GO:0045211

CC

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

APBB1, DLGAP1, MUSK, LZTS3, GABBR2, CLSTN1, CHRM2, FBXO45, CHRNB1, BCR, DMD, CHRM3, COMT, CBLN1, F2R, CHRNA5, ADORA1, GABRA5, CHRNA7, NSG1, GRIA4, GLRB, EPHA4, PTEN, NCS1, DLG4, ARF1, CDK5, ANK2, FMR1, GRIN2A, ANK3, DLG1, PICALM, DAG1, SSPN, GRM3, NTRK2, COL13A1, NSMF, ARC, CAMK2N1, LRRTM4, HOMER1, ABI1, NLGN4X, NLGN1, MINK1, ATAD1, TRPV1, CACNG8, KCTD12, PDLIM5, SIGMAR1, CLSTN2, LIN7B, MAGEE1, GOPC, NECTIN3, GPHN, HOMER3, LIN7C, PSD3, GABBR1, IGSF9B, LZTS1

GO:0045239

CC

tricarboxylic acid cycle enzyme complex

Any of the heteromeric enzymes that act in the TCA cycle.

FH

GO:0045252

CC

oxoglutarate dehydrogenase complex

A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).

DLD, DLST, OGDH

GO:0045254

CC

pyruvate dehydrogenase complex

Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).

PDHA1, DLD, DLAT, PDHB

GO:0045273

CC

respiratory chain complex II

A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.

SDHB, SDHC

GO:0045277

CC

respiratory chain complex IV

A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).

COX7B, COX7B2

GO:0045298

CC

tubulin complex

A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.

MAPT, TPT1, BICD1

GO:0045323

CC

interleukin-1 receptor complex

A protein complex that binds interleukin-1; comprises an alpha and a beta subunit.

IRAK1, TRIP6, TOLLIP

GO:0045334

CC

clathrin-coated endocytic vesicle

A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.

SFTPC, MYO1E, LMBRD1, MYO6

GO:0045335

CC

phagocytic vesicle

A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

STX6, ABCA1, ITGAV, CD36, ITGB5, CORO1A, ANXA11, RAB7A, RAB9A, CLCN3, VAMP7, RAB11A, RAB31, RAB32, RAB11B, RAB8B, SYT11, RAB34, RAB22A, RAB23

GO:0046540

CC

U4/U6 x U5 tri-snRNP complex

A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.

PRPF3, PPIH, LSM8, SNRPB, SNU13, LSM3, LSM6, SNRPD2, SNRPN, PRPF31, ZMAT2, PRPF18, LSM2, LSM5

GO:0046581

CC

intercellular canaliculus

An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.

DPP4, TJP1, MTDH

GO:0046658

CC

anchored component of plasma membrane

The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.

MFI2, EFNA1, GAS1, HYAL2, RGMB, RTN4RL1, ULBP3, ULBP2, RHBG

GO:0046696

CC

lipopolysaccharide receptor complex

A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens.

TLR4, BCL10, CD14, HSPD1

GO:0046930

CC

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

TOMM40, BCL2, NUP62, VDAC2, BAX, VDAC3

GO:0048179

CC

activin receptor complex

A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.

ACVR1B, ACVR1

GO:0048188

CC

Set1C/COMPASS complex

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

RBBP5, ASH2L

GO:0048237

CC

rough endoplasmic reticulum lumen

The volume enclosed by the membranes of the rough endoplasmic reticulum.

VTN, EDN1, LRPAP1

GO:0048269

CC

methionine adenosyltransferase complex

A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules.

