD, PSMB8, PSMB9, PSMB4, PSMB5, POLD1, MAPK1, RXRB, RBL1, LAP3, MPG, KDM5A, TKT, BLVRB, CDC27, CCND2, CCND3, WEE1, CDC25A, CDC25B, CDC25C, SRI, ALDH1B1, POLR2B, RRM2, TIA1, HIVEP2, AKT1, AKT2, HNRNPH3, HNRNPH1, GTF2H1, DUT, HIST1H2BB, MCM4, MCM5, MCM7, HSPA1L, CTNNB1, PHB, RPA3, RFC4, RFC2, GTF2F1, HRH1, RORA, FUS, DDIT3, DEK, SOX6, AHR, PSMC2, POLR2I, SREBF1, PPARG, ZEB1, RBMX, BRCA1, COIL, CDKN1A, ANP32A, FEN1, CAPG, PSMB10, PBX1, MLH1, STAT3, MDH2, RFC5, RFC3, ID1, ETV5, BCL6, UBA7, ELK3, STAT5A, SKIV2L2, RPS27, NCAPD3, LRPPRC, CDKN2B, HTT, MATR3, MSH2, NR4A2, NAMPT, PSMC4, GATA4, NKX2-1, CBX5, MAPK8, MAPK9, RECQL, CDKN1B, NOTCH1, BRCC3, RPS9, RPS5, RPS10, YAP1, SOX9, NRIP1, CSNK1D, MAPKAPK2, NASP, CDK8, CDC34, CENPA, CENPF, PRIM1, PRIM2, CSNK1E, PSMB3, MCM2, RBM25, CLK2, NUP153, RGS3, MRE11A, HNMT, ERF, CDK7, CCT8, ANXA11, PAPOLA, DAP3, DUSP3, DNA2, SMARCA2, SMARCA4, BRCA2, PSMD7, STAT5B, AFF3, NR0B1, HDGF, CCNG1, UBE2E1, HNRNPA3, HNRNPM, KPNA2, KPNA1, POLR2J, MAP2K6, STAT2, GTF2A1, GTF2A2, MSH6, RBM5, HMGA2, PLK1, CEBPG, POLR2K, SMTN, BLM, RARS, HIRA, ATXN3, ATXN1, ATN1, TERF1, PRKAG1, PRKAA2, RAD23B, NR1H2, CSE1L, VCP, MLLT10, CASP6, SEC13, SNU13, HNRNPH2, SUMO3, EIF3B, NDUFV3, ARPP19, POLE2, HDAC4, EIF6, PEX3, GEMIN4, NUP107, YBEY, TIRAP, HIST1H2BD, PTEN, PPP4C, ACTB, RPS20, CKS1B, UBE2D3, RPS3A, PSME3, STXBP1, SUMO2, DCAF7, NUTF2, RPS7, PPP1CA, PPP1CB, CALM2, PSMC1, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, SNRPF, LSM3, LSM6, SNRPD1, SNRPD2, SNRPD3, PSMC6, POLR2G, RPS6, HIST1H4A, HIST1H2BC, RPS25, RPS26, POLR2L, RBX1, RPS27A, UBA52, GRB2, TRA2B, YWHAZ, UBE2B, SKP1, RPS21, UBE2I, YBX1, HIST1H3D, CXADR, RPP30, GTF2I, PIP4K2B, SRPK2, OLR1, CCNA1, PRKDC, NTHL1, ADARB1, SARNP, CBX1, SMAD3, H3F3A, XIAP, FOXO4, RBM3, GTF2B, CDK6, CDK5, HSF1, HNRNPU, IRF9, MDM2, E2F1, INSM1, SET, SRSF2, RUNX1, RELB, FABP5, HMGCS1, SATB1, XPC, POU5F1, MEF2A, DHODH, KIF23, ALDH6A1, ID2, SP3, ID3, FKBP4, PPARD, CENPC, RELA, NOTCH2, TLE1, TLE3, REL, SRSF11, PRKCD, EXOSC9, MEF2C, GABPA, RING1, RAD51, PAX8, FMR1, SOX4, KHDRBS1, MCL1, POLE, PPARA, SRSF1, FOXM1, PPP3CA, PPID, SSRP1, NSUN2, RBBP4, NCBP1, EP300, SMAGP, FAAP100, CPSF1, TMEM94, SREBF2, ARHGEF5, FOXO1, TBL3, CDC20, SF3A3, ILF2, ILF3, FOXC1, TAF10, BNIP3, CSTF3, STRN3, COASY, ZBTB17, CHAF1B, NR1H3, TARDBP, MAPK7, PAK2, CBLB, PSMD2, GPS2, SRSF9, SRSF5, SRSF6, TRIM28, NMI, SKP2, MTA1, ITGB3BP, PPIL2, PPP2R5C, ORC1, ILK, XRCC4, PPIG, GOLGA4, FKBP5, NFATC2, SMAD4, BIRC3, SQSTM1, PRPF4B, EIF4EBP1, HDAC1, CAMK2D, TDG, DGKZ, CUL2, CUL3, CUL4A, CUL4B, TP53BP2, EXOSC2, KLF9, GTF2H2, C1D, CUX1, RUNX2, NFYC, CDK13, CIRBP, HNRNPD, DAG1, VEZF1, BOP1, MORC3, SPIDR, GIT2, POLA2, TFDP1, SIM2, ZMYM3, NPAT, E2F2, TRIM25, FAM50A, HES1, SLBP, RBM39, MCM6, ITPR3, MDC1, SMC1A, GINS1, LPIN1, PPP2R5D, CASP8, MEF2D, CHD4, ARID5B, MTF1, ZNF638, KPNB1, NR1D2, CUL7, NAA25, KIAA0101, WTAP, MORF4L2, SART3, NCAPD2, SUZ12, EXOSC7, POLD3, ACOX1, TCEAL1, PTGES3, NONO, PPP2R4, RNPS1, RBBP5, ERBB4, ZMYND11, ANKRD1, RPS6KA2, PCBP1, TCEB1, TCEB2, PUM3, RPS6KA1, NR0B2, RGN, TAF5, TAF11, TEAD4, TEAD2, TAF1C, TAF1A, NCOA2, TRIP10, JMJD1C, ELAVL1, TAB1, NCOA1, SMAD2, SMAD1, UBE2V2, STK11, ADIRF, USF2, EZH2, ZFHX3, ZIC1, ADRM1, UAP1, PKN1, PKN2, TAF12, SNAPC1, MAPK14, SNRNP35, HIF1A, IFI16, ZSCAN26, DUSP5, DECR1, KYNU, HIST2H2BE, DUSP6, DUSP7, HADH, PFKFB3, FAM110C, PDS5A, ERCC6L, TSR1, QRICH1, CHD9, TIMM50, GLYR1, ZBED5, LARP7, ARID4B, FLYWCH1, LIN52, FAM98B, PDCD4, C11orf73, IFI44L, CDCA8, SMUG1, TAF1B, SGOL2, ESCO2, ZNF326, CMPK2, CENPW, SGOL1, BCORL1, HABP4, EXOSC6, RBM48, ZC3H13, ARMC4, UBR4, PHF19, ACBD5, CPSF3L, DEPDC1, RSPH4A, RIF1, FAM208B, ICE2, SEL1L3, MSL1, INTS3, CDCA2, THOC7, JADE1, NIPBL, PWWP2B, JMJD6, FAAP20, PTRF, MIS18BP1, TATDN1, C16orf46, NFRKB, RFWD3, PPIP5K1, SHQ1, CCDC174, ZC3H14, LARP1, ATAD2, AGTRAP, SMARCD3, ANKRD12, ANKRD11, AFTPH, FIP1L1, CRTC3, ATF7IP, RAD9B, NSMF, CYHR1, KDM7A, RNF111, USP45, CENPU, RPS27L, ASXL2, CENPQ, MCM10, COPS6, EPM2AIP1, RAB11FIP2, CXXC5, ZNF367, PID1, SETX, HAUS6, EMSY, WAPL, SPRED1, CCDC91, RBBP6, HUWE1, CENPV, ZBTB33, SYVN1, PABPN1, PBRM1, USP48, CASZ1, ALYREF, CAND1, SPATA24, SLC26A11, CHD1L, GPBP1, RPS19BP1, CARM1, NCAPG