| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0097451 | CC | glial limiting end-foot | Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans. |
EIF2S1, ADGRG1 |
GO:0097452 | CC | GAIT complex | A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. |
SYNCRIP, GAPDH, EPRS, RPL13A |
GO:0097453 | CC | mesaxon | Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide. |
MAG |
GO:0097454 | CC | Schwann cell microvillus | Small finger-like extension of a Schwann cell that contacts the nodal membrane. |
AKR1B1, EZR |
GO:0097470 | CC | ribbon synapse | Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm. |
ATP2A2, CTBP2, STX3 |
GO:0097486 | CC | multivesicular body lumen | The volume enclosed by the outermost membrane of a multivesicular body. |
CTSH, SFTPC |
GO:0097489 | CC | multivesicular body, internal vesicle lumen | The volume enclosed by the membrane of the multivesicular body internal vesicle. |
EGFR |
GO:0097504 | CC | Gemini of coiled bodies | Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). |
ZPR1, GEMIN4, NPAT, GEMIN5, GEMIN6, GEMIN8, DDX20 |
GO:0097505 | CC | Rad6-Rad18 complex | A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity. |
RAD18 |
GO:0097512 | CC | cardiac myofibril | A cardiac myofibril is a myofibril specific to cardiac muscle cells. |
CRYAB |
GO:0097513 | CC | myosin II filament | A bipolar filament composed of myosin II molecules. |
MYH9 |
GO:0097524 | CC | sperm plasma membrane | A plasma membrane that is part of a sperm cell. |
HSP90AA1 |
GO:0097526 | CC | spliceosomal tri-snRNP complex | A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. |
SNRPD1, SNRPD3, LSM7, LSM4 |
GO:0097539 | CC | ciliary transition fiber | A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium). |
CENPF, ODF2, NIN, FBF1, CEP89, CEP83 |
GO:0097542 | CC | ciliary tip | Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. |
GLI2, GLI3, MAK, DYNLL1, DYNC2LI1, IFT81, KIFAP3, CLUAP1, WDR34, IFT43, IFT74, IFT27, IFT122, CYLD, IFT46, WDR35, SUFU, KIF3A, HSPB11 |
GO:0097543 | CC | ciliary inversin compartment | Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium. |
NPHP3, NEK8 |
GO:0097545 | CC | axonemal outer doublet | Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium. |
CCDC42B |
GO:0097546 | CC | ciliary base | Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. |
TULP3, GLI2, GLI3, PRKAR1A, PRKAR2A, PRKACA, PRKAR2B, ARMC4, NPHP3, NEK8, C8orf37, IFT122, SUFU |
GO:0097629 | CC | extrinsic component of omegasome membrane | The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
ULK1, ZFYVE1 |
GO:0097632 | CC | extrinsic component of pre-autophagosomal structure membrane | The component of the pre-autophagosomal structure membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
ULK1 |
GO:0097635 | CC | extrinsic component of autophagosome membrane | The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
ULK1 |
GO:0097649 | CC | A axonemal microtubule | A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule. |
C6orf165 |
GO:0097708 | CC | intracellular vesicle | Any vesicle that is part of the intracellular region. |
RAB29 |
GO:0098536 | CC | deuterosome | A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles. |
PLK4, CEP152 |
GO:0098547 | CC | lumenal side of Golgi membrane | The side of the Golgi membrane that faces the lumen. |
NUCB1 |
GO:0098554 | CC | cytoplasmic side of endoplasmic reticulum membrane | The side (leaflet) of the plasma membrane that faces the cytoplasm. |
DNAJA1 |
GO:0098556 | CC | cytoplasmic side of rough endoplasmic reticulum membrane | The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm. |
GNRH1 |
GO:0098559 | CC | cytoplasmic side of early endosome membrane | The side (leaflet) of the early endosome membrane that faces the cytoplasm. |
RAB5A, RAB21 |
GO:0098574 | CC | cytoplasmic side of lysosomal membrane | The side (leaflet) of the lysosomal membrane that faces the cytoplasm. |
EEF1A1, EEF1A2, LOH12CR1 |
GO:0098592 | CC | cytoplasmic side of apical plasma membrane | The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm. |
EZR, EXOC1 |
GO:0098636 | CC | protein complex involved in cell adhesion | Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. |
CD28 |
GO:0098745 | CC | Dcp1-Dcp2 complex | A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA. |
ZFP36 |
GO:0098793 | CC | presynapse | The part of a synapse that is part of the presynaptic cell. |
SNAP23, SYNJ1, PARK2, PIP5K1C, SNAP29, PSEN1, CDK5, FMR1, EEA1, PDZD11, NLGN1, SYTL5, SYTL4, SYT11, LIN7B, LIN7C, BLOC1S6, HRH3 |
GO:0098794 | CC | postsynapse | The part of a synapse that is part of the post-synaptic cell. |