MAT2A, MAT2B

GO:0048471

CC

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

TLR4, APBB1, CLIC1, EML1, CDK2AP1, DYNC1I1, ENPP3, PTGES, ITGB1BP1, AURKA, RAB29, NPC1, AXIN1, STX7, CTIF, RAD51C, ACTN4, TRIAP1, STX6, PARK2, SPAG9, BUB1B, CCNT2, LPXN, ATP9A, LDB3, COBL, OBSL1, DNAJB6, ZPR1, CLN5, DAB1, PRKRA, USP2, STC2, PDE9A, ALDH1A2, TPPP, PLEKHG5, SEC24D, SORBS2, TRIM37, SEC31A, SNAPIN, ABCA1, SLC2A10, AIFM1, BCL10, EGFR, CST3, TGFA, TFRC, TF, MT2A, S100B, GAPDH, ERBB2, MT1E, MT1F, CYBB, APP, APOD, ITGB1, KRT18, S100A6, EIF4E, ANXA2, CTSB, HSP90AA1, LAMB1, LYN, ANXA6, INHBA, ANXA4, INHBB, CNP, HMOX1, TRAPPC2, HSPA1A, HSPA1B, SPP1, CLU, LAMP1, IGF2R, CDK4, ODC1, CCL2, MT1G, PLA2G2A, HSP90B1, SLC2A4, TYR, AKR1B1, EZR, NME1, SELE, ATP2A2, PRKCA, ITGA2, SRD5A1, PAM, TNFRSF1B, RAB3B, BCL3, FLNA, ZP3, OSBP, NME2, CA4, PPIB, BDNF, MCM3, MT3, ITGA3, S100A4, HMGB2, PLN, STOM, CALR, PTPRM, CTGF, CDC25C, PRKAR2B, DNAJA1, YWHAB, GBP2, CTNNB1, NF2, FUS, CHI3L1, MAP2K2, SERPINF1, PPARG, SNCA, CDKN1A, ANP32A, PLA2G5, PTGDS, LRPPRC, ECE1, LIMS1, CSNK1D, SLC11A2, CENPF, PPM1F, PSEN2, TSC2, GSK3B, AGTR2, CDK7, FXR1, CAV2, VAMP7, PLA2G16, ATN1, EPHA5, VCP, CDH13, TPD52, MTPN, RAC3, SNAP25, RAB4B, NCS1, RAB11A, RPS6, RAP1A, GNB2, VAMP2, RACK1, MT1H, MT1X, ARF1, ARF5, SET, APBA1, FKBP4, CAV1, PRKCD, RAD51, FMR1, GALNT2, GALNT1, TWF1, AKAP13, KCNH2, RAB40B, CDC20, STX4, HYAL2, DLG1, TAF10, AKAP6, CALCOCO2, PAK2, MAD2L1, PLD1, MYO9B, PICALM, SERINC3, HDAC1, CAMK2D, TP53BP2, PTCH1, EIF4A2, MAP7, FAT1, CUL7, KIAA0101, SEPT2, RASA2, RYR3, SEC23A, TRIP10, PKN2, CDKN3, TPD52L1, HFE, WDR44, BSPRY, TWF2, RHBDD2, OLFM4, CYHR1, AATK, CYFIP1, MTDH, MAGI2, SERINC5, MEX3D, CHERP, WWC1, CCAR1, SIRT2, RASEF, VPS52, AGGF1, MT1M, CMYA5, GALNT4, PCSK9, SERBP1, MYRIP, INADL, PUM2, ZNF675, RNF128, SELM, NANOS1, NDRG1, GOLGA1, RAB8B, MAL2, OPTN, CYFIP2, BICD1, DOCK6, DGAT2, KIF20B, GSDMA, CDC5L, GPER1, PKP4, P2RX4, S100A13, COPS8, DOK1, CIB1, HEPH, CORO1B, INPP5K, NDFIP1, MLPH, PINK1, PACSIN1, ASPSCR1, RAB34, SLIRP, TOLLIP, GBP3, EHD4, TNKS2, DEF6, SYNC, CHODL, UPF2, ZFYVE1, MAGEE1, PNPLA8, NOX4, CYLD, UBQLN4, NDFIP2, FMN2, EHD3, FLRT1, VAPA, ATXN10, PI4KB, HDAC6, SPAST, VTI1B, LNPEP, MOSPD1, NOCT, AMFR, BAG5, APLN, MYO6, NDRG2, ANGEL1, FAF1, MAPK8IP1, LAMP3, RASD1, TNFSF13B, PIKFYVE, USP20, PTPN22, ARFGEF2, MAP3K4

GO:0048476

CC

Holliday junction resolvase complex

A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage.

EME2, RAD51C, EME1

GO:0048786

CC

presynaptic active zone

A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.

SYN1, ADORA1, SV2A, ERC1, GPER1, RIMS4, NUFIP1, RIMS2

GO:0048787

CC

presynaptic active zone membrane

The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.

SYT11

GO:0048788

CC

cytoskeleton of presynaptic active zone

The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites.

PCLO

GO:0051233

CC

spindle midzone

The area in the center of the spindle where the spindle microtubules from opposite poles overlap.

AURKA, BUB1B, APP, PLK1, GEM, CDC42, UNC119, KIF14, CDCA8, CENPV, ARL8A, AURKB, KIF20B, PKP4, CDC6, RACGAP1, ARL8B

GO:0051286

CC

cell tip

The region at the end of the longest axis of a cylindrical or elongated cell.

EZR, RDX, RAB8B

GO:0055037

CC

recycling endosome

An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

WASH1, KCNK1, DYNC1I1, RAB29, STX7, SLC31A1, SLC31A2, TBC1D12, ATP9A, RAB11FIP3, FCHSD2, TNF, TFRC, TF, ITGB1, RAP2A, CFTR, TUBG1, USP6, AQP2, SLC11A2, RAB4B, RAB11A, EEA1, RABEP1, VAMP3, RAB11B, HFE, LDLRAP1, RAB11FIP1, TUBA1A, VPS52, COMMD1, SH3TC2, SORL1, SGK3, OPTN, GPER1, SYT11, ACKR4, TBC1D14, VTI1B, RABGEF1, TNIK, MYO5B, ATP11B, NISCH, MYO5A, ARFGEF2

GO:0055038

CC

recycling endosome membrane

The lipid bilayer surrounding a recycling endosome.

