GO:0071010

CC

prespliceosome

A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex.

SNRPC, SNRPD1, SNRPD3, CRNKL1

GO:0071011

CC

precatalytic spliceosome

A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.

PLRG1, SON, SNU13, LSM3, SNRPD1, SNRPD2, SNRPD3, SNRNP35, AGGF1, SNRNP27, PRPF31, SNRNP40, SF3B5, CRNKL1, LSM2, RBMX2, SF3B6

GO:0071012

CC

catalytic step 1 spliceosome

A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs.

CRNKL1

GO:0071013

CC

catalytic step 2 spliceosome

A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.

HNRNPR, PLRG1, SYNCRIP, HNRNPC, HNRNPA1, SNRPA1, SNRPB, DDX5, HNRNPA2B1, HNRNPH1, RBMX, SKIV2L2, HNRNPA3, HNRNPM, SNRPF, LSM3, SNRPD1, SNRPD2, SNRPD3, SNRPN, HNRNPU, SRSF1, SF3A3, PRPF4B, CWC27, ALYREF, SRRM1, SNRNP40, CDC5L, DDX23, CRNKL1, PNN, DHX35, CWC22, RBM22, CWC15, LSM7, PRPF19, PPIE, SRRM2, LSM2, RBMX2, SF3B6, RBM8A

GO:0071014

CC

post-mRNA release spliceosomal complex

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5.

CRNKL1

GO:0071021

CC

U2-type post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.

PRPF18

GO:0071062

CC

alphav-beta3 integrin-vitronectin complex

A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin.

VTN, ITGB3, ITGA5

GO:0071065

CC

alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex

A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1.

VCAM1, ADAM8

GO:0071133

CC

alpha9-beta1 integrin-ADAM8 complex

A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8.

ADAM8

GO:0071141

CC

SMAD protein complex

A protein complex that consists of SMAD proteins; may be homomeric or heteromeric.

SMAD9, HMGA2, SMAD3, SMAD4, SMAD2, SMAD1, SMAD5

GO:0071144

CC

SMAD2-SMAD3 protein complex

A heteromeric SMAD protein complex that contains SMAD2 and SMAD3.

SMAD3, SMAD2

GO:0071159

CC

NF-kappaB complex

A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.

RELA

GO:0071203

CC

WASH complex

A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.

WASH1, CAPZB, CAPZA1, CCDC53

GO:0071204

CC

histone pre-mRNA 3'end processing complex

A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1.

SYNCRIP, SNRPB, YBX1, SLBP

GO:0071339

CC

MLL1 complex

A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.

RBBP5, INO80C, MGA, BAP18, PRPF31, PHF20, SENP3, CHD8, ASH2L, RUVBL2, RUVBL1, LAS1L

GO:0071437

CC

invadopodium

A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate.

WASH1, FSCN1, RUFY3

GO:0071438

CC

invadopodium membrane

The portion of the plasma membrane surrounding an invadopodium.

ITGB1, ITGA3, DPP4, PLAUR

GO:0071439

CC

clathrin complex

A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface.

CLTA

GO:0071458

CC

integral component of cytoplasmic side of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane.

PKD2, SPPL3, SPPL2A, HM13

GO:0071540

CC

eukaryotic translation initiation factor 3 complex, eIF3e

An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.

EIF3A

GO:0071541

CC

eukaryotic translation initiation factor 3 complex, eIF3m

An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.

EIF3B, EIF3A

GO:0071547

CC

piP-body

A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.

PIWIL4, TDRD9

GO:0071556

CC

integral component of lumenal side of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.

HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, HLA-E, HLA-DRB4, HLA-G, HLA-DPA1, CALR, CANX, HLA-A, HLA-F, BCAP31, HLA-DRB3, PKD2, HLA-DRB5, SPPL3, SPPL2A, HM13

GO:0071561

CC

nucleus-vacuole junction

An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.

PIK3R4

GO:0071564

CC

npBAF complex

A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.

ARID1A, ACTL6A, SMARCA2, SMARCA4, SMARCD3, SMARCC2, PHF10, SMARCC1, SMARCD1

GO:0071565

CC

nBAF complex

A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

ARID1A, SMARCA2, SMARCA4, SMARCD3, ARID1B, SMARCC2, DPF3, SMARCC1, SMARCD1

GO:0071595

CC

Nem1-Spo7 phosphatase complex

A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p.

CTDNEP1, CNEP1R1

GO:0071598

CC

neuronal ribonucleoprotein granule

A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.

PQBP1, FMR1, UHMK1

GO:0071665

CC

gamma-catenin-TCF7L2 complex

A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.

JUP

GO:0071682

CC

endocytic vesicle lumen

The volume enclosed by the membrane of an endocytic vesicle.