2, CEP57, KMT5C, PPARGC1B, GATAD2A, DCP2, CREBRF, NAV2, MGA, ZBTB8OS, SUGP2, CCAR1, BAP18, KLHL7, SMC5, DHX37, YAF2, EFCAB13, SRRM1, FANCM, TRIM22, THNSL1, PM20D2, ZBED8, KMT2E, MAML2, CMTM8, CENPL, EID3, CCAR2, INTS1, APITD1, ASCC3, MPP5, FNBP4, TAB3, NKAP, COMMD1, EID2, KIAA1958, ABTB2, JMY, BANP, EIF1AD, ATG16L2, FANCB, HJURP, ZBTB34, RNF169, TNRC6A, PHC3, SETD9, ABCF1, GLIS3, DUSP18, MCPH1, VPS37A, KMT2C, ZMIZ2, BOD1L1, ARID1B, NUP37, NUP35, DBF4B, CMAS, CASC5, NEK11, CEP70, MFSD8, THOC2, WDR36, MPLKIP, SMARCC2, ZNF420, NEIL3, ZCRB1, TRPM4, HELQ, NEK7, MORC4, DCAF11, SH3RF2, UTP15, GEMIN5, SMCR8, PNISR, SETD7, FAM222B, PPIL4, GTF3C2, PPP1R13L, HDAC7, GATAD1, CHTF18, SNRNP27, TSEN15, ZFPM2, SLC44A1, PRPF31, SREK1, GEMIN6, ATRIP, PSPC1, SYNE2, BBX, KAT6B, AHCTF1, KCTD13, RFFL, TOPBP1, BAP1, NR4A3, HSPH1, NUP205, ANKS1A, DYRK2, GTF3A, RAD54L, ESR2, TNR, GTF2H4, HDAC2, CREBBP, KAT6A, SYMPK, EZH1, TAF15, KAT2B, DDX17, RAD50, ERCC4, UFD1L, GATA6, SMARCC1, KHSRP, SNAPC3, EMG1, ATP6V0A1, RBPMS, MED12, HIST1H2BH, POP5, FBXO32, L3MBTL2, ITFG2, PMEPA1, UTP4, TP53INP1, FUBP1, NABP1, CLUAP1, ACD, EME1, ISG20, RAD51AP1, EXOSC8, TADA1, SYTL4, OPTN, NUDT16, ANAPC16, SNRNP40, MBD6, ZBTB10, ELP4, DAZAP1, MVB12A, NRBF2, CDCA5, DPH3, AURKB, MASTL, LIN37, CENPN, TONSL, SENP5, CDKN2AIPNL, MED30, INTS4, THOC3, EAF1, MAML3, CHAMP1, FEM1C, EHMT2, ZFR, PRMT6, C9orf72, RNPC3, HS6ST2, NOL4L, ZNF641, SPATA13, TOX2, RPRD1A, UHRF2, NEDD4L, FAM193B, TRNT1, KIF20B, PPP1R10, PHF12, MAGI1, SPAG5, SNX18, NR1H4, MED15, USP28, TRIB3, TP53RK, CCNL2, SMC6, DCLRE1C, VWA9, SECISBP2, RSF1, RBM15, SPEN, SETDB2, FAM129B, YME1L1, CDC5L, NUP88, SCAF11, TEAD3, TIMM17A, DNAJC7, COPS8, RAD9A, PKMYT1, MGLL, SMAD5, BARD1, HNRNPAB, LITAF, CDC6, NPAS2, EPAS1, CIB1, ARID3A, PRMT1, PKP2, VRK1, MAPKAP1, NABP2, ELAC2, MYBBP1A, PYGO2, GINS4, GINS3, CENPK, RHNO1, POLR3GL, WAC, DCTN5, IER2, CENPO, MKNK1, POLR3C, HNRNPUL1, RPP25, MENT, HTATIP2, DDX23, SNRNP25, DSCC1, MLST8, PHF20, GNL3, TIPIN, RBM4, SF3B5, CDCA7, PAPOLG, SORBS1, TM2D1, CLEC7A, OSBPL1A, FANCD2, HDAC8, POLDIP3, DUSP16, NIFK, HELZ2, MRPS26