WASH1, SCAMP1, SCAMP2, RAB11FIP3, RAP2A, RAP2B, RAB11A, RAB11B, RAB12, SLC39A4, RAB11FIP2, RFFL, SLC9A6, NDRG1, PLEKHB2, EHD4, EHD3, ZDHHC2, LAMP5, ATP11B

GO:0060053

CC

neurofilament cytoskeleton

Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons.

NDEL1

GO:0060076

CC

excitatory synapse

A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.

SRPX2, SYT1, FGFR2, ITGA3, DLG4, NLGN4X, SYT11

GO:0060077

CC

inhibitory synapse

A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.

SYT11, IGSF9B

GO:0060091

CC

kinocilium

A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia.

DCDC2

GO:0060170

CC

ciliary membrane

The portion of the plasma membrane surrounding a cilium.

CASK, GPI, DRD2, SCNN1A, EPS15, EVC, PKD1, PKD2, PTCH1, SEPT2, TCTN3, BBS7, BBS1, TTC8, TCTN2, HHIP, BBS2

GO:0060171

CC

stereocilium membrane

The portion of the plasma membrane surrounding a stereocilium.

MYO1C, FAM65B

GO:0060201

CC

clathrin-sculpted acetylcholine transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle.

SYT1

GO:0060203

CC

clathrin-sculpted glutamate transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle.

SYT1, VAMP2

GO:0060205

CC

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

ADA

GO:0060987

CC

lipid tube

A macromolecular complex that contains a tube of lipid surrounded by a protein coat.

BIN1

GO:0061202

CC

clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle.

SYT1, VAMP2

GO:0061474

CC

phagolysosome membrane

The lipid bilayer surrounding a phagolysosome.

LAMP1

GO:0061574

CC

ASAP complex

A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.

SAP18, RNPS1

GO:0061617

CC

MICOS complex

Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60.

APOOL, APOO

GO:0061618

CC

sublamina densa

The part of the basement membrane that lies beneath the lamina densa, containing anchoring fibrils, anchoring plaques, collagen fibers, and elastic fibers.

FRAS1

GO:0061689

CC

tricellular tight junction

An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet.

LSR

GO:0061700

CC

GATOR2 complex

A multiprotein subcomplex of GATOR that regulates mTOR signaling by interacting with the Rag GTPases. In humans this complex consists of Mios, WDR24, WDR59, Seh1L, Sec13.

SEC13, SESN2, SESN3, SEH1L, SESN1

GO:0065010

CC

extracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.

ALPL

GO:0070022

CC

transforming growth factor beta receptor homodimeric complex

A homodimeric receptor complex that consists of two TGF-beta receptor monomers.

TGFBR1, TGFBR2, DAB2

GO:0070032

CC

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).

SNAP25, VAMP2

GO:0070033

CC

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).

VAMP2, CPLX2

GO:0070044

CC

synaptobrevin 2-SNAP-25-syntaxin-1a complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).