HP, APOA1, APOE, APOB, HSP90AA1, SPARC, SAA1, HSP90B1, CALR, HBB, HBA1, HSPH1, HYOU1

GO:0071782

CC

endoplasmic reticulum tubular network

A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section.

REEP5, KPNB1, RAB3GAP1, ATL3, LNP, REEP1

GO:0071797

CC

LUBAC complex

A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex.

PARK2

GO:0071817

CC

MMXD complex

A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation.

CIAO1, SLC25A5, ERCC2, FAM96B

GO:0071819

CC

DUBm complex

A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p.

ENY2

GO:0071821

CC

FANCM-MHF complex

A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes.

STRA13, FANCM, APITD1

GO:0071942

CC

XPC complex

A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2.

RAD23B, XPC

GO:0071944

CC

cell periphery

The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.

ITGB1BP1, AXIN1, KRT18, KRT19, INHBB, NID1, EZR, FUT4, NME2, ITGA3, CTNNB1, RDX, RAC3, RHOA, ACTG2, KRT17, ARHGEF5, TUBB3, PHB2, CIB1, CORO1B

GO:0071953

CC

elastic fiber

An extracellular matrix part that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.

FBLN1

GO:0071986

CC

Ragulator complex

A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling.

LAMTOR1, SLC38A9, LAMTOR3, LAMTOR2

GO:0072357

CC

PTW/PP1 phosphatase complex

A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

PPP1R12A, TOX4, PPP1CC, PPP1CA, PPP1CB, PPP1R10

GO:0072372

CC

primary cilium

A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors.

UNC119B, PDE6D, TULP3, RP2, GLI3, CSNK1A1, DYNLL1, PKD1, PDE4C, PTCH1, SPA17, CFAP126, NPHP3, NEK8, AHI1, FLCN, DYNC2LI1, IFT81, KIFAP3, CLUAP1, WDR34, IFT43, IFT74, IFT27, IFT122, IFT46, INPP5E, WDR35, DCDC2, SUFU, KIF3A, FAM179B, HSPB11

GO:0072487

CC

MSL complex

A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.

MSL1

GO:0072517

CC

host cell viral assembly compartment

A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place.

BICD1

GO:0072534

CC

perineuronal net

A dense extracellular matrix (ECM) structure that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.

TNR

GO:0072536

CC

interleukin-23 receptor complex

A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.

IL12RB1

GO:0072546

CC

ER membrane protein complex

A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.

EMC2, EMC1, EMC3

GO:0072557

CC

IPAF inflammasome complex

A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri.

CASP1, CASP4

GO:0072558

CC

NLRP1 inflammasome complex

A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.

CASP1, PYCARD

GO:0072559

CC

NLRP3 inflammasome complex

A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.

CASP1, CASP4, PYCARD

GO:0072562

CC

blood microparticle

A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.

IGLL5, CLIC1, SDCBP, CD5L, F13A1, F2, C1R, HP, PLG, CFB, SERPINC1, SERPINA3, AGT, A2M, C3, KNG1, TGFB1, APOA1, APOE, APOA2, FGA, FGB, FGG, APCS, FN1, AMBP, ORM1, AHSG, ALB, GC, TFRC, TF, VTN, A1BG, KRT1, SERPING1, C8G, PRSS1, PFN1, CFH, C1S, C4A, C4B, HSPA1A, HSPA1B, CLU, SLC2A1, HSPA6, ORM2, STOM, PON1, HSPA1L, ACTB, YWHAZ, ACTG1, ACTG2, ACTC1, HBB, HBA1, CFHR1, FCN2, CPSF3L, APOA5, POTEE, ZBTB38

GO:0072563

CC

endothelial microparticle

A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell.

ANXA5

GO:0072589

CC

box H/ACA scaRNP complex

A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs.

DKC1, NOP10, GAR1

GO:0072669

CC

tRNA-splicing ligase complex

A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.

FAM98B, ZBTB8OS, FAM98A, RTCB

GO:0072686

CC

mitotic spindle

A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.

AURKA, TADA3, EML2, CDK1, TPR, MAK, MAPK1, CAPG, RANGAP1, GEM, CDC42, DYNLL1, KIF23, GOLGA2, MAD2L1, PKD2, ESPL1, KIF22, SIRT2, SPAG5, PKP4, RACGAP1, ECT2, YEATS2, CDC14A, KNSTRN, MAD1L1

GO:0072687

CC

meiotic spindle

A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.

AURKA, SIRT2, ASPM, RSPH1

GO:0080008

CC

Cul4-RING E3 ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.

PLRG1, DCAF7, CUL4A, DCAF6, DCAF8, DCAF11, DCAF4, FBXW5, DCAF5, DCAF13

GO:0090498

CC

extrinsic component of Golgi membrane

The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

NUCB1, HID1

GO:0090534

CC

calcium ion-transporting ATPase complex

Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in).