, WHSC1L1, ASPSCR1, TBL1XR1, PRKD2, TRIM8, LRRCC1, XPO4, ZNF436, WDR12, SENP6, POLR1E, PEG3, CTDSP1, ZNF350, RNF38, RACGAP1, CCDC113, DDX47, DNTTIP1, BCL11A, ANAPC1, POLR3F, ASCC2, UPF3A, CDT1, EPC1, TSPYL2, BLZF1, IKZF4, HIPK2, PNN, FOXP1, KCTD10, CENPH, SENP3, SMARCAD1, PCIF1, C11orf1, SUV39H2, TAF1D, FAM96A, OBFC1, SOX17, ESRP2, EGLN3, SMYD3, WDR26, METTL17, SUDS3, PHAX, UBE2Z, NOL11, MED20, AKIRIN1, COPS7B, MEAF6, SAP30L, PLEKHA5, SMURF2, CACYBP, FANCE, RC3H2, PATZ1, MKNK2, VEZT, TAF9B, ETNK1, ZBTB20, NEK6, METTL14, CWC22, CHD8, TCF7L1, POLD4, SRA1, RANGRF, EXOSC4, UBE2T, NOP10, BRD7, MED4, TIMMDC1, AKIP1, HEYL, ANO2, TCF7L2, KMT5A, EXOSC3, ANLN, ACSS2, ASH1L, MBNL1, SLC2A4RG, INIP, GLRX2, RAD18, CENPM, BMP2K, PDS5B, SMC4, POT1, DCAF13, MED17, INTS7, FANCI, ASF1B, INTS10, RLIM, HAUS2, POLR3B, RBM22, ARGLU1, SLTM, PARPBP, PAK1IP1, AURKAIP1, GID8, HYPK, SYBU, ZDHHC7, ING3, CDKN2AIP, NSMCE4A, GAR1, DACT1, BCLAF1, MIS18A, CDK12, RRN3, GTSE1, EHF, GRHL1, DTL, LMCD1, CWC15, CCDC59, NDUFA13, H2AFY2, HMG20B, ZNRD1, FNIP2, KLHL8, CPSF2, MYEF2, KANSL3, STARD9, NFKBIL1, DNMT3B, ORC3, SAE1, NLK, PPARGC1A, ASH2L, POLK, DBF4, MORF4L1, NXF1, TJP2, DNAJB4, ADD3, EPHA6, ZRANB1, PRKAG3, KDM5B, PARP2, TCF20, TRPS1, IP6K2, DDX20, BAIAP2L1, SAP30BP, PUF60, ZNF639, MUTYH, BAZ1B, CNOT7, SERPINB13, ZMYM5, MCM8, TRMT6, TUBD1, CDC23, ANAPC5, ANAPC4, GGA1, NOCT, LSM7, FEM1B, MRTO4, TNIK, PITPNC1, NXT1, GTF3C4, FBXO5, HDAC9, AGO2, NUP50, ZHX1, INTS6, BLOC1S6, ZMIZ1, TPX2, NOB1, MAFF, PADI4, FZR1, ANAPC10, MYO6, PLAGL1, KMT2B, NFU1, PRPF19, SUFU, NENF, NDRG2, POLI, STUB1, CDC14A, PPIE, DIMT1, TIMELESS, WDR3, NSFL1C, PLA2G4C, SCAF8, TRIM33, SRRM2, PA2G4, EXO1, SMC3, HDAC5, ZNF148, RUVBL2, CDYL, AKT3, POMP, GINS2, HPSE, RNF6, POLH, PRELID1, RUVBL1, ASF1A, BTRC, KDM2A, DIS3, FAN1, HIF3A, RCL1, DDX52, POLR1D, THRAP3, MED16, POLR3K, FCF1, LSM2, RRP7A, SBDS, SF3B6, FAM96B, HDGFRP3, RTCB, NOC2L, SAMHD1, L3MBTL1, ZNF175, MTF2, TRRAP, LOXL2, WIPI2, LAS1L, LSM5, LSM4, SUPT16H, UTP18, HEY1, ORC6, RBM8A, HCFC2, NCOR2, MRPS18B, EID1, STK24, CABIN1, NCOA3, DDX49, DUSP10, IVNS1ABP