AKT1, SNCA, GSK3B, MEF2C, FMR1, PPP3CA, RAB3GAP1, SLC29A1, GHRL |
GO:0098857 | CC | membrane microdomain | A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. |
LAMP2 |
GO:0099053 | CC | activating signal cointegrator 1 complex | A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3. |
ASCC3, ASCC2 |
GO:0099073 | CC | mitochondrion-derived vesicle | A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae. |
PARK2 |
GO:0099078 | CC | BORC complex | A protein complex that is invovled in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors. |
SNAPIN, BLOC1S1, LOH12CR1, BORCS7, BORCS6 |
GO:0099503 | CC | secretory vesicle | A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. |
DYNLT1 |
GO:1902554 | CC | serine/threonine protein kinase complex | A protein complex which is capable of protein serine/threonine kinase activity. |
CAB39 |
GO:1902560 | CC | GMP reductase complex | An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH(4)(+). |
GMPR |
GO:1902636 | CC | kinociliary basal body | A ciliary basal body that is part of a kinocilium. |
MKKS |
GO:1902711 | CC | GABA-A receptor complex | A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor). |
GABRA5 |
GO:1902737 | CC | dendritic filopodium | A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines. |
FMR1 |
GO:1902911 | CC | protein kinase complex | A protein complex which is capable of protein kinase activity. |
NEK10, MAP3K5 |
GO:1902937 | CC | inward rectifier potassium channel complex | A protein complex which is capable of inward rectifier potassium channel activity. |
KCNK1 |
GO:1903561 | CC | extracellular vesicle | Any vesicle that is part of the extracellular region. |
SDCBP, EDIL3, EFEMP2, APOA1, APOE, FGA, FGB, TFRC, GNAI2, ATP1B1, ITGB2, SERPINE2, COL6A2, COL6A3, F5, PKM, CBR1, OGN, CD9, PCMT1, GRIA4, ATP1A2, SLC12A2, GNB1, TUBB4B, FBLN2, MFGE8, DNAJC3, TUBB2A, PDCD6IP, SLC5A5, COL12A1, OLFML3, CTSF, MAN1B1 |
GO:1904115 | CC | axon cytoplasm | Any cytoplasm that is part of a axon. |
AP3D1, OPA1, KIF1B, KIF4A, SNAPIN, UCHL1, RANGAP1, AP3M2, AP3S2, BLOC1S1, HIF1A, BLOC1S3, MGARP, NDEL1, SPAST, RAB21, BLOC1S6, AP3M1 |
GO:1905103 | CC | integral component of lysosomal membrane | The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
ATP13A2 |
GO:1905202 | CC | methylcrotonoyl-CoA carboxylase complex | A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity. |
MCCC1, MCCC2 |
GO:1990008 | CC | neurosecretory vesicle | A large cytoplasmic membrane-bounded vesicle with an electron dense granular core, up to 150-200 nm in diameter, found in neurosecretory cells in the hypothalamus. |
GNRH1 |
GO:1990023 | CC | mitotic spindle midzone | The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner. |
EML1, CENPE, CTTN, MAP9, KIF18A, KIF20B |
GO:1990037 | CC | Lewy body core | The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments. |
ATF4 |
GO:1990047 | CC | spindle matrix | A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis. |
ZNF207 |
GO:1990071 | CC | TRAPPII protein complex | A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the pre-autophagosomal structure. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself. |
TRAPPC10 |
GO:1990075 | CC | periciliary membrane compartment | A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis. |
RP2, KIFAP3 |
GO:1990077 | CC | primosome complex | Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. |
PRIM1, PRIM2 |
GO:1990111 | CC | spermatoproteasome complex | A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity. |
PSMB8, PSMB9, PSMB10, PSME4 |
GO:1990124 | CC | messenger ribonucleoprotein complex | A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules. |
HNRNPA3, CPEB4, CPEB2, CPEB3 |
GO:1990130 | CC | Iml1 complex | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3. |
NPRL3 |
GO:1990131 | CC | Gtr1-Gtr2 GTPase complex | A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins. |
RRAGC, RRAGD |
GO:1990234 | CC | transferase complex | A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). |
UBE2I, PDSS1, PDSS2 |
GO:1990246 | CC | uniplex complex | A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE. |
MICU2 |
GO:1990298 | CC | bub1-bub3 complex | Protein complex that associates with the kinetochores. |
BUB3 |
GO:1990316 | CC | ATG1/ULK1 kinase complex | A protein complex consisting of ATG1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
ATG13, ULK1, SESN2, RB1CC1, TBC1D5 |
GO:1990332 | CC | Ire1 complex | A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript. |
ERN1 |