PLN

GO:0090537

CC

CERF complex

An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters.

SMARCA1

GO:0090543

CC

Flemming body

A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.

VPS4B, NUP62, CAPG, IST1

GO:0090544

CC

BAF-type complex

A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family.

PBRM1, BRD7

GO:0090571

CC

RNA polymerase II transcription repressor complex

A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter.

DDX20

GO:0090575

CC

RNA polymerase II transcription factor complex

A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II.

NR5A2, VDR, TCF3, HMGA1, SFPQ, ARNT, PPARG, STAT3, GATA4, ASCL1, HYAL2, NR1H3, TRIM28, NONO, HIF1A, CARM1, TCF12, HNRNPAB, HIPK2

GO:0090661

CC

box H/ACA telomerase RNP complex

A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell.

DKC1, NOP10, GAR1

GO:0097025

CC

MPP7-DLG1-LIN7 complex

A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions.

DLG1, LIN7C

GO:0097038

CC

perinuclear endoplasmic reticulum

The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.

ADAM10, TRIM13, BCAP31, OSBPL6

GO:0097057

CC

TRAF2-GSTP1 complex

A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses.

GSTP1

GO:0097058

CC

CRLF-CLCF1 complex

A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex.

CLCF1

GO:0097059

CC

CNTFR-CLCF1 complex

A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space.

CLCF1

GO:0097060

CC

synaptic membrane

A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

SYNJ1, SRPX2, CRYAB, ITGB1, CPE, ITGA3, MTMR2, NIPSNAP1, RIMS4, FLRT3

GO:0097136

CC

Bcl-2 family protein complex

A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed.

BAX, MCL1

GO:0097144

CC

BAX complex

An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators.

BAX

GO:0097149

CC

centralspindlin complex

A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).

KIF23, RACGAP1, ECT2

GO:0097165

CC

nuclear stress granule

A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.

TIA1

GO:0097169

CC

AIM2 inflammasome complex

A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA.

CASP1, CASP4, PYCARD

GO:0097181

CC

protein C inhibitor-coagulation factor V complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V.

SERPINA5

GO:0097182

CC

protein C inhibitor-coagulation factor Xa complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa.

SERPINA5

GO:0097183

CC

protein C inhibitor-coagulation factor XI complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI.

SERPINA5

GO:0097197

CC

tetraspanin-enriched microdomain

A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities.

ADAM10, TSPAN14

GO:0097208

CC

alveolar lamellar body

A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.

CTSH, LAMP1, RAB7A

GO:0097225

CC

sperm midpiece

The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.

SQSTM1, IFT81, PACRG, IFT27

GO:0097226

CC

sperm mitochondrial sheath

The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.

HSP90AA1

GO:0097228

CC

sperm principal piece

The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.

HK1, ATP2B4, SPA17, ENKUR, IFT81, IFT27

GO:0097233

CC

alveolar lamellar body membrane

The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.

LAMP3

GO:0097255

CC

R2TP complex

A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.

RPAP3, RUVBL2, RUVBL1

GO:0097342

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ripoptosome

A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.

CFLAR, FADD, RIPK1, CASP8

GO:0097361

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CIA complex

The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity.

CIAO1, FAM96B

GO:0097362

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MCM8-MCM9 complex

A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links.

MCM8

GO:0097381

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photoreceptor disc membrane

Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment.

GUCA1C, GNB1, GUCY2D, GUCA1B

GO:0097386

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glial cell projection

A prolongation or process extending from a glial cell.

FMR1, SIRT2

GO:0097413

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Lewy body

Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein.

PARK2, GPX1, PINK1

GO:0097418

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neurofibrillary tangle

Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.

MAPT, CLU, NEFH, PICALM

GO:0097422

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tubular endosome

A network of fine tubules in the vicinity of the Golgi complex and around the centriole.

VPS26A, ANKRD27, VPS35, SNX6, SNX5

GO:0097431

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mitotic spindle pole

Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

EML1, GPSM2, ASPM, NIN, KIF20B, FAM83D

GO:0097433

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dense body

An electron dense body which may contain granules.

ACTB, ACTG1, SYBU

GO:0097440

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apical dendrite

A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.

MYO1D, CLU, FLNA, NSMF, CPEB3, PPARGC1A

GO:0097443

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sorting endosome

A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles.

NRP1

GO:0097447

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dendritic tree

The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.

ELOVL5

GO:0097449

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astrocyte projection

A prolongation or process extending from the soma of an astrocyte and wrapping around neurons.

APP, EZR, PINK1

GO:0097450

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astrocyte end-foot

Terminal process of astrocyte abutting non-neuronal surfaces in the brain.

MT3