GO:0005655

CC

nucleolar ribonuclease P complex

A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.

POP7, RPP40, POP4, RPP30, POP5

GO:0005656

CC

nuclear pre-replicative complex

A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.

ORC3

GO:0005657

CC

replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

CHEK1, RAD51C, NBN, RAD51D, TP53, PCNA, H2AFX, DNMT1, BCL6, UBE2B, UHRF1, PIF1, RAD18

GO:0005658

CC

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

POLA1, MCM3, POLA2

GO:0005662

CC

DNA replication factor A complex

A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.

PLRG1, XPA, RPA3, PURA, TONSL, PURB, CDC5L, PRPF19

GO:0005663

CC

DNA replication factor C complex

A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.

PCNA, RFC4, RFC2, RFC5, RFC3

GO:0005664

CC

nuclear origin of replication recognition complex

A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.

ORC5, MCM2, ORC1, REPIN1, ORC3, LRWD1, ORC6

GO:0005665

CC

DNA-directed RNA polymerase II, core complex

RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

POLR2D, URI1, POLR2E, POLR2A, POLR2B, POLR2I, POLR2J, POLR2K, POLR2G, POLR2L, POLR2J2, PPARGC1A

GO:0005666

CC

DNA-directed RNA polymerase III complex

RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

POLR1C, POLR3G, CRCP, POLR2E, POLR2K, POLR2L, POLR3GL, POLR3C, POLR3F, POLR3B, POLR1D, POLR3K

GO:0005667

CC

transcription factor complex

A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

E2F8, PDLIM1, HAX1, ARNTL, MEIS1, SMAD7, SMAD9, MED7, SMAD6, LDB2, KDM1A, CREG1, FOS, JUN, PARP1, CDK4, SKI, SKIL, HCLS1, ETS1, TCF4, TCF3, HMGA1, JUNB, JUND, TAL1, CDK2, YY1, LMO2, RBL1, HOXA10, CTNNB1, AHR, ZEB1, PBX1, PBX2, NKX2-1, YAP1, SUB1, LMO4, PRKDC, SMAD3, MEF2A, POU3F1, CREM, RELA, REL, EP300, SMAD4, RUNX2, TFDP1, E2F2, NFATC4, ANKRD1, TEAD2, SMAD2, SMAD1, ZFHX3, HIF1A, ATF7IP, MINA, ARNTL2, NR4A3, GATA6, HES6, AJUBA, PITX2, SMAD5, NPAS2, EPAS1, NAA15, SOX17, BEX1, TCF7L1, MED17, RCOR3, LIMD1, TRPS1, DACH1, HDAC9, MAFB, IVNS1ABP

GO:0005668

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RNA polymerase transcription factor SL1 complex

A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.

TAF1B, TAF1D

GO:0005669

CC

transcription factor TFIID complex

A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

EDF1, TP53, ERCC1, TAF10, TAF5, TAF11, TAF12, ERCC4, TAF9B

GO:0005671

CC

Ada2/Gcn5/Ada3 transcription activator complex

A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues.

MAP3K7, TADA3, DR1, KAT2B, SGF29, CSRP2BP, POLE4, POLE3, YEATS2

GO:0005672

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transcription factor TFIIA complex

A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).