VAMP2

GO:0070062

CC

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

VPS37C, MYO1G, IGLL5, ACOT7, MYO1C, SNAP23, MASP2, RAB27B, LGALS8, PSMD11, PSMD12, AGRP, CLIC1, WWP2, WASL, PIK3C2A, PLOD2, NDUFA4, CHL1, SDCBP, DDX3X, RNASET2, KPNA4, MAN2B1, FBP2, PDXK, PLPP1, PLPP3, ISLR, ENPP3, CHD2, TOR1A, ADAM10, ITGB1BP1, PDCD5, TPP1, MGST3, IRF6, TAX1BP3, RAB29, SLC27A2, HNRNPDL, PLXNB2, PFAS, NPC1, SCAMP2, ARPC2, ARPC3, PLSCR1, CTDSPL, KMO, PMM2, STX7, CAPN5, CLDN3, FLRT2, PHGDH, PSMD3, B4GALT5, EEF1E1, COCH, MGAM, AKR7A2, B4GAT1, CHMP2A, TSPAN6, ASNA1, PI15, ACTN4, ITM2A, SYNGR2, EDIL3, AHCYL1, CD5L, GNG7, SPAG9, TBC1D4, PPL, LY75, ACSL4, SNX3, GMDS, SELENOF, PDE8A, UGDH, TPST2, CTNND1, EDF1, DNAJA2, FCGR3B, WDR1, CILP, PDCD6, ATP6V1G1, VPS4B, MPDU1, ENTPD6, H2AFY, FLNB, VPS26A, TECTA, GPC4, CLN5, BANF1, LYPLA1, CREG1, RP2, IDH1, TNFSF13, ALDH1L1, RASSF9, ARL6IP5, ATP5H, FLOT1, ATP5L, NEBL, SEC14L2, WISP2, SLC22A5, DDAH1, SLIT2, MYO1D, TMEM63A, PROSC, ERLIN2, RHOBTB3, CLSTN1, PRSS23, NDUFB4, PGLS, SMC2, LYPLA2, VNN1, SFT2D2, STAMBP, WIZ, STAU1, CLIC3, ANGPTL1, DDAH2, EFEMP2, NUDT3, NDUFB10, TOMM40, PEX11B, CYB5A, LDHA, ALDH1A1, CYB5R3, GSR, PNP, GOT2, PGK1, AK1, F2, C1R, HP, PLG, PLAU, PLAT, CFB, CA2, ASS1, SPINK1, SERPINC1, SERPINA1, SERPINA3, AGT, A2M, C3, TIMP1, CST3, CSTA, KNG1, NRAS, FSHB, LHB, IGF2, IL1B, HLA-DRA, CRYAB, APOA1, APOE, APOA2, APOC1, APOC3, FGA, FGB, FGG, PMP2, GYPA, CRP, APCS, C1QA, APOH, LRG1, FN1, RBP4, AMBP, ORM1, AHSG, TTR, ALB, GC, TFRC, TF, FTL, FTH1, ANG, SLPI, VTN, FUCA1, ALDOA, CSTB, ANXA1, APOB, PRNP, SOD2, A1BG, CD74, KRT1, VWF, SHBG, TUBB4A, GAPDH, HSPB1, GNAI2, ATP1B1, APP, APOD, ALDH2, ITGB3, ITGB2, S100A8, SERPINE1, SLC25A5, SERPINA5, SERPING1, CFI, MPO, ALPL, EIF2S1, ICAM1, RPLP1, RPLP2, RPLP0, FABP3, CLEC3B, ITGB1, PRKCB, KRT18, KRT8, INSR, PTMA, CDK1, S100A9, S100A6, EIF4E, ENO1, GPI, TPM3, ITGAV, LPL, HEXA, DBI, LDHB, GPX1, P4HB, KLK3, ACYP1, CTSD, ANXA2, C8G, TUBB, PRSS1, PSAP, CTSL, PFN1, BPGM, APRT, CTSB, HSP90AA1, HNRNPC, LAMB1, LYN, FH, THBS1, RNASE1, COL1A2, ANXA6, CD55, SLC3A2, HSP90AB1, GSTA1, SOD3, MME, MGP, CD14, COL4A2, PTPRC, MFI2, CFH, VIM, RPS17, KRT19, KRT7, GNAI3, ANXA5, KRT16, RPSA, ENO2, GSTP1, CD48, LGALS1, QDPR, FBP1, ANXA4, CNP, PDGFRB, HNRNPA1, CTSH, FGR, C1S, UCHL1, FURIN, ALDOC, C4A, C4B, H2AFZ, HIST1H2AG, CHTF8, GSTT2, UBC, SAA1, SAA2, RAP2A, RNASE2, GAA, RRAS, HIST1H1E, SPP1, PTPRF, TXN, COX5B, C7, HSPD1, CLU, HSPA5, LAMC1, SLC2A1, SLC2A3, PDHB, ITGAM, PYGB, PYGM, RALA, RALB, BCR, LAMP1, G6PD, MTHFD1, IGF2R, PRPS2, PCNA, KRT3, COL6A1, COL6A2, COL6A3, CKB, FCGR2A, ANXA3, CKMT1A, BMP3, ACTN1, ACE, LAMP2, RNH1, CFTR, NCAM1, EEF2, KRT13, C6, TPT1, ALAD, PRG2, HLA-E, LCP1, PRKAR2A, ENO3, MIF, CPM, NID1, PLA2G2A, PKM, HSP90B1, MYL6B, SLC2A4, SNRPB, MMP9, HNRNPL, DARS, JUP, FABP4, AKR1B1, PVR, RAC2, ARSA, B4GALT1, ACPP, EZR, FOLR1, UCHL3, HPGD, CD46, NME1, NQO1, GNS, ARSB, RPS2, ST6GAL1, DSP, MUC1, TIMP2, CD44, NQO2, H2AFX, ITGB4, CBR1, PECAM1, EPCAM, GNB3, CPE, PLCG2, FAH, STMN1, HSPA6, RHOQ, PRKCA, GJA1, NPR3, PRKACA, DES, DDX5, PFKL, GM2A, CR1, LGALS3, IGFBP3, TCP1, IGFBP2, RPL35A, ITGB5, ARF4, RPL7, IL1RN, PGAM1, SDC1, PAM, CDH2, TSPAN8, MYL12A, CD58, VCAM1, CD53, ORM2, AMY2B, ATP2B1, CD33, KLK2, RAB3B, RAB5A, PSMB1, HIST1H2AD, COX5A, OGN, EFNA1, COL5A1, GSTM3, ATP6V1B2, ATP6V1C1, CSRP1, FLNA, TNFAIP3, NT5E, BGN, SDHB, CD9, COMT, TGM2, PCMT1, GART, TNXB, PAICS, SCP2, UBA1, GPX3, NME2, HNRNPA2B1, UQCRC2, SLC2A5, CA4, FBLN1, PTGS1, PPIB, PTPRD, PTPRG, AHCY, CFL1, RRM1, LAMA2, IGFBP6, AZGP1, MPST, FAS, DNAJB1, PSMA1, PSMA2, PSMA3, PSMA4, S100P, COL5A3, ITGA3, ITGB8, S100A4, PTBP1, TARS, CD27, FKBP2, MST1, STOM, AK4, PON1, MAOB, MAPK3, DPP4, CAD, CALR, CANX, PSMB8, PSMB9, PSMB4, PSMB5, GSTM2, MAPK1, GRN, LAP3, TNFRSF8, IMPA1, TKT, SERPINB3, MARCKS, GNA11, PBLD, ERP29, PRDX6, BLVRB, DDT, RPL12, ECHS1, CMPK1, PEBP1, PDIA3, PPP2R1A, PPP2R1B, ADSS, TSPO, SRI, GSTT1, SERPINB1, CORO1A, S100A7, PRKAR2B, FGF9, SDC4, DNAJA1, YWHAB, SFN, S100A11, PRDX2, GK, DCTD, STX2, CTH, LSP1, DUT, ABCC1, MAN1A1, GALNS, RNASE4, SHMT1, HSPA4, PRSS3, GPC1, CTNNB1, PHB, RDX, RPL22, THBS4, KRT9, FBN1, PCK1, MYH9, ACTN2, BSG, TIMP3, MYH11, GLRX, CHI3L1, TRIM23, ATP5C1, RPL4, NUDT1, PGM1, ACVR1B, SERPINB5, SERPINF1, DLST, GPX4, SCNN1A, SRP14, HPCAL1, TAGLN2, TALDO1, RBMX, LIPA, COL15A1, COL18A1, CAPG, IL6ST, CCT6A, MDH1, MDH2, EIF2S3, AQP2, MNDA, WNT5A, PTGDS, CSK, PRKCI, ACTR1B, ECI1, AKR1C3, DPP6, LIFR, ECE1, SLC1A4, NAMPT, PPIC, VDAC2, ACADSB, CRKL, NSF, RPL5, RPL28, RPS9, RPS5, RPS10, GNPDA1, IQGAP1, CAPZB, ALDH1A3, LGALS7, ATP5O, CXCL12, SERPINB4, PRRC2A, IDH2, PITPNB, CD97, MAPKAPK2, ALDH9A1, RPL34, TGM4, FASN, CCT3, ALDH7A1, SRP9, SARS, PSMB3, COMP, TMED10, HINT1, RARRES1, FHIT, SEPP1, HNMT, GNAQ, GNG4, GDI2, GATM, SLC26A2, SERPINB9, SERPINH1, TNFSF10, BCAM, PPT1, RPL14, CCT8, ANXA11, RAB5C, RAB7A, RAB9A, RAB27A, SCNN1G, PLCD1, DUSP3, SSR4, TPMT, ALDH3A2, PSMD7, SGSH, ARSD, VAMP7, LUM, PGD, HNRNPM, RAP1GDS1, ARHGDIA, ARHGDIB, HRSP12, CAPZA1, SLC25A1, SUCLG1, COPA, CTSC, PTTG1IP, IST1, SUB1, POLG, CRISP3, RARS, HIRA, CACNA2D1, PRKAG1, ATP1B3, EPHB4, EPHB1, NAGLU, GALC, SLC12A2, CSE1L, VCP, HADHB, INHBC, CDH6, CDH11, CDH13, CDH15, SEC13, NPEPPS, SUMO3, EIF3B, BID, EIF6, WNT3, GEMIN4, MTPN, HIST1H2BD, ZNF445, ARPC4, CD81, TPI1, MYL6, ACTB, RAC3, EIF4A1, RPS20, S100A10, CDC42, DSTN, RAB2A, RAB5B, CXCR4, UBE2D3, UBE2M, ACTR3, ACTR2, RAP2B, RPS3A, RPL26, RPL15, RPL27, ATP6V0D1, RPL37A, RHOA, NCALD, HSPE1, LYZ, STXBP1, B2M, DAD1, NPC2, UFM1, AP1S1, NUTF2, RRAS2, RPS7, PPP1CA, PPP1CB, CALM2, NCS1, RPS8, RPS15A, RPS16, YWHAE, RPS14, RPS18, RPS13, RPS11, LSM6, SNRPD2, SNRPD3, PSMC6, RPL7A, RAB11A, PPP2CB, ACTA2, RHOB, RPL23A, HIST1H4A, HIST1H2BC, RAB1A, RAP1A, RPS25, RPS26, GNB1, GNB2, RPL30, RPL31, RPL10A, RPL11, PPIA, RPS27A, UBA52, GRB2, RAC1, VAMP2, GNAI1, YWHAZ, DYNLL1, SKP1, GNG5, EIF5A, RACK1, ACTG1, ACTG2, YBX1, TPM4, ACTC1, EEF1A1, TUBA1B, TUBA4A, TUBB4B, PAFAH1B2, HIST1H3D, HBB, HBA1, SIRPA, CCT2, OLR1, GSTO1, BLOC1S1, BTG2, GPLD1, LCN2, NUCB2, ABAT, RPL24, ARF1, ARF5, H3F3A, GNAS, DAB2, MUC5AC, FBLN2, HSPG2, PKD1, LRP2, PITPNA, SLC25A3, REEP5, SORD, SPTBN1, SRSF2, CTBS, FABP5, IFITM3, SLC7A5, XPC, OCRL, ALDH6A1, DSC2, MAP2K1, FKBP4, PLOD1, NUCB1, CREB5, DST, TGFBR3, PLAUR, MVK, CFHR1, GBE1, KRT17, GLO1, AKR1C1, SSBP1, YWHAH, PRKCD, COL14A1, GFPT1, EXOSC9, AOX1, APLP2, PRDX1, BAX, SRSF1, CRYZ, IL10RB, DDR1, SLC20A2, MFGE8, CD47, AHNAK, ZNF763, GALNT2, BST2, FUT2, ST3GAL1, ST3GAL4, KCNMA1, EFEMP1, FSTL1, STX4, CNTN1, PTPRJ, EPS8, DLG1, MYO1E, PTP4A2, ECH1, COASY, SPP2, MTAP, PRDX4, PSMD2, SEMA3B, DNAJC3, SELENBP1, STX3, UBE2V1, SNTB2, GOLGA4, ADAM9, FKBP5, MTM1, SQSTM1, TUBB3, ASAH1, DCTN2, PKD2, IQGAP2, SEMA5A, MTMR2, CUL3, CUL4B, ALCAM, SHROOM2, BLMH, TUBB2A, COTL1, HNRNPD, NID2, IL18, DAG1, DSG2, DYNC1H1, CTTN, FGL2, GALE, GAS6, WFDC2, SPARCL1, FAT1, NBR1, INPP5A, PLS1, GANAB, RFTN1, PTGR1, KPNB1, CLCA4, SEPT2, RAB3GAP1, EEA1, PDIA6, PAFAH1B3, PCOLCE, PTGES3, PPP2R4, QPRT, PCBP1, TCEB2, RHEB, ANGPT1, PPP1R7, FCN2, TGFBI, TRIP10, MYLK, SLC1A5, UBE2V2, STK11, STXBP2, NEDD8, ADIRF, ADIPOQ, RAB11B, SEPT7, IGFBP7, PDCD2, SLC15A2, LAMA4, MAPK14, CDC37, DPYSL2, FSCN1, DECR1, QPCT, HAGH, HIST2H2BE, LAMA3, PCK2, PTPRO, UGP2, ATP6V1F, TXNRD1, TMEM132A, SPHKAP, IAH1, HLA-DRB5, TKFC, ZSCAN23, ALDH1L2, ANO6, PABPC1L, GREB1, C11orf73, PLA1A, COBLL1, TAF1B, CYBRD1, IGSF11, MEST, MUM1L1, NHLRC3, GNAS, COLEC12, MUC21, FNBP1L, EYS, WLS, CROCC, STRIP1, CDC42BPA, LRRC16A, CD276, CPZ, STEAP4, DMKN, HIST2H2AA3, PTRHD1, LAIR1, LAMTOR1, TWF2, NAPEPLD, NIPBL, TCTN3, HIBCH, SLC39A4, OGFOD3, ATAD2, POTEE, CSPG4, SBSN, C5orf46, CES3, OLFM4, PLXDC2, PI16, KIAA1324, THSD4, GBP6, SLCO4C1, FAM65A, VPS13C, TUBA1A, H2AFV, BTN2A1, CYFIP1, COPS6, HIST3H2A, MON2, TMC6, HDDC2, C6orf120, DCXR, SDK1, HUWE1, TMED4, GALNT7, OAF, RTN4RL1, ALYREF, SERINC5, TAX1BP1, CAND1