GO:1990356 | CC | sumoylated E2 ligase complex | A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase. |
UBE2I |
GO:1990357 | CC | terminal web | An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells. |
KRT19, PLS1, HFE |
GO:1990391 | CC | DNA repair complex | A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
KDM1A |
GO:1990393 | CC | 3M complex | A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity. |
OBSL1, CUL7, CCDC8 |
GO:1990423 | CC | RZZ complex | A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints. |
KNTC1, ZWILCH |
GO:1990429 | CC | peroxisomal importomer complex | A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners. |
PEX12 |
GO:1990452 | CC | Parkin-FBXW7-Cul1 ubiquitin ligase complex | A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein. |
PARK2 |
GO:1990454 | CC | L-type voltage-gated calcium channel complex | A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. |
CACNB3, CACNA2D1, CACNA1C |
GO:1990565 | CC | HSP90-CDC37 chaperone complex | A protein complex involved in stress-induced mitophagy (mitochondrial degradation). In mammals it consists of heat shock protein HSP90 and its co-chaperone CDC37. Experimental evidence suggests that the complex enables the autophosphorylation of ULK1. Phosphorylated ULK1 in turn phosphorylates ATG13 which is an essential step in mitophagy. HSP90-CDC37 binding prevents rapid ubiquitin-dependent proteosomal degradation of its targets. |
CDC37 |
GO:1990578 | CC | perinuclear endoplasmic reticulum membrane | The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. |
PIK3R1 |
GO:1990589 | CC | ATF4-CREB1 transcription factor complex | Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway. |
CREB1, ATF4 |
GO:1990590 | CC | ATF1-ATF4 transcription factor complex | Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway. |
ATF1, ATF4 |
GO:1990597 | CC | AIP1-IRE1 complex | A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein). |
ERN1 |
GO:1990604 | CC | IRE1-TRAF2-ASK1 complex | A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K). |
ERN1, MAP3K5 |
GO:1990617 | CC | CHOP-ATF4 complex | A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits. |
ATF4, DDIT3 |
GO:1990622 | CC | CHOP-ATF3 complex | A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits. |
ATF3, DDIT3 |
GO:1990630 | CC | IRE1-RACK1-PP2A complex | A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A. |
ERN1, RACK1 |
GO:1990666 | CC | PCSK9-LDLR complex | A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. |
LDLR, PCSK9 |
GO:1990667 | CC | PCSK9-AnxA2 complex | A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and Annexin A2 (AnxA2). |
ANXA2, PCSK9 |
GO:1990682 | CC | CSF1-CSF1R complex | A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand. |
CSF1R |
GO:1990707 | CC | nuclear subtelomeric heterochromatin | Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus. |
ATRX |
GO:1990712 | CC | HFE-transferrin receptor complex | A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription. |
TFRC, TF, BMPR1A, B2M, HFE, TFR2 |
GO:1990723 | CC | cytoplasmic periphery of the nuclear pore complex | Cytoplasm situated in close proximity to a nuclear pore complex. |
RANGAP1, RANBP2 |
GO:1990726 | CC | Lsm1-7-Pat1 complex | A conserved protein complex that plays an important role in coupling deadenylation and decapping in the 5'-to-3' mRNA decay pathway. An example is found in S. cerevisiae. |
LSM3, LSM7, LSM2, LSM5 |
GO:1990730 | CC | VCP-NSFL1C complex | A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97. |
VCP, NSFL1C |
GO:1990745 | CC | EARP complex | A quatrefoil tethering complex required for endocytic recycling. |
VPS52 |
GO:1990752 | CC | microtubule end | Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. |
CLIP1, ACTR1B, KIF18B |
GO:1990761 | CC | growth cone lamellipodium | A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments. |
APBB1, APP |
GO:1990796 | CC | photoreceptor cell terminal bouton | A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light. |
STX3 |
GO:1990812 | CC | growth cone filopodium | A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone. |
APBB1, APP, FMR1 |
GO:1990843 | CC | subsarcolemmal mitochondrion | A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers. |
PPARGC1A |
GO:1990844 | CC | interfibrillar mitochondrion | A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers. |
PPARGC1A |
GO:1990851 | CC | Wnt-Frizzled-LRP5/6 complex | A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6. |
LRP5, LRP6, FZD8 |
GO:1990879 | CC | CST complex | A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection. |
OBFC1 |