GTF2A1, GTF2A2, GTF2A1L

GO:0005674

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transcription factor TFIIF complex

A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation.

GTF2F2, GTF2F1

GO:0005675

CC

holo TFIIH complex

A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.

ERCC2, GTF2H1, CDK7, GTF2H2, GTF2H4

GO:0005677

CC

chromatin silencing complex

Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.

SMARCA5, SIRT2

GO:0005680

CC

anaphase-promoting complex

A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.

UBE2C, BUB1B, CDC27, CDC20, CUL7, UBE2S, CACUL1, ANAPC16, ANAPC1, CDC23, ANAPC5, ANAPC4, FZR1, ANAPC10

GO:0005681

CC

spliceosomal complex

Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

DDX39A, HNRNPR, PRPF3, PPIH, DHX16, LSM8, HNRNPC, SNRPA, HNRNPA1, SNRPA1, SNRPB, LGALS3, HNRNPA2B1, HNRNPH3, BUD31, RBM25, HNRNPM, RBM5, SNRPF, LSM6, SNRPD2, SNRPD3, SNRPN, SRSF2, SF3A3, RHEB, ZNF326, DHX32, CCAR2, SREK1, RBM17, PRPF18, WAC, CRNKL1, CWC22, CWC15, PTBP2, TTF2, SCAF8, LSM5, LSM4, IVNS1ABP

GO:0005682

CC

U5 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U5.

CD2BP2, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPN, SNRNP40, PRPF18, DDX23

GO:0005683

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U7 snRNP

A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs.

SNRPB, SNRPF, SNRPD3

GO:0005684

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U2-type spliceosomal complex

Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends.

PRPF31, SF3B6

GO:0005685

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U1 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U1.

PRPF40A, LUC7L3, SNRPA, SNRPC, SNRPB, SNRPF, SNRPD1, SNRPD2, SNRPD3, SNRPN, PRPF39, LUC7L, LUC7L2

GO:0005686

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U2 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U2.

SNRPA1, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPN, SF3B5, RBMX2, SF3B6

GO:0005687

CC

U4 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U4.

SNRPB, SNRPF, SNRPD1, SNRPD2, SNRPD3, SNRPN, PRPF31

GO:0005688

CC

U6 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U6.

LSM3, LSM6, LSM7, LSM2, LSM5, LSM4

GO:0005689

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U12-type spliceosomal complex

Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site.

DHX15, SNRPB, SNRPF, SNRPD1, SNRPD2, SNRPD3, YBX1, SNRNP35, ZCRB1, RNPC3, SNRNP25, SF3B5, LSM7, SF3B6

GO:0005690

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U4atac snRNP

A ribonucleoprotein complex that contains small nuclear RNA U4atac.

PRPF31

GO:0005691

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U6atac snRNP

A ribonucleoprotein complex that contains small nuclear RNA U6atac.

SART3

GO:0005694

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chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

GTPBP10, HMGB3, CD3EAP, RAD21, RAD1, POLQ, TADA2A, RECQL4, KIF4A, IL33, WHSC1, CENPB, BRCA1, RECQL, CENPE, FMR1, SSRP1, LRMP, PRPF4B, MDC1, SMC1A, ZMYND11, PUM3, PPP1R7, PDS5A, CDCA2, FAAP20, WAPL, RBBP6, SIRT2, TOP6BL, ZBTB38, BOD1L1, GSG2, SETD7, TOPBP1, UTP4, CDCA5, DDX27, ZFR, SETDB2, LLPH, RHNO1, NUSAP1, WHSC1L1, KMT5A, ASH1L, PDS5B, INTS7, DTL, HMG20B, ZBTB4, NSFL1C, SMC3, LOXL2, SUPT16H

GO:0005697

CC

telomerase holoenzyme complex

Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.

DKC1, HNRNPC, SNRPB, SNRPD3, HNRNPU, PTGES3, TEP1, NOP10, GNL3L, GAR1, SMG5