, SLC26A11, LSR, AEBP1, HID1, SLC44A2, TEX14, ZBTB8OS, FAM20C, CPNE9, PM20D2, ALDH16A1, KIAA0319L, ABI1, TMEM256, MPP5, SFRP1, GALNT4, MINK1, TAB3, ARRDC1, COMMD1, CD177, PDDC1, GOLM1, UXS1, RNF149, SERBP1, GSTCD, APPL2, ATP6V1C2, GPRC5A, CASC5, SVIP, INADL, ZNF420, TBC1D15, NT5C, SPPL2A, BPIFB1, SNX29, SCARB1, RAB2B, PDCD6IP, MITD1, N6AMT2, NUDCD2, SECTM1, BTN2A2, ITLN1, SLC44A1, PHIP, GPR98, SYNE2, AHCTF1, TTN, FAM3C, NDRG1, HSPH1, DOCK2, SORL1, ANP32B, TFG, RYR2, HTRA1, N4BP2L2, GGH, BCL2L2, KIFAP3, GLG1, SLC5A5, RAB8B, ATP6V0A1, EXT2, HIST1H2AC, HIST1H2BH, PTP4A1, HGD, MYDGF, MAL2, TMBIM1, C11orf52, TMEM106A, FAM162A, ARL8A, PTER, DOCK10, AP2M1, KCTD12, MVB12A, CYFIP2, SAT2, CPNE2, S100A16, OTUB1, PGM2, ZNF486, ABHD14B, CPB2, ITCH, LOXL4, PDLIM2, HS6ST2, CLIC6, PGLYRP2, NEDD4L, VPS35, SNX18, MYADM, SERINC2, SPEN, FAM129B, MUC4, NEU1, MPHOSPH8, P2RX4, SERPINI1, S100A13, DNAJC7, PHB2, COPS8, CHP1, COL12A1, TM9SF2, CIB1, CCT7, SH3GL2, RARRES2, OMD, SEMA3C, GDF15, AIF1L, CORO1B, CPPED1, SDF4, FAM213A, ERP44, LXN, AGMAT, PRADC1, UPK3B, H2AFJ, FUCA2, DHRS4, SPON2, TUBB6, PDCD10, DDX23, BDH2, ABHD6, MLPH, DUSP26, DUSP23, GGACT, NUDT9, ACAT2, C1QTNF3, TMEM59, OSBPL1A, CADM1, FUT8, CDHR2, PARD6B, UACA, RAB34, FAM129A, UBXN6, TINAGL1, PDGFD, CTDSP1, NAA50, IQCG, CRISPLD2, TOLLIP, RACGAP1, WWP1, RAB1B, C11orf54, NAPB, SDCBP2, CYSTM1, TRPV6, WNT5B, EHD4, SPTBN4, SH3BGRL3, ALDH8A1, SLC38A1, DHX36, PPA2, CRISPLD1, PABPC3, GHITM, BOLA2, MUC13, CHMP4B, TOR3A, TUBB1, RHOJ, GLIPR2, GSTO2, METTL7A, MOB1A, SCPEP1, CACYBP, ROBO2, TMEM8A, CD248, RETN, APMAP, CD209, ABCB6, VTA1, CD320, ACOT13, PLCB1, CRTAC1, GPRC5C, RTN4, HINT3, XPNPEP3, MAN1C1, ASH1L, MXRA5, PDGFC, DUOX2, AASDHPPT, PLSCR4, CDC42SE2, PHPT1, SERINC1, LTBP3, TM7SF3, ECHDC1, GINM1, TMEM106B, LIN7C, ARL8B, C1orf123, B3GNT2, HAO2, UGGT1, ERAP1, CISD1, CLIC5, GLTP, GPRC5B, MAT2B, ITSN2, C1RL, CRIM1, MPP6, NDUFA13, H2AFY2, SH3BP4, ARHGAP23, MBD5, ANKFY1, SUCLA2, SPRR3, CLCF1, SPAST, VPS29, EIF3K, GRHPR, CTSZ, DNAJB9, CTSF, UQCR10, DNAJB4, KL, MIOX, DMBT1, FETUB, LAMTOR3, PCYOX1, SLC7A8, BAIAP2L1, ATP6V1H, SERPINB13, PLXNA1, GNPTG, TNIK, PILRA, NUDT5, VAV3, PCOLCE2, RAB21, RAB22A, RAB23, MYO5B, FZD4, MGAT4A, EPDR1, MYO6, PPT2, SNX12, NDRG2, PCDHGC3, SLC6A14, STUB1, PROCR, MINPP1, THSD7A, RIMS2, PA2G4, RUVBL2, PIN4, PLAA, RUVBL1, ST3GAL6, VDAC3, VSIG4, ITM2B, MAN2B2, GSTK1, LAMTOR2, CRYL1, CARHSP1, THRAP3, DERA, SH3GLB1, CAB39, HBS1L, TLN1, KIF3A, MYO5A, HYOU1, SAMM50, HSPB11, ATP6V1D, GMPPB, MMP24, CDC42BPB, SNX9, LYVE1, HEBP2, PSAT1, F11R, CPQ, ADGRG1, STK24, WNT6, TEX264, NCOA3, SLC4A4, PCLO, WASF2, ENPP4, LOC440434

GO:0070083

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clathrin-sculpted monoamine transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle.

SYT1, VAMP2, SLC18A2

GO:0070110

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ciliary neurotrophic factor receptor complex

A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR.

IL6R, IL6ST

GO:0070176

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DRM complex

A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification.

LIN52

GO:0070187

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telosome

A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.

TERF1, ACD, POT1

GO:0070195

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growth hormone receptor complex

A receptor complex that consists of two identical subunits and binds growth hormone.

GHR

GO:0070274

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RES complex

A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p.

BUD13, RBMX2

GO:0070369

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beta-catenin-TCF7L2 complex

A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.

CTNNB1, TCF7L2

GO:0070382

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exocytic vesicle

A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.

IGF1, RAB27A, DPYSL3, SYTL5, SYTL4, SYTL2

GO:0070390

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transcription export complex 2

A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sus1p and Cdc31p.

ENY2

GO:0070419

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nonhomologous end joining complex

A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends.

XRCC5, PRKDC, XRCC4, DCLRE1C

GO:0070435

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Shc-EGFR complex

A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.

EGFR

GO:0070436

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Grb2-EGFR complex

A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway.

GRB2, TNK2

GO:0070449

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elongin complex

A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits.

TCEB1, TCEB2

GO:0070461

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SAGA-type complex

A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.

TADA2B, SGF29, USP22

GO:0070469

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respiratory chain

The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

UQCRHL, UQCRQ, UQCR11, CYC1, CYCS, HIGD1A

GO:0070522

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ERCC4-ERCC1 complex

A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae.

ERCC1, ERCC4

GO:0070531

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BRCA1-A complex

A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.

BRCA1, BRCC3, BARD1

GO:0070545

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PeBoW complex

A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.

BOP1, WDR12, WDR37

GO:0070552

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BRISC complex

A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains.

BRCC3, FAM175B

GO:0070554

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synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof).

CPLX2

GO:0070557

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PCNA-p21 complex

A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.

PCNA, CDKN1A

GO:0070578

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RISC-loading complex

A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.

ZFP36, AGO4, AGO2, DICER1

GO:0070603

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SWI/SNF superfamily-type complex

A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.

ATRX

GO:0070618

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Grb2-Sos complex

A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.

KHDRBS1

GO:0070652

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HAUS complex

A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex.

HAUS5, HAUS6, HAUS1, HAUS7, HAUS4, HAUS2

GO:0070685

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macropinocytic cup

A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin.

SNX5

GO:0070688

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MLL5-L complex

A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively.

OGT, PPP1CC, ACTB, PPP1CA, PPP1CB, STK38, KMT2E

GO:0070695

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FHF complex

A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex).

HOOK3, HOOK2, AKTIP

GO:0070724

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BMP receptor complex

A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits.

BMP2

GO:0070761

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pre-snoRNP complex

A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes.

NOP56, NUFIP1

GO:0070762

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nuclear pore transmembrane ring

A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.

NDC1

GO:0070765

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gamma-secretase complex

A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.

TMED10, PSEN1, APH1B, APH1A

GO:0070776

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MOZ/MORF histone acetyltransferase complex

A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.

KAT6B, KAT6A, MEAF6

GO:0070820

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tertiary granule

A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.

STX7, ADAM8, STXBP2

GO:0070821

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tertiary granule membrane

The lipid bilayer surrounding a tertiary granule.

SLC11A1

GO:0070822

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Sin3-type complex

Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.

BRMS1L, SUDS3

GO:0070826

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paraferritin complex

A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme.

SLC11A2

GO:0070847

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core mediator complex

A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

MED14, MED6, MED4

GO:0070852

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cell body fiber

A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.

ASS1, PENK, SRD5A1, SRD5A2, KCNJ11, SPTBN4

GO:0070860

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RNA polymerase I core factor complex

A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.

TAF1B

GO:0070876

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SOSS complex

A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80.

INTS3, NABP1, NABP2, INIP

GO:0070937

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CRD-mediated mRNA stability complex

A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, IGF2BP1 and at least four additional proteins: HNRNPU, SYNCRIP, YBX1, and DHX9.

SYNCRIP, YBX1, HNRNPU

GO:0070938

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contractile ring

A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles.

PRC1, DAG1, KIF20B

GO:0070971

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endoplasmic reticulum exit site

An endoplasmic reticulum part at which COPII-coated vesicles are produced.

PDCD6, SEC31A, APOB, PDCD6IP, YIPF5, TMED5

GO:0071001

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U4/U6 snRNP

A ribonucleoprotein complex that contains base-paired U4 and U6 small nuclear RNAs.

PPIH, SART3

GO:0071004

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U2-type prespliceosome

A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.

PRPF40A, LUC7L3, SNRPC, SNRPB, SNRPN, PRPF39, LUC7L, LSM7, LUC7L2

GO:0071006

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U2-type catalytic step 1 spliceosome

A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.

CWC22, RBM22

GO:0071007

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U2-type catalytic step 2 spliceosome

A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.

RBM22

GO:0071008

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U2-type post-mRNA release spliceosomal complex

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs.

DHX15, GCFC2